Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	SUMO ligase activity	RGPD2 RANBP2 ZNF451	1.54e-05	20	49	3	GO:0061665
GeneOntologyMolecularFunction	SUMO transferase activity	RGPD2 RANBP2 ZNF451	9.37e-05	36	49	3	GO:0019789
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	SCRT2 ZNF16 ZNF142 ZFAT FEZF2 ZNF655 ZNF451 ZNF254 ZFHX2 ZNF723 ZNF319 ZNF304	1.18e-04	1412	49	12	GO:0000981
GeneOntologyMolecularFunction	Fc-gamma receptor I complex binding	IGHG1 IGHG4	1.23e-04	7	49	2	GO:0034988
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	SCRT2 ZNF16 ZNF142 ZFAT FEZF2 ZNF655 ZNF254 ZFHX2 ZNF362 ZNF723 ZNF319 ZNF304	1.61e-04	1459	49	12	GO:0000977
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	SCRT2 ZNF16 ZFAT FEZF2 ZNF655 ZNF254 ZFHX2 ZNF362 ZNF723 ZNF319 ZNF304	1.70e-04	1244	49	11	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	SCRT2 ZNF16 ZFAT FEZF2 ZNF655 ZNF254 ZFHX2 ZNF362 ZNF723 ZNF319 ZNF304	2.06e-04	1271	49	11	GO:0000987
GeneOntologyMolecularFunction	ubiquitin-like protein peptidase activity	USP34 SENP1 USP42 DESI2	3.54e-04	137	49	4	GO:0019783
GeneOntologyMolecularFunction	immunoglobulin receptor binding	IGHG1 IGHG4	1.20e-03	21	49	2	GO:0034987
GeneOntologyMolecularFunction	cysteine-type peptidase activity	USP34 SENP1 USP42 DESI2	1.25e-03	192	49	4	GO:0008234
GeneOntologyMolecularFunction	cysteine-type deubiquitinase activity	USP34 USP42 DESI2	2.76e-03	114	49	3	GO:0004843
GeneOntologyMolecularFunction	ubiquitin-like protein ligase activity	RGPD2 RANBP2 ZNF451 UBR3 MIB2	2.85e-03	398	49	5	GO:0061659
GeneOntologyMolecularFunction	deubiquitinase activity	USP34 USP42 DESI2	3.50e-03	124	49	3	GO:0101005
GeneOntologyBiologicalProcess	positive regulation of type I hypersensitivity	IGHG1 IGHG4	1.47e-04	8	48	2	GO:0001812
GeneOntologyBiologicalProcess	positive regulation of glucokinase activity	RGPD2 RANBP2	1.89e-04	9	48	2	GO:0033133
GeneOntologyBiologicalProcess	regulation of type I hypersensitivity	IGHG1 IGHG4	1.89e-04	9	48	2	GO:0001810
GeneOntologyBiologicalProcess	glomerular epithelial cell development	AMPD2 LAMB2	2.36e-04	10	48	2	GO:0072310
GeneOntologyBiologicalProcess	positive regulation of type II hypersensitivity	IGHG1 IGHG4	2.36e-04	10	48	2	GO:0002894
GeneOntologyBiologicalProcess	positive regulation of type IIa hypersensitivity	IGHG1 IGHG4	2.36e-04	10	48	2	GO:0001798
GeneOntologyBiologicalProcess	positive regulation of hexokinase activity	RGPD2 RANBP2	2.36e-04	10	48	2	GO:1903301
GeneOntologyBiologicalProcess	podocyte development	AMPD2 LAMB2	2.36e-04	10	48	2	GO:0072015
GeneOntologyBiologicalProcess	type I hypersensitivity	IGHG1 IGHG4	2.36e-04	10	48	2	GO:0016068
GeneOntologyBiologicalProcess	regulation of type II hypersensitivity	IGHG1 IGHG4	2.88e-04	11	48	2	GO:0002892
GeneOntologyBiologicalProcess	regulation of type IIa hypersensitivity	IGHG1 IGHG4	2.88e-04	11	48	2	GO:0001796
GeneOntologyBiologicalProcess	protein modification by small protein removal	USP34 SENP1 USP42 DESI2	3.49e-04	144	48	4	GO:0070646
GeneOntologyBiologicalProcess	regulation of glucokinase activity	RGPD2 RANBP2	4.07e-04	13	48	2	GO:0033131
GeneOntologyBiologicalProcess	antibody-dependent cellular cytotoxicity	IGHG1 IGHG4	4.07e-04	13	48	2	GO:0001788
GeneOntologyBiologicalProcess	regulation of hexokinase activity	RGPD2 RANBP2	4.74e-04	14	48	2	GO:1903299
GeneOntologyBiologicalProcess	positive regulation of hypersensitivity	IGHG1 IGHG4	5.46e-04	15	48	2	GO:0002885
GeneOntologyBiologicalProcess	type IIa hypersensitivity	IGHG1 IGHG4	5.46e-04	15	48	2	GO:0001794
GeneOntologyBiologicalProcess	type II hypersensitivity	IGHG1 IGHG4	5.46e-04	15	48	2	GO:0002445
GeneOntologyBiologicalProcess	protein sumoylation	RANBP2 SENP1 ZNF451	6.05e-04	71	48	3	GO:0016925
GeneOntologyBiologicalProcess	positive regulation of acute inflammatory response to antigenic stimulus	IGHG1 IGHG4	7.05e-04	17	48	2	GO:0002866
GeneOntologyCellularComponent	cytoplasmic periphery of the nuclear pore complex	RGPD2 RANBP2	1.37e-04	8	47	2	GO:1990723
GeneOntologyCellularComponent	nuclear pore cytoplasmic filaments	RGPD2 RANBP2	2.20e-04	10	47	2	GO:0044614
GeneOntologyCellularComponent	annulate lamellae	RGPD2 RANBP2	4.43e-04	14	47	2	GO:0005642
GeneOntologyCellularComponent	IgG immunoglobulin complex	IGHG1 IGHG4	4.43e-04	14	47	2	GO:0071735
GeneOntologyCellularComponent	immunoglobulin complex, circulating	IGHG1 IGHG4	6.59e-04	17	47	2	GO:0042571
GeneOntologyCellularComponent	nuclear pore nuclear basket	RGPD2 RANBP2	7.40e-04	18	47	2	GO:0044615
GeneOntologyCellularComponent	nuclear inclusion body	RGPD2 RANBP2	9.16e-04	20	47	2	GO:0042405
GeneOntologyCellularComponent	SUMO ligase complex	RGPD2 RANBP2	1.01e-03	21	47	2	GO:0106068
GeneOntologyCellularComponent	lamellipodium membrane	FAP DOCK8	1.11e-03	22	47	2	GO:0031258
MousePheno	abnormal morula morphology	RGPD2 RANBP2 ZNF622	3.00e-05	26	33	3	MP:0012058
MousePheno	absent memory B cells	IGHG1 IGHG4	3.23e-05	4	33	2	MP:0008094
MousePheno	failure of blastocyst formation	RGPD2 RANBP2 ZNF622	5.15e-05	31	33	3	MP:0012129
MousePheno	abnormal blastocyst formation	RGPD2 RANBP2 ZNF622	1.03e-04	39	33	3	MP:0012128
MousePheno	decreased memory B cell number	IGHG1 IGHG4	1.93e-04	9	33	2	MP:0008729
MousePheno	abnormal germinal center B cell number	DOCK8 IGHG1 IGHG4	2.89e-04	55	33	3	MP:0013680
MousePheno	abnormal germinal center B cell morphology	DOCK8 IGHG1 IGHG4	2.89e-04	55	33	3	MP:0008176
MousePheno	decreased IgG2c level	IGHG1 IGHG4	2.93e-04	11	33	2	MP:0008897
MousePheno	abnormal memory B cell number	IGHG1 IGHG4	2.93e-04	11	33	2	MP:0008093
MousePheno	abnormal memory B cell morphology	IGHG1 IGHG4	4.83e-04	14	33	2	MP:0002440
MousePheno	abnormal plasma cell differentiation	IGHG1 IGHG4	5.57e-04	15	33	2	MP:0008099
MousePheno	elevated level of mitotic sister chromatid exchange	RGPD2 RANBP2	6.35e-04	16	33	2	MP:0003701
MousePheno	enhanced humoral immune response	IGHG1 IGHG4	7.19e-04	17	33	2	MP:0020155
MousePheno	decreased immunoglobulin level	DCLRE1C DOCK8 IGHG1 IGHG4 IL21R	7.95e-04	315	33	5	MP:0002460
Domain	Znf_C2H2-like	ZNF462 SCRT2 ZNF16 ZNF142 ZFAT FEZF2 ZNF655 ZNF451 ZNF254 ZFHX2 ZNF622 ZNF362 ZNF319 ZNF304	3.92e-09	796	46	14	IPR015880
Domain	Znf_C2H2	ZNF462 SCRT2 ZNF16 ZNF142 ZFAT FEZF2 ZNF655 ZNF451 ZNF254 ZFHX2 ZNF622 ZNF362 ZNF319 ZNF304	4.53e-09	805	46	14	IPR007087
Domain	ZnF_C2H2	ZNF462 SCRT2 ZNF16 ZNF142 ZFAT FEZF2 ZNF655 ZNF451 ZNF254 ZFHX2 ZNF622 ZNF362 ZNF319 ZNF304	4.75e-09	808	46	14	SM00355
Domain	zf-C2H2	ZNF462 SCRT2 ZNF16 ZNF142 ZFAT FEZF2 ZNF655 ZNF451 ZNF254 ZFHX2 ZNF362 ZNF319 ZNF304	7.42e-09	693	46	13	PF00096
Domain	ZINC_FINGER_C2H2_2	ZNF462 SCRT2 ZNF16 ZNF142 ZFAT FEZF2 ZNF655 ZNF451 ZNF254 ZFHX2 ZNF362 ZNF319 ZNF304	2.80e-08	775	46	13	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF462 SCRT2 ZNF16 ZNF142 ZFAT FEZF2 ZNF655 ZNF451 ZNF254 ZFHX2 ZNF362 ZNF319 ZNF304	2.89e-08	777	46	13	PS00028
Domain	-	ZNF462 SCRT2 ZNF16 ZNF142 ZFAT FEZF2 ZNF655 ZNF254 ZFHX2 ZNF362 ZNF319 ZNF304	6.05e-08	679	46	12	3.30.160.60
Domain	Znf_C2H2/integrase_DNA-bd	ZNF462 SCRT2 ZNF16 ZNF142 ZFAT FEZF2 ZNF655 ZNF254 ZFHX2 ZNF362 ZNF319 ZNF304	7.68e-08	694	46	12	IPR013087
Domain	C1-set	IGHG1 IGHG4 MICA	3.18e-04	54	46	3	PF07654
Domain	IGc1	IGHG1 IGHG4 MICA	3.54e-04	56	46	3	SM00407
Domain	Ran_BP1	RGPD2 RANBP2	3.86e-04	12	46	2	PF00638
Domain	RANBD1	RGPD2 RANBP2	3.86e-04	12	46	2	PS50196
Domain	Ig_C1-set	IGHG1 IGHG4 MICA	3.92e-04	58	46	3	IPR003597
Domain	RanBD	RGPD2 RANBP2	4.55e-04	13	46	2	SM00160
Domain	Ran_bind_dom	RGPD2 RANBP2	4.55e-04	13	46	2	IPR000156
Domain	ZnF_U1	ZFHX2 ZNF622	2.31e-03	29	46	2	SM00451
Domain	Znf_U1	ZFHX2 ZNF622	2.31e-03	29	46	2	IPR003604
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	ZNF462 USP34 ZNF16 RANBP2 SENP1 ZNF142 USP42 ZNF655 ZNF451 LAMB2 ZNF362 ZNF319	7.85e-08	1203	49	12	29180619
Pubmed	The Transcription Factor AP4 Mediates Resolution of Chronic Viral Infection through Amplification of Germinal Center B Cell Responses.	IGHG1 IGHG4 IL21R	4.30e-07	11	49	3	27566940
Pubmed	Nucleotide sequences of gene segments encoding membrane domains of immunoglobulin gamma chains.	IGHG1 IGHG4	1.16e-05	4	49	2	6283537
Pubmed	Distinction of the memory B cell response to cognate antigen versus bystander inflammatory signals.	IGHG1 IGHG4	1.16e-05	4	49	2	19703988
Pubmed	Somatic mutation in genes for the variable portion of the immunoglobulin heavy chain.	IGHG1 IGHG4	1.16e-05	4	49	2	6801765
Pubmed	Sequence analysis of cloned cDNA encoding part of an immunoglobulin heavy chain.	IGHG1 IGHG4	1.16e-05	4	49	2	113776
Pubmed	Highly specific anti-estradiol antibodies: structural characterisation and binding diversity.	IGHG1 IGHG4	1.16e-05	4	49	2	11812141
Pubmed	Multiple amino acid substitutions between murine gamma 2a heavy chain Fc regions of Ig1a and Ig1b allotypic forms.	IGHG1 IGHG4	1.16e-05	4	49	2	6794027
Pubmed	Sequences near the 3' secretion-specific polyadenylation site influence levels of secretion-specific and membrane-specific IgG2b mRNA in myeloma cells.	IGHG1 IGHG4	1.16e-05	4	49	2	2878362
Pubmed	IgG1 deficiency exacerbates experimental autoimmune myasthenia gravis in BALB/c mice.	IGHG1 IGHG4	1.16e-05	4	49	2	25867470
Pubmed	Sequence of the gamma 2b membrane 3' untranslated region: polya site determination and comparison to the gamma 2a membrane 3' untranslated region.	IGHG1 IGHG4	1.16e-05	4	49	2	1542303
Pubmed	Switch of CD4+ T cell differentiation from Th2 to Th1 by treatment with cathepsin B inhibitor in experimental leishmaniasis.	IGHG1 IGHG4	1.16e-05	4	49	2	9725203
Pubmed	Immunoglobulin diversity: analysis of the germ-line VH gene repertoire of the murine anti-GAT response.	IGHG1 IGHG4	1.16e-05	4	49	2	6306571
Pubmed	Nucleotide sequences of all the gamma gene loci of murine immunoglobulin heavy chains.	IGHG1 IGHG4	1.16e-05	4	49	2	9126488
Pubmed	Rearrangement of immunoglobulin gamma 1-chain gene and mechanism for heavy-chain class switch.	IGHG1 IGHG4	1.16e-05	4	49	2	6767246
Pubmed	Determination of the interface of a large protein complex by transferred cross-saturation measurements.	IGHG1 IGHG4	1.16e-05	4	49	2	12051834
Pubmed	Further evidence that BALB/c and C57BL/6 gamma 2a genes originate from two distinct isotypes.	IGHG1 IGHG4	1.16e-05	4	49	2	2510996
Pubmed	Spontaneous deletions in Ig heavy chain genes: flanking sequences influence splice site selection.	IGHG1 IGHG4	1.16e-05	4	49	2	1754385
Pubmed	Sialic acid residues are essential for the anaphylactic activity of murine IgG1 antibodies.	IGHG1 IGHG4	1.16e-05	4	49	2	19050247
Pubmed	The molecular and biochemical characterization of mutant monoclonal antibodies with increased antigen binding.	IGHG1 IGHG4	1.16e-05	4	49	2	1672339
Pubmed	The gamma 1 heavy chain gene includes all of the cis-acting elements necessary for expression of properly regulated germ-line transcripts.	IGHG1 IGHG4	1.16e-05	4	49	2	8683112
Pubmed	The IL-4 induced increase in the frequency of resting murine splenic B cells expressing germline Ig heavy chain gamma 1 transcripts correlates with subsequent switching to IgG1.	IGHG1 IGHG4	1.16e-05	4	49	2	8452816
Pubmed	Genes for immunoglobulin heavy chain and serum prealbumin protein are linked in mouse.	IGHG1 IGHG4	1.16e-05	4	49	2	807855
Pubmed	Identification of a gene locus for gamma-G-1 immunoglobulin H chains and its linkage to the H chain chromosome region in the mouse.	IGHG1 IGHG4	1.16e-05	4	49	2	4166666
Pubmed	Multiple B-cell epitope vaccine induces a Staphylococcus enterotoxin B-specific IgG1 protective response against MRSA infection.	IGHG1 IGHG4	1.16e-05	4	49	2	26201558
Pubmed	An autoimmune disease variant of IgG1 modulates B cell activation and differentiation.	IGHG1 IGHG4	1.16e-05	4	49	2	30287618
Pubmed	Switch transcripts in immunoglobulin class switching.	IGHG1 IGHG4	1.16e-05	4	49	2	7892607
Pubmed	Determination of the primary structure of a mouse G2a immunoglobulin. Identification of the disulfide bridges.	IGHG1 IGHG4	1.16e-05	4	49	2	4565406
Pubmed	Recognition of a cell-surface oligosaccharide of pathogenic Salmonella by an antibody Fab fragment.	IGHG1 IGHG4	1.16e-05	4	49	2	1713710
Pubmed	Structure of the constant and 3' untranslated regions of the murine Balb/c gamma 2a heavy chain messenger RNA.	IGHG1 IGHG4	1.16e-05	4	49	2	6777755
Pubmed	The roles of gamma 1 heavy chain membrane expression and cytoplasmic tail in IgG1 responses.	IGHG1 IGHG4	1.16e-05	4	49	2	9103199
Pubmed	Molecular cloning of mouse immunoglobulin heavy chain messenger ribonucleic acids coding for mu, alpha, gamma 1, gamma 2a, and gamma 3 chains.	IGHG1 IGHG4	1.16e-05	4	49	2	6249338
Pubmed	mRNA for surface immunoglobulin gamma chains encodes a highly conserved transmembrane sequence and a 28-residue intracellular domain.	IGHG1 IGHG4	1.16e-05	4	49	2	6804950
Pubmed	Gene conversion and polymorphism: generation of mouse immunoglobulin gamma 2a chain alleles by differential gene conversion by gamma 2b chain gene.	IGHG1 IGHG4	1.16e-05	4	49	2	6297797
Pubmed	Integrin-dependent organization and bidirectional vesicular traffic at cytotoxic immune synapses.	IGHG1 IGHG4	1.16e-05	4	49	2	19592272
Pubmed	Evolution of immunoglobulin subclasses. Primary structure of a murine myeloma gamma1 chain.	IGHG1 IGHG4	1.16e-05	4	49	2	98524
Pubmed	IgG1 protects against renal disease in a mouse model of cryoglobulinaemia.	IGHG1 IGHG4	1.16e-05	4	49	2	25363774
Pubmed	Attenuation of Trypanosoma brucei is associated with reduced immunosuppression and concomitant production of Th2 lymphokines.	IGHG1 IGHG4	1.16e-05	4	49	2	10720538
Pubmed	Determination of the primary structure of a mouse IgG2a immunoglobulin:amino-acid sequence of the Fc fragment. Implications for the evolution of immunoglobulin structure and function.	IGHG1 IGHG4	1.16e-05	4	49	2	4831970
Pubmed	Nucleotide sequences of class-switch recombination region of the mouse immunoglobulin gamma 2b-chain gene.	IGHG1 IGHG4	1.16e-05	4	49	2	7439686
Pubmed	Mutational deglycosylation of the Fc portion of immunoglobulin G causes O-sulfation of tyrosine adjacently preceding the originally glycosylated site.	IGHG1 IGHG4	1.16e-05	4	49	2	20621099
Pubmed	Immunoglobulin heavy constant gamma 1 silencing decreases tonicity-responsive enhancer-binding protein expression to alleviate diabetic nephropathy.	IGHG1 IGHG4	1.16e-05	4	49	2	38268239
Pubmed	Elucidation of the enigmatic IgD class-switch recombination via germline deletion of the IgH 3' regulatory region.	IGHG1 IGHG4	1.16e-05	4	49	2	24752300
Pubmed	Variable-region-identical antibodies differing in isotype demonstrate differences in fine specificity and idiotype.	IGHG1 IGHG4	1.16e-05	4	49	2	15699144
Pubmed	Antibody epitopes on the neuraminidase of a recent H3N2 influenza virus (A/Memphis/31/98).	IGHG1 IGHG4	1.16e-05	4	49	2	12414967
Pubmed	On immunoglobulin heavy chain gene switching: two gamma 2b genes are rearranged via switch sequences in MPC-11 cells but only one is expressed.	IGHG1 IGHG4	1.16e-05	4	49	2	6278424
Pubmed	An Asia-specific variant of human IgG1 represses colorectal tumorigenesis by shaping the tumor microenvironment.	IGHG1 IGHG4	1.16e-05	4	49	2	35133976
Pubmed	Gene segments encoding transmembrane carboxyl termini of immunoglobulin gamma chains.	IGHG1 IGHG4	1.16e-05	4	49	2	6799207
Pubmed	Restriction fragment length polymorphism and evolution of the mouse immunoglobulin constant region gamma loci.	IGHG1 IGHG4	1.16e-05	4	49	2	8099342
Pubmed	Comparison of mouse immunoglobulin gamma 2a and gamma 2b chain genes suggests that exons can be exchanged between genes in a multigenic family.	IGHG1 IGHG4	1.16e-05	4	49	2	6787604
Pubmed	Shutdown of class switch recombination by deletion of a switch region control element.	IGHG1 IGHG4	1.16e-05	4	49	2	8438159
Pubmed	Passive anaphylaxis in mice with gamma-G antibodies. V. Competitive effects of different immunoglobulins and inhibition of reactions with antiglobulin sera.	IGHG1 IGHG4	1.16e-05	4	49	2	4098598
Pubmed	Sequence and polyadenylation site determination of the murine immunoglobulin gamma 2a membrane 3' untranslated region.	IGHG1 IGHG4	1.16e-05	4	49	2	2513486
Pubmed	Mouse immunoglobulin genes: a bacterial plasmid containing the entire coding sequence for a pre-gamma 2a heavy chain.	IGHG1 IGHG4	1.16e-05	4	49	2	6253932
Pubmed	Increased number of T cells and exacerbated inflammatory pathophysiology in a human IgG4 knock-in MRL/lpr mouse model.	IGHG1 IGHG4	1.16e-05	4	49	2	36763580
Pubmed	Ubiquitination of IgG1 cytoplasmic tail modulates B-cell signalling and activation.	IGHG1 IGHG4	1.16e-05	4	49	2	32006024
Pubmed	Immunoglobulin gamma 1 heavy chain gene: structural gene sequences cloned in a bacterial plasmid.	IGHG1 IGHG4	1.16e-05	4	49	2	6769752
Pubmed	Strong antigenic selection shaping the immunoglobulin heavy chain repertoire of B-1a lymphocytes in lambda 2(315) transgenic mice.	IGHG1 IGHG4	1.16e-05	4	49	2	12209645
Pubmed	Independent immunoglobulin class-switch events occurring in a single myeloma cell line.	IGHG1 IGHG4	1.16e-05	4	49	2	3921826
Pubmed	Mouse immunoglobulin allotypes: post-duplication divergence of gamma 2a and gamma 2b chain genes.	IGHG1 IGHG4	1.16e-05	4	49	2	6803173
Pubmed	Sequence of the cloned gene for the constant region of murine gamma 2b immunoglobulin heavy chain.	IGHG1 IGHG4	1.16e-05	4	49	2	117549
Pubmed	Cloning immunoglobulin gamma 2b chain gene of mouse: characterization and partial sequence determination.	IGHG1 IGHG4	1.16e-05	4	49	2	116231
Pubmed	The complete nucleotide sequence of mouse immunoglobin gamma 2a gene and evolution of heavy chain genes: further evidence for intervening sequence-mediated domain transfer.	IGHG1 IGHG4	1.16e-05	4	49	2	6262729
Pubmed	Pro-inflammatory pattern of IgG1 Fc glycosylation in multiple sclerosis cerebrospinal fluid.	IGHG1 IGHG4	1.16e-05	4	49	2	26683050
Pubmed	Multiple differences between the nucleic acid sequences of the IgG2aa and IgG2ab alleles of the mouse.	IGHG1 IGHG4	1.16e-05	4	49	2	6170065
Pubmed	Highly reduced binding to high and low affinity mouse Fc gamma receptors by L234A/L235A and N297A Fc mutations engineered into mouse IgG2a.	IGHG1 IGHG4	1.16e-05	4	49	2	25451975
Pubmed	Linkage of the four gamma subclass heavy chain genes.	IGHG1 IGHG4	1.16e-05	4	49	2	6264445
Pubmed	Complete nucleotide sequence of immunoglobulin gamma2b chain gene cloned from newborn nouse DNA.	IGHG1 IGHG4	1.16e-05	4	49	2	6766534
Pubmed	Preneoplastic somatic mutations including MYD88L265P in lymphoplasmacytic lymphoma.	IGHG1 IGHG4	1.94e-05	5	49	2	35044826
Pubmed	FcgammaRIII (CD16)-deficient mice show IgG isotype-dependent protection to experimental autoimmune hemolytic anemia.	IGHG1 IGHG4	1.94e-05	5	49	2	9834201
Pubmed	IgG1 cytoplasmic tail is essential for cell surface expression in Igβ down-regulated cells.	IGHG1 IGHG4	1.94e-05	5	49	2	24548411
Pubmed	Exon shuffling generates an immunoglobulin heavy chain gene.	IGHG1 IGHG4	1.94e-05	5	49	2	6769120
Pubmed	Chromosomal location of the structural gene cluster encoding murine immunoglobulin heavy chains.	IGHG1 IGHG4	1.94e-05	5	49	2	6770027
Pubmed	The synthesis and processing of the messenger RNAs specifying heavy and light chain immunoglobulins in MPC-11 cells.	IGHG1 IGHG4	1.94e-05	5	49	2	103631
Pubmed	Sequential class switching is required for the generation of high affinity IgE antibodies.	IGHG1 IGHG4	1.94e-05	5	49	2	22249450
Pubmed	CCAAT/enhancer binding protein β Induces Post-Switched B Cells to Produce Blimp1 and Differentiate into Plasma Cells.	IGHG1 IGHG4	1.94e-05	5	49	2	33163250
Pubmed	Protein arginine methyltransferase 1 regulates B cell fate after positive selection in the germinal center in mice.	IGHG1 IGHG4	1.94e-05	5	49	2	37310381
Pubmed	The FOXO1 Transcription Factor Instructs the Germinal Center Dark Zone Program.	IGHG1 IGHG4	1.94e-05	5	49	2	26620759
Pubmed	Expression of NrasQ61R and MYC transgene in germinal center B cells induces a highly malignant multiple myeloma in mice.	IGHG1 IGHG4	1.94e-05	5	49	2	32640012
Pubmed	Mouse models of human multiple myeloma subgroups.	IGHG1 IGHG4	1.94e-05	5	49	2	36853944
Pubmed	Repetitive sequences in class-switch recombination regions of immunoglobulin heavy chain genes.	IGHG1 IGHG4	1.94e-05	5	49	2	6781756
Pubmed	Cre-loxP-mediated gene replacement: a mouse strain producing humanized antibodies.	IGHG1 IGHG4	1.94e-05	5	49	2	7704573
Pubmed	YY1 Is Required for Germinal Center B Cell Development.	IGHG1 IGHG4	1.94e-05	5	49	2	27167731
Pubmed	Murine IgG1 complexes trigger immune effector functions predominantly via Fc gamma RIII (CD16).	IGHG1 IGHG4	1.94e-05	5	49	2	9743367
Pubmed	Channel catfish soluble FcmuR binds conserved linear epitopes present on Cmu3 and Cmu4.	IGHG1 IGHG4	1.94e-05	5	49	2	20031218
Pubmed	IgE knock-in mice suggest a role for high levels of IgE in basophil-mediated active systemic anaphylaxis.	IGHG1 IGHG4	1.94e-05	5	49	2	23423996
Pubmed	Human and murine immunoglobulin expression vector cassettes.	IGHG1 IGHG4	1.94e-05	5	49	2	11257305
Pubmed	Serine-threonine kinase ROCK2 regulates germinal center B cell positioning and cholesterol biosynthesis.	IGHG1 IGHG4	1.94e-05	5	49	2	32229726
Pubmed	Molecular and cellular basis of the retrovirus resistance in I/LnJ mice.	IGHG1 IGHG4	1.94e-05	5	49	2	16301663
Pubmed	Brg1 Supports B Cell Proliferation and Germinal Center Formation Through Enhancer Activation.	IGHG1 IGHG4	1.94e-05	5	49	2	34539636
Pubmed	The disulphide bridges of a mouse immunoglobulin G1 protein.	IGHG1 IGHG4	1.94e-05	5	49	2	5073237
Pubmed	Rate of replication of the murine immunoglobulin heavy-chain locus: evidence that the region is part of a single replicon.	IGHG1 IGHG4	1.94e-05	5	49	2	3031474
Pubmed	A novel allele for inducible Cre expression in germinal center B cells.	IGHG1 IGHG4	1.94e-05	5	49	2	30359469
Pubmed	Functional humanization of immunoglobulin heavy constant gamma 1 Fc domain human FCGRT transgenic mice.	IGHG1 IGHG4	1.94e-05	5	49	2	33025844
Pubmed	Targeted gene disruption reveals a role for natural secretory IgM in the maturation of the primary immune response.	IGHG1 IGHG4	1.94e-05	5	49	2	9707605
Pubmed	Evidence that High-Affinity IgE Can Develop in the Germinal Center in the Absence of an IgG1-Switched Intermediate.	IGHG1 IGHG4	1.94e-05	5	49	2	36779803
Pubmed	Organization, structure, and assembly of immunoglobulin heavy chain diversity DNA segments.	IGHG1 IGHG4	1.94e-05	5	49	2	6798155
Pubmed	Id3 Orchestrates Germinal Center B Cell Development.	IGHG1 IGHG4	2.91e-05	6	49	2	27457619
Pubmed	Preferential production of IgG1, IL-4 and IL-10 in MuSK-immunized mice.	IGHG1 IGHG4	2.91e-05	6	49	2	24589747
Pubmed	Notch2 controls developmental fate choices between germinal center and marginal zone B cells upon immunization.	IGHG1 IGHG4	2.91e-05	6	49	2	38438375
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF462 SCRT2 ZNF16 ZNF142 ZFAT FEZF2 ZNF655 ZNF451 ZNF254 ZFHX2 ZNF362 ZNF319 ZNF304	3.61e-10	718	35	13	28
Coexpression	NAKAYA_B_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_UP	RANBP2 IGHG1 ZNF451 IL21R PDE5A DESI2 LRRFIP2	4.48e-06	367	48	7	M41159
Coexpression	GSE45365_WT_VS_IFNAR_KO_CD11B_DC_MCMV_INFECTION_DN	ZNF462 FAP CENPF OTOGL KHDC1	2.59e-05	191	48	5	M9977
Disease	common variable immunodeficiency (is_implicated_in)	DCLRE1C IL21R	1.49e-05	4	47	2	DOID:12177 (is_implicated_in)
Disease	Combined immunodeficiency	DCLRE1C DOCK8 IL21R	3.87e-05	41	47	3	C0494261
Disease	amyloid plaque accumulation rate	UBR3 DESI2	1.62e-04	12	47	2	EFO_0007646
Disease	Omenn Syndrome	DCLRE1C IL21R	4.17e-04	19	47	2	C2700553
Disease	Severe Combined Immunodeficiency	DCLRE1C IL21R	4.63e-04	20	47	2	C0085110
Disease	response to antineoplastic agent	CENPF ZNF254 MICA	5.34e-04	99	47	3	GO_0097327
Disease	diacylglycerol 34:1 measurement	LPL ZNF254	6.70e-04	24	47	2	EFO_0010352
Disease	diacylglycerol 34:2 measurement	CACNA2D4 LPL	7.28e-04	25	47	2	EFO_0010353
Disease	cholesterol to total lipids in small LDL percentage	IGHG1 LPL	8.50e-04	27	47	2	EFO_0022241
Disease	serum IgA measurement	MTMR3 MICA	1.12e-03	31	47	2	EFO_0004912
Disease	triacylglycerol 54:3 measurement	CACNA2D4 LPL	1.12e-03	31	47	2	EFO_0010421
Disease	reticulocyte measurement	USP34 SENP1 USP42 LPL MTMR3 PDE5A MICA	1.31e-03	1053	47	7	EFO_0010700
Disease	triacylglycerol 52:5 measurement	CACNA2D4 LPL	1.43e-03	35	47	2	EFO_0010417
Disease	triacylglycerol 56:8 measurement	CACNA2D4 LPL	1.51e-03	36	47	2	EFO_0010435
Disease	type 1 diabetes mellitus (implicated_via_orthology)	SENP1 DOCK8	1.77e-03	39	47	2	DOID:9744 (implicated_via_orthology)
Disease	triglycerides to total lipids in medium LDL percentage	LPL MICA	2.90e-03	50	47	2	EFO_0022334
Disease	cholesteryl esters to total lipids in IDL percentage	LPL MICA	2.90e-03	50	47	2	EFO_0022247
Disease	triglycerides to total lipids in large LDL percentage	LPL MICA	3.01e-03	51	47	2	EFO_0022331

Protein segments in the cluster

Peptide	Gene	Start	Entry
DTHIHASSCMNQKHL	AMPD2	416	Q01433
YHLMHKNCNHFSSAL	DESI2	101	Q9BSY9
HLQLKEKCNSHHSSY	RANBP2	496	P49792
TKTHYHAMHADCLQE	MICA	176	Q29983
TCHFNHSSKTFMVIH	LPL	66	P06858
YCHSIMEHHHFDQCL	PDE5A	676	O76074
GHTHSCHFDMAVYLA	LAMB2	351	P55268
LSSLNHSYSHSHGMK	LRRFIP2	121	Q9Y608
ARAYFLSHCHKDHMK	DCLRE1C	26	Q96SD1
DLCHQVLHHCSSSMD	DOCK8	1506	Q8NF50
SEHKILHDQHCQMSS	CENPF	1416	P49454
DYQAMCKPSSHHHSA	CACNA2D4	936	Q7Z3S7
HMFCCVGSQDSYHHA	KHDC1	156	Q4VXA5
AHNATHATYTCHMDV	IL21R	71	Q9HBE5
HATYTCHMDVFHFMA	IL21R	76	Q9HBE5
FSCSVMHEALHNHYT	IGHG1	306	P01857
MHEALHNHYTQKSLS	IGHG1	311	P01857
SVMHEALHNHYTQKS	IGHG4	306	P01861
FHMHTHNDKKPFTCA	FEZF2	406	Q8TBJ5
AMSCSSAHLHSRNLH	MTMR3	976	Q13615
QKGMLYHHCSSFCLH	OTOGL	746	Q3ZCN5
TQCYMHNKHELAHAF	MIB2	116	Q96AX9
LYKTHVISHSYCEHM	OR52M1	171	Q8NGK5
NCYHSATLCMHANTH	ERVW-1	71	Q9UQF0
RAHMQTHSAFKHYRC	SCRT2	256	Q9NQ03
HLQLKEKCNSHHSSY	RGPD2	496	P0DJD1
KMSLCHAHHASKVNQ	SPATA31A6	1216	Q5VVP1
KSNHHCHVSAYEKSF	SENP1	136	Q9P0U3
HLGMSCHSKTDFCHH	STS	136	P08842
THLHLAEDCMKHYQG	STXBP1	346	P61764
SLHEDMNCFSHSAAH	ABTB2	646	Q8N961
MDHEYPCHHITSHCT	CLUHP3	81	Q96NS8
TNHLYTHMTHFLKQC	FAP	741	Q12884
EECSKHMSGKNHFHQ	ZNF451	266	Q9Y4E5
MSLASHKFHRYSCAH	ZNF451	626	Q9Y4E5
ANYMLSHEHSKTCHA	USP42	136	Q9H9J4
SHEHSKTCHAEGFCM	USP42	141	Q9H9J4
AHMNRHSTEKTHLCD	ZFAT	926	Q9P243
HMREKHPESNSHCSY	ZFHX2	471	Q9C0A1
SFCMLSHLTKHERNH	ZNF723	181	P0DPD5
HSHHSQMVASSACLS	TRABD2A	471	Q86V40
HDASEEYKHRMHNLC	TMEM222	126	Q9H0R3
HMYAHSGEHHLFRCN	ZNF319	276	Q9P2F9
AFSQTSCLIQHHKMH	ZNF655	416	Q8N720
CGHTLHIDCHKSYME	UBR3	1326	Q6ZT12
SAHAIKHAKAYCCSM	ZNF362	361	Q5T0B9
HRSHMSEKAYQCSEC	ZNF16	256	P17020
FSTAELLCMHYTDHH	ZNF462	1856	Q96JM2
FCSHHSSSLMKNVAH	ZNF622	256	Q969S3
MHQKFHTGKRHYTCS	ZNF304	296	Q9HCX3
EAMEAHHKSHYAFHC	ZNF142	331	P52746
NTLHMMYHEATACHV	USP34	2976	Q70CQ2
FCMLSHKTQHKSIYH	ZNF254	191	O75437