Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	sodium ion transmembrane transporter activity	SLC13A3 TPCN1 SLC6A7 SCN1A SCN2A SCN8A ATP1A4 ATP4A	2.67e-05	171	139	8	GO:0015081
GeneOntologyMolecularFunction	voltage-gated sodium channel activity	TPCN1 SCN1A SCN2A SCN8A	2.98e-05	26	139	4	GO:0005248
GeneOntologyMolecularFunction	alkali metal ion binding	SCN1A SCN2A SCN8A ATP4A	2.98e-05	26	139	4	GO:0031420
GeneOntologyMolecularFunction	sodium ion binding	SCN1A SCN2A SCN8A	1.14e-04	14	139	3	GO:0031402
GeneOntologyMolecularFunction	adenosine-phosphate deaminase activity	AMPD1 AMPD2	1.44e-04	3	139	2	GO:0047623
GeneOntologyMolecularFunction	AMP deaminase activity	AMPD1 AMPD2	1.44e-04	3	139	2	GO:0003876
GeneOntologyMolecularFunction	G protein-coupled receptor activity	OR5W2 OR51T1 VN1R5 MRGPRD GPR26 OR7C2 OR1F2P SSTR4 GPR139 OR6A2 GPR61 OR1I1 OR3A3 SCTR TACR2 OR9A2	4.41e-04	884	139	16	GO:0004930
GeneOntologyMolecularFunction	sodium channel activity	TPCN1 SCN1A SCN2A SCN8A	4.70e-04	52	139	4	GO:0005272
GeneOntologyMolecularFunction	L-ornithine transmembrane transporter activity	SLC7A1 SLC7A2	4.75e-04	5	139	2	GO:0000064
GeneOntologyMolecularFunction	calcium- and calmodulin-responsive adenylate cyclase activity	ADCY5 ADCY6	4.75e-04	5	139	2	GO:0008294
GeneOntologyBiologicalProcess	cilium movement	STK36 BBS1 BBS2 CFAP54 RABL2B RABL2A DNAH12 TACR2 ATP1A4 DYNC1H1	1.06e-05	261	138	10	GO:0003341
GeneOntologyBiologicalProcess	photoreceptor cell morphogenesis	BBS1 RABL2B RABL2A	2.39e-05	9	138	3	GO:0008594
GeneOntologyBiologicalProcess	sodium ion transmembrane transport	SLC13A3 TPCN1 SLC6A7 SCN1A SCN2A SCN8A ATP1A4 ATP4A	8.09e-05	208	138	8	GO:0035725
GeneOntologyBiologicalProcess	cilium movement involved in cell motility	BBS1 BBS2 CFAP54 RABL2B RABL2A DNAH12 TACR2 ATP1A4	8.64e-05	210	138	8	GO:0060294
GeneOntologyBiologicalProcess	sodium ion transport	SLC13A3 TPCN1 SLC6A7 SCN1A SCN2A SCN8A IKBKB ATP1A4 ATP4A	1.00e-04	275	138	9	GO:0006814
GeneOntologyBiologicalProcess	cilium-dependent cell motility	BBS1 BBS2 CFAP54 RABL2B RABL2A DNAH12 TACR2 ATP1A4	1.02e-04	215	138	8	GO:0060285
GeneOntologyBiologicalProcess	cilium or flagellum-dependent cell motility	BBS1 BBS2 CFAP54 RABL2B RABL2A DNAH12 TACR2 ATP1A4	1.02e-04	215	138	8	GO:0001539
GeneOntologyBiologicalProcess	microtubule-based movement	STK36 IFT172 BBS1 BBS2 CFAP54 RABL2B RABL2A DNAH12 TACR2 ATP1A4 DYNC1H1 PCM1	1.22e-04	493	138	12	GO:0007018
GeneOntologyBiologicalProcess	post-Golgi vesicle-mediated transport	ANKFY1 BBS1 BBS2 ASB14 MACF1 DOP1B	1.50e-04	119	138	6	GO:0006892
GeneOntologyCellularComponent	sperm midpiece	IFT172 ADGB RABL2B RABL2A TACR2 ATP1A4	4.06e-06	64	138	6	GO:0097225
GeneOntologyCellularComponent	cilium	TNPO1 ANKS6 IFT172 RTTN BBS1 BBS2 ADCY5 ADCY6 ADGB CFAP54 RABL2B RABL2A DNAH12 TACR2 TMEM262 ATP1A4 USP48 RAB27A PCM1	7.21e-06	898	138	19	GO:0005929
GeneOntologyCellularComponent	motile cilium	IFT172 BBS1 BBS2 ADGB RABL2B RABL2A DNAH12 TACR2 TMEM262 ATP1A4	1.27e-04	355	138	10	GO:0031514
GeneOntologyCellularComponent	voltage-gated sodium channel complex	SCN1A SCN2A SCN8A	1.79e-04	17	138	3	GO:0001518
GeneOntologyCellularComponent	node of Ranvier	SCN1A SCN2A SCN8A	2.96e-04	20	138	3	GO:0033268
GeneOntologyCellularComponent	ciliary basal body	IFT172 RTTN BBS1 BBS2 RABL2B RABL2A PCM1	3.19e-04	195	138	7	GO:0036064
GeneOntologyCellularComponent	intraciliary transport particle B	IFT172 RABL2B RABL2A	3.43e-04	21	138	3	GO:0030992
GeneOntologyCellularComponent	protein phosphatase 4 complex	PPP4R3A PPP4R3C	6.38e-04	6	138	2	GO:0030289
GeneOntologyCellularComponent	intraciliary transport particle	IFT172 RABL2B RABL2A	8.17e-04	28	138	3	GO:0030990
GeneOntologyCellularComponent	pericentriolar material	RABL2B RABL2A PCM1	8.17e-04	28	138	3	GO:0000242
GeneOntologyCellularComponent	axon initial segment	SCN1A SCN2A SCN8A	9.07e-04	29	138	3	GO:0043194
GeneOntologyCellularComponent	sodium channel complex	SCN1A SCN2A SCN8A	9.07e-04	29	138	3	GO:0034706
GeneOntologyCellularComponent	90S preribosome	BMS1 PES1 UTP20	9.07e-04	29	138	3	GO:0030686
GeneOntologyCellularComponent	9+2 motile cilium	IFT172 ADGB RABL2B RABL2A DNAH12 TACR2 ATP1A4	1.04e-03	238	138	7	GO:0097729
GeneOntologyCellularComponent	BBSome	BBS1 BBS2	1.18e-03	8	138	2	GO:0034464
HumanPheno	Cortical dysplasia	CUL4B RTTN SCN1A SCN2A NUP133 DYNC1H1	1.30e-05	56	49	6	HP:0002539
MousePheno	abnormal cholangiocyte morphology	ANKS6 DENND1A CDK5RAP3	8.34e-06	6	106	3	MP:0012236
MousePheno	increased circulating triglyceride level	AMPD2 GPR26 BBS2 PPARA CLOCK PHKB SIDT2 GPR61 MYO18B NR1H4	2.96e-05	262	106	10	MP:0001552
Domain	Na_trans_cytopl	SCN1A SCN2A SCN8A	7.11e-06	6	134	3	PF11933
Domain	Na_trans_cytopl	SCN1A SCN2A SCN8A	7.11e-06	6	134	3	IPR024583
Domain	ARM-type_fold	TNPO1 STK36 IFT172 RTTN INTS1 XPO4 HUWE1 RYR3 PPP4R3A DOCK5 UTP20	3.38e-05	339	134	11	IPR016024
Domain	Na_channel_asu	SCN1A SCN2A SCN8A	4.18e-05	10	134	3	IPR001696
Domain	Na_trans_assoc	SCN1A SCN2A SCN8A	4.18e-05	10	134	3	IPR010526
Domain	Na_trans_assoc	SCN1A SCN2A SCN8A	4.18e-05	10	134	3	PF06512
Domain	KSR1-SAM	KSR2 KSR1	5.11e-05	2	134	2	PF13543
Domain	Secretoglobin_1C1/2	SCGB1C2 SCGB1C1	5.11e-05	2	134	2	IPR028659
Domain	KSR_SAM-like_dom	KSR2 KSR1	5.11e-05	2	134	2	IPR025561
Domain	G_PROTEIN_RECEP_F1_1	OR5W2 OR51T1 VN1R5 MRGPRD GPR26 OR7C2 OR1F2P SSTR4 GPR139 OR6A2 GPR61 OR1I1 OR3A3 TACR2 OR9A2	1.20e-04	685	134	15	PS00237
Domain	G_PROTEIN_RECEP_F1_2	OR5W2 OR51T1 VN1R5 MRGPRD GPR26 OR7C2 OR1F2P SSTR4 GPR139 OR6A2 GPR61 OR1I1 OR3A3 TACR2 OR9A2	1.32e-04	691	134	15	PS50262
Domain	GPCR_Rhodpsn	OR5W2 OR51T1 VN1R5 MRGPRD GPR26 OR7C2 OR1F2P SSTR4 GPR139 OR6A2 GPR61 OR1I1 OR3A3 TACR2 OR9A2	1.34e-04	692	134	15	IPR000276
Domain	AMPD	AMPD1 AMPD2	1.53e-04	3	134	2	IPR006329
Domain	Cat_AA_permease	SLC7A1 SLC7A2	1.53e-04	3	134	2	IPR004755
Domain	Ion_trans_dom	RYR3 TPCN1 KCNH6 SCN1A SCN2A SCN8A	1.72e-04	114	134	6	IPR005821
Domain	Ion_trans	RYR3 TPCN1 KCNH6 SCN1A SCN2A SCN8A	1.72e-04	114	134	6	PF00520
Domain	IQ	ADGB SCN1A SCN2A SCN8A MYO18B	2.92e-04	81	134	5	SM00015
Domain	A/AMP_deam_AS	AMPD1 AMPD2	3.04e-04	4	134	2	IPR006650
Domain	7tm_1	OR5W2 OR51T1 MRGPRD GPR26 OR7C2 OR1F2P SSTR4 GPR139 OR6A2 GPR61 OR1I1 OR3A3 TACR2 OR9A2	3.66e-04	677	134	14	PF00001
Domain	IQ_motif_EF-hand-BS	ADGB SCN1A SCN2A SCN8A MYO18B	4.76e-04	90	134	5	IPR000048
Domain	CAT3	SLC7A1 SLC7A2	5.04e-04	5	134	2	IPR015606
Domain	AA_permease_C	SLC7A1 SLC7A2	5.04e-04	5	134	2	PF13906
Domain	CAT_C	SLC7A1 SLC7A2	5.04e-04	5	134	2	IPR029485
Domain	IQ	ADGB SCN1A SCN2A SCN8A MYO18B	5.53e-04	93	134	5	PS50096
Domain	Channel_four-helix_dom	TPCN1 SCN1A SCN2A SCN8A	7.45e-04	57	134	4	IPR027359
Domain	-	TPCN1 SCN1A SCN2A SCN8A	7.45e-04	57	134	4	1.20.120.350
Domain	Adcy_conserved_dom	ADCY5 ADCY6	7.52e-04	6	134	2	IPR009398
Domain	A_DEAMINASE	AMPD1 AMPD2	7.52e-04	6	134	2	PS00485
Domain	DUF1053	ADCY5 ADCY6	7.52e-04	6	134	2	PF06327
Domain	A_deaminase	AMPD1 AMPD2	7.52e-04	6	134	2	PF00962
Domain	P-type_ATPase_IIC	ATP1A4 ATP4A	7.52e-04	6	134	2	IPR005775
Domain	A/AMP_deaminase_dom	AMPD1 AMPD2	7.52e-04	6	134	2	IPR001365
Domain	DUSP	USP48 USP15	1.05e-03	7	134	2	PS51283
Domain	-	USP48 USP15	1.05e-03	7	134	2	3.30.2230.10
Domain	Pept_C19_DUSP	USP48 USP15	1.05e-03	7	134	2	IPR006615
Domain	GPCR_Rhodpsn_7TM	OR5W2 OR51T1 MRGPRD GPR26 OR7C2 SSTR4 GPR139 OR6A2 GPR61 OR1I1 OR3A3 TACR2 OR9A2	1.07e-03	670	134	13	IPR017452
Domain	AC_N	ADCY5 ADCY6	1.39e-03	8	134	2	IPR032628
Domain	Adcy	ADCY5 ADCY6	1.39e-03	8	134	2	IPR030672
Domain	AC_N	ADCY5 ADCY6	1.39e-03	8	134	2	PF16214
Domain	SCGB	SCGB1C2 SCGB1C1	1.78e-03	9	134	2	PS51311
Domain	RAB	RAB8B RABL2B RABL2A RAB27A	1.88e-03	73	134	4	PS51419
Domain	Uteroglobin	SCGB1C2 SCGB1C1	2.21e-03	10	134	2	PF01099
Domain	Secretoglobin	SCGB1C2 SCGB1C1	2.69e-03	11	134	2	IPR016126
Domain	DHR-1_domain	DOCK5 DOCK7	2.69e-03	11	134	2	IPR027007
Domain	DHR_2	DOCK5 DOCK7	2.69e-03	11	134	2	PS51651
Domain	DHR_1	DOCK5 DOCK7	2.69e-03	11	134	2	PS51650
Domain	DHR-2	DOCK5 DOCK7	2.69e-03	11	134	2	PF06920
Domain	DOCK	DOCK5 DOCK7	2.69e-03	11	134	2	IPR026791
Domain	DOCK_C	DOCK5 DOCK7	2.69e-03	11	134	2	IPR010703
Domain	DOCK-C2	DOCK5 DOCK7	2.69e-03	11	134	2	PF14429
Domain	DHR-2	DOCK5 DOCK7	2.69e-03	11	134	2	IPR027357
Domain	ARM-like	TNPO1 STK36 RTTN XPO4 HUWE1 PPP4R3A UTP20	3.38e-03	270	134	7	IPR011989
Domain	AA_permease_2	SLC7A1 SLC7A2	3.78e-03	13	134	2	PF13520
Domain	AA/rel_permease1	SLC7A1 SLC7A2	3.78e-03	13	134	2	IPR002293
Domain	Znf_hrmn_rcpt	PPARA NR1D1 NR1H4	4.38e-03	46	134	3	IPR001628
Domain	NUCLEAR_REC_DBD_2	PPARA NR1D1 NR1H4	4.38e-03	46	134	3	PS51030
Domain	NUCLEAR_REC_DBD_1	PPARA NR1D1 NR1H4	4.38e-03	46	134	3	PS00031
Domain	ZnF_C4	PPARA NR1D1 NR1H4	4.38e-03	46	134	3	SM00399
Domain	zf-C4	PPARA NR1D1 NR1H4	4.38e-03	46	134	3	PF00105
Domain	Nuclear_hrmn_rcpt	PPARA NR1D1 NR1H4	4.38e-03	46	134	3	IPR001723
Domain	Dynein_heavy_chain_D4_dom	DNAH12 DYNC1H1	4.39e-03	14	134	2	IPR024317
Domain	VitD_rcpt	NR1D1 NR1H4	4.39e-03	14	134	2	IPR000324
Domain	Dynein_heavy_dom-2	DNAH12 DYNC1H1	4.39e-03	14	134	2	IPR013602
Domain	DHC_N2	DNAH12 DYNC1H1	4.39e-03	14	134	2	PF08393
Domain	ATPase_dyneun-rel_AAA	DNAH12 DYNC1H1	4.39e-03	14	134	2	IPR011704
Domain	AAA_8	DNAH12 DYNC1H1	4.39e-03	14	134	2	PF12780
Domain	uDENN	DENND4A DENND1A	4.39e-03	14	134	2	SM00800
Domain	AAA_5	DNAH12 DYNC1H1	4.39e-03	14	134	2	PF07728
Domain	-	PPARA NR1D1 NR1H4	4.65e-03	47	134	3	1.10.565.10
Domain	Nucl_hrmn_rcpt_lig-bd	PPARA NR1D1 NR1H4	4.93e-03	48	134	3	IPR000536
Domain	HOLI	PPARA NR1D1 NR1H4	4.93e-03	48	134	3	SM00430
Domain	Hormone_recep	PPARA NR1D1 NR1H4	4.93e-03	48	134	3	PF00104
Domain	HEAT	TNPO1 STK36 UTP20	4.93e-03	48	134	3	PF02985
Domain	DHC_fam	DNAH12 DYNC1H1	5.05e-03	15	134	2	IPR026983
Domain	uDENN	DENND4A DENND1A	5.05e-03	15	134	2	PF03456
Domain	Dynein_heavy	DNAH12 DYNC1H1	5.05e-03	15	134	2	PF03028
Domain	Dynein_heavy_dom	DNAH12 DYNC1H1	5.05e-03	15	134	2	IPR004273
Domain	DENN	DENND4A DENND1A	5.74e-03	16	134	2	SM00799
Domain	MAM_1	TMPRSS15 ALK	5.74e-03	16	134	2	PS00740
Domain	DENN	DENND4A DENND1A	5.74e-03	16	134	2	PF02141
Domain	dDENN	DENND4A DENND1A	5.74e-03	16	134	2	PF03455
Domain	ATPase_P-typ_TM_dom	ATP1A4 ATP4A	5.74e-03	16	134	2	IPR023298
Domain	UDENN	DENND4A DENND1A	5.74e-03	16	134	2	PS50946
Domain	DDENN	DENND4A DENND1A	5.74e-03	16	134	2	PS50947
Domain	-	ATP1A4 ATP4A	5.74e-03	16	134	2	1.20.1110.10
Domain	dDENN	DENND4A DENND1A	5.74e-03	16	134	2	SM00801
Domain	dDENN_dom	DENND4A DENND1A	5.74e-03	16	134	2	IPR005112
Domain	uDENN_dom	DENND4A DENND1A	5.74e-03	16	134	2	IPR005113
Domain	DENN	DENND4A DENND1A	5.74e-03	16	134	2	PS50211
Domain	DENN_dom	DENND4A DENND1A	5.74e-03	16	134	2	IPR001194
Domain	ATPase_P-typ_cation-transptr_C	ATP1A4 ATP4A	6.48e-03	17	134	2	IPR006068
Domain	A/G_cyclase_CS	ADCY5 ADCY6	6.48e-03	17	134	2	IPR018297
Domain	Cation_ATPase_C	ATP1A4 ATP4A	6.48e-03	17	134	2	PF00689
Domain	TPR-like_helical_dom	TANC2 IFT172 PSMD11 TEX11 CFAP54 FKBP5	6.75e-03	233	134	6	IPR011990
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	CUL4B TNPO1 TANC2 AMPD2 DENND4A ANKS6 EYA4 IFT172 BBS1 BBS2 XPO4 CLOCK DENND1A ADCY6 PPP4R3A NUP205 DOCK5 STK3 KSR1 DOCK7 NUP133 UBAC2 USP15 DYNC1H1 RUSF1	9.48e-11	1321	139	25	27173435
Pubmed	Variable patterns of mutation density among NaV1.1, NaV1.2 and NaV1.6 point to channel-specific functional differences associated with childhood epilepsy.	SCN1A SCN2A SCN8A	6.25e-08	3	139	3	32845893
Pubmed	Comparison and optimization of in silico algorithms for predicting the pathogenicity of sodium channel variants in epilepsy.	SCN1A SCN2A SCN8A	6.25e-08	3	139	3	28518218
Pubmed	Reduced sodium current in Purkinje neurons from Nav1.1 mutant mice: implications for ataxia in severe myoclonic epilepsy in infancy.	SCN1A SCN2A SCN8A	6.25e-08	3	139	3	17928448
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	CUL4B TNPO1 AMPD2 GNPDA1 ANKFY1 NIF3L1 PSMD11 HUWE1 PPP4R3A NUP205 FASN LUC7L2 FDPS PES1 NUP133 ANP32E MACF1 IKBKB USP48 USP15 FKBP5 DYNC1H1	8.02e-08	1455	139	22	22863883
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	EPHB4 TANC2 STK36 ANKS6 EP400 RTTN KSR2 INTS1 TRMT11 PPARA ATG2A HUWE1 DENND1A TPCN1 PCNX2 SLC7A1 FASN SCN8A DYNC1H1	9.58e-08	1105	139	19	35748872
Pubmed	Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development.	RTTN PSMD11 HUWE1 PPP4R3A NUP205 DOCK5 FASN DNAH12 CCNB3 FER1L4 PES1 MACF1 MYO18B	1.10e-07	496	139	13	31343991
Pubmed	Nav1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation.	SCN1A SCN2A SCN8A	2.49e-07	4	139	3	17537961
Pubmed	Sodium channel expression and transcript variation in the developing brain of human, Rhesus monkey, and mouse.	SCN1A SCN2A SCN8A	2.49e-07	4	139	3	35031483
Pubmed	Abnormal changes in voltage-gated sodium channels subtypes NaV1.1, NaV1.2, NaV1.3, NaV1.6 and CaM/CaMKII pathway in low-grade astrocytoma.	SCN1A SCN2A SCN8A	2.49e-07	4	139	3	29578003
Pubmed	Neuronal voltage-gated ion channels are genetic modifiers of generalized epilepsy with febrile seizures plus.	SCN1A SCN2A SCN8A	2.49e-07	4	139	3	21156207
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	CUL4B TNPO1 INTS1 BMS1 HUWE1 NUP205 FASN PES1 DOCK7 NUP133 MACF1 UTP20 DYNC1H1 PCM1	4.00e-07	653	139	14	22586326
Pubmed	Defining the membrane proteome of NK cells.	INTS1 DHRS13 PSMD11 HUWE1 NUP205 KSR1 SLC7A1 FASN CDK5RAP3 GYG1 PES1 NUP133 ADAM17 MCTP2 FKBP5 DYNC1H1 RUSF1 PCM1	1.04e-06	1168	139	18	19946888
Pubmed	A 'toothache tree' alkylamide inhibits Aδ mechanonociceptors to alleviate mechanical pain.	SCN1A SCN2A SCN8A	1.24e-06	6	139	3	23652591
Pubmed	HiQuant: Rapid Postquantification Analysis of Large-Scale MS-Generated Proteomics Data.	KSR2 KSR1 FKBP5	1.24e-06	6	139	3	27086506
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	NUDT19 TNPO1 BMS1 XPO4 PSMD11 HUWE1 DENND1A NUP205 FASN LUC7L2 FDPS PES1 DOCK7 NUP133 ANP32E IKBKB FKBP5 RAB27A DYNC1H1 PCM1	1.25e-06	1440	139	20	30833792
Pubmed	Diagnostic yield of genetic testing in epileptic encephalopathy in childhood.	SCN1A SCN2A SCN8A	2.16e-06	7	139	3	25818041
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	TNPO1 TANC2 INTS1 PSMD11 HUWE1 DOCK5 FASN GSDME LUC7L2 MACF1 USP48 DYNC1H1	4.18e-06	582	139	12	20467437
Pubmed	International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels.	SCN1A SCN2A SCN8A	5.16e-06	9	139	3	16382098
Pubmed	Expression pattern of neuronal and skeletal muscle voltage-gated Na+ channels in the developing mouse heart.	SCN1A SCN2A SCN8A	5.16e-06	9	139	3	15746173
Pubmed	Recruitment of PCM1 to the centrosome by the cooperative action of DISC1 and BBS4: a candidate for psychiatric illnesses.	BBS1 BBS2 PCM1	5.16e-06	9	139	3	18762586
Pubmed	HIV-host interactome revealed directly from infected cells.	PSMD11 HUWE1 FASN NUP133 PDIA2 ADAM17 RUSF1	6.31e-06	172	139	7	27375898
Pubmed	A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis.	BBS1 BBS2 PCM1	7.34e-06	10	139	3	17574030
Pubmed	DAZ-interacting Protein 1 (Dzip1) Phosphorylation by Polo-like Kinase 1 (Plk1) Regulates the Centriolar Satellite Localization of the BBSome Protein during the Cell Cycle.	BBS1 BBS2 PCM1	7.34e-06	10	139	3	27979967
Pubmed	A BBSome subunit links ciliogenesis, microtubule stability, and acetylation.	BBS1 BBS2 PCM1	7.34e-06	10	139	3	19081074
Pubmed	C16orf72/HAPSTR1 is a molecular rheostat in an integrated network of stress response pathways.	CUL4B TNPO1 ANKFY1 PSMD11 HUWE1 USP15	8.76e-06	119	139	6	35776542
Pubmed	The centriolar satellite protein AZI1 interacts with BBS4 and regulates ciliary trafficking of the BBSome.	BBS1 BBS2 PCM1	1.01e-05	11	139	3	24550735
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	CUL4B TNPO1 ANKFY1 IFT172 PSMD11 HUWE1 PPP4R3A NUP205 FASN PES1 NUP133 DYNC1H1	1.05e-05	638	139	12	33239621
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR5W2 OR51T1 OR7C2 OR1F2P OR6A2 OR1I1 SCGB1C2 OR9A2 SCGB1C1	1.13e-05	346	139	9	14611657
Pubmed	Nav1.2 haplodeficiency in excitatory neurons causes absence-like seizures in mice.	SCN1A SCN2A SCN8A	1.34e-05	12	139	3	30175250
Pubmed	Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors.	DENND4A RAB8B DENND1A RAB27A	1.46e-05	37	139	4	20937701
Pubmed	SCGB1C1 Plays a Critical Role in Suppression of Allergic Airway Inflammation through the Induction of Regulatory T Cell Expansion.	SCGB1C2 SCGB1C1	1.59e-05	2	139	2	38892470
Pubmed	"New" hepatic fat activates PPARalpha to maintain glucose, lipid, and cholesterol homeostasis.	PPARA FASN	1.59e-05	2	139	2	16054078
Pubmed	Kinase suppressor of Ras 2 (KSR2) regulates tumor cell transformation via AMPK.	KSR2 KSR1	1.59e-05	2	139	2	22801368
Pubmed	Reduction of Kcnt1 is therapeutic in mouse models of SCN1A and SCN8A epilepsy.	SCN1A SCN8A	1.59e-05	2	139	2	37901435
Pubmed	An Scn1a epilepsy mutation in Scn8a alters seizure susceptibility and behavior.	SCN1A SCN8A	1.59e-05	2	139	2	26410685
Pubmed	Neuronal death and perinatal lethality in voltage-gated sodium channel alpha(II)-deficient mice.	SCN1A SCN2A	1.59e-05	2	139	2	10827969
Pubmed	RABL2 Is Required for Hepatic Fatty Acid Homeostasis and Its Dysfunction Leads to Steatosis and a Diabetes-Like State.	RABL2B RABL2A	1.59e-05	2	139	2	27732084
Pubmed	Differential role of sodium channels SCN1A and SCN2A gene polymorphisms with epilepsy and multiple drug resistance in the north Indian population.	SCN1A SCN2A	1.59e-05	2	139	2	19694741
Pubmed	Commonalities and distinctions between two neurodevelopmental disorder subtypes associated with SCN2A and SCN8A variants and literature review.	SCN2A SCN8A	1.59e-05	2	139	2	35348308
Pubmed	Genetic interaction of BBS1 mutations with alleles at other BBS loci can result in non-Mendelian Bardet-Biedl syndrome.	BBS1 BBS2	1.59e-05	2	139	2	12677556
Pubmed	Knockout of adenylyl cyclase isoform 5 or 6 differentially modifies the β1-adrenoceptor-mediated inotropic response.	ADCY5 ADCY6	1.59e-05	2	139	2	31009605
Pubmed	Electrophysiological properties of two axonal sodium channels, Nav1.2 and Nav1.6, expressed in mouse spinal sensory neurones.	SCN2A SCN8A	1.59e-05	2	139	2	15760941
Pubmed	Differential expression of two sodium channel subtypes in human brain.	SCN1A SCN2A	1.59e-05	2	139	2	1317301
Pubmed	Clinical exome sequencing identifies two novel mutations of the SCN1A and SCN2A genes in Moroccan patients with epilepsy: a case series.	SCN1A SCN2A	1.59e-05	2	139	2	31439038
Pubmed	The prognostic biomarker L-homoarginine is a substrate of the cationic amino acid transporters CAT1, CAT2A and CAT2B.	SLC7A1 SLC7A2	1.59e-05	2	139	2	28684763
Pubmed	Analysis of relative gene dosage and expression differences of the paralogs RABL2A and RABL2B by Pyrosequencing.	RABL2B RABL2A	1.59e-05	2	139	2	20138207
Pubmed	The importance of cationic amino acid transporter expression in human skin.	SLC7A1 SLC7A2	1.59e-05	2	139	2	12787129
Pubmed	The calcium paradoxon of renin release: calcium suppresses renin exocytosis by inhibition of calcium-dependent adenylate cyclases AC5 and AC6.	ADCY5 ADCY6	1.59e-05	2	139	2	17068292
Pubmed	Scn8a Antisense Oligonucleotide Is Protective in Mouse Models of SCN8A Encephalopathy and Dravet Syndrome.	SCN1A SCN8A	1.59e-05	2	139	2	31943325
Pubmed	Severe epilepsy, retardation, and dysmorphic features with a 2q deletion including SCN1A and SCN2A.	SCN1A SCN2A	1.59e-05	2	139	2	15249644
Pubmed	Adenylyl cyclase 5-generated cAMP controls cerebral vascular reactivity during diabetic hyperglycemia.	ADCY5 ADCY6	1.59e-05	2	139	2	31162142
Pubmed	CLOCK is involved in the circadian transactivation of peroxisome-proliferator-activated receptor alpha (PPARalpha) in mice.	PPARA CLOCK	1.59e-05	2	139	2	15500444
Pubmed	Human cationic amino acid transporters hCAT-1, hCAT-2A, and hCAT-2B: three related carriers with distinct transport properties.	SLC7A1 SLC7A2	1.59e-05	2	139	2	9174363
Pubmed	Differential regulation of vascular tone and remodeling via stimulation of type 2 and type 6 adenylyl cyclases in the ductus arteriosus.	ADCY5 ADCY6	1.59e-05	2	139	2	20431059
Pubmed	Reduced expression of Na(v)1.6 sodium channels and compensation by Na(v)1.2 channels in mice heterozygous for a null mutation in Scn8a.	SCN2A SCN8A	1.59e-05	2	139	2	18601978
Pubmed	FGF14 N-terminal splice variants differentially modulate Nav1.2 and Nav1.6-encoded sodium channels.	SCN2A SCN8A	1.59e-05	2	139	2	19465131
Pubmed	Direct regulation of CLOCK expression by REV-ERB.	NR1D1 CLOCK	1.59e-05	2	139	2	21479263
Pubmed	Control of cationic amino acid transport and retroviral receptor functions in a membrane protein family.	SLC7A1 SLC7A2	1.59e-05	2	139	2	8195186
Pubmed	SCN1A and SCN2A polymorphisms are associated with response to valproic acid in Chinese epilepsy patients.	SCN1A SCN2A	1.59e-05	2	139	2	30693367
Pubmed	Block of a subset of sodium channels exacerbates experimental autoimmune encephalomyelitis.	SCN2A SCN8A	1.59e-05	2	139	2	23735284
Pubmed	Association between SCN1A and SCN2A mutations and clinical/EEG features in Chinese patients from epilepsy or severe seizures.	SCN1A SCN2A	1.59e-05	2	139	2	29649454
Pubmed	Human cationic amino acid transporters are not affected by direct nitros(yl)ation.	SLC7A1 SLC7A2	1.59e-05	2	139	2	32008093
Pubmed	Ciliogenesis is reciprocally regulated by PPARA and NR1H4/FXR through controlling autophagy in vitro and in vivo.	PPARA NR1H4	1.59e-05	2	139	2	29771182
Pubmed	Adenylyl cyclase subtype-specific compartmentalization: differential regulation of L-type Ca2+ current in ventricular myocytes.	ADCY5 ADCY6	1.59e-05	2	139	2	23609114
Pubmed	Adenylyl cyclase type 5 protein expression during cardiac development and stress.	ADCY5 ADCY6	1.59e-05	2	139	2	19734365
Pubmed	Monocarboxylate transporter 1 in the liver modulates high-fat diet-induced obesity and hepatic steatosis in mice.	PPARA HUWE1	1.59e-05	2	139	2	36933792
Pubmed	Identification of a low affinity, high capacity transporter of cationic amino acids in mouse liver.	SLC7A1 SLC7A2	1.59e-05	2	139	2	8385111
Pubmed	Effects of SCN1A and SCN2A polymorphisms on responsiveness to valproic acid monotherapy in epileptic children.	SCN1A SCN2A	1.59e-05	2	139	2	33096315
Pubmed	Farnesol, an isoprenoid, improves metabolic abnormalities in mice via both PPARα-dependent and -independent pathways.	PPARA NR1H4	1.59e-05	2	139	2	21862726
Pubmed	Sodium channel expression within chronic multiple sclerosis plaques.	SCN2A SCN8A	1.59e-05	2	139	2	17805013
Pubmed	Bile acids induce the expression of the human peroxisome proliferator-activated receptor alpha gene via activation of the farnesoid X receptor.	PPARA NR1H4	1.59e-05	2	139	2	12554753
Pubmed	Missense mutations in sodium channel SCN1A and SCN2A predispose children to encephalopathy with severe febrile seizures.	SCN1A SCN2A	1.59e-05	2	139	2	26311622
Pubmed	Aberrant regulation of a poison exon caused by a non-coding variant in a mouse model of Scn1a-associated epileptic encephalopathy.	SCN1A SCN8A	1.59e-05	2	139	2	33411788
Pubmed	Two novel human RAB genes with near identical sequence each map to a telomere-associated region: the subtelomeric region of 22q13.3 and the ancestral telomere band 2q13.	RABL2B RABL2A	1.59e-05	2	139	2	10444334
Pubmed	Sex-dependent relationship of polymorphisms in CLOCK and REV-ERBα genes with body mass index and lipid levels in children.	NR1D1 CLOCK	1.59e-05	2	139	2	38092833
Pubmed	Variants in RABL2A causing male infertility and ciliopathy.	RABL2B RABL2A	1.59e-05	2	139	2	33075816
Pubmed	REV-ERBα and the clock gene machinery in mouse peripheral tissues: a possible role as a synchronizing hinge.	NR1D1 CLOCK	1.59e-05	2	139	2	22824754
Pubmed	Regulation of cationic amino acid transporter (CAT) gene expression.	SLC7A1 SLC7A2	1.59e-05	2	139	2	8878860
Pubmed	Cell signalling-mediating insulin increase of mRNA expression for cationic amino acid transporters-1 and -2 and membrane hyperpolarization in human umbilical vein endothelial cells.	SLC7A1 SLC7A2	1.59e-05	2	139	2	15064952
Pubmed	Renal cancer and malformations in relatives of patients with Bardet-Biedl syndrome.	BBS1 BBS2	1.59e-05	2	139	2	11096143
Pubmed	KSR2 is an essential regulator of AMP kinase, energy expenditure, and insulin sensitivity.	KSR2 KSR1	1.59e-05	2	139	2	19883615
Pubmed	Nutrient-sensing nuclear receptors PPARα and FXR control liver energy balance.	PPARA NR1H4	1.59e-05	2	139	2	28287408
Pubmed	The developmental changes of Na(v)1.1 and Na(v)1.2 expression in the human hippocampus and temporal lobe.	SCN1A SCN2A	1.59e-05	2	139	2	21377452
Pubmed	A new perspective on NAFLD: Focusing on the crosstalk between peroxisome proliferator-activated receptor alpha (PPARα) and farnesoid X receptor (FXR).	PPARA NR1H4	1.59e-05	2	139	2	35988420
Pubmed	RABL2 positively controls localization of GPCRs in mammalian primary cilia.	RABL2B RABL2A	1.59e-05	2	139	2	30578315
Pubmed	Characterization of cationic amino acid transporters (hCATs) 1 and 2 in human skin.	SLC7A1 SLC7A2	1.59e-05	2	139	2	18172665
Pubmed	Reduced peroxisome proliferator-activated receptor-α and bile acid nuclear receptor NR1H4/FXR may affect the hepatic immune microenvironment of biliary atresia.	PPARA NR1H4	1.59e-05	2	139	2	36090996
Pubmed	Stimulation of renin secretion by catecholamines is dependent on adenylyl cyclases 5 and 6.	ADCY5 ADCY6	1.59e-05	2	139	2	21282557
Pubmed	Persistent Nav1.1 and Nav1.6 currents drive spinal locomotor functions through nonlinear dynamics.	SCN1A SCN8A	1.59e-05	2	139	2	37665666
Pubmed	SR9009 administered for one day after myocardial ischemia-reperfusion prevents heart failure in mice by targeting the cardiac inflammasome.	NR1D1 CLOCK	1.59e-05	2	139	2	31602405
Pubmed	The voltage-gated sodium channel Scn8a is a genetic modifier of severe myoclonic epilepsy of infancy.	SCN1A SCN8A	1.59e-05	2	139	2	17881658
Pubmed	Kinase Suppressor of Ras 2 (KSR2) expression in the brain regulates energy balance and glucose homeostasis.	KSR2 KSR1	1.59e-05	2	139	2	28180061
Pubmed	USP15 promotes the apoptosis of degenerative nucleus pulposus cells by suppressing the PI3K/AKT signalling pathway.	USP15 FKBP5	1.59e-05	2	139	2	33135363
Pubmed	PPARalpha gene expression is up-regulated by LXR and PXR activators in the small intestine.	PPARA NR1H4	1.59e-05	2	139	2	18448072
Pubmed	Cloning and sequence of partial cDNAs encoding the human type V and VI adenylyl cyclases and subsequent RNA-quantification in various tissues.	ADCY5 ADCY6	1.59e-05	2	139	2	10481931
Pubmed	Concomitant PPARα and FXR Activation as a Putative Mechanism of NASH Improvement after Gastric Bypass Surgery: a GEO Datasets Analysis.	PPARA NR1H4	1.59e-05	2	139	2	30206765
Pubmed	Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2.	SCN1A SCN2A SCN8A	1.74e-05	13	139	3	15123669
Pubmed	Intrinsic protein-protein interaction-mediated and chaperonin-assisted sequential assembly of stable bardet-biedl syndrome protein complex, the BBSome.	BBS1 BBS2 PCM1	1.74e-05	13	139	3	22500027
Pubmed	Latent CSN-CRL complexes are crucial for curcumin-induced apoptosis and recruited during adipogenesis to lipid droplets via small GTPase RAB18.	CUL4B USP48 USP15	2.74e-05	15	139	3	37091236
Interaction	EPHA1 interactions	TNPO1 EP400 XPO4 HUWE1 NUP205 GSDME PES1 SMG9 ALK DYNC1H1	3.01e-06	235	130	10	int:EPHA1
Interaction	OPALIN interactions	RTTN INTS1 XPO4 NUP205 DOCK5 SLC7A2 UTP20 RUSF1 DOP1B	8.70e-06	209	130	9	int:OPALIN
Interaction	CD70 interactions	INTS1 XPO4 ADCY6 NUP205 SLC7A1 GSDME NUP133 UTP20	1.24e-05	166	130	8	int:CD70
Interaction	SCN4B interactions	SCN1A SCN2A SCN8A	1.43e-05	8	130	3	int:SCN4B
Interaction	PPP2R3C interactions	RABL2B SMG9 IKBKB DYNC1H1 PCM1	1.74e-05	50	130	5	int:PPP2R3C
Interaction	MYCBP2 interactions	CUL4B HUWE1 NR1D1 TLR10 DOCK5 STK3 DOCK7 MACF1 USP15 DYNC1H1 PCM1	1.95e-05	355	130	11	int:MYCBP2
Interaction	COMTD1 interactions	TNPO1 INTS1 XPO4 PPP4R3A NUP205 CDK5RAP3 GSDME NUP133	4.72e-05	200	130	8	int:COMTD1
GeneFamily	Sodium voltage-gated channel alpha subunits	SCN1A SCN2A SCN8A	1.31e-05	9	99	3	1203
GeneFamily	Bardet-Biedl syndrome associated\|BBSome	IFT172 BBS1 BBS2	1.97e-04	21	99	3	980
GeneFamily	Mitogen-activated protein kinase kinase kinases\|RAF family	KSR2 KSR1	2.94e-04	5	99	2	1157
GeneFamily	RAB like GTPases	RABL2B RABL2A	2.94e-04	5	99	2	394
GeneFamily	Adenosine deaminase family	AMPD1 AMPD2	4.39e-04	6	99	2	1302
GeneFamily	Bardet-Biedl syndrome associated\|BBSome	BBS1 BBS2	8.13e-04	8	99	2	1122
GeneFamily	G protein-coupled receptors, Class A orphans	MRGPRD GPR26 GPR139 GPR61	8.85e-04	78	99	4	262
GeneFamily	Adenylate cyclases\|Deafness associated genes	ADCY5 ADCY6	1.30e-03	10	99	2	53
GeneFamily	Nuclear hormone receptors	PPARA NR1D1 NR1H4	2.44e-03	49	99	3	71
GeneFamily	Secretoglobins	SCGB1C2 SCGB1C1	2.59e-03	14	99	2	734
GeneFamily	Rhomboid family	RHBDD1 UBAC2	2.59e-03	14	99	2	926
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	EYA4 IFT172 SLC13A3 ADGB CFAP54 RABL2A DNAH12	1.31e-06	176	138	7	dee780cfa85234a7cd7bf440b66b84cec959893e
ToppCell	Control-Epithelial_cells-AT2\|Control / group, cell type (main and fine annotations)	TANC2 FREM2 SLC7A2 FASN SCN1A SCTR ACOXL	1.52e-06	180	138	7	198b19e7910b4a8cc7e820c525ab357c7f99f578
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STK36 TMPRSS15 TEX11 RYR3 FREM2 SCN2A ATP1A4	1.76e-06	184	138	7	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STK36 TMPRSS15 TEX11 RYR3 FREM2 SCN2A ATP1A4	1.76e-06	184	138	7	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STK36 TMPRSS15 TEX11 RYR3 FREM2 SCN2A ATP1A4	1.76e-06	184	138	7	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2-D175\|Adult / Lineage, Cell type, age group and donor	TANC2 SLC7A1 SLC7A2 SCN1A SCTR MCTP2 ACOXL	2.03e-06	188	138	7	ec38def1fdbb34ed9b30244806975bd5a4370164
ToppCell	nucseq-Epithelial-Epithelial_Alveolar-AT2-AT2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	TANC2 FREM2 SLC7A2 FASN SCN1A SCTR ACOXL	2.42e-06	193	138	7	fd4d3c0d7caf8a2fff5b3d901fc28d19a8163cdf
ToppCell	nucseq-Epithelial-Epithelial_Alveolar-AT2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	TANC2 FREM2 SLC7A2 FASN SCN1A SCTR ACOXL	2.42e-06	193	138	7	f3cc7cfdbc164a4ed42f87647111522b7d393bcb
ToppCell	moderate-Epithelial-Ciliated\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	KLHL6 SLC13A3 ADGB CFAP54 RABL2B RABL2A DNAH12	2.59e-06	195	138	7	3486eae5fdb062a75a907b896c9d7b396d2aa195
ToppCell	moderate-Epithelial-Ciliated\|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	SLC13A3 ADGB SLC7A2 CFAP54 RABL2B RABL2A DNAH12	2.59e-06	195	138	7	e80f5cdf0b18066b3e6c2f5452e58f101c67932c
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW09-Macroglial-Glia_progenitor_cell\|GW09 / Sample Type, Dataset, Time_group, and Cell type.	INTS1 ASB14 PREX2 TPCN1 KCNH6 SLC7A1 FKBP5	2.68e-06	196	138	7	7be50b9156394dea44d7b8b476d4dd516abfafae
ToppCell	E16.5-samps-Mesenchymal-Matrix_fibroblast-_fetal-Mature_Fibroblast_1\|E16.5-samps / Age Group, Lineage, Cell class and subclass	NR1D1 PREX2 RYR3 GYG1 MACF1 NR1H4	1.19e-05	163	138	6	f1ec2625b52664308968b01d8e0275e1e0751480
ToppCell	droplet-Lung-LUNG-30m-Myeloid-plasmacytoid_dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KSR2 KMO FDPS AACS MCTP2 ATP4A	1.42e-05	168	138	6	e156297a7515e785a9e79a9676700bd3a9d92b98
ToppCell	droplet-Lung-LUNG-30m-Myeloid-Plasmacytoid_Dendritic\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KSR2 KMO FDPS AACS MCTP2 ATP4A	1.42e-05	168	138	6	32e0bc0873baa13027241063283ef26d2aab56f5
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	NPL SLC13A3 PPARA TPCN1 KCNH6 FKBP5	2.09e-05	180	138	6	f8bdfd7bf7b3d52c659a29d8f5f80858e79da83e
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NPL RTTN SLC13A3 PPARA KMO TPCN1	2.30e-05	183	138	6	facd6dbe0851b537d70a899ac7485714ab27d071
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NPL SLC13A3 PPARA KMO TPCN1 KCNH6	2.30e-05	183	138	6	84b64cf728629c3af9a8d2ed15b93adf562c54b8
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L5-6_LAMP5_SFTA3_(Lamp5_Lhx6_2)\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	EYA4 SSTR4 PREX2 FREM2 SLC7A2 ALK	2.37e-05	184	138	6	e2de27cee3ea80f9b7a9a7884ceceeaa67b3214a
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Degenerative_Descending_Thin_Limb_Cell_Type_3\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TANC2 DENND4A ADCY5 CFAP54 SCTR MCTP2	2.59e-05	187	138	6	c31130fc2f9f882944b2ba366a034a03f051c4b9
ToppCell	CD8+_Memory_T_cell-CV-7\|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster	ANKFY1 XPO4 HUWE1 MACF1 MCTP2 DOP1B	2.92e-05	191	138	6	9454f642c3621370fa23640b631301346b300950
ToppCell	COVID-19-lung-AT2\|lung / Disease (COVID-19 only), tissue and cell type	TANC2 FREM2 FASN SCN1A SCTR ACOXL	2.92e-05	191	138	6	276455a64c2c3503d5048615762eb2ee37f0ac70
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	FREM2 SLC7A2 FASN FDPS SCN1A ACOXL	3.01e-05	192	138	6	cc9911e182a289779a2612bc213daae5607689e7
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2-D122\|Adult / Lineage, Cell type, age group and donor	FREM2 FASN FDPS SCN1A SCTR ACOXL	3.01e-05	192	138	6	06013a07e3a873b1d1c0451643c528593ac32a9c
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2\|Adult / Lineage, Cell type, age group and donor	TANC2 FREM2 FASN SCN1A SCTR ACOXL	3.10e-05	193	138	6	738f4f0a9ddde2432b429ab46838e353b1790589
ToppCell	Posterior_cortex-Neuronal\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	KSR2 PCNX2 SLC6A7 GPR61 SCN2A SCN8A	3.10e-05	193	138	6	b4989e3436e84dbec3789b46057e0f7a0ebf09d4
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L6_LAMP5_C1QL2\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	EYA4 SSTR4 PREX2 DOCK5 SLC7A2 ALK	3.10e-05	193	138	6	64a37dae3d631713b06d94691f5dcdb200dfef5e
ToppCell	critical-Epithelial-Ciliated\|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	ADGB SLC7A2 CFAP54 RABL2B RABL2A DNAH12	3.38e-05	196	138	6	27b855c6e1ae44f16db998cf0e81bd686b9cee7e
ToppCell	NS-control-d_0-4-Epithelial-Ciliated\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	KLHL6 ADGB CFAP54 RABL2B RABL2A DNAH12	3.38e-05	196	138	6	d46ab80554dd3c1cc81e1938ea2acfd5e85c6d2a
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TANC2 ADCY5 SLC7A1 SCN2A SCTR NR1H4	3.47e-05	197	138	6	7e93a97b5ac5ae2f77a4b3141082a1463fed00dd
ToppCell	control-Epithelial-Ciliated\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	KLHL6 ADGB CFAP54 RABL2B RABL2A DNAH12	3.47e-05	197	138	6	e453d085182364ca347cbcc9dc995c62c3353016
ToppCell	control-Epithelial-Ciliated\|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	KLHL6 ADGB CFAP54 RABL2B RABL2A DNAH12	3.47e-05	197	138	6	d4e963c1f82996371bf3d63578ee9fce8e00c5a8
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_alveolar-AT2\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	TANC2 FREM2 FASN SCN1A SCTR ACOXL	3.57e-05	198	138	6	2e2a4e1756bba6f4fbe529559a97d2993c890b4b
ToppCell	Biopsy_IPF-Epithelial-Ciliated\|Biopsy_IPF / Sample group, Lineage and Cell type	IFT172 ADGB CFAP54 RABL2B RABL2A DNAH12	3.78e-05	200	138	6	bb8c99156e547a8eb6599b6b6bc3c66bf77af7f8
ToppCell	kidney_cells-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CUL4B CYP4V2 SLC13A3 PPARA ADCY6	8.91e-05	145	138	5	47a3bb973a508d3097213a2d86ad1ce697af9bae
Drug	Cimetidine [51481-61-9]; Down 200; 15.8uM; PC3; HT_HG-U133A	TMPRSS15 ANKFY1 SSTR4 PREX2 PPP4R3A PCNX2 SLC7A1 SIDT2 GPC3	3.00e-06	196	137	9	4063_DN
Disease	epilepsy (implicated_via_orthology)	SLC13A3 KCNH6 SCN1A SCN2A SCN8A ATP1A4 ATP4A DYNC1H1	8.43e-07	163	134	8	DOID:1826 (implicated_via_orthology)
Disease	generalized epilepsy with febrile seizures plus 2 (implicated_via_orthology)	SCN1A SCN2A SCN8A	1.07e-05	10	134	3	DOID:0111294 (implicated_via_orthology)
Disease	Dravet syndrome (implicated_via_orthology)	SCN1A SCN2A SCN8A	1.07e-05	10	134	3	DOID:0080422 (implicated_via_orthology)
Disease	generalized epilepsy with febrile seizures plus (implicated_via_orthology)	SCN1A SCN2A SCN8A	1.96e-05	12	134	3	DOID:0060170 (implicated_via_orthology)
Disease	Benign familial infantile epilepsy	SCN2A SCN8A	6.12e-05	3	134	2	cv:C5575231
Disease	Neurodevelopmental Disorders	TANC2 ADCY5 SCN1A SCN2A SCN8A	6.76e-05	93	134	5	C1535926
Disease	Polydactyly	IFT172 BBS1 BBS2 FREM2 GPC3	2.00e-04	117	134	5	C0152427
Disease	pontocerebellar hypoplasia (implicated_via_orthology)	AMPD1 AMPD2	2.03e-04	5	134	2	DOID:0060264 (implicated_via_orthology)
Disease	Familial benign neonatal epilepsy	SCN2A SCN8A	3.03e-04	6	134	2	C0220669
Disease	free androgen index	CYP3A7 PPARA ADCY6 GPR139 DOCK5 SIDT2 USP48 NR1H4	3.22e-04	374	134	8	EFO_0007005
Disease	NEPHROTIC SYNDROME, STEROID-RESISTANT, AUTOSOMAL RECESSIVE	ANKFY1 NUP205 NUP133	3.40e-04	30	134	3	C1868672
Disease	familial hemiplegic migraine (implicated_via_orthology)	ATP1A4 ATP4A	4.24e-04	7	134	2	DOID:0060178 (implicated_via_orthology)
Disease	Seizure, Febrile, Simple	SCN1A SCN2A	4.24e-04	7	134	2	C0149886
Disease	Seizure, Febrile, Complex	SCN1A SCN2A	4.24e-04	7	134	2	C0751057
Disease	Febrile Convulsions	SCN1A SCN2A	7.22e-04	9	134	2	C0009952
Disease	Generalized Epilepsy with Febrile Seizures Plus	SCN1A SCN2A	7.22e-04	9	134	2	C3502809
Disease	Mesothelioma	GPC3 EID1 MYO18B	8.60e-04	41	134	3	C0025500
Disease	Muscle Weakness	AMPD1 GYG1	8.99e-04	10	134	2	C0151786
Disease	cystic kidney disease (implicated_via_orthology)	EPHB4 IFT172	8.99e-04	10	134	2	DOID:2975 (implicated_via_orthology)
Disease	circadian rhythm	NPL DENND1A SCN8A PDIA2 ANP32E	9.10e-04	163	134	5	EFO_0004354
Disease	cocaine use	CLOCK SCN1A	1.10e-03	11	134	2	C3496069
Disease	early infantile epileptic encephalopathy (implicated_via_orthology)	CDK5RAP3 SCN8A	1.10e-03	11	134	2	DOID:0050709 (implicated_via_orthology)
Disease	Bardet-Biedl syndrome (implicated_via_orthology)	BBS1 BBS2	1.10e-03	11	134	2	DOID:1935 (implicated_via_orthology)
Disease	Drugs used in diabetes use measurement	KSR2 ADCY5 PPP4R3A SCTR MACF1 ACOXL	1.12e-03	255	134	6	EFO_0009924
Disease	nervous system disease (implicated_via_orthology)	ATP1A4 ATP4A	1.31e-03	12	134	2	DOID:863 (implicated_via_orthology)
Disease	Retinitis Pigmentosa	CYP4V2 IFT172 BBS1 BBS2	1.32e-03	104	134	4	C0035334
Disease	fetal genotype effect measurement, body weights and measures	ADCY5 GPR139 FKBP5	1.45e-03	49	134	3	EFO_0004324, EFO_0007959
Disease	hepatocellular carcinoma (implicated_via_orthology)	PPARA GPC3 NR1H4	1.45e-03	49	134	3	DOID:684 (implicated_via_orthology)
Disease	Infantile Severe Myoclonic Epilepsy	SCN1A SCN2A	1.55e-03	13	134	2	C0751122
Disease	Epilepsy	TANC2 SCN1A SCN2A SCN8A	1.57e-03	109	134	4	C0014544
Disease	Bardet-Biedl syndrome (is_implicated_in)	BBS1 BBS2	1.80e-03	14	134	2	DOID:1935 (is_implicated_in)
Disease	polycystic kidney disease (implicated_via_orthology)	ANKS6 IFT172	1.80e-03	14	134	2	DOID:0080322 (implicated_via_orthology)
Disease	body weight	RTTN KSR2 BBS2 HUWE1 TEX11 DENND1A ADCY5 ADCY6 GPR139 SLC7A1 FASN DNAH12 GYG1 PCM1	1.82e-03	1261	134	14	EFO_0004338
Disease	lifestyle measurement, alcohol consumption measurement	DENND1A GPR139 NUP205 CFAP54	1.90e-03	115	134	4	EFO_0007878, EFO_0010724
Disease	MMR-related febrile seizures	SCN1A SCN2A	2.07e-03	15	134	2	EFO_0006519
Disease	platelet storage pool deficiency (implicated_via_orthology)	DOCK7 RAB27A	2.07e-03	15	134	2	DOID:2223 (implicated_via_orthology)
Disease	Seasonal Affective Disorder	NR1D1 CLOCK	2.36e-03	16	134	2	C0085159
Disease	Early infantile epileptic encephalopathy with suppression bursts	SCN1A SCN2A	2.36e-03	16	134	2	C0393706
Disease	platelet component distribution width	EPHB4 RTTN TEX11 ADCY5 DOCK5 SIDT2 DOCK7 MACF1 USP15 ACOXL	2.40e-03	755	134	10	EFO_0007984
Disease	Obesity	KSR2 BBS1 BBS2 PPARA FASN	2.49e-03	205	134	5	C0028754
Disease	Glycogen storage disease	PHKB GYG1	2.66e-03	17	134	2	cv:C0017919
Disease	Bardet-Biedl syndrome 1 (disorder)	BBS1 BBS2	2.66e-03	17	134	2	C2936862
Disease	alcoholic hepatitis (biomarker_via_orthology)	PPARA NR1H4	2.99e-03	18	134	2	DOID:12351 (biomarker_via_orthology)
Disease	Febrile seizure (within the age range of 3 months to 6 years)	SCN1A SCN2A	2.99e-03	18	134	2	HP_0002373
Disease	Bardet-Biedl syndrome	BBS1 BBS2	2.99e-03	18	134	2	cv:C0752166
Disease	Diabetes Mellitus, Non-Insulin-Dependent	KSR2 PPARA ADCY5 SCTR USP48	3.44e-03	221	134	5	C0011860
Disease	Profound Mental Retardation	FASN SCN1A SCN8A DYNC1H1	3.77e-03	139	134	4	C0020796
Disease	Mental Retardation, Psychosocial	FASN SCN1A SCN8A DYNC1H1	3.77e-03	139	134	4	C0025363
Disease	Mental deficiency	FASN SCN1A SCN8A DYNC1H1	3.77e-03	139	134	4	C0917816
Disease	palmitoylcarnitine measurement	ATP1A4 ACOXL	4.06e-03	21	134	2	EFO_0021044
Disease	Intellectual Disability	TANC2 RTTN FASN SCN1A SCN8A MACF1 DYNC1H1	4.42e-03	447	134	7	C3714756
Disease	anxiety disorder (implicated_via_orthology)	SCN1A SCN2A	4.46e-03	22	134	2	DOID:2030 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
LIDSLFIMDQFKAAE	EP400	1031	Q96L91
AMNAEFEAAEQFDLL	CDCA5	236	Q96FF9
RLLDEMFDSTASQFL	CFAP54	396	Q96N23
LLMEAEDRLNFLLSE	CFAP54	2271	Q96N23
VADLVLMLIDASFGF	AGAP9	41	Q5VTM2
FEELRQEVALFAAAM	AACS	131	Q86V21
NFKFAFRAMVLDLEL	ADGB	861	Q8N7X0
VMTLNELFARFDKLA	ADCY6	401	O43306
SDIFQAVLFDDELLM	GSDME	311	O60443
MELLSAAKFFQLEAL	BTBD11	996	A6QL63
DSDMFINVDYLTELL	B3GALT5	156	Q9Y2C3
FKELEFLSMANVELS	ANP32E	41	Q9BTT0
NLDTFLDDMNFLLAL	AMPD1	236	P23109
ELLIQAGFDVNFMLD	ASB14	331	A6NK59
VMTLNELFARFDKLA	ADCY5	491	O95622
LREVFESMNLTAYDL	AMPD2	456	Q01433
VADLVLMLIDASFGF	BMS1	146	Q14692
AVAALMAFLFDLKAL	SLC7A2	396	P52569
IMDTSTFLLRFILDD	ATG2A	1146	Q2TAZ0
FLAFNMDTVDDLAFL	ACOXL	421	Q9NUZ1
FEDSEELAALQMLFS	ALG1L	106	Q6GMV1
GTINEAFLFEDMITL	CCNB3	1001	Q8WWL7
EIQEAFLFFMASILK	DENND4A	561	Q7Z401
DAMGFLLLFDLTNEQ	RAB27A	91	P51159
ANVEEAFFTLARDIM	RAB8B	156	Q92930
LLNRTALFEVMFSEE	PPP4R3A	201	Q6IN85
EFSAEENFLILTEMA	NR1H4	291	Q96RI1
DEAMAELAIADNVFL	NUP205	356	Q92621
ELAIADNVFLFLMES	NUP205	361	Q92621
IFADSECLLLSVMAF	OR5W2	106	Q8NH69
DFMDEIFQELENFSL	RABL2A	186	Q9UBK7
DFMDEIFQELENFSL	RABL2B	186	Q9UNT1
ALSIDDMLVEANFIL	RAD9B	256	Q6WBX8
DMLVEANFILATLAD	RAD9B	261	Q6WBX8
DDVFLTELMKLANRF	ANKFY1	131	Q9P2R3
ASESFLLAAFLNLAM	FKBP5	311	Q13451
LAALASDFSEDMLQE	NUP133	976	Q8WUM0
LRDVASESVALFFML	GPR61	36	Q9BZJ8
SESVALFFMLLLDLT	GPR61	41	Q9BZJ8
LEAANLFQFLRMVDA	KLHL6	146	Q8WZ60
FMGSAFVILSDLELN	MCTP2	271	Q6DN12
ILTEFMENGALDSFL	EPHB4	691	P54760
TLAMDTILANARFFD	GNPDA1	161	P46926
TLDMDLVFLFDNSKI	IKBKB	381	O14920
FLAMVFQDLLTNKDD	INTS1	476	Q8N201
LYLEDSDFLENLMST	NUDT19	311	A8MXV4
INVDDMVNELFDSLF	GPC3	161	P51654
LQAFFLVADDIMDSS	FDPS	161	P14324
EVLELFLDPAFFQMD	DOP1B	1971	Q9Y3R5
DFEEMNLSLLSARSF	KSR2	631	Q6VAB6
AFDLQQMIDEIFLSS	TMPRSS15	86	P98073
ATDMDSDDSLLLFVL	FREM2	586	Q5SZK8
DFLLFGVLFEATMID	FER1L4	426	A9Z1Z3
AVIMFILNFEDLAQL	KCNH6	121	Q9H252
FDQLAFIEELFSLMV	EID1	156	Q9Y6B2
LAAFLDTFLAANSML	GPR26	81	Q8NDV2
ISEVLFNELAFFKLM	PCM1	1676	Q15154
DISESFLLDFFMVSI	PCNX2	1261	A6NKB5
AFDLQERPSFSLLMD	KSR1	861	Q8IVT5
TQLNELLLFVAAAFM	OR3A3	201	P47888
LLESSVLVAMAFDRF	OR51T1	111	Q8NGJ9
FFFLSNDEMLEILSE	DNAH12	996	Q6ZR08
LNLAAADLLFLFSMA	MRGPRD	66	Q8TDS7
LLEEAAALNLSIMFD	GDPD2	341	Q9HCC8
DVATFLALAQDALDM	PDIA2	186	Q13087
DSFLLAVMAIDRFVA	OR1I1	111	O60431
LIIEFDNMFSSATDI	HUWE1	2491	Q7Z6Z7
LEEALLFSGQFMDAL	MACF1	6656	Q9UPN3
NMAFIFLNRFLDLTD	IFT172	1591	Q9UG01
YFISELADMDNFLLA	OR1F2P	101	Q96R84
ILFLNEACLFEIMFS	PPP4R3C	201	Q6ZMV5
LLSAMFDFSEKLNSL	NR1D1	516	P20393
EMIFNLADTHLFFND	EYA4	411	O95677
MDADTLVLANIDDLF	GYG1	101	P46976
VFDELMDKFSNDLSL	KMO	326	O15229
DIIQSMASFFAIEDL	BBS2	566	Q9BXC9
EVLTRFFMDQASFEL	DOCK5	1026	Q9H7D0
FFLNDLLSVMDRGFV	DOCK7	1076	Q96N67
NQFLDELMELEIFLA	CDK5RAP3	351	Q96JB5
AFDLVMLLNDPDTEL	ANKS6	396	Q68DC2
FTILEDFLDIMNEQA	CYP4V2	156	Q6ZWL3
ASIDLLEDVFSNLDM	DENND1A	566	Q8TEH3
EDVLSTDMIFNNFLA	DYNC1H1	2366	Q14204
ENVAAIFLGLLDFFM	CCDC168	2256	Q8NDH2
SDLELMAQSIIFIFA	CYP3A7	291	P24462
VFVDFLLEDFILNMQ	GPR139	81	Q6DWJ6
QDLAFLSMLNDIAAV	FASN	446	P49327
SLRFLQLELSEMEAF	BBS1	171	Q8NFJ9
FLFLSGLIMASAIEE	SLC13A3	91	Q8WWT9
AADMILLDDNFASIV	ATP4A	756	P20648
LVLLMFNEGEEFSLE	CUL4B	751	Q13620
FIVNLALADLCMAAF	TACR2	71	P21452
NNEVIFMALDLASLA	DHRS13	86	Q6UX07
DLSDFYMSQDVFLLI	PHKB	581	Q93100
DNTLLTEFILFLMAV	OR9A2	186	Q8NGT5
NFLLLGFAEDSDMQL	OR7C2	11	O60412
DMSTAELTDFILAIF	OR6A2	196	O95222
FFELDAMDHLQSFIA	LUC7L2	81	Q9Y383
FAMKFNALELDDSDI	PPARA	361	Q07869
MDLTLFAAEAIALNR	MKNK1	396	Q9BUB5
FLFGVDEQLLSALVM	NPL	196	Q9BXD5
LFADILNDVAMFLEI	RUSF1	166	Q96GQ5
LIALFDTLLLNFMEV	RTTN	1211	Q86VV8
SDKNALFNLMFLDLD	UTP20	201	O75691
DMFLDLLNFAAETLV	TRMT11	351	Q7Z4G4
AMFGSFLVLLTLDDD	SIDT2	806	Q8NBJ9
LLQFAVAEFMDEPDF	RHBDD1	121	Q8TEB9
MALRELNIAFNFLTD	TLR10	466	Q9BXR5
ELMDFITQNLFTGLD	OVCH1	286	Q7RTY7
SLLDLFLDMEAATGQ	PSMD11	91	O00231
NDEFFMDFLQTLLVG	SCGB1C2	26	P0DMR2
FLDSEVNLFLVPFMD	SMG9	421	Q9H0W8
LLNLAVADELFMLSV	SSTR4	86	P31391
VDFLLAQGASIALMD	TANC2	1116	Q9HCD6
FIQAADLLMADFKVL	RNF216	371	Q9NWF9
SFMDLKALLSSLNDF	NIF3L1	26	Q9GZT8
MNDSLFVSLDRLLLE	SIX6OS1	1	Q8N1H7
MLLTLGLDSQFAFLE	SLC6A7	391	Q99884
QLLCFPFALDMDADL	STK36	986	Q9NRP7
FMILLSSGALAFEDI	SCN1A	1226	P35498
ELDFLMEALIISKFN	ALK	1161	Q9UM73
MLLEQFSFDIAEEAS	ADAM17	316	P78536
AADMILLDDNFASIV	ATP1A4	751	Q13733
TQLMLEALDGFFLAI	CLOCK	111	O15516
DFDFLKNLSLEELQM	STK3	436	Q13188
IDNVAILFNFLMDFL	XPO4	821	Q9C0E2
TFIDALRDLDDALSM	PES1	126	O00541
AAVMAFLFDLKDLVD	SLC7A1	396	P30825
ADSDQLFRMVAEVFI	RYR3	3286	Q15413
SPEDAMEIQLFFELA	SCTR	361	P47872
FMILLSSGALAFEDI	SCN2A	1216	Q99250
LVGEVMEFLADLLFF	TTC41P	986	Q6P2S7
LVDFPINDLDMSEFL	USP15	851	Q9Y4E8
FMILLSSGALAFEDI	SCN8A	1206	Q9UQD0
AFEQTMFLSRALEEI	TEX11	701	Q8IYF3
EQAMLEDTLVALFDL	PREX2	1331	Q70Z35
NDEFFMDFLQTLLVG	SCGB1C1	26	Q8TD33
AEAQLAELDLLASMF	RWDD2B	36	P57060
ALMLHIDSFIENLFA	TNPO1	216	Q92973
FLVFSQMLAGLDLDL	MYO18B	756	Q8IUG5
MASSAELDFNLQALL	PYDC2	1	Q56P42
AMFFNRLSLEFLAIE	TMEM262	96	E9PQX1
IMNLLLAVVFDTFND	TPCN1	311	Q9ULQ1
AEIMLFSLDLLLFST	VN1R5	11	Q7Z5H4
VLSALFDFLLIEAMQ	UBAC2	101	Q8NBM4
DAQEFSKLFMSLLED	USP48	181	Q86UV5