Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionubiquitin-like modifier activating enzyme activity

UBA1 UBA7

3.84e-0510192GO:0008641
GeneOntologyMolecularFunctionligase activity, forming carbon-sulfur bonds

UBA1 UBA7

6.88e-0441192GO:0016877
GeneOntologyCellularComponentU2-type prespliceosome

LUC7L LUC7L2

1.19e-0418192GO:0071004
GeneOntologyCellularComponentprespliceosome

LUC7L LUC7L2

1.19e-0418192GO:0071010
GeneOntologyCellularComponentU1 snRNP

LUC7L LUC7L2

4.06e-0433192GO:0005685
GeneOntologyCellularComponentspliceosomal snRNP complex

LUC7L LUC7L2

3.39e-0396192GO:0097525
GeneOntologyCellularComponentU2-type spliceosomal complex

LUC7L LUC7L2

3.46e-0397192GO:0005684
GeneOntologyCellularComponentsmall nuclear ribonucleoprotein complex

LUC7L LUC7L2

4.19e-03107192GO:0030532
GeneOntologyCellularComponentSm-like protein family complex

LUC7L LUC7L2

5.16e-03119192GO:0120114
DomainUBA_e1_C

UBA1 UBA7

2.94e-063192SM00985
DomainUb-activating_enz_E1_C

UBA1 UBA7

2.94e-063192IPR018965
DomainLUC7

LUC7L LUC7L2

2.94e-063192PF03194
DomainE1_4HB

UBA1 UBA7

2.94e-063192PF16191
DomainE1_FCCH

UBA1 UBA7

2.94e-063192PF16190
DomainLuc7-rel

LUC7L LUC7L2

2.94e-063192IPR004882
DomainE1_4HB

UBA1 UBA7

2.94e-063192IPR032420
DomainE1_FCCH

UBA1 UBA7

2.94e-063192IPR032418
DomainE1_UFD

UBA1 UBA7

2.94e-063192PF09358
DomainUBQ-activ_enz_E1

UBA1 UBA7

2.94e-063192IPR018075
DomainUBQ-activ_enz_E1_Cys_AS

UBA1 UBA7

5.88e-064192IPR033127
Domain-

UBA1 UBA7

5.88e-0641921.10.3240.10
DomainUBQ-activ_enz_E1_CS

UBA1 UBA7

5.88e-064192IPR018074
DomainUBIQUITIN_ACTIVAT_1

UBA1 UBA7

9.79e-065192PS00536
DomainUBIQUITIN_ACTIVAT_2

UBA1 UBA7

9.79e-065192PS00865
DomainUBA_E1_Cys

UBA1 UBA7

9.79e-065192IPR019572
DomainUBA_e1_thiolCys

UBA1 UBA7

9.79e-065192PF10585
DomainUBQ/SUMO-activ_enz_E1-like

UBA1 UBA7

1.47e-056192IPR000011
DomainThiF_NAD_FAD-bd

UBA1 UBA7

4.39e-0510192IPR000594
DomainThiF

UBA1 UBA7

4.39e-0510192PF00899
DomainCa/CaM-dep_Ca-dep_prot_Kinase

DCX ULK1

2.21e-0369192IPR020636
Domain-

UBA1 UBA7

1.26e-021691923.40.50.720
DomainNAD(P)-bd_dom

UBA1 UBA7

1.32e-02173192IPR016040
PathwayKEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_PTCH1_TO_HEDGEHOG_SIGNALING_PATHWAY

GLI2 WNT10B

3.66e-0429142M47372
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_SMO_TO_HEDGEHOG_SIGNALING_PATHWAY

GLI2 WNT10B

3.66e-0429142M47377
Pubmed

Functional analyses of human LUC7-like proteins involved in splicing regulation and myeloid neoplasms.

LUC7L LUC7L2

8.48e-07319233852859
Pubmed

Link between the ubiquitin conjugation system and the ISG15 conjugation system: ISG15 conjugation to the UbcH6 ubiquitin E2 enzyme.

UBA1 UBA7

2.82e-06519216428300
Pubmed

Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.

SCAF8 LUC7L LUC7L2 TOP2A TUBGCP2

1.24e-0558219520467437
Pubmed

R2TP/Prefoldin-like component RUVBL1/RUVBL2 directly interacts with ZNHIT2 to regulate assembly of U5 small nuclear ribonucleoprotein.

SCAF8 LUC7L LUC7L2 TUBGCP2

1.90e-0530019428561026
Pubmed

Topoisomerase IIA in adult NSCs regulates SVZ neurogenesis by transcriptional activation of Usp37.

DCX TOP2A

2.20e-051319236029179
Pubmed

Sonic hedgehog signaling is essential for hair development.

GLI2 WNT10B

2.96e-05151929768360
Pubmed

MARVELD1 depletion leads to dysfunction of motor and cognition via regulating glia-dependent neuronal migration during brain development.

DCX GLI2

3.38e-051619230250269
Pubmed

Cortical Neural Stem Cell Lineage Progression Is Regulated by Extrinsic Signaling Molecule Sonic Hedgehog.

DCX GLI2

4.81e-051919232234482
Pubmed

Sonic hedgehog regulates growth and morphogenesis of the tooth.

GLI2 WNT10B

5.90e-052119211044393
Pubmed

Nde1 is required for heterochromatin compaction and stability in neocortical neurons.

DCX UBA1

5.90e-052119235601919
Pubmed

E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification.

UBA1 UBA7

7.10e-052319219250909
Pubmed

Primary cilia regulate hippocampal neurogenesis by mediating sonic hedgehog signaling.

DCX GLI2

7.10e-052319218728187
Pubmed

Dual E1 activation systems for ubiquitin differentially regulate E2 enzyme charging.

UBA1 UBA7

8.42e-052519217597759
Pubmed

Basal Suppression of the Sonic Hedgehog Pathway by the G-Protein-Coupled Receptor Gpr161 Restricts Medulloblastoma Pathogenesis.

DCX GLI2

9.84e-052719229386106
Pubmed

A p53-dependent translational program directs tissue-selective phenotypes in a model of ribosomopathies.

GLI2 ULK1

9.84e-052719234242585
Pubmed

Expression of early developmental markers predicts the efficiency of embryonic stem cell differentiation into midbrain dopaminergic neurons.

DCX GLI2

1.30e-043119222889265
Pubmed

Polycomb-Mediated Repression and Sonic Hedgehog Signaling Interact to Regulate Merkel Cell Specification during Skin Development.

GLI2 WNT10B

1.48e-043319227414999
Pubmed

Derepression of sonic hedgehog signaling upon Gpr161 deletion unravels forebrain and ventricular abnormalities.

DCX GLI2

1.48e-043319230914320
Pubmed

Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry.

SCAF8 TOP2A

1.57e-043419211101529
Pubmed

Laminin-511 is an epithelial message promoting dermal papilla development and function during early hair morphogenesis.

GLI2 WNT10B

1.66e-043519218676816
Pubmed

Abnormal hair development and apparent follicular transformation to mammary gland in the absence of hedgehog signaling.

GLI2 WNT10B

2.18e-044019217199044
Pubmed

The ATG5 interactome links clathrin-mediated vesicular trafficking with the autophagosome assembly machinery.

LUC7L TOP2A ULK1

2.56e-0423019335449600
Pubmed

CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.

LUC7L LUC7L2 TOP2A BRD1

2.85e-0460519428977666
Pubmed

FOXA1 Directs H3K4 Monomethylation at Enhancers via Recruitment of the Methyltransferase MLL3.

LUC7L LUC7L2 TOP2A

3.19e-0424819327926873
Pubmed

Complementary proteomics strategies capture an ataxin-1 interactome in Neuro-2a cells.

LUC7L LUC7L2 TOP2A UBA1

4.08e-0466519430457570
Pubmed

Identification of differential protein interactors of lamin A and progerin.

LUC7L TOP2A

4.13e-045519221327095
Pubmed

The REST remodeling complex protects genomic integrity during embryonic neurogenesis.

DCX GLI2

4.43e-045719226745185
Pubmed

The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3.

LUC7L LUC7L2

4.43e-045719221555454
Pubmed

The Chromatin Remodeling Complex Chd4/NuRD Controls Striated Muscle Identity and Metabolic Homeostasis.

ULK1 MIPEP

5.08e-046119227166947
InteractionMKRN2 interactions

LUC7L2 GLI2 TOP2A UBA1 WNT10B

2.31e-05385195int:MKRN2
InteractionTUBGCP6 interactions

UBA1 TUBGCP2 BRD1

2.72e-0563193int:TUBGCP6
CytobandEnsembl 112 genes in cytogenetic band chrXp11

MAGED4 UBA1

1.05e-02377192chrXp11
GeneFamilyUbiquitin like modifier activating enzymes

UBA1 UBA7

1.81e-0510122100
Drug4-ketocyclophosphamide

DCX UBA7

9.88e-066192CID000033676
Drugamicetin

DCX UBA7

1.65e-0423192CID000028675
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A

SCAF8 LUC7L2 BRD1

3.76e-041721933428_DN
Drugtrichostatin A, Streptomyces sp.; Down 200; 1uM; PC3; HT_HG-U133A

SCAF8 LUC7L2 BRD1

3.88e-041741937105_DN
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HT_HG-U133A

SCAF8 LUC7L2 BRD1

3.88e-041741933993_DN
DrugSAHA; Down 200; 10uM; MCF7; HT_HG-U133A_EA

SCAF8 LUC7L2 BRD1

3.95e-041751931058_DN
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HT_HG-U133A

SCAF8 LUC7L2 BRD1

3.95e-041751937387_DN
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HT_HG-U133A

SCAF8 LUC7L2 BRD1

3.95e-041751936316_DN
Drugtrichostatin A, Streptomyces sp.; Down 200; 1uM; PC3; HT_HG-U133A

SCAF8 LUC7L2 BRD1

4.02e-041761936546_DN
DrugTrichostatin A, Streptomyces sp.; Down 200; 0.1uM; PC3; HT_HG-U133A

SCAF8 LUC7L2 BRD1

4.02e-041761931212_DN
Drugtrichostatin A, Streptomyces sp.; Down 200; 1uM; MCF7; HT_HG-U133A

SCAF8 LUC7L2 BRD1

4.02e-041761937499_DN
Drugtrichostatin A ; Down 200; 1uM; MCF7; HT_HG-U133A_EA

SCAF8 LUC7L2 BRD1

4.08e-04177193873_DN
Drugtrichostatin A, Streptomyces sp.; Down 200; 1uM; PC3; HT_HG-U133A

SCAF8 LUC7L2 BRD1

4.08e-041771937047_DN
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HT_HG-U133A

SCAF8 LUC7L2 BRD1

4.08e-041771936340_DN
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A

SCAF8 LUC7L2 BRD1

4.15e-041781931471_DN
Drugtrichostatin A, Streptomyces sp.; Down 200; 1uM; PC3; HT_HG-U133A

SCAF8 LUC7L2 BRD1

4.29e-041801935981_DN
DrugTrichostatin A, Streptomyces sp.; Down 200; 1uM; MCF7; HT_HG-U133A

SCAF8 LUC7L2 BRD1

4.36e-041811936951_DN
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A

SCAF8 LUC7L2 BRD1

4.36e-041811937005_DN
DrugSAHA; Down 200; 10uM; MCF7; HT_HG-U133A

SCAF8 LUC7L2 BRD1

4.57e-041841936939_DN
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; HL60; HG-U133A

LUC7L2 TUBGCP2 BRD1

5.18e-041921931971_DN
DrugFluvastatin sodium salt [93957-55-2]; Up 200; 9.2uM; PC3; HT_HG-U133A

DCX GLI2 BRD1

5.42e-041951936691_UP
DrugEnilconazole [35554-44-0]; Up 200; 13.4uM; PC3; HT_HG-U133A

DCX UBA7 WNT10B

5.42e-041951935113_UP
DrugCefepime hydrochloride [123171-59-5]; Down 200; 7.4uM; MCF7; HT_HG-U133A

TUBGCP2 MIPEP BRD1

5.58e-041971936237_DN
DrugThioridazine hydrochloride [130-61-0]; Down 200; 9.8uM; HL60; HG-U133A

WNT10B TUBGCP2 MIPEP

5.58e-041971931986_DN
Drugglyoxal

DCX UBA7

7.58e-0449192CID000007860
Drugn-heptyl-beta-D-thioglucoside

COG2 BRD1

8.86e-0453192CID000561567
DiseaseAdenoid Cystic Carcinoma

TOP2A BRD1

1.87e-03100192C0010606
Diseasebilirubin measurement

PYROXD1 GLI2 MIPEP

2.71e-03442193EFO_0004570
DiseaseSquamous cell carcinoma

UBA1 UBA7

2.86e-03124192C0007137
Diseaseblood urea nitrogen measurement

SCAF8 MIPEP KLB

2.88e-03452193EFO_0004741
DiseaseAdenocarcinoma of lung (disorder)

TOP2A ULK1

7.67e-03206192C0152013

Protein segments in the cluster

PeptideGeneStartEntry
FEFLMDRFEKESHCE

BRD1

186

O95696
FDQDKSSMRLDEHDF

CPNE2

96

Q96FN4
AHFLEAVDDAFKTMD

MAGED4

606

Q96JG8
FFELDAMDHLESFIA

LUC7L

81

Q9NQ29
DHFDSDDMKLSEIDF

KIAA2026

891

Q5HYC2
KFDDESAEEIRDHFM

ODR4

361

Q5SWX8
DFDAIMDDGDHSSLF

GLI2

1511

P10070
DFFVHFMDLAEEELR

TUBGCP2

526

Q9BSJ2
MELDFGHFDERDKTS

DCX

1

O43602
SEAEKHEMRGTADFF

KLB

356

Q86Z14
EFMKEDFDVDHFVSD

COG2

21

Q14746
KKLMDRFDFGEDSEH

SCAF8

261

Q9UPN6
KEQDFFFELDAMDHL

LUC7L2

76

Q9Y383
FMFDFEISGIHLDKE

MIPEP

186

Q99797
LMFEKDDDSNFHVDF

UBA7

806

P41226
GDSIDMDFSFELFAH

PYROXD1

396

Q8WU10
KDDDSNFHMDFIVAA

UBA1

851

P22314
SKGESDDFHMDFDSA

TOP2A

1491

P11388
HDMDFGEKFSRDFLD

WNT10B

201

O00744
RMDFDEFFHHPFLDA

ULK1

266

O75385