Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionminus-end-directed microtubule motor activity

DNAH12 DNAH8 DNAH9 DNAH1

8.52e-0718844GO:0008569
GeneOntologyMolecularFunctiondynein light intermediate chain binding

DNAH12 DNAH8 DNAH9 DNAH1

5.52e-0628844GO:0051959
GeneOntologyMolecularFunctiondynein intermediate chain binding

DNAH12 DNAH8 DNAH9 DNAH1

1.73e-0537844GO:0045505
GeneOntologyMolecularFunctionhigh voltage-gated calcium channel activity

CACNA1C CACNA1D CACNA1F

2.53e-0514843GO:0008331
GeneOntologyMolecularFunctionDNA-dependent protein kinase activity

PRKDC ATM

5.23e-053842GO:0004677
GeneOntologyMolecularFunctionhistone H2AXS139 kinase activity

PRKDC ATM

5.23e-053842GO:0035979
GeneOntologyMolecularFunctiontRNA (cytidine-3-)-methyltransferase activity

METTL2A METTL2B

1.04e-044842GO:0052735
GeneOntologyMolecularFunctioninositol hexakisphosphate binding

SNAP91 GLE1

1.04e-044842GO:0000822
GeneOntologyMolecularFunctionHMG box domain binding

POU3F2 POU5F1 POU5F1B

1.20e-0423843GO:0071837
GeneOntologyMolecularFunctionhistone H2AX kinase activity

PRKDC ATM

1.73e-045842GO:0141003
GeneOntologyMolecularFunctionvoltage-gated calcium channel activity involved in cardiac muscle cell action potential

CACNA1C CACNA1D

1.73e-045842GO:0086007
GeneOntologyMolecularFunctionmicrotubule motor activity

DNAH12 DNAH8 DNAH9 DNAH1

2.16e-0470844GO:0003777
GeneOntologyMolecularFunctionPOU domain binding

POU5F1 POU5F1B

3.62e-047842GO:0070974
GeneOntologyMolecularFunctiontranslation initiation factor binding

CACNA1C TRIM32 GLE1

5.88e-0439843GO:0031369
GeneOntologyMolecularFunctiontRNA (cytidine) methyltransferase activity

METTL2A METTL2B

7.70e-0410842GO:0016427
GeneOntologyMolecularFunctionvoltage-gated calcium channel activity

CACNA1C CACNA1D CACNA1F

9.57e-0446843GO:0005245
GeneOntologyMolecularFunctionRNA polymerase II intronic transcription regulatory region sequence-specific DNA binding

POU5F1 POU5F1B

1.32e-0313842GO:0001162
GeneOntologyMolecularFunctioncytoskeletal motor activity

DNAH12 DNAH8 DNAH9 DNAH1

1.55e-03118844GO:0003774
GeneOntologyMolecularFunctioncalcium channel activity

CACNA1C CACNA1D CACNA1F TRPC1

2.15e-03129844GO:0005262
GeneOntologyMolecularFunctionintronic transcription regulatory region sequence-specific DNA binding

POU5F1 POU5F1B

2.28e-0317842GO:0001161
GeneOntologyMolecularFunctionmonoatomic cation channel activity

CACNA1C CACNA1D CACNA1F KCNG4 TRPC1 SCN9A

3.25e-03343846GO:0005261
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

CACNA1C CACNA1D CACNA1F KCNG4 TRPC1 SLC9B2 SCN9A

3.44e-03465847GO:0046873
GeneOntologyMolecularFunctioncalcium ion transmembrane transporter activity

CACNA1C CACNA1D CACNA1F TRPC1

3.80e-03151844GO:0015085
GeneOntologyMolecularFunctionvoltage-gated monoatomic cation channel activity

CACNA1C CACNA1D CACNA1F KCNG4

3.89e-03152844GO:0022843
GeneOntologyBiologicalProcessneuron projection retraction

ADCY10 DIAPH1 DIAPH2

2.69e-074853GO:0106028
GeneOntologyBiologicalProcessneuron projection development

ADCY10 PLXNA3 CACNA1F KAT2B ZNF296 SNAP91 MYCBP2 TRIM32 USP9X ENC1 VPS13A DIAPH1 DIAPH2 POU3F2 SPG11 TECTA PLS1 RUFY3

3.95e-0612858518GO:0031175
GeneOntologyBiologicalProcesscell morphogenesis

ADCY10 PLXNA3 CACNA1F SNAP91 MYCBP2 USP9X VPS13A DIAPH1 DIAPH2 PDZD8 POU3F2 SPG11 PRKDC TECTA PLS1 CDH7 RUFY3

6.21e-0611948517GO:0000902
GeneOntologyBiologicalProcesscell morphogenesis involved in neuron differentiation

ADCY10 PLXNA3 CACNA1F SNAP91 MYCBP2 USP9X DIAPH1 DIAPH2 POU3F2 SPG11 TECTA PLS1 RUFY3

1.12e-057488513GO:0048667
GeneOntologyBiologicalProcesscilium movement

ADCY10 DNAH12 SLC9B2 VPS13A CFAP69 DNAH8 DNAH9 DNAH1

1.23e-05261858GO:0003341
GeneOntologyBiologicalProcessaxon development

ADCY10 PLXNA3 CACNA1F SNAP91 MYCBP2 TRIM32 USP9X DIAPH1 DIAPH2 POU3F2 SPG11 RUFY3

1.23e-056428512GO:0061564
GeneOntologyBiologicalProcessdevelopmental growth

ADCY10 PLXNA3 CACNA1C MYCBP2 USP9X VPS13A POU3F2 SPG11 POU5F1 POU5F1B PRKDC ATM PLS1 RUFY3

1.99e-059118514GO:0048589
GeneOntologyBiologicalProcessaxonogenesis

ADCY10 PLXNA3 CACNA1F SNAP91 MYCBP2 USP9X DIAPH1 DIAPH2 POU3F2 SPG11 RUFY3

2.05e-055668511GO:0007409
GeneOntologyBiologicalProcessneuron development

ADCY10 PLXNA3 CACNA1F KAT2B ZNF296 SNAP91 MYCBP2 TRIM32 USP9X ENC1 VPS13A DIAPH1 DIAPH2 POU3F2 SPG11 TECTA PLS1 RUFY3

2.33e-0514638518GO:0048666
GeneOntologyBiologicalProcesscilium movement involved in cell motility

DNAH12 SLC9B2 VPS13A CFAP69 DNAH8 DNAH9 DNAH1

2.59e-05210857GO:0060294
GeneOntologyBiologicalProcesscilium-dependent cell motility

DNAH12 SLC9B2 VPS13A CFAP69 DNAH8 DNAH9 DNAH1

3.01e-05215857GO:0060285
GeneOntologyBiologicalProcesscilium or flagellum-dependent cell motility

DNAH12 SLC9B2 VPS13A CFAP69 DNAH8 DNAH9 DNAH1

3.01e-05215857GO:0001539
GeneOntologyBiologicalProcesspositive regulation of membrane depolarization

ADCY10 CACNA1C CACNA1D

3.64e-0516853GO:1904181
GeneOntologyBiologicalProcessregulation of plasma membrane bounded cell projection organization

ADCY10 PLXNA3 KAT2B ZNF296 SNAP91 MYCBP2 TRIM32 ENC1 DIAPH1 DIAPH2 POU3F2 PLS1 RUFY3

4.08e-058468513GO:0120035
GeneOntologyBiologicalProcessregulation of neuron projection development

ADCY10 PLXNA3 KAT2B ZNF296 SNAP91 MYCBP2 ENC1 DIAPH1 DIAPH2 POU3F2 RUFY3

4.18e-056128511GO:0010975
GeneOntologyBiologicalProcessregulation of cell projection organization

ADCY10 PLXNA3 KAT2B ZNF296 SNAP91 MYCBP2 TRIM32 ENC1 DIAPH1 DIAPH2 POU3F2 PLS1 RUFY3

5.00e-058638513GO:0031344
GeneOntologyBiologicalProcesstrophectodermal cell fate commitment

POU5F1 POU5F1B

5.02e-053852GO:0001830
GeneOntologyBiologicalProcessmulticellular organismal locomotion

DIAPH1 DIAPH2

1.00e-044852GO:0071965
GeneOntologyBiologicalProcessneuron projection morphogenesis

ADCY10 PLXNA3 CACNA1F SNAP91 MYCBP2 USP9X VPS13A DIAPH1 DIAPH2 POU3F2 SPG11 RUFY3

1.07e-048028512GO:0048812
GeneOntologyBiologicalProcessplasma membrane bounded cell projection morphogenesis

ADCY10 PLXNA3 CACNA1F SNAP91 MYCBP2 USP9X VPS13A DIAPH1 DIAPH2 POU3F2 SPG11 RUFY3

1.30e-048198512GO:0120039
GeneOntologyBiologicalProcesscell projection morphogenesis

ADCY10 PLXNA3 CACNA1F SNAP91 MYCBP2 USP9X VPS13A DIAPH1 DIAPH2 POU3F2 SPG11 RUFY3

1.41e-048268512GO:0048858
GeneOntologyBiologicalProcessgrowth

ADCY10 PLXNA3 CACNA1C MYCBP2 TRIM32 USP9X VPS13A POU3F2 SPG11 POU5F1 POU5F1B PRKDC ATM PLS1 RUFY3

1.44e-0412358515GO:0040007
GeneOntologyBiologicalProcessectodermal cell fate commitment

POU5F1 POU5F1B

1.66e-045852GO:0001712
GeneOntologyBiologicalProcesspositive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel

CACNA1C CACNA1D

1.66e-045852GO:1904879
GeneOntologyBiologicalProcessmicrotubule-based movement

ADCY10 DNAH12 SLC9B2 VPS13A SPG11 CFAP69 DNAH8 DNAH9 DNAH1

1.95e-04493859GO:0007018
GeneOntologyBiologicalProcessaxon extension

ADCY10 PLXNA3 USP9X SPG11 RUFY3

2.40e-04135855GO:0048675
GeneOntologyBiologicalProcesscalcium ion transmembrane import into cytosol

CACNA1C CACNA1D CACNA1F XCR1 TRPC1 DIAPH1

2.77e-04217856GO:0097553
GeneOntologyBiologicalProcessregulation of developmental growth

ADCY10 PLXNA3 CACNA1C MYCBP2 POU3F2 PRKDC PLS1 RUFY3

3.44e-04421858GO:0048638
GeneOntologyBiologicalProcessbranchiomotor neuron axon guidance

PLXNA3 MYCBP2

3.48e-047852GO:0021785
GeneOntologyBiologicalProcessectoderm formation

POU5F1 POU5F1B

3.48e-047852GO:0001705
GeneOntologyBiologicalProcessaxon midline choice point recognition

DIAPH1 DIAPH2

3.48e-047852GO:0016199
GeneOntologyBiologicalProcessnegative regulation of cell projection organization

PLXNA3 ZNF296 TRIM32 DIAPH1 DIAPH2 RUFY3

4.05e-04233856GO:0031345
GeneOntologyBiologicalProcessmembrane depolarization during action potential

CACNA1C CACNA1D SCN9A

4.37e-0436853GO:0086010
GeneOntologyBiologicalProcessectodermal cell differentiation

POU5F1 POU5F1B

5.93e-049852GO:0010668
GeneOntologyBiologicalProcessaxon choice point recognition

DIAPH1 DIAPH2

5.93e-049852GO:0016198
GeneOntologyBiologicalProcesscardiac muscle cell contraction

ADCY10 CACNA1C CACNA1D SCN9A

5.93e-0493854GO:0086003
GeneOntologyBiologicalProcesstelomere capping

PRKDC ATM MAP3K4

6.43e-0441853GO:0016233
GeneOntologyBiologicalProcessnegative regulation of neuron projection development

PLXNA3 ZNF296 DIAPH1 DIAPH2 RUFY3

6.73e-04169855GO:0010977
GeneOntologyBiologicalProcessintracellular calcium ion homeostasis

CACNA1C CACNA1F XCR1 CALB1 TRPC1 DIAPH1 PDZD8

7.04e-04359857GO:0006874
GeneOntologyBiologicalProcessgerm-line stem cell population maintenance

POU5F1 POU5F1B

7.39e-0410852GO:0030718
GeneOntologyBiologicalProcessendodermal cell fate specification

POU5F1 POU5F1B

9.01e-0411852GO:0001714
GeneOntologyBiologicalProcessnegative regulation of calcium ion-dependent exocytosis

POU5F1 POU5F1B

9.01e-0411852GO:0045955
GeneOntologyCellularComponentaxonemal dynein complex

DNAH12 DNAH8 DNAH9 DNAH1

2.88e-0625844GO:0005858
GeneOntologyCellularComponentcilium

TNPO1 ADCY10 CACNA1F DNAH12 GLE1 USP9X TTLL11 SLC9B2 VPS13A CFAP69 SLCO6A1 DNAH8 DNAH9 DNAH1

1.27e-058988414GO:0005929
GeneOntologyCellularComponentmotile cilium

ADCY10 DNAH12 SLC9B2 VPS13A CFAP69 SLCO6A1 DNAH8 DNAH9 DNAH1

1.27e-05355849GO:0031514
GeneOntologyCellularComponentvoltage-gated calcium channel complex

CACNA1C CACNA1D CACNA1F SLCO6A1

3.48e-0546844GO:0005891
GeneOntologyCellularComponentcation channel complex

CACNA1C CACNA1D CACNA1F KCNG4 TRPC1 SCN9A SLCO6A1

4.51e-05235847GO:0034703
GeneOntologyCellularComponent9+2 motile cilium

DNAH12 SLC9B2 VPS13A CFAP69 DNAH8 DNAH9 DNAH1

4.88e-05238847GO:0097729
GeneOntologyCellularComponentdynein complex

DNAH12 DNAH8 DNAH9 DNAH1

6.58e-0554844GO:0030286
GeneOntologyCellularComponentcalcium channel complex

CACNA1C CACNA1D CACNA1F SLCO6A1

2.14e-0473844GO:0034704
GeneOntologyCellularComponentinner dynein arm

DNAH12 DNAH1

7.03e-0410842GO:0036156
GeneOntologyCellularComponentsupramolecular fiber

CACNA1C CACNA1D KAT2B DNAH12 TRIM32 TRPC1 TTLL11 DIAPH1 DIAPH2 DNAH8 DNAH9 PLS1 DNAH1

8.16e-0411798413GO:0099512
GeneOntologyCellularComponentmonoatomic ion channel complex

CACNA1C CACNA1D CACNA1F KCNG4 TRPC1 SCN9A SLCO6A1

8.20e-04378847GO:0034702
GeneOntologyCellularComponentsupramolecular polymer

CACNA1C CACNA1D KAT2B DNAH12 TRIM32 TRPC1 TTLL11 DIAPH1 DIAPH2 DNAH8 DNAH9 PLS1 DNAH1

8.69e-0411878413GO:0099081
GeneOntologyCellularComponentL-type voltage-gated calcium channel complex

CACNA1C CACNA1D

1.03e-0312842GO:1990454
GeneOntologyCellularComponentouter dynein arm

DNAH8 DNAH9

1.03e-0312842GO:0036157
GeneOntologyCellularComponentaxoneme

DNAH12 CFAP69 DNAH8 DNAH9 DNAH1

1.49e-03207845GO:0005930
GeneOntologyCellularComponentciliary plasm

DNAH12 CFAP69 DNAH8 DNAH9 DNAH1

1.52e-03208845GO:0097014
GeneOntologyCellularComponentsperm flagellum

SLC9B2 VPS13A CFAP69 DNAH8 DNAH1

1.72e-03214845GO:0036126
DomainPOU

POU3F1 POU3F2 POU5F1 POU5F1B POU2F3

6.45e-0916835SM00352
DomainPOU_2

POU3F1 POU3F2 POU5F1 POU5F1B POU2F3

6.45e-0916835PS00465
DomainPOU_dom

POU3F1 POU3F2 POU5F1 POU5F1B POU2F3

6.45e-0916835IPR000327
DomainPOU_3

POU3F1 POU3F2 POU5F1 POU5F1B POU2F3

6.45e-0916835PS51179
DomainPou

POU3F1 POU3F2 POU5F1 POU5F1B POU2F3

6.45e-0916835PF00157
DomainPOU_1

POU3F1 POU3F2 POU5F1 POU5F1B POU2F3

6.45e-0916835PS00035
DomainPOU

POU3F1 POU3F2 POU5F1 POU5F1B POU2F3

9.10e-0917835IPR013847
DomainCAC1F_C

CACNA1C CACNA1D CACNA1F

8.46e-083833IPR031688
DomainCAC1F_C

CACNA1C CACNA1D CACNA1F

8.46e-083833PF16885
Domain-

POU3F1 POU3F2 POU5F1 POU5F1B POU2F3

1.15e-07278351.10.260.40
DomainLambda_DNA-bd_dom

POU3F1 POU3F2 POU5F1 POU5F1B POU2F3

1.68e-0729835IPR010982
DomainVDCC_L_a1su

CACNA1C CACNA1D CACNA1F

3.37e-074833IPR005446
DomainDynein_heavy_chain_D4_dom

DNAH12 DNAH8 DNAH9 DNAH1

3.51e-0714834IPR024317
DomainDynein_heavy_dom-2

DNAH12 DNAH8 DNAH9 DNAH1

3.51e-0714834IPR013602
DomainDHC_N2

DNAH12 DNAH8 DNAH9 DNAH1

3.51e-0714834PF08393
DomainAAA_8

DNAH12 DNAH8 DNAH9 DNAH1

3.51e-0714834PF12780
DomainATPase_dyneun-rel_AAA

DNAH12 DNAH8 DNAH9 DNAH1

3.51e-0714834IPR011704
DomainAAA_5

DNAH12 DNAH8 DNAH9 DNAH1

3.51e-0714834PF07728
DomainDHC_fam

DNAH12 DNAH8 DNAH9 DNAH1

4.77e-0715834IPR026983
DomainDynein_heavy_dom

DNAH12 DNAH8 DNAH9 DNAH1

4.77e-0715834IPR004273
DomainDynein_heavy

DNAH12 DNAH8 DNAH9 DNAH1

4.77e-0715834PF03028
DomainVDCC_a1su_IQ

CACNA1C CACNA1D CACNA1F

2.92e-067833IPR014873
DomainGPHH

CACNA1C CACNA1D CACNA1F

2.92e-067833PF16905
DomainGPHH_dom

CACNA1C CACNA1D CACNA1F

2.92e-067833IPR031649
DomainCa_chan_IQ

CACNA1C CACNA1D CACNA1F

2.92e-067833SM01062
DomainCa_chan_IQ

CACNA1C CACNA1D CACNA1F

2.92e-067833PF08763
DomainChannel_four-helix_dom

CACNA1C CACNA1D CACNA1F KCNG4 SCN9A

5.36e-0657835IPR027359
Domain-

CACNA1C CACNA1D CACNA1F KCNG4 SCN9A

5.36e-06578351.20.120.350
DomainVDCCAlpha1

CACNA1C CACNA1D CACNA1F

9.93e-0610833IPR002077
DomainIon_trans_dom

CACNA1C CACNA1D CACNA1F KCNG4 TRPC1 SCN9A

1.17e-05114836IPR005821
DomainIon_trans

CACNA1C CACNA1D CACNA1F KCNG4 TRPC1 SCN9A

1.17e-05114836PF00520
DomainDynein_HC_stalk

DNAH8 DNAH9 DNAH1

2.97e-0514833IPR024743
DomainMT

DNAH8 DNAH9 DNAH1

2.97e-0514833PF12777
DomainDrf_DAD

DIAPH1 DIAPH2

5.84e-053832IPR010465
DomainPOU_dom_5

POU5F1 POU5F1B

5.84e-053832IPR015585
DomainDrf_DAD

DIAPH1 DIAPH2

5.84e-053832PF06345
DomainTF_POU_3

POU3F1 POU3F2

1.16e-044832IPR016362
DomainMeTrfase

METTL2A METTL2B

1.16e-044832IPR026113
DomainARM-type_fold

TNPO1 USP9X DIAPH1 DIAPH2 ZER1 PRKDC ATM CFAP69

1.31e-04339838IPR016024
DomainFATC

PRKDC ATM

1.93e-045832PF02260
DomainMethyltransf_12

METTL2A METTL2B

2.89e-046832PF08242
DomainFAT

PRKDC ATM

2.89e-046832PS51189
DomainFATC

PRKDC ATM

2.89e-046832PS51190
DomainFAT

PRKDC ATM

2.89e-046832PF02259
DomainPIK-rel_kinase_FAT

PRKDC ATM

2.89e-046832IPR003151
DomainFATC_dom

PRKDC ATM

2.89e-046832IPR003152
DomainPIK_FAT

PRKDC ATM

2.89e-046832IPR014009
DomainMethyltransf_12

METTL2A METTL2B

2.89e-046832IPR013217
DomainFATC

PRKDC ATM

2.89e-046832SM01343
DomainDAD_dom

DIAPH1 DIAPH2

5.37e-048832IPR014767
DomainDHC_N1

DNAH8 DNAH9

5.37e-048832PF08385
DomainDAD

DIAPH1 DIAPH2

5.37e-048832PS51231
DomainDynein_heavy_dom-1

DNAH8 DNAH9

5.37e-048832IPR013594
DomainDrf_GBD

DIAPH1 DIAPH2

6.88e-049832PF06371
DomainFH3_dom

DIAPH1 DIAPH2

6.88e-049832IPR010472
DomainGTPase-bd

DIAPH1 DIAPH2

6.88e-049832IPR010473
DomainDrf_FH3

DIAPH1 DIAPH2

6.88e-049832PF06367
DomainDrf_FH3

DIAPH1 DIAPH2

6.88e-049832SM01139
DomainDrf_GBD

DIAPH1 DIAPH2

6.88e-049832SM01140
DomainGBD/FH3_dom

DIAPH1 DIAPH2

1.05e-0311832IPR014768
DomainGBD_FH3

DIAPH1 DIAPH2

1.05e-0311832PS51232
DomainGrpE_coiled_coil

TRIM32 DNAH8

1.25e-0312832IPR013805
DomainHomeobox_CS

POU3F1 POU3F2 POU5F1 POU5F1B POU2F3

1.44e-03186835IPR017970
DomainFH2

DIAPH1 DIAPH2

1.97e-0315832PS51444
DomainPI3/4_kinase_CS

PRKDC ATM

1.97e-0315832IPR018936
DomainFH2_Formin

DIAPH1 DIAPH2

1.97e-0315832IPR015425
DomainFH2

DIAPH1 DIAPH2

1.97e-0315832PF02181
DomainFH2

DIAPH1 DIAPH2

1.97e-0315832SM00498
Domain-

PRKDC ATM

2.25e-03168321.10.1070.11
DomainPI3Kc

PRKDC ATM

2.25e-0316832SM00146
DomainPI3/4_kinase_cat_dom

PRKDC ATM

2.85e-0318832IPR000403
DomainPI3_PI4_kinase

PRKDC ATM

2.85e-0318832PF00454
DomainPI3_4_KINASE_3

PRKDC ATM

2.85e-0318832PS50290
DomainPI3_4_KINASE_1

PRKDC ATM

2.85e-0318832PS00915
DomainPI3_4_KINASE_2

PRKDC ATM

2.85e-0318832PS00916
Domain-

TNPO1 USP9X ZER1 PRKDC CFAP69

3.11e-032228351.25.10.10
DomainHomeobox

POU3F1 POU3F2 POU5F1 POU5F1B POU2F3

3.89e-03234835PF00046
DomainAAA+_ATPase

DNAH12 ABCA5 DNAH8 DNAH9

3.89e-03144834IPR003593
DomainAAA

DNAH12 ABCA5 DNAH8 DNAH9

3.89e-03144834SM00382
DomainHOMEOBOX_1

POU3F1 POU3F2 POU5F1 POU5F1B POU2F3

4.03e-03236835PS00027
DomainHOX

POU3F1 POU3F2 POU5F1 POU5F1B POU2F3

4.10e-03237835SM00389
DomainHOMEOBOX_2

POU3F1 POU3F2 POU5F1 POU5F1B POU2F3

4.25e-03239835PS50071
DomainHomeobox_dom

POU3F1 POU3F2 POU5F1 POU5F1B POU2F3

4.25e-03239835IPR001356
PathwayKEGG_MEDICUS_VARIANT_SCRAPIE_CONFORMATION_PRPSC_TO_VGCC_CA2_APOPTOTIC_PATHWAY

CACNA1C CACNA1D CACNA1F

1.38e-066593M47762
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_SOD1_TO_RETROGRADE_AXONAL_TRANSPORT

DNAH12 DNAH8 DNAH9 DNAH1

4.52e-0627594M47755
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_VGCC_CA2_APOPTOTIC_PATHWAY_N01004

CACNA1C CACNA1D CACNA1F

2.45e-0514593M47692
PathwayKEGG_MEDICUS_REFERENCE_RETROGRADE_AXONAL_TRANSPORT

DNAH12 DNAH8 DNAH9 DNAH1

3.02e-0543594M47669
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_HTT_TO_RETROGRADE_AXONAL_TRANSPORT

DNAH12 DNAH8 DNAH9 DNAH1

3.63e-0545594M47670
PathwayKEGG_MEDICUS_REFERENCE_VGCC_CA2_APOPTOTIC_PATHWAY

CACNA1C CACNA1D CACNA1F

1.16e-0423593M47666
PathwayKEGG_MEDICUS_REFERENCE_CA2_ENTRY_VOLTAGE_GATED_CA2_CHANNEL

CACNA1C CACNA1D CACNA1F

1.50e-0425593M47948
PathwayPID_BARD1_PATHWAY

EWSR1 PRKDC ATM

2.36e-0429593M258
PathwayWP_MIRNAS_AND_TFS_IN_IPS_CELL_GENERATION

POU5F1 POU5F1B

4.74e-048592MM15855
Pubmed

The Pou5f1/Pou3f-dependent but SoxB-independent regulation of conserved enhancer N2 initiates Sox2 expression during epiblast to neural plate stages in vertebrates.

POU3F1 POU3F2 POU5F1 POU5F1B

4.96e-10685421185279
Pubmed

Oct4 expression is not required for mouse somatic stem cell self-renewal.

POU3F1 POU5F1 POU5F1B

1.41e-08385318159219
Pubmed

Stimulation of Oct-4 activity by Ewing's sarcoma protein.

EWSR1 POU5F1 POU5F1B

1.41e-08385315917470
Pubmed

TRIM32 modulates pluripotency entry and exit by directly regulating Oct4 stability.

TRIM32 POU5F1 POU5F1B

1.41e-08385326307407
Pubmed

Beta-adrenergic-regulated phosphorylation of the skeletal muscle Ca(V)1.1 channel in the fight-or-flight response.

CACNA1C CACNA1D CACNA1F

5.63e-08485320937870
Pubmed

The mouse T complex gene Tsga2, encoding polypeptides located in the sperm tail and anterior acrosome, maps to a locus associated with sperm motility and sperm-egg interaction abnormalities.

POU5F1 POU5F1B DNAH8

5.63e-08485316354795
Pubmed

SOX2 co-occupies distal enhancer elements with distinct POU factors in ESCs and NPCs to specify cell state.

POU3F2 POU5F1 POU5F1B

5.63e-08485323437007
Pubmed

POU family transcription factors in the nervous system.

POU3F1 POU5F1 POU5F1B

1.40e-07585310199551
Pubmed

Direct Reprogramming of Mouse Fibroblasts into Functional Skeletal Muscle Progenitors.

POU5F1 POU5F1B PRKDC

2.80e-07685329742392
Pubmed

Conserved POU binding DNA sites in the Sox2 upstream enhancer regulate gene expression in embryonic and neural stem cells.

POU3F2 POU5F1 POU5F1B

2.80e-07685315262984
Pubmed

Transcriptional regulatory networks in epiblast cells and during anterior neural plate development as modeled in epiblast stem cells.

POU3F1 POU3F2 POU5F1 POU5F1B

4.77e-072685422992956
Pubmed

Retinoic acid-stimulated sequential phosphorylation, PML recruitment, and SUMOylation of nuclear receptor TR2 to suppress Oct4 expression.

KAT2B POU5F1 POU5F1B

4.90e-07785318682553
Pubmed

Isolation of several human axonemal dynein heavy chain genes: genomic structure of the catalytic site, phylogenetic analysis and chromosomal assignment.

DNAH12 DNAH8 DNAH1

4.90e-0778539256245
Pubmed

Enhanced expression of L-type Cav1.3 calcium channels in murine embryonic hearts from Cav1.2-deficient mice.

CACNA1C CACNA1D CACNA1F

4.90e-07785312900400
Pubmed

POU homeodomain genes and myogenesis.

POU3F1 POU5F1 POU5F1B

4.90e-0778538900043
Pubmed

Different transcription factors regulate nestin gene expression during P19 cell neural differentiation and central nervous system development.

POU3F2 POU5F1 POU5F1B

7.82e-07885319147497
Pubmed

SUMOylation of Tr2 orphan receptor involves Pml and fine-tunes Oct4 expression in stem cells.

KAT2B POU5F1 POU5F1B

1.17e-06985317187077
Pubmed

Minor abnormalities of testis development in mice lacking the gene encoding the MAPK signalling component, MAP3K1.

POU5F1 POU5F1B MAP3K4

1.67e-061085321559298
Pubmed

DNMT3A-dependent DNA methylation is required for spermatogonial stem cells to commit to spermatogenesis.

ACRV1 POU5F1 POU5F1B

2.29e-061185335410378
Pubmed

NCAM induces CaMKIIalpha-mediated RPTPalpha phosphorylation to enhance its catalytic activity and neurite outgrowth.

CACNA1C CACNA1D CACNA1F

2.29e-061185318809727
Pubmed

Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development.

CACNA1C CACNA1D CACNA1F TRPC1

2.30e-063885430786075
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

MYCBP2 TRIM32 USP9X ENC1 PDZD8 LMO3 EWSR1 PRKDC ATM ZFC3H1 EIF2AK1 LRRC4 INTS8 RUFY3

2.70e-061285851435914814
Pubmed

RNA Pol II pausing facilitates phased pluripotency transitions by buffering transcription.

POU3F1 POU5F1 POU5F1B

3.05e-061285335981753
Pubmed

Essential and overlapping functions for mammalian Argonautes in microRNA silencing.

CALB1 POU5F1 POU5F1B

3.05e-061285319174539
Pubmed

Loss of the Otx2-Binding Site in the Nanog Promoter Affects the Integrity of Embryonic Stem Cell Subtypes and Specification of Inner Cell Mass-Derived Epiblast.

POU3F1 POU5F1 POU5F1B

3.05e-061285327292645
Pubmed

FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.

CACNA1C DNAH12 USP9X SCN9A DIAPH2 SPG11 ATM CDH7 MAP3K4

3.64e-0649785936774506
Pubmed

Continuing role for mouse Numb and Numbl in maintaining progenitor cells during cortical neurogenesis.

CALB1 POU3F1 POU3F2

5.03e-061485315273690
Pubmed

Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene.

DNAH12 DNAH8 DNAH1

5.03e-06148539373155
Pubmed

Multiple mouse chromosomal loci for dynein-based motility.

DNAH12 DNAH8 DNAH9 DNAH1

5.47e-06478548812413
Pubmed

Identification of mouse blastocyst genes that are downregulated by double-stranded RNA-mediated knockdown of Oct-4 expression.

POU5F1 POU5F1B

5.90e-06285215685634
Pubmed

Nuclear and chromatin reorganization in the MHC-Oct3/4 locus at developmental phases of embryonic stem cell differentiation.

POU5F1 POU5F1B

5.90e-06285216950240
Pubmed

Maternal Oct-4 is a potential key regulator of the developmental competence of mouse oocytes.

POU5F1 POU5F1B

5.90e-06285218837968
Pubmed

Synthetic lethality between mutation in Atm and DNA-PK(cs) during murine embryogenesis.

PRKDC ATM

5.90e-06285211231155
Pubmed

Cruciform Formable Sequences within Pou5f1 Enhancer Are Indispensable for Mouse ES Cell Integrity.

POU5F1 POU5F1B

5.90e-06285233810223
Pubmed

Phosphorylation of Threonine343 Is Crucial for OCT4 Interaction with SOX2 in the Maintenance of Mouse Embryonic Stem Cell Pluripotency.

POU5F1 POU5F1B

5.90e-06285228988986
Pubmed

Abnormal DNA methylation of the Oct-4 enhancer region in cloned mouse embryos.

POU5F1 POU5F1B

5.90e-06285218932201
Pubmed

A POU-domain transcription factor in early stem cells and germ cells of the mammalian embryo.

POU5F1 POU5F1B

5.90e-0628521972777
Pubmed

Mouse Oct-3 maps between the tcl12 embryonic lethal gene and the Qa gene in the H-2 complex.

POU5F1 POU5F1B

5.90e-0628521680810
Pubmed

Heterogeneous DNA methylation status of the regulatory element of the mouse Oct4 gene in adult somatic cell population.

POU5F1 POU5F1B

5.90e-06285215996113
Pubmed

Oct4 transcription factor in conjunction with valproic acid accelerates myelin repair in demyelinated optic chiasm in mice.

POU5F1 POU5F1B

5.90e-06285226804242
Pubmed

Recruitment of ATM protein to double strand DNA irradiated with ionizing radiation.

PRKDC ATM

5.90e-06285210464290
Pubmed

Conserved, developmentally regulated mechanism couples chromosomal looping and heterochromatin barrier activity at the homeobox gene A locus.

POU5F1 POU5F1B

5.90e-06285221502535
Pubmed

Regulation of the DNA Damage Response by DNA-PKcs Inhibitory Phosphorylation of ATM.

PRKDC ATM

5.90e-06285227939942
Pubmed

Phenotypic complementation establishes requirements for specific POU domain and generic transactivation function of Oct-3/4 in embryonic stem cells.

POU5F1 POU5F1B

5.90e-06285211839818
Pubmed

A novel Oct4/Pou5f1-like non-coding RNA controls neural maturation and mediates developmental effects of ethanol.

POU5F1 POU5F1B

5.90e-06285233221301
Pubmed

Developmental fate of embryonic germ cells (EGCs), in vivo and in vitro.

POU5F1 POU5F1B

5.90e-06285212641567
Pubmed

The core FH2 domain of diaphanous-related formins is an elongated actin binding protein that inhibits polymerization.

DIAPH1 DIAPH2

5.90e-06285214992721
Pubmed

A nontranscriptional role for Oct4 in the regulation of mitotic entry.

POU5F1 POU5F1B

5.90e-06285225324523
Pubmed

Novel variants of Oct-3/4 gene expressed in mouse somatic cells.

POU5F1 POU5F1B

5.90e-06285218765667
Pubmed

Oct4 dependence of chromatin structure within the extended Nanog locus in ES cells.

POU5F1 POU5F1B

5.90e-06285218283123
Pubmed

Different roles attributed to Cav1 channel subtypes in spontaneous action potential firing and fine tuning of exocytosis in mouse chromaffin cells.

CACNA1C CACNA1D

5.90e-06285221054386
Pubmed

Mechanisms of OCT4 on 3,5,3'-Tri-iodothyronine and FSH-induced Granulosa Cell Development in Female Mice.

POU5F1 POU5F1B

5.90e-06285234463738
Pubmed

Differential expression of Oct3/4 in human breast cancer and normal tissues.

POU5F1 POU5F1B

5.90e-06285229620155
Pubmed

The DNA damage response kinases DNA-dependent protein kinase (DNA-PK) and ataxia telangiectasia mutated (ATM) Are stimulated by bulky adduct-containing DNA.

PRKDC ATM

5.90e-06285221487018
Pubmed

Glutamine Metabolism Regulates the Pluripotency Transcription Factor OCT4.

POU5F1 POU5F1B

5.90e-06285227346346
Pubmed

Mesenchymal to embryonic incomplete transition of human cells by chimeric OCT4/3 (POU5F1) with physiological co-activator EWS.

EWSR1 POU5F1

5.90e-06285219559696
Pubmed

Activation of DNA Damage Response Pathways during Lytic Replication of KSHV.

PRKDC ATM

5.90e-06285226057167
Pubmed

Critical POU domain residues confer Oct4 uniqueness in somatic cell reprogramming.

POU5F1 POU5F1B

5.90e-06285226877091
Pubmed

The embryonic Octamer factor 3/4 displays distinct DNA binding specificity from those of other Octamer factors.

POU5F1 POU5F1B

5.90e-06285212615074
Pubmed

Effect of ectopic expression of homeoprotein EGAM1C on the cell morphology, growth, and differentiation in a mouse embryonic stem cell line, MG1.19 cells.

POU5F1 POU5F1B

5.90e-06285222367590
Pubmed

Targeted disruption of organic cation transporter 3 (Oct3) ameliorates ischemic brain damage through modulating histamine and regulatory T cells.

POU5F1 POU5F1B

5.90e-06285222739622
Pubmed

Oct-4: more than just a POUerful marker of the mammalian germline?

POU5F1 POU5F1B

5.90e-0628529524569
Pubmed

Transient pairing of homologous Oct4 alleles accompanies the onset of embryonic stem cell differentiation.

POU5F1 POU5F1B

5.90e-06285225748933
Pubmed

Voltage-Gated Cav1 Channels in Disorders of Vision and Hearing.

CACNA1D CACNA1F

5.90e-06285225966695
Pubmed

Expression pattern of Oct-4 in preimplantation embryos of different species.

POU5F1 POU5F1B

5.90e-06285211090438
Pubmed

A saturating mutagenesis CRISPR-Cas9-mediated functional genomic screen identifies cis- and trans-regulatory elements of Oct4 in murine ESCs.

POU5F1 POU5F1B

5.90e-06285232994224
Pubmed

Networks of Transcription Factors for Oct4 Expression in Mice.

POU5F1 POU5F1B

5.90e-06285228731785
Pubmed

Oct-4 controls cell-cycle progression of embryonic stem cells.

POU5F1 POU5F1B

5.90e-06285219968627
Pubmed

A defined Oct4 level governs cell state transitions of pluripotency entry and differentiation into all embryonic lineages.

POU5F1 POU5F1B

5.90e-06285223629142
Pubmed

Involvement of Oct3/4 in the enhancement of neuronal differentiation of ES cells in neurogenesis-inducing cultures.

POU5F1 POU5F1B

5.90e-06285212702663
Pubmed

An improved targeted cAMP sensor to study the regulation of adenylyl cyclase 8 by Ca2+ entry through voltage-gated channels.

CACNA1C CACNA1D

5.90e-06285224086669
Pubmed

Changes in the Expression of Pluripotency Factor Oct-4 and Intensity of Apoptosis in the Uterus during Spontaneous and Immune-Dependent Abortions in Mice.

POU5F1 POU5F1B

5.90e-06285235501657
Pubmed

Hierarchical Oct4 Binding in Concert with Primed Epigenetic Rearrangements during Somatic Cell Reprogramming.

POU5F1 POU5F1B

5.90e-06285226832419
Pubmed

Differential zinc permeation and blockade of L-type Ca2+ channel isoforms Cav1.2 and Cav1.3.

CACNA1C CACNA1D

5.90e-06285226049024
Pubmed

Oct4 was a novel target of Wnt signaling pathway.

POU5F1 POU5F1B

5.90e-06285222120493
Pubmed

Analysis of a transgenic Oct4 enhancer reveals high fidelity long-range chromosomal interactions.

POU5F1 POU5F1B

5.90e-06285226435056
Pubmed

Differential expression of the Oct-4 transcription factor during mouse germ cell differentiation.

POU5F1 POU5F1B

5.90e-0628529507072
Pubmed

Oct-3/4 repression accelerates differentiation of neural progenitor cells in vitro and in vivo.

POU5F1 POU5F1B

5.90e-06285215548425
Pubmed

OCT4 interprets and enhances nucleosome flexibility.

POU5F1 POU5F1B

5.90e-06285236130732
Pubmed

Computational analysis of single-cell transcriptomics data elucidates the stabilization of Oct4 expression in the E3.25 mouse preimplantation embryo.

POU5F1 POU5F1B

5.90e-06285231222057
Pubmed

DNA double-strand break formation upon UV-induced replication stress activates ATM and DNA-PKcs kinases.

PRKDC ATM

5.90e-06285219071136
Pubmed

The molecular biology of Oct-4 in the early mouse embryo.

POU5F1 POU5F1B

5.90e-0628529835353
Pubmed

Genetic polymorphisms of L-type calcium channel alpha1C and alpha1D subunit genes are associated with sensitivity to the antihypertensive effects of L-type dihydropyridine calcium-channel blockers.

CACNA1C CACNA1D

5.90e-06285219225208
Pubmed

OCT4B mediates hypoxia-induced cancer dissemination.

POU5F1 POU5F1B

5.90e-06285230209362
Pubmed

Ca1.2 and CaV1.3 neuronal L-type calcium channels: differential targeting and signaling to pCREB.

CACNA1C CACNA1D

5.90e-06285216706838
Pubmed

POU5F1 Protein and Gene Expression Analysis in Neonate and Adult Mouse Testicular Germ Cells by Immunohistochemistry and Immunocytochemistry.

POU5F1 POU5F1B

5.90e-06285234788058
Pubmed

Sumoylation of Oct4 enhances its stability, DNA binding, and transactivation.

POU5F1 POU5F1B

5.90e-06285217525163
Pubmed

Temperature-sensitive Cav1.2 calcium channels support intrinsic firing of pyramidal neurons and provide a target for the treatment of febrile seizures.

CACNA1C CACNA1D

5.90e-06285223761887
Pubmed

Non-voltage-gated L-type Ca2+ channels in human T cells: pharmacology and molecular characterization of the major alpha pore-forming and auxiliary beta-subunits.

CACNA1C CACNA1D

5.90e-06285214981074
Pubmed

Function of EWS-POU5F1 in sarcomagenesis and tumor cell maintenance.

EWSR1 POU5F1

5.90e-06285220203285
Pubmed

Auxin-degron system identifies immediate mechanisms of OCT4.

POU5F1 POU5F1B

5.90e-06285234143975
Pubmed

Acidic extracellular pH of tumors induces octamer-binding transcription factor 4 expression in murine fibroblasts in vitro and in vivo.

POU5F1 POU5F1B

5.90e-06285227302093
Pubmed

CaV1.2 and CaV1.3 channel hyperactivation in mouse islet β cells exposed to type 1 diabetic serum.

CACNA1C CACNA1D

5.90e-06285225292336
Pubmed

Roles of DNA-dependent protein kinase and ATM in cell-cycle-dependent radiation sensitivity in human cells.

PRKDC ATM

5.90e-06285212065055
Pubmed

Force via integrins but not E-cadherin decreases Oct3/4 expression in embryonic stem cells.

POU5F1 POU5F1B

5.90e-06285222037576
Pubmed

Oct4 redox sensitivity potentiates reprogramming and differentiation.

POU5F1 POU5F1B

5.90e-06285238719541
Pubmed

Ca(v)1.3 channels produce persistent calcium sparklets, but Ca(v)1.2 channels are responsible for sparklets in mouse arterial smooth muscle.

CACNA1C CACNA1D

5.90e-06285217526649
Pubmed

A unique Oct4 interface is crucial for reprogramming to pluripotency.

POU5F1 POU5F1B

5.90e-06285223376973
Pubmed

Differential role for transcription factor Oct4 nucleocytoplasmic dynamics in somatic cell reprogramming and self-renewal of embryonic stem cells.

POU5F1 POU5F1B

5.90e-06285223580657
Pubmed

Ligand-activated signal transduction in the 2-cell embryo.

CACNA1C CACNA1D

5.90e-06285212606379
InteractionPOU3F3 interactions

POU3F1 POU3F2 EWSR1 POU5F1

1.68e-0622814int:POU3F3
InteractionCACNA1D interactions

CACNA1C CACNA1D CALB1 SCN9A

2.42e-0624814int:CACNA1D
InteractionUSF1 interactions

PLXNA3 KAT2B EWSR1 PRKDC MAP3K4

2.36e-0585815int:USF1
InteractionSCN11A interactions

CACNA1C CACNA1D SCN9A

2.75e-0515813int:SCN11A
GeneFamilyPOU class homeoboxes and pseudogenes

POU3F1 POU3F2 POU5F1 POU5F1B POU2F3

1.78e-0823665523
GeneFamilyDyneins, axonemal

DNAH12 DNAH8 DNAH9 DNAH1

3.72e-0717664536
GeneFamilyCalcium voltage-gated channel subunits

CACNA1C CACNA1D CACNA1F

1.14e-0426663253
ToppCellfacs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ADCY10 CACNA1C SNAP91 ABCA5 SCN9A TECTA DNAH9

2.47e-08162847bf886e22ff2a20353499004b53f25fb9e6574896
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Hpse_Sema3c|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

PATL2 CALB1 LAMA4 CDH7 ABTB2

1.13e-051558455c7b68b59244525e3714806c205a57a2daebf423
ToppCell10x5'-GI_small-bowel-Lymphocytic_T_CD4-Tregs|GI_small-bowel / Manually curated celltypes from each tissue

ADCY10 ICOS OR2A25 RNF175 DNAH8

1.20e-05157845c44bd530e396b08f16f284e185dcb830843959ea
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CALB1 ZNF296 SLC9B2 DNAH9 DNAH1

1.28e-0515984500a157d033627d0e65c3fbd38d652c4cf56b47f6
ToppCellfacs-Marrow-T_cells-18m-Lymphocytic-late_pro_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLXNA3 PATL2 XCR1 TRPC1 DEPDC1

1.53e-051658450edd56e8d14eaeced9882dd9206ea93e8f402e8d
ToppCellfacs-Marrow-T_cells-18m-Lymphocytic-late_pro-B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLXNA3 PATL2 XCR1 TRPC1 DEPDC1

1.53e-05165845fa3aadfff6fb1e7f142db333c60c2cba02b17e6c
ToppCellCV-Moderate-7|Moderate / Virus stimulation, Condition and Cluster

CPNE8 GPR174 MYCBP2 PRKDC MAP3K4

2.64e-05185845a6c9203ce6c2892a4a369c9bcfb85720f01cbb3f
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Lymphocytic_T/NK|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

KAT2B ICOS GPR174 CD53 ATM

2.71e-051868459d576dce2c5deefef1adda16c6da7055c8d57f8f
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Lymphocytic_T/NK-T_Cell-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

KAT2B ICOS GPR174 CD53 ATM

2.71e-05186845bd3bd022b575d9b0ef90d50a5cb874085a827b77
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Lymphocytic_T/NK-T_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

KAT2B ICOS GPR174 CD53 ATM

2.71e-05186845924cc357b4c4ce8e9b05773bdab544f0b65474cc
ToppCellFetal_29-31_weeks-Immune-T_lymphocyte|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ICOS GPR174 ERAP2 CD53 ATM

3.16e-0519284569a2b04f03a1b82d067018379f7b8a116e954040
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1D ABCA5 MYCBP2 USP9X VPS13A

3.40e-051958457796ea9247f4c63762f0de8490fed08b9717fa23
ToppCellCaecum-T_cell-Tfh|T_cell / Region, Cell class and subclass

ADCY10 CACNA1F TLR1 ATM DNAH9

3.48e-05196845fe2ee5788028e6b671674f0cc50e2b6379f50976
ToppCellmild-low-quality_cells|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

PLXNA3 ABCA5 VPS13A OR2A25 ATM

3.57e-05197845e4331969bd911d1ebb5453f40a7057297b5389b4
ToppCellTracheal-10x3prime_v2-Immune_Lymphocytic-T-T_CD4-CD4_naive/CM|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

GREB1L ICOS ERAP2 CD53 OR2A25

3.57e-051978451c78bd52b94a9466459a645ac9bd14bac22c54bd
ToppCellBronchus_Control_(B.)-Stromal-TX-Mesothelial-1|Bronchus_Control_(B.) / Sample group, Lineage and Cell type

CACNA1C MLH3 INMT TXNRD3 POU3F1

3.65e-051988459b1a58fcf818f9c4ae57bbe99655f0a64fe87df7
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Layer_IV-2|World / Primary Cells by Cluster

CPNE8 CALB1 SCN9A LMO3 RUFY3

3.74e-05199845f09b40245d3d826275bbe5f508dedccc75a911bd
ToppCellmild-low-quality_cells|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

ABCA5 VPS13A ZNF407 ATM ZFC3H1

3.74e-05199845f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCellCaecum-(1)_T_cell-(16)_Tfh|Caecum / shred on region, Cell_type, and subtype

ADCY10 CACNA1F ICOS ATM DNAH9

3.74e-05199845d07d77ae426dd1164d80d7031f14befa0369d3e5
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Layer_IV|World / Primary Cells by Cluster

CPNE8 CALB1 SCN9A LMO3 RUFY3

3.74e-05199845e45448ec4db8875c8aaa9aad109a10e2905a4226
ToppCellCaecum-T_cell-Tfh|Caecum / Region, Cell class and subclass

ADCY10 CACNA1F ICOS ATM DNAH9

3.74e-05199845fb40f37d842f170ed101dfa3bffdb8f3b2c94f19
ToppCellNeuronal|World / cells hierarchy compared to all cells using T-Statistic

CACNA1C CACNA1D SNAP91 ABCA5 MYCBP2

3.83e-0520084548d801219bc771d6c7e151dc88ca4c179988de85
DrugCinnarizine

CACNA1C CACNA1D CACNA1F

4.00e-069843DB00568
DrugNimodipine

CACNA1C CACNA1D CACNA1F

4.00e-069843DB00393
Drugbenzilate

CACNA1C CACNA1D TRIM32 SCN9A TECTA

4.54e-0666845CID000201538
DrugCAS 298-57-7

CACNA1C CACNA1D CACNA1F ACRV1 PLS1

7.47e-0673845CID000002761
DrugMibefradil

CACNA1C CACNA1D CACNA1F

7.82e-0611843DB01388
DrugErgocryptine-alpha [511-09-1]; Up 200; 7uM; MCF7; HT_HG-U133A

CACNA1D ICOS ACRV1 CD53 LAMA4 TECTA DNAH9

8.70e-061988474374_UP
DrugIfosfamide [3778-73-2]; Down 200; 15.4uM; MCF7; HT_HG-U133A

PLXNA3 GLE1 TRPC1 DIAPH1 ZER1 IDH3G RUFY3

8.99e-061998473485_DN
DrugVerapamil

CACNA1C CACNA1D CACNA1F

2.62e-0516843DB00661
Drugmercury

CACNA1C CACNA1D CDAN1 CACNA1F ACRV1 TLR1 TXNRD3 DEPDC1 POU2F3 DNAH1

3.06e-055428410CID000023931
DrugKW-3049

CACNA1C CACNA1D CACNA1F SNAP91

3.49e-0550844CID000002324
Drughexamidine

DIAPH1 DIAPH2 ATM

4.50e-0519843CID000065130
DiseaseTimothy syndrome (implicated_via_orthology)

CACNA1C CACNA1D CACNA1F

7.96e-084813DOID:0060173 (implicated_via_orthology)
Diseaseautosomal dominant auditory neuropathy 1 (implicated_via_orthology)

DIAPH1 DIAPH2

2.23e-053812DOID:0060690 (implicated_via_orthology)
DiseaseManic

CACNA1C CACNA1D POU3F2 DNAH8

6.44e-0578814C0338831
DiseaseDuchenne muscular dystrophy (implicated_via_orthology)

CACNA1C CACNA1D CACNA1F

1.33e-0436813DOID:11723 (implicated_via_orthology)
DiseaseInherited neuropathies

SCN9A SPG11 ATM

1.83e-0440813C0598589
Diseasehydroxy-leucine measurement

TTLL11 ENC1 POU3F2

2.60e-0445813EFO_0005276
Diseaseresponse to virus

CD53 POU3F2

4.03e-0411812GO_0009615
DiseaseEndometrial Neoplasms

PLXNA3 MLH3 MAP3K4

5.51e-0458813C0014170
Diseaseearly cardiac repolarization measurement

MYCBP2 PDZD8

6.63e-0414812EFO_0004885
DiseaseManic Disorder

CACNA1C CACNA1D POU3F2

9.96e-0471813C0024713
DiseaseEndometrial Carcinoma

PLXNA3 MLH3 MAP3K4

1.04e-0372813C0476089
DiseaseMood Disorders

CACNA1C CACNA1D KAT2B VPS13A

1.20e-03168814C0525045
DiseaseHereditary Non-Polyposis Colon Cancer Type 2

MLH3 ATM

1.23e-0319812C1333991
DiseaseColorectal cancer, hereditary nonpolyposis, type 1

MLH3 ATM

1.23e-0319812C2936783
DiseaseDepression, Bipolar

CACNA1C CACNA1D POU3F2

1.36e-0379813C0005587
Diseaseattempted suicide

ABCA5 TRPC1 DNAH8 PLS1

1.48e-03178814EFO_0004321
DiseaseImmunologic Deficiency Syndromes

CACNA1C ATM

1.81e-0323812C0021051
DiseaseDeafness

CACNA1D PLS1

2.14e-0325812C0011053
Diseasereticulocyte count

GREB1L KAT2B USP9X ENC1 VPS13A LAMA4 EIF2AK1 WDSUB1 PLS1

2.25e-031045819EFO_0007986
DiseaseHereditary Nonpolyposis Colorectal Neoplasms

MLH3 ATM

2.32e-0326812C0009405
DiseaseAdenocarcinoma of large intestine

MLH3 PRKDC ATM

2.37e-0396813C1319315
DiseaseHereditary non-polyposis colorectal cancer syndrome

MLH3 ATM

2.50e-0327812C1112155

Protein segments in the cluster

PeptideGeneStartEntry
GIKRKLCFALSMLGN

ABCA5

1436

Q8WWZ7
DLADFFKQCGVVKMN

EWSR1

376

Q01844
KENKCLLMSFFILLL

CD53

76

P19397
AKFKQDLGFRMLNCG

BTBD11

566

A6QL63
LLFDFLEVCGNALMK

GLE1

621

Q53GS7
AFMLLFKDLIKLFAC

SNAP91

196

O60641
INLLEKFFEMKKGQC

SNAP91

216

O60641
QINKVFMFDKGCSFL

ADCY10

331

Q96PN6
EIIRCLKAFMNNKFG

DIAPH1

216

O60610
CLKAFMNNKFGLQRI

DIAPH2

236

O60879
QESEGKMCFLNKLLL

CDAN1

731

Q8IWY9
QCMLKKIFEGGKLQF

ACRV1

216

P26436
KGNMAAFLKNVCLGL

INTS8

436

Q75QN2
FTHNMLAFGLNKKLC

KIAA0513

366

O60268
RFEALQLSFKNMCKL

POU5F1B

186

Q06416
QFMFACIGVQLFKGK

CACNA1F

1011

O60840
KLFMADLQRVFTNCK

KAT2B

786

Q92831
EMLKFNLECLHKTFG

INMT

36

O95050
FLAAGKLVLLQEMCA

KCNG4

126

Q8TDN1
MGQLLKCLKDFAFNI

DDX60L

1646

Q5H9U9
FKSLADGILLCKMIN

PLS1

156

Q14651
GLMLQEADKLGCKQF

PLS1

336

Q14651
LFLLYCAIKQQMEKG

PLXNA3

1436

P51805
LLFCIQEGVKMFLKQ

MLH3

336

Q9UHC1
LRNLSMQKGFNDKFC

PDZD8

771

Q8NEN9
LDMFNQLLKKISDLC

DNAH8

701

Q96JB1
YDMAQLRFKKGQCLS

METTL2B

296

Q6P1Q9
GFQERCAKKMQLVNL

DEPDC1

371

Q5TB30
CNELLEKIMKGLNAY

DNAH12

971

Q6ZR08
FEALQLSFKNMCKLK

POU3F1

296

Q03052
RFCVGDKFFLKNNMI

LMO3

111

Q8TAP4
FNLKYLNLGMCNIKD

LRRC4

196

Q9HBW1
QKALKMILTCAGVFL

GPR174

226

Q9BXC1
GLLICRFNNFSLMKK

GREB1L

1726

Q9C091
RFEALNLSFKNMCKL

POU2F3

231

Q9UKI9
RFEALQLSFKNMCKL

POU5F1

186

Q01860
YDMAQLRFKKGQCLS

METTL2A

296

Q96IZ6
FKMQLLKGGQILCDL

ICOS

51

Q9Y6W8
ADQALQMLFKPLGKC

PATL2

406

C9JE40
NLTMSLLKLLDCFFK

DNAH1

2066

Q9P2D7
SKQDLLFLDMLKFLC

ATM

891

Q13315
KANIMKLGDGLFLQC

IDH3G

221

P51553
FMFACIGVQLFKGKL

CACNA1C

1061

Q13936
FKLLCQTFIKMGLLS

EIF2AK1

91

Q9BQI3
NFLLKFQGIKMCGKE

CALB1

176

P05937
QEKCLLFSKQFMHQG

CC2D1B

631

Q5T0F9
NKGACILNMLKDFLG

ERAP2

456

Q6P179
ALFLLGGQTFMCDKL

ENC1

296

O14682
QIQDFKMDLASLCLK

DNAH9

2856

Q9NYC9
MKLGKVEFCHFLQLI

CDH7

1

Q9ULB5
NQKKFCNLILGIMVE

CFAP69

621

A5D8W1
QFMFACIGVQLFKGK

CACNA1D

1026

Q01668
LMQFCANKLDKKDFF

CPNE8

161

Q86YQ8
QKLNHFFCEIMAVLK

OR2A25

171

A4D2G3
CMKGFQFQKKDFNLL

LAMA4

1201

Q16363
LKEIDFKACLAQMFF

OR52N1

91

Q8NH53
QAGKLFCDIAGMLLK

MAP3K4

746

Q9Y6R4
LLVGLNVIDANFCMK

RUFY3

211

Q7L099
NLRSLENKPVFMFCK

TAS2R33

251

P0DSN6
QFMKKLLTCNGVYLN

USP9X

2011

Q93008
NIQQCLFLKKMGAKG

TRIM32

351

Q13049
FNKDKAISFLGCMVQ

OR5L1

86

Q8NGL2
TFLMVCFAGFNLKEK

SLC9B2

436

Q86UD5
LIGLQLFMGNLKHKC

SCN9A

261

Q15858
LFMGNLKHKCFRNSL

SCN9A

266

Q15858
NCFKVMFLQRKGQVI

SIN3B

951

O75182
NKTKMAFLLVGICFL

SLCO6A1

661

Q86UG4
NKLGILDMFLGCIAK

MYCBP2

4101

O75592
FEALQLSFKNMCKLK

POU3F2

311

P20265
FNKDKAISFLGCMVQ

OR5L2

86

Q8NGL0
ICKEFGNMSQLKFLG

TLR1

131

Q15399
CEGFFLKHMKALLEQ

ABTB2

971

Q8N961
KNMGFDVKGQLLKIC

SPG11

746

Q96JI7
MEVSISKCKLFQLGF

TECTA

1811

O75443
LARQCKMFAKDLLAQ

TRPC1

261

P48995
VLGDFLCKLLNMIFS

XCR1

96

P46094
CFQILGFDILLMKNL

TTLL11

511

Q8NHH1
NCEMFLNFNGMKLFL

ZER1

561

Q7Z7L7
LNFNGMKLFLDCLKE

ZER1

566

Q7Z7L7
SKCGLVMLNNLVKAF

VPS13A

1846

Q96RL7
TMCGFNLFFKIKARD

RNF175

161

Q8N4F7
CNSLMKKLQHLFAFL

USP38

481

Q8NB14
DLRDMFCKILHGFKN

TNPO1

856

Q92973
LKFLCIFLEKMGQKI

PRKDC

86

P78527
FAAAMKCGLTKQLLD

TXNRD3

596

Q86VQ6
FKKMVQGVLQFAVCD

ZNF407

2076

Q9C0G0
LCAQDLKDLVGIFKM

WDSUB1

341

Q8N9V3
MCKFFILQNRGDNLL

ZFC3H1

1676

O60293
ITAFMDHKKLGCQLF

ZNF296

126

Q8WUU4
TQMKCFLFGLLNEDR

NLRP14

526

Q86W24