Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	VWFA	VWF HMCN1 COL6A5 ITGAL ITGB8	3.20e-05	82	83	5	PS50234
Domain	VWA	VWF HMCN1 COL6A5 ITGAL ITGB8	3.60e-05	84	83	5	SM00327
Domain	VWF_A	VWF HMCN1 COL6A5 ITGAL ITGB8	7.91e-05	99	83	5	IPR002035
Domain	DUF3504	ZMYM2 ZMYM4	1.93e-04	5	83	2	IPR021893
Domain	DUF3504	ZMYM2 ZMYM4	1.93e-04	5	83	2	PF12012
Domain	-	VWF HMCN1 COL6A5 ITGB8	3.29e-04	74	83	4	3.40.50.410
Domain	Znf_MYM	ZMYM2 ZMYM4	4.04e-04	7	83	2	IPR010507
Domain	zf-FCS	ZMYM2 ZMYM4	4.04e-04	7	83	2	PF06467
Domain	TRASH_dom	ZMYM2 ZMYM4	5.37e-04	8	83	2	IPR011017
Domain	TRASH	ZMYM2 ZMYM4	5.37e-04	8	83	2	SM00746
Domain	VWC	VWF CHRDL1 TECTA	6.38e-04	38	83	3	SM00214
Domain	VWFC_2	VWF CHRDL1 TECTA	6.38e-04	38	83	3	PS50184
Domain	Plexin_cytopl	PLXNA4 PLXNA2	6.88e-04	9	83	2	PF08337
Domain	Plexin_cytoplasmic_RasGAP_dom	PLXNA4 PLXNA2	6.88e-04	9	83	2	IPR013548
Domain	Plexin	PLXNA4 PLXNA2	6.88e-04	9	83	2	IPR031148
Domain	VWF_dom	VWF CHRDL1 TECTA	8.57e-04	42	83	3	IPR001007
Domain	PSI	PLXNA4 ITGB8 PLXNA2	9.83e-04	44	83	3	IPR016201
Domain	PSI	PLXNA4 ITGB8 PLXNA2	1.12e-03	46	83	3	SM00423
Domain	TIL	VWF TECTA	1.25e-03	12	83	2	PF01826
Domain	C8	VWF TECTA	1.25e-03	12	83	2	PF08742
Domain	Unchr_dom_Cys-rich	VWF TECTA	1.47e-03	13	83	2	IPR014853
Domain	C8	VWF TECTA	1.47e-03	13	83	2	SM00832
Domain	TIL_dom	VWF TECTA	1.72e-03	14	83	2	IPR002919
Domain	VWA	VWF COL6A5 ITGAL	1.98e-03	56	83	3	PF00092
Domain	VWD	VWF TECTA	2.25e-03	16	83	2	SM00216
Domain	VWF_type-D	VWF TECTA	2.25e-03	16	83	2	IPR001846
Domain	Disintegrin_CS	ADAM18 ADAM7	2.25e-03	16	83	2	IPR018358
Domain	VWFD	VWF TECTA	2.25e-03	16	83	2	PS51233
Domain	VWD	VWF TECTA	2.25e-03	16	83	2	PF00094
Domain	EGF_extracell	RELN ADAM18 ITGB8	2.41e-03	60	83	3	IPR013111
Domain	EGF_2	RELN ADAM18 ITGB8	2.41e-03	60	83	3	PF07974
Domain	Znf_C2H2-like	ZNF597 RLF ZNF750 ZNF677 ZNF175 ZNF267 FOXP1 BCL11A ZNF99 ZXDB	2.73e-03	796	83	10	IPR015880
Domain	ADAM_CR	ADAM18 ADAM7	2.85e-03	18	83	2	PF08516
Domain	Znf_C2H2	ZNF597 RLF ZNF750 ZNF677 ZNF175 ZNF267 FOXP1 BCL11A ZNF99 ZXDB	2.96e-03	805	83	10	IPR007087
Domain	ZnF_C2H2	ZNF597 RLF ZNF750 ZNF677 ZNF175 ZNF267 FOXP1 BCL11A ZNF99 ZXDB	3.04e-03	808	83	10	SM00355
Domain	VWC_out	VWF TECTA	3.18e-03	19	83	2	SM00215
Domain	-	ADAM18 ADAM7	3.52e-03	20	83	2	4.10.70.10
Domain	Disintegrin	ADAM18 ADAM7	3.88e-03	21	83	2	PF00200
Domain	DISIN	ADAM18 ADAM7	3.88e-03	21	83	2	SM00050
Domain	Integrin_dom	ITGAL ITGB8	5.48e-03	25	83	2	IPR032695
Domain	IPT	PLXNA4 PLXNA2	6.37e-03	27	83	2	SM00429
Domain	ACR	ADAM18 ADAM7	6.37e-03	27	83	2	SM00608
Domain	ADAM_Cys-rich	ADAM18 ADAM7	6.37e-03	27	83	2	IPR006586
Domain	VWC	VWF CHRDL1	6.84e-03	28	83	2	PF00093
Domain	ZINC_FINGER_C2H2_2	ZNF597 RLF ZNF677 ZNF175 ZNF267 FOXP1 BCL11A ZNF99 ZXDB	7.38e-03	775	83	9	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF597 RLF ZNF677 ZNF175 ZNF267 FOXP1 BCL11A ZNF99 ZXDB	7.50e-03	777	83	9	PS00028
Domain	TIG	PLXNA4 PLXNA2	8.35e-03	31	83	2	PF01833
Domain	Sema	PLXNA4 PLXNA2	8.35e-03	31	83	2	SM00630
Domain	Semap_dom	PLXNA4 PLXNA2	8.35e-03	31	83	2	IPR001627
Domain	Sema	PLXNA4 PLXNA2	8.35e-03	31	83	2	PF01403
Domain	SEMA	PLXNA4 PLXNA2	8.35e-03	31	83	2	PS51004
Pubmed	Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication.	VWF DLGAP4 DCP2 NUP98 DDX23 BCL11A MYRF EPAS1	4.87e-07	283	85	8	18854154
Pubmed	von Willebrand Factor and Angiopoietin-2 are Sensitive Biomarkers of Pulsatility in Continuous-Flow Ventricular Assist Device Patients.	VWF ANGPT2	5.90e-06	2	85	2	37000917
Pubmed	von Willebrand factor binds to angiopoietin-2 within endothelial cells and after release from Weibel-Palade bodies.	VWF ANGPT2	5.90e-06	2	85	2	37011710
Pubmed	Chordin Like-1 Regulates Osteoblast and Adipocyte Differentiation Through Stabilizing Insulin-Like Growth Factor Binding Protein 3.	IGFBP3 CHRDL1	5.90e-06	2	85	2	36682027
Pubmed	Roles of claudin-5 and von Willebrand factor in patients with rheumatoid arthritis.	VWF CLDN5	5.90e-06	2	85	2	25973092
Pubmed	Plexin-A3 mediates semaphorin signaling and regulates the development of hippocampal axonal projections.	RELN PLXNA4 PLXNA2	9.35e-06	17	85	3	11683995
Pubmed	PlexinD1 and semaphorin signaling are required in endothelial cells for cardiovascular development.	VWF PLXNA2 EDNRA	1.33e-05	19	85	3	15239958
Pubmed	Structural Basis for Plexin Activation and Regulation.	PLXNA4 PLXNA2	1.77e-05	3	85	2	27397516
Pubmed	Interactions between plexin-A2, plexin-A4, and semaphorin 6A control lamina-restricted projection of hippocampal mossy fibers.	PLXNA4 PLXNA2	1.77e-05	3	85	2	17296555
Pubmed	Role of transmembrane semaphorin Sema6A in oligodendrocyte differentiation and myelination.	PLXNA4 PLXNA2	1.77e-05	3	85	2	22777942
Pubmed	Characterization of the zinc finger proteins ZMYM2 and ZMYM4 as novel B-MYB binding proteins.	ZMYM2 ZMYM4	1.77e-05	3	85	2	32439918
Pubmed	Misexpression of Dickkopf-1 in endothelial cells, but not in chondrocytes or hypertrophic chondrocytes, causes defects in endochondral ossification.	DKK1 EPAS1	1.77e-05	3	85	2	22407773
Pubmed	Repulsive and attractive semaphorins cooperate to direct the navigation of cardiac neural crest cells.	PLXNA4 PLXNA2	1.77e-05	3	85	2	18625214
Pubmed	Association of EDNRA, but not WNK4 or FKBP1B, polymorphisms with essential hypertension.	FKBP1B EDNRA	1.77e-05	3	85	2	14616768
Pubmed	Characterization of Foxp2 and Foxp1 mRNA and protein in the developing and mature brain.	RELN FOXP1	1.77e-05	3	85	2	12687690
Pubmed	Vascular development in the mouse embryonic pancreas and lung.	VWF ANGPT2	1.77e-05	3	85	2	10359181
Pubmed	Mon2, a relative of large Arf exchange factors, recruits Dop1 to the Golgi apparatus.	MON2 DOP1B	1.77e-05	3	85	2	16301316
Pubmed	The structural role of radial glial endfeet in confining spinal motor neuron somata is controlled by the Reelin and Notch pathways.	RELN FOXP1 PLXNA2	3.52e-05	26	85	3	23988635
Pubmed	Chromosome assignment of four plexin A genes (Plxna1, Plxna2, Plxna3, Plxna4) in mouse, rat, Syrian hamster and Chinese hamster.	PLXNA4 PLXNA2	3.53e-05	4	85	2	11306810
Pubmed	PlexinA polymorphisms mediate the developmental trajectory of human corpus callosum microstructure.	PLXNA4 PLXNA2	3.53e-05	4	85	2	25518740
Pubmed	Targeted disruption of semaphorin 3C leads to persistent truncus arteriosus and aortic arch interruption.	PLXNA2 EDNRA	3.53e-05	4	85	2	11688556
Pubmed	Autophagy mediates HIF2α degradation and suppresses renal tumorigenesis.	LAMP1 EPAS1	3.53e-05	4	85	2	24998849
Pubmed	Expression of Cux-1 and Cux-2 in the developing somatosensory cortex of normal and barrel-defective mice.	RELN SLC18A2	3.53e-05	4	85	2	16419078
Pubmed	Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.	IGFBP3 CD109 CNTN3 LAMP1 C4BPB MERTK	4.12e-05	257	85	6	16335952
Pubmed	Guidance-cue control of horizontal cell morphology, lamination, and synapse formation in the mammalian outer retina.	PLXNA4 PLXNA2	5.87e-05	5	85	2	22593055
Pubmed	Expression of the forkhead transcription factor FOXP1 is associated both with hypoxia inducible factors (HIFs) and the androgen receptor in prostate cancer but is not directly regulated by androgens or hypoxia.	FOXP1 EPAS1	5.87e-05	5	85	2	17477366
Pubmed	The mitochondrial targeting chaperone 14-3-3ε regulates a RIG-I translocon that mediates membrane association and innate antiviral immunity.	PLAAT4 TRAT1	5.87e-05	5	85	2	22607805
Pubmed	Mucolipin co-deficiency causes accelerated endolysosomal vacuolation of enterocytes and failure-to-thrive from birth to weaning.	LAMP1 MCOLN3	5.87e-05	5	85	2	25521295
Pubmed	SNX3-retromer requires an evolutionary conserved MON2:DOPEY2:ATP9A complex to mediate Wntless sorting and Wnt secretion.	MON2 DOP1B	5.87e-05	5	85	2	30213940
Pubmed	Cyclin-dependent kinase 9-cyclin K functions in the replication stress response.	CLSPN CCNK	5.87e-05	5	85	2	20930849
Pubmed	The GARP/Latent TGF-β1 complex on Treg cells modulates the induction of peripherally derived Treg cells during oral tolerance.	CD109 ITGB8	5.87e-05	5	85	2	27062243
Pubmed	Single-cell transcriptomic analysis of mouse neocortical development.	RELN SLC18A2 PLXNA4 NEB EPAS1	6.29e-05	170	85	5	30635555
Pubmed	Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.	RELN VWF HMCN1 COL6A5 PLXNA2	7.22e-05	175	85	5	28071719
Pubmed	Semaphorin-Plexin signaling influences early ventral telencephalic development and thalamocortical axon guidance.	PLXNA4 PLXNA2	8.80e-05	6	85	2	28438183
Pubmed	Elucidating mechanisms of osteogenesis in human adipose-derived stromal cells via microarray analysis.	IGFBP3 DKK1	8.80e-05	6	85	2	20613589
Pubmed	Genetic polymorphisms of EPHX1, Gsk3beta, TNFSF8 and myeloma cell DKK-1 expression linked to bone disease in myeloma.	DKK1 TNFSF8	8.80e-05	6	85	2	19657367
Pubmed	Genetic dissection of the Canq1 locus governing variation in extent of the collateral circulation.	ANGPT2 ITGAL	8.80e-05	6	85	2	22412848
Pubmed	Roles of semaphorin-6B and plexin-A2 in lamina-restricted projection of hippocampal mossy fibers.	PLXNA4 PLXNA2	8.80e-05	6	85	2	20484647
Pubmed	Nano-scale architecture of blood-brain barrier tight-junctions.	LAMP1 CLDN5	8.80e-05	6	85	2	34951586
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	CDK8 MON2 RLF DENND5B SLC44A1 ALKBH8 YLPM1 OR4D1 CLDN5 ZSWIM6 CLSPN ZMYM4	9.10e-05	1327	85	12	32694731
Pubmed	A novel p53 regulator, C16ORF72/TAPR1, buffers against telomerase inhibition.	ZNF175 YLPM1 NUP98 SLC17A8 DDX23 ZMYM4 DOP1B	9.19e-05	431	85	7	33660365
Pubmed	Functional proteomics mapping of a human signaling pathway.	RLF VWF DKK1 YLPM1 ZMYM2 ROCK1 MERTK EPAS1	1.01e-04	591	85	8	15231748
Pubmed	Semaphorin-6A controls guidance of corticospinal tract axons at multiple choice points.	PLXNA4 PLXNA2	1.23e-04	7	85	2	19063725
Pubmed	Increased proximal bifurcation of CA1 pyramidal apical dendrites in sema3A mutant mice.	PLXNA4 PLXNA2	1.23e-04	7	85	2	19655386
Pubmed	DCX, a new mediator of the JNK pathway.	RELN MAP3K12	1.23e-04	7	85	2	14765123
Pubmed	The expression of plexins during mouse embryogenesis.	PLXNA4 PLXNA2	1.64e-04	8	85	2	15661641
Pubmed	Heat stable antigen (mouse CD24) supports myeloid cell binding to endothelial and platelet P-selectin.	VWF ITGAL	1.64e-04	8	85	2	8562500
Pubmed	Transcriptional regulation during development of the ductus arteriosus.	EPAS1 EDNRA	1.64e-04	8	85	2	18635823
Pubmed	Tumor necrosis factor disrupts claudin-5 endothelial tight junction barriers in two distinct NF-κB-dependent phases.	ROCK1 CLDN5	1.64e-04	8	85	2	25816133
Pubmed	Integration of opposing semaphorin guidance cues in cortical axons.	PLXNA4 PLXNA2	1.64e-04	8	85	2	22368082
Pubmed	A human MAP kinase interactome.	VWF ZNF175 NUP98 ZMYM2 NEB SS18 EPAS1	1.92e-04	486	85	7	20936779
Pubmed	The role of neuropilins in cell signalling.	PLXNA4 PLXNA2	2.10e-04	9	85	2	19909241
Pubmed	Foxg1 suppresses early cortical cell fate.	RELN FOXP1	2.10e-04	9	85	2	14704420
Pubmed	Semaphorin 6A in Retinal Ganglion Cells Regulates Functional Specialization of the Inner Retina.	PLXNA4 PLXNA2	2.10e-04	9	85	2	38014224
Pubmed	Embryonic stem cell tumor model reveals role of vascular endothelial receptor tyrosine phosphatase in regulating Tie2 pathway in tumor angiogenesis.	ANGPT2 NEB	2.10e-04	9	85	2	20018779
Pubmed	Genetic interactions between doublecortin and doublecortin-like kinase in neuronal migration and axon outgrowth.	RELN FOXP1	2.10e-04	9	85	2	16387638
Pubmed	Autotaxin/lysophospholipase D-mediated lysophosphatidic acid signaling is required to form distinctive large lysosomes in the visceral endoderm cells of the mouse yolk sac.	LAMP1 ROCK1	2.10e-04	9	85	2	19808661
Pubmed	Interaction network of human early embryonic transcription factors.	RLF NUP98 ZMYM2 FOXP1 BCL11A ZMYM4	2.27e-04	351	85	6	38297188
Pubmed	Plexin A3 and plexin A4 convey semaphorin signals during facial nerve development.	PLXNA4 PLXNA2	2.62e-04	10	85	2	18804103
Pubmed	An extracellular biochemical screen reveals that FLRTs and Unc5s mediate neuronal subtype recognition in the retina.	PLXNA4 CNTN3 PLXNA2	2.86e-04	52	85	3	26633812
Pubmed	Positive selection in the adhesion domain of Mus sperm Adam genes through gene duplications and function-driven gene complex formations.	ADAM18 ADAM7	3.20e-04	11	85	2	24079728
Pubmed	On and off retinal circuit assembly by divergent molecular mechanisms.	PLXNA4 PLXNA2	3.83e-04	12	85	2	24179230
Pubmed	Deletion of Sema3a or plexinA1/plexinA3 causes defects in sensory afferent projections of statoacoustic ganglion neurons.	PLXNA4 PLXNA2	3.83e-04	12	85	2	23991118
Pubmed	Functional loss of semaphorin 3C and/or semaphorin 3D and their epistatic interaction with ret are critical to Hirschsprung disease liability.	PLXNA4 PLXNA2	3.83e-04	12	85	2	25839327
Pubmed	PLXNA1 and PLXNA3 cooperate to pattern the nasal axons that guide gonadotropin-releasing hormone neurons.	PLXNA4 PLXNA2	3.83e-04	12	85	2	31690636
Pubmed	Abnormal development of the cerebral cortex and cerebellum in the setting of lamin B2 deficiency.	RELN FOXP1	3.83e-04	12	85	2	20145110
Pubmed	Transcriptome profiling reveals expression signatures of cranial neural crest cells arising from different axial levels.	PLXNA4 PLXNA2	3.83e-04	12	85	2	28407732
Pubmed	Transmembrane semaphorin signalling controls laminar stratification in the mammalian retina.	PLXNA4 PLXNA2	3.83e-04	12	85	2	21270798
Pubmed	Pocket proteins pRb and p107 are required for cortical lamination independent of apoptosis.	RELN FOXP1	3.83e-04	12	85	2	24056077
Pubmed	Cytoplasmic plaque formation in hemidesmosome development is dependent on SoxF transcription factor function.	VWF CLDN5	4.52e-04	13	85	2	22962592
Pubmed	Plexin signaling via off-track and rho family GTPases.	PLXNA4 PLXNA2	4.52e-04	13	85	2	11604131
Pubmed	Semaphorin3A, Neuropilin-1, and PlexinA1 are required for lymphatic valve formation.	PLXNA4 PLXNA2	4.52e-04	13	85	2	22723296
Pubmed	ZNF198 stabilizes the LSD1-CoREST-HDAC1 complex on chromatin through its MYM-type zinc fingers.	ZMYM2 ZMYM4	4.52e-04	13	85	2	18806873
Pubmed	Functional assembly of accessory optic system circuitry critical for compensatory eye movements.	PLXNA4 PLXNA2	4.52e-04	13	85	2	25959730
Pubmed	von Hippel-Lindau protein regulates transition from the fetal to the adult circulatory system in retina.	ANGPT2 EPAS1	4.52e-04	13	85	2	20388654
Pubmed	Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates.	PLXNA4 PLXNA2	4.52e-04	13	85	2	10520995
Pubmed	Myc regulates embryonic vascular permeability and remodeling.	ANGPT2 CLDN5	4.52e-04	13	85	2	19407242
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	MON2 DLGAP4 BCL11A ZSWIM6 PLXNA2 DOP1B	4.97e-04	407	85	6	12693553
Pubmed	Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.	CDK8 YLPM1 ZMYM2 FOXP1 CCNK	5.19e-04	268	85	5	33640491
Pubmed	Transcription factor KLF7 is important for neuronal morphogenesis in selected regions of the nervous system.	RELN FOXP1	5.27e-04	14	85	2	15964824
Pubmed	Capillary cell-type specialization in the alveolus.	VWF CLDN5	5.27e-04	14	85	2	33057196
Pubmed	Venous endothelin modulates responsiveness of cardiac sympathetic axons to arterial semaphorin.	PLXNA4 EDNRA	5.27e-04	14	85	2	30735130
Pubmed	The c-Jun N-terminal kinase activator dual leucine zipper kinase regulates axon growth and neuronal migration in the developing cerebral cortex.	RELN MAP3K12	5.27e-04	14	85	2	17108173
Pubmed	A midline switch of receptor processing regulates commissural axon guidance in vertebrates.	PLXNA4 PLXNA2	5.27e-04	14	85	2	20159958
Pubmed	Angiopoietin-1 is required for Schlemm's canal development in mice and humans.	VWF ANGPT2	5.27e-04	14	85	2	29106382
Pubmed	Loss of BAF (mSWI/SNF) Complexes Causes Global Transcriptional and Chromatin State Changes in Forebrain Development.	RELN FOXP1 SS18	5.52e-04	65	85	3	26655900
Pubmed	The role of neural crest during cardiac development in a mouse model of DiGeorge syndrome.	PLXNA2 EDNRA	6.07e-04	15	85	2	12413905
Pubmed	Cardiac outflow tract defects in mice lacking ALK2 in neural crest cells.	PLXNA2 EDNRA	6.07e-04	15	85	2	15226263
Pubmed	Role of LTBP4 in alveolarization, angiogenesis, and fibrosis in lungs.	VWF ANGPT2	6.07e-04	15	85	2	28684544
Pubmed	Endothelin-2 signaling in the neural retina promotes the endothelial tip cell state and inhibits angiogenesis.	ANGPT2 EDNRA	6.07e-04	15	85	2	24043815
Pubmed	In the developing cerebral cortex: axonogenesis, synapse formation, and synaptic plasticity are regulated by SATB2 target genes.	PLXNA4 PLXNA2	6.07e-04	15	85	2	36028553
Pubmed	Notch pathway targets proangiogenic regulator Sox17 to restrict angiogenesis.	VWF ANGPT2	6.07e-04	15	85	2	24755984
Pubmed	Allocation of paraventricular and supraoptic neurons requires Sim1 function: a role for a Sim1 downstream gene PlexinC1.	PLXNA4 PLXNA2	6.93e-04	16	85	2	17356169
Pubmed	Optic chiasm presentation of Semaphorin6D in the context of Plexin-A1 and Nr-CAM promotes retinal axon midline crossing.	PLXNA4 PLXNA2	6.93e-04	16	85	2	22632726
Pubmed	Expression of the semaphorins Sema 3D and Sema 3F in the developing parathyroid and thymus.	PLXNA4 PLXNA2	6.93e-04	16	85	2	18489001
Pubmed	TAG-1 Multifunctionality Coordinates Neuronal Migration, Axon Guidance, and Fasciculation.	PLXNA4 FOXP1	6.93e-04	16	85	2	31995756
Pubmed	Impaired Reelin-Dab1 Signaling Contributes to Neuronal Migration Deficits of Tuberous Sclerosis Complex.	RELN FOXP1	6.93e-04	16	85	2	26235615
Pubmed	Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction.	IGFBP3 DKK1	7.84e-04	17	85	2	21076409
Pubmed	Different roles of Runx2 during early neural crest-derived bone and tooth development.	IGFBP3 DKK1	7.84e-04	17	85	2	16813524
Pubmed	Semaphorin signaling facilitates cleft formation in the developing salivary gland.	PLXNA4 PLXNA2	7.84e-04	17	85	2	17626059
GeneFamily	Zinc fingers MYM-type	ZMYM2 ZMYM4	1.95e-04	6	66	2	86
GeneFamily	Plexins	PLXNA4 PLXNA2	4.65e-04	9	66	2	683
Coexpression	NABA_MATRISOME	RELN VWF ANGPT2 IGFBP3 HMCN1 ADAM18 TNFSF8 SERPINB11 ADAM7 CD109 PLXNA4 CHRDL1 COL6A5 TECTA PLXNA2	7.77e-07	1008	85	15	MM17056
Coexpression	NABA_MATRISOME	RELN VWF ANGPT2 IGFBP3 HMCN1 ADAM18 TNFSF8 SERPINB11 ADAM7 CD109 PLXNA4 CHRDL1 COL6A5 TECTA PLXNA2	9.70e-07	1026	85	15	M5889
Coexpression	GSE29949_MICROGLIA_VS_DC_BRAIN_DN	RLF TNFSF8 PLCH2 CLDN5 NEB MYRF ITGB8	3.91e-06	199	85	7	M8405
ToppCell	10x5'v1-week_17-19-Myeloid_neutrophil-granulo-eo/baso/mast-eosinophil\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	ANGPT2 ZNF175 ZNF99 FKBP1B ITGB8 EPAS1 PLXNA2	5.33e-08	179	85	7	d16dc58b5b22762a5a3c875563ced18022d08908
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-Newborn\|World / Primary Cells by Cluster	ANK2 PLXNA4 CHRDL1 BCL11A ZSWIM6 PLXNA2 DOP1B	9.90e-08	196	85	7	9401bd84798f0ea3e986e94135a9e1dc5643330f
ToppCell	Endothelial-A-IPF_04\|World / lung cells shred on cell class, cell subclass, sample id	DENND5B VWF IGFBP3 PLXNA4 CLDN5 EPAS1	1.19e-06	178	85	6	2f2602b9305d55f25afa9861dd6c6347ae179337
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_artery-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	VWF IGFBP3 HMCN1 CLDN5 EPAS1 PLXNA2	1.49e-06	185	85	6	a7ae76058b2082020cadec49d63b9f4e24d21734
ToppCell	LV-10._Endothelium_II\|World / Chamber and Cluster_Paper	VWF HMCN1 FOXP1 TECTA EPAS1 PLXNA2	1.58e-06	187	85	6	7876dcb4800c2e54874df3d933efb79307a64a97
ToppCell	Endothelial-B-IPF_03\|World / lung cells shred on cell class, cell subclass, sample id	RELN VWF NUP98 CHRDL1 CLDN5 ZNF99	1.63e-06	188	85	6	ecb74d67314a43b5805b7f2a7bb9ff6c5a60200a
ToppCell	LPS-IL1RA-Endothelial-Endothelial-Artery\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	VWF IGFBP3 HMCN1 CD109 CLDN5 MERTK	1.74e-06	190	85	6	aed65d584ca0c25f6a8313c66b421a6618af82ea
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb-3m-Endothelial-endothelial_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DENND5B VWF IGFBP3 CLDN5 EPAS1 PLXNA2	1.74e-06	190	85	6	38a815abf0ac5cac6071737cadc54a514f62d37d
ToppCell	COVID-19-kidney-AQP1+SLC14A1+EC\|kidney / Disease (COVID-19 only), tissue and cell type	VWF IGFBP3 CD109 CLDN5 EPAS1 PLXNA2	1.74e-06	190	85	6	1519f34d31fe0817184c5865a0bc9f0cb479b1a4
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb-3m-Endothelial\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DENND5B VWF IGFBP3 CLDN5 EPAS1 PLXNA2	1.74e-06	190	85	6	bb1476b44dd49e1dd52a636a91c4600b6d4fbe2e
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb-3m-Endothelial-nan\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DENND5B VWF IGFBP3 CLDN5 EPAS1 PLXNA2	1.74e-06	190	85	6	d180205c70b5ca9bc5a01a2e6cb42fcebc7f630d
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_arterial-A\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	VWF ANGPT2 HMCN1 CLDN5 EPAS1 PLXNA2	1.90e-06	193	85	6	3f8280ef849d95b2fcea5e6824b95a07febc96d0
ToppCell	LV-10._Endothelium_II\|LV / Chamber and Cluster_Paper	VWF HMCN1 FOXP1 TECTA EPAS1 PLXNA2	1.96e-06	194	85	6	b6cc849fa08599bff9839ef382d190cc964e273e
ToppCell	3'-Adult-LymphNode-Endothelial-blood_vessel_EC-arterial_capillary\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ZNF750 VWF IGFBP3 CLDN5 EPAS1 MCOLN3	1.96e-06	194	85	6	622461e5f9c648252a2f6ec84e7565220a803132
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_mature-Endo_arterial-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	VWF ANGPT2 HMCN1 CLDN5 EPAS1 PLXNA2	2.02e-06	195	85	6	4658fb197657d7692ee344ae76b11b0210c418ba
ToppCell	wk_15-18-Endothelial-Blood_vessel_endothelial-Venous_endo\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	VWF HMCN1 CD109 FOXP1 CLDN5 EPAS1	2.02e-06	195	85	6	cc3d6f98d310e8840ff497d7258c5ccf54e6c624
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_immature\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	VWF ANGPT2 HMCN1 CLDN5 EPAS1 PLXNA2	2.14e-06	197	85	6	62c0a90869431e582bb7bb329e0b0cc59123d3d1
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_mature-Endo_capilar\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	VWF ANGPT2 IGFBP3 HMCN1 CLDN5 EPAS1	2.14e-06	197	85	6	e567f91fa398fd306d025dcfe89bd50a60216537
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_airway_basal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	IGFBP3 SERPINB11 PLCH2 CNTN3 BCL11A ITGB8	2.14e-06	197	85	6	107cb153ea7fc74bbd244dbb9d0499c0a8506724
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_immature-Tip-like-A\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	VWF ANGPT2 HMCN1 CLDN5 EPAS1 PLXNA2	2.14e-06	197	85	6	9e948b2e0f7e426f1e6f95bbbf4282fbddc2b99d
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_immature-Tip-like\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	VWF ANGPT2 HMCN1 CLDN5 EPAS1 PLXNA2	2.14e-06	197	85	6	16f0eb047df9d702518f82ee99c6e7dc1350b2fb
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_capilar-G\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	VWF ANGPT2 IGFBP3 CLDN5 EPAS1 PLXNA2	2.21e-06	198	85	6	0a4626b51ba8b52acbaf616f0ced850079cd7149
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_mature\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	VWF ANGPT2 HMCN1 CLDN5 EPAS1 PLXNA2	2.21e-06	198	85	6	218f33e068eb126458ec33176de3cfa6fc06ddf0
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_immature-Tip-like-A\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	VWF ANGPT2 IGFBP3 HMCN1 CLDN5 EPAS1	2.21e-06	198	85	6	72e8b9cccb7b0a2ea9d415218fff4fa2f09728f4
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Endothelial\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	VWF ANGPT2 HMCN1 CLDN5 EPAS1 PLXNA2	2.21e-06	198	85	6	e1fa02184ce93c4f8aa5cf04b70949cd4c425ff0
ToppCell	ASK428-Endothelial\|ASK428 / Donor, Lineage and Cell class of Lung cells from Dropseq	RELN VWF ANGPT2 CHRDL1 CLDN5 EPAS1	2.21e-06	198	85	6	d69d0ff115298596173a4278897a65007a71f5df
ToppCell	5'-Adult-Appendix-Endothelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RELN VWF ANGPT2 IGFBP3 CLDN5 EPAS1	2.21e-06	198	85	6	90e85fe7a0ab376a41666dfff6c0e95b7f1c9475
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_mature-Endo_arterial\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	VWF ANGPT2 HMCN1 CLDN5 EPAS1 PLXNA2	2.21e-06	198	85	6	7cddd474416651088a4e08edfc0ac420ff10a5fe
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_immature\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	VWF ANGPT2 IGFBP3 HMCN1 CLDN5 EPAS1	2.27e-06	199	85	6	9c40b3ee39860e9d8edafd007daec11abdd95435
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_immature-Tip-like\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	VWF ANGPT2 IGFBP3 HMCN1 CLDN5 EPAS1	2.27e-06	199	85	6	72b34bce8157abe389e95cd3ed8ba578dce0cbf6
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_capilar-F\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	VWF ANGPT2 HMCN1 CLDN5 EPAS1 PLXNA2	2.27e-06	199	85	6	236b1417ed0875e98c6ec1ec714003bfce438d65
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_capilar-A\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	VWF ANGPT2 IGFBP3 HMCN1 CLDN5 EPAS1	2.27e-06	199	85	6	c5c12c8288fe868322bae9d691b91fee953ceb3e
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_immature-Tip-like-G\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	VWF ANGPT2 DKK1 HMCN1 CLDN5 EDNRA	2.27e-06	199	85	6	1295f34a350bf48987e2fad411aaac3630efd3f1
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_arterial\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	VWF ANGPT2 HMCN1 CLDN5 EPAS1 PLXNA2	2.27e-06	199	85	6	0602e2b2aa56d106da63bd342a38bef437b4d496
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW16-Neuronal\|GW16 / Sample Type, Dataset, Time_group, and Cell type.	DLGAP4 PLXNA4 BCL11A ZSWIM6 PLXNA2 DOP1B	2.34e-06	200	85	6	84e4565d28a02700bf7f6730d1b3a58744ca0aea
ToppCell	3'-Adult-LargeIntestine-Endothelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RELN VWF ANGPT2 IGFBP3 CLDN5 EPAS1	2.34e-06	200	85	6	74a3b9ec8faa1d187ad8b0d12f5c89bde2d7248e
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	VWF ANGPT2 HMCN1 CLDN5 EPAS1 PLXNA2	2.34e-06	200	85	6	86ec951234015ced7126b016199e5869a0f22478
ToppCell	LPS_only-Endothelial-Endothelial-Artery\|LPS_only / Treatment groups by lineage, cell group, cell type	VWF IGFBP3 HMCN1 CD109 MERTK EPAS1	2.34e-06	200	85	6	b17eb1587ca86c3d40515128a00a8d8fd787fccf
ToppCell	LPS_anti-TNF-Endothelial-Endothelial-Artery\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	VWF IGFBP3 HMCN1 CD109 MERTK EPAS1	2.34e-06	200	85	6	b1ff8d61b567f85006d6d20093f9c803b6d34674
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	VWF ANGPT2 HMCN1 CLDN5 EPAS1 PLXNA2	2.34e-06	200	85	6	061ba851f941c616ddb462512e826c412881c3ce
ToppCell	facs-Lung-Endomucin-24m-Endothelial-Artery_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VWF CLDN5 NEB EPAS1 ZXDB	3.29e-06	119	85	5	c3f1223356e7f245a460ea5568a223e34e458dc1
ToppCell	ASK440-Endothelial-Endothelium\|Endothelial / Donor, Lineage and Cell class of Lung cells from Dropseq	SLC44A1 VWF IGFBP3 LAMP1 EPAS1	3.72e-06	122	85	5	2f76ec3b527e9528fbb006599a96e8bbdf9e0e62
ToppCell	Endothelial-B-IPF_01\|World / lung cells shred on cell class, cell subclass, sample id	RELN ANGPT2 ANK2 CHRDL1 CLDN5	1.66e-05	166	85	5	c286987ea4e511195607c87ec4529c2c2ed2122e
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CHRDL1 CNTN3 EPAS1 MCOLN3 EDNRA	1.87e-05	170	85	5	876b84740e15399bfff2b9c7f0b80fd759bbdb3f
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CHRDL1 CNTN3 EPAS1 MCOLN3 EDNRA	1.87e-05	170	85	5	1f8738acf439d893880db7e1fdc9b3615ca00c39
ToppCell	3'-Pediatric_IBD-SmallIntestine-Endothelial-lymphatic_endothelial-LEC4_(STAB2+)\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ZNF750 RELN VWF CHRDL1 CLDN5	1.97e-05	172	85	5	1bad7b19724e1b53ace7e05644215334c9f43910
ToppCell	ASK452-Immune-B_cell\|ASK452 / Donor, Lineage and Cell class of Lung cells from Dropseq	ZNF750 RELN PLXNA4 C4BPB BCL11A	2.09e-05	174	85	5	69723f5666abc3af5f0431901a60246c9915ef81
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical-aged\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CHRDL1 CNTN3 EPAS1 MCOLN3 EDNRA	2.14e-05	175	85	5	1b4cefae400bf756d09ece32d3f5c0bd4c6ad73f
ToppCell	facs-Lung-Endomucin-24m-Endothelial-Capillary_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VWF HMCN1 FOXP1 CLDN5 EPAS1	2.14e-05	175	85	5	1c7725f917f3d6b9e0a31ede9524690f408a5ea1
ToppCell	E16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	VWF IGFBP3 SLC18A2 CLDN5 EPAS1	2.20e-05	176	85	5	96779273b94345250cf53ba671203345b43d9e00
ToppCell	droplet-Liver-hepatocytes-3m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HMCN1 CLDN5 MAP3K12 EPAS1 ZMYM4	2.26e-05	177	85	5	8ef41ee5d63737b810ad7371b0437625e7e1badf
ToppCell	facs-Lung-Endomucin\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VWF HMCN1 FOXP1 CLDN5 EPAS1	2.33e-05	178	85	5	363e523233b1800a4c8e14c7b1a7814b8da29ccd
ToppCell	3'-GW_trimst-2-LargeIntestine-Endothelial-lymphatic_endothelial\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ZNF750 RELN VWF ANGPT2 CLDN5	2.39e-05	179	85	5	1c0c0647a111f691dae55f4ed8c51006059ce020
ToppCell	ASK452-Immune-B_cell\|Immune / Donor, Lineage and Cell class of Lung cells from Dropseq	ZNF750 RELN PLXNA4 C4BPB BCL11A	2.39e-05	179	85	5	c3cf49c069e66db16d2fce1de4c52a4c4fe7e832
ToppCell	ILEUM-non-inflamed-(7)_Lymphatics\|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	RELN ANGPT2 ANK2 CHRDL1 CLDN5	2.39e-05	179	85	5	99777a8931356d1206b8ab22aaa1b1d5a600b809
ToppCell	facs-Diaphragm-Limb_Muscle-24m-Endothelial\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VWF ANGPT2 PLXNA4 CLDN5 EPAS1	2.45e-05	180	85	5	f9b7d5eb7b6ea72253c89bdc351ad2b4a53f7d8e
ToppCell	facs-Diaphragm-Limb_Muscle-24m-Endothelial-endothelial_cell\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VWF ANGPT2 PLXNA4 CLDN5 EPAS1	2.45e-05	180	85	5	53db6032eda0e590ae7e01c9c3b472785ea6782f
ToppCell	facs-Diaphragm-Limb_Muscle-24m-Endothelial-nan\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VWF ANGPT2 PLXNA4 CLDN5 EPAS1	2.45e-05	180	85	5	28bc10b9d0e4430b952260014d8a6ff337860ac6
ToppCell	droplet-Lung-3m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l27\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	VWF PARG PLXNA4 CLDN5 EPAS1	2.52e-05	181	85	5	2c44c41b4e8a75ebdbaeb0c6cc5a03f17c44758c
ToppCell	5'-Adult-Appendix-Endothelial-lymphatic_endothelial-LEC6_(ADAMTS4+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RELN VWF ANGPT2 CHRDL1 CLDN5	2.59e-05	182	85	5	fd786c88826ad3d5cc5c3d80f8e392d6be1b5267
ToppCell	droplet-Pancreas-Exocrine-18m-Endothelial\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IGFBP3 HMCN1 CHRDL1 CLDN5 EPAS1	2.59e-05	182	85	5	3b4dbf61ca0fe50efe05449815630e301cb76630
ToppCell	droplet-Pancreas-Exocrine-18m-Endothelial-endothelial_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IGFBP3 HMCN1 CHRDL1 CLDN5 EPAS1	2.59e-05	182	85	5	ab5761bf9af439231cd0f487b6467e372672a517
ToppCell	PND14-Endothelial-Endothelial_blood-vessel-Macrovascular_EC\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	VWF HMCN1 FOXP1 CLDN5 EPAS1	2.66e-05	183	85	5	fc9a7ba148c22d0c8a46f6bc56c772929ac496f7
ToppCell	5'-Adult-Appendix-Endothelial-lymphatic_endothelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RELN VWF ANGPT2 CHRDL1 CLDN5	2.73e-05	184	85	5	453295362888c9a59d0e73c7a5b15914c50ff591
ToppCell	3'-GW_trimst-2-LargeIntestine-Endothelial-lymphatic_endothelial-LEC4_(STAB2+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ZNF750 RELN VWF ANGPT2 CLDN5	2.73e-05	184	85	5	3b0389c3a5a16697de860e98ebc48ed39ede646f
ToppCell	facs-Brain_Non-Myeloid-Cortex_-18m-Endothelial-endothelial_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VWF HMCN1 FOXP1 CLDN5 EPAS1	2.80e-05	185	85	5	7f46ea82a663181957f88e4e83114aef8a78820c
ToppCell	facs-Brain_Non-Myeloid-Cortex_-18m-Endothelial\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VWF HMCN1 FOXP1 CLDN5 EPAS1	2.80e-05	185	85	5	956fb0043c0c3e4e5c4d6f58ff95faf6209c380e
ToppCell	facs-Lung-Endomucin-3m-Endothelial\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DENND5B VWF FOXP1 CLDN5 EPAS1	2.80e-05	185	85	5	f262b441ea3fe7f69dff33d5f171000371f3a3e5
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_immature-Tip-like-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	VWF ANGPT2 HMCN1 CLDN5 EPAS1	2.87e-05	186	85	5	a906020a8df6fcca474b278f746c553b177a56b4
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts-Alveolar_fibroblasts_L.2.1.1.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ANK2 HMCN1 CHRDL1 COL6A5 EDNRA	2.87e-05	186	85	5	5473283fb95cee556b1f6934cf72169b676b5bcc
ToppCell	facs-Brain_Non-Myeloid-Cerebellum_-18m-Endothelial-Endothelial_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VWF HMCN1 FOXP1 CLDN5 EPAS1	2.87e-05	186	85	5	ba6ba75218efc26371cea24ddbb0e9b3e3f421ac
ToppCell	facs-Brain_Non-Myeloid-Cortex_-18m-Endothelial-Endothelial_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VWF HMCN1 FOXP1 CLDN5 EPAS1	2.87e-05	186	85	5	a58c9d1567da0961e0e295a156773d2252ee5a1a
ToppCell	facs-Brain_Non-Myeloid-Cerebellum_-18m-Endothelial\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VWF HMCN1 FOXP1 CLDN5 EPAS1	2.87e-05	186	85	5	65e25a9dcef5fc71510aaf170e220deef5b2feb2
ToppCell	Adult-Endothelial-endothelial_cell_of_artery\|Adult / Lineage, Cell type, age group and donor	VWF IGFBP3 HMCN1 CLDN5 EPAS1	2.87e-05	186	85	5	2d1c4ea2e401db89971582ee54618a8b0c81b8ac
ToppCell	facs-Brain_Non-Myeloid-Cerebellum_-18m-Endothelial-endothelial_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VWF HMCN1 FOXP1 CLDN5 EPAS1	2.87e-05	186	85	5	e4f1259725160719e5fd13d76e5a707efed70013
ToppCell	tumor_Lung-Endothelial_cells-Lymphatic_ECs\|tumor_Lung / Location, Cell class and cell subclass	RELN VWF ANGPT2 CLDN5 ZNF99	2.95e-05	187	85	5	87ecdc5f24aced95a37e653429f0fc493ff4aa3e
ToppCell	COVID-19-Heart-EC_2\|Heart / Disease (COVID-19 only), tissue and cell type	VWF ANGPT2 CLDN5 EPAS1 PLXNA2	2.95e-05	187	85	5	40ffc06a3e3251d9b12da390210d3e045af7537a
ToppCell	3'-GW_trimst-2-LargeIntestine-Endothelial-blood_vessel_EC-Fetal_arterial_EC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	VWF IGFBP3 CD109 CLDN5 EPAS1	2.95e-05	187	85	5	25efb82afe863a853ecdd781ad89026c993aaa67
ToppCell	Control-Endothelial_cells-Arterial_endothelial_cells\|Control / group, cell type (main and fine annotations)	VWF IGFBP3 CLDN5 EPAS1 PLXNA2	2.95e-05	187	85	5	81affaab3fe3e1daea45ada6445e906ddd33950e
ToppCell	P03-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_vein\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	DENND5B VWF HMCN1 FOXP1 EPAS1	3.02e-05	188	85	5	5eb107122064f0a99dfd445cc87d3766f7257216
ToppCell	facs-Heart-RA-3m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DENND5B VWF HMCN1 SLC18A2 FOXP1	3.02e-05	188	85	5	4ddb11a90bf3baa7237bde304db44dfcc56aed52
ToppCell	facs-Heart-RA-3m-Endothelial-endothelial_cell_of_endocardium\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DENND5B VWF HMCN1 SLC18A2 FOXP1	3.02e-05	188	85	5	e47e66906922d5c69b1aafe28face0787d3fc563
ToppCell	Adult-Endothelial-capillary_endothelial_cell_(Cap1)-D122\|Adult / Lineage, Cell type, age group and donor	VWF CD109 CLDN5 EPAS1 PLXNA2	3.02e-05	188	85	5	02a62888e9db29d20133eeca1686d302545a39c9
ToppCell	facs-Lung\|facs / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	VWF HMCN1 FOXP1 CLDN5 EPAS1	3.02e-05	188	85	5	f7292fc8e914f222828dcdb0a017d716207a97f6
ToppCell	facs-Lung\|facs / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VWF HMCN1 FOXP1 CLDN5 EPAS1	3.02e-05	188	85	5	e2b6e14579ec649a2bc106d9c99bb78ceb16ede3
ToppCell	5'-GW_trimst-2-LargeIntestine-Endothelial-blood_vessel_EC-Fetal_arterial_EC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	VWF IGFBP3 CD109 CLDN5 EPAS1	3.10e-05	189	85	5	db09d591b885ce2bc9e353f08b6694e2192582e1
ToppCell	Endothelial-endothelial_cell_of_artery\|World / Lineage, Cell type, age group and donor	VWF IGFBP3 HMCN1 CLDN5 EPAS1	3.10e-05	189	85	5	fdd89c71113ac99b7c800c6def8888e512ff1128
ToppCell	E16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	VWF IGFBP3 FOXP1 CLDN5 EPAS1	3.10e-05	189	85	5	feedac2751ed770f80bc56fec31662b5b3826f58
ToppCell	LPS-IL1RA+antiTNF-Endothelial-Endothelial-Artery\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	VWF HMCN1 CD109 CLDN5 MERTK	3.10e-05	189	85	5	c45734970036e6d28d5e3fe7c9458fae38a3f624
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	VWF CD109 CLDN5 EPAS1 PLXNA2	3.10e-05	189	85	5	6463890d8dbee4bc198f91628a5f784970de786a
ToppCell	RA-10._Endothelium_II\|World / Chamber and Cluster_Paper	VWF HMCN1 FOXP1 EPAS1 PLXNA2	3.10e-05	189	85	5	75c248b9de5e2fb7a0baa8cdbab516e575cc4394
ToppCell	RA-10._Endothelium_II\|RA / Chamber and Cluster_Paper	VWF HMCN1 FOXP1 EPAS1 PLXNA2	3.10e-05	189	85	5	c81787a8c662db5d7814c583dd64562857629e81
ToppCell	LPS_only-Endothelial-Endothelial-Artery\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	VWF HMCN1 CD109 CLDN5 MERTK	3.10e-05	189	85	5	b028466fcd36fdeceec752e55a24286a1cd62ae4
ToppCell	3'-GW_trimst-2-LargeIntestine-Endothelial-blood_vessel_EC-Fetal_venous_EC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	VWF HMCN1 CD109 CLDN5 EPAS1	3.10e-05	189	85	5	fccadf8efbef17b7f12291b069c71060a71b04e2
ToppCell	E17.5-Endothelial-large_vessel_endothelial_cell\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	VWF HMCN1 FOXP1 CLDN5 EPAS1	3.10e-05	189	85	5	360f09f46231a83f99d8fa0158b72a38068e1642
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_arterial-C\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	VWF ANGPT2 CLDN5 EPAS1 PLXNA2	3.18e-05	190	85	5	06bfb62b94b0faf467ef93d5bc5d08924c770098
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_artery\|Children_(3_yrs) / Lineage, Cell type, age group and donor	VWF IGFBP3 HMCN1 CLDN5 EPAS1	3.18e-05	190	85	5	f6c38d197fd9d69a4f97cb2e72cd4747984c1a86
ToppCell	Endothelial-A-Myositis-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	VWF ANGPT2 IGFBP3 CLDN5 EPAS1	3.26e-05	191	85	5	f702dfe88a9b04091dae87df61b2b4f43525f86a
ToppCell	PND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DENND5B VWF FOXP1 CLDN5 EPAS1	3.26e-05	191	85	5	0e8a73f01e3ec95d242c09231bcf3790324d0a67
ToppCell	nucseq-Endothelial-Endothelial_Vascular-Endothelial_large_blood_vessel-AEC\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	VWF IGFBP3 CLDN5 EPAS1 PLXNA2	3.26e-05	191	85	5	50601ef0a5a8f2c2120922989e08e85bf2d9b4ab
Disease	pulmonary hypertension (is_implicated_in)	VWF EPAS1 EDNRA	8.25e-05	30	83	3	DOID:6432 (is_implicated_in)
Disease	Stage IV Skin Melanoma	ADAM18 ADAM7	1.63e-04	7	83	2	C1321872
Disease	Malignant neoplasm of breast	NLRP14 ALKBH8 VWF ANK2 DKK1 CD109 NUP98 BCL11A TECTA CLSPN EDNRA	2.07e-04	1074	83	11	C0006142
Disease	atrial fibrillation (is_implicated_in)	VWF ANK2	6.96e-04	14	83	2	DOID:0060224 (is_implicated_in)
Disease	portal hypertension (implicated_via_orthology)	ANGPT2 EDNRA	1.30e-03	19	83	2	DOID:10762 (implicated_via_orthology)
Disease	bipolar disorder (is_marker_for)	RELN VWF	1.30e-03	19	83	2	DOID:3312 (is_marker_for)
Disease	schizophrenia (is_implicated_in)	FOXP1 CLDN5 BCL11A	1.40e-03	78	83	3	DOID:5419 (is_implicated_in)
Disease	level of Phosphatidylcholine (16:1_18:2) in blood serum	ROCK1 MYRF	1.59e-03	21	83	2	OBA_2045083
Disease	impotence (biomarker_via_orthology)	IGFBP3 EDNRA	1.74e-03	22	83	2	DOID:1875 (biomarker_via_orthology)
Disease	Down syndrome (is_marker_for)	RELN IGFBP3	1.74e-03	22	83	2	DOID:14250 (is_marker_for)
Disease	Hereditary Paraganglioma-Pheochromocytoma Syndrome	MERTK EPAS1	1.90e-03	23	83	2	C1708353
Disease	venous thromboembolism, tissue plasminogen activator measurement	VWF DGKZ	1.90e-03	23	83	2	EFO_0004286, EFO_0004791
Disease	venous thromboembolism	RELN VWF IGFBP3 ANK2 PLXNA4 DGKZ	1.91e-03	460	83	6	EFO_0004286
Disease	IGF-1 measurement	DENND5B IGFBP3 NUP98 DGKZ EPAS1 DOP1B	2.56e-03	488	83	6	EFO_0004627
Disease	S-warfarin measurement	ADAM7 OR4D1 CNTN3	2.62e-03	97	83	3	EFO_0803323
Disease	hearing impairment	CDK8 SLC17A8 TECTA	2.69e-03	98	83	3	C1384666

Protein segments in the cluster

Peptide	Gene	Start	Entry
SENMTKSHQNLCTKG	EPAS1	286	Q99814
MDSNHQSNYKLSKTE	ALKBH8	1	Q96BT7
ESHDICYKMNTKGNK	ADAM7	521	Q9H2U9
NKTCRKVHLMGYNCN	ADAM18	611	Q9Y3Q7
NKKTCVEYKHNEMTN	MASTL	461	Q96GX5
MDSIGKKQYQVQHGS	ANGPT2	26	O15123
CHQILDLYSQGKQQM	CCNK	251	O75909
YRGEQHKTCMLNATS	EDNRA	231	P25101
YNNHSEMSDLLKGKN	DCP2	301	Q8IU60
NYAKKCHQSEETMVS	BBS10	616	Q8TAM1
YNTISGHMLKTTKNN	DLGAP4	246	Q9Y2H0
VLKKNSISYAGCMTQ	OR8B8	86	Q15620
VTNLGVENMNHYKKT	PTPN9	431	P43378
KPLHYTTIMSNKVCN	OR6C65	126	A6NJZ3
CHYGNVKMVNFLLKQ	ANK2	736	Q01484
NISTKHQCITAMKEY	NUP98	181	P52948
SGLQKHYSNLCMEKS	LRRC34	51	Q8IZ02
HYSNLCMEKSQKINP	LRRC34	56	Q8IZ02
YENKGTKQSAMAICQ	MCOLN3	146	Q8TDD5
QRSDNGSYICKMKIN	MERTK	166	Q12866
QKYMLGTNHQLTVKS	DOP1B	216	Q9Y3R5
NYACAQSSKLTRHMK	BCL11A	776	Q9H165
TGKNLQKMVDSVYCN	FSIP2	4206	Q5CZC0
ECKPEFMTKSHQQYT	PLXNA2	936	O75051
QNKVHLYKCGAMRES	PLXNA4	796	Q9HCM2
KSTQYLNQHQTAAMC	PARG	141	Q86W56
IKNMQSSHAYCTPLN	FOXP1	556	Q9H334
SFCQSYDMKQHSTKV	MON2	371	Q7Z3U7
AKSLEKMGYNACTLH	DDX23	681	Q9BUQ8
YHSKEQQCVIMAENK	PLGLA	66	Q15195
CGQKYTPHMDNQVKL	RELN	936	P78509
NYTCIASNMEGKAQK	HMCN1	3221	Q96RW7
NCHLKNNVYVKSTTM	ITGB8	306	P26012
MNSKHLNGTITAKYT	CD109	241	Q6YHK3
KTEQVKHSETYCMFQ	CHRDL1	26	Q9BU40
QTCVVHYTGMLQNGK	FKBP1B	21	P68106
GAQKAMSDYHIQIKN	CFAP70	506	Q5T0N1
HSGSIKKQYQDHMIN	COL6A5	821	A8TX70
DKKNGNVCTNNISMY	DENND5B	431	Q6ZUT9
MCNDHYILKGSNRSQ	C4BPB	106	P20851
MIGKAYSTEHKQQQE	MAP3K12	101	Q12852
KKYRCVSGTQVHMNN	LAMP1	151	P11279
MYIHSQLKGKENACA	SLC44A1	461	Q8WWI5
KQAYHSKVSCFMLQQ	DGKZ	211	Q13574
NTYTNCSLIKYMEKH	CDK8	286	P49336
SKMYHTKGQEGSVCL	DKK1	176	O94907
NIQLKHSGKYVCMVQ	CNTN3	566	Q9P232
LHETKTISYQGCMAQ	OR4D1	86	Q15615
TTKGKEDVHCYSMQS	IGFBP3	276	P17936
EGNNKTVLKYKCHTM	GTF3C6	86	Q969F1
GQKMKYSIVSRNCEH	PLAAT4	101	Q9UL19
CSYSTSNKMKEGVNI	ITGAL	636	P20701
GTKTMAFHQQYLSCS	SERPINB11	111	Q96P15
VQSTGHMQCKVYDSV	CLDN5	56	O00501
CHGNAMALLKSSKYQ	CLSPN	326	Q9HAW4
HIQKMQGDGYCLKLT	TECTA	1681	O75443
FNHMKYGLCKNSITL	ZNF750	41	Q32MQ0
ECGKVFNNSSTLMKH	ZNF99	261	A8MXY4
CGKSFTTVYNLKAHM	ZXDB	341	P98169
VCESGMQTKHVYQNL	TNFSF8	176	P32971
QGKCASKAMYSIDIN	VWF	2751	P04275
CGSTYKNARGMQKHL	RLF	961	Q13129
NHCSVIQQKKMAQYL	PLCH2	421	O75038
KGKTSECSQYQQMLH	SS18	41	Q15532
SMHGQEKQEQSYKCN	ZNF267	256	Q14586
KYHALCSQTQVMEVG	ACP6	411	Q9NPH0
TQMCYASLDHSVKGK	TRAT1	106	Q6PIZ9
EGYSNTHKSKQMYCV	nan	46	A8MWL6
KKLTVTCSQNMNHEY	TRBV27	36	A0A0K0K1C4
QGHMKATQSYLQEKV	YLPM1	486	P49750
DSLVGTYSKIMNHKN	ROCK1	281	Q13464
NYKGMPLTCNKNLTH	ZNF677	116	Q86XU0
NLHYDQGCQTSRTKM	ZMYM2	816	Q9UBW7
TENMGQCKSLEYQHL	ZSWIM6	661	Q9HCJ5
QIKGQAMTYVQSHFC	UBR3	691	Q6ZT12
VNNAYGVQSSKCMHL	SEPSECS	251	Q9HD40
VSGPQYQHTKCMKSF	ZNF597	291	Q96LX8
HNCPIKTKMYTQNNI	SLC18A2	486	Q05940
QLQSYKSHGVMSKAC	TERB1	471	Q8NA31
HMLQIEGQSKKFCSS	ZMYM4	501	Q5VZL5
CGKAFNQKSILSMHQ	ZNF175	536	Q9Y473
MSYGATSQNCEVQKK	SLC17A8	546	Q8NDX2
HIYTKDGKQMSCNFI	ZRANB3	746	Q5FWF4
HNKNYNSFVSCNRKM	LRRCC1	366	Q9C099
QSTSYKDPHLTQMKC	NLRP14	516	Q86W24
CQKKNHFQVTVYIGM	MYRF	396	Q9Y2G1
THCMKVAAQNSDKSY	NEB	691	P20929