Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionGTPase activator activity

ACAP1 ARHGAP26 RGS12 OPHN1 TBC1D4 NF1 TBC1D12 ARHGAP33 ARHGAP19

9.54e-052791319GO:0005096
GeneOntologyMolecularFunctionlactoperoxidase activity

EPX LPO

2.54e-0441312GO:0140825
GeneOntologyMolecularFunctionenzyme regulator activity

ACAP1 KDM5A ARHGAP26 PAPLN GPRC5C NLRP2 RGS12 OPHN1 PPP1R26 PLEKHG1 TBC1D4 NF1 P2RX7 SH3PXD2A TBC1D12 C4A C4B ATP2A3 ARHGAP33 CRB2 ARHGAP19

3.61e-04141813121GO:0030234
GeneOntologyMolecularFunctionenzyme activator activity

ACAP1 ARHGAP26 GPRC5C RGS12 OPHN1 TBC1D4 NF1 P2RX7 SH3PXD2A TBC1D12 ATP2A3 ARHGAP33 ARHGAP19

3.84e-0465613113GO:0008047
GeneOntologyBiologicalProcessgamma-aminobutyric acid secretion

ABAT NF1 P2RX7 GABBR1

6.96e-06201314GO:0014051
GeneOntologyBiologicalProcessgamma-aminobutyric acid transport

ABAT NF1 P2RX7 GABBR1

2.83e-05281314GO:0015812
GeneOntologyBiologicalProcessacid secretion

ABAT CASR NF1 P2RX7 GABBR1

3.08e-05571315GO:0046717
GeneOntologyBiologicalProcessregulation of gamma-aminobutyric acid secretion

ABAT P2RX7 GABBR1

6.84e-05131313GO:0014052
GeneOntologyCellularComponentsomatodendritic compartment

CACNA1B NRDC GPR37 SREBF2 CASR RGS12 OPHN1 MAPK8IP3 FZD4 SLC8A2 NF1 P2RX7 CNTNAP4 C4A C4B CHRNA10 PALLD GABBR1 ARHGAP33

2.35e-04122813119GO:0036477
GeneOntologyCellularComponentdendrite

CACNA1B NRDC GPR37 SREBF2 RGS12 OPHN1 MAPK8IP3 FZD4 SLC8A2 NF1 CNTNAP4 C4A C4B GABBR1 ARHGAP33

3.17e-0485813115GO:0030425
GeneOntologyCellularComponentdendritic tree

CACNA1B NRDC GPR37 SREBF2 RGS12 OPHN1 MAPK8IP3 FZD4 SLC8A2 NF1 CNTNAP4 C4A C4B GABBR1 ARHGAP33

3.25e-0486013115GO:0097447
GeneOntologyCellularComponentglutamatergic synapse

CACNA1B VPS18 DGKB CASR GRIN2D CBLB OPHN1 FZD4 NF1 CELSR3 GUCY1A1 SCN2A GABBR1 ARHGAP33

6.17e-0481713114GO:0098978
GeneOntologyCellularComponentextracellular matrix

COL4A6 FBLN7 ITGA6 PAPLN LAMC3 LRIG3 FREM2 CSPG4 SEMA3B MMP9 ADAMTSL2 OTOG

8.74e-0465613112GO:0031012
GeneOntologyCellularComponentexternal encapsulating structure

COL4A6 FBLN7 ITGA6 PAPLN LAMC3 LRIG3 FREM2 CSPG4 SEMA3B MMP9 ADAMTSL2 OTOG

8.97e-0465813112GO:0030312
GeneOntologyCellularComponentbasement membrane

COL4A6 ITGA6 PAPLN LAMC3 FREM2

1.03e-031221315GO:0005604
GeneOntologyCellularComponentsymbiont cell surface

C4A C4B

1.06e-0381312GO:0106139
DomainRho_GTPase_activation_prot

INPP5B ARHGAP26 OPHN1 NF1 ARHGAP33 ARHGAP19

3.44e-05881306IPR008936
DomainRhoGAP

INPP5B ARHGAP26 OPHN1 ARHGAP33 ARHGAP19

7.12e-05621305SM00324
DomainRhoGAP

INPP5B ARHGAP26 OPHN1 ARHGAP33 ARHGAP19

7.69e-05631305PF00620
DomainRhoGAP_dom

INPP5B ARHGAP26 OPHN1 ARHGAP33 ARHGAP19

8.30e-05641305IPR000198
DomainRHOGAP

INPP5B ARHGAP26 OPHN1 ARHGAP33 ARHGAP19

8.30e-05641305PS50238
Domain-

INPP5B ARHGAP26 OPHN1 ARHGAP33 ARHGAP19

8.30e-056413051.10.555.10
DomainLAM_G_DOMAIN

CELSR3 CSPG4 CNTNAP4 CRB2

1.38e-04381304PS50025
DomainLaminin_G_2

CELSR3 CSPG4 CNTNAP4 CRB2

1.69e-04401304PF02210
DomainLamG

CELSR3 CSPG4 CNTNAP4 CRB2

2.45e-04441304SM00282
Domain7tm_3

CASR GPRC5C GABBR1

4.61e-04221303PF00003
DomainG_PROTEIN_RECEP_F3_2

CASR GPRC5C GABBR1

4.61e-04221303PS00980
DomainG_PROTEIN_RECEP_F3_3

CASR GPRC5C GABBR1

4.61e-04221303PS00981
DomainG_PROTEIN_RECEP_F3_1

CASR GPRC5C GABBR1

4.61e-04221303PS00979
DomainG_PROTEIN_RECEP_F3_4

CASR GPRC5C GABBR1

4.61e-04221303PS50259
DomainGPCR_3_C

CASR GPRC5C GABBR1

4.61e-04221303IPR017978
DomainAnaphylatoxin_comp_syst

C4A C4B

4.74e-0451302IPR018081
DomainAnaphylatoxn_comp_syst_dom

C4A C4B

4.74e-0451302IPR001840
DomainRDM_domain_RFPL

RFPL1 RFPL3

4.74e-0451302IPR022723
DomainRDM

RFPL1 RFPL3

4.74e-0451302PF11002
DomainPEROXIDASE_1

EPX LPO

7.08e-0461302PS00435
DomainLaminin_G

CELSR3 CSPG4 CNTNAP4 CRB2

7.11e-04581304IPR001791
DomainANATO

C4A C4B

9.87e-0471302SM00104
DomainANAPHYLATOXIN_2

C4A C4B

9.87e-0471302PS01178
DomainANAPHYLATOXIN_1

C4A C4B

9.87e-0471302PS01177
DomainANATO

C4A C4B

9.87e-0471302PF01821
DomainAnaphylatoxin/fibulin

C4A C4B

9.87e-0471302IPR000020
DomainMacrogloblnA2_thiol-ester-bond

C4A C4B

1.31e-0381302IPR019565
DomainCalx_beta

FREM2 SLC8A2

1.31e-0381302SM00237
DomainThiol-ester_cl

C4A C4B

1.31e-0381302PF10569
DomainMacrogloblnA2_CS

C4A C4B

1.31e-0381302IPR019742
DomainCalx_beta

FREM2 SLC8A2

1.68e-0391302IPR003644
DomainCalx-beta

FREM2 SLC8A2

1.68e-0391302PF03160
DomainEGF-like_dom

FBLN7 LAMC3 VWCE CELSR3 CNTNAP4 CRB2 OTOG

1.81e-032491307IPR000742
DomainJmjN

KDM5A KDM4E

2.09e-03101302SM00545
DomainAn_peroxidase

EPX LPO

2.09e-03101302PF03098
DomainA2M

C4A C4B

2.09e-03101302PF00207
DomainA2M_N_2

C4A C4B

2.09e-03101302IPR011625
DomainA2M_comp

C4A C4B

2.09e-03101302IPR011626
DomainHaem_peroxidase_animal

EPX LPO

2.09e-03101302IPR019791
DomainJmjN

KDM5A KDM4E

2.09e-03101302PF02375
DomainA2M_recep

C4A C4B

2.09e-03101302PF07677
DomainA2M_comp

C4A C4B

2.09e-03101302PF07678
DomainA2M_N

C4A C4B

2.09e-03101302PF01835
DomainA2M_N

C4A C4B

2.09e-03101302IPR002890
DomainA-macroglobulin_rcpt-bd

C4A C4B

2.09e-03101302IPR009048
DomainHaem_peroxidase

EPX LPO

2.09e-03101302IPR010255
DomainALPHA_2_MACROGLOBULIN

C4A C4B

2.09e-03101302PS00477
DomainJMJN

KDM5A KDM4E

2.09e-03101302PS51183
DomainPEROXIDASE_3

EPX LPO

2.09e-03101302PS50292
DomainA2M_N_2

C4A C4B

2.09e-03101302PF07703
DomainJmjN

KDM5A KDM4E

2.09e-03101302IPR003349
Domain-

EPX LPO

2.09e-031013021.10.640.10
DomainMacroglobln_a2

C4A C4B

2.09e-03101302IPR001599
DomainANF_lig-bd_rcpt

CASR GRIN2D GABBR1

2.15e-03371303IPR001828
DomainANF_receptor

CASR GRIN2D GABBR1

2.15e-03371303PF01094
DomainPeripla_BP_I

CASR GRIN2D GABBR1

2.51e-03391303IPR028082
DomainVWF_dom

AMN VWCE OTOG

3.10e-03421303IPR001007
DomainI-BAR_dom

ARHGAP26 OPHN1

3.57e-03131302IPR013606
DomainEF-hand_6

MYL9 MYL12B

3.57e-03131302PF13405
DomainDynein_heavy_chain_D4_dom

DNAH12 DNAH6

4.14e-03141302IPR024317
DomainDynein_heavy_dom-2

DNAH12 DNAH6

4.14e-03141302IPR013602
DomainDHC_N2

DNAH12 DNAH6

4.14e-03141302PF08393
DomainATPase_dyneun-rel_AAA

DNAH12 DNAH6

4.14e-03141302IPR011704
DomainPLAC

PAPLN ADAMTSL2

4.14e-03141302PF08686
DomainAAA_8

DNAH12 DNAH6

4.14e-03141302PF12780
DomainAAA_5

DNAH12 DNAH6

4.14e-03141302PF07728
DomainConA-like_dom

RFPL1 CELSR3 CSPG4 CNTNAP4 RFPL3 CRB2

4.34e-032191306IPR013320
Domain-

CELSR3 CSPG4 CNTNAP4 CRB2

4.38e-039513042.60.120.200
DomainDHC_fam

DNAH12 DNAH6

4.76e-03151302IPR026983
DomainDynein_heavy

DNAH12 DNAH6

4.76e-03151302PF03028
DomainDynein_heavy_dom

DNAH12 DNAH6

4.76e-03151302IPR004273
DomainASX_HYDROXYL

FBLN7 VWCE CELSR3 CRB2

5.25e-031001304PS00010
DomainSushi

FBLN7 CSMD3 GABBR1

5.68e-03521303PF00084
DomainEGF

FBLN7 LAMC3 VWCE CELSR3 CNTNAP4 CRB2

6.08e-032351306SM00181
DomainEGF_3

FBLN7 VWCE CELSR3 CNTNAP4 CRB2 OTOG

6.08e-032351306PS50026
DomainC345C

C4A C4B

6.11e-03171302SM00643
DomainCCP

FBLN7 CSMD3 GABBR1

6.31e-03541303SM00032
DomainEGF-type_Asp/Asn_hydroxyl_site

FBLN7 VWCE CELSR3 CRB2

6.44e-031061304IPR000152
DomainTerpenoid_cyclase/PrenylTrfase

C4A C4B

6.84e-03181302IPR008930
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

POLE RPS6KA2 ARHGAP26 PAPLN LAMC3 CEP192 GRIN2D MAPK8IP3 PPP1R26 PLEKHG1 WIZ CELSR3 TULP4 IER5L TMEM259 CSPG4 HELZ2 ATP2A3 ARHGAP33 BAHCC1

8.49e-0911051332035748872
Pubmed

FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.

NOP56 GPR37 EXPH5 DHX57 PTPN22 RGS12 DNAH12 C4A C4B ATP2A3 TBL2

3.58e-064971331136774506
Pubmed

Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.

ACAP1 ABAT GRIN2D EPX CELSR3 P2RX7 TULP4 ATP2A3 GABBR1

5.30e-06329133917474147
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

KDM5A EXPH5 RPS6KA2 CEP192 RGS12 PLEKHG1 LSR TBC1D4 NF1 MAST4 SH3PXD2A PALLD OTOG ARHGAP19

5.89e-068611331436931259
Pubmed

Copy number analysis of complement C4A, C4B and C4A silencing mutation by real-time quantitative polymerase chain reaction.

C4A C4B

1.45e-052133222737222
Pubmed

Deficiency of C4 from donor or recipient mouse fails to prevent renal allograft rejection.

C4A C4B

1.45e-052133216565498
Pubmed

Complete deficiencies of complement C4A and C4B including 2-bp insertion in codon 1213 are genetic risk factors of systemic lupus erythematosus in Thai populations.

C4A C4B

1.45e-052133215998580
Pubmed

High-throughput analysis of the C4 polymorphism by a combination of MLPA and isotype-specific ELISA's.

C4A C4B

1.45e-052133219062096
Pubmed

Rapid ATP-induced release of matrix metalloproteinase 9 is mediated by the P2X7 receptor.

P2RX7 MMP9

1.45e-052133216514055
Pubmed

Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice.

C4A C4B

1.45e-052133219933335
Pubmed

Structural basis for the C4d.1/C4d.2 serologic allotypes of murine complement component C4.

C4A C4B

1.45e-05213322459207
Pubmed

Antigen-induced B cell apoptosis is independent of complement C4.

C4A C4B

1.45e-052133217645767
Pubmed

Anti-DNA autoreactivity in C4-deficient mice.

C4A C4B

1.45e-052133212207352
Pubmed

Complement C4A and C4B Gene Copy Number Study in Alzheimer's Disease Patients.

C4A C4B

1.45e-052133227758680
Pubmed

Genetically determined partial complement C4 deficiency states are not independent risk factors for SLE in UK and Spanish populations.

C4A C4B

1.45e-052133222387014
Pubmed

Complement C4 maintains peripheral B-cell tolerance in a myeloid cell dependent manner.

C4A C4B

1.45e-052133223749435
Pubmed

Copy number variations of complement component C4 are associated with Behçet's disease but not with ankylosing spondylitis associated with acute anterior uveitis.

C4A C4B

1.45e-052133223918728
Pubmed

Molecular genetics of androgen-dependent and -independent expression of mouse sex-limited protein.

C4A C4B

1.45e-05213323037333
Pubmed

Evidence of a role for C4 in modulating interstitial inflammation in experimental glomerulonephritis.

C4A C4B

1.45e-052133211726230
Pubmed

Quantitative variations in the expression of the mouse serum antigen Ss and its sex-limited allotype Slp.

C4A C4B

1.45e-05213324216347
Pubmed

Sequence determination of the thiolester site of the fourth component of human complement.

C4A C4B

1.45e-05213326950384
Pubmed

Visual demonstration of the organization of the human complement C4 and 21-hydroxylase genes by high-resolution fluorescence in situ hybridization.

C4A C4B

1.45e-05213328660986
Pubmed

Tissue-specific RNA processing for the complement C4 gene transcript in the H-2k mouse strain.

C4A C4B

1.45e-05213328428773
Pubmed

Complement C4 deficiency--a plausible risk factor for non-tuberculous mycobacteria (NTM) infection in apparently immunocompetent patients.

C4A C4B

1.45e-052133224638111
Pubmed

Transcriptional repression of C4 complement by hepatitis C virus proteins.

C4A C4B

1.45e-052133221345967
Pubmed

Restriction fragment analysis of H-2 recombinant mouse strains with crossovers between E alpha and C4 genes.

C4A C4B

1.45e-05213322572548
Pubmed

The complement component C4 of mammals.

C4A C4B

1.45e-05213322302180
Pubmed

Gene CNVs and protein levels of complement C4A and C4B as novel biomarkers for partial disease remissions in new-onset type 1 diabetes patients.

C4A C4B

1.45e-052133222151770
Pubmed

C4d-positive chronic rejection: a frequent entity with a poor outcome.

C4A C4B

1.45e-052133218091514
Pubmed

Comprehensive approach to study complement C4 in systemic lupus erythematosus: Gene polymorphisms, protein levels and functional activity.

C4A C4B

1.45e-052133229080553
Pubmed

Genes for murine fourth complement component (C4) and sex-limited protein (Slp) identified by hybridization to C4- and Slp-specific cDNA.

C4A C4B

1.45e-05213326589636
Pubmed

C4 Deficiency is a predisposing factor for Streptococcus pneumoniae-induced autoantibody production.

C4A C4B

1.45e-052133225339671
Pubmed

A study of association of the complement C4 mutations with systemic lupus erythematosus in the Malaysian population.

C4A C4B

1.45e-052133217728371
Pubmed

Structure and organization of the C4 genes.

C4A C4B

1.45e-05213326149580
Pubmed

Sequence heterogeneity of murine complementary DNA clones related to the C4 and C4-Slp isoforms of the fourth complement component.

C4A C4B

1.45e-05213326149581
Pubmed

The follicular dendritic cell restricted epitope, FDC-M2, is complement C4; localization of immune complexes in mouse tissues.

C4A C4B

1.45e-052133212115608
Pubmed

Biochemistry and biology of anaphylatoxins.

C4A C4B

1.45e-05213323542363
Pubmed

C4 from C4-high and C4-low mouse strains have identical sequences in the region corresponding to the isotype-specific segment of human C4.

C4A C4B

1.45e-05213322387317
Pubmed

Identification of the size and antigenic determinants of the human C4 gene by a polymerase chain-reaction-based amplification method.

C4A C4B

1.45e-052133216908004
Pubmed

Structural studies on the murine fourth component of complement (C4). IV. Demonstration that C4 and Slp are encoded by separate loci.

C4A C4B

1.45e-05213327365238
Pubmed

Interaction between the labile binding sites of the fourth (C4) and fifth (C5) human complement proteins and erythrocyte cell membranes.

C4A C4B

1.45e-05213327391573
Pubmed

Peritubular capillary C4d deposition in lupus nephritis different from antibody-mediated renal rejection.

C4A C4B

1.45e-052133217971360
Pubmed

Clinical features of patients with homozygous complement C4A or C4B deficiency.

C4A C4B

1.45e-052133229928053
Pubmed

Analysis of C4 and the C4 binding protein in the MRL/lpr mouse.

C4A C4B

1.45e-052133217971229
Pubmed

Genetic deficiency of C4 presenting with recurrent infections and a SLE-like disease. Genetic and immunologic studies.

C4A C4B

1.45e-05213326881182
Pubmed

Partial C4 deficiency in juvenile idiopathic arthritis patients.

C4A C4B

1.45e-052133217921792
Pubmed

Complement activation and complement receptors on follicular dendritic cells are critical for the function of a targeted adjuvant.

C4A C4B

1.45e-052133221880985
Pubmed

Amino acid sequence around the thiol and reactive acyl groups of human complement component C4.

C4A C4B

1.45e-05213326978711
Pubmed

Plasma Complement 3 and Complement 4 Are Promising Biomarkers for Distinguishing NMOSD From MOGAD and Are Associated With the Blood-Brain-Barrier Disruption in NMOSD.

C4A C4B

1.45e-052133235898513
Pubmed

Borrelia burgdorferi outer surface protein C (OspC) binds complement component C4b and confers bloodstream survival.

C4A C4B

1.45e-052133228873507
Pubmed

Studies on the murine Ss protein: demonstration that the Ss protein is functionally the fourth component of complement.

C4A C4B

1.45e-0521332276882
Pubmed

Amino acid sequence of a polymorphic segment from fragment C4d of human complement component C4.

C4A C4B

1.45e-05213326832377
Pubmed

Recombination of two homologous MHC class III genes of the mouse (C4 and Slp) that accounts for the loss of testosterone dependence of sex-limited protein expression.

C4A C4B

1.45e-05213323794341
Pubmed

Fine-tuned characterization of RCCX copy number variants and their relationship with extended MHC haplotypes.

C4A C4B

1.45e-052133222785613
Pubmed

Association between complement 4 copy number variation and systemic lupus erythematosus: a meta-analysis.

C4A C4B

1.45e-052133232691186
Pubmed

The androgen-dependent C4-Slp gene is driven by a constitutively competent promoter.

C4A C4B

1.45e-05213328390682
Pubmed

Structure and expression of murine fourth complement component (C4) and sex-limited protein (Slp).

C4A C4B

1.45e-05213323902619
Pubmed

Structural polymorphism of murine C4 and its linkage to H-2.

C4A C4B

1.45e-05213327373044
Pubmed

The chemical structure of the C4d fragment of the human complement component C4.

C4A C4B

1.45e-05213323696167
Pubmed

Restriction fragment length polymorphism of the murine C4 and Slp genes: two C4 groups.

C4A C4B

1.45e-05213321357031
Pubmed

Ptpn22 Modifies Regulatory T Cell Homeostasis via GITR Upregulation.

PTPN22 TNFRSF18

1.45e-052133226810223
Pubmed

Structural comparison of human C4A3 and C4B1 after proteolytic activation by C1s.

C4A C4B

1.45e-052133216098595
Pubmed

Increased frequency of C4B*Q0 alleles in patients with Henoch-Schönlein purpura.

C4A C4B

1.45e-052133215787745
Pubmed

Glucocorticoid-induced tumour necrosis factor receptor expression: a potential molecular link between steroid intake and complicated diverticulitis?

TNFRSF18 MMP9

1.45e-052133222309286
Pubmed

Neuropil contraction in relation to Complement C4 gene copy numbers in independent cohorts of adolescent-onset and young adult-onset schizophrenia patients-a pilot study.

C4A C4B

1.45e-052133230026462
Pubmed

A molecular map of the human major histocompatibility complex class III region linking complement genes C4, C2 and factor B.

C4A C4B

1.45e-05213326559257
Pubmed

Complement C4 Is Reduced in iPSC-Derived Astrocytes of Autism Spectrum Disorder Subjects.

C4A C4B

1.45e-052133234299197
Pubmed

Assessment of complement C4 gene copy number using the paralog ratio test.

C4A C4B

1.45e-052133220506482
Pubmed

Polymerase chain reaction based C4AQ0 and C4BQ0 genotyping: association with systemic lupus erythematosus in southwest Han Chinese.

C4A C4B

1.45e-052133212480675
Pubmed

Low C4, C4A and C4B gene copy numbers are stronger risk factors for juvenile-onset than for adult-onset systemic lupus erythematosus.

C4A C4B

1.45e-052133226800705
Pubmed

Murine complement C4 is not required for experimental autoimmune encephalomyelitis.

C4A C4B

1.45e-052133215390104
Pubmed

N-type calcium current, Cav2.2, is enhanced in small-diameter sensory neurons isolated from Nf1+/- mice.

CACNA1B NF1

1.45e-052133224755485
Pubmed

Importance of the alpha 3-fragment of complement C4 for the binding with C4b-binding protein.

C4A C4B

1.45e-05213321699796
Pubmed

Molecular cloning and characterization of complementary and genomic DNA clones for mouse C4 and Slp.

C4A C4B

1.45e-05213322997024
Pubmed

Constitutive expression of Slp genes in mouse strain B10.WR directed by C4 regulatory sequences.

C4A C4B

1.45e-05213323624865
Pubmed

Determination of the loss of function complement C4 exon 29 CT insertion using a novel paralog-specific assay in healthy UK and Spanish populations.

C4A C4B

1.45e-052133221857912
Pubmed

Tyrosine-kinase-dependent recruitment of RGS12 to the N-type calcium channel.

CACNA1B RGS12

1.45e-052133211130074
Pubmed

Isolation of cDNA clones specifying the fourth component of mouse complement and its isotype, sex-limited protein.

C4A C4B

1.45e-05213326208559
Pubmed

The role of the histocompatibility-2-linked Ss-Slp region in the control of mouse complement.

C4A C4B

1.45e-05213324514997
Pubmed

The inheritance of susceptibility to the Gross leukemia virus in mice.

C4A C4B

1.45e-05213325919331
Pubmed

An ancient provirus has imposed androgen regulation on the adjacent mouse sex-limited protein gene.

C4A C4B

1.45e-05213323167981
Pubmed

The dichotomous size variation of human complement C4 genes is mediated by a novel family of endogenous retroviruses, which also establishes species-specific genomic patterns among Old World primates.

C4A C4B

1.45e-05213327545960
Pubmed

Insights on the relationship between complement component C4 serum concentrations and C4 gene copy numbers in a Western Australian systemic lupus erythematosus cohort.

C4A C4B

1.45e-052133230041577
Pubmed

Complete cDNA sequence of the fourth component of murine complement.

C4A C4B

1.45e-05213323862104
Pubmed

The BS variant of C4 protects against age-related loss of white matter microstructural integrity.

C4A C4B

1.45e-052133234358307
Pubmed

Acute renal allograft rejection: diagnostic significance of focal peritubular capillary C4d.

C4A C4B

1.45e-052133218360261
Pubmed

Schizophrenia risk from complex variation of complement component 4.

C4A C4B

1.45e-052133226814963
Pubmed

Promoter elements of the mouse complement C4 gene critical for transcription activation and start site location.

C4A C4B

1.45e-05213328132550
Pubmed

Substitution of a single amino acid (aspartic acid for histidine) converts the functional activity of human complement C4B to C4A.

C4A C4B

1.45e-05213322395880
Pubmed

Effects of Complement C4 Gene Copy Number Variations, Size Dichotomy, and C4A Deficiency on Genetic Risk and Clinical Presentation of Systemic Lupus Erythematosus in East Asian Populations.

C4A C4B

1.45e-052133226814708
Pubmed

cDNA clone spanning the alpha-gamma subunit junction in the precursor of the murine fourth complement component (C4).

C4A C4B

1.45e-05213326192448
Pubmed

Complete primary structure of human C4a anaphylatoxin.

C4A C4B

1.45e-05213326167582
Pubmed

Slp is an essential component of an EDTA-resistant activation pathway of mouse complement.

C4A C4B

1.45e-05213321438267
Pubmed

Type B gamma-aminobutyric acid receptors modulate the function of the extracellular Ca2+-sensing receptor and cell differentiation in murine growth plate chondrocytes.

CASR GABBR1

1.45e-052133217615148
Pubmed

Genetic deficiency of complement isoforms C4A or C4B predicts improved survival of metastatic renal cell carcinoma.

C4A C4B

1.45e-052133219150565
Pubmed

Elevated levels of endogenous apoptotic DNA and IFN-alpha in complement C4-deficient mice: implications for induction of systemic lupus erythematosus.

C4A C4B

1.45e-052133217506029
Pubmed

Low C4 gene copy numbers are associated with superior graft survival in patients transplanted with a deceased donor kidney.

C4A C4B

1.45e-052133223715124
Pubmed

Identification of the 5'-flanking regulatory region responsible for the difference in transcriptional control between mouse complement C4 and Slp genes.

C4A C4B

1.45e-05213323464002
Pubmed

Complete nucleotide and derived amino acid sequences of the fourth component of mouse complement (C4). Evolutionary aspects.

C4A C4B

1.45e-05213322993295
Pubmed

Identification of the site of sulfation of the fourth component of human complement.

C4A C4B

1.45e-05213323944109
GeneFamilyRho GTPase activating proteins|BCH domain containing

ARHGAP26 OPHN1 ARHGAP33 ARHGAP19

1.06e-0450894721
GeneFamilyADAMTS like

PAPLN ADAMTSL2

4.95e-047892947
GeneFamilyPeptide receptors

MLNR KISS1R

4.95e-047892220
GeneFamilyC3 and PZP like, alpha-2-macroglobulin domain containing

C4A C4B

8.43e-0498921234
GeneFamilyMyosin light chains|EF-hand domain containing

MYL9 MYL12B

2.10e-0314892657
GeneFamilyHyalectan proteoglycans|V-set domain containing|Sushi domain containing|C-type lectin domain containing

FBLN7 CSMD3 GABBR1

2.78e-03578931179
GeneFamilyDyneins, axonemal

DNAH12 DNAH6

3.11e-0317892536
GeneFamilyX-linked mental retardation|Rho GTPase activating proteins|BAR-PH domain containing

ACAP1 OPHN1

3.11e-03178921291
CoexpressionAtlasdev lower uro neuro_e15.5_PelvicGanglion_Sox10_k-means-cluster#2_top-relative-expression-ranked_1000

CACNA1B NOP56 DGKB CHD7 CSMD3 SCN2A GABBR1

1.45e-06911307gudmap_dev lower uro neuro_e15.5_PelvicGanglion_Sox10_k2_1000
ToppCellfacs-Heart-LV-3m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

INPP5B DGKB GPRC5C SLC8A2 MYL9 GUCY1A1 CSPG4 PALLD

6.88e-0817913388da6863edc756540bb097cc7221c1408640d9bb4
ToppCellfacs-Heart-LV-3m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

INPP5B DGKB GPRC5C SLC8A2 MYL9 GUCY1A1 CSPG4 PALLD

6.88e-081791338f39c13c99a07d009cc677e363ffe089089c64916
ToppCelldroplet-Bladder-BLADDER-1m-Hematologic-nan|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACAP1 BEND3 PTPN22 TNFRSF18 LIN9 P2RX7 ASF1B ATP2A3

8.88e-081851338969248b63d4ce335f223528de756bcddffadbd77
ToppCelldroplet-Kidney-nan-3m-Epithelial-Stroma____kidney_mesangial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBLN7 DGKB SLC8A2 MYL9 GUCY1A1 CSPG4 DACT3 PALLD

1.05e-071891338a959c9d6a0866582688a4204d625c1e5a123e93d
ToppCellfacs-Brain_Non-Myeloid-Cortex-3m-Endothelial-Endothelial_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGA6 HSPA12B RGS12 KLF2 FZD4 LSR TBC1D4 ADAMTSL2

1.18e-0719213389ae05db5bfb8b9d3935c0328e6f2d489d2b1ebfd
ToppCellfacs-Brain_Non-Myeloid-Cortex-3m-Endothelial|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGA6 HSPA12B RGS12 KLF2 FZD4 LSR TBC1D4 ADAMTSL2

1.18e-071921338a116db7dec495e5a0ba9c7537057cd1e567d7885
ToppCellfacs-Brain_Non-Myeloid-Cortex-3m-Endothelial-endothelial_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGA6 HSPA12B RGS12 KLF2 FZD4 LSR TBC1D4 ADAMTSL2

1.18e-07192133866defad13bd8e79319741e43ddb056841710b1d7
ToppCellfacs-Brain_Non-Myeloid-Cortex-3m-Mesenchymal-Pericyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL4A6 DGKB GPRC5C MYL9 GUCY1A1 CSPG4 ATP2A3 PALLD

1.28e-071941338bf34737ae2dc218f890fbb9201c308b324415749
ToppCellfacs-Brain_Non-Myeloid-Cortex-3m-Mesenchymal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL4A6 DGKB GPRC5C MYL9 GUCY1A1 CSPG4 ATP2A3 PALLD

1.28e-071941338b35e33439b6d3b5d69147e617224d2c8fd056223
ToppCellfacs-Brain_Non-Myeloid-Cortex-3m-Mesenchymal-brain_pericyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL4A6 DGKB GPRC5C MYL9 GUCY1A1 CSPG4 ATP2A3 PALLD

1.28e-0719413384ebed7a6731b88c8359860072cbeba355a7e90ac
ToppCelldroplet-Liver-Hepatocytes-18m-Myeloid-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RBM12B OPHN1 MAST4 IER5L DACT3 ARHGAP19

5.02e-0798133695162072f3afc95e46f29db3d79ebd930bc09726
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Mesenchymal-brain_pericyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL4A6 DGKB GPRC5C MYL9 GUCY1A1 CSPG4 ATP2A3

9.11e-0717313372415b6ff49f334da570577d4e93484d024a3dbd5
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Mesenchymal-Pericyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL4A6 DGKB GPRC5C MYL9 GUCY1A1 CSPG4 ATP2A3

9.11e-0717313372acd0693a2dfe04e3c1b2125ea63efe92d13150b
ToppCell356C-Lymphocytic-CD4_T-cell-Treg_cell_2|356C / Donor, Lineage, Cell class and subclass (all cells)

FBLN7 ACAP1 TNFRSF18 LIN9 TBC1D4 ZSCAN16 GFPT2

1.10e-0617813378b939659f713eea50a1a6e28b571f680ca0b4c12
ToppCellfacs-Heart-RV-3m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DGKB GPRC5C FREM2 MYL9 GUCY1A1 CSPG4 PALLD

1.19e-0618013370059e5acade6c895fd629767bea1c15f40b0d1b0
ToppCellfacs-Heart-RV-3m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DGKB GPRC5C FREM2 MYL9 GUCY1A1 CSPG4 PALLD

1.19e-061801337dfb8412e1e06fa7349e66eea2ef27d9ea98b7893
ToppCelldroplet-Kidney-nan-18m-Epithelial-Stroma____kidney_mesangial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DGKB CSMD3 MYL9 GUCY1A1 CSPG4 DACT3 PALLD

1.19e-061801337b6f44fdedc33b7d93b0074e8e9c8cc32009d4c4d
ToppCelldroplet-Kidney-KIDNEY-30m-Epithelial-Stroma____kidney_mesangial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBLN7 DGKB LAMC3 MYL9 GUCY1A1 CSPG4 DACT3

1.33e-0618313378de4b616a06be03e1cb6ae6a9ce6bf06485629d3
ToppCellfacs-Brain_Non-Myeloid-Striatum-3m-Mesenchymal-brain_pericyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DGKB GPRC5C MYL9 GUCY1A1 CSPG4 ATP2A3 PALLD

1.38e-06184133789ae8bf1a6c2d355d279d23a5e24a08d9ec2334e
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Mesenchymal-Pericyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMC3 GPRC5C MYL9 GUCY1A1 CSPG4 ATP2A3 PALLD

1.38e-06184133794748f63947db79a6b4540e3090a63689fdd9452
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Mesenchymal-brain_pericyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMC3 GPRC5C MYL9 GUCY1A1 CSPG4 ATP2A3 PALLD

1.38e-061841337819b277ecced7b415e363c7e7ddbc6f3b2d296de
ToppCellfacs-Brain_Non-Myeloid-Striatum-3m-Mesenchymal-Pericyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DGKB GPRC5C MYL9 GUCY1A1 CSPG4 ATP2A3 PALLD

1.38e-06184133734c84ac9a32eaf96f45b79485119cad65905817d
ToppCellfacs-Brain_Non-Myeloid-Cortex_-18m-Endothelial-Endothelial_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGA6 FNBP1L HSPA12B RGS12 KLF2 LSR MYL12B

1.48e-061861337a58c9d1567da0961e0e295a156773d2252ee5a1a
ToppCelldroplet-Kidney-nan-18m-Epithelial-kidney_mesangial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DGKB CSMD3 MYL9 GUCY1A1 CSPG4 DACT3 PALLD

1.59e-061881337d1a4cd4db95d8d32b79156290f7867f32824cc87
ToppCell3'-Adult-Distal_Rectal-Mesenchymal-Pericytes|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DGKB PERM1 MYL9 GUCY1A1 CSPG4 DACT3 PALLD

1.64e-061891337d69b7a01dd4d6ad043bb6210e9ab34b49578389c
ToppCell3'-Adult-Distal_Rectal-Mesenchymal-Pericytes-Contractile_pericyte_(PLN+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DGKB PERM1 MYL9 GUCY1A1 CSPG4 DACT3 PALLD

1.64e-0618913372b5f1b4f173a224342ea4f10b193ee33b7662699
ToppCell3'-Adult-Distal_Rectal-Mesenchymal|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DGKB PERM1 MYL9 GUCY1A1 CSPG4 DACT3 PALLD

1.64e-06189133743e131458d8a4b120f7a5fb3d0c5650abded15f6
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-3m-Mesenchymal-Pericyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMC3 GPRC5C MYL9 GUCY1A1 CSPG4 ATP2A3 PALLD

1.76e-061911337cb75e6c36dbe2e091e407d691c063ec7c4fd5f90
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-3m-Mesenchymal-brain_pericyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMC3 GPRC5C MYL9 GUCY1A1 CSPG4 ATP2A3 PALLD

1.76e-061911337b2cffea7860dd590b505ee0ebd51aa1978cb5e64
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Endothelial-Endothelial_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGA6 FNBP1L HSPA12B RGS12 KLF2 LSR TBC1D4

1.83e-0619213379d53b42cdb537b30233cdfdc08052c8b13a1113f
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Endothelial-endothelial_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGA6 FNBP1L HSPA12B RGS12 KLF2 LSR TBC1D4

1.83e-061921337042391162df2e3d0027688dd14163c4c6821afe0
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Endothelial|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGA6 FNBP1L HSPA12B RGS12 KLF2 LSR TBC1D4

1.83e-06192133771b0bfee0461ff64cef35881db3959c517e9731b
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-3m-Mesenchymal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMC3 GPRC5C MYL9 GUCY1A1 CSPG4 ATP2A3 PALLD

1.83e-061921337e5117cdb8af220f60bd1410262078c0306667b4a
ToppCelldroplet-Heart-HEART_(LV+RV_ONLY)-30m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DGKB GPRC5C SLC8A2 MYL9 GUCY1A1 CSPG4 PALLD

1.89e-0619313371043b28503bfaa0d5a82ec358bc86cbde73ea8f2
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-3m-Endothelial-Endothelial_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGA6 FNBP1L HSPA12B RGS12 KLF2 LSR TBC1D4

1.89e-061931337e4b440d50ae7391b26924778be6d9d53e0692449
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-3m-Endothelial|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGA6 FNBP1L HSPA12B RGS12 KLF2 LSR TBC1D4

1.89e-061931337e523dc5751f6fdcd4fc1a62b1eecd43f6ae79da9
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-3m-Endothelial-endothelial_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGA6 FNBP1L HSPA12B RGS12 KLF2 LSR TBC1D4

1.89e-0619313371772f2ac217727de63c4a9303881b3a19a6bb0f0
ToppCelldroplet-Heart-HEART_(LV+RV_ONLY)-30m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DGKB GPRC5C SLC8A2 MYL9 GUCY1A1 CSPG4 PALLD

1.89e-0619313370266a4fdf436d83ec1d9392abba8c6ec5166970a
ToppCellfacs-Brain_Non-Myeloid-Hippocampus_-18m-Mesenchymal-Pericyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DGKB GPRC5C MYL9 GUCY1A1 CSPG4 ATP2A3 PALLD

1.96e-0619413373bff2e4eb16719ab7419b2f94c9c6e7302aa6629
ToppCellfacs-Brain_Non-Myeloid-Hippocampus_-18m-Mesenchymal-brain_pericyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DGKB GPRC5C MYL9 GUCY1A1 CSPG4 ATP2A3 PALLD

1.96e-061941337fdaf61cbe7f77ff5358d150b38adb1fe3778e961
ToppCellSevere-Lymphoid-T-Treg|Severe / Condition, Lineage, Cell class and cell subclass

FBLN7 ACAP1 PTPN22 TNFRSF18 CBLB TBC1D4 MAST4

2.09e-06196133729d4db6816fead2ad9136ef824e0775463b02159
ToppCellmedial-2-Endothelial-Capillary_Intermediate_1|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

EXPH5 ITGA6 FNBP1L HSPA12B OPHN1 FZD4 PLEKHG1

2.39e-062001337a8adf5902540f6bb15b72efbb9c389b59d67e001
ToppCellmedial-Endothelial-Capillary_Intermediate_1|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

EXPH5 ITGA6 FNBP1L HSPA12B OPHN1 FZD4 PLEKHG1

2.39e-0620013373ef7b7728615710c691aed8977e2582f19692cf9
ToppCellmedial-Endothelial-Capillary_Intermediate_1-2|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

EXPH5 ITGA6 FNBP1L HSPA12B OPHN1 FZD4 PLEKHG1

2.39e-062001337707148e01e961097819a05437a842b7d3bf72b0a
ToppCellTCGA-Breast-Primary_Tumor-Breast_Carcinoma-Infiltrating_Lobular_Carcinoma|TCGA-Breast / Sample_Type by Project: Shred V9

ZBTB48 LMNTD2 HSPA12B RGS12 KLF2 MZF1

7.25e-061551336a4f2fffa8d0de760c556c3f8f1c91804eedbfa68
ToppCell3'_v3-lymph-node_spleen-Hematopoietic_progenitors-Progenitor|lymph-node_spleen / Manually curated celltypes from each tissue

TNFRSF18 GPRC5C FNBP1L GUCY1A1 PALLD BAHCC1

1.11e-051671336cb396f3edb9e8fdc316091e8e193dbba50e0be0c
ToppCell3'-Child09-12-SmallIntestine-Hematopoietic-T_cells-NK_T_cell|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ACAP1 AMZ1 PTPN22 TNFRSF18 CBLB P2RX7

1.15e-051681336b4b73f3fc9f4c3d87ca0a63ff8b2842141ccd0e6
ToppCell10x5'-GI_small-bowel-Lymphocytic_Invariant-Inducer-like-ILC3|GI_small-bowel / Manually curated celltypes from each tissue

PERM1 TNFRSF18 GPRC5C KLF2 MAST4 MMP9

1.23e-05170133697df5ffb328196c46568975d2d97722bcc753bf5
ToppCellfacs-Heart-RA-18m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DGKB BEND3 GRIN2D MEAK7 LIN9 SLC8A2

1.27e-051711336b54d9d6b03c9c6f28a71cf2ed2bfa9a335bba949
ToppCellfacs-Heart-RA-18m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DGKB BEND3 GRIN2D MEAK7 LIN9 SLC8A2

1.27e-0517113369d825a2e799421af4f2cf4f4dc8e239b5d00476d
ToppCellfacs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RPS6KA2 SREBF2 MAST4 SH3PXD2A ATP2A3 TBL2

1.40e-051741336f1fe1f4216748a9562dd03bd48c70b23c7ff4d1d
ToppCellfacs-Heart-RV-18m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DGKB GPRC5C KISS1R MYL9 CSPG4 PALLD

1.45e-051751336d8e385320f554d974538b7cdc4f8e4767f1455f2
ToppCellfacs-Heart-RV-18m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DGKB GPRC5C KISS1R MYL9 CSPG4 PALLD

1.45e-051751336cf15465855602ba135752c18755e3e058dbd42ec
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

LAMC3 CBLB MYL9 GFPT2 PALLD ADAMTSL2

1.50e-0517613369bc87cd5cda2372e1bce94c9dfd408eb1dfd8d0c
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

LAMC3 CBLB MYL9 GFPT2 PALLD ADAMTSL2

1.50e-0517613363f8274a7ab67f9f8a8923193763a5543cfe4defa
ToppCelldroplet-Heart-nan-3m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DGKB SLC8A2 MYL9 GUCY1A1 CSPG4 PALLD

1.54e-051771336dbdbdc8ed9ef0b529694242ef9f9f07a42e16005
ToppCelldroplet-Heart-nan-3m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DGKB SLC8A2 MYL9 GUCY1A1 CSPG4 PALLD

1.59e-051781336416f85e51f45ec7949451fd47611a84e33e87245
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

LAMC3 FNBP1L GRIN2D RGS12 SLC35F4 CNTNAP4

1.81e-0518213367dc61e901428cea04f00ebb0939a44d21a6145c6
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DGKB CSMD3 FREM2 SCN2A CNTNAP4 OTOG

1.92e-0518413362cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DGKB CSMD3 FREM2 SCN2A CNTNAP4 OTOG

1.92e-051841336ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Liver-Non-hepatocytes-3m-Lymphocytic-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACAP1 PTPN22 TNFRSF18 P2RX7 MMP9 ATP2A3

1.92e-0518413368fc047977fad38fcd26eebcc279a688efd342ed8
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DGKB CSMD3 FREM2 SCN2A CNTNAP4 OTOG

1.92e-0518413362b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellCOPD-Endothelial-VE_Capillary_A|COPD / Disease state, Lineage and Cell class

EXPH5 FNBP1L HSPA12B OPHN1 FZD4 PLEKHG1

1.92e-0518413365f4f7775d488ececf086c71441defecbee9d8a9c
ToppCelldroplet-Heart-4Chambers-21m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DGKB GPRC5C MYL9 GUCY1A1 CSPG4 PALLD

1.98e-05185133630df02fbe2828e3c4f3e5c4cda855e74fb31be39
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

LAMC3 FNBP1L GRIN2D RGS12 SLC35F4 CNTNAP4

1.98e-051851336cefd81adb480c027545a5c78dcd05669783717f4
ToppCellIPF-Lymphoid-T_Regulatory|World / Disease state, Lineage and Cell class

ACAP1 PTPN22 TNFRSF18 CBLB TBC1D4 MAST4

1.98e-05185133677fbecdab10bacc005b1c7e22ca414cfecef13c1
ToppCelldroplet-Kidney-KIDNEY-30m-Epithelial-kidney_mesangial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DGKB LAMC3 MYL9 GUCY1A1 CSPG4 DACT3

2.11e-051871336ddfc2d1d9fcc3d8e4d3d015576bb17eebf44ada9
ToppCellfacs-Heart-LA-3m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

INPP5B DGKB GPRC5C MYL9 GUCY1A1 CSPG4

2.11e-051871336a12f383b02b07af32cc53a154685df8dba8fbd3f
ToppCellfacs-Heart-LA-3m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

INPP5B DGKB GPRC5C MYL9 GUCY1A1 CSPG4

2.11e-051871336c40c152fa14e6afc9188549534b64ccbaded56b3
ToppCelldroplet-Heart-4Chambers-18m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABAT DGKB GPRC5C MYL9 GUCY1A1 CSPG4

2.11e-051871336dba4924d914a7dcd4901142684ba920c2404860b
ToppCelldroplet-Heart-4Chambers-18m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABAT DGKB GPRC5C MYL9 GUCY1A1 CSPG4

2.11e-0518713369688141beef4f62613d7a810c5872ccb9afc1a71
ToppCelldroplet-Heart-4Chambers-21m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DGKB GPRC5C MYL9 GUCY1A1 CSPG4 PALLD

2.11e-0518713368ff9f771d10c372d771c92dfa9006aa81aec4681
ToppCellSubstantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

CACNA1B SYNDIG1L GRIN2D CELSR3 SCN2A CNTNAP4

2.17e-051881336b73e8a40393c3f656e2fcfe395a761b1f985c254
ToppCell5'-Adult-SmallIntestine-Hematopoietic-T_cells-gdT|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ACAP1 PTPN22 TNFRSF18 CBLB KISS1R P2RX7

2.24e-0518913365c85656f555d91ecc9540faa67717694a4aef92f
ToppCell5'-Adult-Appendix-Mesenchymal-Pericytes|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

COL4A6 PERM1 MYL9 GUCY1A1 CSPG4 PALLD

2.24e-0518913360daa8efac08dca9525d2b8d421952068cab4eb50
ToppCell5'-Adult-Appendix-Mesenchymal-Pericytes-Contractile_pericyte_(PLN+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

COL4A6 PERM1 MYL9 GUCY1A1 CSPG4 PALLD

2.24e-051891336b6bb4327b4560d07d2b728abcc5f144f428948a5
ToppCelldroplet-Kidney-nan-21m-Epithelial-Stroma____kidney_mesangial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DGKB SLC8A2 MYL9 GUCY1A1 CSPG4 PALLD

2.30e-051901336e04f47705851563515b6a66a2634cf7a574f7bda
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

LAMC3 MYL9 GUCY1A1 CSPG4 DACT3 PALLD

2.30e-05190133670c86dd454afb21d4a85db56c5f369d4b342bc97
ToppCelldroplet-Limb_Muscle-Pre-Sort-18m-Mesenchymal-smooth_muscle_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DGKB SLC8A2 MYL9 GUCY1A1 CSPG4 PALLD

2.37e-0519113368e8beb8e8a3b33cac83d3f7ce915a71e3654fdab
ToppCellfacs-Lung-3m-Endothelial-capillary_endothelial-capillary_endothelial_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

AARD ITGA6 HSPA12B RGS12 KLF2 ATP2A3

2.37e-05191133638fe60a8570f3c6eb8e8f8646f90d505dfd7d647
ToppCelldroplet-Kidney-KIDNEY-1m-Epithelial-Stroma____kidney_mesangial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DGKB SLC8A2 MYL9 GUCY1A1 CSPG4 DACT3

2.37e-0519113368597a8af294f24496c317d995f07eb5dcc25c13c
ToppCellfacs-Lung-3m-Endothelial-capillary_endothelial|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

AARD ITGA6 HSPA12B RGS12 KLF2 ATP2A3

2.37e-0519113360e6cd2628a5cebd35e960e4eb3b52ddc9358031c
ToppCelldroplet-Limb_Muscle-Pre-Sort-18m-Mesenchymal-unknown|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DGKB PERM1 MYL9 GUCY1A1 CSPG4 PALLD

2.37e-05191133660bc1f3efa7bbad5cb7944fe5e049ea79cd1745a
ToppCellBAL-Severe-Lymphocyte-T/NK-CD4+_T-Treg-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

FBLN7 ACAP1 PTPN22 TNFRSF18 TBC1D4 MAST4

2.44e-051921336d85a785a12076e34c404171363a647f318926b18
ToppCelldroplet-Lung-18m-Mesenchymal-myofibroblast|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

COL4A6 DGKB MYL9 GUCY1A1 CSPG4 PALLD

2.44e-0519213362cc712186e37fb21a964c032765c36a8b4a852cf
ToppCellfacs-Brain_Non-Myeloid-Cortex_-18m-Mesenchymal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DGKB GPRC5C MYL9 GUCY1A1 CSPG4 PALLD

2.44e-05192133620fd69eb60b93d22d9be39de44b733db6d761dde
ToppCelldroplet-Kidney-nan-3m-Epithelial-kidney_mesangial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DGKB MYL9 GUCY1A1 CSPG4 DACT3 PALLD

2.44e-0519213363617d2bc7e33d981f3ec349e9962d8d4bd822fbd
ToppCellBAL-Severe-Lymphocyte-T/NK-CD4+_T-Treg|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

FBLN7 ACAP1 PTPN22 TNFRSF18 TBC1D4 MAST4

2.44e-051921336230f3090607a62bb6d1e1f4b0341ee96d93f1c00
ToppCell5'-Adult-Distal_Rectal-Mesenchymal-Pericytes|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PERM1 MYL9 GUCY1A1 CSPG4 DACT3 PALLD

2.52e-0519313367631bf3362b4fa061ffeab4879ab12c4708dc4c0
ToppCellEpithelial-club_cell|World / Lineage, Cell type, age group and donor

SREBF2 FNBP1L PLEKHG1 MAST4 NECTIN4 FHIP1A

2.52e-0519313362bdd09004fa433550958ec42ba4b06271a4aaf7c
ToppCell5'-Adult-Distal_Rectal-Mesenchymal-Pericytes-Contractile_pericyte_(PLN+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PERM1 MYL9 GUCY1A1 CSPG4 DACT3 PALLD

2.52e-0519313368d15c63f2ae48d0a00d7ef5fdafa917ab8ad0571
ToppCellE16.5-samps-Epithelial-Alveolar_epithelial_precursor|E16.5-samps / Age Group, Lineage, Cell class and subclass

COL4A6 EXPH5 TST FREM2 TMEM171 LSR

2.52e-051931336c1817ad675b9f9d2d3436c8b9646edf89f0d4c82
ToppCellE16.5-samps-Epithelial|E16.5-samps / Age Group, Lineage, Cell class and subclass

COL4A6 EXPH5 TST FREM2 TMEM171 LSR

2.52e-0519313361cb5a1cffa2b4a3bfecca16b791c1992edeb237d
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

AHI1-DT CASR FNBP1L FREM2 MAST4 FHIP1A

2.59e-0519413365eaaa81f4b2535f983c424aaef00077089526a5c
ToppCell11.5-Distal-Mesenchymal-Pericyte|Distal / Age, Tissue, Lineage and Cell class

GPR37 ARHGAP26 GATM LAMC3 MYL9 CSPG4

2.59e-05194133608701590496cf85ff790e54a81493c61177e76ff
ToppCellPCW_05-06-Mesenchymal-Mesenchymal_cycling-mes_proliferating1_(3)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

FBLN7 POLE LAMC3 XRCC3 ASF1B CDC25A

2.67e-05195133656d8734d020b3da08a5aa9e67999706a9e023a99
ToppCell10x_3'_v2v3-Non-neoplastic-Vascular|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

LAMC3 GPRC5C MYL9 GUCY1A1 CSPG4 MMP9

2.74e-05196133640e6900a0d56088a40d37ec312f53207ea952602
ToppCell10x_3'_v2v3-Non-neoplastic-Vascular-Mural_cell-SMC_prolif|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

LAMC3 GPRC5C MYL9 GUCY1A1 CSPG4 MMP9

2.74e-0519613369a420a4eb46cb554bec641726fea5398ff60f630
ToppCell5'-Adult-SmallIntestine-Mesenchymal-Pericytes-Contractile_pericyte_(PLN+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PERM1 MYL9 GUCY1A1 CSPG4 DACT3 PALLD

2.74e-051961336ce6f7ddb8104471dc90347f427486379914d63b4
ToppCell3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-tracheobronchial_smooth_muscle_cell-SM_activated_stress_response-SM_activated_stress_response_L.2.3.0.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MYL9 IER5L GUCY1A1 CSPG4 DACT3 PALLD

2.74e-051961336ac4c8571bd792538f8df7b9bdd90ef58405fd3b1
DrugNaftifine hydrochloride [65473-14-5]; Down 200; 12.4uM; MCF7; HT_HG-U133A

INPP5B PTPN22 ACAD10 XRCC3 RGS12 KLF2 WIZ CELSR3 TMEM259 ATP2A3

2.23e-07196132103536_DN
DrugPipenzolate bromide [125-51-9]; Down 200; 9.2uM; MCF7; HT_HG-U133A

INPP5B RPS6KA2 RGS12 MAPK8IP3 KLF2 NF1 WIZ SEMA3B

1.87e-0519513286821_DN
DrugIsradipine [75695-93-1]; Down 200; 10.8uM; MCF7; HT_HG-U133A

INPP5B XRCC3 MAPK8IP3 KLF2 MAST4 WIZ MZF1 ATP2A3

1.87e-0519513285447_DN
DrugTadjakonine [11087-94-8]; Down 200; 7.4uM; MCF7; HT_HG-U133A

KDM5A INPP5B ACAD10 TBC1D4 WIZ CDC25A MAP2K3 ATP2A3

1.87e-0519513282820_DN
DrugDinoprost trometamol [38362-01-5]; Down 200; 8.4uM; MCF7; HT_HG-U133A

ACAP1 RPS6KA2 SREBF2 NF1 CELSR3 TMEM259 GFPT2 BAHCC1

1.94e-0519613285409_DN
DrugBAPTA

CACNA1B GRIN2D EPX KISS1R MYL9 P2RX7 CHRNA10 MAP2K3 MYL12B ATP2A3

2.00e-0532413210CID000104751
DrugFolinic acid calcium salt [6035-45-6]; Up 200; 7.8uM; MCF7; HT_HG-U133A

ZBTB48 KDM5A RGS12 WIZ MZF1 TMEM259 CDC25A ATP2A3

2.01e-0519713283442_UP
DrugNitrarine dihydrochloride [20069-05-0]; Down 200; 10.6uM; MCF7; HT_HG-U133A

KDM5A ITGA6 MAPK8IP3 TBC1D4 TMEM259 SEMA3B CDC25A MAP2K3

2.08e-0519813284705_DN
DrugMerbromin [129-16-8]; Down 200; 5uM; PC3; HT_HG-U133A

COL4A6 ARHGAP26 NF1 MAST4 MZF1 CHRNA10 TBL2 ARHGAP33

2.08e-0519813283700_DN
DrugCephalothin sodium salt [58-71-9]; Up 200; 9.6uM; MCF7; HT_HG-U133A

COL4A6 ACAP1 KDM5A MLNR INPP5B ARHGAP26 RGS12 MAPK8IP3

2.08e-0519813286819_UP
Drugrosiglitazone; Down 200; 10uM; HL60; HT_HG-U133A

ARHGAP26 GATM GPRC5C MAPK8IP3 FZD4 MZF1 SH3PXD2A MMP9

2.16e-0519913282693_DN
Drug4-hydroxybenzyl alcohol

ABAT MYL9 SCN2A

3.04e-05111323CID000000125
Druggastrodin

CACNA1B ABAT SCN2A

3.04e-05111323CID000115067
DrugVigabatrin

ABAT GABBR1

3.34e-0521322DB01080
Drug2-aminothiophenol

C4A C4B

9.97e-0531322ctd:C005464
Drugconotoxin alpha-RgIA, Conus regius

CHRNA10 GABBR1

9.97e-0531322ctd:C510079
Drugeosinic acid

EPX C4A

9.97e-0531322CID000011689
DrugAC1L97VK

GATM EPX LPO

1.01e-04161323CID000439703
DrugLY294002; Up 200; 10uM; MCF7; HG-U133A

GPRC5C CBLB LSR TBC1D4 WIZ MZF1 MYL12B

1.24e-041901327328_UP
DrugHomochlorcyclizine dihydrochloride [1982-36-1]; Up 200; 10.4uM; MCF7; HT_HG-U133A

KDM5A EXPH5 INPP5B RGS12 NF1 MAST4 MZF1

1.28e-0419113277417_UP
Drugcis-4,7,10,13,16,19-Docosahexaenoic acid ethyl ester; Up 200; 100uM; MCF7; HT_HG-U133A_EA

NOP56 INPP5B XRCC3 MAPK8IP3 NF1 WIZ CDC25A

1.36e-041931327881_UP
DrugEtilefrine hydrochloride [534-87-2]; Down 200; 18.4uM; HL60; HT_HG-U133A

ACAP1 ABAT NOP56 ZBTB48 DHX57 MZF1 ZSCAN16

1.36e-0419313272930_DN
DrugMeclocycline sulfosalicylate [73816-42-9]; Up 200; 5.8uM; HL60; HT_HG-U133A

ABAT ACAD10 KLF2 NF1 TMEM259 ZSCAN16 BAHCC1

1.36e-0419313271341_UP
DrugPrilocaine hydrochloride [1786-81-8]; Down 200; 15.6uM; MCF7; HT_HG-U133A

ZBTB48 KDM5A WIZ TMEM259 CDC25A ATP2A3 BAHCC1

1.36e-0419313273624_DN
DrugDimenhydrinate [523-87-5]; Down 200; 8.6uM; MCF7; HT_HG-U133A

PTPN22 XRCC3 MAPK8IP3 KLF2 NF1 SEMA3B ARHGAP33

1.41e-0419413275450_DN
Drugyohimbine; Up 200; 22.9uM; MCF7; HT_HG-U133A_EA

ZNF672 GPRC5C NF1 CELSR3 MZF1 ZSCAN16 MAP2K3

1.41e-0419413271119_UP
DrugGlibenclamide [10238-21-8]; Down 200; 8uM; MCF7; HT_HG-U133A

ZBTB48 INPP5B RPS6KA2 NF1 MAST4 TMEM259 GFPT2

1.45e-0419513273163_DN
DrugPancuronium bromide [15500-66-0]; Down 200; 5.4uM; MCF7; HT_HG-U133A

KDM5A INPP5B RGS12 NF1 MZF1 CDC25A ARHGAP33

1.45e-0419513274393_DN
DrugOzagrel hydrochloride [78712-43-3]; Up 200; 15.2uM; HL60; HT_HG-U133A

ACAP1 SREBF2 GATM TBC1D4 CDC25A ATP2A3 BAHCC1

1.45e-0419513272942_UP
DrugMetampicillin sodium salt [6489-61-8]; Up 200; 10.4uM; PC3; HT_HG-U133A

KDM5A RPS6KA2 ARHGAP26 RGS12 MAPK8IP3 MYL9 ATP2A3

1.45e-0419513275115_UP
Drugretinoic acid; Down 200; 1uM; MCF7; HT_HG-U133A

GPR37 ITGA6 GPRC5C MEAK7 NF1 TULP4 MMP9

1.45e-0419513276971_DN
DrugApomorphine hydrochloride hemihydrate [41372-20-7]; Up 200; 6.4uM; MCF7; HT_HG-U133A

GPRC5C TBC1D4 NF1 MAST4 WIZ GFPT2 ARHGAP33

1.45e-0419513275283_UP
DrugMethoxamine hydrochloride [61-16-5]; Down 200; 16.2uM; PC3; HT_HG-U133A

NOP56 ACAD10 NF1 TMEM259 SEMA3B ARHGAP19 BAHCC1

1.50e-0419613276627_DN
DrugMethylatropine nitrate [52-88-0]; Up 200; 11uM; HL60; HT_HG-U133A

LAMC3 MEAK7 PPP1R26 CELSR3 CSPG4 CHRNA10 ATP2A3

1.50e-0419613273116_UP
DrugN-Acetyl-L-leucine [1188-21-2]; Down 200; 23uM; MCF7; HT_HG-U133A

EXPH5 RPS6KA2 SREBF2 ITGA6 NF1 SEMA3B CDC25A

1.50e-0419613276462_DN
DrugCyproterone acetate [427-51-0]; Up 200; 9.6uM; MCF7; HT_HG-U133A

AMN MLNR RGS12 NF1 WIZ SEMA3B CHRNA10

1.50e-0419613273545_UP
DrugAminohippuric acid [61-78-9]; Down 200; 20.6uM; MCF7; HT_HG-U133A

SREBF2 ITGA6 TSSC4 RGS12 KLF2 NF1 GFPT2

1.50e-0419613275394_DN
DrugXamoterol hemifumarate [73210-73-8]; Up 200; 5uM; HL60; HT_HG-U133A

ARHGAP26 LAMC3 MEAK7 RGS12 GUCY1A1 CSPG4 PALLD

1.50e-0419613273064_UP
DrugAdamantamine fumarate [80789-67-9]; Up 200; 9.6uM; HL60; HT_HG-U133A

ACAP1 ZBTB48 XRCC3 WIZ MZF1 ARHGAP33 BAHCC1

1.50e-0419613271344_UP
DrugS(+)-Terguride [37686-84-3]; Down 200; 11.8uM; MCF7; HT_HG-U133A

ITGA6 PTPN22 XRCC3 RGS12 NF1 MZF1 SEMA3B

1.55e-0419713275400_DN
DrugQuinic acid [86-68-0]; Up 200; 19.6uM; MCF7; HT_HG-U133A

ACAP1 GATM RGS12 MAST4 CHRNA10 ATP2A3 ZNF646

1.55e-0419713273540_UP
DrugVincamine [1617-90-9]; Up 200; 11.2uM; MCF7; HT_HG-U133A

COL4A6 PTPN22 KLF2 NF1 TMEM259 CDC25A ZNF646

1.55e-0419713272327_UP
DrugPromethazine hydrochloride [58-33-3]; Up 200; 12.4uM; MCF7; HT_HG-U133A

SREBF2 LAMC3 CBLB MZF1 CDC25A ATP2A3 BAHCC1

1.55e-0419713275317_UP
DrugTranylcypromine hydrochloride [1986-47-6]; Up 200; 23.6uM; PC3; HT_HG-U133A

INPP5B XRCC3 MAPK8IP3 NF1 CELSR3 ZSCAN16 TBL2

1.59e-0419813277293_UP
DrugChlorthalidone [77-36-1]; Down 200; 11.8uM; MCF7; HT_HG-U133A

ZBTB48 RPS6KA2 RGS12 KLF2 MAST4 MZF1 MAP2K3

1.59e-0419813273198_DN
DrugCefaclor [70356-03-5]; Down 200; 10.4uM; MCF7; HT_HG-U133A

EXPH5 GPRC5C RGS12 TBC1D4 MZF1 TMEM259 GFPT2

1.59e-0419813274967_DN
DrugConvolamine hydrochloride [500-56-1]; Up 200; 11.8uM; PC3; HT_HG-U133A

GPR37 ARHGAP26 KLF2 WIZ TMEM259 MMP9 ARHGAP33

1.59e-0419813275876_UP
DrugHomosalate [118-56-9]; Up 200; 15.2uM; MCF7; HT_HG-U133A

COL4A6 ACAP1 RPS6KA2 PTPN22 EPX MAPK8IP3 NF1

1.59e-0419813273879_UP
DrugTrimipramine maleate salt [521-78-8]; Up 200; 9.8uM; MCF7; HT_HG-U133A

GPR37 ARHGAP26 RGS12 NF1 WIZ SEMA3B ZNF646

1.59e-0419813273342_UP
DrugMexiletine hydrochloride [5370-01-4]; Down 200; 18.6uM; HL60; HT_HG-U133A

ACAP1 DHX57 NF1 MZF1 ZSCAN16 CDC25A ATP2A3

1.59e-0419813272364_DN
Drugwortmannin from Penicillium funiculosum; Down 200; 0.01uM; HL60; HT_HG-U133A

POLE DHX57 TSSC4 TBC1D4 WIZ TULP4 MZF1

1.59e-0419813271184_DN
DrugDehydrocholic acid [81-23-2]; Up 200; 9.6uM; MCF7; HT_HG-U133A

INPP5B EPX MAPK8IP3 SLC8A2 NF1 WIZ ATP2A3

1.59e-0419813271523_UP
DrugFenspiride hydrochloride [5053-08-7]; Down 200; 13.4uM; MCF7; HT_HG-U133A

ZBTB48 KDM5A MAPK8IP3 KLF2 NF1 CDC25A ARHGAP33

1.59e-0419813276001_DN
DrugNimesulide [51803-78-2]; Up 200; 13uM; MCF7; HT_HG-U133A

DHX57 NF1 WIZ TMEM259 SEMA3B ATP2A3 ARHGAP33

1.59e-0419813277024_UP
DrugConvolamine hydrochloride [500-56-1]; Down 200; 11.8uM; HL60; HG-U133A

RPS6KA2 GPRC5C NF1 MZF1 ASF1B CDC25A ATP2A3

1.64e-0419913271779_DN
DrugGabapentin [60142-96-3]; Down 200; 23.4uM; MCF7; HT_HG-U133A

ZBTB48 GPR37 INPP5B ACAD10 MAPK8IP3 CDC25A MAP2K3

1.70e-0420013277229_DN
DrugPalmatine chloride [3486-67-7]; Down 200; 10.4uM; PC3; HT_HG-U133A

RPS6KA2 LAMC3 ACAD10 XRCC3 NF1 MAST4 BAHCC1

1.70e-0420013276612_DN
DrugAC1L380G

CASR LSR ATP2A3

1.72e-04191323CID000084698
DiseaseThyroid preparation use measurement

AHI1-DT INPP5B PTPN22 CHD7 EPX CBLB TMEM171

4.47e-052171277EFO_0009933
Diseasekidney disease (biomarker_via_orthology)

SREBF2 GATM MMP9

9.79e-05211273DOID:557 (biomarker_via_orthology)
DiseaseJUVENILE MYELOMONOCYTIC LEUKEMIA

ARHGAP26 NF1

1.10e-0441272607785
DiseaseAbnormality of the nervous system

ZSCAN16 PALLD

1.10e-0441272HP_0000707
DiseaseX-linked mental retardation with cerebellar hypoplasia and distinctive facial appearance (implicated_via_orthology)

ARHGAP26 OPHN1

1.10e-0441272DOID:0080311 (implicated_via_orthology)
DiseaseMalignant Peripheral Nerve Sheath Tumor

NF1 SH3PXD2A

1.10e-0441272C0751690
DiseaseJuvenile myelomonocytic leukemia

ARHGAP26 NF1

1.10e-0441272cv:C0349639
Diseaseautoimmune thyroid disease

ACAP1 AHI1-DT INPP5B PTPN22 CBLB

2.20e-041261275EFO_0006812
Diseaseeosinophil count

ARHGAP26 ITGA6 BEND3 CASR CHD7 ACAD10 EPX CBLB KLF2 TBC1D4 LPO HELZ2 YDJC ATP2A3 GABBR1 ARHGAP19 BAHCC1

2.23e-04148812717EFO_0004842
Diseaselactoperoxidase measurement

EPX LPO

2.73e-0461272EFO_0020525
Diseasediastolic blood pressure, unipolar depression

ACAD10 PLEKHG1 GUCY1A1

2.90e-04301273EFO_0003761, EFO_0006336
DiseaseLead Poisoning

XRCC3 MMP9

3.81e-0471272C0023176
Diseasejuvenile myelomonocytic leukemia (is_implicated_in)

ARHGAP26 NF1

3.81e-0471272DOID:0050458 (is_implicated_in)
DiseaseVasogenic Brain Edema

MYL9 MMP9

5.06e-0481272C0750969
DiseaseCytotoxic Brain Edema

MYL9 MMP9

5.06e-0481272C0750970
DiseaseCytotoxic Cerebral Edema

MYL9 MMP9

5.06e-0481272C0472388
DiseaseVasogenic Cerebral Edema

MYL9 MMP9

5.06e-0481272C0472387
DiseaseBrain Edema

MYL9 MMP9

5.06e-0481272C1527311
DiseaseCerebral Edema

MYL9 MMP9

5.06e-0481272C0006114
Diseaseautism spectrum disorder (implicated_via_orthology)

KDM5A LAMC3 CHD7 SCN2A CNTNAP4

5.21e-041521275DOID:0060041 (implicated_via_orthology)
Diseaseorofacial cleft, sex interaction measurement

ZNF672 EXPH5 TMEM171 NF1

5.29e-04861274EFO_0008343, MONDO_0000358
Diseaseatherosclerosis (is_marker_for)

CASR WIZ NONO

5.44e-04371273DOID:1936 (is_marker_for)
DiseaseGraves' disease (is_implicated_in)

PTPN22 C4A C4B

6.35e-04391273DOID:12361 (is_implicated_in)
Diseaseinfluenza A severity measurement

SLC35F4 GUCY1A1

6.49e-0491272EFO_0007743
Diseasehuman papilloma virus infection, oral cavity cancer

LAMC3 TBC1D4 ATP2A3

7.91e-04421273EFO_0001668, EFO_0005570
Diseasemyocardial infarction

INPP5B ARHGAP26 DGKB ACAD10 PLEKHG1 GUCY1A1 MMP9

8.24e-043501277EFO_0000612
DiseaseColorectal Carcinoma

COL4A6 ACAP1 VPS18 POLE CSMD3 KLF2 FZD4 NF1 P2RX7 ZSCAN16

9.40e-0470212710C0009402
DiseaseFVC change measurement, response to placebo

AMZ1 DGKB

1.39e-03131272EFO_0008344, EFO_0010339
Diseasealkaline phosphatase measurement

ACAP1 PAPLN PTPN22 GPRC5C ACAD10 FNBP1L NF1 P2RX7 MMP9 TBL2 GABBR1 ADAMTSL2

1.48e-03101512712EFO_0004533
Diseasediastolic blood pressure, alcohol consumption measurement

ACAD10 PLEKHG1 GUCY1A1

1.65e-03541273EFO_0006336, EFO_0007878
DiseaseRASopathy

ARHGAP26 NF1

1.86e-03151272cv:C5555857
Diseasesyndromic intellectual disability (implicated_via_orthology)

KDM5A OPHN1

2.12e-03161272DOID:0050888 (implicated_via_orthology)
Diseasetemporal arteritis (is_implicated_in)

PTPN22 MMP9

2.12e-03161272DOID:13375 (is_implicated_in)
DiseaseMalignant neoplasm of skin

POLE XRCC3 MMP9

2.12e-03591273C0007114
DiseaseSkin Neoplasms

POLE XRCC3 MMP9

2.12e-03591273C0037286
Diseaseneuroimaging measurement

AMZ1 BEND3 CHD7 MEAK7 MAPK8IP3 PLEKHG1 NF1 MAST4 SH3PXD2A TBL2 GABBR1 BAHCC1

2.27e-03106912712EFO_0004346
Diseaseresponse to opioid

ABAT IRX6 ADAMTSL2

2.34e-03611273EFO_0008541
Diseasesystemic lupus erythematosus (is_implicated_in)

PTPN22 C4A C4B

2.45e-03621273DOID:9074 (is_implicated_in)
Diseasefish consumption measurement

DGKB ACAD10 NF1

2.68e-03641273EFO_0010139
DiseaseSjogren's syndrome (is_implicated_in)

PTPN22 MMP9

2.69e-03181272DOID:12894 (is_implicated_in)
DiseaseJuvenile Myelomonocytic Leukemia

ARHGAP26 NF1

3.00e-03191272C0349639
Diseaselifestyle measurement

RGS12 FHIP1A CRB2 BAHCC1 ZNF646

3.55e-032351275EFO_0010724
DiseaseLupus Erythematosus, Systemic

PTPN22 C4A C4B

3.60e-03711273C0024141
Diseasevitiligo (is_implicated_in)

PTPN22 C4A

3.66e-03211272DOID:12306 (is_implicated_in)
Diseasecarotid artery disease (is_implicated_in)

SREBF2 MMP9

4.01e-03221272DOID:3407 (is_implicated_in)
Diseaselymphocyte count

ACAP1 AMN EXPH5 AMZ1 BEND3 PTPN22 CHD7 ACAD10 EPX MEAK7 KLF2 TMEM171 LSR GUCY1A1

4.25e-03146412714EFO_0004587

Protein segments in the cluster

PeptideGeneStartEntry
DVFCRDGEEFLFRTG

TBC1D12

686

O60347
RSSCRVDVAAFPFDA

CHRNA10

151

Q9GZZ6
RPACDFFGDGRSTDI

AARD

31

Q4LEZ3
LFNPSRAFACREEGS

BAHCC1

1776

Q9P281
EDFRATPFIECSGAR

COL4A6

1626

Q14031
EVGVCSFARFSGEFP

AMZ1

201

Q400G9
EGDGFSNRDVLRFEC

CSMD3

676

Q7Z407
EPATEFSCRELEAGS

CSPG4

611

Q6UVK1
FDSVPTSRECVGFEA

C4B

1526

P0C0L5
LPDGETCSDASREFR

BCDIN3D

91

Q7Z5W3
SGFSREVPFSNCSRD

CASR

531

P41180
ARAFGEEEFLSSCPR

GPR32

336

O75388
RERPIGFFCDCTFSA

CNTNAP4

976

Q9C0A0
ITAEGFLREFGRLCS

ACAD10

96

Q6JQN1
PDSERRFCFEVVSTS

ACAP1

321

Q15027
CGAGEPAVFRDSDRF

AMN

96

Q9BXJ7
RPRASTAFFQEEGPC

AHI1-DT

141

P0C7V0
DRFADLCAVGSPFAR

CACNA1B

436

Q00975
DSDRFVFLLCTRAGG

CHD7

1356

Q9P2D1
PLFAGIDCEVFESRF

ATP2A3

881

Q93084
DFRSPQEEDFRCPSD

RBM12B

826

Q8IXT5
RRECGLAAPRFSFND

IRX6

306

P78412
KRFCFDIETNERPGT

OPHN1

331

O60890
LEFGPFSVSCEAEKR

PTPN22

151

Q9Y2R2
PELFSDVDFSRGCSA

BEND3

276

Q5T5X7
GDSAFSRAPRCAQVE

FBLN7

186

Q53RD9
DRDKLFGFCPTRADS

MMP9

321

P14780
RIDCFSEVPTSVFGE

NOP56

381

O00567
DRCSEGSFLLTTFPR

NONO

206

Q15233
GKPRRCSSAFFEEER

LIN9

171

Q5TKA1
LEFFPDDDCTSSARR

MAPK8IP3

626

Q9UPT6
TTEFEPCFDAADFIR

GATM

246

P50440
PCFDAADFIRAGRDI

GATM

251

P50440
ERPFVARFGFDVVTC

FN3KRP

136

Q9HA64
RSIFAVSPDGFVCDD

LRIG3

481

Q6UXM1
EVPDGFVCVAEATFR

CRB2

861

Q5IJ48
ALDGARVDFRCDPDF

GABBR1

121

Q9UBS5
VEPVEDRFVFRCSDG

FREM2

1156

Q5SZK8
RGTFCSFDTPDDSIR

ABAT

436

P80404
FDPRDEGSRCCSIID

CBLB

426

Q13191
GTDPEDVIRNAFACF

MYL9

96

P24844
SPARVAFTAGVDCER

EPX

241

P11678
ARVPCFLAGDSRASE

LPO

361

P22079
FPPLFVEAFTSRRCE

PRAMEF18

36

Q5VWM3
EICRASEFPAFRGLR

DNAH12

2396

Q6ZR08
CSEAFPSRALERAFA

KISS1R

191

Q969F8
ELFPDISRGCEAFLR

KDM4E

226

B2RXH2
PPDGRSFREEQCVSF

ADAMTSL2

106

Q86TH1
SRRFRSFSELPSCDG

EXPH5

1846

Q8NEV8
FSFGDPCGDRFERDT

TUBGCP6

196

Q96RT7
PCGDRFERDTRVSLF

TUBGCP6

201

Q96RT7
TAESRFGFRFLSCLP

LMNTD2

611

Q8IXW0
SRLGPCSFAELVFRD

NLRP2

251

Q9NX02
ALESGVFRSDIPCRF

POLE

546

Q07864
GEFSEEAQFRDPCRS

POLE

2136

Q07864
CDITARGPCTRIEFD

ITGA6

86

P23229
SRVGRSFCSQFLPEE

MEAK7

6

Q6P9B6
CAAEDARFITDPGVR

HSPA12B

611

Q96MM6
VAEECSKPREAFGFE

KDM5A

341

P29375
SPNLRCFTFDRGDIS

NSUN4

126

Q96CB9
CFTFDRGDISRFPPA

NSUN4

131

Q96CB9
PDFSTCASRRFLFGV

GPRC5C

111

Q9NQ84
TFPEDAGIFTCSARN

PALLD

511

Q8WX93
CPIFRLGDIFRETGD

P2RX7

226

Q99572
GFFPSECVELFTERP

ARHGAP33

236

O14559
GRERISCDFEEAAEP

FZD4

276

Q9ULV1
PFRFEISFECSEALA

ASF1B

21

Q9NVP2
RFALRAAGFVPDDCA

DNAH6

376

Q9C0G6
ERPFPEAFSESACIV

FHIP1A

476

Q05DH4
EDLGFSGRAPAERCI

GPR37

406

O15354
EACSSAERRARAGPF

DACT3

201

Q96B18
DEEPRFTSCVAFFNI

FNBP1L

61

Q5T0N5
LDRNTPVFRDDVCFF

GFPT2

406

O94808
PVFRDDVCFFISQSG

GFPT2

411

O94808
GDDFCIFSESRRPSR

DHX57

61

Q6P158
NFFRDVPDFRVLACG

DGKB

481

Q9Y6T7
PTRDQCFGDRFSRLL

TMEM259

241

Q4ZIN3
CSSSFPETRAGVREA

MAST4

2461

O15021
GEFRDCISSREFLQP

CEP192

2061

Q8TEP8
ARACPGFDSATRDPE

INPP5B

126

P32019
GAFEGPRCEVAARSF

CELSR3

1506

Q9NYQ7
DCRAFLTFTVDPQGA

HELZ2

1336

Q9BYK8
LGFVVDVEAGSRCFR

HELZ2

1741

Q9BYK8
DVEAGSRCFRLLFPS

HELZ2

1746

Q9BYK8
CEFFFPDVGAQRSRR

PERM1

616

Q5SV97
RARFEDFCPDSSPDA

IER5L

336

Q5T953
FDSVPTSRECVGFEA

C4A

1526

P0C0L4
FCRDRIADAFSPASV

LSR

131

Q86X29
IVVFHCEFSSERGPR

CDC25A

426

P30304
GPETAEAAALFSREC

MLNR

221

O43193
RCSIFPDLSFVTFDG

OTOG

2111

Q6ZRI0
ADRFSPEFVDFTAQC

MAP2K3

291

P46734
GTDPEDVIRNAFACF

MYL12B

96

O14950
ARACAEREPDPFEFS

TAF3

396

Q5VWG9
EPRAGSCETSFTEDR

SYNDIG1L

81

A6NDD5
ERFDVSICILGSPRF

RFPL1

161

O75677
GSEEEEIPFRCFICR

RNF113B

246

Q8IZP6
EKRFCFDVEAVDRPG

ARHGAP26

331

Q9UNA1
RFPRCFSEADEGVES

PPP1R26

26

Q5T8A7
AEPVRDIRCEFCGEF

WIZ

1221

O95785
FRECSRIFGEDGLTL

SLC35F4

231

A4IF30
TGERPFSCEFCEQRF

ZBTB48

516

P10074
FDSSGNVEEVCRPRT

TULP4

891

Q9NRJ4
ERPFECSECGRDFSQ

ZNF132

456

P52740
FSAVCPDDRRFFGLV

RGS12

301

O14924
ARRFGFECTADPDTN

RGS12

356

O14924
TESCPDGARDFRAEQ

PAPLN

76

O95428
FGVEGSSAFLECEPR

SEMA3B

581

Q13214
ISQCDEVFRFFEARP

SH3PXD2A

111

Q5TCZ1
CSLEAERGPDGRSFV

VPS18

206

Q9P253
FACPECGRRFSDRSD

ZNF672

311

Q499Z4
VFQCRRATPATEAGF

SREBF2

641

Q12772
GTISDPRAADFLFSC

TERB2

26

Q8NHR7
ARGFCLEDFTFLRDP

SCN2A

176

Q99250
IFDCLEGAARRAPSS

TSSC4

96

Q9Y5U2
GFRLRADRVSCEAFP

VWCE

251

Q96DN2
EASSERPFSCEVCGR

ZNF646

1196

O15015
PARAFACAVERDARA

YDJC

176

A8MPS7
ACAVERDARAAVGPF

YDJC

181

A8MPS7
RRFFLDIASDCPTSD

NF1

1476

P21359
ETRGRCEDSAAARPF

NRDC

31

O43847
ERFDVSVCILGSPRF

RFPL3

161

O75679
VPARESGRSDAICSF

ARHGAP19

11

Q14CB8
DPDRAFICGESRQFA

TMEM171

96

Q8WVE6
SSRVCFPERILEDSG

TBC1D4

291

O60343
RSCQFPEEERGERSA

TNFRSF18

216

Q9Y5U5
FPCEVCGRRFAADVL

ZC2HC1B

16

Q5TFG8
ECDECGRPFRVSSAL

ZSCAN16

321

Q9H4T2
CRRAGISAPVVFFVD

TP53RK

91

Q96S44
RQRDFLPFVCDDCSG

ZFAND1

16

Q8TCF1
RAGRASRANCPFEED

PLEKHG1

906

Q9ULL1
RHVPGASFFDIEECR

TST

51

Q16762
FDITGRFLASCGDRA

TBL2

381

Q9Y4P3
VIDSVAAPFRCEFDS

XRCC3

211

O43542
FLGSPCVDRLEDFTG

GUCY1A1

381

Q02108
FSTFASPCRERGLQE

KLF2

11

Q9Y5W3
PGEDERVAFCTSEFS

LAMC3

181

Q9Y6N6
RDESGSPESIRVCDF

RPS6KA2

541

Q15349
DGSREERLPSCFDYV

SLC8A2

711

Q9UPR5
ERPFVCSECGRSFSR

MZF1

381

P28698
LFCAREEAEPVFRAA

GRIN2D

246

O15399
ECRVSTFPAGSFQAR

NECTIN4

126

Q96NY8