Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiondinucleotide insertion or deletion binding

MSH2 PCNA

3.73e-053712GO:0032139
GeneOntologyMolecularFunctionprotein kinase A regulatory subunit binding

AKAP6 PJA2 RYR2

9.37e-0525713GO:0034237
GeneOntologyMolecularFunctionDNA insertion or deletion binding

MSH2 PCNA

1.85e-046712GO:0032135
GeneOntologyMolecularFunctionMutLalpha complex binding

MSH2 PCNA

2.59e-047712GO:0032405
GeneOntologyMolecularFunctionmismatch repair complex binding

MSH2 PCNA

6.72e-0411712GO:0032404
GeneOntologyMolecularFunctionmismatched DNA binding

MSH2 PCNA

1.10e-0314712GO:0030983
GeneOntologyMolecularFunctioninositol 1,4,5 trisphosphate binding

TRPC1 ITPR2

1.10e-0314712GO:0070679
GeneOntologyMolecularFunctionprotein kinase A binding

AKAP6 PJA2 RYR2

1.16e-0358713GO:0051018
GeneOntologyMolecularFunctioncalcium channel activity

CACNA1A TRPC1 RYR2 ITPR2

1.16e-03129714GO:0005262
GeneOntologyMolecularFunctioncalcium ion binding

MMRN1 EFCAB6 SYT11 CCDC47 PLCB1 MACF1 PLCB3 RYR2 ITPR2

1.30e-03749719GO:0005509
GeneOntologyMolecularFunctioncalmodulin binding

CACNA1A PLCB1 PLCB3 RYR2 MYO5C

1.36e-03230715GO:0005516
GeneOntologyMolecularFunctionprotein kinase A catalytic subunit binding

PJA2 RYR2

1.45e-0316712GO:0034236
GeneOntologyMolecularFunctionintracellularly gated calcium channel activity

RYR2 ITPR2

1.84e-0318712GO:0015278
GeneOntologyMolecularFunctioncalcium ion transmembrane transporter activity

CACNA1A TRPC1 RYR2 ITPR2

2.06e-03151714GO:0015085
GeneOntologyMolecularFunctionubiquitin protein ligase activity

PJA2 WWP2 TRIM54 BFAR TRIM13 MEFV

2.08e-03372716GO:0061630
GeneOntologyBiologicalProcesscalcium ion transmembrane import into cytosol

AKAP6 CACNA1A TRPC1 PLCB1 PLCB3 RYR2 ITPR2

8.85e-06217707GO:0097553
GeneOntologyBiologicalProcessrelease of sequestered calcium ion into cytosol

AKAP6 TRPC1 PLCB1 PLCB3 RYR2 ITPR2

1.02e-05146706GO:0051209
GeneOntologyBiologicalProcessnegative regulation of sequestering of calcium ion

AKAP6 TRPC1 PLCB1 PLCB3 RYR2 ITPR2

1.07e-05147706GO:0051283
GeneOntologyBiologicalProcessregulation of sequestering of calcium ion

AKAP6 TRPC1 PLCB1 PLCB3 RYR2 ITPR2

1.15e-05149706GO:0051282
GeneOntologyBiologicalProcesssequestering of calcium ion

AKAP6 TRPC1 PLCB1 PLCB3 RYR2 ITPR2

1.34e-05153706GO:0051208
GeneOntologyBiologicalProcessintracellular calcium ion homeostasis

AKAP6 CACNA1A CCDC47 TRPC1 PLCB1 PLCB3 RYR2 ITPR2

2.87e-05359708GO:0006874
GeneOntologyBiologicalProcesscalcium ion homeostasis

AKAP6 CACNA1A CCDC47 TRPC1 PLCB1 PLCB3 RYR2 ITPR2

5.07e-05389708GO:0055074
GeneOntologyBiologicalProcessphosphatidylinositol catabolic process

PLCB1 PLCB3

6.78e-054702GO:0031161
GeneOntologyCellularComponentZ disc

PDLIM3 PPP1R12B TRIM54 NEXN RYR2

1.53e-04151705GO:0030018
GeneOntologyCellularComponentsarcomere

PDLIM3 PPP1R12B TRPC1 TRIM54 NEXN RYR2

1.86e-04249706GO:0030017
GeneOntologyCellularComponentI band

PDLIM3 PPP1R12B TRIM54 NEXN RYR2

2.37e-04166705GO:0031674
GeneOntologyCellularComponentmyofibril

PDLIM3 PPP1R12B TRPC1 TRIM54 NEXN RYR2

3.06e-04273706GO:0030016
GeneOntologyCellularComponentcontractile muscle fiber

PDLIM3 PPP1R12B TRPC1 TRIM54 NEXN RYR2

4.22e-04290706GO:0043292
GeneOntologyCellularComponentsarcoplasmic reticulum membrane

AKAP6 RYR2 ITPR2

4.61e-0445703GO:0033017
GeneOntologyCellularComponentjunctional sarcoplasmic reticulum membrane

AKAP6 RYR2

4.89e-0410702GO:0014701
GeneOntologyCellularComponentsupramolecular fiber

CASP14 PDLIM3 EFCAB6 PPP1R12B TRPC1 DNAH17 TRIM54 CFAP206 MACF1 NEXN MEFV RYR2

4.99e-0411797012GO:0099512
GeneOntologyCellularComponentsupramolecular polymer

CASP14 PDLIM3 EFCAB6 PPP1R12B TRPC1 DNAH17 TRIM54 CFAP206 MACF1 NEXN MEFV RYR2

5.31e-0411877012GO:0099081
GeneOntologyCellularComponentcation channel complex

AKAP6 CACNA1A KCNJ3 TRPC1 RYR2

1.15e-03235705GO:0034703
DomainPLC-beta_C

PLCB1 PLCB3

4.03e-053692IPR014815
DomainPLC-beta_CS

PLCB1 PLCB3

4.03e-053692IPR009535
DomainDUF1154

PLCB1 PLCB3

4.03e-053692PF06631
DomainPLC-beta_C

PLCB1 PLCB3

4.03e-053692PF08703
DomainPLC-beta

PLCB1 PLCB3

8.03e-054692IPR016280
DomainRIH_assoc

RYR2 ITPR2

2.00e-046692PF08454
DomainRIH_assoc-dom

RYR2 ITPR2

2.00e-046692IPR013662
DomainRIH_dom

RYR2 ITPR2

2.00e-046692IPR000699
DomainIns145_P3_rcpt

RYR2 ITPR2

2.00e-046692IPR014821
DomainRyanodine_recept-rel

RYR2 ITPR2

2.00e-046692IPR015925
Domain-

RYR2 ITPR2

2.00e-0466921.25.10.30
DomainRYDR_ITPR

RYR2 ITPR2

2.00e-046692PF01365
DomainIns145_P3_rec

RYR2 ITPR2

2.00e-046692PF08709
DomainARM-type_fold

DOCK2 INTS7 NBEAL2 VEPH1 PUM2 ARMH3 ITPR2

2.51e-04339697IPR016024
DomainZnf_C3HC4_RING-type

BMI1 PJA2 TRIM54 BFAR TRIM13

4.36e-04172695IPR018957
DomainMIR

RYR2 ITPR2

5.94e-0410692PS50919
DomainMIR

RYR2 ITPR2

5.94e-0410692PF02815
DomainMIR

RYR2 ITPR2

5.94e-0410692SM00472
DomainMIR_motif

RYR2 ITPR2

5.94e-0410692IPR016093
DomainIon_trans_dom

CACNA1A TRPC1 RYR2 ITPR2

8.39e-04114694IPR005821
DomainIon_trans

CACNA1A TRPC1 RYR2 ITPR2

8.39e-04114694PF00520
DomainPLipase_C_Pinositol-sp_Y

PLCB1 PLCB3

1.37e-0315692IPR001711
DomainEF-hand_like

PLCB1 PLCB3

1.37e-0315692PF09279
DomainPIPLC_Y_DOMAIN

PLCB1 PLCB3

1.37e-0315692PS50008
DomainPI-PLC_fam

PLCB1 PLCB3

1.37e-0315692IPR001192
DomainPLC_EF-hand-like

PLCB1 PLCB3

1.37e-0315692IPR015359
DomainPI-PLC-Y

PLCB1 PLCB3

1.37e-0315692PF00387
DomainPLCYc

PLCB1 PLCB3

1.37e-0315692SM00149
Domainzf-C3HC4

BMI1 PJA2 TRIM54 BFAR TRIM13

1.40e-03223695PF00097
DomainC2

SYT11 WWP2 PLCB1 PLCB3

1.40e-03131694PF00168
DomainC2

SYT11 WWP2 PLCB1 PLCB3

1.66e-03137694SM00239
DomainC2

SYT11 WWP2 PLCB1 PLCB3

1.89e-03142694PS50004
DomainPI-PLC-X

PLCB1 PLCB3

1.98e-0318692PF00388
DomainPLCXc

PLCB1 PLCB3

1.98e-0318692SM00148
DomainBBOX

TRIM54 TRIM13 MEFV

2.12e-0369693SM00336
Domain-

SYT11 WWP2 PLCB1 PLCB3

2.20e-031486942.60.40.150
DomainPIPLC_X_DOMAIN

PLCB1 PLCB3

2.21e-0319692PS50007
DomainPLipase_C_PInositol-sp_X_dom

PLCB1 PLCB3

2.21e-0319692IPR000909
Domain-

TRIM54 TRIM13 MEFV

2.30e-03716934.10.45.10
Domainzf-B_box

TRIM54 TRIM13 MEFV

2.40e-0372693PF00643
Domain-

EFCAB6 PLCB1 MACF1 PLCB3 RYR2

2.78e-032616951.10.238.10
DomainZnf_RING_CS

BMI1 TRIM54 BFAR TRIM13

3.11e-03163694IPR017907
DomainC2_dom

SYT11 WWP2 PLCB1 PLCB3

3.18e-03164694IPR000008
DomainZF_BBOX

TRIM54 TRIM13 MEFV

3.24e-0380693PS50119
DomainZnf_B-box

TRIM54 TRIM13 MEFV

3.35e-0381693IPR000315
Domain-

PLCB1 PLCB3

3.82e-03256923.20.20.190
DomainPLC-like_Pdiesterase_TIM-brl

PLCB1 PLCB3

3.82e-0325692IPR017946
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_SPTBN2_TO_MGLUR1_TRPC3_SIGNALING_PATHWAY

PLCB1 PLCB3 ITPR2

6.26e-0610543M47661
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_PRKCG_TO_MGLUR1_TRPC3_SIGNALING_PATHWAY

PLCB1 PLCB3 ITPR2

8.58e-0611543M49033
PathwayWP_CELLTYPE_DEPENDENT_SELECTIVITY_OF_CCK2R_SIGNALING

TRPC1 PLCB1 RYR2

1.48e-0513543M39589
PathwayKEGG_MEDICUS_REFERENCE_MGLUR1_TRPC3_SIGNALING_PATHWAY

PLCB1 PLCB3 ITPR2

1.48e-0513543M47656
PathwayKEGG_MEDICUS_REFERENCE_MACHR_CA2_APOPTOTIC_PATHWAY

PLCB1 PLCB3 ITPR2

5.78e-0520543M47688
PathwayKEGG_CALCIUM_SIGNALING_PATHWAY

CACNA1A TRPC1 PLCB1 PLCB3 RYR2 ITPR2

5.82e-05178546M2890
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_MACHR_CA2_APOPTOTIC_PATHWAY

PLCB1 PLCB3 ITPR2

6.73e-0521543M47689
PathwayWP_PKCGAMMA_CALCIUM_SIGNALING_IN_ATAXIA

CACNA1A PLCB1 PLCB3

7.77e-0522543M39795
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY

PLCB1 PLCB3 ITPR2

7.77e-0522543M47690
PathwayKEGG_MEDICUS_REFERENCE_MGLUR5_CA2_APOPTOTIC_PATHWAY

PLCB1 PLCB3 ITPR2

7.77e-0522543M47675
PathwayREACTOME_REGULATION_OF_INSULIN_SECRETION

CACNA1A PLCB1 PLCB3 ITPR2

8.54e-0561544MM15071
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_HTT_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY

PLCB1 PLCB3 ITPR2

8.91e-0523543M47676
PathwayKEGG_LONG_TERM_DEPRESSION

CACNA1A PLCB1 PLCB3 ITPR2

1.46e-0470544M8232
PathwayREACTOME_INTEGRATION_OF_ENERGY_METABOLISM

CACNA1A PLCB1 PLCB3 ITPR2

1.63e-0472544MM14631
PathwayKEGG_MEDICUS_PATHOGEN_HCMV_UL33_TO_GNAQ_PLCB_G_CALCINEURIN_SIGNALING_PATHWAY

PLCB1 PLCB3

2.14e-046542M47548
PathwayREACTOME_REGULATION_OF_INSULIN_SECRETION

CACNA1A PLCB1 PLCB3 ITPR2

2.22e-0478544M1921
PathwayWP_CALCIUM_REGULATION_IN_CARDIAC_CELLS

CACNA1A KCNJ3 PLCB3 RYR2 ITPR2

2.41e-04147545MM15854
PathwayWP_CALCIUM_REGULATION_IN_CARDIAC_CELLS

CACNA1A KCNJ3 PLCB3 RYR2 ITPR2

2.73e-04151545M39329
PathwayPID_IL8_CXCR2_PATHWAY

DOCK2 PLCB1 PLCB3

2.92e-0434543M210
PathwayKEGG_MEDICUS_REFERENCE_CASR_PTH_SIGNALING_PATHWAY

PLCB1 PLCB3

2.99e-047542M47505
PathwayREACTOME_ACETYLCHOLINE_REGULATES_INSULIN_SECRETION

PLCB1 PLCB3

3.97e-048542MM15032
PathwayREACTOME_FATTY_ACIDS_BOUND_TO_GPR40_FFAR1_REGULATE_INSULIN_SECRETION

PLCB1 PLCB3

3.97e-048542M27356
PathwayREACTOME_FATTY_ACIDS_BOUND_TO_GPR40_FFAR1_REGULATE_INSULIN_SECRETION

PLCB1 PLCB3

3.97e-048542MM15100
PathwayWP_MISMATCH_REPAIR

MSH2 PCNA

5.10e-049542MM15932
PathwayKEGG_MEDICUS_REFERENCE_TAC3_TACR3_PLC_PKC_SIGNALING_PATHWAY

PLCB1 PLCB3

6.35e-0410542M47644
PathwayREACTOME_ACETYLCHOLINE_REGULATES_INSULIN_SECRETION

PLCB1 PLCB3

6.35e-0410542M1825
PathwayREACTOME_INTEGRATION_OF_ENERGY_METABOLISM

CACNA1A PLCB1 PLCB3 ITPR2

7.67e-04108544M17034
PathwayREACTOME_FREE_FATTY_ACIDS_REGULATE_INSULIN_SECRETION

PLCB1 PLCB3

7.75e-0411542M27317
PathwayREACTOME_FREE_FATTY_ACIDS_REGULATE_INSULIN_SECRETION

PLCB1 PLCB3

7.75e-0411542MM15035
PathwayKEGG_MEDICUS_REFERENCE_KISS1_KISS1R_PLCB_PKC_SIGNALING_PATHWAY

PLCB1 PLCB3

7.75e-0411542M47637
PathwayBIOCARTA_MYOSIN_PATHWAY

PPP1R12B PLCB1

7.75e-0411542M7014
PathwayKEGG_MEDICUS_REFERENCE_CA2_CAM_VGCC_RYR_SIGNALING_PATHWAY

CACNA1A RYR2

7.75e-0411542M47958
PathwayREACTOME_INOSITOL_PHOSPHATE_METABOLISM

PLCB1 PLCB3 PPIP5K2

8.14e-0448543M26964
PathwayREACTOME_INOSITOL_PHOSPHATE_METABOLISM

PLCB1 PLCB3 PPIP5K2

8.14e-0448543MM14589
PathwayKEGG_MEDICUS_REFERENCE_GPCR_PLCB_ITPR_SIGNALING_PATHWAY

PLCB1 PLCB3 ITPR2

9.17e-0450543M47951
PathwayKEGG_MEDICUS_REFERENCE_TRH_TRHR_PLCB_PKC_SIGNALING_PATHWAY

PLCB1 PLCB3

9.27e-0412542M47649
PathwayKEGG_MEDICUS_REFERENCE_TSH_DUOX2_TG_SIGNALING_PATHWAY

PLCB1 PLCB3

9.27e-0412542M47628
PathwayKEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION

PPP1R12B PLCB1 PLCB3 ITPR2

9.71e-04115544M9387
PathwayREACTOME_G_PROTEIN_MEDIATED_EVENTS

PLCB1 PLCB3 ITPR2

1.15e-0354543M26911
PathwayREACTOME_ION_HOMEOSTASIS

TRPC1 RYR2 ITPR2

1.15e-0354543M27460
PathwayREACTOME_ION_HOMEOSTASIS

TRPC1 RYR2 ITPR2

1.15e-0354543MM15202
PathwayWP_GPR40_PATHWAY

PLCB1 PLCB3

1.46e-0315542M39526
PathwayREACTOME_MISMATCH_REPAIR

MSH2 PCNA

1.46e-0315542M27442
PathwayREACTOME_MISMATCH_REPAIR

MSH2 PCNA

1.46e-0315542MM15184
PathwayREACTOME_CA2_PATHWAY

PLCB1 PLCB3 ITPR2

1.71e-0362543M27321
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABBERANT_ATXN2_3_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY

PLCB1 PLCB3

2.12e-0318542M47659
PathwayREACTOME_BETA_CATENIN_INDEPENDENT_WNT_SIGNALING

PLCB1 PSMC2 PLCB3 ITPR2

2.34e-03146544M27288
PathwayBIOCARTA_CCR3_PATHWAY

PPP1R12B PLCB1

2.36e-0319542MM1361
PathwayKEGG_MEDICUS_REFERENCE_CXCL12_CXCR4_PKC_ERK_SIGNALING_PATHAWAY

PLCB1 PLCB3

2.36e-0319542M47596
PathwayBIOCARTA_PAR1_PATHWAY

PPP1R12B PLCB1

2.36e-0319542MM1514
PathwayBIOCARTA_PAR1_PATHWAY

PPP1R12B PLCB1

2.36e-0319542M3494
PathwayKEGG_MEDICUS_VARIANT_SCRAPIE_CONFORMATION_PRPSC_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY

RYR2 ITPR2

2.36e-0319542M47760
PathwayKEGG_MEDICUS_PATHOGEN_HCMV_US28_TO_GNAQ_PLCB_G_CALCINEURIN_SIGNALING_PATHWAY

PLCB1 PLCB3

2.36e-0319542M47543
PathwayBIOCARTA_CCR3_PATHWAY

PPP1R12B PLCB1

2.36e-0319542M9152
PathwayKEGG_LONG_TERM_POTENTIATION

PLCB1 PLCB3 ITPR2

2.43e-0370543M3115
PathwayWP_ALZHEIMERS_DISEASE

PLCB1 PLCB3 ITPR2

2.84e-0374543MM15962
PathwayKEGG_MEDICUS_REFERENCE_GNRH_GNRHR_PLCB_PKC_SIGNALING_PATHWAY

PLCB1 PLCB3

2.89e-0321542M47638
PathwayREACTOME_PRESYNAPTIC_FUNCTION_OF_KAINATE_RECEPTORS

PLCB1 PLCB3

2.89e-0321542M27409
PathwayREACTOME_PRESYNAPTIC_FUNCTION_OF_KAINATE_RECEPTORS

PLCB1 PLCB3

2.89e-0321542MM15159
PathwayKEGG_MEDICUS_REFERENCE_CXCR4_GNAQ_PLCB_G_CALCINEURIN_SIGNALING_PATHWAY

PLCB1 PLCB3

2.89e-0321542M47542
PathwayWP_NONGENOMIC_ACTIONS_OF_125_DIHYDROXYVITAMIN_D3

PLCB1 PLCB3 RXRG

2.95e-0375543M39568
PathwayKEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM

PLCB1 PLCB3 ITPR2

3.07e-0376543M9052
PathwayKEGG_MISMATCH_REPAIR

MSH2 PCNA

3.46e-0323542M13515
PathwayWP_DNA_MISMATCH_REPAIR

MSH2 PCNA

3.46e-0323542M39668
Pubmed

Defining the membrane proteome of NK cells.

DOCK2 XRN2 SERPINB9 CCDC47 NBEAL2 WWP2 ICAM2 GNL2 CD58 PSMC2 MSH2 DHX9 ITPR2

6.16e-071168711319946888
Pubmed

Apical localization of a functional TRPC3/TRPC6-Ca2+-signaling complex in polarized epithelial cells. Role in apical Ca2+ influx.

TRPC1 PLCB1 PLCB3

6.79e-07971315623527
Pubmed

Identifying biological pathways that underlie primordial short stature using network analysis.

WBP11 XRN2 CASP14 LARS1 GNL2 MACF1 MSH2 SF3B2 PCNA MYO5C DHX9 ITPR2

1.03e-061024711224711643
Pubmed

Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development.

CACNA1A TRPC1 RYR2 ITPR2

1.12e-063871430786075
Pubmed

Synergistic Signaling by Light and Acetylcholine in Mouse Iris Sphincter Muscle.

PLCB1 PLCB3 ITPR2

3.64e-061571328578927
Pubmed

Functional local crosstalk of inositol 1,4,5-trisphosphate receptor- and ryanodine receptor-dependent Ca2+ release in atrial cardiomyocytes.

RYR2 ITPR2

4.11e-06271228158491
Pubmed

Ins(1,4,5)P(3) regulates phospholipase Cbeta1 expression in cardiomyocytes.

PLCB1 ITPR2

4.11e-06271218692062
Pubmed

Activation of store-mediated calcium entry by secretion-like coupling between the inositol 1,4,5-trisphosphate receptor type II and human transient receptor potential (hTrp1) channels in human platelets.

TRPC1 ITPR2

4.11e-06271211336651
Pubmed

Overexpression of Bmi‑1 promotes epithelial‑mesenchymal transition in CD133+Hep G2 cells.

BMI1 PROM1

4.11e-06271228849237
Pubmed

Functional relevance of the de novo coupling between hTRPC1 and type II IP3 receptor in store-operated Ca2+ entry in human platelets.

TRPC1 ITPR2

4.11e-06271218249094
Pubmed

Mitochondrial calcium overload is a key determinant in heart failure.

RYR2 ITPR2

4.11e-06271226217001
Pubmed

CD133 and BMI1 expressions and its prognostic role in primary glioblastoma.

BMI1 PROM1

4.11e-06271226690524
Pubmed

Requirement for PCNA in DNA mismatch repair at a step preceding DNA resynthesis.

MSH2 PCNA

4.11e-0627128858149
Pubmed

Bmi-1 is essential for the oncogenic potential in CD133(+) human laryngeal cancer cells.

BMI1 PROM1

4.11e-06271226081615
Pubmed

Phosphorylation-dependent regulation of ryanodine receptors: a novel role for leucine/isoleucine zippers.

AKAP6 RYR2

4.11e-06271211352932
Pubmed

Coupling between inositol 1,4,5-trisphosphate receptors and human transient receptor potential channel 1 when intracellular Ca2+ stores are depleted.

TRPC1 ITPR2

4.11e-06271210970773
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

FBXO38 WBP11 CCDC47 PTPRZ1 TBC1D5 PPP1R12B GNL2 PSMC2 MSH2 TRIM13 ITPR2

8.73e-061049711127880917
Pubmed

Cyclic-Nucleotide- and HCN-Channel-Mediated Phototransduction in Intrinsically Photosensitive Retinal Ganglion Cells.

TRPC1 PLCB1 PLCB3

1.06e-052171330270038
Pubmed

Phospholipase C in mouse oocytes: characterization of beta and gamma isoforms and their possible involvement in sperm-induced Ca2+ spiking.

PLCB1 PLCB3

1.23e-0537128687404
Pubmed

The MutSalpha-proliferating cell nuclear antigen interaction in human DNA mismatch repair.

MSH2 PCNA

1.23e-05371218326858
Pubmed

Spectrum and frequencies of mutations in MSH2 and MLH1 identified in 1,721 German families suspected of hereditary nonpolyposis colorectal cancer.

MMRN1 MSH2

1.23e-05371215849733
Pubmed

Molecular portraits of heterogeneity related to cancer stem cells in human ovarian cancer.

BMI1 PROM1

1.23e-05371224300467
Pubmed

BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.

XRN2 CCDC47 LARS1 GNL2 PSMC2 PUM2 MSH2 PPIP5K2 SF3B2 PCNA EIF3CL DHX9

1.35e-051318711230463901
Pubmed

Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages.

PLCB1 PLCB3 ITPR2

1.60e-052471310843712
Pubmed

TNIP2 is a Hub Protein in the NF-κB Network with Both Protein and RNA Mediated Interactions.

PJA2 WBP11 XRN2 CCDC47 WWP2 PSMC2 PUM2 PNISR PCNA DHX9

1.75e-05922711027609421
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

XRN2 CASP14 CCDC47 MCM3AP LARS1 PSMC2 MACF1 MSH2 NEXN SF3B2 PCNA DHX9

1.75e-051353711229467282
Pubmed

An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.

WBP11 CCDC47 GNL2 PUM2 ZDBF2 PPIP5K2 TRIM13 SF3B2 ITPR2

1.81e-0573371934672954
Pubmed

Patterns of expression for the mRNA corresponding to the four isoforms of phospholipase Cbeta in mouse brain.

PLCB1 PLCB3

2.46e-0547129753089
Pubmed

Abnormal taste perception in mice lacking the type 3 inositol 1,4,5-trisphosphate receptor.

PLCB1 ITPR2

2.46e-05471217925404
Pubmed

Dependence of nucleotide substitutions on Ung2, Msh2, and PCNA-Ub during somatic hypermutation.

MSH2 PCNA

2.46e-05471219901081
Pubmed

Phospholipase C-β1 potentiates glucose-stimulated insulin secretion.

PLCB1 PLCB3

2.46e-05471231268747
Pubmed

YB-1 disrupts mismatch repair complex formation, interferes with MutSα recruitment on mismatch and inhibits mismatch repair through interacting with PCNA.

MSH2 PCNA

2.46e-05471224141788
Pubmed

G-protein-activated phospholipase C-beta, new partners for cell polarity proteins Par3 and Par6.

PLCB1 PLCB3

2.46e-05471215782111
Pubmed

Nuclear reorganization of DNA mismatch repair proteins in response to DNA damage.

MSH2 PCNA

2.46e-05471220004149
Pubmed

Phosphoinositide binding specificity among phospholipase C isozymes as determined by photo-cross-linking to novel substrate and product analogs.

PLCB1 PLCB3

2.46e-0547129188725
Pubmed

The hMsh2-hMsh6 complex acts in concert with monoubiquitinated PCNA and Pol η in response to oxidative DNA damage in human cells.

MSH2 PCNA

2.46e-05471221855803
Pubmed

PLCβ isoforms differ in their subcellular location and their CT-domain dependent interaction with Gαq.

PLCB1 PLCB3

2.46e-05471223006664
Pubmed

Hypoxia differently modulates gene expression of inositol 1,4,5-trisphosphate receptors in mouse kidney and HEK 293 cell line.

RYR2 ITPR2

2.46e-05471219120137
Pubmed

SERCA2b and 3 play a regulatory role in store-operated calcium entry in human platelets.

TRPC1 ITPR2

2.46e-05471218068335
Pubmed

Phospholipase C isozymes selectively couple to specific neurotransmitter receptors.

PLCB1 PLCB3

2.46e-0547129305844
Pubmed

Expression of phospholipase C beta family isoenzymes in C2C12 myoblasts during terminal differentiation.

PLCB1 PLCB3

2.46e-05471215174099
Pubmed

Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.

WBP11 INTS7 CCDC47 LARS1 GNL2 PSMC2 MACF1 PLCB3 MSH2 SF3B2 PCNA DHX9

2.72e-051415711228515276
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

FBXO38 XRN2 PUM2 PLCB3 PNISR SF3B2 ZFX EIF3CL DHX9

2.78e-0577471915302935
Pubmed

TIF1γ inhibits lung adenocarcinoma EMT and metastasis by interacting with the TAF15/TBP complex.

LARS1 MSH2 SF3B2 EIF3CL DHX9

3.38e-0517971536261009
Pubmed

A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein.

MSH2 PCNA DHX9

3.52e-053171312171929
Pubmed

Regulatory interactions between the amino terminus of G-protein betagamma subunits and the catalytic domain of phospholipase Cbeta2.

PLCB1 PLCB3

4.09e-05571215611108
Pubmed

N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) triggers MSH2 and Cdt2 protein-dependent degradation of the cell cycle and mismatch repair (MMR) inhibitor protein p21Waf1/Cip1.

MSH2 PCNA

4.09e-05571221725088
Pubmed

Characterization of human exonuclease 1 in complex with mismatch repair proteins, subcellular localization and association with PCNA.

MSH2 PCNA

4.09e-05571214676842
Pubmed

The TRPM7 channel is inactivated by PIP(2) hydrolysis.

PLCB1 PLCB3

4.09e-05571211941371
Pubmed

Genetic variation in genes interacting with BRCA1/2 and risk of breast cancer in the Cypriot population.

RHOBTB2 MSH2 PCNA

4.26e-053371319714462
Pubmed

Genetic mapping of the human and mouse phospholipase C genes.

PLCB1 PLCB3 PCNA

4.26e-05337138672127
Pubmed

Hypertrophic Cardiomyopathy Overview

PDLIM3 NEXN RYR2

4.66e-053471320301725
Pubmed

LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells.

MMRN1 PJA2 SIKE1 XRN2 PPP1R12B SF3B2 PCNA DHX9

4.78e-0563971823443559
Pubmed

WWP2-WWP1 ubiquitin ligase complex coordinated by PPM1G maintains the balance between cellular p73 and ΔNp73 levels.

XRN2 WWP2 PCNA DHX9

4.79e-059771425071155
Pubmed

Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.

CACNA1A SYT11 INTS7 PLCB1 PLCB3 ZFX DHX9

5.31e-0547571731040226
Pubmed

SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.

XRN2 MCM3AP LARS1 GNL2 PUM2 SF3B2 PCNA DHX9

5.68e-0565571835819319
Pubmed

Expression and immunohistochemical localization of eight phospholipase C isoforms in adult male mouse cerebellar cortex.

PLCB1 PLCB3

6.13e-0567128739298
Pubmed

Roles of I(f) and intracellular Ca2+ release in spontaneous activity of ventricular cardiomyocytes during murine embryonic development.

RYR2 ITPR2

6.13e-05671223463619
Pubmed

Isolation and characterization of spheroid cells from human malignant melanoma cell line WM-266-4.

BMI1 PROM1

6.13e-05671219940551
Pubmed

Phospholipase Cε hydrolyzes perinuclear phosphatidylinositol 4-phosphate to regulate cardiac hypertrophy.

AKAP6 RYR2

6.13e-05671223540699
Pubmed

A calcium-induced calcium release mechanism supports luteinizing hormone-induced testosterone secretion in mouse Leydig cells.

RYR2 ITPR2

6.13e-05671220519450
Pubmed

Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging.

RYR2 ITPR2

6.13e-05671225966694
Pubmed

Purification and characterization of membrane-bound phospholipase C specific for phosphoinositides from human platelets.

PLCB1 PLCB3

6.13e-0567122841328
Pubmed

IP3Rs are sufficient for dendritic cell Ca2+ signaling in the absence of RyR1.

RYR2 ITPR2

6.13e-05671216844763
Pubmed

Differential expression profiling of membrane proteins by quantitative proteomics in a human mesenchymal stem cell line undergoing osteoblast differentiation.

CCDC47 PSMC2 DHX9

7.63e-054071316210410
Pubmed

Calmodulin is a phospholipase C-beta interacting protein.

PLCB1 PLCB3

8.57e-05771212821674
Pubmed

A defined human system that supports bidirectional mismatch-provoked excision.

MSH2 PCNA

8.57e-05771215225546
Pubmed

Developmental expression of the calcium release channels during early neurogenesis of the mouse cerebral cortex.

RYR2 ITPR2

8.57e-05771211860456
Pubmed

Genetic dissection of gustatory sensitivity to bitterness (sucrose octaacetate) in mice.

PLCB1 PLCB3

8.57e-05771210609087
Pubmed

Receptor-like protein tyrosine phosphatase zeta/RPTP beta is expressed on tangentially aligned neurons in early mouse neocortex.

PTPRZ1 PCNA

8.57e-05771214757526
Pubmed

ATG5 is required for B cell polarization and presentation of particulate antigens.

DOCK2 XRN2 CCDC47 LARS1 PNISR EIF3CL DHX9 ITPR2

9.10e-0570171830196744
Pubmed

Maintenance of silent chromatin through replication requires SWI/SNF-like chromatin remodeler SMARCAD1.

MSH2 SF3B2 PCNA DHX9

9.61e-0511671421549307
Pubmed

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

AKAP6 RHOBTB2 PLCB1 PUM2 MACF1

9.97e-0522571512168954
Pubmed

Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.

CACNA1A PJA2 SYT11 KCNJ3 PLCB1 PSMC2 MACF1 ZDBF2 RYR2 EIF3CL

1.03e-041139711036417873
Pubmed

Matrix-screening reveals a vast potential for direct protein-protein interactions among RNA binding proteins.

BMI1 WBP11 XRN2 GNL2 PUM2 SF3B2 EIF3CL DHX9

1.13e-0472371834133714
Pubmed

METTL3 protects METTL14 from STUB1-mediated degradation to maintain m6 A homeostasis.

LARS1 PSMC2 PUM2 MSH2 EIF3CL

1.13e-0423171536597993
Pubmed

A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cells.

PDLIM3 CCDC47 MCM3AP GNL2

1.13e-0412171422412018
Pubmed

GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain.

PLCB1 PLCB3

1.14e-0487129651375
Pubmed

Roles of IP3R and RyR Ca2+ channels in endoplasmic reticulum stress and beta-cell death.

RYR2 ITPR2

1.14e-04871219033399
Pubmed

Optimized fragmentation schemes and data analysis strategies for proteome-wide cross-link identification.

LARS1 PSMC2 MACF1 NEXN SF3B2 PCNA DHX9

1.15e-0453871728524877
Pubmed

N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.

PDLIM3 TBC1D5 LARS1 GNL2 PSMC2 PUM2 MACF1 SF3B2 PCNA

1.17e-0493471933916271
Pubmed

USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.

FBXO38 XRN2 MACF1 SF3B2 DHX9

1.20e-0423471536243803
Pubmed

TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1.

XRN2 PPP1R12B LARS1 GNL2 NEXN SF3B2 MYO5C EIF3CL DHX9

1.32e-0494971936574265
Pubmed

Exogenous human immunodeficiency virus type-1 Tat protein selectively stimulates a phosphatidylinositol-specific phospholipase C nuclear pathway in the Jurkat T cell line.

PLCB1 PLCB3

1.47e-0497127589147
Pubmed

Praja1, a novel gene encoding a RING-H2 motif in mouse development.

PJA2 ZFX

1.47e-0497129393880
Pubmed

The SNF2-like helicase HELLS mediates E2F3-dependent transcription and cellular transformation.

MSH2 PCNA

1.47e-04971222157815
Pubmed

Reactivity of anti-proliferating cell nuclear antigen (PCNA) murine monoclonal antibodies and human autoantibodies to the PCNA multiprotein complexes involved in cell proliferation.

PCNA DHX9

1.47e-04971211254741
Pubmed

Identification of DNA replication and cell cycle proteins that interact with PCNA.

PCNA DHX9

1.47e-0497129396813
Pubmed

Involvement of inositol 1,4,5-trisphosphate-regulated stores of intracellular calcium in calcium dysregulation and neuron cell death caused by HIV-1 protein tat.

PLCB1 PLCB3

1.47e-04971210501179
Pubmed

Feedback regulation of transcriptional termination by the mammalian circadian clock PERIOD complex.

XRN2 DHX9

1.47e-04971222767893
Pubmed

Expression of phospholipase C isozymes by murine B lymphocytes.

PLCB1 PLCB3

1.83e-04107122033248
Pubmed

Implantation failure in mice with a disruption in Phospholipase C beta 1 gene: lack of embryonic attachment, aberrant steroid hormone signalling and defective endocannabinoid metabolism.

PLCB1 PLCB3

1.83e-041071223295235
Pubmed

The mammalian TRIM-NHL protein TRIM71/LIN-41 is a repressor of mRNA function.

XRN2 PUM2

1.83e-041071223125361
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

PJA2 SYT11 RHOBTB2 MCM3AP PUM2 MACF1

1.87e-0440771612693553
Pubmed

Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.

DOCK2 XRN2 PSMC2 MACF1 MSH2 SF3B2 DHX9

1.87e-0458271720467437
Pubmed

Widespread macromolecular interaction perturbations in human genetic disorders.

BMI1 PDLIM3 INTS7 WWP2 TRIM54 CFAP206 RXRG

2.03e-0459071725910212
Pubmed

rec-YnH enables simultaneous many-by-many detection of direct protein-protein and protein-RNA interactions.

XRN2 PSMC2 SF3B2 PCNA

2.09e-0414271430217970
Pubmed

Absence of PTHrP nuclear localization and carboxyl terminus sequences leads to abnormal brain development and function.

BMI1 PCNA

2.23e-041171222844494
Pubmed

GANP regulates recruitment of AID to immunoglobulin variable regions by modulating transcription and nucleosome occupancy.

MCM3AP DHX9

2.23e-041171223652018
Pubmed

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.

WBP11 XRN2 GNL2 PUM2 MACF1 PNISR SF3B2 DHX9

2.38e-0480771822681889
GeneFamilyPhospholipases|C2 domain containing phospholipases

PLCB1 PLCB3

1.56e-0319562832
GeneFamilyRing finger proteins

BMI1 PJA2 TRIM54 BFAR TRIM13

1.59e-0327556558
CoexpressionENK_UV_RESPONSE_KERATINOCYTE_DN

SEMA3F BMI1 PTPRZ1 MCM3AP CD58 PUM2 MACF1 TRIM13 DHX9

5.95e-06481719M3898
CoexpressionCYCLIN_D1_UP.V1_DN

AKAP6 GUCY2C KCNJ3 PUM2 RXRG EPHA1

1.30e-05190716M2652
CoexpressionGSE26290_CTRL_VS_AKT_INHIBITOR_TREATED_ANTI_CD3_AND_IL2_STIM_CD8_TCELL_UP

CACNA1A SIKE1 SERPINB9 GUCY2C CYP2U1 PLCB3

1.55e-05196716M8135
CoexpressionGSE3982_MAC_VS_TH2_UP

FBXO38 TBC1D5 RHOBTB2 DNAH17 ZKSCAN3 ITPR2

1.69e-05199716M5513
CoexpressionBOYAULT_LIVER_CANCER_SUBCLASS_G2

INTS7 CD58 EPHA1

5.94e-0528713M10953
CoexpressionVALK_AML_CLUSTER_1

MMRN1 BMI1 PROM1

6.62e-0529713M19844
CoexpressionBENPORATH_ES_1

PROM1 PTPRZ1 PLCB3 MSH2 TEAD4 PNISR EPHA1

7.51e-05379717M1871
ToppCellLA-03._Atrial_Cardiomyocyte|LA / Chamber and Cluster_Paper

AKAP6 PDLIM3 KCNJ3 PPP1R12B TRIM54 NEXN RYR2

2.35e-081917175d1b674eb7703830b7ce8bbeac3363cabd0e6ae9
ToppCellCOVID-19-Heart-CM_2|COVID-19 / Disease (COVID-19 only), tissue and cell type

AKAP6 PDLIM3 PPP1R12B TRIM54 NEXN RYR2

5.11e-07185716549eeb521c3985bff396ea0f202db21822efa51f
ToppCellfacs-Heart-Unknown-3m-Mesenchymal|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AKAP6 KCNJ3 TRIM54 NEXN RXRG RYR2

5.44e-071877160ffb988e0da2c7205c3515eca8e9851739bff5c5
ToppCellfacs-Heart-Unknown|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AKAP6 KCNJ3 TRIM54 NEXN RXRG RYR2

5.44e-07187716362e56426a568423a81e8a30e3ecf99b76135843
ToppCellfacs-Heart-Unknown-3m|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AKAP6 KCNJ3 TRIM54 NEXN RXRG RYR2

5.44e-07187716c004567767b89f3d89f5c7b28d952f3445957e1e
ToppCellLA-03._Atrial_Cardiomyocyte|World / Chamber and Cluster_Paper

AKAP6 PDLIM3 KCNJ3 PPP1R12B NEXN RYR2

5.62e-071887166d249fe92d51a19da19ec14bb2262d394255d577
ToppCellLA-13._Vascular_Smooth_Muscle|LA / Chamber and Cluster_Paper

AKAP6 PDLIM3 PPP1R12B MACF1 NEXN RYR2

5.62e-0718871634e1b074a3995aa46ab194eb45115d76d1a5514d
ToppCellLPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

AKAP6 PROM1 PDLIM3 PPP1R12B NEXN RYR2

5.62e-07188716293f2fa99f5f96aa7fd2b2a5cc94ff60eeaabe11
ToppCellCOVID-19-Heart|COVID-19 / Disease (COVID-19 only), tissue and cell type

AKAP6 PDLIM3 PLCB1 TRIM54 NEXN RYR2

5.97e-07190716918ad5037881212008f9f69d5df5da91fd01422c
ToppCellCOVID-19-Heart-CM_+_EC_+_Pericyte|Heart / Disease (COVID-19 only), tissue and cell type

AKAP6 PDLIM3 PPP1R12B TRIM54 NEXN RYR2

6.55e-07193716dd5378a1ef8eb0eda9a3aae62f3c2f3a1402bda0
ToppCellRA-03._Atrial_Cardiomyocyte|World / Chamber and Cluster_Paper

AKAP6 PDLIM3 KCNJ3 PPP1R12B NEXN RYR2

6.75e-0719471689812fb164065041357bb37a3c2d87028ec3de4e
ToppCellCOVID-19-Heart-CM_1|Heart / Disease (COVID-19 only), tissue and cell type

AKAP6 PDLIM3 PPP1R12B TRIM54 NEXN RYR2

6.95e-07195716f1ef50331eda8f1239dba6ea970df4eaccf032f1
ToppCellCOVID-19-Heart-CM_2|Heart / Disease (COVID-19 only), tissue and cell type

AKAP6 PDLIM3 PPP1R12B TRIM54 NEXN RYR2

6.95e-0719571675fc81bddb246dca3b437fb60827b1d4fe416405
ToppCell5'-Adult-SmallIntestine-Mesenchymal-Pericytes-Contractile_pericyte_(PLN+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

AKAP6 SERPINI1 PDLIM3 PPP1R12B NEXN RYR2

7.16e-07196716ce6f7ddb8104471dc90347f427486379914d63b4
ToppCell5'-Adult-SmallIntestine-Mesenchymal-Pericytes|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

AKAP6 SERPINI1 PDLIM3 PPP1R12B NEXN RYR2

7.16e-071967166d7179decea512dd49bb2d5f6a4f5989349d52a9
ToppCell5'-Adult-LargeIntestine-Mesenchymal-Pericytes-Contractile_pericyte_(PLN+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

AKAP6 SERPINI1 PDLIM3 PPP1R12B NEXN RYR2

7.38e-07197716d16bb765afdc02406ffd7ce6a75bae72b66db66c
ToppCellTracheal-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_pulmonary|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

AKAP6 PDLIM3 KCNJ3 TEAD4 NEXN RYR2

7.38e-07197716ac4f53acb2f8a428b0f2fab3c30a34e095a1bed7
ToppCell5'-Adult-LargeIntestine-Mesenchymal-Pericytes|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

AKAP6 SERPINI1 PDLIM3 PPP1R12B NEXN RYR2

7.38e-0719771668c23c23b6924892f4c238cf2f5abc7927e04fbc
ToppCellLPS_only-Mesenchymal_myocytic|LPS_only / Treatment groups by lineage, cell group, cell type

AKAP6 PROM1 PDLIM3 PPP1R12B NEXN RYR2

8.06e-072007168bc9923f82bfb836e2f524204c92050edeae8ca5
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

AKAP6 SERPINI1 PPP1R12B RYR2 EIF3CL

4.48e-061527150cb5f4dfae04e3f4eba502bbf229007d5fa3884d
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

AKAP6 SERPINI1 PPP1R12B RYR2 EIF3CL

4.48e-06152715ba89ffb5a8bb33c188f854f54b39123b6d73496a
ToppCellTCGA-Bone_and_Soft_Tissue-Primary_Tumor-Sarcoma-Conventional_Leiomyosarcoma|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9

AKAP6 PDLIM3 PPP1R12B NEXN RYR2

4.63e-06153715ec6fe6b8c884fa76adc7a0f9db041f7b1567a2ee
ToppCellCOVID-19-Heart-CM_+_Macrophage|COVID-19 / Disease (COVID-19 only), tissue and cell type

AKAP6 PDLIM3 TRIM54 NEXN RYR2

7.73e-061707153f15242a1d3e4e9871d9170b2ef05842fb609c29
ToppCellfacs-Heart-Unknown-3m-Mesenchymal-atrial_myocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AKAP6 KCNJ3 TRIM54 NEXN RYR2

8.18e-06172715ee8ce9e8c9a6d3ee2be113f77743958005f4b3f0
ToppCellfacs-Heart-Unknown-3m-Mesenchymal-atrial_cardiomyocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AKAP6 KCNJ3 TRIM54 NEXN RYR2

8.18e-06172715bd468a7ea6ec832dcf6a816a1e0c03fa0f176dad
ToppCellnucseq-Mesenchymal-Fibroblastic-Fibroblastic_2-ASMC|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

AKAP6 PDLIM3 PPP1R12B NEXN RYR2

8.41e-06173715cb6389536195443633adb06e5f1b7483530773d1
ToppCellPND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC-VSMC_prolif|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

AKAP6 SERPINI1 PTPRZ1 NEXN PCNA

8.41e-061737155c55e1e27e9e3e77600d378cc87b51cc73907527
ToppCellCOVID-19-Heart-CM_3|COVID-19 / Disease (COVID-19 only), tissue and cell type

AKAP6 PDLIM3 TRIM54 NEXN RYR2

9.14e-061767159df7a124ebafb0087da0cda133a394275d7bed81
ToppCelldroplet-Heart-nan-3m|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AKAP6 KCNJ3 MACF1 RYR2 DHX9

9.14e-06176715749b47eac5436fa34e0d243ffbc6f1897f4e431e
ToppCellfacs-Trachea-18m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l39|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

AKAP6 SERPINI1 PDLIM3 PPP1R12B NEXN

9.40e-06177715928118b0ed120ec01c7d753ce523ab609ac24e5f
ToppCelldroplet-Heart-nan-3m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AKAP6 SERPINI1 PDLIM3 PPP1R12B NEXN

9.40e-06177715dbdbdc8ed9ef0b529694242ef9f9f07a42e16005
ToppCellCOVID-19-Heart-CM_+_EC_+_Pericyte|COVID-19 / Disease (COVID-19 only), tissue and cell type

AKAP6 PDLIM3 TRIM54 NEXN RYR2

1.05e-05181715719eb532453ab7cd7893726885bc75d74a10b21e
ToppCellCOVID-19-Heart-CM_4|COVID-19 / Disease (COVID-19 only), tissue and cell type

AKAP6 PDLIM3 TRIM54 NEXN RYR2

1.10e-051837152902b6e8aa9a6f62bc1a792c971ab7f651a8e676
ToppCellCOVID-19-Heart-CM_1|COVID-19 / Disease (COVID-19 only), tissue and cell type

AKAP6 PDLIM3 TRIM54 NEXN RYR2

1.13e-05184715e737f0f14c49b07bbb04a165083ac32210bc5690
ToppCellLPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

AKAP6 PROM1 PDLIM3 PPP1R12B NEXN

1.19e-051867156add08d4ca019ff2864acdd5ec2c66a59a574591
ToppCellCOVID-19-Fibroblasts-Airway_smooth_muscle|COVID-19 / group, cell type (main and fine annotations)

AKAP6 PDLIM3 PPP1R12B NEXN RYR2

1.23e-05187715464a0c3b92b778911b5f9cd73642e09e3472063a
ToppCelldroplet-Lung-nan-18m-Mesenchymal-Airway_Smooth_Muscle|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AKAP6 PDLIM3 PTPRZ1 NEXN RYR2

1.26e-0518871561f010c165826b434ca3d27553d4c9e13d2c0c51
ToppCelldroplet-Lung-nan-18m-Mesenchymal-bronchial_smooth_muscle_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AKAP6 PDLIM3 PTPRZ1 NEXN RYR2

1.26e-051887157553ef7de3575af4cf34704b405b551c1af8eb83
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

AKAP6 PDLIM3 PPP1R12B NEXN RYR2

1.29e-05189715127ad2ba3e794df8cce2eee3e4171bccb5aad51b
ToppCellLPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PROM1 PDLIM3 PPP1R12B NEXN RYR2

1.29e-051897157ab1cfc1657277858339f7258a0c4ae9cb42fdf8
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

AKAP6 PDLIM3 PPP1R12B NEXN RYR2

1.29e-051897152cfb4d12f75678d1619f4743838a0e954bd57761
ToppCellNon-neuronal-Non-dividing-Radial_Glia-oRG/Astrocyte-7|World / Primary Cells by Cluster

PDLIM3 SYT11 PTPRZ1 VEPH1 CD58

1.32e-051907158f1c490dd8e5f80382f5294fd1aa8cba4c3c647f
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

AKAP6 PDLIM3 PPP1R12B NEXN RYR2

1.32e-05190715562ee3b025c29edf07b8b344323edb49d82f1c7e
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

AKAP6 PDLIM3 PPP1R12B NEXN RYR2

1.32e-05190715f5fb989afabb49d64d91324570cd8c80a4b9e67d
ToppCellNon-neuronal-Non-dividing-Radial_Glia-oRG/Astrocyte|World / Primary Cells by Cluster

PDLIM3 SYT11 PTPRZ1 VEPH1 CD58

1.32e-051907157dbfd543398c63cbe1e68b54bcb5e2291f521935
ToppCelldroplet-Limb_Muscle-Pre-Sort-18m-Mesenchymal-smooth_muscle_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AKAP6 SERPINI1 PDLIM3 NEXN RYR2

1.36e-051917158e8beb8e8a3b33cac83d3f7ce915a71e3654fdab
ToppCellLPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PROM1 PDLIM3 PPP1R12B NEXN RYR2

1.36e-051917157853ac7dff649150e6ff27cd4c8cf7c1fc034ed4
ToppCelldroplet-Heart-nan-3m-Mesenchymal-atrial_cardiomyocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AKAP6 KCNJ3 TRIM54 NEXN RYR2

1.36e-0519171597fb4232417a39801e87725755fd16a57c250209
ToppCelldroplet-Limb_Muscle-Pre-Sort-18m-Mesenchymal-unknown|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AKAP6 SERPINI1 PDLIM3 NEXN RYR2

1.36e-0519171560bc1f3efa7bbad5cb7944fe5e049ea79cd1745a
ToppCelldroplet-Heart-nan-3m-Mesenchymal-cardiomyocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AKAP6 KCNJ3 TRIM54 NEXN RYR2

1.36e-0519171564070a309d7e3f6001272409ab9ce206d0e7d73f
ToppCellLPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PROM1 PDLIM3 PPP1R12B PLCB1 RYR2

1.39e-05192715992d08092edbc68c47b945deb8708379738c239a
ToppCell368C-Fibroblasts-Fibroblast-K_(Pericytes)|368C / Donor, Lineage, Cell class and subclass (all cells)

AKAP6 SERPINI1 PDLIM3 PPP1R12B NEXN

1.43e-051937155182284dfa7c94027e94172e08f78c86b95d63f4
ToppCell368C-Fibroblasts-Fibroblast-K_(Pericytes)-|368C / Donor, Lineage, Cell class and subclass (all cells)

AKAP6 SERPINI1 PDLIM3 PPP1R12B NEXN

1.43e-051937154f7bab0115469c855160636d168bd6e5d4e2dd2f
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

AKAP6 PDLIM3 PPP1R12B NEXN RYR2

1.46e-051947155c3b2b05d1e4f146551fe4c920263d8e6ca34de3
ToppCellRA-03._Atrial_Cardiomyocyte|RA / Chamber and Cluster_Paper

AKAP6 KCNJ3 PPP1R12B NEXN RYR2

1.46e-05194715c3535f7cc0076653c72db582047cff053c322397
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

AKAP6 PDLIM3 PPP1R12B NEXN RYR2

1.46e-05194715ab9cad697f9209d2889bc02b43b502dfeb2ebfef
ToppCellLA-09._Endothelium_I|World / Chamber and Cluster_Paper

MMRN1 SEMA3F ICAM2 PLCB1 TEAD4

1.50e-05195715fc95457a298b5d0dab687d9ee7e225a7f7b9a0d4
ToppCellBronchial-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_airway_ASM|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

AKAP6 PDLIM3 KCNJ3 NEXN RYR2

1.54e-051967159830fb3da7a60f65ad463e9054bb77c06b025e4d
ToppCellCOVID-19-Heart-Mito_CM|COVID-19 / Disease (COVID-19 only), tissue and cell type

AKAP6 PDLIM3 TRIM54 NEXN RYR2

1.58e-0519771544e49943d62bfe622b40ad0460093d31540544df
ToppCellParenchymal-NucSeq-Stromal-Myofibroblastic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

AKAP6 PDLIM3 PLCB1 NEXN RYR2

1.61e-05198715bd42c03e384e64f61b02618cf1a5440033bb04b2
ToppCellTracheal-NucSeq-Stromal-Myofibroblastic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

AKAP6 PDLIM3 KCNJ3 NEXN RYR2

1.61e-05198715c12e7511628db819a52959bb68580e27c00c2e41
ToppCellTracheal-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_airway_ASM|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

AKAP6 PDLIM3 KCNJ3 NEXN RYR2

1.61e-0519871522e766df1276c5b14aa0d83f434f47140ebb98ea
ToppCellSepsis-ICU-NoSEP-Myeloid-tDC|ICU-NoSEP / Disease, condition lineage and cell class

PROM1 CYP2U1 ZDBF2 RWDD2B TRIM13

1.65e-0519971590ddd686b8f39c6f6134b9b048396cebcf8d0448
ToppCellBronchus_Control_(B.)-Stromal-TX-Smooth_muscle-2|Bronchus_Control_(B.) / Sample group, Lineage and Cell type

SERPINI1 PDLIM3 NEXN RXRG RYR2

1.65e-051997152c5ad62919c64ea0242e0984bb9932d2d975f4e3
ToppCellParenchymal-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_pulmonary|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

AKAP6 PDLIM3 PLCB1 NEXN RYR2

1.65e-05199715b1753474152b82a0b811b9878c890a359e14919a
ToppCellControl_saline-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast|Control_saline / Treatment groups by lineage, cell group, cell type

PROM1 PDLIM3 PPP1R12B NEXN RYR2

1.69e-05200715c5e051f1aac8dda376c342a9932785a23450e073
ToppCellLPS_anti-TNF-Mesenchymal_myocytic-Pericyte-Pericyte_3|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

AKAP6 PDLIM3 PPP1R12B NEXN RYR2

1.69e-052007159169a9ec8e9ab95d90a64c5a19ac666a5cf82313
ToppCellLPS_IL1RA_TNF-Mesenchymal_myocytic|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

AKAP6 PROM1 PDLIM3 PPP1R12B NEXN

1.69e-05200715f599e4b051ac3dad11ad437e98dc8ea6754cca53
ToppCellControl_saline-Mesenchymal_myocytic-Myofibroblastic|Control_saline / Treatment groups by lineage, cell group, cell type

PROM1 PDLIM3 PPP1R12B NEXN RYR2

1.69e-052007159d5b3c2dcfa55d50acc2ce2c319d51aa525d4cd1
ToppCellControl_saline-Mesenchymal_myocytic|Control_saline / Treatment groups by lineage, cell group, cell type

PROM1 PDLIM3 PPP1R12B NEXN RYR2

1.69e-052007155ed4261157cd51109b314818133ac3a0d34ee5fa
ToppCellLPS_IL1RA_TNF-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

PROM1 PDLIM3 PPP1R12B PLCB1 NEXN

1.69e-0520071509537dc25f8b8b4654a7c183827ee1522a41a4e0
ToppCellLPS_IL1RA-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

PROM1 PDLIM3 PPP1R12B NEXN RYR2

1.69e-052007158988f113708eef7d9d2a6a6c1bcfd7c8f9804d3e
ToppCellLPS_anti-TNF-Mesenchymal_myocytic|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

PROM1 PDLIM3 PPP1R12B NEXN RYR2

1.69e-0520071567dcbd86fbc79fd585d0793f979e4aac100326c9
ToppCellLPS_only-Mesenchymal_myocytic-Pericyte|LPS_only / Treatment groups by lineage, cell group, cell type

AKAP6 PDLIM3 PPP1R12B NEXN RYR2

1.69e-052007158c8ef2b19ab5b1bfc0fae6c38a330f464f28e86f
ToppCellBrain_organoid-organoid_Tanaka_cellReport-3m-Mesenchymal-Mesoderm|3m / Sample Type, Dataset, Time_group, and Cell type.

PDLIM3 TRIM54 TEAD4 NEXN RXRG

1.69e-05200715538ae964db58c4acafe93f735b3e03fc08fdaac6
ToppCellLPS_IL1RA_TNF-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

AKAP6 PROM1 PDLIM3 PPP1R12B NEXN

1.69e-05200715dcdaec3ca3a3024dc1b8788c417003f84c2bffdc
ToppCellControl_saline-Mesenchymal_myocytic-Pericyte-Pericyte_3|Control_saline / Treatment groups by lineage, cell group, cell type

AKAP6 PDLIM3 PPP1R12B NEXN RYR2

1.69e-05200715b0866b497aa71d06cef25f9a335fa584e95fa7e0
ToppCellLPS_only-Mesenchymal_myocytic-Pericyte-Pericyte_3|LPS_only / Treatment groups by lineage, cell group, cell type

AKAP6 PDLIM3 PPP1R12B NEXN RYR2

1.69e-052007157c62678cf408aaaf98d6df0fb27814d2007c4521
ToppCellLPS_IL1RA-Mesenchymal_myocytic|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

AKAP6 PROM1 PDLIM3 PPP1R12B NEXN

1.69e-0520071577631c471cc5d453a749784f838cfa6408caf09b
ToppCellRV-03._Atrial_Cardiomyocyte|World / Chamber and Cluster_Paper

AKAP6 PPP1R12B NEXN RYR2

4.34e-051227141cb1dd03b2aaedbe04f3ed907568c3b7f54767b3
ToppCellLPS-IL1RA-Endothelial-Epi-like-Alv_Cap|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SERPINB9 EFCAB6 EPHA1 MYO5C

7.02e-051387145f8ac8f67e34a7cf560099208e6884102532391e
ToppCellAT1-AT2_cells-Donor_04|World / lung cells shred on cell class, cell subclass, sample id

CACNA1A PDLIM3 NBEAL2 NEXN

7.42e-0514071445d52a086ced8d58e01ac51ac4a90338e8649b16
ToppCellprimary_visual_cortex|World / Per Region, Lineage, Cell class, Cell type, Cell subtype

SEMA3F SCG2 ZDBF2 PNISR

7.63e-05141714605d7b28e99c943f64b4095855a6f9f70e92cb09
ToppCellileum-BEST4+_Enterocytes|ileum / shred on tissue and cell subclass

VEPH1 PLCB1 MYO5C ITPR2

1.07e-04154714608e9c982125e0c2c15b86b1920813845a0db81f
ToppCellAdult-Mesenchymal-vascular_smooth_muscle_cell-D231|Adult / Lineage, Cell type, age group and donor

AKAP6 SERPINI1 PDLIM3 RYR2

1.18e-041587148d64c0c9de910a3f4658778642d183c8b9b6f6a2
ToppCellAdult-Mesenchymal-vascular_smooth_muscle_cell-D122|Adult / Lineage, Cell type, age group and donor

AKAP6 PDLIM3 PLCB1 RYR2

1.24e-04160714fd14dfeb7021a4b7299371854dc8fc1fd66c8dae
ToppCellPND14-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PDLIM3 PTPRZ1 PPP1R12B NEXN

1.24e-041607148624f101828efd32cdd38a65df8d94d690720a63
ToppCellPND14-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC-ASMC_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PDLIM3 PTPRZ1 PPP1R12B NEXN

1.24e-041607149de3dd6b9d4b51314d60b3b01f4132bcfa2dfc18
ToppCellP07-Mesenchymal-developing_mesenchymal_cell-mesenchymal_immature_unknown_1|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

PROM1 MACF1 NEXN EPHA1

1.27e-04161714b19f82dd98a3064581793711bb70373f18abecd9
ToppCellPND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_prolif|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PDLIM3 CYP2U1 NEXN PCNA

1.30e-041627143f264263878af630921911c2b344ac56eb1e7099
ToppCellfacs-Marrow-B-cells-24m-Myeloid-granulocyte_monocyte_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CASP14 ZDBF2 TEAD4 RYR2

1.40e-041657146d315e0734079ad05336cc2c3f24d870c9105bc8
ToppCellfacs-Marrow-B-cells-24m-Myeloid-granulocyte_monocyte_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CASP14 ZDBF2 TEAD4 RYR2

1.40e-0416571484f5597b1bb75f42de9a224196bb8ac198bbe3bf
ToppCellfacs-Marrow-B-cells-24m-Myeloid-basophil|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1A SCG2 DNAH17 ARMH3

1.43e-0416671413027ae342994db4540e64eb910df1f42b160931
ToppCellfacs-Marrow-B-cells-24m-Myeloid-basophil|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1A SCG2 DNAH17 ARMH3

1.43e-04166714b21e45bd43f26149b9cd6e45c19241c82d54fb2f
ToppCell368C-Myeloid-Monocyte-CD16+_Monocyte|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

EFCAB6 RHOBTB2 MCM3AP MYO5C

1.47e-04167714dbd2b9f2f4ba7be5fdf8318094e6b078cb1d1c43
ToppCellCTRL-Myeloid-Monocyte|CTRL / Disease state, Lineage and Cell class

SERPINB9 SCG2 PLCB1 MEFV

1.50e-0416871413dca90c7b811e4d5e8fa44f5e892e29be9787a6
ToppCellE18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_prolif|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MACF1 NEXN PCNA EPHA1

1.53e-0416971416c52a0f6d96ecc1832922fce9b39691849f0d73
ToppCellCOVID-19-Heart-CM_+_Macrophage|Heart / Disease (COVID-19 only), tissue and cell type

AKAP6 DOCK2 NEXN RYR2

1.57e-041707144232fe937909f93d3736988c707b8f95ce993398
ToppCell368C-Myeloid-Monocyte-CD16+_Monocyte|Monocyte / Donor, Lineage, Cell class and subclass (all cells)

EFCAB6 RHOBTB2 MCM3AP MYO5C

1.57e-041707144a19c7e3bb0f9c2601a10debe7000066789b4150
ToppCellAdult-Mesenchymal-vascular_smooth_muscle_cell|Adult / Lineage, Cell type, age group and donor

AKAP6 PDLIM3 PLCB1 RYR2

1.64e-04172714c62cad0f4212d1e9ea1ec3143ad3c4e06aff0ebf
DrugSeneciphylline [480-81-9]; Down 200; 12uM; MCF7; HT_HG-U133A

SIKE1 KCNJ3 TBC1D5 MCM3AP PLCB1 PLCB3 ZFX DHX9 ITPR2

6.50e-091897092797_DN
DrugCefamandole sodium salt [30034-03-8]; Up 200; 8.2uM; MCF7; HT_HG-U133A

SEMA3F KCNJ3 TRPC1 MCM3AP PLCB1 PLCB3 EPHA1

2.55e-061987073436_UP
DrugSuprofen [40828-46-4]; Down 200; 15.4uM; PC3; HT_HG-U133A

SEMA3F RHOBTB2 DNAH17 PLCB3 RYR2 ZFX ITPR2

2.55e-061987074005_DN
DrugMetformin hydrochloride [1115-70-4]; Up 200; 24.2uM; MCF7; HT_HG-U133A

SEMA3F FBXO38 NBEAL2 TBC1D5 PPP1R12B PLCB1 DHX9

2.55e-061987071694_UP
DrugLorglumide sodium salt [97964-56-2]; Down 200; 8.4uM; MCF7; HT_HG-U133A

KCNJ3 MCM3AP PLCB1 ZFX DHX9 ITPR2

2.55e-051897065254_DN
Drugpiperaquine

LARS1 MSH2

2.79e-053702CID000122262
DrugGriseofulvin [126-07-8]; Down 200; 11.2uM; HL60; HT_HG-U133A

SEMA3F SYT11 TBC1D5 ICAM2 MACF1 RWDD2B

2.87e-051937062332_DN
Drug(+,-)-Synephrine [94-07-5]; Down 200; 24uM; MCF7; HT_HG-U133A

SIKE1 KCNJ3 PLCB1 PLCB3 TEAD4 EPHA1

3.13e-051967066798_DN
Drug(-)-Adenosine 3',5'-cyclic monophosphate [60-92-4]; Up 200; 12.2uM; MCF7; HT_HG-U133A

PTPRZ1 NBEAL2 PPP1R12B TRPC1 ZKSCAN3 EPHA1

3.13e-051967065533_UP
DrugHemicholinium bromide [312-45-8]; Down 200; 7uM; MCF7; HT_HG-U133A

KCNJ3 PPP1R12B MCM3AP PLCB1 RYR2 ITPR2

3.22e-051977063216_DN
DrugBAPTA-AM

CACNA1A CASP14 KCNJ3 SCG2 TRPC1 PLCB1 PLCB3

3.26e-05293707CID000002293
DrugTrioxsalen [3902-71-4]; Up 200; 17.6uM; MCF7; HT_HG-U133A

CACNA1A PDLIM3 TBC1D5 TRPC1 DNAH17 ZFX

3.31e-051987066216_UP
DrugGraveoline [485-61-0]; Down 200; 14.4uM; MCF7; HT_HG-U133A

SEMA3F INTS7 KCNJ3 PLCB1 RYR2 ITPR2

3.50e-052007066034_DN
DrugPirlindole mesylate [60762-57-4]; Up 200; 12.4uM; MCF7; HT_HG-U133A

AKAP6 PDLIM3 KCNJ3 TBC1D5 TRPC1 MCM3AP

3.50e-052007065497_UP
Diseaseobesity (implicated_via_orthology)

GUCY2C TBC1D5 PLCB1 PUM2 PLCB3 ITPR2

1.35e-05215716DOID:9970 (implicated_via_orthology)
Diseaseverbal-numerical reasoning measurement

AKAP6 DOCK2 WWP2 ARMH3

2.86e-04131714EFO_0008394
DiseaseColorectal Neoplasms

PROM1 GUCY2C ZKSCAN3 MSH2 EPHA1

5.52e-04277715C0009404
DiseaseColorectal Carcinoma

AKAP6 PROM1 GUCY2C MCM3AP ZKSCAN3 MSH2 EPHA1

1.49e-03702717C0009402
DiseaseVitiligo

SERPINB9 PLCB3 MSH2

1.88e-03101713EFO_0004208
DiseaseHematopoetic Myelodysplasia

BMI1 PLCB1

2.22e-0329712C2713368
Diseasemyelodysplastic syndrome (is_implicated_in)

PLCB1 MEFV

2.38e-0330712DOID:0050908 (is_implicated_in)

Protein segments in the cluster

PeptideGeneStartEntry
VMDDQTQGSDPYIKM

SYT11

186

Q9BT88
ITFQEQGDKMMEEYS

CACNA1A

1511

O00555
PYGEMSNQEVMKSIE

EPHA1

826

P21709
VLMYDEIFMTEDPSK

ARMH3

26

Q5T2E6
PSLDTIKMQVYFDMN

CFAP206

76

Q8IYR0
TPMEVVDMLNDIYKS

GUCY2C

841

P25092
YKIPIDNMTNEMEQR

INTS7

866

Q9NVH2
ANYVVQKMIDMAEPA

PUM2

1001

Q8TB72
QIPYEKNDEKMNEVM

ITPR2

1221

Q14571
MVVDDDSPEMYKTIS

NEXN

351

Q0ZGT2
QEEMDTVMKDPYKVV

GNL2

96

Q13823
DEYEMESPNITDTMK

CD58

101

P19256
GDPEVMQKMTDQVNY

MMRN1

316

Q13201
MDYLVTQIMDQKEGS

MCM3AP

701

O60318
SKMDIPNTFQIDVMY

BMI1

181

P35226
QIKVTMNDEDMDTYV

CCDC47

246

Q96A33
PNQEKVSDYEMKLMD

PCNA

106

P12004
MMESTFPQQKDLDQV

VEPH1

661

Q14D04
QTFMEEMTRKQPDVD

MACF1

3051

O94854
VIMMKENEYQASSVP

MEFV

691

O15553
SESTVMPNMYDNVNK

PTPRZ1

1066

P23471
MEQLTKSPMEFVEYN

PLCB3

626

Q01970
EIPEEMTADETKDYM

FBXO38

16

Q6PIJ6
DKAQMPYTEATIMEV

CYP2U1

396

Q7Z449
RMDEEFTKIMQNTDP

EIF3CL

451

B5ME19
MEEPQKSYVNTMDLE

BFAR

1

Q9NZS9
QLYEGKEQMEFEESM

DOCK2

756

Q92608
IDDMNMPEVDKYGTV

DNAH17

2521

Q9UFH2
KVLEDTGMPMDDDQY

EFCAB6

661

Q5THR3
PEEYEMQMQKLNKDF

FSIP1

206

Q8NA03
MSNPRSLEEEKYDMS

CASP14

1

P31944
TDEEMQYDMAKSGQE

RNASE11

31

Q8TAA1
MNNEYIVPMTEETKS

RYR2

1721

Q92736
VKQMPFTEMSEENIT

MSH2

891

P43246
TPEQISMDLKNELMY

DHX9

356

Q08211
KDDESEVQIPMMYQQ

SERPINI1

206

Q99574
VTMMQVEEKPDVTYS

PSMC2

161

P35998
MKSTKDYPDEVINFM

SEMA3F

421

Q13275
IYMEPEKQVMSRSSD

LARS1

506

Q9P2J5
KEFMNDPYIVITAME

TDRD12

626

Q587J7
KQVQPTMSQFEMDTY

NBEAL2

1716

Q6ZNJ1
DVYDDVETIPMKNME

PROM1

826

O43490
MDSDMDYERPNVETI

RHOBTB2

1

Q9BYZ6
KNFPMDMSDDYETQQ

SCG2

141

P13521
PDQYQEDASDMKDMS

SIKE1

51

Q9BRV8
NTPMQLYSDDNIMET

PDLIM3

191

Q53GG5
KMLEIYEPVSDSQMV

ICAM2

211

P13598
EAMKDMDSDQQYEKP

AKAP6

41

Q13023
FTISTLMDPEEMKDQ

CLEC20A

356

Q6ZU45
MERIQNPEYSTTMDV

TRPC1

146

P48995
MEEPQMALYLQQAKE

TRIM54

271

Q9BYV2
EELELDPMAMTQKYE

SF3B2

831

Q13435
DPMAMTQKYEEHVRE

SF3B2

836

Q13435
EDSFQQIMNMKPYDL

WWP2

526

O00308
TMKLAVMQAYDPEIN

TRIM13

206

O60858
EQRPVQMMYQEATFK

SERPINB9

191

P50453
PKNEDEMMVAIFEYI

XRN2

71

Q9H0D6
MEEKTDQPSDSEMMY

ZDBF2

1486

Q9HCK1
VEPKTESYGDMNMEN

RXRG

246

P48443
PEKYMMNSVLENFTI

TEAD4

381

Q15561
SKPYLTVDQMMDFIN

PLCB1

236

Q9NQ66
AQETYTCPKMIEMEQ

RWDD2B

21

P57060
EKMVYMTVNDSQPED

ZFX

296

P17010
RMESQLENVETPMSY

ZKSCAN3

466

Q9BRR0
SDPEMTEEEKEYQMM

PNISR

321

Q8TF01
SMIEQDVKRTFPEMQ

TBC1D5

161

Q92609
MTQIVIMLYEDPNKD

PPIP5K2

866

O43314
DMEKLDEMEFNPVQQ

WBP11

56

Q9Y2W2
MSQYTEKEPAAMDQE

PJA2

1

O43164
YSVKEQEEMLLMSSP

KCNJ3

356

P48549
SENMMIPDFKQQISE

MYO5C

1206

Q9NQX4
EKMLYEEETPKSQEM

PPP1R12B

336

O60237