Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
MousePheno	increased basal cell carcinoma incidence	MSH6 PTCH1	3.23e-05	4	33	2	MP:0004208
Domain	Nucleotide-bd_a/b_plait	SAFB2 RBM12B RBM20 MCM3AP	1.82e-03	258	38	4	IPR012677
Domain	SH3	TJP2 PLCG1 NEB	9.55e-03	216	38	3	PS50002
Domain	SH3	TJP2 PLCG1 NEB	9.55e-03	216	38	3	SM00326
Domain	RRM	SAFB2 RBM12B RBM20	9.68e-03	217	38	3	SM00360
Domain	SH3_domain	TJP2 PLCG1 NEB	1.00e-02	220	38	3	IPR001452
Domain	RRM_dom	SAFB2 RBM12B RBM20	1.09e-02	227	38	3	IPR000504
Domain	RRM	SAFB2 RBM12B RBM20	1.13e-02	230	38	3	PS50102
Domain	EF_HAND_2	CACNA1B FLG PLCG1	1.15e-02	231	38	3	PS50222
Domain	EF_hand_dom	CACNA1B FLG PLCG1	1.16e-02	232	38	3	IPR002048
Domain	-	SAFB2 RBM12B RBM20	1.33e-02	244	38	3	3.30.70.330
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	SAFB2 TJP2 TJAP1 BUD13 MSH6 RICTOR GPATCH8 LMO7 ZC3H13	1.89e-07	774	40	9	15302935
Pubmed	Thin filament length in the cardiac sarcomere varies with sarcomere length but is independent of titin and nebulin.	NEB RBM20	1.29e-06	2	40	2	27139341
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	SAFB2 FLG BUD13 MSH6 GPATCH8 ZBED4 RBM12B WDR33 ZC3H13	3.03e-06	1082	40	9	38697112
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	SAFB2 TJP2 RICTOR PLCG1 GPATCH8 FN1 PTCH1 REPIN1 ZC3H13	3.08e-06	1084	40	9	11544199
Pubmed	Long non-coding RNA DBH-AS1 promotes cancer progression in diffuse large B-cell lymphoma by targeting FN1 via RNA-binding protein BUD13.	BUD13 FN1	3.87e-06	3	40	2	32091157
Pubmed	Reducing RBM20 activity improves diastolic dysfunction and cardiac atrophy.	NEB RBM20	3.87e-06	3	40	2	27889803
Pubmed	Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer.	TJP2 RICTOR LSR LMO7	5.88e-06	102	40	4	15778465
Pubmed	Altered neuregulin 1-erbB4 signaling contributes to NMDA receptor hypofunction in schizophrenia.	NRG1 PLCG1	2.70e-05	7	40	2	16767099
Pubmed	mTORC1-Mediated Inhibition of 4EBP1 Is Essential for Hedgehog Signaling-Driven Translation and Medulloblastoma.	RICTOR PTCH1	3.60e-05	8	40	2	29103956
Pubmed	JNK1/2-dependent phosphorylation of angulin-1/LSR is required for the exclusive localization of angulin-1/LSR and tricellulin at tricellular contacts in EpH4 epithelial sheet.	TJP2 LSR	3.60e-05	8	40	2	24889144
Pubmed	Essential roles of Meltrin beta (ADAM19) in heart development.	NRG1 FN1	3.60e-05	8	40	2	14975714
Pubmed	Hepatocyte nuclear factor 4 alpha is associated with mesenchymal-epithelial transition in developing kidneys of C57BL/6 mice.	TJP2 FN1	4.62e-05	9	40	2	21186337
Pubmed	An inducible CRISPR/Cas9 screen identifies DTX2 as a transcriptional regulator of human telomerase.	LSR RBM12B WDR33 MCM3AP	5.48e-05	180	40	4	35198878
Pubmed	Genetic analysis of the role of Alx4 in the coordination of lower body and external genitalia formation.	FN1 PTCH1	5.77e-05	10	40	2	23942202
Pubmed	Combined genetic-pharmacologic inactivation of tightly linked ADAMTS proteases in temporally specific windows uncovers distinct roles for versican proteolysis and glypican-6 in cardiac development.	FN1 PTCH1	7.05e-05	11	40	2	38750698
Pubmed	Action of Actomyosin Contraction With Shh Modulation Drive Epithelial Folding in the Circumvallate Papilla.	FN1 PTCH1	7.05e-05	11	40	2	32848868
Pubmed	SNX27-driven membrane localisation of OTULIN antagonises linear ubiquitination and NF-κB signalling activation.	TJP2 BUD13 RICTOR LMO7 ZC3H13	7.11e-05	378	40	5	34315543
Pubmed	The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1.	GPATCH8 REPIN1 ZC3H13 MCM3AP	7.78e-05	197	40	4	20811636
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	MSH6 RICTOR MSL1 PLCG1 GPATCH8 ZBED4 REPIN1 MCM3AP	1.14e-04	1327	40	8	32694731
Pubmed	The Hedgehog pathway promotes blood-brain barrier integrity and CNS immune quiescence.	FN1 PTCH1	1.16e-04	14	40	2	22144466
Pubmed	Pediatric Genetic Cholestatic Liver Disease Overview	TJP2 LSR	1.16e-04	14	40	2	36108118
Pubmed	E3 ubiquitin ligase SIAH1 mediates ubiquitination and degradation of TRB3.	FN1 MCM3AP	1.34e-04	15	40	2	18276110
Pubmed	Essential roles of fibronectin in the development of the left-right embryonic body plan.	FN1 PTCH1	1.34e-04	15	40	2	21466802
Pubmed	Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.	GPATCH8 RBM12B WDR33 RBM20 MCM3AP	1.73e-04	457	40	5	32344865
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	UBQLNL MSH6 FN1 ZBED4 ZC3H13 MCM3AP	1.83e-04	736	40	6	29676528
Pubmed	Cancer Stem Cells Regulate Cancer-Associated Fibroblasts via Activation of Hedgehog Signaling in Mammary Gland Tumors.	FN1 PTCH1	2.18e-04	19	40	2	28202523
Pubmed	Collagen VI suppresses fibronectin-induced enteric neural crest cell migration by downregulation of focal adhesion proteins.	NRG1 FN1	2.18e-04	19	40	2	29196262
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	PLCG1 PTCH1 ZBED4 DHX34 REPIN1 ANO8 MCM3AP	2.39e-04	1105	40	7	35748872
Pubmed	Hand2 loss-of-function in Hand1-expressing cells reveals distinct roles in epicardial and coronary vessel development.	NRG1 FN1	2.42e-04	20	40	2	21350214
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	TJP2 TJAP1 RICTOR LSR CBARP FN1	2.45e-04	777	40	6	35844135
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	TJP2 NRG1 NEB FN1 LMO7	2.54e-04	497	40	5	36774506
Pubmed	Epicardial function of canonical Wnt-, Hedgehog-, Fgfr1/2-, and Pdgfra-signalling.	FN1 PTCH1	2.94e-04	22	40	2	24000064
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	SAFB2 GPATCH8 RBM12B DHX34 WDR33 ZC3H13	3.00e-04	807	40	6	22681889
Pubmed	The DNA sequence and biology of human chromosome 19.	SAFB2 GFY LSR CBARP	3.16e-04	284	40	4	15057824
Pubmed	A novel role for cilia-dependent sonic hedgehog signaling during submandibular gland development.	NRG1 PTCH1	3.21e-04	23	40	2	29532549
Pubmed	Secreted metalloproteases ADAMTS9 and ADAMTS20 have a non-canonical role in ciliary vesicle growth during ciliogenesis.	FN1 PTCH1	3.21e-04	23	40	2	30814516
Pubmed	KSHV episome tethering sites on host chromosomes and regulation of latency-lytic switch by CHD4.	SAFB2 BUD13 WDR33	4.56e-04	130	40	3	35545047
Pubmed	The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.	NRG1 RICTOR LSR MSL1 CBARP	4.72e-04	569	40	5	30639242
Pubmed	Wnt7b stimulates embryonic lung growth by coordinately increasing the replication of epithelium and mesenchyme.	FN1 PTCH1	4.78e-04	28	40	2	18367557
Pubmed	Temporospatial sonic hedgehog signalling is essential for neural crest-dependent patterning of the intrinsic tongue musculature.	FN1 PTCH1	4.78e-04	28	40	2	31719045
Pubmed	The c-Ski family member and transcriptional regulator Corl2/Skor2 promotes early differentiation of cerebellar Purkinje cells.	PTCH1 SKOR2	4.78e-04	28	40	2	24491816
Pubmed	Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.	TJP2 PLCG1 ZC3H13	4.87e-04	133	40	3	15144186
Pubmed	Primary cilia and Gli3 activity regulate cerebral cortical size.	TJP2 PTCH1	5.13e-04	29	40	2	21976438
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	SAFB2 TJP2 BUD13 MSH6 RBM12B LMO7 ZC3H13	5.19e-04	1257	40	7	36526897
Pubmed	UBR-box containing protein, UBR5, is over-expressed in human lung adenocarcinoma and is a potential therapeutic target.	MSH6 RICTOR	5.50e-04	30	40	2	32867711
Pubmed	Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.	SAFB2 MSH6 GPATCH8 LMO7	5.68e-04	332	40	4	32786267
Pubmed	Wnt/β-catenin signaling maintains the mesenchymal precursor pool for murine sinus horn formation.	FN1 PTCH1	5.87e-04	31	40	2	21757651
Pubmed	Adamtsl2 deletion results in bronchial fibrillin microfibril accumulation and bronchial epithelial dysplasia--a novel mouse model providing insights into geleophysic dysplasia.	TJP2 FN1	5.87e-04	31	40	2	25762570
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	SAFB2 MSL1 GPATCH8 ZBED4 LMO7 WDR33 ZC3H13	6.17e-04	1294	40	7	30804502
Pubmed	Splicing Regulator p54nrb /Non-POU Domain-Containing Octamer-Binding Protein Enhances Carcinogenesis Through Oncogenic Isoform Switch of MYC Box-Dependent Interacting Protein 1 in Hepatocellular Carcinoma.	LMO7 REPIN1	6.26e-04	32	40	2	31815296
Pubmed	Semaphorin 3E/PlexinD1 signaling is required for cardiac ventricular compaction.	NRG1 FN1	6.26e-04	32	40	2	31434798
Pubmed	Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability.	TJP2 MSH6 RICTOR	6.52e-04	147	40	3	29576527
Pubmed	Lhx2 is a direct NF-κB target gene that promotes primary hair follicle placode down-growth.	FN1 PTCH1	6.66e-04	33	40	2	26952977
Pubmed	Wnt5a and Wnt11 regulate mammalian anterior-posterior axis elongation.	TJP2 FN1	7.49e-04	35	40	2	25813538
Pubmed	SR protein kinases promote splicing of nonconsensus introns.	TJP2 BUD13 LMO7 ZC3H13	7.77e-04	361	40	4	26167880
Pubmed	Cardiac-specific developmental and epigenetic functions of Jarid2 during embryonic development.	NRG1 FN1	7.93e-04	36	40	2	29891551
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	SAFB2 MSH6 RICTOR PLCG1 FN1 DHX34 MCM3AP	8.03e-04	1353	40	7	29467282
Pubmed	Morphogenesis of the mouse neural plate depends on distinct roles of cofilin 1 in apical and basal epithelial domains.	TJP2 FN1	8.37e-04	37	40	2	25742799
Pubmed	Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.	MSH6 RICTOR PLCG1 FN1	8.60e-04	371	40	4	25241761
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	TJP2 MSL1 FN1 LMO7 REPIN1 WDR33 MCM3AP	8.68e-04	1371	40	7	36244648
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	TJP2 MSH6 FN1 ZC3H13 MCM3AP	8.78e-04	653	40	5	22586326
Pubmed	Control of cardiac jelly dynamics by NOTCH1 and NRG1 defines the building plan for trabeculation.	NRG1 FN1	8.83e-04	38	40	2	29743679
Pubmed	Tbx2 controls lung growth by direct repression of the cell cycle inhibitor genes Cdkn1a and Cdkn1b.	FN1 PTCH1	9.30e-04	39	40	2	23341776
Pubmed	Global defects in collagen secretion in a Mia3/TANGO1 knockout mouse.	FN1 PTCH1	9.30e-04	39	40	2	21606205
Pubmed	YAP is essential for mechanical force production and epithelial cell proliferation during lung branching morphogenesis.	TJP2 PTCH1	9.79e-04	40	40	2	28323616
Pubmed	Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1.	SAFB2 DHX34	1.03e-03	41	40	2	8590280
Pubmed	Impact of WIN site inhibitor on the WDR5 interactome.	RICTOR MSL1	1.13e-03	43	40	2	33472061
Interaction	EZH1 interactions	SAFB2 TJP2 BUD13 ZC3H13	2.67e-05	92	38	4	int:EZH1
Interaction	CACNB3 interactions	CACNA1B CBARP PLCG1	2.95e-05	32	38	3	int:CACNB3
Interaction	LINC02910 interactions	SAFB2 TJP2 BUD13 ZC3H13	3.02e-05	95	38	4	int:LINC02910
Interaction	ANKRD50 interactions	SAFB2 TJP2 BUD13 ZC3H13	5.00e-05	108	38	4	int:ANKRD50
Interaction	TMSB4Y interactions	SAFB2 BUD13 ZC3H13	5.39e-05	39	38	3	int:TMSB4Y
Interaction	RDH11 interactions	NRG1 RICTOR FN1 PTCH1	7.55e-05	120	38	4	int:RDH11
Cytoband	Ensembl 112 genes in cytogenetic band chr19p13	SAFB2 CBARP RNF126 ZNF491 ANO8	6.20e-04	797	40	5	chr19p13
Cytoband	19p13.3	SAFB2 CBARP RNF126	1.17e-03	237	40	3	19p13.3
Cytoband	19q13.3	HRC DHX34	2.35e-03	82	40	2	19q13.3
GeneFamily	RNA binding motif containing	SAFB2 RBM12B RBM20	4.25e-03	213	28	3	725
GeneFamily	EF-hand domain containing	CACNA1B FLG PLCG1	4.59e-03	219	28	3	863
ToppCell	367C-Myeloid-Monocyte-CD16+_Monocyte\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	CBARP VPREB3 ACTL10 ANO8	1.40e-05	164	40	4	1aff83fc73b4e41e6f0d4b04dbca153bcc7a3518
ToppCell	367C-Myeloid-Monocyte-CD16+_Monocyte\|367C / Donor, Lineage, Cell class and subclass (all cells)	CBARP VPREB3 ACTL10 ANO8	1.47e-05	166	40	4	430d604f5bef9fae20dc81492e6695616f6701a3
ToppCell	367C-Myeloid-Monocyte-CD16+_Monocyte\|Monocyte / Donor, Lineage, Cell class and subclass (all cells)	CBARP VPREB3 ACTL10 ANO8	1.69e-05	172	40	4	fb8ab2576b5c38db63573a3bf46b8d9d634c4999
ToppCell	facs-Heart-LA-3m-Endothelial-endothelial_cell_of_endocardium\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NRG1 LSR SMPD3 FN1	2.60e-05	192	40	4	14a816ef116aa992f86edab411f043cf7d07fe04
ToppCell	facs-Heart-LA-3m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NRG1 LSR SMPD3 FN1	2.60e-05	192	40	4	847822514d747a21d5eb40e04ba9a023fd32bd65
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1B CBARP SMPD3 RTL1	2.77e-05	195	40	4	ffbab350e67d9c4b66c0ab84550daec8b8139a27
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-Pericyte-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	HRC FN1 RTL1 RBM20	2.88e-05	197	40	4	2872a78b1be61aa1d50bc9a49294a21e922dc033
ToppCell	10x3'2.3-week_14-16-Mesenchymal_osteo-stroma-early_osteoblast\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	SMPD3 FN1 PTCH1 LMO7	2.94e-05	198	40	4	6a539d3b47bd2d4a7ad5c67cad23facffc0ac45f
Drug	aristolactam	CACNA1B FN1	1.80e-05	4	40	2	CID000096710
Drug	Naltrexone hydrochloride dihydrate [16676-29-2]; Down 200; 9.6uM; PC3; HT_HG-U133A	TJAP1 PLCG1 FN1 ZBED4 LMO7	2.31e-05	196	40	5	5765_DN
Drug	Benoxinate hydrochloride [5987-82-6]; Up 200; 11.6uM; MCF7; HT_HG-U133A	TJAP1 NEB DHX34 WDR33 ZC3H13	2.43e-05	198	40	5	1476_UP
Drug	Pancuronium bromide [15500-66-0]; Up 200; 5.4uM; HL60; HT_HG-U133A	TJAP1 FN1 TRIM58 DHX34 ZC3H13	2.43e-05	198	40	5	2909_UP
Drug	Betulin [473-98-3]; Down 200; 9uM; MCF7; HT_HG-U133A	SAFB2 PLCG1 FN1 ZBED4 RNF126	2.49e-05	199	40	5	7454_DN
Drug	PTFE	LSR FN1 PTCH1	2.89e-05	34	40	3	CID000008301
Disease	creativity measurement	SAFB2 NRG1	7.22e-05	10	38	2	EFO_0010650
Disease	receptor-interacting serine/threonine-protein kinase 2 measurement	NRG1 LSR	8.82e-05	11	38	2	EFO_0802997
Disease	MAP kinase-activated protein kinase 3 measurement	NRG1 ZC3H13	1.25e-04	13	38	2	EFO_0008226
Disease	Movement Disorders	CACNA1B NRG1	6.41e-04	29	38	2	C0026650
Disease	primary ovarian insufficiency (implicated_via_orthology)	MSH6 WDR33	1.61e-03	46	38	2	DOID:5426 (implicated_via_orthology)
Disease	inflammatory biomarker measurement, YKL40 measurement	MSH6 PTCH1	1.98e-03	51	38	2	EFO_0004869, EFO_0004872
Disease	leukemia	MSH6 SMPD3	2.30e-03	55	38	2	C0023418

Protein segments in the cluster

Peptide	Gene	Start	Entry
HDPHFDDTPAAARHR	CBARP	556	Q8N350
DDTPAAARHRARAHP	CBARP	561	Q8N350
FEGDLRDPARHHPAS	ACTL10	91	Q5JWF8
EDLPSNRHFRHDTPD	BUD13	111	Q9BRD0
NRHFRHDTPDSSPRR	BUD13	116	Q9BRD0
DGSRHPRSHDEDRAS	FLG	331	P20930
AREERPRPHRSHSKE	CACNA1B	881	Q00975
RRDSERSHSPPKAFH	ANO8	1036	Q9HCE9
EEHSPPRGINDRHFR	RBM12B	251	Q8IXT5
DFRQPDRHPPEDFRH	RBM12B	546	Q8IXT5
DRHPPEDFRHSSEDF	RBM12B	551	Q8IXT5
PQEHFRRSREEDFRH	RBM12B	791	Q8IXT5
DEARLRESRHPHPDD	RBM20	786	Q5T481
RESRHPHPDDSGKED	RBM20	791	Q5T481
RHARETPDSYRDSPH	NRG1	406	Q02297
DQDRSPRRHGHEPAE	MCM3AP	296	O60318
GHESPEERHSGRRDF	GPATCH8	1011	Q9UKJ3
APPRHHKREDSFESL	LMO7	236	Q8WWI1
EHRRRPDHPDFDAST	MSH6	381	P52701
DEPGAAEAHFLPRHR	MSL1	36	Q68DK7
RRRRHPDEAFDHEVS	SMPD3	336	Q9NY59
PPHDDRGARAFAHDA	RICTOR	1451	Q6R327
RQRPFAHHRLPDDGD	GFY	436	I3L273
EHFSGRPREDRVPHS	FN1	1486	P02751
DRRDHHRAPSEEEAL	DHX34	11	Q14147
DQDDSRDFPRSRDPH	LSR	536	Q86X29
PAPKHFSGDRREFHE	RTL1	201	A6NKG5
DPHVPFHVRCERRDS	PTCH1	1411	Q13635
RDPESRRERDHPSRH	RNF126	106	Q9BV68
RRHPRAEPHSEDDSR	SAMD14	156	Q8IZD0
RDPSHRHRSHEEDDN	HRC	291	P23327
LAAHRRDHAPDRPFV	REPIN1	446	Q9BWE0
ELQRHFAHSPADRDE	TJAP1	441	Q5JTD0
DHDFGPSRDRDRDRS	TJP2	226	Q9UDY2
PRRDDFFRHESGEHF	FSBP	211	O95073
HLADHFDSRERRAPR	PLCG1	1266	P19174
PDHRFHDFDHRDRGQ	SAFB2	761	Q14151
HSFRDLPTNDPCHRD	UBQLNL	111	Q8IYU4
APHAHHKRPRFDDDD	SKOR2	301	Q2VWA4
YRSEEDHHRPADIPD	VPREB3	71	Q9UKI3
DHHRPADIPDRFSAA	VPREB3	76	Q9UKI3
RTHERPHTREKPFDC	ZNF491	91	Q8N8L2
PDDFHPDKRFGHRLR	WDR33	1016	Q9C0J8
SRDHLDPASDVRDDH	TRIM58	471	Q8NG06
SSSRDHRDDREPRDG	ZC3H13	441	Q5T200
VSFESPARPRCDDHH	ZBED4	751	O75132
PDRPEHFHHRAVTDT	NEB	5316	P20929