Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionphosphatidylinositol-4,5-bisphosphate binding

WASHC2C SNX18 MYO1B WASHC2A

2.61e-0495654GO:0005546
GeneOntologyMolecularFunctionretromer complex binding

WASHC2C WASHC2A

4.62e-0410652GO:1905394
GeneOntologyMolecularFunctionphosphatidylinositol-3,4,5-trisphosphate binding

WASHC2C MYO1B WASHC2A

5.45e-0449653GO:0005547
GeneOntologyMolecularFunctionphosphatidylinositol bisphosphate binding

WASHC2C SNX18 MYO1B WASHC2A

6.53e-04121654GO:1902936
GeneOntologyMolecularFunctioncell adhesion molecule binding

CIB2 CCN1 EPHA2 NISCH SH3GL1 MYO1B ITGA9 CNTN1

7.01e-04599658GO:0050839
GeneOntologyBiologicalProcessprotein depolymerization

WASHC2C SPTB SH3GL1 SH3GL2 ASPH KIF2C

6.14e-06144656GO:0051261
GeneOntologyCellularComponentsarcoplasmic reticulum

HK2 ASPH CASQ1 RYR2

1.44e-0488634GO:0016529
GeneOntologyCellularComponentsarcoplasmic reticulum membrane

ASPH CASQ1 RYR2

3.38e-0445633GO:0033017
GeneOntologyCellularComponentsarcoplasm

HK2 ASPH CASQ1 RYR2

3.90e-04114634GO:0016528
GeneOntologyCellularComponentcuticular plate

CIB2 PVALB

6.82e-0413632GO:0032437
GeneOntologyCellularComponentWASH complex

WASHC2C WASHC2A

9.15e-0415632GO:0071203
DomainFAM21

WASHC2C WASHC2A

1.16e-052642IPR027308
DomainFAM21/CAPZIP

WASHC2C WASHC2A

3.46e-053642IPR029341
DomainCAP-ZIP_m

WASHC2C WASHC2A

3.46e-053642PF15255
DomainEF-hand_1

CIB2 PVALB SDF4 RYR2 RAB11FIP3

1.73e-04152645PF00036
DomainEFh

CIB2 PVALB SDF4 RYR2 RAB11FIP3

2.07e-04158645SM00054
DomainEF_HAND_2

CIB2 PVALB SDF4 RYR2 RAB11FIP3

1.17e-03231645PS50222
DomainSpectrin_alpha_SH3

SH3GL1 SH3GL2

1.18e-0315642IPR013315
DomainBAR

SH3GL1 SH3GL2

1.18e-0315642SM00721
DomainBAR

SH3GL1 SH3GL2

1.18e-0315642PF03114
DomainEF_hand_dom

CIB2 PVALB SDF4 RYR2 RAB11FIP3

1.19e-03232645IPR002048
DomainBAR_dom

SH3GL1 SH3GL2

1.34e-0316642IPR004148
DomainHMG_box_dom

PBRM1 SH3GL2 CHD4

1.44e-0365643IPR009071
DomainBAR

SH3GL1 SH3GL2

1.90e-0319642PS51021
Domain-

CIB2 PVALB SDF4 RYR2 RAB11FIP3

2.00e-032616451.10.238.10
DomainPHD

CHD4 UHRF2 SP110

2.17e-0375643PF00628
Domainfn3

FNDC1 EPHA2 IGSF9B CNTN1

2.31e-03162644PF00041
DomainZnf_PHD-finger

CHD4 UHRF2 SP110

2.52e-0379643IPR019787
DomainEF-hand-dom_pair

CIB2 PVALB SDF4 RYR2 RAB11FIP3

3.01e-03287645IPR011992
DomainEF-hand_7

CIB2 PVALB SDF4

3.10e-0385643PF13499
DomainPHD

CHD4 UHRF2 SP110

3.53e-0389643SM00249
DomainFN3

FNDC1 EPHA2 IGSF9B CNTN1

3.73e-03185644SM00060
DomainZnf_PHD

CHD4 UHRF2 SP110

3.76e-0391643IPR001965
DomainVWC

CCN1 BMPER

4.13e-0328642PF00093
DomainZF_PHD_2

CHD4 UHRF2 SP110

4.24e-0395643PS50016
DomainZF_PHD_1

CHD4 UHRF2 SP110

4.37e-0396643PS01359
Domain-

SH3GL1 SH3GL2

4.73e-03306421.20.1270.60
DomainAH/BAR-dom

SH3GL1 SH3GL2

4.73e-0330642IPR027267
DomainFN3

FNDC1 EPHA2 IGSF9B CNTN1

4.83e-03199644PS50853
DomainEF_HAND_1

CIB2 PVALB SDF4 RAB11FIP3

5.27e-03204644PS00018
DomainFN3_dom

FNDC1 EPHA2 IGSF9B CNTN1

5.73e-03209644IPR003961
DomainVWFC_1

CCN1 BMPER

6.76e-0336642PS01208
DomainBROMODOMAIN_1

PBRM1 SP110

7.13e-0337642PS00633
DomainVWC

CCN1 BMPER

7.51e-0338642SM00214
DomainVWFC_2

CCN1 BMPER

7.51e-0338642PS50184
DomainBROMODOMAIN_2

PBRM1 SP110

8.70e-0341642PS50014
DomainBROMO

PBRM1 SP110

9.11e-0342642SM00297
DomainBromodomain

PBRM1 SP110

9.11e-0342642IPR001487
Domain-

PBRM1 SP110

9.11e-03426421.20.920.10
DomainVWF_dom

CCN1 BMPER

9.11e-0342642IPR001007
DomainPX

NISCH SNX18

9.97e-0344642SM00312
PathwayREACTOME_STIMULI_SENSING_CHANNELS

BSND RIPK1 ASPH CASQ1 RYR2

3.09e-0599525MM14910
PathwayREACTOME_STIMULI_SENSING_CHANNELS

BSND RIPK1 ASPH CASQ1 RYR2

4.29e-05106525M27200
PathwayKEGG_MEDICUS_REFERENCE_CARDIAC_TYPE_VGCC_RYR_SIGNALING

ASPH CASQ1 RYR2

6.01e-0521523M47950
PathwayREACTOME_EGFR_DOWNREGULATION

PTPN3 SH3GL1 SH3GL2

1.98e-0431523MM14705
PathwayREACTOME_EGFR_DOWNREGULATION

PTPN3 SH3GL1 SH3GL2

1.98e-0431523M16597
Pubmed

Functional proteomics mapping of a human signaling pathway.

JUNB USP5 ARNT PBRM1 MYCBP2 HTATSF1 SDF4 MPHOSPH10 PUM1 UHRF2 RYR2

1.21e-08591651115231748
Pubmed

Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.

PBRM1 UTP25 MYCBP2 NISCH SNX18 RBM6 CHD4 MPHOSPH10 AGPS

1.31e-0744065934244565
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

USP5 PBRM1 UTP25 MYCBP2 RBM6 MYO1B CHD4 MPHOSPH10 PUM1 RAD21

3.59e-07653651022586326
Pubmed

Phosphatidylinositol 4-kinase IIα function at endosomes is regulated by the ubiquitin ligase Itch.

SH3GL1 SH3GL2 SNX18

1.76e-061365323146885
Pubmed

Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.

USP5 PBRM1 HK2 WASHC2C CHD4 KIF2C RAD21

2.94e-0633265732786267
Pubmed

Identification of a novel Rev-interacting cellular protein.

WASHC2C WASHC2A

3.44e-06265215847701
Pubmed

Control of HIV replication in astrocytes by a family of highly conserved host proteins with a common Rev-interacting domain (Risp).

WASHC2C WASHC2A

3.44e-06265220827171
Pubmed

FAM21 is critical for TLR2/CLEC4E-mediated dendritic cell function against Candida albicans.

WASHC2C WASHC2A

3.44e-06265236717248
Pubmed

Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.

ERLIN2 PBRM1 WASHC2C CLIP2 ASPH MYO1B CHD4 MPHOSPH10 PUM1 RAD21

3.71e-06847651035850772
Pubmed

PROTAC-mediated degradation reveals a non-catalytic function of AURORA-A kinase.

MYCBP2 SH3GL1 RBM6 MPHOSPH10 SP110 FKBP5

7.03e-0624765632989298
Pubmed

LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.

USP5 ERLIN2 HK2 CCN1 EPHA2 NISCH ASPH PUM1 HEATR3 YIPF3

9.42e-06942651031073040
Pubmed

Single point mutation in Bin/Amphiphysin/Rvs (BAR) sequence of endophilin impairs dimerization, membrane shaping, and Src homology 3 domain-mediated partnership.

SH3GL1 SH3GL2

1.03e-05365222167186
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

GDA PBRM1 CLIP2 MYCBP2 NFATC3 NISCH SH3GL2 CHD4 CNTN1 KIF2C

1.14e-05963651028671696
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

JUNB WASHC2C MYCBP2 ASPH RBM6 PRPF38B CHD4 FKBP5 ZFX

1.34e-0577465915302935
Pubmed

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.

ARNT WASHC2C NFATC3 RBM6 MYO1B WASHC2A FKBP5 KIF2C

1.38e-0558865838580884
Pubmed

Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.

JUNB USP5 PBRM1 WDR55 HTATSF1 PRPF38B CHD4 UHRF2 FKBP5 RAD21

1.78e-051014651032416067
Pubmed

EEN encodes for a member of a new family of proteins containing an Src homology 3 domain and is the third gene located on chromosome 19p13 that fuses to MLL in human leukemia.

SH3GL1 SH3GL2

2.06e-0546529122235
Pubmed

Synaptojanin and Endophilin Mediate Neck Formation during Ultrafast Endocytosis.

SH3GL1 SH3GL2

2.06e-05465229953872
Pubmed

Endophilin-A coordinates priming and fusion of neurosecretory vesicles via intersectin.

SH3GL1 SH3GL2

2.06e-05465232152276
Pubmed

Expression and protein-binding studies of the EEN gene family, new interacting partners for dynamin, synaptojanin and huntingtin proteins.

SH3GL1 SH3GL2

2.06e-05465210816441
Pubmed

Protein protein interactions between triadin and calsequestrin are involved in modulation of sarcoplasmic reticulum calcium release in cardiac myocytes.

ASPH RYR2

2.06e-05465217569730
Pubmed

LRRK2 controls an EndoA phosphorylation cycle in synaptic endocytosis.

SH3GL1 SH3GL2

2.06e-05465222998870
Pubmed

Viral gene transfer rescues arrhythmogenic phenotype and ultrastructural abnormalities in adult calsequestrin-null mice with inherited arrhythmias.

ASPH RYR2

2.06e-05465222298808
Pubmed

Metastasis-associated protein 3 (MTA3) regulates G2/M progression in proliferating mouse granulosa cells.

CHD4 RAD21

2.06e-05465222075476
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

JUNB ARNT PBRM1 ABRAXAS1 ASPH HTATSF1 CHD4 SP110 ZFX KIF2C RAD21

2.56e-051294651130804502
Pubmed

Developmental diversification of cortical inhibitory interneurons.

PBRM1 CCN1 MYT1 PVALB

2.63e-059165429513653
Pubmed

STK40 Is a Pseudokinase that Binds the E3 Ubiquitin Ligase COP1.

JUNB NFATC3 FKBP5

2.70e-053165328089446
Pubmed

Alix (ALG-2-interacting protein X), a protein involved in apoptosis, binds to endophilins and induces cytoplasmic vacuolization.

SH3GL1 SH3GL2

3.43e-05565212034747
Pubmed

Calmodulin Promotes N-BAR Domain-Mediated Membrane Constriction and Endocytosis.

SH3GL1 SH3GL2

3.43e-05565227093085
Pubmed

Complementary DNA cloning, genomic characterization and expression analysis of a mammalian gene encoding histidine-rich calcium binding protein.

ASPH RYR2

3.43e-05565215777620
Pubmed

Upregulation of Parkin in endophilin mutant mice.

SH3GL1 SH3GL2

3.43e-05565225471590
Pubmed

CHD4 Promotes Breast Cancer Progression as a Coactivator of Hypoxia-Inducible Factors.

ARNT CHD4

3.43e-05565232699137
Pubmed

Endophilin-A Deficiency Induces the Foxo3a-Fbxo32 Network in the Brain and Causes Dysregulation of Autophagy and the Ubiquitin-Proteasome System.

SH3GL1 SH3GL2

3.43e-05565227720640
Pubmed

Chromosome mapping of five human cardiac and skeletal muscle sarcoplasmic reticulum protein genes.

CASQ1 RYR2

3.43e-0556528406504
Pubmed

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.

JUNB ARNT MYCBP2 PRPF38B CHD4 UHRF2 FKBP5 HEATR3 KIF2C RAD21

3.63e-051103651034189442
Pubmed

A Single Adaptable Cochaperone-Scaffold Complex Delivers Nascent Iron-Sulfur Clusters to Mammalian Respiratory Chain Complexes I-III.

USP5 HK2 RIPK1 NISCH ASPH SDF4 AGPS HEATR3

4.12e-0568665828380382
Pubmed

Binding properties of SH3 peptide ligands identified from phage-displayed random peptide libraries.

SH3GL1 SH3GL2

5.13e-0566529238627
Pubmed

The interaction between EEN and Abi-1, two MLL fusion partners, and synaptojanin and dynamin: implications for leukaemogenesis.

SH3GL1 SH3GL2

5.13e-05665210764144
Pubmed

Role of dynamin, synaptojanin, and endophilin in podocyte foot processes.

SH3GL1 SH3GL2

5.13e-05665223187129
Pubmed

A novel SH3-containing human gene family preferentially expressed in the central nervous system.

SH3GL1 SH3GL2

5.13e-0566529169142
Pubmed

Molecular basis of interactions between SH3 domain-containing proteins and the proline-rich region of the ubiquitin ligase Itch.

SH3GL1 SH3GL2

5.13e-05665228235806
Pubmed

TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.

USP5 ARNT PBRM1 CHD4 FKBP5

5.87e-0522065535785414
Pubmed

A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.

ERLIN2 MYCBP2 EPHA2 SH3GL1 SNX18 MPHOSPH10 PUM1 WASHC2A

6.02e-0572465836232890
Pubmed

Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.

PBRM1 RIPK1 SNX18 SDF4 CHD4 ZFX KIF2C

6.17e-0553365730554943
Pubmed

A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.

JUNB USP5 ERLIN2 HK2 SH3GL1 ASPH MYO1B SDF4 CHD4 FKBP5 HEATR3

6.75e-051440651130833792
Pubmed

Quality Control of ER Membrane Proteins by the RNF185/Membralin Ubiquitin Ligase Complex.

ERLIN2 RBM6 HTATSF1

6.79e-054265332738194
Pubmed

Endophilin A1 regulates dendritic spine morphogenesis and stability through interaction with p140Cap.

SH3GL1 SH3GL2

7.18e-05765225771685
Pubmed

The SH3 domains of endophilin and amphiphysin bind to the proline-rich region of synaptojanin 1 at distinct sites that display an unconventional binding specificity.

SH3GL1 SH3GL2

7.18e-05765210542231
Pubmed

Synaptojanin forms two separate complexes in the nerve terminal. Interactions with endophilin and amphiphysin.

SH3GL1 SH3GL2

7.18e-0576529341169
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

USP5 EOGT ERLIN2 CCN1 MYCBP2 EPHA2 ASPH SDF4 BMPER KIF2C

7.40e-051201651035696571
Pubmed

SNX27-driven membrane localisation of OTULIN antagonises linear ubiquitination and NF-κB signalling activation.

USP5 WASHC2C RIPK1 RBM6 HTATSF1 WASHC2A

7.62e-0537865634315543
Pubmed

HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.

USP5 RBM6 HTATSF1 ULK4 CHD4 MPHOSPH10 PUM1 KIF2C

7.98e-0575465835906200
Pubmed

The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.

PBRM1 MYCBP2 ASPH RBM6 CHD4 MPHOSPH10 KIF2C RAD21

8.36e-0575965835915203
Pubmed

MYC multimers shield stalled replication forks from RNA polymerase.

JUNB UTP25 SH3GL1 RBM6 MYO1B CHD4 MPHOSPH10 KIF2C RAD21

8.99e-0598965936424410
Pubmed

SH3 domains from a subset of BAR proteins define a Ubl-binding domain and implicate parkin in synaptic ubiquitination.

SH3GL1 SH3GL2

9.56e-05865220064468
Pubmed

A FAM21-containing WASH complex regulates retromer-dependent sorting.

WASHC2C WASHC2A

9.56e-05865219922874
Pubmed

Def-2, -3, -6 and -8, novel mouse genes differentially expressed in the haemopoietic system.

HK2 RBM6

9.56e-05865210460589
Pubmed

Diverse alternative back-splicing and alternative splicing landscape of circular RNAs.

ASPH ZFX

9.56e-05865227365365
Pubmed

Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors.

SH3GL1 SH3GL2

9.56e-05865211894095
Pubmed

Ataxin-2 and huntingtin interact with endophilin-A complexes to function in plastin-associated pathways.

SH3GL1 SH3GL2

9.56e-05865216115810
Pubmed

Sequential docking, molecular differentiation, and positioning of T-Tubule/SR junctions in developing mouse skeletal muscle.

CASQ1 RYR2

9.56e-05865211784029
Pubmed

Recruitment of endophilin to clathrin-coated pit necks is required for efficient vesicle uncoating after fission.

SH3GL1 SH3GL2

9.56e-05865222099461
Pubmed

Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.

ARNT ERLIN2 CCN1 EPHA2 SH3GL1 MYO1B PRPF38B CHD4 MPHOSPH10 FKBP5

1.01e-041247651027684187
Pubmed

Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome.

WASHC2C NFATC3 WBP1L WASHC2A YIPF3

1.26e-042596559811942
Pubmed

Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.

SPTB PVALB SH3GL2 MYO1B FHOD3 IGSF9B SP110 RYR2

1.35e-0481465823251661
Pubmed

Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.

GDA EOGT ERLIN2 CCN1 MYCBP2 ASPH MYO1B SDF4 PRPF38B AGPS

1.39e-041297651033545068
Pubmed

Bidirectional perisomatic inhibitory plasticity of a Fos neuronal network.

JUNB PVALB

1.53e-041065233299180
Pubmed

SRp38 regulates alternative splicing and is required for Ca(2+) handling in the embryonic heart.

ASPH RYR2

1.53e-041065219386262
Pubmed

Subtractive hybridisation screen identifies sexually dimorphic gene expression in the embryonic mouse gonad.

NISCH CHD4 PUM1

1.70e-045765314595844
Pubmed

ZMYM3 regulates BRCA1 localization at damaged chromatin to promote DNA repair.

PBRM1 ABRAXAS1 HTATSF1 CHD4

1.83e-0415065428242625
Pubmed

Non-proteolytic ubiquitination of OTULIN regulates NF-κB signaling pathway.

HK2 PUM1

1.87e-041165231504727
Pubmed

High levels of structural disorder in scaffold proteins as exemplified by a novel neuronal protein, CASK-interactive protein1.

EPHA2 MYO1B

1.87e-041165219523119
Pubmed

Label-Free Interactome Analysis Revealed an Essential Role of CUL3-KEAP1 Complex in Mediating the Ubiquitination and Degradation of PHD2.

ARNT FKBP5

1.87e-041165231763849
Pubmed

Characterization of Endophilin B1b, a brain-specific membrane-associated lysophosphatidic acid acyl transferase with properties distinct from endophilin A1.

SH3GL1 SH3GL2

1.87e-041165212456676
Pubmed

OncoPPi-informed discovery of mitogen-activated protein kinase kinase 3 as a novel binding partner of c-Myc.

ARNT EPHA2

1.87e-041165228628118
Pubmed

The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met.

SH3GL1 SH3GL2

1.87e-041165211894096
Pubmed

The Hippo pathway component Wwc2 is a key regulator of embryonic development and angiogenesis in mice.

JUNB CCN1

1.87e-041165233483469
Pubmed

Maternal bile acid transporter deficiency promotes neonatal demise.

JUNB HK2 CCN1

1.88e-045965326416771
Pubmed

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.

JUNB ARNT HK2 NISCH WDR55 CHD4 PUM1 KIF2C

1.92e-0485765825609649
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

JUNB MYCBP2 NISCH RAP1GAP2 ULK4 SDF4 PUM1 WASHC2A RAB11FIP3

2.07e-04110565935748872
Pubmed

The functional interactome landscape of the human histone deacetylase family.

HHIP ERLIN2 MYCBP2 CHD4 AGPS

2.10e-0428965523752268
Pubmed

HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.

PBRM1 CLIP2 EPHA2 ASPH WDR55 MYO1B SDF4 PRPF38B CHD4 AGPS

2.18e-041371651036244648
Pubmed

Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia.

ERLIN2 WASHC2C CASQ1 PUM1 WASHC2A

2.21e-0429265512819125
Pubmed

The Arp2/3 activator WASH controls the fission of endosomes through a large multiprotein complex.

WASHC2C WASHC2A

2.24e-041265219922875
Pubmed

Loss of strumpellin in the melanocytic lineage impairs the WASH Complex but does not affect coat colour.

WASHC2C WASHC2A

2.24e-041265227390154
Pubmed

Recapitulation of two genomewide association studies on blood pressure and essential hypertension in the Korean population.

ULK4 ITGA9

2.24e-041265220414254
Pubmed

Proteomic Analysis Reveals a Role for RSK in p120-catenin Phosphorylation and Melanoma Cell-Cell Adhesion.

WASHC2C EPHA2 NISCH RAD21

2.35e-0416065431678930
Pubmed

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.

RIPK1 MYCBP2 MPHOSPH10 AGPS HEATR3

2.42e-0429865532353859
Pubmed

A protein-RNA interaction atlas of the ribosome biogenesis factor AATF.

UTP25 MYO1B MPHOSPH10 PUM1

2.46e-0416265431363146
Pubmed

R2TP/Prefoldin-like component RUVBL1/RUVBL2 directly interacts with ZNHIT2 to regulate assembly of U5 small nuclear ribonucleoprotein.

ASPH HTATSF1 PRPF38B CHD4 AGPS

2.50e-0430065528561026
Pubmed

A bead-based approach for large-scale identification of in vitro kinase substrates.

WDR55 HTATSF1 CHD4 MPHOSPH10

2.52e-0416365422113938
Pubmed

Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.

ERLIN2 HK2 WASHC2C MYCBP2 SH3GL1 SH3GL2 PRPF38B WASHC2A RYR2

2.58e-04113965936417873
Pubmed

Biological insights from 108 schizophrenia-associated genetic loci.

PBRM1 NFATC3 NISCH WBP1L IGSF9B

2.62e-0430365525056061
Pubmed

Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.

PBRM1 WASHC2C IGSF9B WASHC2A ZFX RAD21

2.63e-0447565631040226
Pubmed

hnRNP U protein is required for normal pre-mRNA splicing and postnatal heart development and function.

ASPH RYR2

2.65e-041365226039991
Pubmed

The ubiquitin-specific protease USP36 SUMOylates EXOSC10 and promotes the nucleolar RNA exosome function in rRNA processing.

PBRM1 UTP25 WDR55 SDF4 CHD4 MPHOSPH10

2.87e-0448365636912080
Pubmed

Human transcription factor protein interaction networks.

JUNB ARNT ERLIN2 PBRM1 NFATC3 RBM6 MYO1B PUM1 WASHC2A RAD21

3.03e-041429651035140242
Pubmed

Comparative interactome analysis of α-arrestin families in human and Drosophila.

USP5 ERLIN2 EPHA2 MYO1B CNTN1

3.04e-0431365538270169
Pubmed

MED12 regulates a transcriptional network of calcium-handling genes in the heart.

CASQ1 RYR2

3.08e-041465228724790
Pubmed

Developmental abnormalities of neuronal structure and function in prenatal mice lacking the prader-willi syndrome gene necdin.

PVALB CNTN1

3.08e-041465215972963
InteractionAZU1 interactions

UTP25 SH3GL1 SH3GL2 RAD21

7.83e-0723644int:AZU1
InteractionAURKA interactions

USP5 MYCBP2 EPHA2 MYT1 SH3GL1 SNX18 RBM6 MPHOSPH10 SP110 FKBP5 KIF2C

1.08e-056966411int:AURKA
InteractionITCH interactions

JUNB USP5 RIPK1 EPHA2 WBP1L SH3GL1 SH3GL2 SNX18

1.64e-05356648int:ITCH
InteractionSIRT6 interactions

PBRM1 UTP25 MYCBP2 NISCH SNX18 RBM6 CHD4 MPHOSPH10 AGPS RAD21

2.67e-056286410int:SIRT6
GeneFamilyWASH complex

WASHC2C WASHC2A

8.63e-0564421331
GeneFamilyEF-hand domain containing

CIB2 PVALB SDF4 RYR2 RAB11FIP3

1.84e-04219445863
GeneFamilyN-BAR domain containing

SH3GL1 SH3GL2

3.76e-04124421289
GeneFamilyFibronectin type III domain containing

FNDC1 EPHA2 IGSF9B CNTN1

6.09e-04160444555
GeneFamilyPHD finger proteins

CHD4 UHRF2 SP110

1.36e-039044388
CoexpressionMARTINEZ_RB1_TARGETS_UP

JUNB HHIP WASHC2C CCN1 ASPH RBM6 CASQ1 CHD4 ITGA9 PUM1 WASHC2A RAD21

2.43e-077416512MM1037
CoexpressionMARTINEZ_RB1_TARGETS_UP

JUNB HHIP CCN1 ASPH RBM6 CASQ1 CHD4 ITGA9 PUM1 WASHC2A RAD21

9.56e-076906511M12224
CoexpressionTABULA_MURIS_SENIS_HEART_AND_AORTA_FIBROBLAST_OF_CARDIAC_TISSUE_AGEING

JUNB GDA PDE1A HK2 CCN1 MYCBP2 SDF4

1.65e-05327657MM3714
CoexpressionDORN_ADENOVIRUS_INFECTION_12HR_UP

JUNB CCN1 EPHA2

4.56e-0528653M10668
CoexpressionMARTINEZ_TP53_TARGETS_UP

WASHC2C CCN1 ASPH RBM6 CASQ1 ITGA9 PUM1 WASHC2A RAD21

5.17e-05694659MM1039
CoexpressionAtlasDevelopingLowerUrinaryTract_P1_bladder_J_emap-30374_top-relative-expression-ranked_1000

HHIP GDA FNDC1 CCN1 MYCBP2 SH3GL2 RAP1GAP2 CASQ1 FHOD3 RYR2 CNTN1

2.04e-057726511gudmap_developingLowerUrinaryTract_P1_bladder_1000_J
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GDA PDE1A SH3GL2 RAP1GAP2 BMPER RYR2

2.83e-0718664684ba666237c18189d7e7556bd92dd953af733c00
ToppCellP07-Mesenchymal-myocytic_cell|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

JUNB HHIP PDE1A FNDC1 CCN1 ITGA9

3.96e-07197646378299fe2ec6ed2fc858febb78ff1ac0898e457d
ToppCellP07-Mesenchymal-myocytic_cell-aortic_smooth_muscle_cell|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

JUNB HHIP PDE1A FNDC1 CCN1 ITGA9

3.96e-07197646b1135378d768fbbe62a75747d1e8653d35252187
ToppCellAdult-Mesenchymal-vascular_smooth_muscle_cell-D175|Adult / Lineage, Cell type, age group and donor

PDE1A CCN1 SPTB FHOD3 IGSF9B

4.24e-06167645c4e321bb87512ea839f324c92c0f1afea891483f
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GDA PDE1A SH3GL2 RAP1GAP2 BMPER

5.18e-06174645e4d65fe121a32ac4cdd6312e7b8f867f0852e991
ToppCellCOVID-19-kidney-tDL|COVID-19 / Disease (COVID-19 only), tissue and cell type

PTPN3 GDA SH3GL2 FHOD3 RAB11FIP3

6.11e-06180645864c895b5eaedefae86f5829fa344f7b686fb59f
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

GDA PDE1A RAP1GAP2 FHOD3 IGSF9B

6.27e-0618164558f76bb9ea1518c2b629a0256a3f6595a9278152
ToppCellFrontal_cortex-Neuronal-Excitatory|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

GDA PDE1A MYCBP2 SH3GL2 RAP1GAP2

6.79e-061846456e17c8151d6dc543de16d804db956c63c3fda414
ToppCellLPS_only-Epithelial_alveolar|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PTPN3 HHIP EPHA2 SH3GL2 ITGA9

7.16e-06186645e0a2ea4b46af742bc7c9b2072bb85e27d5c92712
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

GDA SH3GL2 FHOD3 FKBP5 RAB11FIP3

7.16e-061866455784d255e9ca449d375d81938d0fbbd8a7eb44f6
ToppCellLPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

HHIP FNDC1 FHOD3 ITGA9 RYR2

7.54e-061886453177b2c1723268d330d3e9f24f9e24492ace6286
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PDE1A SH3GL2 RAP1GAP2 BMPER RYR2

7.74e-06189645a75226616340045b581d08429d2e123e041dee55
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GDA PDE1A SH3GL2 BMPER RYR2

7.94e-06190645d594da827e3c16644952b9589cc12b947ce36279
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GDA PDE1A SH3GL2 BMPER RYR2

7.94e-0619064549e09cdb843b3d889a06a811aa5affae68b25a75
ToppCellControl-Stromal_mesenchymal|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

HHIP FNDC1 FHOD3 ITGA9 RYR2

8.14e-0619164514057205ddb9b4bbc582d1358d13cf36d979a61b
ToppCellControl-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

HHIP FNDC1 FHOD3 ITGA9 RYR2

8.14e-06191645b133ee1c0e58d00ddd2e4e05b01fd04947524c18
ToppCelldroplet-Limb_Muscle-MUSCLE-30m-Mesenchymal-mesenchymal_stem_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FNDC1 HK2 RIPK1 MYCBP2 BMPER

8.35e-0619264511088878043a6ff95ba1970361256a82e434b80a
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GDA PDE1A SH3GL2 BMPER RYR2

8.35e-061926455c7e8b80b44d9ce55c797cdf8267ac5382e26cac
ToppCellFibroblast-B_(Myofibroblast)|World / shred on cell class and cell subclass (v4)

HHIP PDE1A FNDC1 CCN1 ITGA9

9.00e-06195645a8d6416518f226e1ec2d6bdc9d4b90cef5cb1365
ToppCellfacs-Lung-nan|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HHIP FNDC1 ASPH ITGA9 FKBP5

9.23e-06196645b05f77f3990b662682ffeaf0e4c2fb190e0a6e65
ToppCellfacs-Lung-nan-3m|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HHIP FNDC1 ASPH ITGA9 FKBP5

9.23e-06196645787c6cd92035e0b1108c2c086c42a229016e476b
ToppCellPND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

HHIP FNDC1 CCN1 FHOD3 ITGA9

9.46e-061976459d7a1c7dc70ba5e35645f19f9e056e4fa2494aa0
ToppCellwk_15-18-Mesenchymal-Myofibro_&_SMC-Late_airway_SMC|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

JUNB HHIP FNDC1 CCN1 ITGA9

9.69e-061986452d0c14f8cabab99bc6d7c27685437c78841c7245
ToppCell5'-GW_trimst-2-SmallIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HHIP PDE1A MYO1B BMPER ITGA9

9.69e-0619864509be07ebfc3e49c3858e9b74605b69cf4fc28b56
ToppCellTracheal-10x5prime-Stromal-Myofibroblastic-Muscle_smooth_airway_ASM|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

FNDC1 SPTB FKBP5 RYR2 CNTN1

9.69e-061986451e1ea54f0c234f3b6d29064c4881d8a0c0949a75
ToppCellTracheal-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_airway_ASM|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

FNDC1 FHOD3 IGSF9B RYR2 CNTN1

9.69e-0619864522e766df1276c5b14aa0d83f434f47140ebb98ea
ToppCellControl_saline-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast|Control_saline / Treatment groups by lineage, cell group, cell type

HHIP FNDC1 FHOD3 ITGA9 RYR2

1.02e-05200645c5e051f1aac8dda376c342a9932785a23450e073
ToppCellLPS_anti-TNF-Mesenchymal_myocytic|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

HHIP FNDC1 CCN1 MYO1B RYR2

1.02e-0520064567dcbd86fbc79fd585d0793f979e4aac100326c9
ToppCellfacs-Marrow-T-cells-3m-Myeloid-granulocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GDA SNX18 RAP1GAP2 CNTN1

6.13e-05148644b4632029ebd14969bda59a1bd1454eadb8efe563
ToppCellfacs-Marrow-T-cells-3m-Myeloid-granulocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GDA SNX18 RAP1GAP2 CNTN1

6.13e-05148644ba277c898678dd36f8dc1d681301c71901b89055
ToppCellChildren_(3_yrs)-Epithelial-basal_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

EPHA2 FHOD3 ITGA9 CNTN1

7.70e-051576446ee2692f705bdd93ba523dffaf2f0cd921b47e28
ToppCellPND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_prolif|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PDE1A FNDC1 CCN1 ITGA9

8.70e-051626443f264263878af630921911c2b344ac56eb1e7099
ToppCellChildren_(3_yrs)-Mesenchymal-airway_smooth_muscle_cell-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

FNDC1 CASQ1 IGSF9B BMPER

9.12e-05164644e3983f655cdba308fb192182829f17bef99ce0ba
ToppCellTCGA-Ovary-Primary_Tumor-Ovarian_Carcinoma-Serous_Cystadenocarcinoma-5|TCGA-Ovary / Sample_Type by Project: Shred V9

UTP25 NFATC3 CHD4 PUM1

9.56e-0516664432d2eaf8a5d03881bf74d680825af2d5110b082d
ToppCellBasal-basal-4|World / Class top

JUNB CCN1 ASPH CNTN1

9.56e-051666442721772eb2a9f45c5e9aaf4d73d198fea11a3586
ToppCellE16.5-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_prolif|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PTPN3 GDA FKBP5 ZFX

1.02e-04169644305cedbd97059029d7d2a248a8a4b6cfe281aa54
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L5_IT|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

PDE1A RAP1GAP2 IGSF9B BMPER

1.05e-0417064467415b098e8ba815b501e557192a9f2b10ee995a
ToppCellPND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

HHIP PDE1A CASQ1 FHOD3

1.07e-0417164482de2885c8ce4fb7776da6a0207b3355c0910121
ToppCellPND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC-ASMC_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

HHIP PDE1A CASQ1 FHOD3

1.07e-0417164409e653973962fb884878089d281f0947f7a285f6
ToppCellfacs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYT1 RAP1GAP2 ULK4 IGSF9B

1.15e-04174644f1fe1f4216748a9562dd03bd48c70b23c7ff4d1d
ToppCellBasal-basal-3|World / Class top

JUNB CCN1 EPHA2 CNTN1

1.17e-04175644a0d7ced5204a9efbbb91ac99410a088f8ed2df0f
ToppCellCOVID-19-kidney-Distal_Epi_Doublet_(PCT)|kidney / Disease (COVID-19 only), tissue and cell type

GDA PDE1A ULK4 RAB11FIP3

1.20e-0417664436f77d878a53b30465b0dea8333a3865dba75613
ToppCellAT1_cells-Donor_04|World / lung cells shred on cell class, cell subclass, sample id

CCN1 SH3GL2 MYO1B BMPER

1.22e-041776443128b8d04687acee1ac4190b2569d6328b98eaf3
ToppCell356C-Fibroblasts-Fibroblast-G|356C / Donor, Lineage, Cell class and subclass (all cells)

CCN1 BMPER RYR2 CNTN1

1.22e-041776448220cc2fc0ee8764a67a3be51d75248be2453040
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GDA PDE1A RAP1GAP2 BMPER

1.22e-041776444c069f0d044a96118090b85ca592a21d6b5d9399
ToppCell356C-Fibroblasts-Fibroblast-G-|356C / Donor, Lineage, Cell class and subclass (all cells)

CCN1 BMPER RYR2 CNTN1

1.22e-041776447617270f49cd6b7ba66db72d20560cee985012b2
ToppCellChildren_(3_yrs)-Mesenchymal-pericyte_cell-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

SPTB MYO1B BMPER RYR2

1.25e-04178644185b44700f06ec58b3c09c80520502166c965fd6
ToppCellcellseq2-Mesenchymal-Fibroblastic-Fibroblastic_2-ASMC|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

FNDC1 CIB2 IGSF9B RYR2

1.25e-041786448ec2a25dda96c9cc9c2904b6cb18f75a293f4969
ToppCellcellseq2-Mesenchymal-Fibroblastic-Fibroblastic_2|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

FNDC1 CIB2 IGSF9B RYR2

1.25e-041786446c91331196696e0cf239d105f458e3230659fa38
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PDE1A SH3GL2 MYO1B FHOD3

1.28e-04179644d3438fed0d85d5ed5afa8ff820c45143d77b6c0d
ToppCellRV|World / Chamber and Cluster_Paper

PDE1A FHOD3 BMPER ITGA9

1.33e-04181644bbe1e6e59d8889bd37d6e8303116cbdcafca7236
ToppCellControl-Epithelial-Basal|World / Disease state, Lineage and Cell class

PTPN3 CCN1 EPHA2 MYO1B

1.36e-04182644759390dde9b18757f7675d13d44c89d0e32f8d93
ToppCell3'-GW_trimst-2-LargeIntestine-Mesenchymal-myocytic|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

JUNB HHIP FNDC1 CCN1

1.36e-04182644728a2152c166551ac229370c0900fe2bc426ea9b
ToppCellwk_15-18-Mesenchymal-Myofibro_&_SMC-Early_airway_SMC_2|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

HHIP FNDC1 CASQ1 IGSF9B

1.39e-04183644a1d4f25e13f5b9e92a9ca0a804a7bed5df8fb2fe
ToppCellCOVID-19-Heart-CM_4|COVID-19 / Disease (COVID-19 only), tissue and cell type

SPTB FHOD3 ITGA9 RYR2

1.39e-041836442902b6e8aa9a6f62bc1a792c971ab7f651a8e676
ToppCellControl-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

HHIP FNDC1 ITGA9 RYR2

1.39e-041836447eae9b3b4d1c9b135fa7cff348393d4adec474b4
ToppCellPosterior_cortex-Neuronal-Excitatory|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

GDA SH3GL2 RAP1GAP2 RYR2

1.42e-0418464425ccf08a8a26d7e7827b6357f33a53aaf423577d
ToppCellLPS-antiTNF-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PTPN3 HHIP ASPH ITGA9

1.42e-04184644ab2f06906fc7a9931dfa0864ef506832b07fb93e
ToppCellControl-Epithelial_alveolar-AT_2-Differentiating_AT2|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PTPN3 HHIP ASPH ITGA9

1.45e-041856440d2add28ac1f4fa6de7699be009bf8391badaf4c
ToppCelldroplet-Liver-LIVER_HEP-30m-Mesenchymal|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HHIP PDE1A DYNC2LI1 CASQ1

1.45e-04185644f814ec9d4ade717a0109398e9768d0d66f09317b
ToppCelldroplet-Liver-LIVER_HEP-30m-Mesenchymal-hepatic_stellate_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HHIP PDE1A DYNC2LI1 CASQ1

1.45e-0418564440e958511790e84321da5ccf735f9974c06a0263
ToppCelldroplet-Liver-LIVER_HEP-30m-Mesenchymal-hepatic_stellate_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HHIP PDE1A DYNC2LI1 CASQ1

1.45e-041856445f2eeba80aff145e85cfd81e2890a155406badb9
ToppCell(00)_Basal-(4)_1wkpi|(00)_Basal / shred by cell type and Timepoint

JUNB CCN1 EPHA2 CNTN1

1.45e-04185644bf82ba905e5eee1c39a2731702071d3de10a78b8
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

GDA RAP1GAP2 IGSF9B RYR2

1.48e-0418664456c139e679d640ea901ead657a8e8887e0fca098
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PDE1A RAP1GAP2 FHOD3 FKBP5

1.48e-041866441850583d23903d08226aeb0edb3e07b0994330e4
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PDE1A RAP1GAP2 FHOD3 FKBP5

1.48e-041866444dafc215c42e7949f932a3627359c107943b5d6b
ToppCell3'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

JUNB HHIP PDE1A BMPER

1.48e-04186644d3509a579871ba6a8c4edd6137b28f271c9dbe70
ToppCell3'-GW_trimst-2-LargeIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

JUNB HHIP PDE1A CIB2

1.48e-041866448ea708070166c858cd9bd871670655b0114c32a5
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PTPN3 PDE1A SH3GL2 BMPER

1.51e-04187644f18628ffc7ff7c762b8339ba8822cf0c3157f469
ToppCellControl-Fibroblasts-Alveolar_FB|Control / group, cell type (main and fine annotations)

CCN1 ULK4 BMPER RYR2

1.51e-0418764492d468dde81125d51daf7abd4703741abe1ab91c
ToppCell3'-GW_trimst-2-LargeIntestine-Mesenchymal-myocytic-myofibroblast_(RSPO2+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

JUNB HHIP FNDC1 RAD21

1.51e-04187644173f029dcf32af008f517912f6d110a33a9e98cf
ToppCell18-Airway-Epithelial-Club-like_secretory|Airway / Age, Tissue, Lineage and Cell class

PTPN3 GDA EPHA2 RAB11FIP3

1.51e-04187644d1e301afcc39054ae1f867d80e564e30a137e3f8
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PTPN3 PDE1A SH3GL2 RYR2

1.54e-0418864450c1b1d690f0e9443082f2adf4f1b8e9ce4cd337
ToppCelldroplet-Tongue-nan|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PBRM1 HK2 PRPF38B CHD4

1.54e-04188644d62cc37e86b7b186e53aeb7f421c4e5ee28f23bd
ToppCellLPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

HHIP FNDC1 ITGA9 RYR2

1.54e-04188644293f2fa99f5f96aa7fd2b2a5cc94ff60eeaabe11
ToppCellFetal_29-31_weeks-Mesenchymal-airway_smooth_muscle_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

HHIP FNDC1 EOGT ITGA9

1.54e-041886444d1e5f85342ae550086609d7680e32730b78b5d2
ToppCellfacs-Brain_Non-Myeloid-Hippocampus_-18m-Macroglial-oligodendrocyte_precursor_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FNDC1 MYT1 ITGA9 CNTN1

1.54e-04188644006db2c2c44971ca9241c582bc89f258c785f5ed
ToppCellfacs-Brain_Non-Myeloid-Hippocampus_-18m-Macroglial-Oligodendrocyte_progenitor_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FNDC1 MYT1 ITGA9 CNTN1

1.54e-04188644d0e6fb4a3b3d79d3512b5500062ea285495ae526
ToppCellfacs-Skin-nan-18m-Mesenchymal-nan|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDE1A FNDC1 ITGA9 SP110

1.57e-0418964429287525120be2953b76881ba3cfc4379c265e7a
ToppCellfacs-Skin-nan-18m-Mesenchymal-fibroblast|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDE1A FNDC1 ITGA9 SP110

1.57e-041896447150dad9a92a715487c2d8130fa01b752ea69663
ToppCellfacs-Skin-nan-18m-Mesenchymal|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDE1A FNDC1 ITGA9 SP110

1.57e-041896446e4c0effd5192fd00052abc048fdb87a74fb6554
ToppCelldroplet-Heart-HEART_(ALL_MINUS_AORTA)-30m|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

JUNB GDA HK2 CCN1

1.57e-04189644562f8bf5a7d38afb4a8f2415d617d5f79cfb7e3f
ToppCellHippocampus-Neuronal-Excitatory|Hippocampus / BrainAtlas - Mouse McCarroll V32

GDA PDE1A SH3GL2 RAP1GAP2

1.57e-041896444b90d181eb0a42814eeb23bc82e52fd3a12392a7
ToppCelldroplet-Heart-HEART_(ALL_MINUS_AORTA)|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

JUNB GDA HK2 CCN1

1.57e-04189644270dd4a0fc5260288fe6829837942c78b40ecec4
ToppCellControl-Stromal_mesenchymal-Lung_smooth_muscle|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

HHIP FNDC1 ITGA9 RYR2

1.57e-0418964445e588b2a4ad9e3ff74e22d9d627ed3571f3b8b8
ToppCellCOPD-Myeloid-ncMonocyte|World / Disease state, Lineage and Cell class

SNX18 RAP1GAP2 FKBP5 HEATR3

1.61e-04190644aece860b5609ad5a8fc920d685f0d0ec71bf9018
ToppCellCOPD-Myeloid-ncMonocyte|Myeloid / Disease state, Lineage and Cell class

SNX18 RAP1GAP2 FKBP5 HEATR3

1.61e-04190644ed978cd5d9da87b49878a330e362762c487f849f
ToppCellPND10|World / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PBRM1 MYCBP2 CHD4 ITGA9

1.61e-04190644d67e2814047c8df2ae4b7bc8be9539f5df6ecef2
ToppCellfacs-Lung-nan-3m-Mesenchymal-pulmonary_interstitial_fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HHIP PDE1A FHOD3 ITGA9

1.61e-04190644c7bd087f36321cec61b98657433b4d19d135791f
ToppCellfacs-Brain_Non-Myeloid-Cortex-3m-Macroglial-oligodendrocyte_precursor_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYT1 IGSF9B ITGA9 CNTN1

1.61e-041906449b825b2586c7b173ff27fcf2abc5860faf50984a
ToppCellfacs-Lung-nan-3m-Mesenchymal-Myofibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HHIP PDE1A FHOD3 ITGA9

1.61e-04190644834218fcc59df5e7e52de154272f3d55d81d0dac
ToppCellfacs-Brain_Non-Myeloid-Cortex-3m-Macroglial-Oligodendrocyte_progenitor_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYT1 IGSF9B ITGA9 CNTN1

1.61e-04190644d146af1926474328a7c822bc140c4dda66e1bbfb
ToppCellFetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

EOGT CLIP2 BMPER RYR2

1.64e-0419164408720998aa55131d7377c4c67c4c935865bd7d79
ToppCelldroplet-Heart-HEART_(LV+RV_ONLY)-30m-Mesenchymal|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDE1A FNDC1 SNX18 BMPER

1.64e-041916441efb47743b6834b64cb0f61721ddbe875b1a66ca
ToppCelldroplet-Heart-HEART_(LV+RV_ONLY)-30m-Mesenchymal-fibroblast_of_cardiac_tissue|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDE1A FNDC1 SNX18 BMPER

1.67e-041926445e6f8206ee0b10cdba79a7c4a05452cb025a5512
ToppCellControl-Epithelial-Club|Control / Disease state, Lineage and Cell class

CCN1 EPHA2 MYO1B ITGA9

1.67e-04192644d84ed1ea4a03edaa18c804f75afb03bd7b1f0e16
ToppCelldroplet-Pancreas-Endocrine-18m|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

JUNB RAP1GAP2 SDF4 FKBP5

1.67e-041926444510aa262da8dcf7c944b3907a51aba5a9397a4e
ToppCelldroplet-Heart-HEART_(LV+RV_ONLY)-30m-Mesenchymal-fibroblast|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDE1A FNDC1 SNX18 BMPER

1.67e-04192644136af0186c70c14c5f2b33ed7a148156de5b478c
ToppCellrenal_cortex_nuclei|World / Celltypes from Cells and Nuclei per compartment and clinical group

RBM6 FHOD3 FKBP5 RAB11FIP3

1.67e-04192644e8cc4d08fcfceeab75a02558817e4ccd7dbafe3a
ToppCellCOPD-Stromal-Myofibroblast|Stromal / Disease state, Lineage and Cell class

PDE1A CCN1 ULK4 RYR2

1.67e-0419264462904f94dfce430456f05066522cbf9bd29f4d7e
DrugConvolamine hydrochloride [500-56-1]; Up 200; 11.8uM; MCF7; HT_HG-U133A

EOGT ASPH WDR55 SDF4 THAP9 RYR2 RAB11FIP3

1.21e-061916572771_UP
DrugPancuronium bromide [15500-66-0]; Down 200; 5.4uM; MCF7; HT_HG-U133A

ARNT NFATC3 DYNC2LI1 MYO1B PUM1 FKBP5 ZFX

1.39e-061956574393_DN
DrugGalanthamine hydrobromide [1953-04-4]; Down 200; 10.8uM; MCF7; HT_HG-U133A

JUNB ERLIN2 ASPH PUM1 HEATR3 ZFX

1.93e-051946564772_DN
DrugNystatine [1400-61-9]; Up 200; 4.4uM; HL60; HT_HG-U133A

JUNB USP5 SPTB THAP9 ZFX RAB11FIP3

1.98e-051956562500_UP
DrugSulfadiazine [68-35-9]; Up 200; 16uM; HL60; HT_HG-U133A

ARNT EOGT UTP25 DYNC2LI1 HTATSF1 CHD4

2.04e-051966561852_UP
DrugChlormezanone [80-77-3]; Down 200; 14.6uM; MCF7; HT_HG-U133A

JUNB USP5 CCN1 NFATC3 EPHA2 ZFX

2.10e-051976565697_DN
DrugVinpocetine [42971-09-5]; Down 200; 11.4uM; PC3; HT_HG-U133A

JUNB ARNT DYNC2LI1 ASPH CHD4 SP110

2.22e-051996565859_DN
DrugTropicamide [1508-75-4]; Down 200; 14uM; HL60; HT_HG-U133A

JUNB USP5 EOGT NFATC3 ASPH ZFX

2.22e-051996562347_DN
DiseaseSchizoaffective disorder-bipolar type

MYT1 RAD21

5.28e-0416632EFO_0009965
DiseaseParkinson disease

MYCBP2 WBP1L SH3GL2 IGSF9B CNTN1

6.19e-04321635MONDO_0005180
Diseasepulse pressure measurement

PDE1A FNDC1 PBRM1 CCN1 MYT1 WBP1L WDR55 ULK4 FHOD3 ITGA9

6.90e-0413926310EFO_0005763
DiseasePsychotic Disorders

PBRM1 PVALB FKBP5

1.33e-03101633C0033975
DiseaseCholangiocarcinoma

PTPN3 PBRM1

1.41e-0326632C0206698
DiseaseDrug-Induced Liver Disease

USP5 GDA ARNT SNX18 PUM1

1.72e-03404635C0860207
DiseaseDrug-Induced Acute Liver Injury

USP5 GDA ARNT SNX18 PUM1

1.72e-03404635C3658290
DiseaseChemical and Drug Induced Liver Injury

USP5 GDA ARNT SNX18 PUM1

1.72e-03404635C4277682
DiseaseHepatitis, Drug-Induced

USP5 GDA ARNT SNX18 PUM1

1.72e-03404635C1262760
DiseaseHepatitis, Toxic

USP5 GDA ARNT SNX18 PUM1

1.72e-03404635C0019193
DiseaseChemically-Induced Liver Toxicity

USP5 GDA ARNT SNX18 PUM1

1.72e-03404635C4279912
Diseaseosteoarthritis, hip, body mass index

HHIP FKBP5

1.88e-0330632EFO_0004340, EFO_1000786
Diseasetriacylglycerol 54:3 measurement

CLIP2 MPHOSPH10

2.00e-0331632EFO_0010421

Protein segments in the cluster

PeptideGeneStartEntry
DSDTEGFLLGEVKGE

ABRAXAS1

26

Q6UWZ7
GLDFDDDGEGNSKFL

ARNT

46

P27540
DRFKEDFFQSGEIGG

EOGT

171

Q5NDL2
VFLGKDLGGFDEDAE

SDF4

81

Q9BRK5
DGLLGKELGFDASEV

CCN1

176

O00622
PKAAEVGDDFLGDFV

CLIP2

66

Q9UDT6
EEVLGKLGIYDADGD

ASPH

81

Q12797
KLGIYDADGDGDFDV

ASPH

86

Q12797
KGGEADNLDEFLKEF

RAD21

406

O60216
FDALDGDGDGFVRIE

RAB11FIP3

211

O75154
DEDGKFGFNLKGGVD

PTPN3

516

P26045
DFKGEDLFEDGGIIR

FKBP5

136

Q13451
LLEAKFAELEGGDDD

PBRM1

1311

Q86U86
GSEGDGAEIAEKFVF

DYNC2LI1

21

Q8TCX1
DGTEKGDFLALDLGG

HK2

521

P52789
EEFFLQGDKEAELGL

PDE1A

386

P54750
DSDEDEGGLFGSKKL

MPHOSPH10

241

O00566
FEGLADKLSFGLEDE

ERLIN2

316

O94905
FDGDKLGDLKEEGDV

PUM1

261

Q14671
KLFDDSDERGTLGGF

HTATSF1

716

O43719
DVAIGAPKEDDFAGA

ITGA9

381

Q13797
GEALDALFDVFADGK

HEATR3

601

Q7Z4Q2
DGAGDLLPDKELGFE

BSND

301

Q8WZ55
DDLIGGDGNFKFDVD

BMPER

506

Q8N8U9
EEEDAGFFKGGKEDL

FNDC1

1181

Q4ZHG4
GKEVVLLDFAAAGGE

EPHA2

26

P29317
DKGVGFGLVDSEKDA

CASQ1

101

P31415
GVSEEDKGFGPIFEE

CNTN1

31

Q12860
DELEGFQDDAGRGKK

FHOD3

81

Q2V2M9
GLDGEIGNFEVGKEF

GDA

381

Q9Y2T3
FGTEELFKDEATDGG

CHD4

1221

Q14839
SGSELAFKDFDVGDG

RYR2

1186

Q92736
AEGGATKGKEIDFDD

KIF2C

46

Q99661
KFGVGDDDDFRDQGL

UTP25

336

Q68CQ4
DAGLFKEEGGLDFLG

RBM6

381

P78332
EEDKFENGGHGGFLE

RAP1GAP2

481

Q684P5
GDVKFVLDSAFLEGG

PRORSD1P

116

A6NEY8
GFDEESAILGAGREF

MYCBP2

526

O75592
FGQVGLDLEAEFEKD

SP110

656

Q9HB58
DFLESAELDSGGFGK

RIPK1

16

Q13546
LGFFEGDAKFGERNE

HHIP

16

Q96QV1
DIAAKFGGLAAGEDN

AGPS

486

O00116
ADLDGDGKLGFADFE

CIB2

156

O75838
LAGGFADEVDRGDEF

UHRF2

491

Q96PU4
VGGAEGTKLDDDFKE

SH3GL1

21

Q99961
GFMDFGLGKLDADET

THAP9

301

Q9H5L6
SFDLGEDGGLKVDDH

PYROXD1

331

Q8WU10
DDGIPGTEGEFFAKD

IGSF9B

661

Q9UPX0
VGGAEGTKLDDDFKE

SH3GL2

21

Q99962
FEPENEGELGFKEGD

SH3GL2

301

Q99962
EAFVLGEASGFVKDG

SNX18

241

Q96RF0
SGFIEEDELGFILKG

PVALB

56

P20472
EDELGFILKGFSPDA

PVALB

61

P20472
FLDDEEDLDVKAGGG

PRPF38B

181

Q5VTL8
EELFEKGEQLLGAGE

NISCH

131

Q9Y2I1
ELDFKLVFGEDGAPA

NFATC3

11

Q12968
FSGGKGLFDDEDEES

WASHC2C

361

Q9Y4E1
DIFGDEEGDLFKEKA

WASHC2C

481

Q9Y4E1
GEEGGDADLSIEKRF

SPTB

1446

P11277
FSGGKGLFDDEDEES

WASHC2A

361

Q641Q2
DIFGDEEGDLFKEKA

WASHC2A

481

Q641Q2
AAEEEDGEFLGMKGF

YIPF3

71

Q9GZM5
DLLAAGDVDGDVFVF

WDR55

51

Q9H6Y2
FKADPGEDDLGGTVD

ZFX

256

P17010
AGLGELDPGAFLDKD

WBP1L

201

Q9NX94
IGVEGGFDLSEEKFE

USP5

101

P45974
EEFFALVAAEEGGGD

ULK4

151

Q96C45
EQEGFADGFVKALDD

JUNB

131

P17275
DIEFDFKGDPLGGVI

MYO1B

171

O43795
AAEGAASEEGEKGLF

MYT1

201

Q01538