Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	translation regulator activity, nucleic acid binding	GTPBP2 DHFR2 EIF4G1 CTIF GTPBP1	1.83e-05	112	58	5	GO:0090079
GeneOntologyMolecularFunction	alpha-aminoacyl-tRNA binding	GTPBP2 GTPBP1	2.48e-05	3	58	2	GO:1904678
GeneOntologyMolecularFunction	minor groove of adenine-thymine-rich DNA binding	HMGA2 MAPT	4.48e-04	11	58	2	GO:0003680
GeneOntologyCellularComponent	nuclear speck	FAM193B SFPQ BAZ2A MAPT CD2BP2 VIRMA GATAD2B	1.83e-04	431	58	7	GO:0016607
HumanPheno	Odontoma	APC FGF3	1.62e-05	2	21	2	HP:0011068
MousePheno	abnormal social/conspecific interaction behavior	IRS4 HMGA2 MAPT EIF4G1 APC SYN1 GATAD2B SYNGAP1	3.64e-05	421	43	8	MP:0002557
Domain	HMGI/Y_DNA-bd_CS	HMGA2 PRB3 BAZ2A PRB4 PRB2	3.54e-08	31	57	5	IPR000637
Domain	Transl_elong_EFTu/EF1A_C	GTPBP2 GTPBP1	2.53e-04	8	57	2	IPR004160
Domain	GTP_EFTU_D3	GTPBP2 GTPBP1	2.53e-04	8	57	2	PF03143
Domain	MIF4G	EIF4G1 CTIF	4.05e-04	10	57	2	SM00543
Domain	Transl_elong_EF1A/Init_IF2_C	GTPBP2 GTPBP1	4.05e-04	10	57	2	IPR009001
Domain	MIF4G	EIF4G1 CTIF	4.05e-04	10	57	2	PF02854
Domain	MIF4G-like_typ-3	EIF4G1 CTIF	4.05e-04	10	57	2	IPR003890
Domain	MIF4-like	EIF4G1 CTIF	9.37e-04	15	57	2	IPR016021
Domain	-	EIF4G1 CTIF	9.37e-04	15	57	2	1.25.40.180
Domain	AT_hook	HMGA2 BAZ2A	1.07e-03	16	57	2	PF02178
Domain	EFTu-like_2	GTPBP2 GTPBP1	1.36e-03	18	57	2	IPR004161
Domain	GTP_EFTU_D2	GTPBP2 GTPBP1	1.36e-03	18	57	2	PF03144
Domain	G_TR_2	GTPBP2 GTPBP1	1.36e-03	18	57	2	PS51722
Domain	TF_GTP-bd_dom	GTPBP2 GTPBP1	1.51e-03	19	57	2	IPR000795
Domain	Transl_B-barrel	GTPBP2 GTPBP1	3.06e-03	27	57	2	IPR009000
Domain	AT_hook	HMGA2 BAZ2A	3.06e-03	27	57	2	SM00384
Domain	AT_hook_DNA-bd_motif	HMGA2 BAZ2A	3.06e-03	27	57	2	IPR017956
Pubmed	The involvement of proline-rich protein Mus musculus predicted gene 4736 in ocular surface functions.	PRB3 PRB4 PRB2	1.76e-08	4	58	3	27588265
Pubmed	Length polymorphisms in human proline-rich protein genes generated by intragenic unequal crossing over.	PRB3 PRB4 PRB2	1.76e-08	4	58	3	2851479
Pubmed	The intriguing heterogeneity of human salivary proline-rich proteins: Short title: Salivary proline-rich protein species.	PRB3 PRB4 PRB2	4.39e-08	5	58	3	26375204
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	CCDC88C IQSEC3 SFPQ EIF4G1 AAK1 APC SYN1 ARHGAP39 VIRMA GATAD2B PCNT SYNGAP1	5.24e-08	963	58	12	28671696
Pubmed	Differential RNA splicing and post-translational cleavages in the human salivary proline-rich protein gene system.	PRB3 PRB4 PRB2	8.77e-08	6	58	3	2993301
Pubmed	Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.	IQSEC3 MAPT AAK1 APC SYN1 ARHGAP39 GTPBP1 SYNGAP1	1.12e-07	347	58	8	17114649
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	CCDC88C IRS4 EDC3 MAPT STARD9 EIF4G1 AAK1 APC VIRMA MEX3B	1.46e-06	861	58	10	36931259
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	CCDC88C FAM193B KRBA1 CD2BP2 CTIF ARHGAP39 MEX3B GATAD2B	1.59e-06	493	58	8	15368895
Pubmed	Functions of unconventional mammalian translational GTPases GTPBP1 and GTPBP2.	GTPBP2 GTPBP1	2.73e-06	2	58	2	30108131
Pubmed	PRB1, PRB2, and PRB4 coded polymorphisms among human salivary concanavalin-A binding, II-1, and Po proline-rich proteins.	PRB4 PRB2	2.73e-06	2	58	2	8554050
Pubmed	KIAA1429 protects hepatocellular carcinoma cells from ferroptotic cell death with a m6 A-dependent posttranscriptional modification of SLC7A11.	SLC7A11 VIRMA	2.73e-06	2	58	2	37830241
Pubmed	Identification of Lys-Pro-Gln as a novel cleavage site specificity of saliva-associated proteases.	PRB3 PRB4	2.73e-06	2	58	2	18463091
Pubmed	PSF suppresses tau exon 10 inclusion by interacting with a stem-loop structure downstream of exon 10.	SFPQ MAPT	2.73e-06	2	58	2	21881826
Pubmed	Cloning, expression analysis, and chromosomal mapping of GTPBP2, a novel member of the G protein family.	GTPBP2 GTPBP1	2.73e-06	2	58	2	11054535
Pubmed	Bi-allelic genetic variants in the translational GTPases GTPBP1 and GTPBP2 cause a distinct identical neurodevelopmental syndrome.	GTPBP2 GTPBP1	2.73e-06	2	58	2	38118446
Pubmed	Synapsin-1 and tau reciprocal O-GlcNAcylation and phosphorylation sites in mouse brain synaptosomes.	MAPT SYN1	2.73e-06	2	58	2	23807304
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	EDC3 MAPT ACOT9 CD2BP2 DHFR2 EIF4G1 AAK1 APC GTPBP1	2.99e-06	724	58	9	36232890
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	IQSEC3 SFPQ FBXL16 MAPT EIF4G1 AAK1 APC SYN1 ARHGAP39 GTPBP1 VIRMA SYNGAP1	3.46e-06	1431	58	12	37142655
Pubmed	NANOS2 promotes male germ cell development independent of meiosis suppression.	PRB3 PRB4 PRB2	3.53e-06	18	58	3	24183939
Pubmed	HIF-2α activation potentiates oxidative cell death in colorectal cancers by increasing cellular iron.	APC SLC7A11	8.19e-06	3	58	2	33914705
Pubmed	Molecular genetics of human salivary proteins and their polymorphisms.	PRB3 PRB4	8.19e-06	3	58	2	3055850
Pubmed	The structure and evolution of the human salivary proline-rich protein gene family.	PRB4 PRB2	8.19e-06	3	58	2	8422499
Pubmed	GTPBP1 resolves paused ribosomes to maintain neuronal homeostasis.	GTPBP2 GTPBP1	8.19e-06	3	58	2	33186095
Pubmed	Circular RNA circ_KIAA1429 accelerates hepatocellular carcinoma progression via the miR-133a-3p/high mobility group AT-hook 2 (HMGA2) axis in an m6A-dependent manner.	HMGA2 VIRMA	8.19e-06	3	58	2	37368192
Pubmed	Mouse and human GTPBP2, newly identified members of the GP-1 family of GTPase.	GTPBP2 GTPBP1	8.19e-06	3	58	2	10833435
Pubmed	cDNA clones for mouse parotid proline-rich proteins. mRNA regulation by isoprenaline and the nucleotide sequence of proline-rich protein cDNA MP5.	PRB3 PRB4	1.64e-05	4	58	2	1339347
Pubmed	Finding new posttranslational modifications in salivary proline-rich proteins.	PRB3 PRB4	1.64e-05	4	58	2	20879038
Pubmed	A new MIF4G domain-containing protein, CTIF, directs nuclear cap-binding protein CBP80/20-dependent translation.	EIF4G1 CTIF	1.64e-05	4	58	2	19648179
Pubmed	Common variants at 12q15 and 12q24 are associated with infant head circumference.	HMGA2 MAPT	1.64e-05	4	58	2	22504419
Pubmed	Subtractive hybridization reveals the expression of immunoglobulin-like transcript 7, Eph-B1, granzyme B, and 3 novel transcripts in human plasmacytoid dendritic cells.	LRRC25 LILRA4	1.64e-05	4	58	2	12384430
Pubmed	Basic proline-rich proteins from human parotid saliva: relationships of the covalent structures of ten proteins from a single individual.	PRB4 PRB2	1.64e-05	4	58	2	1849422
Pubmed	Fibril treatment changes protein interactions of tau and α-synuclein in human neurons.	SFPQ EDC3 MAPT CD2BP2 AAK1 SYN1 GTPBP1	1.89e-05	498	58	7	36634849
Pubmed	The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1.	SFPQ IRS4 EDC3 VIRMA CLASRP	1.99e-05	197	58	5	20811636
Pubmed	RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease.	SFPQ MAPT WDR33 ACOT9 CD2BP2 EIF4G1 GTPBP1 CLASRP	2.33e-05	713	58	8	29802200
Pubmed	CDK8 and CDK19 act redundantly to control the CFTR pathway in the intestinal epithelium.	CDK19 APC	2.72e-05	5	58	2	36545778
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	BAZ2A MAPT EIF4G1 AAK1 ARHGAP39 VIRMA GATAD2B CLASRP	4.17e-05	774	58	8	15302935
Pubmed	LRRK2 kinase inhibition prevents pathological microglial phagocytosis in response to HIV-1 Tat protein.	MAPT SYN1	5.71e-05	7	58	2	23190742
Pubmed	The distribution and characterization of endogenous protein arginine N-methyltransferase 8 in mouse CNS.	MAPT APC	5.71e-05	7	58	2	19576965
Pubmed	Phosphoproteomic analysis of the developing mouse brain.	ENAM MAPT SYN1 ARHGAP39 GATAD2B	5.74e-05	246	58	5	15345747
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	IQSEC3 BAZ2A STARD9 CDK19 VIRMA PCNT	5.99e-05	407	58	6	12693553
Pubmed	The cytoskeleton-associated protein SCHIP1 is involved in axon guidance, and is required for piriform cortex and anterior commissure development.	SCHIP1 NRP2	7.60e-05	8	58	2	25953347
Pubmed	Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling.	APC PCNT	7.60e-05	8	58	2	29170395
Pubmed	The LIM-only protein DRAL/FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is recruited to adhesion complexes.	ITGA7 REV1	7.60e-05	8	58	2	10906324
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	CCDC88C EDC3 ACOT9 AAK1 APC CTIF GTPBP1 PCNT	8.21e-05	853	58	8	28718761
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	CCDC88C IRS4 LNX2 EDC3 FBXL16 APC	9.91e-05	446	58	6	24255178
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	IQSEC3 SFPQ MAPT ACOT9 AAK1 APC ARHGAP39 GATAD2B SYNGAP1	1.06e-04	1139	58	9	36417873
Pubmed	Recognition sequences for the GYF domain reveal a possible spliceosomal function of CD2BP2.	SFPQ CD2BP2	1.22e-04	10	58	2	15105431
Pubmed	RC3H1 post-transcriptionally regulates A20 mRNA and modulates the activity of the IKK/NF-κB pathway.	SFPQ IRS4 CD2BP2 EIF4G1	1.37e-04	156	58	4	26170170
Pubmed	Transcriptional heterogeneity of ventricular zone cells in the ganglionic eminences of the mouse forebrain.	HMGA2 MAPT NRP2	1.41e-04	60	58	3	35175194
Pubmed	Folate Metabolism Regulates Oligodendrocyte Survival and Differentiation by Modulating AMPKα Activity.	DHFR2 APC	1.49e-04	11	58	2	28496133
Pubmed	The adenomatous polyposis coli protein is an essential regulator of radial glial polarity and construction of the cerebral cortex.	APC PCNT	1.49e-04	11	58	2	19146812
Pubmed	Apaf1-deficient cortical neurons exhibit defects in axonal outgrowth.	MAPT PCNT	1.78e-04	12	58	2	25975226
Pubmed	A branching model of lineage differentiation underpinning the neurogenic potential of enteric glia.	HMGA2 FRAT1	1.78e-04	12	58	2	37737269
Pubmed	High-throughput sequence identification of gene coding variants within alcohol-related QTLs.	ADRA2B MAPT NRP2	1.79e-04	65	58	3	11471062
Pubmed	Essential role of Rac1 and Rac3 GTPases in neuronal development.	MAPT SYN1	2.46e-04	14	58	2	19126596
Pubmed	Amyloid Precursor Protein (APP) May Act as a Substrate and a Recognition Unit for CRL4CRBN and Stub1 E3 Ligases Facilitating Ubiquitination of Proteins Involved in Presynaptic Functions and Neurodegeneration.	FBXL16 MAPT SYN1	3.18e-04	79	58	3	27325702
Pubmed	Cyclin F-Mediated Degradation of SLBP Limits H2A.X Accumulation and Apoptosis upon Genotoxic Stress in G2.	EIF4G1 CTIF	3.23e-04	16	58	2	27773672
Pubmed	N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.	CD2BP2 EIF4G1 AAK1 APC PCNT	3.38e-04	360	58	5	33111431
Pubmed	Phosphoproteomic analysis of synaptosomes from human cerebral cortex.	MAPT SYN1	3.66e-04	17	58	2	15822905
Pubmed	Transcription factor Foxp3 and its protein partners form a complex regulatory network.	WDR33 CD2BP2 EIF4G1 AAK1 VIRMA	3.83e-04	370	58	5	22922362
Pubmed	Daple coordinates organ-wide and cell-intrinsic polarity to pattern inner-ear hair bundles.	CCDC88C PCNT	4.11e-04	18	58	2	29229865
Pubmed	IgSF21 promotes differentiation of inhibitory synapses via binding to neurexin2α.	SYN1 SYNGAP1	4.11e-04	18	58	2	28864826
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	SFPQ HMGA2 WDR33 CD2BP2 EIF4G1 APC ARHGAP39 SYNGAP1	4.13e-04	1082	58	8	38697112
Pubmed	The Tumor Suppressor CIC Directly Regulates MAPK Pathway Genes via Histone Deacetylation.	CCDC88C SFPQ IRS4 BAZ2A GTPBP1 GATAD2B	4.18e-04	583	58	6	29844126
Pubmed	Identification of a USP9X Substrate NFX1-123 by SILAC-Based Quantitative Proteomics.	CCDC88C CD2BP2 EIF4G1 GTPBP1 GATAD2B	4.53e-04	384	58	5	31059266
Pubmed	Synapsin and synaptic vesicle protein expression during embryonic and post-natal lens fiber cell differentiation.	MAPT SYN1	4.59e-04	19	58	2	15529118
Pubmed	Differential regulation of microtubule severing by APC underlies distinct patterns of projection neuron and interneuron migration.	MAPT APC	5.09e-04	20	58	2	25535916
Pubmed	Dlx transcription factors promote migration through repression of axon and dendrite growth.	MAPT NRP2	5.62e-04	21	58	2	17582329
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	SPAG1 SFPQ IRS4 HMGA2 WDR33 STARD9 DZIP1L EIF4G1 PCNT	6.02e-04	1442	58	9	35575683
Pubmed	EMX2-GPR156-Gαi reverses hair cell orientation in mechanosensory epithelia.	CCDC88C PCNT	6.18e-04	22	58	2	34001891
Pubmed	Identification of Human Neuronal Protein Complexes Reveals Biochemical Activities and Convergent Mechanisms of Action in Autism Spectrum Disorders.	EIF4G1 GATAD2B PCNT	6.53e-04	101	58	3	26949739
Pubmed	Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	IQSEC3 CDK19 AAK1	7.11e-04	104	58	3	10470851
Pubmed	Neurofibromatosis-1 regulates neuronal and glial cell differentiation from neuroglial progenitors in vivo by both cAMP- and Ras-dependent mechanisms.	APC SYN1	7.37e-04	24	58	2	18371380
Pubmed	Gene network analysis in a pediatric cohort identifies novel lung function genes.	WDR33 CTIF	7.37e-04	24	58	2	24023788
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	SFPQ IRS4 BAZ2A EIF4G1 VIRMA PCNT	7.57e-04	653	58	6	22586326
Pubmed	Rheb1 is required for mTORC1 and myelination in postnatal brain development.	MAPT APC	8.00e-04	25	58	2	21238928
Pubmed	Adenomatous polyposis coli is required for early events in the normal growth and differentiation of the developing cerebral cortex.	APC PCNT	8.00e-04	25	58	2	19149881
Pubmed	SALM4 suppresses excitatory synapse development by cis-inhibiting trans-synaptic SALM3-LAR adhesion.	SYN1 SYNGAP1	8.00e-04	25	58	2	27480238
Pubmed	Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome.	IQSEC3 SYN1 ARHGAP39 SYNGAP1	8.28e-04	251	58	4	27507650
Pubmed	Targeted and Interactome Proteomics Revealed the Role of PHD2 in Regulating BRD4 Proline Hydroxylation.	SFPQ IRS4 CD2BP2 EIF4G1 GATAD2B	8.45e-04	441	58	5	31239290
Pubmed	Identification of proximal SUMO-dependent interactors using SUMO-ID.	SFPQ EDC3 EIF4G1 AAK1 GATAD2B	8.71e-04	444	58	5	34795231
Pubmed	USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities.	SCHIP1 FRAT1 MAPT SYN1 HPSE2 SLC7A11	8.91e-04	674	58	6	37196079
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	FAM193B SFPQ IRS4 EDC3 BAZ2A AAK1 PCNT	9.00e-04	934	58	7	33916271
Pubmed	Identification of FUBP1 as a Long Tail Cancer Driver and Widespread Regulator of Tumor Suppressor and Oncogene Alternative Splicing.	SFPQ EIF4G1 VIRMA	9.28e-04	114	58	3	31553912
Pubmed	Laser capture microdissection and cDNA array analysis for identification of mouse KIAA/FLJ genes differentially expressed in the embryonic dorsal spinal cord.	BAZ2A ARHGAP39	9.34e-04	27	58	2	19026994
Pubmed	HENA, heterogeneous network-based data set for Alzheimer's disease.	SFPQ APC GATAD2B	1.08e-03	120	58	3	31413325
Pubmed	High-sensitivity profiling of SARS-CoV-2 noncoding region-host protein interactome reveals the potential regulatory role of negative-sense viral RNA.	SFPQ WDR33 EIF4G1 GTPBP1 GATAD2B	1.11e-03	469	58	5	37314180
Pubmed	mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis.	SFPQ IRS4 EIF4G1 GTPBP1	1.14e-03	274	58	4	34244482
Pubmed	Expression of early developmental markers predicts the efficiency of embryonic stem cell differentiation into midbrain dopaminergic neurons.	MAPT SYN1	1.23e-03	31	58	2	22889265
Pubmed	Physiological and pathophysiological characteristics of ataxin-3 isoforms.	SFPQ IRS4 ACOT9 EIF4G1	1.26e-03	281	58	4	30455355
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	IQSEC3 AAK1 ARHGAP39 SYNGAP1	1.26e-03	281	58	4	28706196
Pubmed	Poly(ADP-ribosyl)ation of BRD7 by PARP1 confers resistance to DNA-damaging chemotherapeutic agents.	IRS4 ACOT9 EIF4G1 GTPBP1 PCNT	1.30e-03	486	58	5	30940648
Pubmed	Differential gene expression profiling of the molar tooth germ in peroxisome proliferator-activated receptor-alpha (PPAR-alpha) knockout mouse and in wild-type mouse: molar tooth phenotype of PPAR-alpha knockout mouse.	ENAM HMGA2	1.31e-03	32	58	2	19320717
Pubmed	A network of heterochronic genes including Imp1 regulates temporal changes in stem cell properties.	HMGA2 APC	1.31e-03	32	58	2	24192035
Pubmed	Single-cell transcriptomic analysis reveals diversity within mammalian spinal motor neurons.	MAPT NRP2	1.31e-03	32	58	2	36596814
Pubmed	Identification of 14-3-3epsilon substrates from embryonic murine brain.	SFPQ EDC3 SYN1	1.42e-03	132	58	3	16944949
Pubmed	Postmitotic Hoxa5 Expression Specifies Pontine Neuron Positional Identity and Input Connectivity of Cortical Afferent Subsets.	MAPT NRP2	1.48e-03	34	58	2	32553152
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	EDC3 EIF4G1 AAK1 APC GATAD2B	1.51e-03	503	58	5	16964243
Pubmed	New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.	ENAM CCDC88C SFPQ IRS4 STARD9	1.65e-03	513	58	5	25798074
Pubmed	An interactome perturbation framework prioritizes damaging missense mutations for developmental disorders.	LNX2 EDC3 SMUG1 DZIP1L CLASRP	1.66e-03	514	58	5	29892012
Interaction	YWHAZ interactions	CCDC88C SFPQ ADRA2B IRS4 LNX2 EDC3 MAPT STARD9 AAK1 APC SYN1 VIRMA MEX3B PCNT SYNGAP1	2.59e-06	1319	57	15	int:YWHAZ
Interaction	TSPAN11 interactions	ITGA7 VIRMA NRP2	6.01e-06	13	57	3	int:TSPAN11
Interaction	YWHAG interactions	CCDC88C IRS4 LNX2 SHROOM1 EDC3 MAPT STARD9 DZIP1L EIF4G1 AAK1 APC VIRMA MEX3B SYNGAP1	7.06e-06	1248	57	14	int:YWHAG
Interaction	PPP1R2B interactions	MAPT AAK1 VIRMA	7.64e-06	14	57	3	int:PPP1R2B
Interaction	YWHAH interactions	CCDC88C IRS4 SHROOM1 EDC3 MAPT STARD9 EIF4G1 AAK1 APC VIRMA MEX3B PCNT SYNGAP1	9.39e-06	1102	57	13	int:YWHAH
Interaction	TNIK interactions	IQSEC3 MAPT APC ARHGAP39 GTPBP1 VIRMA GATAD2B SYNGAP1	1.12e-05	381	57	8	int:TNIK
Interaction	SFN interactions	CCDC88C SFPQ IRS4 LNX2 EDC3 MAPT EIF4G1 AAK1 APC VIRMA	2.14e-05	692	57	10	int:SFN
Interaction	AAK1 interactions	MAPT ACOT9 AAK1 VIRMA SYNGAP1	2.34e-05	121	57	5	int:AAK1
Interaction	SYNGAP1 interactions	LNX2 MAPT AAK1 SYN1 ARHGAP39 PCNT SYNGAP1	2.45e-05	307	57	7	int:SYNGAP1
Interaction	NYAP2 interactions	ACOT9 VIRMA SYNGAP1	3.65e-05	23	57	3	int:NYAP2
Interaction	KATNA1 interactions	CCDC88C MAPT EIF4G1 ARHGAP39	4.09e-05	68	57	4	int:KATNA1
Interaction	GSK3A interactions	FAM193B KRBA1 EDC3 FRAT1 MAPT WDR33 APC DDI1	4.57e-05	464	57	8	int:GSK3A
Interaction	DMXL2 interactions	LRRC25 VIRMA PCNT SYNGAP1	5.13e-05	72	57	4	int:DMXL2
Interaction	AP2B1 interactions	MAPT AAK1 APC CTIF VIRMA MEX3B PCNT	8.39e-05	373	57	7	int:AP2B1
Interaction	YWHAB interactions	CCDC88C IRS4 SHROOM1 EDC3 MAPT STARD9 EIF4G1 AAK1 APC VIRMA MEX3B	1.09e-04	1014	57	11	int:YWHAB
Interaction	FMR1 interactions	SFPQ MAPT EIF4G1 APC VIRMA MEX3B PCNT SYNGAP1	1.25e-04	536	57	8	int:FMR1
Interaction	SPTBN2 interactions	MAPT APC VIRMA PCNT SYNGAP1	1.25e-04	172	57	5	int:SPTBN2
Interaction	WDR7 interactions	SFPQ MAPT VIRMA SYNGAP1	1.39e-04	93	57	4	int:WDR7
Interaction	AKNA interactions	CD2BP2 VIRMA	1.64e-04	7	57	2	int:AKNA
Interaction	SMG1 interactions	SMUG1 CTIF VIRMA MEX3B	1.64e-04	97	57	4	int:SMG1
Interaction	DCP2 interactions	GTPBP2 EDC3 LRRC25 MAPT	1.64e-04	97	57	4	int:DCP2
Interaction	AGO1 interactions	MAPT EIF4G1 CTIF VIRMA MEX3B	1.67e-04	183	57	5	int:AGO1
Interaction	PARD3 interactions	CCDC88C IRS4 APC ARHGAP39 VIRMA MEX3B	1.91e-04	298	57	6	int:PARD3
Interaction	AP2M1 interactions	SFPQ MAPT CD2BP2 AAK1 APC CTIF MEX3B	2.02e-04	430	57	7	int:AP2M1
Cytoband	12p13.2	PRB3 PRB4 PRB2	2.61e-05	45	58	3	12p13.2
Cytoband	Ensembl 112 genes in cytogenetic band chr12p13	IQSEC3 PRB3 PRB4 PRB2	1.05e-03	353	58	4	chr12p13
GeneFamily	Proline rich proteins	PRB3 PRB4 PRB2	1.00e-07	6	32	3	972
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	SFPQ MAPT CD2BP2 APC	2.81e-04	181	32	4	694
ToppCell	facs-Heart-LV-24m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IQSEC3 ADRA2B MAPT DZIP1L ITGA7	3.17e-06	174	58	5	7cd6f9103133f8d7b90f9ff4b3b0b078cf554542
ToppCell	facs-Heart-LV-24m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IQSEC3 ADRA2B MAPT DZIP1L ITGA7	3.17e-06	174	58	5	a0a059bb2a64d7011e206db2ebcdf3eb655a925a
Drug	catechin; Down 200; 11uM; MCF7; HT_HG-U133A_EA	FAM193B GTPBP2 SFPQ EDC3 CDK19 APC SLC7A11	6.99e-07	198	58	7	1101_DN
Drug	Gossypol [303-45-7]; Up 200; 7.8uM; MCF7; HT_HG-U133A	GTPBP2 WDR33 AAK1 HPSE2 SLC7A11 NRP2	6.26e-06	179	58	6	4762_UP
Drug	Nifedipine [21829-25-4]; Up 200; 11.6uM; PC3; HT_HG-U133A	CCDC88C BAZ2A APC MRNIP SLC7A11 NRP2	9.92e-06	194	58	6	7303_UP
Drug	Pantothenic acid calcium salt monohydrate [63409-48-3]; Up 200; 8uM; PC3; HT_HG-U133A	BAZ2A PRB4 AAK1 APC HPSE2 NRP2	1.11e-05	198	58	6	4189_UP
Disease	amnestic disorder (implicated_via_orthology)	IRS4 MAPT	1.26e-04	9	56	2	DOID:10914 (implicated_via_orthology)
Disease	late onset Parkinson's disease (is_implicated_in)	MAPT EIF4G1	1.92e-04	11	56	2	DOID:0060892 (is_implicated_in)
Disease	Intellectual Disability	IQSEC3 GTPBP2 ADRA2B ACOT9 APC SYNGAP1	2.00e-04	447	56	6	C3714756
Disease	information processing speed	MAPT PRB2 MEX3B	5.73e-04	85	56	3	EFO_0004363
Disease	Splenomegaly	MAPT APC	7.98e-04	22	56	2	C0038002

Protein segments in the cluster

Peptide	Gene	Start	Entry
QLKNGAAGGPRPAPT	CERS4	361	Q9HA82
AGSLGQKPQRPRRPA	C8G	16	P07360
PNKKPRLGPSGANSG	CDK19	436	Q9BWU1
RQQRPPGGNKPQQHG	CTIF	196	O43310
PRQRPKAGQTQPNPG	AAK1	366	Q2M2I8
QSPTGLGQPKRRGRP	BAZ2A	1396	Q9UIF9
LQPQPKPSSGGRRRG	GTPBP1	636	O00178
GRNRGGKANNPPYLP	GTPBP2	46	Q9BX10
LTPGRGLTQGPQNPK	ACOT9	16	Q9Y305
KGDQGPQPRGRPQCK	ADRA2B	151	P18089
QAGSPQRSPGRKPRP	ARHGAP39	341	Q9C0H5
QRDPRPAGPAQAKQG	MRNIP	251	Q6NTE8
AGPQRAATPGRKPQL	DZIP1L	701	Q8IYY4
QKDNVGPRAPGRAPN	DDI1	76	Q8WTU0
NRLGRRPQGPGPMGQ	KRBA1	836	A5PL33
DGLPQRPGRQPQAGL	LILRA4	261	P59901
AAQDGPKPGLGLQPR	LRRC25	206	Q8N386
VRQLQSGLPRPPGKG	FGF3	191	P11487
PGKPQPGNTIREAGN	LNX2	421	Q8N448
PRNGPLPQEGAQKRG	CCDC88C	1636	Q9P219
RGQPDPPCGGRLNSK	NRP2	21	O60462
GGPNRLNPKNVHQRP	EDC3	321	Q96F86
AQLQGQRGPPKPGLV	GATAD2B	271	Q8WXI9
QNLRNPAKSRGGPGP	HPSE2	126	Q8WWQ2
RAGPQHKASPGRQQP	IQSEC3	261	Q9UPP2
AQGKAPRPGPRARQP	PCNT	3226	O95613
GRKGPGQPSSPQRLD	CD2BP2	186	O95400
SGPARPQSLPQGKGR	FAM193B	816	Q96PV7
QPPGSKSRPHRQGAQ	DCDC2B	226	A2VCK2
PAGLGPRRSQQGPRK	EIF4G1	696	Q04637
GKQGIPQPLSGPCRR	FRAT1	156	Q92837
GIGKNGDLPRPPLRN	DHFR2	16	Q86XF0
QGQPAAPAPQKRGRG	HMGA2	16	P52926
QGPGQKGLCSPRPNI	ITGA7	931	Q13683
GNPANLRRKPQGPNK	ENAM	396	Q9NRM1
QGPPPQGGSKSRSAR	PRB2	346	P02812
GKPEGRPPQGGNQSQ	PRB4	76	P10163
KPEGRPPQGGNQSQG	PRB4	161	P10163
AGAIPKNPRNPQGGS	IRS4	786	O14654
RNKNTALNGAVPGPP	MEX3B	141	Q6ZN04
PRNGLVKLPGQPNGL	FBXL16	16	Q8N461
KASGAPPGGQQRQGP	SYN1	576	P17600
RGPRRAIQKPQPAGG	SCHIP1	176	P0DPB3
PGTAGRGPLANQQRK	SHROOM1	206	Q2M3G4
NRLGGNRPTNNRGQP	STARD9	1161	Q9P2P6
PGRNGISPPNKLSQL	APC	2331	P25054
QPGGPAPGRNASARR	CLASRP	361	Q8N2M8
FRSPPPGMGLNQNRG	SFPQ	31	P23246
KPEGRPPQGGNQSQG	PRB3	56	Q04118
NGRLPSLGNKEPPGQ	SLC7A11	21	Q9UPY5
GGGQPPPLQRGKSQQ	SYNGAP1	1061	Q96PV0
TSPGRKQNGIPHPRG	REV1	206	Q9UBZ9
GKRPARGAPQRGQTP	SPAG1	396	Q07617
PRGAAPPGQKGQANA	MAPT	471	P10636
GLLHPSPRNPQANKG	SMUG1	236	Q53HV7
LNPGQGPGPNKGDSR	WDR33	946	Q9C0J8
RGGQSNFNRGPLPPL	VIRMA	1741	Q69YN4
NQGPKLRGPGARRPS	VWA5B1	721	Q5TIE3
RGRQGASKQQPAPPP	KCNC3	11	Q14003