Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	helicase activity	MRE11 ERCC6L DDX25 RAD54L2 XRCC6	1.21e-04	158	61	5	GO:0004386
GeneOntologyCellularComponent	cytoplasmic stress granule	TARDBP FMR1 DDX25 KPNB1	1.90e-04	96	62	4	GO:0010494
GeneOntologyCellularComponent	nuclear speck	ZC3H14 TARDBP ZNF106 CTR9 ATOH8 CARMIL1 RAD54L2	2.79e-04	431	62	7	GO:0016607
GeneOntologyCellularComponent	nuclear body	BMI1 MRE11 ZC3H14 TARDBP ZNF106 FMR1 CTR9 ATOH8 CARMIL1 RAD54L2	3.01e-04	903	62	10	GO:0016604
HumanPheno	Chronic kidney disease	GON7 ANLN B2M TTC21B STOX1 BICC1	2.46e-05	194	17	6	HP:0012622
Domain	RDM	RFPL4A RFPL4AL1	1.08e-04	5	62	2	PF11002
Domain	RDM_domain_RFPL	RFPL4A RFPL4AL1	1.08e-04	5	62	2	IPR022723
Domain	SNF2_N	ERCC6L RAD54L2	5.04e-03	32	62	2	IPR000330
Domain	SNF2_N	ERCC6L RAD54L2	5.04e-03	32	62	2	PF00176
Domain	Helicase_C	ERCC6L DDX25 RAD54L2	5.41e-03	107	62	3	PF00271
Domain	HELICc	ERCC6L DDX25 RAD54L2	5.41e-03	107	62	3	SM00490
Domain	Helicase_C	ERCC6L DDX25 RAD54L2	5.55e-03	108	62	3	IPR001650
Domain	HELICASE_CTER	ERCC6L DDX25 RAD54L2	5.70e-03	109	62	3	PS51194
Domain	HELICASE_ATP_BIND_1	ERCC6L DDX25 RAD54L2	5.70e-03	109	62	3	PS51192
Domain	DEXDc	ERCC6L DDX25 RAD54L2	5.70e-03	109	62	3	SM00487
Domain	Helicase_ATP-bd	ERCC6L DDX25 RAD54L2	5.84e-03	110	62	3	IPR014001
Domain	KH_1	FMR1 BICC1	7.06e-03	38	62	2	PF00013
Domain	-	FMR1 BICC1	7.42e-03	39	62	2	3.30.1370.10
Domain	KH	FMR1 BICC1	7.80e-03	40	62	2	SM00322
Domain	KH_dom	FMR1 BICC1	7.80e-03	40	62	2	IPR004087
Domain	KH_TYPE_1	FMR1 BICC1	8.57e-03	42	62	2	PS50084
Domain	PRY	RFPL4A RFPL4AL1	8.57e-03	42	62	2	PF13765
Domain	KH_dom_type_1	FMR1 BICC1	9.38e-03	44	62	2	IPR004088
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	MRE11 ZC3H14 TARDBP ANK2 ERCC6L LYPLA2 CARMIL1 TSNAX XRCC6 AFF4 KPNB1	7.19e-07	934	62	11	33916271
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	MAGI1 ZNF106 ERCC6L TRPM7 ANLN CARMIL1 CAMSAP3 CRYBG3 PLK4 BICC1	2.76e-06	861	62	10	36931259
Pubmed	TDP-43 Regulates Coupled Dendritic mRNA Transport-Translation Processes in Co-operation with FMRP and Staufen1.	TARDBP FMR1	3.13e-06	2	62	2	31801077
Pubmed	CGG repeats in RNA modulate expression of TDP-43 in mouse and fly models of fragile X tremor ataxia syndrome.	TARDBP FMR1	3.13e-06	2	62	2	24986919
Pubmed	Decreased expression of DNA repair proteins Ku70 and Mre11 is associated with aging and may contribute to the cellular senescence.	MRE11 XRCC6	3.13e-06	2	62	2	17202845
Pubmed	Co-regulation of mRNA translation by TDP-43 and Fragile X Syndrome protein FMRP.	TARDBP FMR1	3.13e-06	2	62	2	27518042
Pubmed	Gene mapping in a murine cell line by immunoselection with cytotoxic T lymphocytes.	ZNF106 B2M	9.37e-06	3	62	2	7514566
Pubmed	Mre11 and Ku70 interact in somatic cells, but are differentially expressed in early meiosis.	MRE11 XRCC6	9.37e-06	3	62	2	10508516
Pubmed	Human Ku70/80 protein blocks exonuclease 1-mediated DNA resection in the presence of human Mre11 or Mre11/Rad50 protein complex.	MRE11 XRCC6	1.87e-05	4	62	2	22179609
Pubmed	Neurodegeneration-associated TDP-43 interacts with fragile X mental retardation protein (FMRP)/Staufen (STAU1) and regulates SIRT1 expression in neuronal cells.	TARDBP FMR1	1.87e-05	4	62	2	22584570
Pubmed	mRNA transport, translation, and decay in adult mammalian central nervous system axons.	TARDBP FMR1	1.87e-05	4	62	2	36584679
Pubmed	RNA-binding proteins in neurological development and disease.	TARDBP FMR1	1.87e-05	4	62	2	32865115
Pubmed	Identification of an acetylation-dependant Ku70/FLIP complex that regulates FLIP expression and HDAC inhibitor-induced apoptosis.	CFLAR XRCC6	1.87e-05	4	62	2	22322857
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	MRE11 TARDBP ANLN MARK1 CTR9 ZNF652 TSNAX GFPT2 BICC1 AFF4	2.05e-05	1084	62	10	11544199
Pubmed	Ku70 acetylation and modulation of c-Myc/ATF4/CHOP signaling axis by SIRT1 inhibition lead to sensitization of HepG2 cells to TRAIL through induction of DR5 and down-regulation of c-FLIP.	CFLAR XRCC6	3.12e-05	5	62	2	23247197
Pubmed	The ret finger protein-like 4 gene, Rfpl4, encodes a putative E3 ubiquitin-protein ligase expressed in adult germ cells.	RFPL4A RFPL4AL1	3.12e-05	5	62	2	11850190
Pubmed	Responses against antigens encoded by the H-3 histocompatibility locus: antigens stimulating class I MHC- and class II MHC-restricted T cells are encoded by separate genes.	ZNF106 B2M	3.12e-05	5	62	2	2530167
Pubmed	New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.	KCNH7 MARK1 ASXL3 CAMSAP3 TTC21B XRCC6 KPNB1	3.56e-05	513	62	7	25798074
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	MAGI1 MRE11 ANK2 ERCC6L CARMIL1 CRYBG3 XRCC6 KPNB1	3.64e-05	708	62	8	39231216
Pubmed	Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification.	MRE11 ZNF106 CTR9 RAD54L2 AFF4	4.88e-05	222	62	5	37071664
Pubmed	ENU mutagenesis in mice identifies candidate genes for hypogonadism.	PLK4 BICC1	6.53e-05	7	62	2	22258617
Pubmed	MRN complex function in the repair of chromosomal Rag-mediated DNA double-strand breaks.	MRE11 XRCC6	6.53e-05	7	62	2	19221393
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	MRE11 ZNF106 ERCC6L ANLN CTR9 CARMIL1 CAMSAP3 XRCC6	6.80e-05	774	62	8	15302935
Pubmed	VE-822 upregulates the deubiquitinase OTUD1 to stabilize FHL1 to inhibit the progression of lung adenocarcinoma.	TARDBP FMR1 XRCC6 KPNB1	6.87e-05	122	62	4	36929488
Pubmed	Nuclear localization of Beclin 1 promotes radiation-induced DNA damage repair independent of autophagy.	MRE11 XRCC6	8.69e-05	8	62	2	28345663
Pubmed	The human Rap1 protein complex and modulation of telomere length.	MRE11 XRCC6	8.69e-05	8	62	2	15100233
Pubmed	RFPL4 interacts with oocyte proteins of the ubiquitin-proteasome degradation pathway.	RFPL4A RFPL4AL1	8.69e-05	8	62	2	12525704
Pubmed	PHF11 promotes DSB resection, ATR signaling, and HR.	MRE11 XRCC6	1.12e-04	9	62	2	28115467
Pubmed	Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant.	MAGI1 FMR1 MARK1 CAMSAP3 MAP3K13 STOX1	1.18e-04	430	62	6	32581705
Pubmed	mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis.	MAGI1 ZC3H14 TARDBP FMR1 KPNB1	1.31e-04	274	62	5	34244482
Pubmed	Expression screening of a yeast artificial chromosome contig refines the location of the mouse H3a minor histocompatibility antigen gene.	ZNF106 B2M	1.39e-04	10	62	2	9670959
Pubmed	Identification of proximal SUMO-dependent interactors using SUMO-ID.	ZNF280A TARDBP ZNF106 ERCC6L ANLN RAD54L2	1.41e-04	444	62	6	34795231
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	MRE11 ZC3H14 ANLN CTR9 ZNF652 TSNAX RAD54L2 XRCC6 KPNB1	1.41e-04	1103	62	9	34189442
Pubmed	Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins.	MRE11 XRCC6	1.70e-04	11	62	2	15383534
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	TARDBP ZNF106 PPP2R2D ERCC6L ANLN CARMIL1 PLK4 XRCC6 KPNB1	1.99e-04	1155	62	9	20360068
Pubmed	Elucidating novel hepatitis C virus-host interactions using combined mass spectrometry and functional genomics approaches.	TARDBP KPNB1	2.04e-04	12	62	2	24169621
Pubmed	MRI Is a DNA Damage Response Adaptor during Classical Non-homologous End Joining.	MRE11 XRCC6	2.04e-04	12	62	2	30017584
Pubmed	SENP3 regulates the global protein turnover and the Sp1 level via antagonizing SUMO2/3-targeted ubiquitination and degradation.	MRE11 ZC3H14 KPNB1	2.08e-04	64	62	3	26511642
Pubmed	Transcriptional and posttranscriptional regulation of HIV-1 gene expression.	AFF4 KPNB1	2.41e-04	13	62	2	22355797
Pubmed	Transcriptional elongation factor ENL phosphorylated by ATM recruits polycomb and switches off transcription for DSB repair.	BMI1 AFF4	2.81e-04	14	62	2	25921070
Pubmed	The deubiquitinase USP9X regulates FBW7 stability and suppresses colorectal cancer.	MRE11 FMR1 KPNB1	2.83e-04	71	62	3	29346117
Pubmed	Analysis of the Histone H3.1 Interactome: A Suitable Chaperone for the Right Event.	MRE11 STK36 CAMSAP3 XRCC6	3.19e-04	182	62	4	26527279
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	ZC3H14 TARDBP ZNF106 ANLN CTR9 XRCC6 AFF4 KPNB1	3.61e-04	989	62	8	36424410
Pubmed	Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans.	MAP3K13 PLK4	3.69e-04	16	62	2	8274451
Pubmed	Genes linked to energy metabolism and immunoregulatory mechanisms are associated with subcutaneous adipose tissue distribution in HIV-infected men.	MARK1 GFPT2	4.18e-04	17	62	2	21897333
Pubmed	Severe muscle wasting and denervation in mice lacking the RNA-binding protein ZFP106.	TARDBP ZNF106	4.18e-04	17	62	2	27418600
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	ZBTB38 ANK2 TRPM7 CTR9 GFPT2 RAD54L2 XRCC6 AFF4 KPNB1	4.34e-04	1285	62	9	35914814
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	MRE11 ZC3H14 TARDBP ERCC6L ANLN KPNB1	4.38e-04	549	62	6	38280479
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	MRE11 ZC3H14 TARDBP ZNF106 FMR1 CTR9 MXD4 XRCC6 KPNB1	4.57e-04	1294	62	9	30804502
Pubmed	Alpha thalassemia/mental retardation syndrome X-linked gene product ATRX is required for proper replication restart and cellular resistance to replication stress.	MRE11 XRCC6	5.24e-04	19	62	2	23329831
Pubmed	A major quantitative trait locus on chromosome 3 controls colitis severity in IL-10-deficient mice.	B2M MXD4	5.24e-04	19	62	2	11707574
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	MRE11 TARDBP ERCC6L ANLN XRCC6 KPNB1	5.95e-04	582	62	6	20467437
Pubmed	RAB-like 2 has an essential role in male fertility, sperm intra-flagellar transport, and tail assembly.	TARDBP TSNAX KPNB1	6.05e-04	92	62	3	23055941
Pubmed	The Polycomb Repressive Complex 1 Protein BMI1 Is Required for Constitutive Heterochromatin Formation and Silencing in Mammalian Somatic Cells.	BMI1 KPNB1	6.42e-04	21	62	2	26468281
Pubmed	Stabilization of the methyl-CpG binding protein ZBTB38 by the deubiquitinase USP9X limits the occurrence and toxicity of oxidative stress in human cells.	ZBTB38 ANLN XRCC6	6.64e-04	95	62	3	29490077
Pubmed	Phospho-tyrosine dependent protein-protein interaction network.	MRE11 STK36 ANLN CCDC33 CDCA4	8.28e-04	410	62	5	25814554
Pubmed	Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	PPP2R2D MARK1 CAMSAP3	8.40e-04	103	62	3	10819331
Pubmed	Exploring the link between MORF4L1 and risk of breast cancer.	TSNAX KPNB1	8.41e-04	24	62	2	21466675
Pubmed	An integrated workflow for charting the human interaction proteome: insights into the PP2A system.	PPP2R2D KPNB1 CDCA4	8.88e-04	105	62	3	19156129
Pubmed	Direct binding of CoREST1 to SUMO-2/3 contributes to gene-specific repression by the LSD1/CoREST1/HDAC complex.	MRE11 RAD54L2 XRCC6	9.13e-04	106	62	3	19394292
Pubmed	RBBP8/CtIP suppresses P21 expression by interacting with CtBP and BRCA1 in gastric cancer.	MRE11 XRCC6	9.14e-04	25	62	2	31636387
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	TARDBP ANK2 CTR9 CAMSAP3 ANKRD30B STOX1 RAD54L2 XRCC6 KPNB1	9.88e-04	1442	62	9	35575683
Pubmed	Elongin A regulates transcription in vivo through enhanced RNA polymerase processivity.	CTR9 AFF4	9.89e-04	26	62	2	33298525
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	FMR1 ERCC6L CTR9 CAMSAP3 CRYBG3 RAD54L2	1.05e-03	650	62	6	38777146
Pubmed	Gamma-radiation sensitivity and polymorphisms in RAD51L1 modulate glioma risk.	MRE11 XRCC6	1.07e-03	27	62	2	20610542
Pubmed	Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.	PPP2R2D ANLN MARK1 CTR9 MAP3K13 PLK4 AFF4	1.16e-03	910	62	7	36736316
Pubmed	A genetic linkage map of mouse chromosome 2 extending from thrombospondin to paired box gene 1, including the H3 minor histocompatibility complex.	ZNF106 B2M	1.23e-03	29	62	2	8617512
Pubmed	Hypertonicity-responsive ubiquitin ligase RNF183 promotes Na, K-ATPase lysosomal degradation through ubiquitination of its β1 subunit.	MRE11 ANK2 PPP2R2D LYPLA2 KPNB1	1.24e-03	449	62	5	31732153
Pubmed	C16orf72/HAPSTR1 is a molecular rheostat in an integrated network of stress response pathways.	CAMSAP3 XRCC6 KPNB1	1.28e-03	119	62	3	35776542
Pubmed	DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.	MRE11 ZNF106 ANLN RAD54L2 XRCC6	1.29e-03	453	62	5	29656893
Pubmed	The tissue-specific transcriptomic landscape of the mid-gestational mouse embryo.	LYPLA2 B2M	1.32e-03	30	62	2	24803591
Pubmed	Polycomb Group Protein CBX7 Represses Cardiomyocyte Proliferation Through Modulation of the TARDBP/RBM38 Axis.	BMI1 TARDBP	1.32e-03	30	62	2	37158107
Pubmed	A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cells.	MRE11 ANLN XRCC6	1.34e-03	121	62	3	22412018
Pubmed	DYRK1A regulates the recruitment of 53BP1 to the sites of DNA damage in part through interaction with RNF169.	TARDBP RAD54L2 KPNB1	1.37e-03	122	62	3	30773093
Pubmed	ELAVL2-directed RNA regulatory network drives the formation of quiescent primordial follicles.	RFPL4A RFPL4AL1	1.41e-03	31	62	2	31657143
Pubmed	Unbiased Identification of trans Regulators of ADAR and A-to-I RNA Editing.	MRE11 ANK2 ANLN XRCC6	1.41e-03	271	62	4	32433965
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	MRE11 ZC3H14 TARDBP ANLN XRCC6 AFF4 KPNB1	1.51e-03	954	62	7	36373674
Pubmed	A novel role for the peptidyl-prolyl cis-trans isomerase Cyclophilin A in DNA-repair following replication fork stalling via the MRE11-RAD50-NBS1 complex.	MRE11 FMR1 ANLN LYPLA2 CRYBG3	1.54e-03	472	62	5	38943005
Pubmed	EVI1 oncoprotein interacts with a large and complex network of proteins and integrates signals through protein phosphorylation.	MRE11 TSNAX XRCC6	1.57e-03	128	62	3	23858473
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	MAGI1 FMR1 ANK2 CAMSAP3 XRCC6 AFF4 KPNB1	1.60e-03	963	62	7	28671696
Pubmed	The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition.	ZC3H14 MARK1 CTR9 AFF4	1.61e-03	281	62	4	24163370
Pubmed	Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.	MRE11 TARDBP XRCC6 AFF4	1.65e-03	283	62	4	30585729
Pubmed	alphaII-Spectrin interacts with five groups of functionally important proteins in the nucleus.	MRE11 XRCC6	1.69e-03	34	62	2	16889989
Pubmed	Cdc37 interacts with the glycine-rich loop of Hsp90 client kinases.	TARDBP XRCC6	1.69e-03	34	62	2	16611982
Pubmed	An inter-species protein-protein interaction network across vast evolutionary distance.	ERCC6L TSNAX PLK4 CCDC33 CDCA4	1.71e-03	483	62	5	27107014
Pubmed	MBD5 and MBD6 stabilize the BAP1 complex and promote BAP1-dependent cancer.	ASXL3 TSNAX XRCC6 KPNB1	1.74e-03	287	62	4	36180891
Interaction	SFN interactions	MAGI1 BMI1 TARDBP ERCC6L TRPM7 ANLN MARK1 CARMIL1 CAMSAP3 CRYBG3 PLK4	5.35e-06	692	60	11	int:SFN
Cytoband	19q13.42	TMEM150B RFPL4A RFPL4AL1	6.63e-04	125	62	3	19q13.42
Cytoband	17q21.32	ZNF652 KPNB1	2.03e-03	49	62	2	17q21.32
ToppCell	PND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_G2M\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ANLN ATOH8 LRRC49 CRYBG3 CDCA4	4.42e-06	174	62	5	6c36d607c48267a75ab4da6fb2fe3f931d1b3b52
ToppCell	356C-Myeloid-Macrophage-SPP1+_Macrophage\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	MAGI1 VGLL4 GFPT2 BICC1	2.80e-05	125	62	4	43aa4b77dccf0ea2979218826af16034f2017c3a
ToppCell	TCGA-Kidney-Primary_Tumor-Renal_Cell_Carcinoma-Kidney_Clear_Cell_Renal_Carcinoma-6\|TCGA-Kidney / Sample_Type by Project: Shred V9	ERCC6L ANLN PLK4 CDCA4	6.63e-05	156	62	4	d249747c7108a0edfc72d24c09b0b0e4ed662b40
ToppCell	E16.5-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-NK-NK_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MARK1 LRRC49 B2M C2CD2L	7.32e-05	160	62	4	b2d8940ea8c068273b7da1589d3d6ae5110d8209
ToppCell	E16.5-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MARK1 LRRC49 B2M C2CD2L	7.32e-05	160	62	4	9caab1bb63c7e66c44783852ee75b16bb40fa594
ToppCell	E16.5-Immune-Immune_Lymphocytic_T/NK\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MARK1 LRRC49 B2M C2CD2L	7.32e-05	160	62	4	229841be7b984a00a301cd5d88c11226a90d8a88
ToppCell	E16.5-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-NK\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MARK1 LRRC49 B2M C2CD2L	7.32e-05	160	62	4	99c9ae2041445539fada842e1af01368669bfca0
ToppCell	356C-Myeloid-Macrophage-SPP1+_Macrophage\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	MAGI1 VGLL4 GFPT2 BICC1	8.05e-05	164	62	4	d6806deabf5f5c355934387be2baae125ac33fb8
ToppCell	Adult-Epithelial-lung_neuroendocrine_cell_(PNEC)\|Adult / Lineage, Cell type, age group and donor	KCNH7 ANK2 ASXL3 DDX25	1.03e-04	175	62	4	4db1a3c284488b3f6de7568363f176d74e2a4587
ToppCell	CV-Mild-6\|Mild / Virus stimulation, Condition and Cluster	ZNF106 HAGH STOX1 C2CD2L	1.03e-04	175	62	4	c4d530dbb37942427c9cd0a1533faeb6a3a45381
ToppCell	Adult-Epithelial-lung_neuroendocrine_cell_(PNEC)-D231\|Adult / Lineage, Cell type, age group and donor	KCNH7 ANK2 ASXL3 DDX25	1.03e-04	175	62	4	8d9f44a2633b71fb4d2b4a7d9530f954e07c4a18
ToppCell	367C-Myeloid-Dendritic-cDC_proliferating_2\|Dendritic / Donor, Lineage, Cell class and subclass (all cells)	TMEM150B ANK2 ANLN ATOH8	1.03e-04	175	62	4	bde785ff0c854646d7ab8571359e9d69a7bf013f
ToppCell	3'-Adult-Appendix-Epithelial-mature_enterocytic-Colonocyte\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ANLN MARK1 ASXL3 ANKRD30B	1.06e-04	176	62	4	23fa02d4c39e0b8faa1658116d50b6233a952ccc
ToppCell	3'-Adult-Appendix-Epithelial-mature_enterocytic\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ANLN MARK1 ASXL3 ANKRD30B	1.06e-04	176	62	4	30adf8f1638c6244586f8101c2590bb964dfae00
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Cycling_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ERCC6L ANLN PLK4 CDCA4	1.08e-04	177	62	4	73ba0f0b4b33f10e9f036d6d9befa48a1258e682
ToppCell	TCGA-Liver-Primary_Tumor-Hepatocellular_Carcinoma-Hepatocellular_Carcinoma-5\|TCGA-Liver / Sample_Type by Project: Shred V9	TARDBP ERCC6L ANLN PLK4	1.23e-04	183	62	4	f604a8b62c7088fad8365dbf8d910fc980bd3ba8
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	KCNH7 TRPM7 MARK1 STAC	1.39e-04	189	62	4	977a813e5d7a5a561c1fced2bbf21c20056b88d8
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_2_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ANK2 LRRC49 GFPT2 BICC1	1.42e-04	190	62	4	0fea33f2dc1efa23aaa2da1c318482a52a313ff1
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	KCNH7 TRPM7 MARK1 STAC	1.42e-04	190	62	4	e252e925600e6457fa6e362a55217f4cffa75cdb
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_cycling-mes_proliferating2_(11)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	ERCC6L ANLN PLK4 CDCA4	1.45e-04	191	62	4	0ba5b112a82e489f5a21966f78a403a7436ce73b
ToppCell	droplet-Lung-30m-Hematologic-myeloid-classical_monocyte_proliferating-classical_monocyte_proliferating_l12-14\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ERCC6L ANLN PLK4 CDCA4	1.48e-04	192	62	4	52d0aa51e3b6ab3608a5f40bdde9f8134b3afd94
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_cycling-mes_proliferating2_(11)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	ERCC6L ANLN PLK4 CDCA4	1.48e-04	192	62	4	27723f4e320e49d4a3daafa2d8d3946ff79fab64
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_cycling-mes_proliferating2_(11)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	ERCC6L ANLN PLK4 CDCA4	1.48e-04	192	62	4	026f3e38970bea1e6e8d76a4e2becdfb8484b2ff
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_cycling-mes_proliferating2_(11)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	ERCC6L ANLN PLK4 CDCA4	1.48e-04	192	62	4	0a54c79dcfdeb99e3b512d42b22359618cfd17e9
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_cycling-mes_proliferating3_(7)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	ERCC6L ANLN PLK4 CDCA4	1.54e-04	194	62	4	f9070035553bc68106a9e0bdf4b507715a138aba
ToppCell	(7)_Epithelial_cells-(7)_Epithelial-J_(AT1-AT2_progenitors)\|(7)_Epithelial_cells / Lung cell shreds - cell class (v4) and cell subclass (v4)	ERCC6L ANLN PLK4 CDCA4	1.54e-04	194	62	4	4d6ae2b25db11a4ae6dadee83be5c8c05b1225c3
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_2_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ANK2 CARMIL1 GFPT2 BICC1	1.57e-04	195	62	4	ff0aa455e9844a6d7ae57ff59fb6cea825cf1fc2
ToppCell	COVID-19-lung-Proliferative_fibroblast\|lung / Disease (COVID-19 only), tissue and cell type	ANLN GFPT2 PLK4 BICC1	1.60e-04	196	62	4	2ce8a787f2731faa913d20342d73041d59468f27
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_cycling-mes_proliferating3_(7)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	ERCC6L ANLN PLK4 CDCA4	1.60e-04	196	62	4	1964c5003a0cb84539850a7cfe3bbb0e23a61d2d
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_cycling\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	ERCC6L ANLN PLK4 CDCA4	1.60e-04	196	62	4	73f951f7712e0aa3323676b9a4b7944d21d347c4
ToppCell	BAL-Mild-Lymphocyte-T/NK-Other_T-T/NK_proliferative\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	ERCC6L ANLN PLK4 CDCA4	1.63e-04	197	62	4	434a5686a103bb766e0d80038413f0e12ea3981a
ToppCell	Mild_COVID-19-T/NK-proliferating_T/NK\|Mild_COVID-19 / Disease group,lineage and cell class （2021.01.30）	ERCC6L ANLN PLK4 CDCA4	1.63e-04	197	62	4	5fd52fba2cb6fa67377f873da2ff6ce9c83b0591
ToppCell	Mild-Lymphoid-T-Proliferating_T\|Mild / Condition, Lineage, Cell class and cell subclass	ERCC6L ANLN PLK4 CDCA4	1.63e-04	197	62	4	794517c70089da109f4c6489fe406c0ba6882b76
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_cycling-mes_proliferating3_(7)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	ERCC6L ANLN PLK4 CDCA4	1.63e-04	197	62	4	84ed777cdba569200a3ef1654d8a12f17fcfb7f1
ToppCell	BAL-Mild-Lymphocyte-T/NK-Other_T\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	ERCC6L ANLN PLK4 CDCA4	1.63e-04	197	62	4	6bddfa199ca812d9e518eaa02c3d4fb67e9f5b16
ToppCell	BAL-Mild-Lymphocyte-T/NK-Other_T-T/NK_proliferative-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	ERCC6L ANLN PLK4 CDCA4	1.63e-04	197	62	4	c0a71a9452febda433bc544e4ac0a79c43dcf13e
ToppCell	Healthy-T/NK_proliferative\|World / disease group, cell group and cell class	ERCC6L ANLN PLK4 CDCA4	1.63e-04	197	62	4	e90be1e7e02f736b6aab14010a912b592d6f1e80
ToppCell	BAL-Mild-Lymphocyte-T/NK-Other_T-T/NK_proliferative-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ERCC6L ANLN PLK4 CDCA4	1.63e-04	197	62	4	f34b1e34f1f0694564031077172c890b233ce8b7
ToppCell	5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_T/NK-natural_killer_cell-NK_cells-NK_cells_L.1.3.2.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ERCC6L ANLN PLK4 CDCA4	1.63e-04	197	62	4	7eb4c1cffd0366204af7e63adc8f751685601a94
ToppCell	BAL-Mild-Lymphocyte-T/NK-Other_T-T/NK_proliferative\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ERCC6L ANLN PLK4 CDCA4	1.63e-04	197	62	4	d7a9296092153cf66426911fecd810f0c1ef978e
ToppCell	BAL-Mild-Lymphocyte-T/NK-Other_T\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ERCC6L ANLN PLK4 CDCA4	1.63e-04	197	62	4	dcff23240bb7cb652d7426b29355aa74442ef6fc
ToppCell	proximal-3-Epithelial-Proliferating_Basal\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ERCC6L ANLN PLK4 CDCA4	1.69e-04	199	62	4	2263bb73d9c5693b44d91d2548305efc1b6e4079
ToppCell	proximal-Epithelial-Proliferating_Basal\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ERCC6L ANLN PLK4 CDCA4	1.69e-04	199	62	4	521ff4ae3437c8ba477a0a42b9da195af976c3ff
ToppCell	Leuk-UTI-Lymphocyte-T_NK-T_NK_proliferative\|Leuk-UTI / Disease, Lineage and Cell Type	ERCC6L ANLN PLK4 CDCA4	1.69e-04	199	62	4	87113d398585076ece86b9098781e817f8ca241b
ToppCell	COVID-19_Severe-T/NK_proliferative\|COVID-19_Severe / disease group, cell group and cell class	ERCC6L ANLN PLK4 CDCA4	1.69e-04	199	62	4	af78837f3a7641a5bd98765eef9cb4f86034048c
ToppCell	proximal-Epithelial-Proliferating_Basal-3\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ERCC6L ANLN PLK4 CDCA4	1.69e-04	199	62	4	e8549b2c4152cb23548351d9cee27c3805892cd8
ToppCell	LPS_IL1RA_TNF-Endothelial-Endothelial-FOXM1\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	PPP2R2D ERCC6L ANLN PLK4	1.73e-04	200	62	4	4cfe08878a6981bf7b3567f9e82192d8f060ddde
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW19-Stem_cells\|GW19 / Sample Type, Dataset, Time_group, and Cell type.	FMR1 ANLN STAC CDCA4	1.73e-04	200	62	4	31dd81df9aa754a1e69b905bf9b8ce73ff8175aa
ToppCell	3'-GW_trimst-2-SmallIntestine-Mesenchymal-immature_mesenchymal_cell-cycling_stromal\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ERCC6L ANLN PLK4 CDCA4	1.73e-04	200	62	4	63f9481059be608ddc9fe9c7a8f8503fce9755dd
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW19-Stem_cells-Neuroepithelial_cell\|GW19 / Sample Type, Dataset, Time_group, and Cell type.	FMR1 ANLN STAC CDCA4	1.73e-04	200	62	4	54174a485a82480726fa06efa6e050ddea77cb3c
ToppCell	Sepsis-Leuk-UTI-Lymphocyte-T/NK-T/NK_proliferative\|Leuk-UTI / Disease, condition lineage and cell class	ERCC6L ANLN PLK4 CDCA4	1.73e-04	200	62	4	093e97395be23092229521cc55aaaee8befbc149
Disease	sinoatrial node disease (implicated_via_orthology)	ANK2 TRPM7	3.80e-06	2	58	2	DOID:0050824 (implicated_via_orthology)
Disease	Ovarian Serous Adenocarcinoma	STK36 TRPM7 MARK1	1.24e-05	23	58	3	C1335177
Disease	Facies	FMR1 AFF4	1.69e-04	10	58	2	C0282631
Disease	cystic kidney disease (implicated_via_orthology)	TTC21B BICC1	1.69e-04	10	58	2	DOID:2975 (implicated_via_orthology)
Disease	intellectual disability (implicated_via_orthology)	ZNF280A ZC3H14 ANK2	4.40e-04	75	58	3	DOID:1059 (implicated_via_orthology)
Disease	preterm premature rupture of the membranes, spontaneous preterm birth	TTC21B VGLL4	1.39e-03	28	58	2	EFO_0006917, MONDO_0012511
Disease	Hematopoetic Myelodysplasia	CFLAR BMI1	1.49e-03	29	58	2	C2713368
Disease	amyotrophic lateral sclerosis (implicated_via_orthology)	TARDBP ZNF106	1.59e-03	30	58	2	DOID:332 (implicated_via_orthology)
Disease	Amyotrophic Lateral Sclerosis, Guam Form	TARDBP TRPM7	1.70e-03	31	58	2	C0543859
Disease	internet addiction disorder	KCNH7 FMR1	1.93e-03	33	58	2	EFO_0803368
Disease	interleukin 4 measurement	CARMIL1 VGLL4	2.29e-03	36	58	2	EFO_0008184
Disease	Cognition Disorders	FMR1 AFF4	2.55e-03	38	58	2	C0009241
Disease	diabetic nephropathy	KCNH7 TTC21B STAC	3.24e-03	150	58	3	EFO_0000401
Disease	asthma	MAGI1 ZBTB38 ZNF652 MROH7 STAC XRCC6	3.51e-03	751	58	6	MONDO_0004979
Disease	Gastric Adenocarcinoma	TRPM7 MARK1	3.56e-03	45	58	2	C0278701

Protein segments in the cluster

Peptide	Gene	Start	Entry
TGEPNDALRHFNKAR	TTC21B	1036	Q7Z4L5
ANGKAHFNLTDPERA	ZNF280A	231	P59817
SRHPAENGKSNFLNC	B2M	31	P61769
RKNQELAFHSAGDAP	ANKRD30B	1196	Q9BXX2
RLQEQEKGFRHPSNS	CCDC33	896	Q8N5R6
DSVPNFLKNNGDFHR	CRYBG3	2501	Q68DQ2
NSLRRPSAAHNGQKV	FBXO10	916	Q9UK96
FQREQENKSRPHSRG	PPP2R2D	61	Q66LE6
PSEQLRRHQGKNLAS	RAD54L2	81	Q9Y4B4
IHFPDSNRNNQAEKS	BICC1	166	Q9H694
ANEAHNNLGVKRPTS	CAMSAP3	1056	Q9P1Y5
DPSNNFRLHNGRSKE	CFLAR	196	O15519
ERLNSHFSNLSQPRK	DDX25	16	Q9UHL0
SLDKNSGPRNRADNS	ASXL3	1436	Q9C0F0
ADEKSNPNFFEQRHG	AFF4	86	Q9UHB7
FKLGQRNSNPSRHEL	MROH7	161	Q68CQ1
NIDNRTNFDGPSAKR	GON7	81	Q9BXV9
DKRANPNARALNGFT	ANK2	386	Q01484
NNHQDSSASPRKRPG	ATOH8	201	Q96SQ7
GLVRKAPNNRSSHNE	MXD4	46	Q14582
DLRHFLNQRFQKGSP	MAGI1	111	Q96QZ7
SQRSPGNDHTQDKFL	ITPRID1	596	Q6ZRS4
PKNIFRDRHASEDNG	KCNH7	286	Q9NS40
NNLKFARHVEPGNAA	HAGH	226	Q16775
HAKRARQPLSEASNQ	ANLN	36	Q9NQW6
SGNHQSSFANRPRKS	BMI1	301	P35226
NKDTSSFPGRLLQHD	LRRC49	41	Q8IUZ0
SAKNGTPQDRHLFLF	FGD3	381	Q5JSP0
RPFFAHKRGSQDDQS	RFPL4A	251	A6NLU0
RGSHSDFAAILKNQP	MAP3K13	596	O43283
KGNDDHSRTDNRPRN	FMR1	551	Q06787
AVNSHPQRSDKGNEF	GFPT2	101	O94808
RPRQKEAGLSQSHDD	C2CD2L	651	O14523
LKIADEGHPRNSNSN	CTR9	1026	Q6PD62
RPDGHQNNLRSSAYE	KPNB1	516	Q14974
NQKQRRFSDHAGPSI	MARK1	416	Q9P0L2
LHRAFPQAANGSAKD	LYPLA2	151	O95372
DHFSRRGKTLPQQES	CARMIL1	866	Q5VZK9
GNVARSRPQKHQNTF	C9orf85	6	Q96MD7
FHGPSKDERTRNLNR	ERCC6L	176	Q2NKX8
REHRSNSQQGKSPDL	HSF5	561	Q4G112
RPFFAHKRGSQDDQS	RFPL4AL1	251	F8VTS6
NFQEKNQRPTHLAGA	TMEM150B	106	A6NC51
EPKHNSNRQLERSGR	TARDBP	261	Q13148
LTPDKHDNSQGQDFR	NBPF7P	151	P0C2Y1
NAERERLGNSHQPEK	MRE11	346	P49959
NRDFQGHPDLQKDTS	PLK4	501	O00444
DEQAHRLAPKGNQSR	STK36	286	Q9NRP7
PRENRGSFHKSLDQI	CDCA4	151	Q9BXL8
FNPHLNKTANGDCRR	VGLL4	81	Q14135
NEDNPHGNDSAKASR	XRCC6	171	P12956
SSTDRYDQRHAGNKP	ZNF320	121	A2RRD8
DRHKARNQGSEFQPG	STOX1	431	Q6ZVD7
DFRDPAKNINHQGSL	STAC	266	Q99469
DNFPHNQRREGKDVN	TSNAX	16	Q99598
SGNNFNRKAHLTDPQ	ZNF510	341	Q9Y2H8
RSKSPNNEGDVHFSR	ZBTB38	306	Q8NAP3
LFKSEPLNHRGQSED	ZNF652	576	Q9Y2D9
PSNKSNFSRGDERRH	ZC3H14	96	Q6PJT7
NTRKNSFPHSLRNGG	ZNF106	141	Q9H2Y7
PQLRKSHESFGNRAD	TRPM7	556	Q96QT4
TGANRHQRNPFGKAF	ZNF114	216	Q8NC26
HQRNPFGKAFREDGS	ZNF114	221	Q8NC26