Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	pyruvate dehydrogenase (acetyl-transferring) kinase activity	PDK1 PDK2 PDK3	8.22e-07	5	88	3	GO:0004740
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	HOXA9 HOXA10 HOXD1 KLF1 NKX2-4 ZIC5 ZNF335 TLX3 FOXB2 ETS1 SOX18 GATA5 HSF4 CUX1 TBX6	3.27e-04	1244	88	15	GO:0000978
GeneOntologyMolecularFunction	3-chloroallyl aldehyde dehydrogenase activity	ALDH1A2 ALDH1A1	3.97e-04	7	88	2	GO:0004028
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	HOXA9 HOXA10 HOXD1 KLF1 NKX2-4 ZIC5 TLX3 FOXB2 ETS1 SOX18 GATA5 SAMD7 HMX1 HSF4 CUX1 TBX6	4.05e-04	1412	88	16	GO:0000981
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	HOXA9 HOXA10 HOXD1 KLF1 NKX2-4 ZIC5 ZNF335 TLX3 FOXB2 ETS1 SOX18 GATA5 HSF4 CUX1 TBX6	4.11e-04	1271	88	15	GO:0000987
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	HOXA9 HOXA10 HOXD1 KLF1 NKX2-4 ZIC5 ZNF335 TLX3 FOXB2 ETS1 SOX18 GATA5 HMX1 HSF4 CUX1 TBX6	5.80e-04	1459	88	16	GO:0000977
GeneOntologyBiologicalProcess	regulation of acetyl-CoA biosynthetic process from pyruvate	PDK1 PDK2 PDK3	2.79e-07	4	86	3	GO:0010510
GeneOntologyBiologicalProcess	regulation of acyl-CoA biosynthetic process	PDK1 PDK2 PDK3	6.96e-07	5	86	3	GO:0050812
GeneOntologyBiologicalProcess	embryonic morphogenesis	HOXA9 HOXA10 ALDH1A2 DKK1 ZIC5 CECR2 ARMC5 CDH23 SOX18 ALDH1A1 ATP2B2 AHDC1 TCTN1 TBX6	1.39e-06	713	86	14	GO:0048598
GeneOntologyBiologicalProcess	tissue morphogenesis	RBM15 ALDH1A2 DKK1 ZIC5 CECR2 ARMC5 FIGNL2 DCHS1 SOX18 GATA5 ALDH1A1 AHDC1 TCTN1 TBX6	2.51e-06	750	86	14	GO:0048729
GeneOntologyBiologicalProcess	embryo development	HOXA9 HOXA10 ALDH1A2 DKK1 HOXD1 KLF1 ZIC5 CECR2 ZNF335 ARMC5 DCHS1 SMG9 CDH23 SOX18 ALDH1A1 ATP2B2 AHDC1 TCTN1 TBX6	5.62e-06	1437	86	19	GO:0009790
GeneOntologyBiologicalProcess	acetyl-CoA biosynthetic process from pyruvate	PDK1 PDK2 PDK3	1.94e-05	13	86	3	GO:0006086
GeneOntologyBiologicalProcess	chordate embryonic development	HOXA9 ALDH1A2 DKK1 HOXD1 KLF1 ZIC5 CECR2 ZNF335 ARMC5 DCHS1 SMG9 SOX18 TCTN1 TBX6	2.15e-05	906	86	14	GO:0043009
GeneOntologyBiologicalProcess	embryo development ending in birth or egg hatching	HOXA9 ALDH1A2 DKK1 HOXD1 KLF1 ZIC5 CECR2 ZNF335 ARMC5 DCHS1 SMG9 SOX18 TCTN1 TBX6	2.83e-05	929	86	14	GO:0009792
GeneOntologyBiologicalProcess	regulation of sulfur metabolic process	PDK1 PDK2 PDK3	4.56e-05	17	86	3	GO:0042762
GeneOntologyBiologicalProcess	inner ear receptor cell differentiation	CECR2 CDH23 ADGRV1 ATP2B2 CUX1	5.08e-05	96	86	5	GO:0060113
GeneOntologyBiologicalProcess	heart morphogenesis	RBM15 ALDH1A2 DKK1 SLIT3 DCHS1 SOX18 GATA5 TBX6	5.84e-05	321	86	8	GO:0003007
GeneOntologyBiologicalProcess	inner ear receptor cell stereocilium organization	CECR2 CDH23 ADGRV1 ATP2B2	7.06e-05	53	86	4	GO:0060122
GeneOntologyBiologicalProcess	mechanoreceptor differentiation	CECR2 CDH23 ADGRV1 ATP2B2 CUX1	7.45e-05	104	86	5	GO:0042490
GeneOntologyBiologicalProcess	acetyl-CoA biosynthetic process	PDK1 PDK2 PDK3	7.58e-05	20	86	3	GO:0006085
GeneOntologyBiologicalProcess	epithelium development	ZNF703 RBM15 ALDH1A2 DKK1 ZIC5 CECR2 FIGNL2 DCHS1 CDH23 SOX18 GATA5 ALDH1A1 HSF4 ATP2B2 TCTN1 CUX1 TBX6	1.02e-04	1469	86	17	GO:0060429
GeneOntologyBiologicalProcess	cochlea development	CECR2 DCHS1 CDH23 ATP2B2	1.23e-04	61	86	4	GO:0090102
GeneOntologyBiologicalProcess	thyroid hormone generation	SLC5A5 SLC16A10 DUOXA2	1.51e-04	25	86	3	GO:0006590
GeneOntologyBiologicalProcess	animal organ morphogenesis	HOXA9 RBM15 ALDH1A2 DKK1 ZNF335 SLIT3 DCHS1 CDH23 SOX18 GATA5 SAMD7 ALDH1A1 ATP2B2 AHDC1 TBX6	2.21e-04	1269	86	15	GO:0009887
GeneOntologyBiologicalProcess	sensory organ development	ALDH1A2 CECR2 DCHS1 SMG9 CDH23 SAMD7 ALDH1A1 ADGRV1 HSF4 ATP2B2 CUX1	2.21e-04	730	86	11	GO:0007423
GeneOntologyBiologicalProcess	inner ear receptor cell development	CECR2 CDH23 ADGRV1 ATP2B2	2.46e-04	73	86	4	GO:0060119
GeneOntologyBiologicalProcess	morphogenesis of an epithelium	RBM15 ALDH1A2 ZIC5 CECR2 FIGNL2 DCHS1 SOX18 ALDH1A1 TCTN1 TBX6	2.51e-04	619	86	10	GO:0002009
GeneOntologyBiologicalProcess	9-cis-retinoic acid biosynthetic process	ALDH1A2 ALDH1A1	2.55e-04	6	86	2	GO:0042904
GeneOntologyBiologicalProcess	9-cis-retinoic acid metabolic process	ALDH1A2 ALDH1A1	2.55e-04	6	86	2	GO:0042905
GeneOntologyBiologicalProcess	heart valve development	DKK1 SLIT3 DCHS1 GATA5	3.18e-04	78	86	4	GO:0003170
GeneOntologyBiologicalProcess	phenol-containing compound metabolic process	SLC5A5 MOXD1 ATP2B2 SLC16A10 DUOXA2	3.21e-04	142	86	5	GO:0018958
GeneOntologyBiologicalProcess	pattern specification process	HOXA9 HOXA10 ALDH1A2 DKK1 DCHS1 SOX18 GATA5 TCTN1 TBX6	3.43e-04	526	86	9	GO:0007389
GeneOntologyBiologicalProcess	epithelial tube morphogenesis	RBM15 ALDH1A2 ZIC5 CECR2 DCHS1 SOX18 TCTN1 TBX6	3.73e-04	421	86	8	GO:0060562
GeneOntologyBiologicalProcess	thyroid hormone metabolic process	SLC5A5 SLC16A10 DUOXA2	3.81e-04	34	86	3	GO:0042403
GeneOntologyBiologicalProcess	mesoderm formation	DKK1 ARMC5 AHDC1 TBX6	3.85e-04	82	86	4	GO:0001707
GeneOntologyBiologicalProcess	mesoderm morphogenesis	DKK1 ARMC5 AHDC1 TBX6	4.61e-04	86	86	4	GO:0048332
GeneOntologyBiologicalProcess	heart induction	DKK1 GATA5	4.73e-04	8	86	2	GO:0003129
GeneOntologyBiologicalProcess	proximal/distal pattern formation	HOXA9 HOXA10 ALDH1A2	4.91e-04	37	86	3	GO:0009954
GeneOntologyBiologicalProcess	gland development	HOXA9 HOXA10 ZNF703 ALDH1A2 RIPK3 KLF1 ARMC5 ATP2B2 SLC29A1	5.26e-04	558	86	9	GO:0048732
GeneOntologyBiologicalProcess	acetyl-CoA metabolic process	PDK1 PDK2 PDK3	5.74e-04	39	86	3	GO:0006084
GeneOntologyBiologicalProcess	hypoxia-inducible factor-1alpha signaling pathway	PDK1 PDK3	6.07e-04	9	86	2	GO:0097411
GeneOntologyBiologicalProcess	regulation of heart morphogenesis	DKK1 GATA5	6.07e-04	9	86	2	GO:2000826
GeneOntologyBiologicalProcess	regulation of purine nucleotide biosynthetic process	PDK1 PDK2 PDK3	6.18e-04	40	86	3	GO:1900371
GeneOntologyBiologicalProcess	regulation of nucleotide biosynthetic process	PDK1 PDK2 PDK3	6.18e-04	40	86	3	GO:0030808
GeneOntologyBiologicalProcess	embryonic organ morphogenesis	HOXA9 ALDH1A2 CDH23 SOX18 ALDH1A1 ATP2B2 TBX6	6.61e-04	351	86	7	GO:0048562
GeneOntologyBiologicalProcess	inner ear development	CECR2 DCHS1 CDH23 ADGRV1 ATP2B2 CUX1	6.65e-04	253	86	6	GO:0048839
GeneOntologyBiologicalProcess	neuron projection development	HMCN2 DKK1 CECR2 ZNF335 SLIT3 FIGNL2 CDH23 LGR6 ADGRV1 ATP2B2 TCTN1 CUX1 ADCYAP1 TBX6	8.24e-04	1285	86	14	GO:0031175
GeneOntologyBiologicalProcess	regionalization	HOXA9 HOXA10 ALDH1A2 DKK1 SOX18 GATA5 TCTN1 TBX6	8.57e-04	478	86	8	GO:0003002
GeneOntologyBiologicalProcess	neuron development	HMCN2 DKK1 CECR2 ZNF335 SLIT3 FIGNL2 CDH23 SAMD7 LGR6 ADGRV1 ATP2B2 TCTN1 CUX1 ADCYAP1 TBX6	9.83e-04	1463	86	15	GO:0048666
GeneOntologyBiologicalProcess	acyl-CoA biosynthetic process	PDK1 PDK2 PDK3	1.12e-03	49	86	3	GO:0071616
GeneOntologyBiologicalProcess	thioester biosynthetic process	PDK1 PDK2 PDK3	1.12e-03	49	86	3	GO:0035384
GeneOntologyBiologicalProcess	anatomical structure formation involved in morphogenesis	RBM15 DKK1 ZIC5 CECR2 ARMC5 ETS1 DCHS1 SOX18 GATA5 ALDH1A1 ATP2B2 AHDC1 TCTN1 PRX TBX6	1.13e-03	1483	86	15	GO:0048646
Domain	BCDHK_Adom3	PDK1 PDK2 PDK3	9.70e-07	5	87	3	PF10436
Domain	His_kinase_dom	PDK1 PDK2 PDK3	9.70e-07	5	87	3	IPR005467
Domain	HIS_KIN	PDK1 PDK2 PDK3	9.70e-07	5	87	3	PS50109
Domain	-	PDK1 PDK2 PDK3	9.70e-07	5	87	3	1.20.140.20
Domain	BCDHK/PDK_N	PDK1 PDK2 PDK3	9.70e-07	5	87	3	IPR018955
Domain	Homeobox_metazoa	HOXA9 HOXA10 HOXD1 NKX2-4 TLX3 HMX1	3.90e-06	90	87	6	IPR020479
Domain	Homeobox_CS	HOXA9 HOXA10 HOXD1 NKX2-4 TLX3 HMX1 CUX1	2.59e-05	186	87	7	IPR017970
Domain	HATPase_c	PDK1 PDK2 PDK3	7.57e-05	18	87	3	SM00387
Domain	HATPase_c	PDK1 PDK2 PDK3	8.96e-05	19	87	3	PF02518
Domain	-	PDK1 PDK2 PDK3	1.05e-04	20	87	3	3.30.565.10
Domain	Homeobox	HOXA9 HOXA10 HOXD1 NKX2-4 TLX3 HMX1 CUX1	1.11e-04	234	87	7	PF00046
Domain	HOMEOBOX_1	HOXA9 HOXA10 HOXD1 NKX2-4 TLX3 HMX1 CUX1	1.17e-04	236	87	7	PS00027
Domain	HOX	HOXA9 HOXA10 HOXD1 NKX2-4 TLX3 HMX1 CUX1	1.20e-04	237	87	7	SM00389
Domain	HATPase_C	PDK1 PDK2 PDK3	1.22e-04	21	87	3	IPR003594
Domain	HOMEOBOX_2	HOXA9 HOXA10 HOXD1 NKX2-4 TLX3 HMX1 CUX1	1.26e-04	239	87	7	PS50071
Domain	Homeobox_dom	HOXA9 HOXA10 HOXD1 NKX2-4 TLX3 HMX1 CUX1	1.26e-04	239	87	7	IPR001356
Domain	-	HOXA9 HOXA10 HOXD1 NKX2-4 TLX3 HMX1 CUX1	3.54e-04	283	87	7	1.10.10.60
Domain	LAM_G_DOMAIN	CNTNAP3B SLIT3 CNTNAP3	7.32e-04	38	87	3	PS50025
Domain	Laminin_G_2	CNTNAP3B SLIT3 CNTNAP3	8.52e-04	40	87	3	PF02210
Domain	Homeodomain-like	HOXA9 HOXA10 HOXD1 NKX2-4 TLX3 HMX1 CUX1	9.11e-04	332	87	7	IPR009057
Domain	LamG	CNTNAP3B SLIT3 CNTNAP3	1.13e-03	44	87	3	SM00282
Domain	Ald_DH_CS_GLU	ALDH1A2 ALDH1A1	2.47e-03	16	87	2	IPR029510
Domain	Laminin_G	CNTNAP3B SLIT3 CNTNAP3	2.50e-03	58	87	3	IPR001791
Domain	Ald_DH_CS_CYS	ALDH1A2 ALDH1A1	2.79e-03	17	87	2	IPR016160
Domain	ALDEHYDE_DEHYDR_GLU	ALDH1A2 ALDH1A1	3.13e-03	18	87	2	PS00687
Domain	ALDEHYDE_DEHYDR_CYS	ALDH1A2 ALDH1A1	3.13e-03	18	87	2	PS00070
Domain	Ald_DH_C	ALDH1A2 ALDH1A1	3.48e-03	19	87	2	IPR016163
Domain	Ald_DH_N	ALDH1A2 ALDH1A1	3.48e-03	19	87	2	IPR016162
Domain	Ald_DH/histidinol_DH	ALDH1A2 ALDH1A1	3.48e-03	19	87	2	IPR016161
Domain	-	ALDH1A2 ALDH1A1	3.48e-03	19	87	2	3.40.605.10
Domain	Aldedh	ALDH1A2 ALDH1A1	3.48e-03	19	87	2	PF00171
Domain	Aldehyde_DH_dom	ALDH1A2 ALDH1A1	3.48e-03	19	87	2	IPR015590
Domain	-	ALDH1A2 ALDH1A1	3.48e-03	19	87	2	3.40.309.10
Domain	MFS_dom	SLC2A8 SPNS2 SLC29A1 SLC16A10	3.56e-03	134	87	4	IPR020846
Domain	FA58C	CNTNAP3B CNTNAP3	4.25e-03	21	87	2	SM00231
Domain	FA58C_3	CNTNAP3B CNTNAP3	4.25e-03	21	87	2	PS50022
Domain	FA58C_1	CNTNAP3B CNTNAP3	4.25e-03	21	87	2	PS01285
Domain	FA58C_2	CNTNAP3B CNTNAP3	4.25e-03	21	87	2	PS01286
Domain	EGF_3	CNTNAP3B HMCN2 SLIT3 CNTNAP3 VWA2	4.84e-03	235	87	5	PS50026
Domain	F5_F8_type_C	CNTNAP3B CNTNAP3	5.54e-03	24	87	2	PF00754
Domain	FA58C	CNTNAP3B CNTNAP3	5.54e-03	24	87	2	IPR000421
Pathway	REACTOME_SIGNALING_BY_RETINOIC_ACID	ALDH1A2 PDK1 PDK2 PDK3 ALDH1A1	1.39e-06	43	64	5	M27443
Pathway	REACTOME_SIGNALING_BY_RETINOIC_ACID	ALDH1A2 PDK1 PDK2 PDK3 ALDH1A1	2.69e-06	49	64	5	MM15186
Pathway	REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX	PDK1 PDK2 PDK3	3.91e-05	15	64	3	MM14820
Pathway	REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX	PDK1 PDK2 PDK3	3.91e-05	15	64	3	M716
Pathway	WP_TCA_CYCLE	PDK1 PDK2 PDK3	3.66e-04	31	64	3	MM15856
Pathway	REACTOME_REGULATION_OF_PYRUVATE_METABOLISM	PDK1 PDK2 PDK3	4.42e-04	33	64	3	M48274
Pathway	REACTOME_REGULATION_OF_PYRUVATE_METABOLISM	PDK1 PDK2 PDK3	4.42e-04	33	64	3	MM17246
Pubmed	Tissue-specific kinase expression and activity regulate flux through the pyruvate dehydrogenase complex.	PDK1 PDK2 PDK3	6.25e-08	4	88	3	30482839
Pubmed	Differing roles of pyruvate dehydrogenase kinases during mouse oocyte maturation.	PDK1 PDK2 PDK3	6.25e-08	4	88	3	25991547
Pubmed	Diversity of the pyruvate dehydrogenase kinase gene family in humans.	PDK1 PDK2 PDK3	6.25e-08	4	88	3	7499431
Pubmed	Impact of cytosine methylation on DNA binding specificities of human transcription factors.	HOXA9 HOXA10 HOXD1 ZIC5 TLX3 SOX18 GATA5 HMX1 HSF4 CUX1 TBX6	1.34e-07	544	88	11	28473536
Pubmed	Regulation of pyruvate dehydrogenase activity through phosphorylation at multiple sites.	PDK1 PDK2 PDK3	1.56e-07	5	88	3	11485553
Pubmed	Interaction between the individual isoenzymes of pyruvate dehydrogenase kinase and the inner lipoyl-bearing domain of transacetylase component of pyruvate dehydrogenase complex.	PDK1 PDK2 PDK3	1.56e-07	5	88	3	11978179
Pubmed	Site specificity of four pyruvate dehydrogenase kinase isoenzymes toward the three phosphorylation sites of human pyruvate dehydrogenase.	PDK1 PDK2 PDK3	1.56e-07	5	88	3	11486000
Pubmed	BCKDK regulates the TCA cycle through PDC in the absence of PDK family during embryonic development.	PDK1 PDK2 PDK3	3.11e-07	6	88	3	33773101
Pubmed	Strain background effects and genetic modifiers of hearing in mice.	CDH23 ADGRV1 ATP2B2	2.55e-06	11	88	3	16579977
Pubmed	A census of human transcription factors: function, expression and evolution.	HOXA9 HOXD1 KLF1 NKX2-4 ZNF335 TLX3 ETS1 SOX18 GATA5 HMX1 HSF4 TBX6	3.11e-06	908	88	12	19274049
Pubmed	Recent advances in mechanisms regulating glucose oxidation at the level of the pyruvate dehydrogenase complex by PDKs.	PDK1 PDK2 PDK3	3.39e-06	12	88	3	12676647
Pubmed	The critical role of ASD-related gene CNTNAP3 in regulating synaptic development and social behavior in mice.	CNTNAP3B CNTNAP3	6.33e-06	2	88	2	31150793
Pubmed	Hearing loss associated with the modifier of deaf waddler (mdfw) locus corresponds with age-related hearing loss in 12 inbred strains of mice.	CDH23 ATP2B2	6.33e-06	2	88	2	11423214
Pubmed	Raldh1 promotes adiposity during adolescence independently of retinal signaling.	ALDH1A2 ALDH1A1	6.33e-06	2	88	2	29095919
Pubmed	Pyruvate dehydrogenase kinase 1 and 2 deficiency reduces high-fat diet-induced hypertrophic obesity and inhibits the differentiation of preadipocytes into mature adipocytes.	PDK1 PDK2	6.33e-06	2	88	2	34552205
Pubmed	mdfw: a deafness susceptibility locus that interacts with deaf waddler (dfw).	CDH23 ATP2B2	6.33e-06	2	88	2	9325047
Pubmed	Loss of expression of the Hoxa-9 homeobox gene impairs the proliferation and repopulating ability of hematopoietic stem cells.	HOXA9 HOXA10	6.33e-06	2	88	2	16091451
Pubmed	Overexpression of pyruvate dehydrogenase kinase supports dichloroacetate as a candidate for cutaneous melanoma therapy.	PDK1 PDK2	6.33e-06	2	88	2	25976231
Pubmed	A new Atp2b2 deafwaddler allele, dfw(i5), interacts strongly with Cdh23 and other auditory modifiers.	CDH23 ATP2B2	6.33e-06	2	88	2	23792079
Pubmed	Caspr3-Deficient Mice Exhibit Low Motor Learning during the Early Phase of the Accelerated Rotarod Task.	CNTNAP3B CNTNAP3	6.33e-06	2	88	2	26807827
Pubmed	PDH activation during in vitro muscle contractions in PDH kinase 2 knockout mice: effect of PDH kinase 1 compensation.	PDK1 PDK2	6.33e-06	2	88	2	21411764
Pubmed	Modification of human hearing loss by plasma-membrane calcium pump PMCA2.	CDH23 ATP2B2	6.33e-06	2	88	2	15829536
Pubmed	Overexpression of PDK2 and PDK3 reflects poor prognosis in acute myeloid leukemia.	PDK2 PDK3	6.33e-06	2	88	2	30578412
Pubmed	An unexpected role for a Wnt-inhibitor: Dickkopf-1 triggers a novel cancer survival mechanism through modulation of aldehyde-dehydrogenase-1 activity.	DKK1 ALDH1A1	6.33e-06	2	88	2	24577091
Pubmed	A long-range interactive DNA methylation marker panel for the promoters of HOXA9 and HOXA10 predicts survival in breast cancer patients.	HOXA9 HOXA10	6.33e-06	2	88	2	28748001
Pubmed	[Expression Level of Protein Kinase D in Oral Squamous Cell Carcinoma with Diverse Differentiation].	PDK1 PDK2	6.33e-06	2	88	2	33236596
Pubmed	A functional study of plasma-membrane calcium-pump isoform 2 mutants causing digenic deafness.	CDH23 ATP2B2	6.33e-06	2	88	2	17234811
Pubmed	Marked differences between two isoforms of human pyruvate dehydrogenase kinase.	PDK2 PDK3	6.33e-06	2	88	2	10748134
Pubmed	Cryptorchidism and homeotic transformations of spinal nerves and vertebrae in Hoxa-10 mutant mice.	HOXA9 HOXA10	6.33e-06	2	88	2	7667266
Pubmed	The Mass1frings mutation underlies early onset hearing impairment in BUB/BnJ mice, a model for the auditory pathology of Usher syndrome IIC.	CDH23 ADGRV1	6.33e-06	2	88	2	15820310
Pubmed	Raldh2 expression in optic vesicle generates a retinoic acid signal needed for invagination of retina during optic cup formation.	ALDH1A2 ALDH1A1	6.33e-06	2	88	2	15366004
Pubmed	Altered transmission of HOX and apoptotic SNPs identify a potential common pathway for clubfoot.	HOXA9 HOXA10 HOXD1	6.97e-06	15	88	3	19938081
Pubmed	New insights into the role of Jmjd3 and Utx in axial skeletal formation in mice.	HOXA9 HOXA10 ALDH1A2 HOXD1	8.06e-06	50	88	4	28188179
Pubmed	Multiple enhancers regulate Hoxd genes and the Hotdog LncRNA during cecum budding.	HOXA9 HOXA10 HOXD1	1.04e-05	17	88	3	24075990
Pubmed	A beta-catenin gradient links the clock and wavefront systems in mouse embryo segmentation.	ALDH1A2 DKK1 TBX6	1.24e-05	18	88	3	18157121
Pubmed	Switching axial progenitors from producing trunk to tail tissues in vertebrate embryos.	HOXA9 HOXA10 ALDH1A2	1.47e-05	19	88	3	23763947
Pubmed	A retinoic acid-dependent network in the foregut controls formation of the mouse lung primordium.	ALDH1A2 DKK1	1.90e-05	3	88	2	20484817
Pubmed	Distinct structural mechanisms for inhibition of pyruvate dehydrogenase kinase isoforms by AZD7545, dichloroacetate, and radicicol.	PDK1 PDK3	1.90e-05	3	88	2	17683942
Pubmed	RALDH3, a retinaldehyde dehydrogenase that generates retinoic acid, is expressed in the ventral retina, otic vesicle and olfactory pit during mouse development.	ALDH1A2 ALDH1A1	1.90e-05	3	88	2	11025231
Pubmed	Effect of four genes (ALDH1, NRF1, JAM and KBL) on proliferation arrest in a non-small cell bronchopulmonary cancer line.	GCAT ALDH1A1	1.90e-05	3	88	2	12174908
Pubmed	Consequences of lineage-specific gene loss on functional evolution of surviving paralogs: ALDH1A and retinoic acid signaling in vertebrate genomes.	ALDH1A2 ALDH1A1	1.90e-05	3	88	2	19478994
Pubmed	Retinaldehyde dehydrogenase 2 (RALDH2)- independent patterns of retinoic acid synthesis in the mouse embryo.	ALDH1A2 ALDH1A1	1.90e-05	3	88	2	12454286
Pubmed	Setbp1 promotes the self-renewal of murine myeloid progenitors via activation of Hoxa9 and Hoxa10.	HOXA9 HOXA10	1.90e-05	3	88	2	22566606
Pubmed	Sexually dimorphic sterility phenotypes in Hoxa10-deficient mice.	HOXA9 HOXA10	1.90e-05	3	88	2	7700356
Pubmed	Dendritic Cell Expression of Retinal Aldehyde Dehydrogenase-2 Controls Graft-versus-Host Disease Lethality.	ALDH1A2 ALDH1A1	1.90e-05	3	88	2	30885956
Pubmed	Structural and kinetic features of aldehyde dehydrogenase 1A (ALDH1A) subfamily members, cancer stem cell markers active in retinoic acid biosynthesis.	ALDH1A2 ALDH1A1	1.90e-05	3	88	2	31923393
Pubmed	Retinoic acid signaling mediates peripheral cone photoreceptor survival in a mouse model of retina degeneration.	ALDH1A2 ALDH1A1	1.90e-05	3	88	2	35315776
Pubmed	Comprehensive Landscape of HOXA2, HOXA9, and HOXA10 as Potential Biomarkers for Predicting Progression and Prognosis in Prostate Cancer.	HOXA9 HOXA10	1.90e-05	3	88	2	35372588
Pubmed	Changing patterns of the retinoic acid system in the developing retina.	ALDH1A2 ALDH1A1	1.90e-05	3	88	2	8393814
Pubmed	The expression pattern of the murine Hoxa-10 gene and the sequence recognition of its homeodomain reveal specific properties of Abdominal B-like genes.	HOXA9 HOXA10	1.90e-05	3	88	2	7862151
Pubmed	Differential expression of retinoic acid-synthesizing (RALDH) enzymes during fetal development and organ differentiation in the mouse.	ALDH1A2 ALDH1A1	1.90e-05	3	88	2	11744377
Pubmed	HIF1α modulates cell fate reprogramming through early glycolytic shift and upregulation of PDK1-3 and PKM2.	PDK1 PDK3	1.90e-05	3	88	2	24123565
Pubmed	Identification of three novel non-classical cadherin genes through comprehensive analysis of large cDNAs.	DCHS1 CDH23	1.90e-05	3	88	2	11597768
Pubmed	TLX homeodomain oncogenes mediate T cell maturation arrest in T-ALL via interaction with ETS1 and suppression of TCRα gene expression.	TLX3 ETS1	1.90e-05	3	88	2	22516263
Pubmed	Distinct functions for Aldh1 and Raldh2 in the control of ligand production for embryonic retinoid signaling pathways.	ALDH1A2 ALDH1A1	1.90e-05	3	88	2	10570467
Pubmed	Identification of active retinaldehyde dehydrogenase isoforms in the postnatal human eye.	ALDH1A2 ALDH1A1	1.90e-05	3	88	2	25793304
Pubmed	Concerted action of aldehyde dehydrogenases influences depot-specific fat formation.	ALDH1A2 ALDH1A1	1.90e-05	3	88	2	21436255
Pubmed	Sources of all-trans retinal oxidation independent of the aldehyde dehydrogenase 1A isozymes exist in the postnatal testis†.	ALDH1A2 ALDH1A1	1.90e-05	3	88	2	30247516
Pubmed	Quantitative analysis of SOD2, ALDH1A1 and MGST1 messenger ribonucleic acid in anterior lens epithelium of patients with pseudoexfoliation syndrome.	MGST1 ALDH1A1	1.90e-05	3	88	2	23805041
Pubmed	The zinc finger proteins ZXDA and ZXDC form a complex that binds CIITA and regulates MHC II gene transcription.	CIITA ZXDA	1.90e-05	3	88	2	17493635
Pubmed	The so-called "testis-specific aldehyde dehydrogenase" corresponds to type 2 retinaldehyde dehydrogenase in the mouse.	ALDH1A2 ALDH1A1	1.90e-05	3	88	2	12610736
Pubmed	Complementary domains of retinoic acid production and degradation in the early chick embryo.	ALDH1A2 ALDH1A1	1.90e-05	3	88	2	10588879
Pubmed	Pyruvate dehydrogenase activation and kinase expression in human skeletal muscle during fasting.	PDK1 PDK3	1.90e-05	3	88	2	14966024
Pubmed	Evolutionarily conserved requirement of Cdx for post-occipital tissue emergence.	HOXA9 ALDH1A2 TBX6	2.01e-05	21	88	3	22675207
Pubmed	Retinoic acid in the formation of the dorsoventral retina and its central projections.	ALDH1A2 ALDH1A1	3.79e-05	4	88	2	10837133
Pubmed	Dynamic expression of the retinoic acid-synthesizing enzyme retinol dehydrogenase 10 (rdh10) in the developing mouse brain and sensory organs.	ALDH1A2 ALDH1A1	3.79e-05	4	88	2	18399539
Pubmed	Interaction of protocadherin-15 with the scaffold protein whirlin supports its anchoring of hair-bundle lateral links in cochlear hair cells.	CDH23 ADGRV1	3.79e-05	4	88	2	33009420
Pubmed	KDM4A Coactivates E2F1 to Regulate the PDK-Dependent Metabolic Switch between Mitochondrial Oxidation and Glycolysis.	PDK1 PDK3	3.79e-05	4	88	2	27626669
Pubmed	Astrocytes as a regulated source of retinoic acid for the brain.	ALDH1A2 ALDH1A1	3.79e-05	4	88	2	22930583
Pubmed	MGMT-independent temozolomide resistance in pediatric glioblastoma cells associated with a PI3-kinase-mediated HOX/stem cell gene signature.	HOXA9 HOXA10	3.79e-05	4	88	2	20935218
Pubmed	Global Deletion of ALDH1A1 and ALDH1A2 Genes Does Not Affect Viability but Blocks Spermatogenesis.	ALDH1A2 ALDH1A1	3.79e-05	4	88	2	35574006
Pubmed	Characterization of cardiac-resident progenitor cells expressing high aldehyde dehydrogenase activity.	ALDH1A2 ALDH1A1	3.79e-05	4	88	2	23484127
Pubmed	Three members of the human pyruvate dehydrogenase kinase gene family are direct targets of the peroxisome proliferator-activated receptor beta/delta.	PDK2 PDK3	3.79e-05	4	88	2	17669420
Pubmed	A conserved Hox axis in the mouse and human female reproductive system: late establishment and persistent adult expression of the Hoxa cluster genes.	HOXA9 HOXA10	3.79e-05	4	88	2	9408238
Pubmed	Two functionally redundant sources of retinoic acid secure spermatogonia differentiation in the seminiferous epithelium.	ALDH1A2 ALDH1A1	3.79e-05	4	88	2	30487180
Pubmed	Down-regulation of homeobox genes MEIS1 and HOXA in MLL-rearranged acute leukemia impairs engraftment and reduces proliferation.	HOXA9 HOXA10	3.79e-05	4	88	2	21518888
Pubmed	Evidence that Hoxa expression domains are evolutionarily transposed in spinal ganglia, and are established by forward spreading in paraxial mesoderm.	HOXA9 HOXA10	3.79e-05	4	88	2	10354475
Pubmed	cis-Retinol/androgen dehydrogenase, isozyme 3 (CRAD3): a short-chain dehydrogenase active in a reconstituted path of 9-cis-retinoic acid biosynthesis in intact cells.	ALDH1A2 ALDH1A1	3.79e-05	4	88	2	11876656
Pubmed	The Mll partial tandem duplication: differential, tissue-specific activity in the presence or absence of the wild-type allele.	HOXA9 HOXA10	3.79e-05	4	88	2	18617636
Pubmed	Retinoic acid induces Sertoli cell paracrine signals for spermatogonia differentiation but cell autonomously drives spermatocyte meiosis.	ALDH1A2 ALDH1A1	3.79e-05	4	88	2	23012458
Pubmed	Formation of functional heterodimers by isozymes 1 and 2 of pyruvate dehydrogenase kinase.	PDK1 PDK2	3.79e-05	4	88	2	12573248
Pubmed	Role for a novel Usher protein complex in hair cell synaptic maturation.	CDH23 ADGRV1	3.79e-05	4	88	2	22363448
Pubmed	Compartment-dependent activities of Wnt3a/β-catenin signaling during vertebrate axial extension.	HOXA9 ALDH1A2 TBX6	4.38e-05	27	88	3	25152336
Pubmed	R-spondin signalling is essential for the maintenance and differentiation of mouse nephron progenitors.	ALDH1A2 ZNRF3 LGR6	6.05e-05	30	88	3	32324134
Pubmed	Novel retinoic acid generating activities in the neural tube and heart identified by conditional rescue of Raldh2 null mutant mice.	ALDH1A2 ALDH1A1	6.30e-05	5	88	2	11959834
Pubmed	Inhibitory co-transmission from midbrain dopamine neurons relies on presynaptic GABA uptake.	SLC6A1 ALDH1A1	6.30e-05	5	88	2	35443174
Pubmed	Cathepsin E: a novel target for regulation by class II transactivator.	CIITA CTSE	6.30e-05	5	88	2	15100295
Pubmed	Retinoic acid signaling is directly activated in cardiomyocytes and protects mouse hearts from apoptosis after myocardial infarction.	ALDH1A2 ALDH1A1	6.30e-05	5	88	2	34623260
Pubmed	PRC2-Associated Chromatin Contacts in the Developing Limb Reveal a Possible Mechanism for the Atypical Role of PRC2 in HoxA Gene Expression.	HOXA9 HOXA10	6.30e-05	5	88	2	31204170
Pubmed	LGR6 is a high affinity receptor of R-spondins and potentially functions as a tumor suppressor.	DKK1 LGR6	6.30e-05	5	88	2	22615920
Pubmed	Ndrg2 regulates vertebral specification in differentiating somites.	HOXA9 HOXA10 ALDH1A2	7.36e-05	32	88	3	22819676
Pubmed	Regulation of prefrontal patterning and connectivity by retinoic acid.	ALDH1A2 ALDH1A1 CUX1	8.85e-05	34	88	3	34599305
Pubmed	Physical and functional interactions between hematopoietic cell-specific ETS transcription factors and homeodomain proteins.	HOXA10 ETS1	9.43e-05	6	88	2	18692240
Pubmed	Targeted disruption of Aldh1a1 (Raldh1) provides evidence for a complex mechanism of retinoic acid synthesis in the developing retina.	ALDH1A2 ALDH1A1	9.43e-05	6	88	2	12808103
Pubmed	Retinoic acid regulates olfactory progenitor cell fate and differentiation.	ALDH1A2 ALDH1A1	9.43e-05	6	88	2	23829703
Pubmed	Dynamic expression of retinoic acid-synthesizing and -metabolizing enzymes in the developing mouse inner ear.	ALDH1A2 ALDH1A1	9.43e-05	6	88	2	16615129
Pubmed	In trans neuregulin3-Caspr3 interaction controls DA axonal bassoon cluster development.	CNTNAP3B CNTNAP3	9.43e-05	6	88	2	34143959
Pubmed	Cardiac T-box factor Tbx20 directly interacts with Nkx2-5, GATA4, and GATA5 in regulation of gene expression in the developing heart.	ALDH1A2 GATA5	9.43e-05	6	88	2	14550786
Pubmed	Retinoic acid promotes the generation of pancreatic endocrine progenitor cells and their further differentiation into beta-cells.	ALDH1A2 ALDH1A1	9.43e-05	6	88	2	18665267
Pubmed	A retinoic acid synthesizing enzyme in ventral retina and telencephalon of the embryonic mouse.	ALDH1A2 ALDH1A1	9.43e-05	6	88	2	10906479
Interaction	FAM168B interactions	PRR35 UBAP2 TLX3 SAMD7 HSF4	4.55e-06	58	85	5	int:FAM168B
GeneFamily	HOXL subclass homeoboxes	HOXA9 HOXA10 HOXD1	5.88e-04	52	57	3	518
GeneFamily	NKL subclass homeoboxes and pseudogenes	NKX2-4 TLX3 HMX1	1.23e-03	67	57	3	519
GeneFamily	Cadherin related	DCHS1 CDH23	1.29e-03	17	57	2	24
GeneFamily	Aldehyde dehydrogenases	ALDH1A2 ALDH1A1	1.61e-03	19	57	2	398
GeneFamily	Solute carriers	SLC5A5 SLC6A1 SLC2A8 SLC29A1 SLC16A10	8.01e-03	395	57	5	752
Coexpression	MEISSNER_NPC_HCP_WITH_H3K4ME2_AND_H3K27ME3	ALDH1A2 ADRA2C HOXD1 NKX2-4 TLX3 FOXB2 SOX18 HMX1 VWA2 ATP2B2	2.84e-07	350	88	10	M1949
Coexpression	MEISSNER_NPC_HCP_WITH_H3K4ME2_AND_H3K27ME3	ALDH1A2 ADRA2C HOXD1 NKX2-4 TLX3 FOXB2 SOX18 HMX1 VWA2 ATP2B2	3.41e-07	357	88	10	MM828
Coexpression	MEISSNER_BRAIN_HCP_WITH_H3K27ME3	SLC5A5 HOXA10 HOXD1 NKX2-4 TLX3 FOXB2 GATA5 LGR6 HMX1	3.42e-07	272	88	9	M1938
Coexpression	MEISSNER_BRAIN_HCP_WITH_H3K27ME3	SLC5A5 HOXA10 HOXD1 NKX2-4 TLX3 FOXB2 GATA5 LGR6 HMX1	4.62e-07	282	88	9	MM822
Coexpression	MIKKELSEN_NPC_HCP_WITH_H3K27ME3	HOXA9 ALDH1A2 ADRA2C TLX3 FOXB2 SOX18 GATA5 VWA2 ATP2B2	2.45e-06	345	88	9	M2009
Coexpression	MIKKELSEN_NPC_HCP_WITH_H3K27ME3	HOXA9 ALDH1A2 ADRA2C TLX3 FOXB2 SOX18 GATA5 VWA2 ATP2B2	2.57e-06	347	88	9	MM860
Coexpression	GSE28737_WT_VS_BCL6_KO_MARGINAL_ZONE_BCELL_UP	MTHFSD NAALADL1 ADAT3 KLF1 NKX2-4 PIP5KL1 CTSE	4.94e-06	199	88	7	M9345
Coexpression	GSE9946_IMMATURE_VS_LISTERIA_INF_MATURE_DC_DN	HOXA9 RBM15 MGST1 FAM169A AHDC1 ADCYAP1	5.87e-06	133	88	6	M420
Coexpression	CHIANG_LIVER_CANCER_SUBCLASS_INTERFERON_DN	ZNF703 ZNRF3 FAM169A SLC16A10	2.84e-05	52	88	4	M14353
Coexpression	SHIN_B_CELL_LYMPHOMA_CLUSTER_5	HOXA9 HOXD1 CIITA	2.88e-05	18	88	3	M1388
Coexpression	HOOI_ST7_TARGETS_DN	PDK1 PDK3 CNTNAP3 WNK3 FAM131B	4.37e-05	115	88	5	M14801
Coexpression	BENPORATH_EED_TARGETS	SLC6A1 HOXA9 HOXA10 MOXD1 RIPK3 DKK1 HOXD1 ZNF335 TLX3 CDH23 HSF4 ADCYAP1 DUOXA2	5.13e-05	1059	88	13	M7617
Coexpression	BENPORATH_ES_WITH_H3K27ME3	SLC6A1 HOXA9 HOXA10 RIPK3 DKK1 HOXD1 SLIT3 TLX3 CDH23 CSMD2 HSF4 ADCYAP1 DUOXA2	8.64e-05	1115	88	13	M10371
Coexpression	SHIN_B_CELL_LYMPHOMA_CLUSTER_5	HOXA9 HOXD1 CIITA	1.25e-04	29	88	3	MM586
Coexpression	DESCARTES_ORGANOGENESIS_INHIBITORY_INTERNEURONS	SLC6A1 CNTNAP3B CNTNAP3	1.39e-04	30	88	3	MM3663
Coexpression	BONOME_OVARIAN_CANCER_SURVIVAL_OPTIMAL_DEBULKING	HOXA9 HOXA10 HOXD1 CILP CUX1 SLC16A10	1.50e-04	237	88	6	M7068
Coexpression	MIKKELSEN_MEF_HCP_WITH_H3K27ME3	SLC5A5 SLC6A1 ADRA2C TLX3 SOX18 GATA5 HMX1 ATP2B2 ADCYAP1	1.66e-04	591	88	9	M2019
Coexpression	MIKKELSEN_MEF_HCP_WITH_H3K27ME3	SLC5A5 SLC6A1 ADRA2C TLX3 SOX18 GATA5 HMX1 ATP2B2 ADCYAP1	1.89e-04	601	88	9	MM866
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Sst\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	SLC5A5 SLC6A1 MOXD1 CNTNAP3 DCHS1 SLC29A1	8.13e-07	161	88	6	dccb61d5e17a8f1c6d1fc146ee389f567659a0f0
ToppCell	368C-Myeloid-Macrophage-SPP1+_Macrophage_2\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	UBL7 ZNF703 ZNF335 VSIG10L MYO18A PRX	1.08e-06	169	88	6	ea600c63cf9572bc4b3cad6392f67bd0d92c7fc9
ToppCell	P15-Mesenchymal-mesenchymal_fibroblast-mesenchymal_progenitor_cell\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	RBM15 CILP CIITA LGR6 ADGRV1 SLC16A10	1.12e-06	170	88	6	ba4ba66b624089ed50a9083176386c7941b4c7a3
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CNTNAP3B MGST1 SLIT3 CNTNAP3 LGR6 VWA2	1.37e-06	176	88	6	72a2a01618ce836bc843395d5095e9090759b4a6
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_FAM95C\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CNTNAP3B MGST1 SLIT3 CNTNAP3 LGR6 VWA2	1.46e-06	178	88	6	431e7557b8e8764e16e9e48368ce6bfa3c61561a
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CNTNAP3B MGST1 SLIT3 CNTNAP3 LGR6 VWA2	1.56e-06	180	88	6	e8841ef1239f9ee73ac4f4e11faca0742694f368
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CNTNAP3B MGST1 SLIT3 CNTNAP3 LGR6 VWA2	1.66e-06	182	88	6	05c167158815bf25d509df59ab386e1990712765
ToppCell	droplet-Marrow-nan-21m-Hematologic-erythroblast\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ALDH1A2 KLF1 ALDH1A1 CTSE SLC29A1 SLC16A10	1.88e-06	186	88	6	6e6998f5ccb1b2628048a21e8d3053e020569aba
ToppCell	droplet-Marrow-BM-30m-Hematologic-erythroblast\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ALDH1A2 KLF1 ALDH1A1 CTSE SLC29A1 SLC16A10	2.00e-06	188	88	6	f1a9d8ea174a4bef0fae8188e3bd96b7ac1a39bb
ToppCell	Megakaryocytic-erythropoietic-Erythro-cells-Basophilic_Erythroblast\|World / Lineage, cell class and subclass	HOXA9 HOXA10 KLF1 GCAT ALDH1A1 SLC29A1	2.40e-06	194	88	6	f054d78429364622d402ce1d9bf6ad13a1a1bf7e
ToppCell	3'_v3-bone_marrow-Hematopoietic_progenitors-HSC-MPP\|bone_marrow / Manually curated celltypes from each tissue	HOXA9 HOXA10 MGST1 GCAT SPNS2 SLC29A1	2.55e-06	196	88	6	2440201ff08a88d7e4d92dd6e9ff4d0e271605eb
ToppCell	Parenchymal-10x5prime-Endothelial-Endothelia_vascular-VE_systemic_arterial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	SLC6A1 CNTNAP3B ADRA2C CNTNAP3 SOX18 ATP2B2	2.63e-06	197	88	6	ad4a3b5da2190be9495382a2952991e1de9f190d
ToppCell	Striatum-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)\|Striatum / BrainAtlas - Mouse McCarroll V32	MOXD1 CILP PIP5KL1 HSF4 ADCYAP1	6.73e-06	133	88	5	d5326a6ccada5ae6d3e8f7d4a858c90050e23c5b
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L5_PT\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	SLC5A5 ZNF703 KCNG2 SLIT3 ADCYAP1	8.64e-06	140	88	5	7cc891d676555609add6fc7880735d948a2ad801
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L5_PT-L5_PT_VISp_Krt80\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	SLC5A5 ZNF703 KCNG2 PIP5KL1 ADCYAP1	8.95e-06	141	88	5	40ef6d792e11fe10963d64eb0b606b90556c1a70
ToppCell	P03-Hematopoietic-Erythroid\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	ADAT3 KLF1 CTSE PRX DUOXA2	9.91e-06	144	88	5	2ee6a834860eac7ed004f366ab4fc38c4b80c905
ToppCell	P03-Hematopoietic-Erythroid-enucleate_erythrocyte\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	ADAT3 KLF1 CTSE PRX DUOXA2	9.91e-06	144	88	5	9fa63904389f4d7163db22ea85ab721d8f6e8d99
ToppCell	Frontal_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	SLC6A1 MOXD1 PIP5KL1 CNTNAP3 HSF4	1.02e-05	145	88	5	8b13b576fd2e6e33ccb146860a91a53cee0cdd4d
ToppCell	facs-Marrow-KLS-18m-Lymphocytic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ETS1 SOX18 ADGRV1 ATP2B2 PRX	1.37e-05	154	88	5	37765512dfae557b9f6eb30a29463b93682a4404
ToppCell	wk_20-22-Hematologic-Myeloid-Mast\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	HOXA9 HOXA10 KLF1 ALDH1A1 ADCYAP1	1.97e-05	166	88	5	004ab6a1425d812c7ce572205875fd702d4a9659
ToppCell	10x5'-bone_marrow-Hematopoietic_progenitors-Progenitor_pre-Lymphocytic-T\|bone_marrow / Manually curated celltypes from each tissue	HOXA9 COL17A1 MGST1 GCAT SPNS2	1.97e-05	166	88	5	20f248d95c86eb52a1efe9abe73123fbe4206caf
ToppCell	368C-Myeloid-Macrophage-SPP1+_Macrophage_2\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	UBL7 VSIG10L MYO18A VARS2 PRX	2.15e-05	169	88	5	c6e5b179461996ced6c7621dc01cec00d401f4e8
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Sst\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	SLC5A5 SLC6A1 MOXD1 CNTNAP3 SLC29A1	2.21e-05	170	88	5	8ab67e2b6e30fdf9e9a2c02e31d4df34e751a3ed
ToppCell	3'_v3-lymph-node_spleen-Hematopoietic_progenitors-Progenitor_Erythro-Mega\|lymph-node_spleen / Manually curated celltypes from each tissue	HOXA9 KLF1 GCAT ALDH1A1 VWA2	2.27e-05	171	88	5	3ecd0a074344179c57eb2d9a857ba594904d00fa
ToppCell	droplet-Marrow-nan-24m-Hematologic-nan\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ALDH1A2 KLF1 ALDH1A1 CTSE SLC29A1	2.40e-05	173	88	5	35dc897e06f905419d44093a92170d2cec35dd51
ToppCell	droplet-Marrow-nan-24m-Hematologic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ALDH1A2 KLF1 ALDH1A1 CTSE SLC29A1	2.40e-05	173	88	5	37825d0dda028cf677ff6ff16ea58bff75cb25a7
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CNTNAP3B MGST1 SLIT3 CNTNAP3 VWA2	2.40e-05	173	88	5	95c723b09254ae7131fe5ba0841472502e83269b
ToppCell	3'_v3-lymph-node_spleen-Hematopoietic_progenitors\|lymph-node_spleen / Manually curated celltypes from each tissue	HOXA9 HOXA10 KLF1 GCAT VWA2	2.47e-05	174	88	5	6d9bdf4d28ff8ebb66ffd1ccdd6a4fe9440a83f3
ToppCell	3'_v3-lymph-node_spleen-Hematopoietic_progenitors-HSC-MPP\|lymph-node_spleen / Manually curated celltypes from each tissue	HOXA9 HOXA10 GCAT SPNS2 VWA2	2.61e-05	176	88	5	32ed5623b8809b9f1aaf7a42dff9807d9376e9c2
ToppCell	3'_v3-lymph-node_spleen-Hematopoietic_progenitors-Progenitor_MEMP\|lymph-node_spleen / Manually curated celltypes from each tissue	HOXA9 KLF1 GCAT ALDH1A1 VWA2	2.61e-05	176	88	5	23a8ec42ebd42c539865a12d09773af90f3f8848
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_FAM95C\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CNTNAP3B SLIT3 CNTNAP3 LGR6 VWA2	2.83e-05	179	88	5	f65889bf1e41396979cce44a5e63f49dea2bbd9b
ToppCell	368C-Lymphocytic-ILC-ILC-2\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	MTHFSD FPR1 ARMC5 VSIG10L ALDH1A1	2.90e-05	180	88	5	eb5a57604c7f2ad256c300085dbf5069d0ae1ad0
ToppCell	droplet-Kidney-nan-3m-Epithelial-Epcam____podocyte\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ALDH1A2 ADRA2C PIP5KL1 FAM169A DUOXA2	2.90e-05	180	88	5	35c73670da90cb6924e822a2426d13a675685f09
ToppCell	368C-Lymphocytic-ILC\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	MTHFSD FPR1 ARMC5 VSIG10L ALDH1A1	2.90e-05	180	88	5	ddba4dc3bbcfe4e4a22400be73bbc62d3ff27d3c
ToppCell	HSPCs-Erythroblasts\|World / Lineage and Cell class	ALDH1A2 KLF1 ALDH1A1 CTSE SLC16A10	2.98e-05	181	88	5	ce26f1accc8f69b7bc4b929073e975c887566c6a
ToppCell	Club-club-8\|World / Class top	ALDH1A2 MGST1 CILP ALDH1A1 LGR6	3.06e-05	182	88	5	8111d917e588008d947021460ddf8f1e7ae1337a
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_VWA2\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CNTNAP3B SLIT3 CNTNAP3 LGR6 VWA2	3.06e-05	182	88	5	72e65a23cd36085bc880087d3cae92395de918a1
ToppCell	hematopoetic_progenitors-CD34+_MEP_2\|World / Lineage and Cell class	HOXA9 NAALADL1 MGST1 ADCYAP1 DUOXA2	3.06e-05	182	88	5	a7e7aa10f14111a6c7ba22e0f1668dcaa124714d
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CNTNAP3B SLIT3 CNTNAP3 LGR6 VWA2	3.14e-05	183	88	5	65f2a5895d166189a095cf7ea9dda171f0419b08
ToppCell	droplet-Spleen-nan-21m-Hematologic-megakaryocyte-erythroid_progenitor_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCNG2 ALDH1A2 KLF1 ALDH1A1 CTSE	3.31e-05	185	88	5	239cc5184825b3cc98638d4aec0a1de8e508d76c
ToppCell	Adult-Endothelial-capillary_endothelial_cell_(Cap1)-D231\|Adult / Lineage, Cell type, age group and donor	SPNS2 ETS1 DCHS1 SOX18 PRX	3.31e-05	185	88	5	07f9f38f0739d7c830641723a38385550ac1ac92
ToppCell	droplet-Lung-nan-18m-Mesenchymal-pulmonary_interstitial_fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MOXD1 DCHS1 GATA5 LGR6 FAM131B	3.40e-05	186	88	5	b58db5abdd3e9f0214b198c3cbd09b0b3c321eab
ToppCell	(8)_CD34_progenitor\|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)	HOXA9 HOXA10 MGST1 KLF1 ALDH1A1	3.40e-05	186	88	5	943c604a7cd873faf510096d094100512ba2d6bc
ToppCell	10x5'-GI_small-bowel-Myeloid_Monocytic-Nonclassical_monocytes\|GI_small-bowel / Manually curated celltypes from each tissue	ZNF703 PDK2 GLB1L FPR1 CDH23	3.40e-05	186	88	5	a16ecf70271894a842925f232009e2623d16947e
ToppCell	facs-BAT-Fat-24m-Epithelial-Epcam+\|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MOXD1 ADAT3 COL17A1 LGR6 VWA2	3.40e-05	186	88	5	b18d7398279a2d42414318aeb70514fd402f5a0a
ToppCell	droplet-Lung-nan-18m-Mesenchymal-Myofibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MOXD1 DCHS1 GATA5 LGR6 FAM131B	3.40e-05	186	88	5	cd6502bbf9dce318fdbb4965d49df8951e5f795c
ToppCell	droplet-Spleen-SPLEEN-30m-Hematologic\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ALDH1A2 KLF1 ALDH1A1 CTSE SLC16A10	3.40e-05	186	88	5	ac6e32cf07f0f013101ca7aedae0c562857f182b
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_3\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SLC6A1 CILP SLIT3 LGR6 CSMD2	3.40e-05	186	88	5	4780af76237d7af2abbe2d8d5530cdf53e3ed0b7
ToppCell	droplet-Spleen-SPLEEN-30m-Hematologic-nan\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ALDH1A2 KLF1 ALDH1A1 CTSE SLC16A10	3.40e-05	186	88	5	7cdcf507a9a1349ed2cf62b79116367c3fc732dd
ToppCell	(8)_CD34_progenitor\|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)	HOXA9 HOXA10 MGST1 KLF1 ALDH1A1	3.40e-05	186	88	5	e69a986b8618effd61875fda528a2e44aab11868
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MGST1 ZNRF3 CECR2 VARS2 ADGRV1	3.40e-05	186	88	5	e83718fabb057100835d3357df407f283d23fe16
ToppCell	droplet-Lung-18m-Mesenchymal-myofibroblast-myofibroblast_cell-pulmonary_interstitial_myofibroblast\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MOXD1 DCHS1 GATA5 LGR6 FAM131B	3.48e-05	187	88	5	8bd635abdee5d5a12a3f7bf74eab4282e8e40741
ToppCell	Healthy-HSPC\|World / disease group, cell group and cell class	HOXA9 HOXA10 KLF1 GCAT ALDH1A1	3.48e-05	187	88	5	8cd9e5499e5c2b2321ecbcf780df37fe0f165ac9
ToppCell	droplet-Lung-18m-Mesenchymal-myofibroblast-myofibroblast_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MOXD1 DCHS1 GATA5 LGR6 FAM131B	3.48e-05	187	88	5	3cb8cd7f7a4306ff74d1f7f9964014008ec1c6a0
ToppCell	COVID_vent-Myeloid-Monocytic-SC_&_Eosinophil\|COVID_vent / Disease condition, Lineage, Cell class and subclass	HOXA9 HOXA10 KLF1 SPNS2 ALDH1A1	3.66e-05	189	88	5	2157a2d40613f7d5ce2e7dbd266df441e449cdaf
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L2-4_PVALB_C8orf4\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC6A1 CNTNAP3B ZNF703 CNTNAP3 ETS1	3.66e-05	189	88	5	99a13b1b669b0cd36e3096632351d9ade25d1173
ToppCell	droplet-Marrow-nan-24m-Hematologic-erythroblast\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ALDH1A2 KLF1 ALDH1A1 CTSE SLC29A1	3.66e-05	189	88	5	98ace332c3c046694c6ade47de8c8bf57ec51271
ToppCell	tumor_Lung-Fibroblasts-Mesothelial_cells\|Fibroblasts / Location, Cell class and cell subclass	CNTNAP3B ALDH1A2 COL17A1 CTSE ADCYAP1	3.76e-05	190	88	5	d82ab67735c1f365d4b0e02b5fa91c64cdc234da
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_3\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SLC6A1 CILP SLIT3 LGR6 CSMD2	3.76e-05	190	88	5	73d94fbae92029745989a8712eed8b99fd84c193
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC6A1 CNTNAP3B DKK1 CNTNAP3 ETS1	3.76e-05	190	88	5	8c9c230a509afaeee50644153974a5642b01a2b8
ToppCell	10x5'v1-week_17-19-Endothelial-stroma-proliferating_EC\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	HOXD1 SPNS2 CNTNAP3 DCHS1 SOX18	3.85e-05	191	88	5	dc9e5eb6aa31b8d79aeec33e59b9138dfb469a3b
ToppCell	facs-Large_Intestine-Distal-3m-Epithelial-intestinal_crypt_stem_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HOXA9 HOXA10 MGST1 ZNRF3 CTSE	3.85e-05	191	88	5	7411b253b16e4d472be0925dee49188f0fd6b0b5
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Myh8_Etv1_\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	SLC5A5 MOXD1 CNTNAP3 DCHS1	4.12e-05	97	88	4	f3c3fb260954f594a9ab8e1ac9a01115767cbc7a
ToppCell	myeloid-CD34+_Myeloblast\|myeloid / Lineage and Cell class	HOXA9 HOXA10 NAALADL1 GCAT SPNS2	4.15e-05	194	88	5	35549e63e8c167e6c4bd76e2d7863d95a3f3c3d5
ToppCell	myeloid-CD34+_Myeloblast\|World / Lineage and Cell class	HOXA10 NAALADL1 COL17A1 MGST1 SPNS2	4.15e-05	194	88	5	426d5cf04e21fec2fb6ea51abd85441b2dc5c94f
ToppCell	3'-Child09-12-SmallIntestine-Epithelial-epithelial_progenitor_cell\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HOXA9 ZNF703 MGST1 ZNRF3 ALDH1A1	4.15e-05	194	88	5	46e522ca59db545d1eb0c27cd4361f19d4f8f762
ToppCell	Adult-Endothelial\|Adult / Lineage, Cell type, age group and donor	CNTNAP3B SPNS2 ETS1 SOX18 PRX	4.15e-05	194	88	5	963b3fbee0575af8379baa397ace65949eaf34f7
ToppCell	distal-Hematologic-Nonclassical_Monocyte-2\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	VMP1 ZNF703 FPR1 CDH23 CUX1	4.25e-05	195	88	5	935461e849ca4d17627341b3ae5124d497793a91
ToppCell	Smart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic-neutrophil\|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	HMCN2 FPR1 CNTNAP3 ADGRV1 CSMD2	4.25e-05	195	88	5	d3755929ebbbf5e3afde44281e9056ddb614a291
ToppCell	Smart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic\|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	HMCN2 FPR1 CNTNAP3 ADGRV1 CSMD2	4.25e-05	195	88	5	19853c654ac64b3ae3bc99841c6cb29c8aaba85c
ToppCell	facs-Large_Intestine-Distal-18m-Epithelial-intestinal_crypt_stem_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HOXA9 HOXA10 MGST1 GCAT CTSE	4.25e-05	195	88	5	44ac99e33b20a377009b8fef16142050a3e1da51
ToppCell	PCW_07-8.5-Endothelial-Endothelial_immature-endo_immature_venous_(4)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	CNTNAP3B SPNS2 CNTNAP3 SOX18 ALDH1A1	4.25e-05	195	88	5	ca2cf2c10db1ad17aa0a2e30aa7079a7ad751ea6
ToppCell	10x_3'_v3-bone_marrow_(10x_3'_v3)-hematologic-hematopoietic_progenitor-erythroid_progenitor_cell\|bone_marrow_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	KLF1 ALDH1A1 CTSE SLC29A1 WNK3	4.36e-05	196	88	5	e994aa72b362a4f4930b94505a99c0a87e9b163c
ToppCell	3'-Pediatric_IBD-SmallIntestine-Epithelial-epithelial_progenitor_cell-Stem_cells\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HOXA9 ZNF703 MGST1 ZNRF3 ALDH1A1	4.36e-05	196	88	5	97324c9e93f833e1f218e81fb53066d44c6892df
ToppCell	10x5'-bone_marrow-Hematopoietic_Erythro-Mega\|bone_marrow / Manually curated celltypes from each tissue	KLF1 GCAT ALDH1A1 CTSE SLC29A1	4.36e-05	196	88	5	707eecbb2b14051fd843afa66035014ec59e6bd5
ToppCell	Fetal_29-31_weeks-Endothelial\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CNTNAP3B SPNS2 ETS1 SOX18 PRX	4.36e-05	196	88	5	3981f6c7487598f4f7ce4650ac0ac5bd41481d66
ToppCell	10x5'-bone_marrow-Hematopoietic_Erythro-Mega-Erythrocytic_early\|bone_marrow / Manually curated celltypes from each tissue	KLF1 GCAT ALDH1A1 CTSE SLC29A1	4.36e-05	196	88	5	507254c4c00e535fe01851431b5b74a5f15d9592
ToppCell	Endothelial\|World / Lineage, Cell type, age group and donor	CNTNAP3B SPNS2 ETS1 SOX18 PRX	4.36e-05	196	88	5	96c6d78482a130ce4e29f6629972a06d10d7530e
ToppCell	Endothelial-capillary_endothelial_cell_(Cap1)\|World / Lineage, Cell type, age group and donor	CNTNAP3B SPNS2 ETS1 SOX18 PRX	4.36e-05	196	88	5	0ce3ed27d2b9276390952652c17a8d6de13add36
ToppCell	erythropoietic\|World / Lineage and Cell class	KLF1 GCAT ALDH1A1 CTSE SLC29A1	4.46e-05	197	88	5	a52546cebc222050c970e04cec97e4f48ab8fe10
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Mesenchymal-immature_mesenchymal_cell-Mesoderm_1_(HAND1+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HOXA9 HOXA10 ZNF703 ALDH1A1 CSMD2	4.46e-05	197	88	5	2a90422ba400b951517603a916f34221056d0f3d
ToppCell	Fetal_29-31_weeks-Endothelial-capillary_endothelial_cell_(Cap1)\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CNTNAP3B SPNS2 ETS1 SOX18 PRX	4.46e-05	197	88	5	6a3c647af41fea923311562575a0d656fbc13cbe
ToppCell	10x_3'_v3-bone_marrow_(10x_3'_v3)-hematologic-hematopoietic_progenitor\|bone_marrow_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	KLF1 GCAT ALDH1A1 SLC29A1 WNK3	4.57e-05	198	88	5	d5996bd3756fcd4d5866006da2ecd923f0f25427
ToppCell	10x_3'_v3-bone_marrow_(10x_3'_v3)-hematologic\|bone_marrow_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	KLF1 GCAT ALDH1A1 SLC29A1 WNK3	4.57e-05	198	88	5	8be58e41ae7870d268e7ce5ab937769e2ecb60d9
ToppCell	3'_v3-bone_marrow-Hematopoietic_progenitors\|bone_marrow / Manually curated celltypes from each tissue	HOXA9 HOXA10 MGST1 KLF1 GCAT	4.57e-05	198	88	5	31e5b842d87f599b3d43447b8c11fcdb8f94d047
ToppCell	Tracheal-10x5prime-Endothelial-Endothelia_vascular-VE_alveolar_capillary_Car4_aerocyte\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	ALDH1A2 HOXD1 SPNS2 SOX18 PRX	4.57e-05	198	88	5	c77421898cc84ae2e8cc335087198dd05f13bfa5
ToppCell	COVID-19-COVID-19_Severe-Others-HSPC\|COVID-19_Severe / Disease, condition lineage and cell class	HOXA9 HOXA10 GCAT SPNS2 ALDH1A1	4.68e-05	199	88	5	25de67b6c9c8d6bb9a538e071a40ef865906c95d
ToppCell	Tracheal-10x3prime_v2-Endothelial-Endothelia_vascular-VE_systemic_arterial\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	CNTNAP3B ADRA2C CNTNAP3 SOX18 ATP2B2	4.68e-05	199	88	5	bd43a84e84d8acb8e1008b98a235cc5bd5f43586
ToppCell	severe-cDC\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	HOXA9 HOXA10 YIF1B MGST1 CIITA	4.79e-05	200	88	5	23e3d2fb86a71f62cca32640842fbba5dd163453
ToppCell	Epithelial-D_(Clara-Club_cells)\|World / shred on cell class and cell subclass (v4)	ALDH1A2 MGST1 ALDH1A1 ATP2B2	6.27e-05	108	88	4	93036a6a29fb2a0a5fd1ec35a1acff270d8fead9
ToppCell	Thalamus-Macroglia-OLIGODENDROCYTE-O1-Trf\|Thalamus / BrainAtlas - Mouse McCarroll V32	VMP1 PRR35 HOXD1 ADGRV1	7.22e-05	112	88	4	cb351e57c99aaaf9ae6c7ff7e8ce5375552b1639
ToppCell	Thalamus-Macroglia-OLIGODENDROCYTE-O1-Trf-Oligodendrocyte.Trf.Il33_(Il33)\|Thalamus / BrainAtlas - Mouse McCarroll V32	VMP1 PRR35 HOXD1 ADGRV1	7.22e-05	112	88	4	999b5eeed4305e1a1385aadbaf017b64f21c1ee0
ToppCell	Thalamus-Macroglia-OLIGODENDROCYTE-O1-Trf-Oligodendrocyte.Trf.Il33_(Il33)-\|Thalamus / BrainAtlas - Mouse McCarroll V32	VMP1 PRR35 HOXD1 ADGRV1	7.22e-05	112	88	4	004cd69b66c3b26b9a61f03279b48230da351574
ToppCell	Thalamus-Macroglia-OLIGODENDROCYTE-O1\|Thalamus / BrainAtlas - Mouse McCarroll V32	VMP1 PRR35 HOXD1 ADGRV1	7.22e-05	112	88	4	502e3f356f6e1c959bff0a39c98f33f863ce8265
ToppCell	Epithelial-Epithelial-D_(Clara-Club_cells)\|Epithelial / shred on cell class and cell subclass (v4)	ALDH1A2 MGST1 ALDH1A1 ATP2B2	1.04e-04	123	88	4	caa1576f1b5eb592d522be61c090ac444e277ac5
ToppCell	primary_visual_cortex-Non-neuronal-endothelial_cell-Endo-Endo_Cytl1\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	MGST1 ETS1 SOX18 VWA2	1.18e-04	127	88	4	eee8e4a83f7de46807440d202d46eee7dd722001
ToppCell	Entopeduncular-Macroglia-OLIGODENDROCYTE\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	PRR35 ADAT3 HOXD1 ADGRV1	1.29e-04	130	88	4	0a6b87635e650df431a88f2e6396abead84d901d
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L5_PT\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	SLC5A5 ZNF703 KCNG2 ADCYAP1	1.45e-04	134	88	4	cb676d5bbc468bd3ce1b6712d41c986ee9221ac5
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Crhr2_Efemp1\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	SLC5A5 MOXD1 CNTNAP3 DCHS1	1.53e-04	136	88	4	e3a2425ba5ef538dbacab1479e682837ae42a888
ToppCell	Substantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Th-Inhibitory_Neuron.Th.Aldh1a1_(SNc/VTA)\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	ALDH1A2 RIPK3 CIITA	1.86e-04	56	88	3	fedec1be5368a82a75f640e84809e4270dd57c85
Drug	VER-246608	PDK1 PDK2 PDK3	5.55e-07	5	88	3	ctd:C000602510
Drug	Lynestrenol [52-76-6]; Up 200; 14uM; HL60; HG-U133A	MTHFSD CILP CIITA PDK2 PDK3 ZNF335 TBX6	1.07e-05	195	88	7	2037_UP
Drug	Paromomycin sulfate [1263-89-4]; Down 200; 5.6uM; HL60; HT_HG-U133A	SLC5A5 HOXA10 MTHFSD SYNJ1 PDK3 ATP2B2 CUX1	1.22e-05	199	88	7	3017_DN
Disease	DEAFNESS, AUTOSOMAL RECESSIVE 12	CDH23 ATP2B2	8.20e-06	2	85	2	601386
Disease	Deafness, Autosomal Recessive 12	CDH23 ATP2B2	8.20e-06	2	85	2	C1832394
Disease	Autosomal recessive nonsyndromic hearing loss 12	CDH23 ATP2B2	8.20e-06	2	85	2	cv:C1832394
Disease	autosomal recessive nonsyndromic deafness 12 (is_implicated_in)	CDH23 ATP2B2	8.20e-06	2	85	2	DOID:0110467 (is_implicated_in)
Disease	Parkinsonism, Juvenile	ALDH1A2 SYNJ1 ALDH1A1	8.85e-05	30	85	3	C0752105
Disease	Thyroid Dyshormonogenesis 1	SLC5A5 DUOXA2	1.22e-04	6	85	2	C1848805
Disease	red blood cell density measurement	HOXA9 ALDH1A2 ZNRF3 CIITA KLF1 GATA5 ADGRV1 ADCYAP1 SLC16A10 TBX6	2.20e-04	880	85	10	EFO_0007978
Disease	autosomal recessive intellectual developmental disorder (implicated_via_orthology)	CNTNAP3B CNTNAP3	2.27e-04	8	85	2	DOID:0060308 (implicated_via_orthology)
Disease	total cholesterol measurement, response to escitalopram, response to citalopram	ALDH1A2 SLIT3	2.27e-04	8	85	2	EFO_0004574, EFO_0006329, EFO_0007871
Disease	acne	NAALADL1 ZNRF3 CIITA LGR6	4.77e-04	125	85	4	EFO_0003894
Disease	hematocrit	VMP1 ALDH1A2 UBAP2 RIPK3 ZNRF3 KLF1 SMG9 GATA5 ADGRV1 TBX6	6.52e-04	1011	85	10	EFO_0004348

Protein segments in the cluster

Peptide	Gene	Start	Entry
VFYGAPSPDGALGTR	ADAT3	306	Q96EY9
RGPPGVSGALATYAA	COL17A1	1226	Q9UMD9
YIDADGSGPLGPFLV	CNTNAP3	606	Q9BZ76
SRLPAPISAGLYGNF	CSMD2	996	Q7Z408
INILPGYGPTAGAAI	ALDH1A2	236	O94788
YVGLLGRAALDSPPG	CIITA	641	P33076
PPRGQYSAGAVAGLA	ADRA2C	41	P18825
GVPPAGIALLDAQGY	ADGRV1	2796	Q8WXG9
IVPGYGPTAGAAISS	ALDH1A1	221	P00352
PDPSGALVTGPALYG	ARMC5	536	Q96C12
FPPGRAASYGLTPAA	AHDC1	921	Q5TGY3
LGAGGSVLYSFQPPS	CDH23	161	Q9H251
FGPLRGSDPATLYGS	CECR2	656	Q9BXF3
IISLGLSFYHPPGEG	ATP2B2	116	Q01814
PAYSLEPRVGAGAGA	RBM15	341	Q96T37
VAGPNGYAILLAVPG	RBM15	851	Q96T37
TSRAVPLAGFGYGLP	PDK1	346	Q15118
GAGATLYREEGPPAT	DCHS1	3101	Q96JQ0
LSQFPPYGLGSAAAA	FOXB2	241	Q5VYV0
AALGPGGPYLQFLST	PIP5KL1	121	Q5T9C9
PGLGAPLGAAAAYRA	NKX2-4	36	Q9H2Z4
SGPAYDFPGVLGRAA	HOXD1	111	Q9GZZ0
AALPLASVGEYGASP	LGR6	701	Q9HBX8
GVSYSGVAPGAPLVS	HMCN2	416	Q8NDA2
YAASLGLGAGFPSIP	LSM14B	136	Q9BX40
FLGIGLLYSLSGPDP	MGST1	86	P10620
LFYGPAAPASGALPE	CUX1	481	Q13948
FDGILGLGYPSLAVG	CTSE	181	P14091
IPAAALAGYTGSGPI	ETS1	321	P14921
PFYVSLLLGLAAGPG	KCNG2	261	Q9UJ96
AAYFLLVGIPGLGPT	OR51D1	21	Q8NGF3
TYAGPSLLVLGPRGA	MYO18A	436	Q92614
PLLGFSGALAYPLAA	HMX1	316	Q9NP08
PGALSFAGLPSSRPY	HOXA9	116	P31269
GPVAGGLLSPARLYA	LRPPRC	46	P42704
LPYGLQSCGLFPTLG	HOXA10	71	P31260
ALGTSSGVPVPGYFR	HOXA10	201	P31260
SGGYTTGPGPLVSLL	GCAT	271	O75600
LIASPATGSYLGPAF	FAM131B	211	Q86XD5
ASGYSALEPPPLLGG	FAM131B	241	Q86XD5
TPLAGFGYGLPISRL	PDK2	321	Q15119
SPGLFSYLGPSLAAA	PRR35	216	P0CG20
SVYSSPAAAGLRFPG	ADCYAP1	21	P18509
FAAPLGRPVGTSYSA	GATA5	126	Q9BWX5
PAPLYGGLALLTTGA	DUOXA2	201	Q1HG44
YFPRTGLSVPAASGA	KLF1	181	Q13351
GLSVPAASGAPYGLL	KLF1	186	Q13351
PILGSVGDTFLYLPG	GLB1L	546	Q6UWU2
YASGAGLGSPAAPRL	C20orf144	66	Q9BQM9
PISLSNVGFVPLYGG	FAM169A	46	Q9Y6X4
GPALGLPGALTIYST	HSF4	461	Q9ULV5
AAGAGLPGLQRPLSY	FIGNL2	606	A6NMB9
PGSAVSAAPGILYPG	DKK1	56	O94907
ATGVYLAALPTPGGI	C2CD5	581	Q86YS7
YIDADGSGPLGPFLV	CNTNAP3B	606	Q96NU0
TLGYCGAVGLLPPGA	VARS2	951	Q5ST30
VAASGPGLAFLAYPE	SLC6A1	356	P30531
AGLAGPGPAGYSTAR	SYNJ1	1181	O43426
GLGIPFLYGSSVPAA	SAMD7	121	Q7Z3H4
ISGGTPAVSAGYLFL	FPR1	11	P21462
GFALGYSSPAIPSLQ	SLC2A8	41	Q9NY64
AGPGSSPLFSLLPGY	SMG9	446	Q9H0W8
FAIPLGSGLGYITGS	SPNS2	236	Q8IVW8
TRAAPLAGFGYGLPI	PDK3	316	Q15120
LFGLAGLLPASYTAP	SLC29A1	161	Q99808
SLPGGAPASGAAIYL	CILP	231	O75339
PLYLGGIPTSTGLSA	SLIT3	1276	O75094
GAQRAPGGLSYPAAS	YIF1B	51	Q5BJH7
GSTGPLASGAAPGYA	UBAP2	1046	Q5T6F2
AGGLAVPSLPTAGPY	ZNF703	556	Q9H7S9
EGFSYPPHVGLSLGT	MOXD1	281	Q6UVY6
SGEPGGTLGYLAPEL	RIPK3	176	Q9Y572
LPGVPGLFLACAYSG	SLC5A5	336	Q92911
PTGDLALRPGTVSGY	PRX	101	Q9BXM0
GAPLAADVYVGNLPG	MTHFSD	301	Q2M296
LSGNPGYVVGLPLAA	TCTN1	376	Q2MV58
APYLGGVGSAGTALL	VWA2	601	Q5GFL6
LGYSGAAGPRPITQS	UBL7	256	Q96S82
PYSAAFLELPHGSGG	TBX6	381	O95947
GAPGIISSPYAGAAG	PTBP3	296	O95758
ISSPYAGAAGFAPAI	PTBP3	301	O95758
YPSLPASFAGLGAPF	TLX3	56	O43711
GLLGSGPGVVLYLCP	ZXDA	256	P98168
STLFLGPHLYEGSGP	ZNRF3	731	Q9ULT6
AAPLAGLYYGTLGTP	SOX18	276	P35713
LLLPAVGPGHAGTYA	VSIG10L	456	Q86VR7
AYALPPGTTGTLPAA	SEC31A	966	O94979
LAPGPFGGTGYSVIT	ZNF335	871	Q9H4Z2
LGYSSVGTPVGAPLS	ZIC5	586	Q96T25
GLGTGLHTFLLYLGP	VMP1	126	Q96GC9
GLSLPSFPGPLSSYG	WNK3	1721	Q9BYP7
AFYLAGVPPLIGGAV	SLC16A10	451	Q8TF71
PVYGLVPSLGSLGAG	NAALADL1	496	Q9UQQ1
VPSLGSLGAGSDYAP	NAALADL1	501	Q9UQQ1