Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
HumanPheno	Buphthalmos	FZD4 LTBP2 SBF2	2.13e-05	27	11	3	HP:0000557
HumanPheno	Abnormally large globe	FZD4 LTBP2 SBF2	1.01e-04	45	11	3	HP:0001090
Domain	Ig_I-set	NCAM2 LINGO3 SPEG	4.52e-03	190	33	3	IPR013098
Domain	I-set	NCAM2 LINGO3 SPEG	4.52e-03	190	33	3	PF07679
Domain	LRR	PIDD1 LINGO3 STK11IP	5.28e-03	201	33	3	PS51450
Domain	IGc2	NCAM2 LINGO3 SPEG	8.12e-03	235	33	3	SM00408
Domain	Ig_sub2	NCAM2 LINGO3 SPEG	8.12e-03	235	33	3	IPR003598
Domain	Leu-rich_rpt	PIDD1 LINGO3 STK11IP	1.20e-02	271	33	3	IPR001611
Pubmed	The intracellular II-III loops of Cav1.2 and Cav1.3 uncouple L-type voltage-gated Ca2+ channels from glucagon-like peptide-1 potentiation of insulin secretion in INS-1 cells via displacement from lipid rafts.	CACNA1C GCG	3.30e-06	3	37	2	19351867
Pubmed	Expression patterns of Wnts, Frizzleds, sFRPs, and misexpression in transgenic mice suggesting a role for Wnts in pancreas and foregut pattern formation.	FZD4 GCG ISL1	7.72e-06	36	37	3	12412008
Pubmed	Independent requirement for ISL1 in formation of pancreatic mesenchyme and islet cells.	GCG ISL1	1.10e-05	5	37	2	9000074
Pubmed	14-3-3 proteins sequester a pool of soluble TRIM32 ubiquitin ligase to repress autoubiquitylation and cytoplasmic body formation.	GIGYF1 MYCBP2 SPEG	1.24e-05	42	37	3	23444366
Pubmed	Using brain cell-type-specific protein interactomes to interpret neurodevelopmental genetic signals in schizophrenia.	CACNA1C ISL1 INA	1.63e-05	46	37	3	37207277
Pubmed	Aquaporin-9 is expressed in a mucus-secreting goblet cell subset in the small intestine.	GCG ISL1	1.65e-05	6	37	2	12681500
Pubmed	The islet-expressed Lhx1 transcription factor interacts with Islet-1 and contributes to glucose homeostasis.	GCG ISL1	2.30e-05	7	37	2	30620636
Pubmed	SSBP3 Interacts With Islet-1 and Ldb1 to Impact Pancreatic β-Cell Target Genes.	GCG ISL1	2.30e-05	7	37	2	26495868
Pubmed	Islet-1 regulates Arx transcription during pancreatic islet alpha-cell development.	GCG ISL1	2.30e-05	7	37	2	21388963
Pubmed	Activin receptor patterning of foregut organogenesis.	GCG ISL1	3.07e-05	8	37	2	10921901
Pubmed	p27 Regulates the transition of beta-cells from quiescence to proliferation.	GCG ISL1	3.07e-05	8	37	2	17065330
Pubmed	Fgf10 is essential for maintaining the proliferative capacity of epithelial progenitor cells during early pancreatic organogenesis.	GCG ISL1	3.07e-05	8	37	2	11748146
Pubmed	Phenotypic analysis of mice carrying human-type MAFB p.Leu239Pro mutation.	GCG ISL1	3.07e-05	8	37	2	31882119
Pubmed	p57 and Hes1 coordinate cell cycle exit with self-renewal of pancreatic progenitors.	GCG ISL1	4.93e-05	10	37	2	16899237
Pubmed	Analysis of pancreatic endocrine development in GDF11-deficient mice.	GCG ISL1	4.93e-05	10	37	2	16964608
Pubmed	Developmental expression of metalloproteases ADAM 9, 10, and 17 becomes restricted to divergent pancreatic compartments.	GCG ISL1	6.02e-05	11	37	2	15739225
Pubmed	Hey2 functions in parallel with Hes1 and Hes5 for mammalian auditory sensory organ development.	ISL1 OC90	6.02e-05	11	37	2	18302773
Pubmed	Osteocalcin promotes β-cell proliferation during development and adulthood through Gprc6a.	GCG ISL1	6.02e-05	11	37	2	24009262
Pubmed	Expression of HNF-4alpha (MODY1), HNF-1beta (MODY5), and HNF-1alpha (MODY3) proteins in the developing mouse pancreas.	GCG ISL1	6.02e-05	11	37	2	17996499
Pubmed	Dorsal pancreas agenesis in retinoic acid-deficient Raldh2 mutant mice.	GCG ISL1	6.02e-05	11	37	2	16026781
Pubmed	Ghrelin is a novel target of Pax4 in endocrine progenitors of the pancreas and duodenum.	GCG ISL1	6.02e-05	11	37	2	18058910
Pubmed	Abrogation of protein convertase 2 activity results in delayed islet cell differentiation and maturation, increased alpha-cell proliferation, and islet neogenesis.	GCG ISL1	7.22e-05	12	37	2	12933680
Pubmed	Notch/Rbp-j signaling prevents premature endocrine and ductal cell differentiation in the pancreas.	GCG ISL1	7.22e-05	12	37	2	16399505
Pubmed	Lack of TCF2/vHNF1 in mice leads to pancreas agenesis.	GCG ISL1	7.22e-05	12	37	2	15668393
Pubmed	Attenuated Wnt signaling perturbs pancreatic growth but not pancreatic function.	GCG ISL1	7.22e-05	12	37	2	16186384
Pubmed	The role of Brn4/Pou3f4 and Pax6 in forming the pancreatic glucagon cell identity.	GCG ISL1	7.22e-05	12	37	2	15031110
Pubmed	Selective agenesis of the dorsal pancreas in mice lacking homeobox gene Hlxb9.	GCG ISL1	7.22e-05	12	37	2	10471501
Pubmed	MafA and MafB regulate genes critical to beta-cells in a unique temporal manner.	GCG ISL1	7.22e-05	12	37	2	20627934
Pubmed	Postnatal expansion of the pancreatic beta-cell mass is dependent on survivin.	GCG ISL1	8.53e-05	13	37	2	18599523
Pubmed	Pax6 is regulated by Meis and Pbx homeoproteins during pancreatic development.	GCG ISL1	8.53e-05	13	37	2	17049510
Pubmed	Microphthalmia transcription factor regulates pancreatic β-cell function.	GCG ISL1	8.53e-05	13	37	2	23610061
Pubmed	Expression profile of MODY3/HNF-1alpha protein in the developing mouse pancreas.	GCG ISL1	8.53e-05	13	37	2	12189445
Pubmed	Generation of cerebellar neuron precursors from embryonic stem cells.	NCAM2 ISL1	8.53e-05	13	37	2	16406324
Pubmed	neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas.	GCG ISL1	8.53e-05	13	37	2	10677506
Pubmed	PPARβ/δ affects pancreatic β cell mass and insulin secretion in mice.	GCG ISL1	9.94e-05	14	37	2	23093780
Pubmed	Hex homeobox gene-dependent tissue positioning is required for organogenesis of the ventral pancreas.	GCG ISL1	9.94e-05	14	37	2	14736744
Pubmed	The concerted activities of Pax4 and Nkx2.2 are essential to initiate pancreatic beta-cell differentiation.	GCG ISL1	9.94e-05	14	37	2	14729487
Pubmed	Homeobox gene Nkx6.1 lies downstream of Nkx2.2 in the major pathway of beta-cell formation in the pancreas.	GCG ISL1	1.15e-04	15	37	2	11076772
Pubmed	Snail2, a mediator of epithelial-mesenchymal transitions, expressed in progenitor cells of the developing endocrine pancreas.	GCG ISL1	1.15e-04	15	37	2	17185046
Pubmed	Combined activities of hedgehog signaling inhibitors regulate pancreas development.	GCG ISL1	1.15e-04	15	37	2	12917290
Pubmed	Persistent expression of Hlxb9 in the pancreatic epithelium impairs pancreatic development.	GCG ISL1	1.15e-04	15	37	2	11784060
Pubmed	Formation of retinal direction-selective circuitry initiated by starburst amacrine cell homotypic contact.	ISL1 INA	1.15e-04	15	37	2	29611808
Pubmed	Dynamic regulation of Pdx1 enhancers by Foxa1 and Foxa2 is essential for pancreas development.	GCG ISL1	1.31e-04	16	37	2	19141476
Pubmed	The IIIb isoform of fibroblast growth factor receptor 2 is required for proper growth and branching of pancreatic ductal epithelium but not for differentiation of exocrine or endocrine cells.	GCG ISL1	1.31e-04	16	37	2	12559489
Pubmed	The bHLH protein PTF1-p48 is essential for the formation of the exocrine and the correct spatial organization of the endocrine pancreas.	GCG ISL1	1.31e-04	16	37	2	9851981
Pubmed	Cloning and analysis of Nkx6.3 during CNS and gastrointestinal development.	GCG ISL1	1.31e-04	16	37	2	16326147
Pubmed	Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells.	GCG ISL1	1.31e-04	16	37	2	9584121
Pubmed	Independent development of pancreatic alpha- and beta-cells from neurogenin3-expressing precursors: a role for the notch pathway in repression of premature differentiation.	GCG ISL1	1.31e-04	16	37	2	10868931
Pubmed	SOX9 is required for maintenance of the pancreatic progenitor cell pool.	GCG ISL1	1.31e-04	16	37	2	17267606
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	ENDOG MYCBP2 STK11IP ARHGAP21 SPEG MYORG SBF2	1.43e-04	1105	37	7	35748872
Pubmed	Fbxo45 forms a novel ubiquitin ligase complex and is required for neuronal development.	ISL1 MYCBP2	1.48e-04	17	37	2	19398581
Pubmed	N-cadherin is dispensable for pancreas development but required for beta-cell granule turnover.	GCG ISL1	1.48e-04	17	37	2	20533404
Pubmed	RBM4 promotes pancreas cell differentiation and insulin expression.	GCG ISL1	1.48e-04	17	37	2	23129807
Pubmed	Fgf10 maintains notch activation, stimulates proliferation, and blocks differentiation of pancreatic epithelial cells.	GCG ISL1	1.48e-04	17	37	2	14517990
Pubmed	Notch signalling controls pancreatic cell differentiation.	GCG ISL1	1.48e-04	17	37	2	10476967
Pubmed	Inhibition of stearoyl-CoA desaturase 1 in the mouse impairs pancreatic islet morphogenesis and promotes loss of β-cell identity and α-cell expansion in the mature pancreas.	GCG ISL1	1.48e-04	17	37	2	36529318
Pubmed	Loss of Myt1 function partially compromises endocrine islet cell differentiation and pancreatic physiological function in the mouse.	GCG ISL1	1.48e-04	17	37	2	17928203
Pubmed	Analysis of mPygo2 mutant mice suggests a requirement for mesenchymal Wnt signaling in pancreatic growth and differentiation.	GCG ISL1	1.48e-04	17	37	2	18452912
Pubmed	Cdc42/N-WASP signaling links actin dynamics to pancreatic β cell delamination and differentiation.	GCG ISL1	1.48e-04	17	37	2	24449844
Pubmed	Pbx1 inactivation disrupts pancreas development and in Ipf1-deficient mice promotes diabetes mellitus.	GCG ISL1	1.67e-04	18	37	2	11912494
Pubmed	Expression of Ins1 and Ins2 genes in mouse fetal liver.	GCG ISL1	1.67e-04	18	37	2	24258027
Pubmed	Transcription factor hepatocyte nuclear factor 6 regulates pancreatic endocrine cell differentiation and controls expression of the proendocrine gene ngn3.	GCG ISL1	1.67e-04	18	37	2	10825208
Pubmed	Signals from the neural crest regulate beta-cell mass in the pancreas.	GCG ISL1	1.67e-04	18	37	2	18506029
Pubmed	A dosage-dependent requirement for Sox9 in pancreatic endocrine cell formation.	GCG ISL1	1.67e-04	18	37	2	18723011
Pubmed	Global deficits in development, function, and gene expression in the endocrine pancreas in a deletion mouse model of Prader-Willi syndrome.	GCG ISL1	1.67e-04	18	37	2	21343540
Pubmed	Expression of neurogenin3 reveals an islet cell precursor population in the pancreas.	GCG ISL1	1.67e-04	18	37	2	10903178
Pubmed	The transcription factors Nkx6.1 and Nkx6.2 possess equivalent activities in promoting beta-cell fate specification in Pdx1+ pancreatic progenitor cells.	GCG ISL1	1.67e-04	18	37	2	17537793
Pubmed	MafB is required for islet beta cell maturation.	GCG ISL1	1.67e-04	18	37	2	17360442
Pubmed	Conditional deletion of Men1 in the pancreatic β-cell leads to glucagon-expressing tumor development.	GCG ISL1	1.67e-04	18	37	2	25343275
Pubmed	NEUROD1 Is Required for the Early α and β Endocrine Differentiation in the Pancreas.	GCG ISL1	1.86e-04	19	37	2	34201511
Pubmed	Beta-cell β1 integrin deficiency affects in utero development of islet growth and vascularization.	GCG ISL1	1.86e-04	19	37	2	32060653
Pubmed	Pancreas-specific deletion of mouse Gata4 and Gata6 causes pancreatic agenesis.	GCG ISL1	1.86e-04	19	37	2	23006325
Pubmed	Genetic evidence of the programming of beta cell mass and function by glucocorticoids in mice.	GCG ISL1	2.07e-04	20	37	2	20857084
Pubmed	The Cdk4-E2f1 pathway regulates early pancreas development by targeting Pdx1+ progenitors and Ngn3+ endocrine precursors.	GCG ISL1	2.07e-04	20	37	2	21490060
Pubmed	Tbx1 coordinates addition of posterior second heart field progenitor cells to the arterial and venous poles of the heart.	LTBP2 ISL1	2.07e-04	20	37	2	25190705
Pubmed	NEUROD1 reinforces endocrine cell fate acquisition in pancreatic development.	GCG ISL1	2.07e-04	20	37	2	37689751
Pubmed	Islet-1 is required for the maturation, proliferation, and survival of the endocrine pancreas.	GCG ISL1	2.28e-04	21	37	2	19502415
Pubmed	NKX6 transcription factor activity is required for alpha- and beta-cell development in the pancreas.	GCG ISL1	2.28e-04	21	37	2	15944193
Pubmed	Conversion of biliary system to pancreatic tissue in Hes1-deficient mice.	GCG ISL1	2.28e-04	21	37	2	14702043
Pubmed	Lineage dynamics of murine pancreatic development at single-cell resolution.	GCG ISL1	2.51e-04	22	37	2	30254276
Pubmed	Growth-limiting role of endothelial cells in endoderm development.	GCG ISL1	2.51e-04	22	37	2	21281624
Pubmed	Arx is required for normal enteroendocrine cell development in mice and humans.	GCG ISL1	2.51e-04	22	37	2	22387004
Pubmed	Spleen versus pancreas: strict control of organ interrelationship revealed by analyses of Bapx1-/- mice.	GCG ISL1	2.51e-04	22	37	2	16912273
Pubmed	ISL1 controls pancreatic alpha cell fate and beta cell maturation.	GCG ISL1	2.51e-04	22	37	2	36899442
Pubmed	Gene regulation logic in retinal ganglion cell development: Isl1 defines a critical branch distinct from but overlapping with Pou4f2.	ISL1 INA	2.51e-04	22	37	2	18460603
Pubmed	Genetic evidence that Nkx2.2 acts primarily downstream of Neurog3 in pancreatic endocrine lineage development.	GCG ISL1	2.75e-04	23	37	2	28071588
Pubmed	The Krüppel-like zinc finger protein GLIS3 transactivates neurogenin 3 for proper fetal pancreatic islet differentiation in mice.	GCG ISL1	3.25e-04	25	37	2	21786021
Pubmed	Two transcription factors, Pou4f2 and Isl1, are sufficient to specify the retinal ganglion cell fate.	ISL1 INA	3.25e-04	25	37	2	25775587
Pubmed	Tshz1 Regulates Pancreatic β-Cell Maturation.	GCG ISL1	3.25e-04	25	37	2	25918232
Pubmed	A Specialized Niche in the Pancreatic Microenvironment Promotes Endocrine Differentiation.	GCG ISL1	3.52e-04	26	37	2	32857951
Pubmed	No death without life: vital functions of apoptotic effectors.	PIDD1 ENDOG	3.52e-04	26	37	2	18309324
Pubmed	The RNA helicase DDX6 controls early mouse embryogenesis by repressing aberrant inhibition of BMP signaling through miRNA-mediated gene silencing.	FZD4 ISL1	3.80e-04	27	37	2	36197846
Pubmed	Retinol Dehydrogenase-10 Regulates Pancreas Organogenesis and Endocrine Cell Differentiation via Paracrine Retinoic Acid Signaling.	GCG ISL1	4.09e-04	28	37	2	27740873
Pubmed	CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.	SORT1 HSPBP1 MYCBP2 STK11IP ARHGAP21	4.34e-04	606	37	5	36538041
Pubmed	MFng is dispensable for mouse pancreas development and function.	GCG ISL1	4.70e-04	30	37	2	19223466
Pubmed	Threshold-Dependent Cooperativity of Pdx1 and Oc1 in Pancreatic Progenitors Establishes Competency for Endocrine Differentiation and β-Cell Function.	GCG ISL1	5.35e-04	32	37	2	27292642
Pubmed	Normal Molecular Specification and Neurodegenerative Disease-Like Death of Spinal Neurons Lacking the SNARE-Associated Synaptic Protein Munc18-1.	CACNA1C ISL1	5.35e-04	32	37	2	26758845
Pubmed	The zinc-finger factor Insm1 (IA-1) is essential for the development of pancreatic beta cells and intestinal endocrine cells.	GCG ISL1	5.69e-04	33	37	2	16951258
Pubmed	Convergence of the insulin and serotonin programs in the pancreatic β-cell.	GCG ISL1	6.05e-04	34	37	2	22013016
Pubmed	Control of endodermal endocrine development by Hes-1.	GCG ISL1	6.05e-04	34	37	2	10615124
Cytoband	2q35	STK11IP SPEG	1.87e-03	79	37	2	2q35
Cytoband	11p15.5	PIDD1 DRD4	4.11e-03	118	37	2	11p15.5
Cytoband	Ensembl 112 genes in cytogenetic band chr2q35	STK11IP SPEG	4.89e-03	129	37	2	chr2q35
GeneFamily	TALE class homeoboxes and pseudogenes	MEIS3P1 MEIS3P2	3.35e-04	26	19	2	526
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	NCAM2 LINGO3 SPEG	6.05e-04	161	19	3	593
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	ARHGAP21 SBF2	1.94e-02	206	19	2	682
CoexpressionAtlas	gudmap_RNAseq_e11.5_Ureteric_stalks_2500_K0	SORT1 FZD4 HSPBP1 RAB11FIP4 ENDOG STK11IP GFER SPEG MYORG AMDHD2	2.71e-05	1275	35	10	gudmap_RNAseq_e11.5_Ureteric_stalks_2500_K0
ToppCell	3'-Child04-06-SmallIntestine-Epithelial-neuro-epithelial-L_cells_(PYY+)\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GCG ISL1 DRD4 INA	9.83e-06	167	36	4	5accd0bc7c95089feb2c09376d12cd8bd3773775
ToppCell	facs-Heart-LV-24m-Mesenchymal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LINGO3 GCG ISL1 INA	1.16e-05	174	36	4	f0974f4e94a9719f9b96820e70c23b6c6c0f02fe
ToppCell	saliva-Mild-Moderate_progression_d12-25-Myeloid-Macrophage-macrophage,_alveolar-Macro_c6-VCAN\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	OS9 LINGO3 MYCBP2 SBF2	1.38e-05	182	36	4	d486b0213bd3cf20965cb4e38e95981c4aaff259
ToppCell	Adult-Mesenchymal-matrix_fibroblast_1_cell-D175\|Adult / Lineage, Cell type, age group and donor	CACNA1C NCAM2 GCG LTBP2	1.53e-05	187	36	4	e15d2967aac248da3517bc2c7d1beaa1d5a0aa7f
ToppCell	10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte-D\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SORT1 RAB11FIP4 ARHGAP21 SH3BP5	1.74e-05	193	36	4	947200ef6c3a2e35ad7e6b4af29d92384bdf73f5
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-2M-Neuronal-ventral_progenitors_and_neurons_1\|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.	ISL1 INA MYCBP2 SH3BP5	1.88e-05	197	36	4	4961f66606f08e399508fd6cabca588e7ab406a8
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-Deep_Layer\|World / Primary Cells by Cluster	NCAM2 INA SH3BP5 SPINK5	1.88e-05	197	36	4	41e823b14697827f657b13adb3afa581bd91a9cb
ToppCell	facs-Lung-EPCAM-24m-Endothelial-Capillary_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GCG LTBP2 ISL1	3.70e-05	80	36	3	6720438bf51831e98402a700dfc25bd57e0c6798
ToppCell	390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_4\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	FZD4 NCAM2 SBF2	1.72e-04	134	36	3	72d7eec3aeb43319f3ef81bb5518fae8d8880136
ToppCell	356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0.5\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	TTC34 SPEG SBF2	2.30e-04	148	36	3	065177aaa63c0441d312260b43ecdac78c84ad03
ToppCell	droplet-Liver-Npc-21m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF346 CD5L ARHGAP21	2.63e-04	155	36	3	5d600e159738231d0607ea1a1ebd8510fc241b36
ToppCell	Adult-Mesenchymal-myofibroblast_cell-D122\|Adult / Lineage, Cell type, age group and donor	CACNA1C LTBP2 ENDOG	2.79e-04	158	36	3	410fa08c9d880d27e80ec939fa5ba5a41dcb31ab
ToppCell	Adult-Mesenchymal-airway_smooth_muscle_cell-D122\|Adult / Lineage, Cell type, age group and donor	CACNA1C LTBP2 SPEG	2.94e-04	161	36	3	64891f6f2ee1693c8481e951b9346e2f92d602e3
ToppCell	Fetal_29-31_weeks-Mesenchymal-vascular_smooth_muscle_cell-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CACNA1C LTBP2 SPEG	3.05e-04	163	36	3	51dee6c21cbeca4e17d1cc386e203f0c403089e8
ToppCell	facs-Heart-LV-24m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GCG ISL1 INA	3.05e-04	163	36	3	648d5439811b64412bc4678646f216105b90b9a1
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW16-Neuronal-GABAergic_neurons\|GW16 / Sample Type, Dataset, Time_group, and Cell type.	LINGO3 INA MYCBP2	3.11e-04	164	36	3	4d7b2d0980fb4f47721fa2891151e2bd892ccb91
ToppCell	Children_(3_yrs)-Mesenchymal-airway_smooth_muscle_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CACNA1C LTBP2 SPEG	3.11e-04	164	36	3	e3983f655cdba308fb192182829f17bef99ce0ba
ToppCell	3'-GW_trimst-2-LargeIntestine-Epithelial-neuro-epithelial-L_cells_(PYY+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GCG ISL1 DRD4	3.22e-04	166	36	3	eb9c81fa7573de7aff6670e7dad313f02129809f
ToppCell	facs-Heart-LV-24m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GCG ISL1 INA	3.22e-04	166	36	3	c02c2a68d61dbd7ed086d9b02cfcb1778b8a8656
ToppCell	facs-Heart-LV-24m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GCG ISL1 INA	3.22e-04	166	36	3	20c24a9d2eb67a20e5154d25656da14186034f02
ToppCell	Adult-Mesenchymal-myofibroblast_cell\|Adult / Lineage, Cell type, age group and donor	CACNA1C LTBP2 ENDOG	3.28e-04	167	36	3	d584a8548a5317bd9686b3be8246ae6ed568796b
ToppCell	3'-Child09-12-SmallIntestine-Epithelial-neuro-epithelial-N_cells_(NTS+)\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GCG ISL1 INA	3.45e-04	170	36	3	02f0be0aab8ba2d35a83238609352ef3677511c9
ToppCell	5'-Adult-SmallIntestine-Epithelial-neuro-epithelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GCG ISL1 INA	3.63e-04	173	36	3	30fa8c14c8a1f546f380132c0c28a61e6a2f9fc4
ToppCell	3'-Child04-06-SmallIntestine-Epithelial-neuro-epithelial\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GCG ISL1 INA	3.63e-04	173	36	3	07798461d12d04f3dabff03481c999cb07c5af2f
ToppCell	5'-Adult-LargeIntestine-Epithelial-neuro-epithelial-L_cells_(PYY+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GCG ISL1 INA	3.63e-04	173	36	3	9a3500b06d00d1d4ee42910a3a73327b21beab52
ToppCell	3'-Child04-06-SmallIntestine-Epithelial-neuro-epithelial-N_cells_(NTS+)\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GCG ISL1 INA	3.63e-04	173	36	3	f31e738c2b3b319fb40b0b16b2393a51c9a8999c
ToppCell	5'-Adult-LargeIntestine-Epithelial-neuro-epithelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GCG ISL1 INA	3.70e-04	174	36	3	9f114e61458659005b6d0b4aa30a7a059e7aa5c6
ToppCell	COVID-19-Heart-VSMC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	SORT1 CACNA1C SPEG	3.76e-04	175	36	3	1125f0d3a5b2388fa77a820dea0288e824d84a82
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c12-MKI67-TYROBP\|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)	PIDD1 TEX30 AMDHD2	3.76e-04	175	36	3	86dfce849b2ec023a72f7e887fa681b117155e51
ToppCell	3'-Child09-12-SmallIntestine-Epithelial-neuro-epithelial\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GCG ISL1 INA	3.82e-04	176	36	3	2e1003dc373b14d27f0464d980453fdcfc1005f0
ToppCell	E16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_prolif\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FZD4 ANKRD24 INA	3.88e-04	177	36	3	30f82b04e48940bfcaf2c22677efe6d57ae3f1a7
ToppCell	Children_(3_yrs)-Mesenchymal-airway_smooth_muscle_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CACNA1C LTBP2 SPEG	3.88e-04	177	36	3	b59967219f7d874805768e247c0eb2bc4d4420c8
ToppCell	droplet-Liver-LIVER_HEP-30m-Lymphocytic-B_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GCG ISL1 INA	3.95e-04	178	36	3	d3cbdec9d75f076e565baca05ede292cca7758a4
ToppCell	cellseq2-Mesenchymal-Fibroblastic-Fibroblastic_2-ASMC\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	NCAM2 ANKRD24 SPEG	3.95e-04	178	36	3	8ec2a25dda96c9cc9c2904b6cb18f75a293f4969
ToppCell	cellseq2-Mesenchymal-Fibroblastic-Fibroblastic_2\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	NCAM2 ANKRD24 SPEG	3.95e-04	178	36	3	6c91331196696e0cf239d105f458e3230659fa38
ToppCell	COVID-19-Heart-VSMC\|Heart / Disease (COVID-19 only), tissue and cell type	SORT1 CACNA1C SPEG	4.01e-04	179	36	3	a69ad6912b5c10bb9f9d800f724c792341e9bab1
ToppCell	facs-Heart-RV-24m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SORT1 TTC34 SPEG	4.08e-04	180	36	3	a37cc885fe3f6cb9df69d43358064c83c18412e7
ToppCell	facs-Heart-RV-24m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SORT1 TTC34 SPEG	4.08e-04	180	36	3	63a6d532b16b8b15c7c9102148d7297ee3afd641
ToppCell	metastatic_Brain-Fibroblasts-Myofibroblasts\|metastatic_Brain / Location, Cell class and cell subclass	CACNA1C LTBP2 DRD4	4.15e-04	181	36	3	bd0b5f74f9c81ec0f1592710774a4fdf33d9d5a9
ToppCell	facs-Kidney-nan-3m\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SORT1 FZD4 GCG	4.21e-04	182	36	3	4c5d14e33ebdf117b5aa9e2f57aaa89aa51f72bf
ToppCell	5'-Adult-SmallIntestine-Epithelial-neuro-epithelial-I_cells_(CCK+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GCG ISL1 INA	4.21e-04	182	36	3	27a27a3eaeacb087c9601d5bb1c9e57cdfcd9d77
ToppCell	RA-13._Vascular_Smooth_Muscle\|RA / Chamber and Cluster_Paper	SORT1 CACNA1C SPEG	4.28e-04	183	36	3	818fd886e0188091310825f9145fa53328f2c979
ToppCell	normal-na-Lymphocytic-lymphocyte-male\|normal / PBMC cell types (v2) per disease, treatment status, and sex	ZNF346 RAB11FIP4 TTC34	4.35e-04	184	36	3	2c286712428662bc4589dc5ac4011bf7ed403cb5
ToppCell	Fetal_29-31_weeks-Mesenchymal-airway_smooth_muscle_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CACNA1C LTBP2 SPEG	4.42e-04	185	36	3	e58a009aaf342be019a909747b1895d5987d4daf
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_adventitial_fibro_(9)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	CACNA1C NCAM2 ISL1	4.49e-04	186	36	3	8915436d09775f2828a7678af203b1082b36e21c
ToppCell	droplet-Liver-LIVER_HEP-30m-Lymphocytic-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GCG ISL1 INA	4.49e-04	186	36	3	f5468e03321ea2083e223eb0d92c3a9307039569
ToppCell	Control-Fibroblasts-Alveolar_FB\|Control / group, cell type (main and fine annotations)	CACNA1C NCAM2 LTBP2	4.56e-04	187	36	3	92d468dde81125d51daf7abd4703741abe1ab91c
ToppCell	Fetal_29-31_weeks-Mesenchymal-airway_smooth_muscle_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CACNA1C LTBP2 SPEG	4.63e-04	188	36	3	4d1e5f85342ae550086609d7680e32730b78b5d2
ToppCell	COPD-Stromal-SMC\|Stromal / Disease state, Lineage and Cell class	SORT1 CACNA1C SPEG	4.63e-04	188	36	3	9ffef4b01d0ddd6913c9ed6be79aeaaabd5e41ed
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_myocytic-mes_ASM_(13)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	CACNA1C LTBP2 SPEG	4.70e-04	189	36	3	da9ecc0d7b81c1901f30f97bb44112dc85444a66
ToppCell	PND10\|World / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	LTBP2 MYCBP2 SH3BP5	4.78e-04	190	36	3	d67e2814047c8df2ae4b7bc8be9539f5df6ecef2
ToppCell	Mesenchymal-airway_smooth_muscle_cell\|World / Lineage, Cell type, age group and donor	CACNA1C LTBP2 SPEG	4.78e-04	190	36	3	645e56b02edc3702c7db917b8ecd5eed0decaf71
ToppCell	Control-Fibroblasts\|Control / group, cell type (main and fine annotations)	CACNA1C NCAM2 LTBP2	4.78e-04	190	36	3	3a42a9b98d954685d38a741f44545898d0e3e9ce
ToppCell	droplet-Limb_Muscle-Pre-Sort-18m-Mesenchymal-smooth_muscle_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SORT1 CACNA1C SPEG	4.85e-04	191	36	3	8e8beb8e8a3b33cac83d3f7ce915a71e3654fdab
ToppCell	Control-Stromal-SMC\|Stromal / Disease state, Lineage and Cell class	SORT1 CACNA1C SPEG	4.85e-04	191	36	3	2da83c493e60ad0278848957645277d76737a188
ToppCell	Entopeduncular-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	GIGYF1 INA MYCBP2	4.85e-04	191	36	3	5d24022cec293bc8d9e978ae99a109e660bb8f83
ToppCell	droplet-Limb_Muscle-Pre-Sort-18m-Mesenchymal-unknown\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SORT1 CACNA1C SPEG	4.85e-04	191	36	3	60bc1f3efa7bbad5cb7944fe5e049ea79cd1745a
ToppCell	Entopeduncular-Neuronal-Inhibitory\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	GIGYF1 INA MYCBP2	4.85e-04	191	36	3	73dae4cdea86aec62393ad7303dc7375a6b3fc86
ToppCell	nucseq-Mesenchymal-Fibroblastic-Fibroblastic_2-AF1\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CACNA1C NCAM2 LTBP2	4.85e-04	191	36	3	6688cee34beee4f151ac17fccbc9c26a9aad72e1
ToppCell	nucseq-Mesenchymal-Fibroblastic-Fibroblastic_2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CACNA1C NCAM2 LTBP2	4.92e-04	192	36	3	99ce9e3c4c50cf64ebb62145f2b5420efa0db309
ToppCell	Control-Stromal-Myofibroblast\|Stromal / Disease state, Lineage and Cell class	SORT1 CACNA1C NCAM2	5.00e-04	193	36	3	5896242f713ae5fd1a4ebb63827f15d7279dced2
ToppCell	Adult-Mesenchymal-matrix_fibroblast_1_cell-D231\|Adult / Lineage, Cell type, age group and donor	CACNA1C NCAM2 LTBP2	5.00e-04	193	36	3	ef2f456c094e6e3c6ee81e0668c953cb8d0e1c0a
ToppCell	Control-Stromal-Myofibroblast\|World / Disease state, Lineage and Cell class	CACNA1C NCAM2 LTBP2	5.08e-04	194	36	3	3c2266772c5b56e8e02a461e5193e29588028ee9
ToppCell	Control-Fibroblasts-Intermediate_pathological_FB\|Control / group, cell type (main and fine annotations)	CACNA1C NCAM2 LTBP2	5.08e-04	194	36	3	03a269f75a481ea54aea8e6444605db8d6df493d
ToppCell	droplet-Limb_Muscle-MUSCLE-1m-Mesenchymal-smooth_muscle_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SORT1 CACNA1C SPEG	5.08e-04	194	36	3	b8a130ffae68ffe550bf335460a1ec1035cf8d8d
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_2_cell-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	FZD4 NCAM2 ARHGAP21	5.08e-04	194	36	3	439d3f17c1f4736122b330e98add9292c7036a8e
ToppCell	Control-Stromal-Myofibroblast\|Control / Disease state, Lineage and Cell class	CACNA1C NCAM2 LTBP2	5.15e-04	195	36	3	ffcf76cd72e43d8cf1058a49c76e0956065038bc
ToppCell	Adult-Mesenchymal-matrix_fibroblast_1_cell\|Adult / Lineage, Cell type, age group and donor	CACNA1C NCAM2 LTBP2	5.15e-04	195	36	3	61c9e09fc84d1012e472185d70ad0a06cee30d6e
ToppCell	COVID-19-Fibroblasts-Alveolar_FB\|COVID-19 / group, cell type (main and fine annotations)	CACNA1C NCAM2 LTBP2	5.15e-04	195	36	3	603050beeb33c331d4b2e3fa46cae3f3e0e4bdc7
ToppCell	tumor_Lung-Fibroblasts-Smooth_muscle_cells\|tumor_Lung / Location, Cell class and cell subclass	CACNA1C LTBP2 SPEG	5.15e-04	195	36	3	ea9ff25020c2fcd1bab80e1829af0f4e4777de8b
ToppCell	COPD-Stromal-Myofibroblast\|COPD / Disease state, Lineage and Cell class	CACNA1C NCAM2 LTBP2	5.23e-04	196	36	3	af206bb5bbb8b604a6212acd79878bcc3d326cec
ToppCell	IPF-Stromal-Myofibroblast\|IPF / Disease state, Lineage and Cell class	CACNA1C NCAM2 LTBP2	5.23e-04	196	36	3	2d0a48e49b3b37bb66e33e74c52915911e1f8a74
ToppCell	facs-Skin-Telogen-3m-Epithelial-bulge_keratinocyte\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1C GCG LTBP2	5.23e-04	196	36	3	90edf61116ffcb4f8b6be3d0a05732d59b0a87d5
ToppCell	IPF-Stromal-Myofibroblast\|World / Disease state, Lineage and Cell class	CACNA1C NCAM2 LTBP2	5.23e-04	196	36	3	7fc9894ceb79dab9f0495acc84e2d6d0d1c69bb7
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-1_mon-Neuronal-Subcortical\|1_mon / Sample Type, Dataset, Time_group, and Cell type.	ISL1 INA SH3BP5	5.23e-04	196	36	3	bf8fe28193348342987d361c8e8b9e1d6d542678
ToppCell	facs-Skin-Telogen-3m-Epithelial-outer_bulge\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1C GCG LTBP2	5.23e-04	196	36	3	c936014125b2ed5f796221b74acb77b8f8359875
ToppCell	nucseq-Mesenchymal-Fibroblastic\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CACNA1C NCAM2 LTBP2	5.23e-04	196	36	3	7d8505dac15fa59935ccf592afc54b04c4c6554f
ToppCell	Tracheal-NucSeq-Stromal-Fibroblastic-Fibro_myofibroblast\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CACNA1C NCAM2 LTBP2	5.31e-04	197	36	3	0dd71e399f253787fa546a7e90c5373180b89ffd
ToppCell	COVID-19-Fibroblasts-Intermediate_pathological_FB\|COVID-19 / group, cell type (main and fine annotations)	CACNA1C NCAM2 LTBP2	5.31e-04	197	36	3	f1c8936986123a3151140c374fcd62d6705c530b
ToppCell	COPD-Stromal-Myofibroblast\|World / Disease state, Lineage and Cell class	CACNA1C NCAM2 LTBP2	5.31e-04	197	36	3	d51f484b4e01ac64233950d0b97fa88825ea1dbb
ToppCell	10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte-B\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SORT1 ARHGAP21 SH3BP5	5.31e-04	197	36	3	82b8e22317cad6d3786bd70d91107007c0ccd7cd
ToppCell	5'-GW_trimst-2-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FZD4 NCAM2 SH3BP5	5.31e-04	197	36	3	2744cc94883c5d0424677cf5093bbab622933e9b
ToppCell	COVID-19-Fibroblasts\|COVID-19 / group, cell type (main and fine annotations)	CACNA1C NCAM2 LTBP2	5.31e-04	197	36	3	fb847f2277609c31fffcdf49517243ce0684facf
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-1M-Neuronal-ventral_progenitors_and_neurons_2\|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.	ISL1 INA SH3BP5	5.39e-04	198	36	3	b73b9feb82997b654718aa27f33ca7b454214802
ToppCell	COVID-19-lung-Fibroblast\|lung / Disease (COVID-19 only), tissue and cell type	CACNA1C NCAM2 LTBP2	5.39e-04	198	36	3	df3de77216f5c5d6141ec44d01c56b942f611838
ToppCell	COVID-19-lung-Fibroblast\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CACNA1C NCAM2 LTBP2	5.39e-04	198	36	3	3ec01a55ade5e1627258cc3cfebb2c3207a4cb43
ToppCell	nucseq-Mesenchymal\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CACNA1C NCAM2 LTBP2	5.39e-04	198	36	3	8f52243ca8b9ba68a75ae411506a3a6de258eb97
ToppCell	Tracheal-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_systemic_arterial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SORT1 CACNA1C SPEG	5.39e-04	198	36	3	7dd874b09c81cc512ccc1e9b65f290a5f94d736e
ToppCell	Adult-Mesenchymal\|Adult / Lineage, Cell type, age group and donor	CACNA1C NCAM2 LTBP2	5.39e-04	198	36	3	26e55b409db2a1637c95fae7c54b0abea1ef550c
ToppCell	cellseq-Mesenchymal-Fibroblastic-Fibroblastic_2-AF1\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CACNA1C NCAM2 LTBP2	5.39e-04	198	36	3	f1374f7a50244d59c766ac41f44c08c9117407d2
ToppCell	Parenchymal-10x5prime-Stromal-Myofibroblastic-Muscle_smooth_pulmonary\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	CACNA1C LTBP2 SPEG	5.46e-04	199	36	3	7c272a1aa7f3e931ad5d20809719d85b3bce4cb0
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-1_mon-Neuronal\|1_mon / Sample Type, Dataset, Time_group, and Cell type.	INA SH3BP5 SPINK5	5.46e-04	199	36	3	f94307958cead25d38103fcbb35fa45011de1687
ToppCell	cellseq-Mesenchymal-Fibroblastic-Fibroblastic_2\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CACNA1C NCAM2 LTBP2	5.46e-04	199	36	3	66a79732caf2f04c09b4d9832377aa01ca477677
ToppCell	medial-mesenchymal-Myofibroblast\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	LTBP2 ISL1 SPEG	5.46e-04	199	36	3	e25acdb5809aaff631cb06dbe4c7e59549a0bdb9
ToppCell	medial-2-mesenchymal-Myofibroblast\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	LTBP2 ISL1 SPEG	5.46e-04	199	36	3	95aae608fa35a9c82b12c6f18937ce636750ca44
ToppCell	distal-2-mesenchymal-Airway_Smooth_Muscle\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CACNA1C LTBP2 SPEG	5.46e-04	199	36	3	af226a6c50747dad9ca696463e715913b3ac17c0
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-4M\|organoid_Kanton_Nature / Sample Type, Dataset, Time_group, and Cell type.	INA MYCBP2 SH3BP5	5.46e-04	199	36	3	b2d7dea11207cca63d688f8051143850b29dbdf0
ToppCell	Parenchymal-10x5prime-Stromal-Myofibroblastic\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	CACNA1C LTBP2 SPEG	5.46e-04	199	36	3	20f760d92c351a1dac4cc0a424c443ea03a179fe
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-4M-Neuronal\|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.	INA MYCBP2 SH3BP5	5.46e-04	199	36	3	77b4aa00f14b86ef5db0490be98787e063979541
ToppCell	COVID-19-kidney-Glomerular_EC\|kidney / Disease (COVID-19 only), tissue and cell type	FZD4 CACNA1C SH3BP5	5.46e-04	199	36	3	fffd2f9042b55531dac4e5b463b5cee80402e7bb
Drug	AC1NPPZW	SORT1 CACNA1C INA SPEG SH3BP5	4.31e-07	103	34	5	CID005183170
Disease	restless legs syndrome (implicated_via_orthology)	MEIS3P1 MEIS3P2	3.81e-05	8	35	2	DOID:0050425 (implicated_via_orthology)
Disease	leukemia (implicated_via_orthology)	MEIS3P1 MEIS3P2	2.31e-04	19	35	2	DOID:1240 (implicated_via_orthology)
Disease	resting heart rate	CACNA1C ARHGAP21 SPEG	7.34e-04	149	35	3	EFO_0004351
Disease	blood phosphate measurement	OS9 ANKRD24 INA	1.15e-03	174	35	3	EFO_0010972
Disease	schizophrenia, anorexia nervosa	CACNA1C INA	1.49e-03	48	35	2	MONDO_0005090, MONDO_0005351
Disease	overall survival, pancreatic carcinoma	CACNA1C SBF2	1.55e-03	49	35	2	EFO_0000638, EFO_0002618
Disease	word reading	ZNF346 RAB11FIP4	2.71e-03	65	35	2	EFO_0005300
Disease	keratoconus	PIDD1 RAB11FIP4	2.80e-03	66	35	2	MONDO_0015486

Protein segments in the cluster

Peptide	Gene	Start	Entry
SPECEVERGDRAEGA	SH3BP5	376	O60239
RCEEESRGREGAERA	INA	181	Q16352
VECEDPFDLRLVGGD	CD5L	236	O43866
REVPREEGAACGESE	ANKRD24	516	Q8TF21
LREVFEVCGRDPDGF	RAB11FIP4	21	Q86YS3
EVCGRDPDGFLRVER	RAB11FIP4	26	Q86YS3
RRCRAPEGFEEDKDG	GIGYF1	276	O75420
AVCRDGEEEFPFERR	GGNBP2	6	Q9H3C7
CEGLRVLLDPDGREE	SBF2	886	Q86WG5
PFVRDGRLGCTREND	SPINK5	166	Q9NQ38
AGEDVRFLCRAEGEP	LINGO3	421	P0C6S8
GRGRRDFPEEVAIVE	GCG	126	P01275
GQEGRGEPRDDLDRC	OC90	331	Q02509
DVRGRDPAVCRLEDR	DRD4	176	P21917
GCPGEDVERAQRLRD	FAM74A7	61	A6NL05
LVIEDRDGGCREDFE	MEIS3P2	156	A8K0S8
LGPARGFGDEEERRC	FZD4	31	Q9ULV1
GFGDEEERRCDPIRI	FZD4	36	Q9ULV1
DAGCVRARGRPSEEE	CACNA1C	2196	Q13936
SGFRGARCEEVIPDE	LTBP2	211	Q14767
AFERGIDVDADRPDC	PIDD1	671	Q9HB75
DLVIEDRDGGCREDF	MEIS3P1	71	A6NDR6
GVRECREPELGLEEL	HSPBP1	306	Q9NZL4
LEGPEGVRGRECFLR	STK11IP	546	Q8N1F8
RRSAPGEDEECGRVR	SORT1	76	Q99523
PERLRGDGDRRECDF	ENDOG	101	Q14249
EAGRGDDYDPRELIC	MYCBP2	4561	O75592
PGDEFALREDGLFCR	ISL1	116	P61371
RPREAEVRFLCDEGA	OS9	186	Q13438
FREDCPPDREELGRH	GFER	91	P55789
CEGRVEARGEIDFRD	NCAM2	186	O15394
PDQRRFAEEAEGGLC	SPEG	911	Q15772
RSEERGPFRGAEEED	SPEG	2356	Q15772
PEEGALRVRGGEDRC	SCART1	781	Q4G0T1
EPDDGDDFVRGLICI	TEX30	116	Q5JUR7
LEGQEPDGVRFDRER	ZNF346	26	Q9UL40
FTEQDDRRGICERPR	ARHGAP21	531	Q5T5U3
GDGDLPRRAEDFCRQ	TTC34	456	A8MYJ7
EDDGCLLEQEPRGRR	nan	11	Q8N7P7
FEERRVADERRDCGG	AMDHD2	46	Q9Y303
RFGEGVERELFVREP	MYORG	401	Q6NSJ0