Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Pubmed	Capicua regulates the development of adult-born neurons in the hippocampus.	EMX1 CIC	3.66e-06	2	67	2	34083623
Pubmed	Region-Specific Disruption of Adenylate Cyclase Type 1 Gene Differentially Affects Somatosensorimotor Behaviors in Mice.	EMX1 ADCY1	3.66e-06	2	67	2	26023682
Pubmed	Region-Specific Disruption of Adenylate Cyclase Type 1 Gene Differentially Affects Somatosensorimotor Behaviors in Mice(1,2,3).	EMX1 ADCY1	3.66e-06	2	67	2	26464960
Pubmed	Essential roles of dopamine D4 receptors and the type 1 adenylyl cyclase in photic control of cyclic AMP in photoreceptor cells.	DRD4 ADCY1	3.66e-06	2	67	2	19166506
Pubmed	Dopamine D₄ receptor activation controls circadian timing of the adenylyl cyclase 1/cyclic AMP signaling system in mouse retina.	DRD4 ADCY1	3.66e-06	2	67	2	21676039
Pubmed	Ablation of the presynaptic organizer Bassoon in excitatory neurons retards dentate gyrus maturation and enhances learning performance.	BSN EMX1	3.66e-06	2	67	2	29915867
Pubmed	Cortical adenylyl cyclase 1 is required for thalamocortical synapse maturation and aspects of layer IV barrel development.	EMX1 ADCY1	1.10e-05	3	67	2	18524897
Pubmed	Dact1 is a postsynaptic protein required for dendrite, spine, and excitatory synapse development in the mouse forebrain.	DACT1 EMX1	1.10e-05	3	67	2	20335472
Pubmed	Inactivation of Capicua drives cancer metastasis.	MMP24 CIC	1.10e-05	3	67	2	27869830
Pubmed	Sustained generation of neurons destined for neocortex with oxidative metabolic upregulation upon filamin abrogation.	FLNA EMX1	1.10e-05	3	67	2	38989458
Pubmed	Identification of the SOX2 Interactome by BioID Reveals EP300 as a Mediator of SOX2-dependent Squamous Differentiation and Lung Squamous Cell Carcinoma Growth.	PRR12 ARID1B TCF20 CIC	2.06e-05	83	67	4	28794006
Pubmed	Circadian rhythm of contrast sensitivity is regulated by a dopamine-neuronal PAS-domain protein 2-adenylyl cyclase 1 signaling pathway in retinal ganglion cells.	DRD4 ADCY1	2.19e-05	4	67	2	24048828
Pubmed	MEK-ERK1/2-dependent FLNA overexpression promotes abnormal dendritic patterning in tuberous sclerosis independent of mTOR.	FLNA EMX1	2.19e-05	4	67	2	25277454
Pubmed	Thalamic adenylyl cyclase 1 is required for barrel formation in the somatosensory cortex.	EMX1 ADCY1	2.19e-05	4	67	2	25644422
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	PRR12 DACT1 FLNA ARHGEF40 ZNF628 ANKRD9 NUBPL CIC RYR1 CABLES1	4.83e-05	1105	67	10	35748872
Pubmed	A genome-wide scan maps a novel high myopia locus to 5p15.	TENT4A IRX1	5.46e-05	6	67	2	18421076
Pubmed	Ataxin-7 is a subunit of GCN5 histone acetyltransferase-containing complexes.	ATXN7 TAF10	5.46e-05	6	67	2	15115762
Pubmed	Differential roles of ARID1B in excitatory and inhibitory neural progenitors in the developing cortex.	ARID1B EMX1	1.02e-04	8	67	2	33594090
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	PRR12 HABP4 NOP14 GIPC2 ATXN7 CDKN2AIP CCT4 LSM11 TAF10 CIC PPP1R12C	1.27e-04	1497	67	11	31527615
Pubmed	The putative cancer stem cell marker USP22 is a subunit of the human SAGA complex required for activated transcription and cell-cycle progression.	ATXN7 TAF10	1.63e-04	10	67	2	18206973
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	PRR12 FLNA ARID1B NOP14 TCF20 CDKN2AIP CCT4 TAF10 CIC	2.58e-04	1103	67	9	34189442
Pubmed	Loss of BAF (mSWI/SNF) Complexes Causes Global Transcriptional and Chromatin State Changes in Forebrain Development.	ARID1B TFAP2E EMX1	2.74e-04	65	67	3	26655900
Pubmed	Biological insights from 108 schizophrenia-associated genetic loci.	PRR12 TCF20 ATXN7 DGKI PBX4	3.02e-04	303	67	5	25056061
Pubmed	LncRNAs-directed PTEN enzymatic switch governs epithelial-mesenchymal transition.	TCF24 PABPN1 EMX1 QSOX2	3.18e-04	168	67	4	30631154
Pubmed	Identification of a small TAF complex and its role in the assembly of TAF-containing complexes.	ATXN7 TAF10	3.28e-04	14	67	2	17375202
Pubmed	DYX1C1 is required for axonemal dynein assembly and ciliary motility.	CCT4 EMX1	4.31e-04	16	67	2	23872636
Pubmed	Cerebral Cortex Expression of Gli3 Is Required for Normal Development of the Lateral Olfactory Tract.	TFAP2E EMX1	5.48e-04	18	67	2	26509897
Pubmed	Prediction of the coding sequences of mouse homologues of FLJ genes: the complete nucleotide sequences of 110 mouse FLJ-homologous cDnas identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	FLNA ARHGEF40 SLC27A3	6.03e-04	85	67	3	15449545
Pubmed	Impact of cytosine methylation on DNA binding specificities of human transcription factors.	FOXD2 SCRT1 TFAP2E IRX1 EMX1 EVX2	6.34e-04	544	67	6	28473536
Pubmed	UV-damaged DNA-binding protein in the TFTC complex links DNA damage recognition to nucleosome acetylation.	ATXN7 TAF10	6.79e-04	20	67	2	11406595
Pubmed	Cytoplasmic ATXN7L3B Interferes with Nuclear Functions of the SAGA Deubiquitinase Module.	ATXN7 TAF10	6.79e-04	20	67	2	27601583
Pubmed	Function of TAF(II)-containing complex without TBP in transcription by RNA polymerase II.	ATXN7 TAF10	6.79e-04	20	67	2	9603525
Pubmed	Identification of TATA-binding protein-free TAFII-containing complex subunits suggests a role in nucleosome acetylation and signal transduction.	ATXN7 TAF10	6.79e-04	20	67	2	10373431
Pubmed	Loss of BAF Complex in Developing Cortex Perturbs Radial Neuronal Migration in a WNT Signaling-Dependent Manner.	ARID1B EMX1	6.79e-04	20	67	2	34220450
Pubmed	Characterization of the proteins of isolated human platelet alpha-granules. Evidence for a separate alpha-granule-pool of the glycoproteins IIb and IIIa.	FLNA HABP4	7.50e-04	21	67	2	6457647
Pubmed	HAND1 loss-of-function within the embryonic myocardium reveals survivable congenital cardiac defects and adult heart failure.	HCN4 ADCY1	8.24e-04	22	67	2	31286141
Pubmed	Disruption of the ATXN1-CIC complex causes a spectrum of neurobehavioral phenotypes in mice and humans.	EMX1 CIC	1.07e-03	25	67	2	28288114
Pubmed	AP2gamma regulates basal progenitor fate in a region- and layer-specific manner in the developing cortex.	TFAP2E EMX1	1.15e-03	26	67	2	19749747
Pubmed	Histone methylation mediated by NSD1 is required for the establishment and maintenance of neuronal identities.	EMX1 RYR1	1.24e-03	27	67	2	37995181
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	PRR12 FLNA TCF20 TET1 CIC	1.28e-03	418	67	5	34709266
Pubmed	Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies.	MMP24 ASTN2	1.34e-03	28	67	2	18839057
Pubmed	The human SPT20-containing SAGA complex plays a direct role in the regulation of endoplasmic reticulum stress-induced genes.	ATXN7 TAF10	1.34e-03	28	67	2	19114550
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	ARID1B TCF20 ATXN7 BSN CIC RYR1	1.44e-03	638	67	6	31182584
Pubmed	A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing.	ATXN7 TAF10	1.54e-03	30	67	2	18206972
Pubmed	Heritable Thoracic Aortic Disease Overview	FLNA HCN4	1.54e-03	30	67	2	20301299
Pubmed	Human transcription factor protein interaction networks.	PRR12 ARID1B NOP14 TCF20 PABPN1 ATXN7 CCT4 TAF10 CIC	1.63e-03	1429	67	9	35140242
Pubmed	DNA-binding specificities of human transcription factors.	FOXD2 SCRT1	1.64e-03	31	67	2	23332764
Pubmed	Characterization of the proteins released from activated platelets leads to localization of novel platelet proteins in human atherosclerotic lesions.	FLNA HABP4	1.64e-03	31	67	2	14630798
Pubmed	A census of human transcription factors: function, expression and evolution.	FOXD2 TFAP2E PBX4 IRX1 EMX1 CIC EVX2	1.80e-03	908	67	7	19274049
Pubmed	Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.	PRR12 ARID1B TCF20 CIC	1.81e-03	268	67	4	33640491
Pubmed	ZBTB18 inhibits SREBP-dependent lipid synthesis by halting CTBPs and LSD1 activity in glioblastoma.	FLNA CCT4	1.86e-03	33	67	2	36414381
Pubmed	The PcG protein hPc2 interacts with the N-terminus of histone demethylase JARID1B and acts as a transcriptional co-repressor.	ARID1B TMEM121B	1.86e-03	33	67	2	19336002
Pubmed	Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo.	ATXN7 TAF10	1.86e-03	33	67	2	11564863
Interaction	IRF4 interactions	PRR12 ARID1B GIPC2 TCF20 CIC	8.65e-06	85	66	5	int:IRF4
Cytoband	19q13.42	ZNF628 SHISA7 PPP1R12C	8.31e-04	125	67	3	19q13.42
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	PRR12 ZNF628 DEDD2 SHISA7 CIC RYR1 PPP1R12C	1.75e-03	1192	67	7	chr19q13
GeneFamily	Lysine acetyltransferases\|ATAC complex\|SAGA complex\|GCN5 related N-acetyltransferases	ATXN7 TAF10	8.41e-04	17	46	2	1059
GeneFamily	TALE class homeoboxes and pseudogenes	PBX4 IRX1	1.98e-03	26	46	2	526
Coexpression	MIKKELSEN_MCV6_HCP_WITH_H3K27ME3	LRRC75B DRD4 SCRT1 TFAP2E IRX1 BSN EMX1 SHISA7 EVX2	1.70e-06	438	67	9	M1954
Coexpression	MIKKELSEN_MCV6_HCP_WITH_H3K27ME3	LRRC75B DRD4 SCRT1 TFAP2E IRX1 BSN EMX1 SHISA7 EVX2	1.76e-06	440	67	9	MM832
ToppCell	facs-Brain_Non-Myeloid-Striatum_-18m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SCRT1 PDXP IRX1 BSN CADPS2 ADCY1	3.85e-07	187	67	6	ef3c85c01bc3da408ae288b6e3096ad888a12e63
ToppCell	facs-Brain_Non-Myeloid-Cerebellum_-18m-Neuronal-interneuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MMP24 PDXP ASTN2 BSN CADPS2 ADCY1	3.85e-07	187	67	6	1b2fdbfb1ce3f19795dfc4b1da5a94f4b057ec41
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal-Granular_Neuron_CB_Gabra6\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DACT1 SHC2 PDXP ASTN2 ADCY1	5.17e-06	166	67	5	ec7bd549bda5f18aca8aebce5ba479a81abbbeda
ToppCell	facs-Brain_Non-Myeloid-Striatum_-18m-Neuronal-interneuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SCRT1 PDXP IRX1 CADPS2 ADCY1	8.98e-06	186	67	5	a1ab273b01971d6a892912560d387685dd657179
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SCRT1 PDXP BSN CADPS2 ADCY1	9.70e-06	189	67	5	f57200c93d39c9bce1adba0a6a1c178c028dd86b
ToppCell	facs-Brain_Non-Myeloid-Striatum_-18m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SCRT1 PDXP BSN CADPS2 ADCY1	9.70e-06	189	67	5	3d838da870623a6a278ddc8e6cedca85d9877e50
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SCRT1 PDXP BSN CADPS2 ADCY1	1.07e-05	193	67	5	5fb7808dd971c1cc64c2bd4f8f1de646fb2d77f4
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW12-Mesenchymal-Unfolded_protein_responsible_cell\|GW12 / Sample Type, Dataset, Time_group, and Cell type.	EPM2A NOP14 ZNF628 PPP1R12C C2orf72	1.27e-05	200	67	5	6b7314c425f6b40f1301dd39cc02b0436e96a2ec
ToppCell	21-Trachea-Immune-Immune\|Trachea / Age, Tissue, Lineage and Cell class	AVEN HABP4 PDXP ADCY1	4.99e-05	134	67	4	4f0465324cc5b443ebadb68aef63be79b74f6ff9
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GIPC2 OTUD7A DGKI CHSY3	5.91e-05	140	67	4	7ca49bd7ba9381e75c10f888775df17e5d46804d
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GIPC2 OTUD7A DGKI CHSY3	5.91e-05	140	67	4	1a31bc33d5723b9bc528cc0047ca5f4c80531c7a
ToppCell	343B-Epithelial_cells-Epithelial-E_(AT2)\|343B / Donor, Lineage, Cell class and subclass (all cells)	MMP24 LRRC75B LSM11 ARTN	6.77e-05	145	67	4	cb534333fba44b241b14fb0d7b74e843f4e7f9f8
ToppCell	LPS-IL1RA-Endothelial-Mes-Like-Gen_Cap\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	OTUD7A DGKI TMEM64 SLC27A3	6.77e-05	145	67	4	90ca38c02325c5c637c32efdef634b54cc3cd105
ToppCell	343B-Epithelial_cells-Epithelial-E_(AT2)-\|343B / Donor, Lineage, Cell class and subclass (all cells)	MMP24 LRRC75B LSM11 ARTN	6.77e-05	145	67	4	80684ec249fa445c1b35f94608a4a6824d53f2d9
Disease	body surface area	HABP4 ARHGEF40 GIPC2 ADO TENT4A PBX4 ASTN2 CADPS2 CABLES1	8.69e-06	643	63	9	EFO_0022196
Disease	Gilles de la Tourette syndrome (is_implicated_in)	DRD4 HCN4	6.69e-05	6	63	2	DOID:11119 (is_implicated_in)
Disease	granule cell layer dentate gyrus volume	DACT1 ASTN2	1.25e-04	8	63	2	EFO_0009403
Disease	creatinine measurement	MMP24 GIPC2 ATXN7 ANKRD9 PBX4 ASTN2 BSN QSOX2 RYR1	2.51e-04	995	63	9	EFO_0004518
Disease	cup-to-disc ratio measurement	FOXD2 TET1 PDXP FAM89B CHSY3 IRX1	3.12e-04	430	63	6	EFO_0006939
Disease	hippocampal tail volume	FOXD2 DACT1	7.49e-04	19	63	2	EFO_0009398
Disease	Attention Deficit Disorder	DRD4 CIC	1.01e-03	22	63	2	C0041671
Disease	Minimal Brain Dysfunction	DRD4 CIC	1.01e-03	22	63	2	C1321905
Disease	Attention deficit hyperactivity disorder	DRD4 CIC	1.20e-03	24	63	2	C1263846
Disease	lean body mass	ARHGEF40 GIPC2 ZNF628 DGKI CABLES1	1.30e-03	379	63	5	EFO_0004995
Disease	intellectual disability (is_implicated_in)	ARID1B DRD4	1.88e-03	30	63	2	DOID:1059 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
RRPAGAAGGGVAARA	EPM2A	66	B3EWF7
AGRGALSRGGDSAPL	ARHGEF40	386	Q8TER5
PRSRRDAGGGAGAAG	PRMT9	6	Q6P2P2
RGAGAARASGPRGGA	CTAG2	46	O75638
AEGAGPGAARGAQRA	C2orf72	71	A6NCS6
PGAARGAQRAARAAG	C2orf72	76	A6NCS6
GGRGASDRDAASGPE	ADO	26	Q96SZ5
AAAAAAAALGSRGGG	EVX2	401	Q03828
RAAAGAGGARAAGPT	ANKRD60	11	Q9BZ19
AGGARAAGPTGGASR	ANKRD60	16	Q9BZ19
GAGGGSLSASRAPAR	GIPC2	26	Q8TF65
EAGARGAAAAAAAPG	ARID1B	41	Q8NFD5
EAPGAAGGLARARSG	DEDD2	51	Q8WXF8
ARAGAGAGTGAGAAA	ASTN2	86	O75129
RPDGLGAAAGGARLS	TFAP2E	11	Q6VUC0
GGSARRPDTGDDAAG	GMCL1	26	Q96IK5
AAAAVGPGAGGAARL	QSOX2	41	Q6ZRP7
LPGAARAAAAAAGAG	MMP24	46	Q9Y5R2
RARGAAAGSGVPAAP	LSM11	76	P83369
ARAGGPGSRARAAGA	ARTN	106	Q5T4W7
RHAAGAANAGPAAGP	FAM89B	66	Q8N5H3
AGGGQLPAAGAARST	BSN	41	Q9UPA5
GGALRAPSQGSGAAA	PRSS22	301	Q9GZN4
RNAGDLAPAGGAASA	CDKN2AIP	41	Q9NXV6
AAAAAGAGPRGGRSP	HABP4	61	Q5JVS0
GGRSPAGASGHRAGA	HABP4	71	Q5JVS0
GRRAGPEAGSEAGAA	LRRC75B	6	Q2VPJ9
RGGAPGSAAGFRASI	LCA10	31	Q71F78
SPGPAAGRAARAAAG	OTUD7A	726	Q8TE49
AGRAARAAAGGTASP	OTUD7A	731	Q8TE49
RAAAGGTASPGGGAR	OTUD7A	736	Q8TE49
RKASGAPAGARGGPA	NOP14	11	P78316
GEPRRAAAAAGGAAA	ATXN7	11	O15265
RGPAAGASAGASAGL	DRD4	16	P21917
ALGAADSEGPARGAG	HCN4	71	Q9Y3Q4
PALDTAAAAGAAGRG	TENT4A	26	Q5XG87
RGGAVARAGTATPGG	PBX4	101	Q9BYU1
AAAAAAGAAGGRGSG	PABPN1	6	Q86U42
ARGSAGAAGGPATAE	ADCY1	146	Q08828
GTLSGAGSRRGAPGA	BORCS6	86	Q96GS4
GALRGAGGAGAAAPR	DACT1	71	Q9NYF0
GVARGFASPLGAGRA	CABLES1	161	Q8TDN4
SERPGAAAAVARGGG	AVEN	26	Q9NQS1
GADPRGAGSAAAAGA	DGKI	86	O75912
SRAGQSAAGAAPGGG	FLNA	6	P21333
GADGGPEASGAARSR	ANKRD9	11	Q96BM1
GRAGGGGAARSVSPS	CADPS2	46	Q86UW7
VSGFPAAAAAGAGRS	EMX1	96	Q04741
AAAAAGAGRSLYGGP	EMX1	101	Q04741
TRAGAAGAGAAAGAL	RYR1	4341	P21817
RAGGGATAPLGGSRA	NUBPL	16	Q8TB37
ASRGAAAAAGSPGPG	FOXD2	86	O60548
AAAAGSPGPGAAAAR	FOXD2	91	O60548
RAGAGTEARAGPGAA	SCRT1	171	Q9BWW7
TEARAGPGAAGAGGR	SCRT1	176	Q9BWW7
AAAGGTGPLAARAGE	TAF10	56	Q12962
GPAAGPGAAAAAARE	PPP1R12C	6	Q9BZL4
AAAGAVGGPGSRSAG	TMEM121B	141	Q9BXQ6
RRGAGAAAGAGPGSL	NPHP3	46	Q7Z494
AAASSGRPGAAELGG	IRX1	36	P78414
AAADGSEPAAGAGRG	RNF215	41	Q9Y6U7
SEPAAGAGRGGARAV	RNF215	46	Q9Y6U7
TRTGPAGGAGAAARA	SHISA7	61	A6NL88
APRSGATAGAAGGRG	CCT4	6	P50991
AGASGRATGPEAAGG	PRR12	356	Q9ULL5
GLRLAGDPSAGDGAA	PDXP	126	Q96GD0
GRLSGANAAAADGPG	TET1	1886	Q8NFU7
FAAPGEGGALAATGR	CIC	401	Q96RK0
GSGDGGAAAPSARPR	CHSY3	156	Q70JA7
GGSRSGSGRPAAANA	TCF24	41	Q7RTU0
LPRGGGASAAAAAAA	TMEM64	46	Q6YI46
GGFLGRGPAAARAAG	SHC2	41	P98077
RGPAAARAAGASGGA	SHC2	46	P98077
ERAAPGAGDAAAGSG	SLC27A3	131	Q5K4L6
RSGGPRSAAAGLLGA	TMEM131	31	Q92545
GGGRRGAAAAAAAMA	TCF20	56	Q9UGU0
GADGRLPSSARAGAG	TNFRSF11A	496	Q9Y6Q6
PSSSAGAGGGRARQG	ZNF628	746	Q5EBL2