Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	Homeodomain-like	HOXB1 NKX2-6 SNAPC2 HOXC11 HOXD3 POGK PROX2	5.93e-06	332	40	7	IPR009057
Domain	Homeobox_metazoa	HOXB1 NKX2-6 HOXC11 HOXD3	4.04e-05	90	40	4	IPR020479
Domain	-	HOXB1 NKX2-6 HOXC11 HOXD3 POGK	3.29e-04	283	40	5	1.10.10.60
Domain	Homeobox_CS	HOXB1 NKX2-6 HOXC11 HOXD3	6.58e-04	186	40	4	IPR017970
Domain	ANTENNAPEDIA	HOXB1 HOXD3	1.20e-03	24	40	2	PS00032
Domain	Homeobox	HOXB1 NKX2-6 HOXC11 HOXD3	1.54e-03	234	40	4	PF00046
Domain	HOMEOBOX_1	HOXB1 NKX2-6 HOXC11 HOXD3	1.59e-03	236	40	4	PS00027
Domain	HOX	HOXB1 NKX2-6 HOXC11 HOXD3	1.61e-03	237	40	4	SM00389
Domain	Homeobox_dom	HOXB1 NKX2-6 HOXC11 HOXD3	1.66e-03	239	40	4	IPR001356
Domain	HOMEOBOX_2	HOXB1 NKX2-6 HOXC11 HOXD3	1.66e-03	239	40	4	PS50071
Domain	Pkinase_C	MAST1 PRKCA	3.65e-03	42	40	2	PF00433
Domain	SAM_2	SFMBT2 SARM1	3.82e-03	43	40	2	PF07647
Domain	AGC-kinase_C	MAST1 PRKCA	6.40e-03	56	40	2	IPR000961
Domain	AGC_KINASE_CTER	MAST1 PRKCA	6.40e-03	56	40	2	PS51285
Domain	S_TK_X	MAST1 PRKCA	6.40e-03	56	40	2	SM00133
Domain	C1_1	PRKCA MYO9B	6.63e-03	57	40	2	PF00130
Domain	ZF_DAG_PE_1	PRKCA MYO9B	8.29e-03	64	40	2	PS00479
Domain	ZF_DAG_PE_2	PRKCA MYO9B	8.29e-03	64	40	2	PS50081
Domain	C1	PRKCA MYO9B	8.54e-03	65	40	2	SM00109
Domain	PE/DAG-bd	PRKCA MYO9B	8.80e-03	66	40	2	IPR002219
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	NAV3 DDN MAST1 CSMD3 TSPOAP1 POGK PLXNB3 EPG5	1.82e-08	407	40	8	12693553
Pubmed	The human HOX gene family.	HOXB1 HOXC11 HOXD3	5.04e-06	29	40	3	2574852
Pubmed	MLL4 is required after implantation, whereas MLL3 becomes essential during late gestation.	EOMES HOXB1 KMT2D	7.51e-06	33	40	3	32439762
Pubmed	A census of human transcription factors: function, expression and evolution.	EOMES HOXB1 SP3 NKX2-6 KMT2D HOXC11 HOXD3 PROX2	7.67e-06	908	40	8	19274049
Pubmed	Regionalized expression of the Dbx family homeobox genes in the embryonic CNS of the mouse.	HOXB1 HOXD3	7.73e-06	4	40	2	8798145
Pubmed	Atlas of Hox gene expression in the developing kidney.	HOXB1 HOXC11 HOXD3	1.16e-05	38	40	3	15042701
Pubmed	Complete mutation analysis panel of the 39 human HOX genes.	HOXB1 HOXC11 HOXD3	1.16e-05	38	40	3	11857506
Pubmed	Lysine demethylase 7a regulates murine anterior-posterior development by modulating the transcription of Hox gene cluster.	HOXB1 HOXC11 HOXD3	1.25e-05	39	40	3	33257809
Pubmed	Quantification of Hox and surfactant protein-B transcription during murine lung development.	HOXB1 HOXC11 HOXD3	1.35e-05	40	40	3	19204410
Pubmed	Lin28a/let-7 pathway modulates the Hox code via Polycomb regulation during axial patterning in vertebrates.	HOXB1 HOXC11 HOXD3	1.46e-05	41	40	3	32479258
Pubmed	Reduction of Hox gene expression by histone H1 depletion.	HOXB1 HOXC11 HOXD3	1.68e-05	43	40	3	22701719
Pubmed	Nomenclature for human homeobox genes.	HOXB1 HOXC11 HOXD3	1.81e-05	44	40	3	1973146
Pubmed	Vertebrate homeobox gene nomenclature.	HOXB1 HOXC11 HOXD3	2.21e-05	47	40	3	1358459
Pubmed	New insights into the role of Jmjd3 and Utx in axial skeletal formation in mice.	HOXB1 HOXC11 HOXD3	2.66e-05	50	40	3	28188179
Pubmed	A physical and transcript map of the MCOLN1 gene region on human chromosome 19p13.3-p13.2.	ARHGEF18 SNAPC2	2.70e-05	7	40	2	11318610
Pubmed	Multiple epigenetic maintenance factors implicated by the loss of Mll2 in mouse development.	HOXB1 KMT2D	2.70e-05	7	40	2	16540515
Pubmed	Localized and transient transcription of Hox genes suggests a link between patterning and the segmentation clock.	HOXB1 HOXD3	3.60e-05	8	40	2	11511348
Pubmed	Usp22 deficiency impairs intestinal epithelial lineage specification in vivo.	EOMES MUC2	3.60e-05	8	40	2	26431380
Pubmed	The thyroid transcription factor-1 gene is a candidate target for regulation by Hox proteins.	HOXB1 HOXD3	4.62e-05	9	40	2	7913891
Pubmed	HMG1 interacts with HOX proteins and enhances their DNA binding and transcriptional activation.	HOXB1 HOXD3	4.62e-05	9	40	2	8890171
Pubmed	Novel gene expression patterns along the proximo-distal axis of the mouse embryo before gastrulation.	AKAP17A SFMBT2	5.77e-05	10	40	2	17302988
Pubmed	Molecular Analysis of the HOXA2-Dependent Degradation of RCHY1.	HOXB1 HOXC11	5.77e-05	10	40	2	26496426
Pubmed	MLL3/MLL4 methyltransferase activities control early embryonic development and embryonic stem cell differentiation in a lineage-selective manner.	EOMES KMT2D	7.05e-05	11	40	2	37012455
Pubmed	The KMT2D Kabuki syndrome histone methylase controls neural crest cell differentiation and facial morphology.	KMT2D COL16A1	1.16e-04	14	40	2	32541010
Pubmed	Altered neuronal lineages in the facial ganglia of Hoxa2 mutant mice.	HOXB1 HOXD3	1.16e-04	14	40	2	18164701
Pubmed	The mouse Ulnaless mutation deregulates posterior HoxD gene expression and alters appendicular patterning.	HOXC11 HOXD3	1.16e-04	14	40	2	9342041
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	DDN ARHGEF18 SP3 FAM193A TSPOAP1	1.30e-04	430	40	5	35044719
Pubmed	A distinct Hox code for the branchial region of the vertebrate head.	HOXB1 HOXD3	1.34e-04	15	40	2	1682814
Pubmed	Pluripotency factors regulate definitive endoderm specification through eomesodermin.	EOMES HOXB1	1.53e-04	16	40	2	21245162
Pubmed	The ESCRT-III Protein CHMP1A Mediates Secretion of Sonic Hedgehog on a Distinctive Subtype of Extracellular Vesicles.	EOMES PRKCA	1.53e-04	16	40	2	30044992
Pubmed	Loss of function of mouse Pax-Interacting Protein 1-associated glutamate rich protein 1a (Pagr1a) leads to reduced Bmp2 expression and defects in chorion and amnion development.	EOMES HOXB1	1.53e-04	16	40	2	24633704
Pubmed	Lgl1 deficiency disrupts hippocampal development and impairs cognitive performance in mice.	EOMES PRKCA	1.53e-04	16	40	2	31415124
Pubmed	Hox3 genes coordinate mechanisms of genetic suppression and activation in the generation of branchial and somatic motoneurons.	HOXB1 HOXD3	1.73e-04	17	40	2	12954718
Pubmed	The guanine nucleotide exchange factor Vav3 regulates differentiation of progenitor cells in the developing mouse retina.	EOMES PRKCA	1.73e-04	17	40	2	25501893
Pubmed	m6A regulation of cortical and retinal neurogenesis is mediated by the redundant m6A readers YTHDFs.	EOMES PRKCA	2.18e-04	19	40	2	36039295
Pubmed	Mutations in MAST1 Cause Mega-Corpus-Callosum Syndrome with Cerebellar Hypoplasia and Cortical Malformations.	EOMES MAST1	2.18e-04	19	40	2	30449657
Pubmed	Porcn-dependent Wnt signaling is not required prior to mouse gastrulation.	EOMES HOXB1	2.42e-04	20	40	2	23760955
Pubmed	Putative complement control protein CSMD3 dysfunction impairs synaptogenesis and induces neurodevelopmental disorders.	EOMES CSMD3	2.94e-04	22	40	2	35245678
Pubmed	Organization of human class I homeobox genes.	HOXB1 HOXD3	2.94e-04	22	40	2	2576652
Pubmed	Independent regulation of vertebral number and vertebral identity by microRNA-196 paralogs.	HOXB1 HOXC11	2.94e-04	22	40	2	26283362
Pubmed	Gene regulation logic in retinal ganglion cell development: Isl1 defines a critical branch distinct from but overlapping with Pou4f2.	EOMES PRKCA	2.94e-04	22	40	2	18460603
Pubmed	PTB deficiency causes the loss of adherens junctions in the dorsal telencephalon and leads to lethal hydrocephalus.	EOMES PRKCA	2.94e-04	22	40	2	22705452
Pubmed	Slit/Robo signaling modulates the proliferation of central nervous system progenitors.	EOMES PRKCA	3.21e-04	23	40	2	23083737
Pubmed	Cdx is crucial for the timing mechanism driving colinear Hox activation and defines a trunk segment in the Hox cluster topology.	HOXB1 HOXD3	3.21e-04	23	40	2	28041967
Pubmed	A dynamic expression survey identifies transcription factors relevant in mouse digestive tract development.	HOXB1 HOXC11 HOXD3	3.43e-04	118	40	3	16971476
Pubmed	Mutations in Spliceosomal Genes PPIL1 and PRP17 Cause Neurodegenerative Pontocerebellar Hypoplasia with Microcephaly.	EOMES MAST1	3.50e-04	24	40	2	33220177
Pubmed	Targeted disruption of the mouse homologue of the Drosophila polyhomeotic gene leads to altered anteroposterior patterning and neural crest defects.	HOXB1 HOXD3	3.50e-04	24	40	2	9367423
Pubmed	Identification of novel Hoxa1 downstream targets regulating hindbrain, neural crest and inner ear development.	HOXB1 HOXD3	3.80e-04	25	40	2	21784065
Pubmed	Genetic ablation of FLRT3 reveals a novel morphogenetic function for the anterior visceral endoderm in suppressing mesoderm differentiation.	EOMES HOXB1	3.80e-04	25	40	2	19056886
Pubmed	Impact of cytosine methylation on DNA binding specificities of human transcription factors.	EOMES HOXB1 SP3 HOXC11 HOXD3	3.85e-04	544	40	5	28473536
Pubmed	Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.	KMT2D FAM193A MUC2 TSPOAP1 MYO9B	4.11e-04	552	40	5	10737800
Pubmed	Fine mapping of human HOX gene clusters.	HOXB1 HOXC11	4.12e-04	26	40	2	8646877
Pubmed	Genomic analysis of gastrulation and organogenesis in the mouse.	EOMES HOXB1	4.12e-04	26	40	2	18061570
Pubmed	Requirement for Pbx1 in skeletal patterning and programming chondrocyte proliferation and differentiation.	HOXB1 HOXD3	4.45e-04	27	40	2	11566859
Pubmed	Complementary functions of Otx2 and Cripto in initial patterning of mouse epiblast.	EOMES HOXB1	4.78e-04	28	40	2	11412024
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	PPP4R1 RTN3 RNF40 MYO9B HDLBP	5.48e-04	588	40	5	38580884
Pubmed	The Trim family of genes and the retina: Expression and functional characterization.	EOMES PRKCA	6.66e-04	33	40	2	30208054
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	PPP4R1 TMEM30A SP3 SNAPC2 FAM193A NXPH3 HDLBP	7.16e-04	1327	40	7	32694731
Pubmed	Loss of Usp9x disrupts cell adhesion, and components of the Wnt and Notch signaling pathways in neural progenitors.	EOMES PRKCA	7.49e-04	35	40	2	28808228
Pubmed	Identification of 10 murine homeobox genes.	HOXC11 HOXD3	8.83e-04	38	40	2	1683707
Pubmed	Loss of Rearranged L-Myc Fusion (RLF) results in defects in heart development in the mouse.	SP3 KMT2D	8.83e-04	38	40	2	27930960
Pubmed	Ranbp1, Deleted in DiGeorge/22q11.2 Deletion Syndrome, is a Microcephaly Gene That Selectively Disrupts Layer 2/3 Cortical Projection Neuron Generation.	EOMES PRKCA	1.03e-03	41	40	2	25452572
Pubmed	Tumor suppressor Nf2 limits expansion of the neural progenitor pool by inhibiting Yap/Taz transcriptional coactivators.	EOMES PRKCA	1.08e-03	42	40	2	23863479
Pubmed	Onecut1 and Onecut2 redundantly regulate early retinal cell fates during development.	EOMES PRKCA	1.13e-03	43	40	2	25228773
Cytoband	12q13.12	DDN KMT2D	5.36e-04	38	41	2	12q13.12
Cytoband	11q13	RTN3 ZFTA	5.03e-03	118	41	2	11q13
Cytoband	Ensembl 112 genes in cytogenetic band chr19p13	MAST1 ARHGEF18 SNAPC2 MYO9B	5.49e-03	797	41	4	chr19p13
Cytoband	Ensembl 112 genes in cytogenetic band chr12q13	DDN KMT2D HOXC11	6.39e-03	423	41	3	chr12q13
GeneFamily	HOXL subclass homeoboxes	HOXB1 HOXC11 HOXD3	6.99e-05	52	28	3	518
GeneFamily	Sterile alpha motif domain containing	SFMBT2 SARM1	8.15e-03	88	28	2	760
Coexpression	GSE3982_MAST_CELL_VS_MAC_UP	DXO RTN3 SP3 ZFTA MUC2	1.27e-05	199	40	5	M5429
Computational	Genes in the cancer module 576.	PPP4R1 COL16A1 TECPR2 SARM1	1.52e-04	110	27	4	MODULE_576
Computational	Genes in the cancer module 503.	PPP4R1 COL16A1 TECPR2 SARM1	1.63e-04	112	27	4	MODULE_503
Disease	Intestinal Neoplasms	PRKCA MUC2	1.23e-04	12	41	2	C0021841
Disease	Intestinal Cancer	PRKCA MUC2	1.23e-04	12	41	2	C0346627
Disease	ischemia (biomarker_via_orthology)	PRKCA MUC2	2.84e-04	18	41	2	DOID:326 (biomarker_via_orthology)
Disease	amyotrophic lateral sclerosis (implicated_via_orthology)	SARM1 EPG5	7.99e-04	30	41	2	DOID:332 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
PDGRKGSPCGEEELP	EOMES	101	O95936
EPPKEGGEARPCVGD	EPG5	101	Q9HCE0
APEAPGTQEGPTCDG	RNF40	121	O75150
SGGGTPAESPGKECD	ARHGEF18	131	Q6ZSZ5
CPDPGEPENGKRIGS	CSMD3	486	Q7Z407
PRGEKGEPGECSCPS	COL16A1	866	Q07092
GKEEGEGATVFPSPC	DDN	496	O94850
ADGESSGEPPGAPKE	FAM193A	361	P78312
KLDGSEPPGGPCEAV	NKX2-6	66	A6NCS4
EKSGAGCSSRDPGPP	TSPOAP1	1346	O95153
QPKPEGPGEDGHCAT	PLXNB3	1351	Q9ULL4
ALKPSACPEPGGGAE	FBXO46	31	Q6PJ61
KPGGDTELIGDVCGP	MUC2	1801	Q02817
QPPSSGPSDGGKDDD	NAV3	401	Q8IVL0
GESCEDKSPPGPASK	HOXD3	181	P31249
IESELPGGGEPPKDC	POGK	586	Q9P215
PGGGEPPKDCDTESM	POGK	591	Q9P215
CADKPGSSPDPSGEV	DXO	196	O77932
PGDLCPPSKDGDASG	MAST1	861	Q9Y2H9
EGRSEPSPPVGGACK	PROX2	266	Q3B8N5
PGGESKANCSPEDPC	PRRT2	91	Q7Z6L0
APPGCPKEAAGDASD	HOXB1	271	P14653
NAKDEVDGGPPCAPG	TMEM30A	6	Q9NV96
PAEPPCSGKGEAKGE	HOXC11	166	O43248
CSGKGEAKGEPEAPP	HOXC11	171	O43248
PGKGCPTLGDEGDTD	GP1BA	276	P07359
CGQDDGPPGSEDPER	NXPH3	21	O95157
PGSPPEKCDSLGSGV	RTN3	451	O95197
SGGKPSPEGPEEESE	PPP4R1	476	Q8TF05
CPGADKGPDTDDPRS	PRKCA	86	P17252
GPPTEPGCSGVDRED	PRR20G	21	P0DPQ3
PPADPCGEEGGESKT	PROB1	651	E7EW31
CGEEGGESKTQEPPA	PROB1	656	E7EW31
VVPEDGSPEKRCPGG	AKAP17A	531	Q02040
PCTGGKPSGDTPDVF	SARM1	551	Q6SZW1
CSKIGPPSPGDDEEE	SP3	66	Q02447
EEGEKCPPTKPEGTE	SFMBT2	791	Q5VUG0
GLGDEPCPADDGPNS	TECPR2	596	O15040
AGEGREAKDCDPGSP	HDLBP	931	Q00341
GDGAGSKAPEETPPA	SNAPC2	281	Q13487
PGQLEESGEKDAPCP	ZAR1L	181	A6NP61
EEEEEGAGVPACPPK	ZFTA	196	C9JLR9
ADTPGPEDGGVKASP	KMT2D	1841	O14686
GSAPETPEDKSKPCG	MYO9B	1266	Q13459