Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	endoplasmic reticulum membrane	SELENOT VMP1 ACSL4 PIGT SCAP CYP4A11 MTOR CYP4B1 TEX2 LPCAT3 CERS3 MMP27 RNF43 RYR1	2.39e-04	1293	77	14	GO:0005789
GeneOntologyCellularComponent	endoplasmic reticulum subcompartment	SELENOT VMP1 ACSL4 PIGT SCAP CYP4A11 MTOR CYP4B1 TEX2 LPCAT3 CERS3 MMP27 RNF43 RYR1	2.51e-04	1299	77	14	GO:0098827
GeneOntologyCellularComponent	nuclear outer membrane-endoplasmic reticulum membrane network	SELENOT VMP1 ACSL4 PIGT SCAP CYP4A11 MTOR CYP4B1 TEX2 LPCAT3 CERS3 MMP27 RNF43 RYR1	3.12e-04	1327	77	14	GO:0042175
GeneOntologyCellularComponent	TORC2 complex	MTOR RICTOR	4.74e-04	9	77	2	GO:0031932
GeneOntologyCellularComponent	TOR complex	MTOR RICTOR	8.63e-04	12	77	2	GO:0038201
Domain	MABP	DENND4A DENND4B	9.24e-05	4	74	2	IPR023341
Domain	MABP	DENND4A DENND4B	9.24e-05	4	74	2	PS51498
Domain	-	RELN NEU2	1.54e-04	5	74	2	2.120.10.10
Domain	PPR	DENND4A DENND4B	4.27e-04	8	74	2	PS51375
Domain	Sialidases	RELN NEU2	5.48e-04	9	74	2	IPR011040
Domain	TF_fork_head_CS_2	FOXD4L3 FOXD4L6 FOXD4L5	8.02e-04	46	74	3	IPR030456
Domain	TF_fork_head_CS_1	FOXD4L3 FOXD4L6 FOXD4L5	8.54e-04	47	74	3	IPR018122
Domain	FH	FOXD4L3 FOXD4L6 FOXD4L5	9.65e-04	49	74	3	SM00339
Domain	FORK_HEAD_1	FOXD4L3 FOXD4L6 FOXD4L5	9.65e-04	49	74	3	PS00657
Domain	FORK_HEAD_2	FOXD4L3 FOXD4L6 FOXD4L5	9.65e-04	49	74	3	PS00658
Domain	Fork_head_dom	FOXD4L3 FOXD4L6 FOXD4L5	9.65e-04	49	74	3	IPR001766
Domain	FORK_HEAD_3	FOXD4L3 FOXD4L6 FOXD4L5	9.65e-04	49	74	3	PS50039
Domain	Forkhead	FOXD4L3 FOXD4L6 FOXD4L5	9.65e-04	49	74	3	PF00250
Domain	uDENN	DENND4A DENND4B	1.37e-03	14	74	2	SM00800
Domain	uDENN	DENND4A DENND4B	1.57e-03	15	74	2	PF03456
Domain	HEAT	PIK3R4 MTOR TBCD	1.58e-03	58	74	3	IPR000357
Domain	UDENN	DENND4A DENND4B	1.79e-03	16	74	2	PS50946
Domain	DDENN	DENND4A DENND4B	1.79e-03	16	74	2	PS50947
Domain	DENN	DENND4A DENND4B	1.79e-03	16	74	2	SM00799
Domain	dDENN	DENND4A DENND4B	1.79e-03	16	74	2	SM00801
Domain	DENN	DENND4A DENND4B	1.79e-03	16	74	2	PF02141
Domain	dDENN_dom	DENND4A DENND4B	1.79e-03	16	74	2	IPR005112
Domain	uDENN_dom	DENND4A DENND4B	1.79e-03	16	74	2	IPR005113
Domain	dDENN	DENND4A DENND4B	1.79e-03	16	74	2	PF03455
Domain	DENN	DENND4A DENND4B	1.79e-03	16	74	2	PS50211
Domain	DENN_dom	DENND4A DENND4B	1.79e-03	16	74	2	IPR001194
Domain	-	PIK3R4 HGH1 MTOR RICTOR TBCD	1.88e-03	222	74	5	1.25.10.10
Domain	HEAT_REPEAT	PIK3R4 MTOR TBCD	2.70e-03	70	74	3	PS50077
Domain	Pentatricopeptide_repeat	DENND4A DENND4B	3.71e-03	23	74	2	IPR002885
Domain	ARM-like	PIK3R4 HGH1 MTOR RICTOR TBCD	4.35e-03	270	74	5	IPR011989
Domain	-	NCOR2 DPRX POU5F2 CERS3 DLX4	5.30e-03	283	74	5	1.10.10.60
Domain	AMP-binding	ACSL4 DIP2B	6.27e-03	30	74	2	PF00501
Domain	AMP-dep_Synth/Lig	ACSL4 DIP2B	6.27e-03	30	74	2	IPR000873
Pathway	REACTOME_METABOLISM_OF_LIPIDS	PIK3R4 ACSL4 NCOR2 NEU2 SCAP GAL3ST1 CYP4A11 CYP4B1 LPCAT3 CERS3 TNFAIP8L1	3.17e-05	620	57	11	MM15193
Pathway	REACTOME_METABOLISM_OF_LIPIDS	PIK3R4 ACSL4 NCOR2 NEU2 SCAP GAL3ST1 CYP4A11 CYP4B1 LPCAT3 CD36 CERS3 TNFAIP8L1	3.99e-05	757	57	12	M27451
Pathway	REACTOME_CD28_DEPENDENT_PI3K_AKT_SIGNALING	MTOR PDPK1 RICTOR	9.14e-05	22	57	3	M13897
Pathway	REACTOME_CD28_DEPENDENT_PI3K_AKT_SIGNALING	MTOR PDPK1 RICTOR	1.05e-04	23	57	3	MM14993
Pathway	WP_PPAR_SIGNALING	ACSL4 CYP4A11 PDPK1 CD36	1.52e-04	67	57	4	M39553
Pathway	REACTOME_CONSTITUTIVE_SIGNALING_BY_AKT1_E17K_IN_CANCER	MTOR PDPK1 RICTOR	1.53e-04	26	57	3	M27558
Pathway	KEGG_PPAR_SIGNALING_PATHWAY	ACSL4 CYP4A11 PDPK1 CD36	1.71e-04	69	57	4	M13088
Pathway	REACTOME_VEGFR2_MEDIATED_VASCULAR_PERMEABILITY	MTOR PDPK1 RICTOR	1.71e-04	27	57	3	M27422
Pathway	WP_PPAR_SIGNALING_PATHWAY	ACSL4 CYP4A11 PDPK1 CD36	2.12e-04	73	57	4	MM15995
Pathway	REACTOME_VEGFR2_MEDIATED_VASCULAR_PERMEABILITY	MTOR PDPK1 RICTOR	2.35e-04	30	57	3	MM15170
Pathway	REACTOME_CD28_CO_STIMULATION	MTOR PDPK1 RICTOR	3.14e-04	33	57	3	M11725
Pathway	REACTOME_CD28_CO_STIMULATION	MTOR PDPK1 RICTOR	3.43e-04	34	57	3	MM14992
Pathway	PID_PI3KCI_AKT_PATHWAY	MTOR PDPK1 RICTOR	3.74e-04	35	57	3	M249
Pathway	REACTOME_REGULATION_OF_TP53_DEGRADATION	MTOR PDPK1 RICTOR	4.07e-04	36	57	3	MM15339
Pathway	REACTOME_REGULATION_OF_TP53_EXPRESSION_AND_DEGRADATION	MTOR PDPK1 RICTOR	4.42e-04	37	57	3	M27641
Pathway	REACTOME_IRS_MEDIATED_SIGNALLING	PIK3R4 PDPK1 KLB	5.99e-04	41	57	3	MM14505
Pathway	PID_CXCR3_PATHWAY	MTOR PDPK1 RICTOR	6.90e-04	43	57	3	M222
Pathway	REACTOME_FREE_FATTY_ACIDS_REGULATE_INSULIN_SECRETION	ACSL4 CD36	8.63e-04	11	57	2	M27317
Pathway	REACTOME_FREE_FATTY_ACIDS_REGULATE_INSULIN_SECRETION	ACSL4 CD36	8.63e-04	11	57	2	MM15035
Pathway	REACTOME_SIGNALING_BY_TYPE_1_INSULIN_LIKE_GROWTH_FACTOR_1_RECEPTOR_IGF1R	PIK3R4 PDPK1 KLB	8.96e-04	47	57	3	MM14885
Pathway	REACTOME_IRS_MEDIATED_SIGNALLING	PIK3R4 PDPK1 KLB	9.53e-04	48	57	3	M26916
Pathway	REACTOME_INSULIN_RECEPTOR_SIGNALLING_CASCADE	PIK3R4 PDPK1 KLB	9.53e-04	48	57	3	MM15441
Pathway	REACTOME_PI3K_AKT_SIGNALING_IN_CANCER	MTOR PDPK1 RICTOR KLB	1.01e-03	110	57	4	M27162
Pathway	REACTOME_EICOSANOIDS	CYP4A11 CYP4B1	1.03e-03	12	57	2	M27129
Pathway	REACTOME_MISCELLANEOUS_SUBSTRATES	CYP4A11 CYP4B1	1.03e-03	12	57	2	M27128
Pathway	REACTOME_EICOSANOIDS	CYP4A11 CYP4B1	1.03e-03	12	57	2	MM14845
Pathway	KEGG_MTOR_SIGNALING_PATHWAY	MTOR PDPK1 RICTOR	1.20e-03	52	57	3	M7561
Pathway	REACTOME_SIGNALING_BY_TYPE_1_INSULIN_LIKE_GROWTH_FACTOR_1_RECEPTOR_IGF1R	PIK3R4 PDPK1 KLB	1.34e-03	54	57	3	M27168
Pathway	REACTOME_INSULIN_RECEPTOR_SIGNALLING_CASCADE	PIK3R4 PDPK1 KLB	1.34e-03	54	57	3	M620
Pathway	REACTOME_FATTY_ACIDS	CYP4A11 CYP4B1	1.63e-03	15	57	2	M27126
Pathway	KEGG_MEDICUS_REFERENCE_RELN_VLDLR_PI3K_SIGNALING_PATHWAY	RELN MTOR	1.63e-03	15	57	2	M47663
Pathway	WP_RIOK1_AND_RIOK2_IN_EGFR_AND_PI3KMEDIATED_TUMORIGENESIS	MTOR RICTOR	1.63e-03	15	57	2	M48306
Pathway	KEGG_MEDICUS_REFERENCE_AUTOPHAGY_VESICLE_NUCLEATION_ELONGATION_MATURATION_MTORC1_PI3KC3_C1	PIK3R4 MTOR	1.86e-03	16	57	2	M47457
Pubmed	Neural transcription factors bias cleavage stage blastomeres to give rise to neural ectoderm.	FOXD4L3 FOXD4L6 FOXD4L5	2.08e-07	6	77	3	27092474
Pubmed	Critical roles of mTORC1 signaling and metabolic reprogramming for M-CSF-mediated myelopoiesis.	SCAP MTOR RICTOR	2.08e-07	6	77	3	28784627
Pubmed	Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex.	MTOR PDPK1 RICTOR	3.63e-07	7	77	3	15718470
Pubmed	Mouse models of human PIK3CA-related brain overgrowth have acutely treatable epilepsy.	RELN MTOR PDPK1 RICTOR	5.06e-07	29	77	4	26633882
Pubmed	The mouse fkh-2 gene. Implications for notochord, foregut, and midbrain regionalization.	FOXD4L3 FOXD4L6 FOXD4L5	5.80e-07	8	77	3	8530406
Pubmed	An amphioxus winged helix/forkhead gene, AmphiFoxD: insights into vertebrate neural crest evolution.	FOXD4L3 FOXD4L6 FOXD4L5	8.68e-07	9	77	3	12412011
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	NCOR2 SCAP CELSR2 MTOR BICRA RBM19 FBRS LRP4 BABAM2 RNF43 RYR1 TBCD ZNF503	8.75e-07	1105	77	13	35748872
Pubmed	Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.	NCOR2 SCAP CYP4A11 MTOR CYP4B1 PDPK1 CD36	1.43e-06	250	77	7	18660489
Pubmed	mTORC1/2 signaling is downregulated by amino acid-free culture of mouse preimplantation embryos and is only partially restored by amino acid readdition.	MTOR PDPK1 RICTOR	1.70e-06	11	77	3	33052068
Pubmed	A genetic study of the suppressors of the Engrailed-1 cerebellar phenotype.	FOXD4L3 FOXD4L6 FOXD4L5	2.94e-06	13	77	3	16884697
Pubmed	Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending.	FOXD4L3 FOXD4L6 FOXD4L5	2.94e-06	13	77	3	7957066
Pubmed	Six members of the mouse forkhead gene family are developmentally regulated.	FOXD4L3 FOXD4L6 FOXD4L5	4.66e-06	15	77	3	7689224
Pubmed	Strain-specific modifier genes of Cecr2-associated exencephaly in mice: genetic analysis and identification of differentially expressed candidate genes.	FOXD4L3 FOXD4L6 FOXD4L5	4.66e-06	15	77	3	22045912
Pubmed	TOR complex 2 is needed for cell cycle progression and anchorage-independent growth of MCF7 and PC3 tumor cells.	MTOR RICTOR	4.84e-06	2	77	2	18831768
Pubmed	Rictor phosphorylation on the Thr-1135 site does not require mammalian target of rapamycin complex 2.	MTOR RICTOR	4.84e-06	2	77	2	20501647
Pubmed	TIPE1-mediated autophagy suppression promotes nasopharyngeal carcinoma cell proliferation via the AMPK/mTOR signalling pathway.	MTOR TNFAIP8L1	4.84e-06	2	77	2	32588529
Pubmed	Acyl-CoA synthetase-4, a new regulator of mTOR and a potential therapeutic target for enhanced estrogen receptor function in receptor-positive and -negative breast cancer.	ACSL4 MTOR	4.84e-06	2	77	2	26536660
Pubmed	Fat cell-specific ablation of rictor in mice impairs insulin-regulated fat cell and whole-body glucose and lipid metabolism.	MTOR RICTOR	4.84e-06	2	77	2	20332342
Pubmed	mTORC2 sustains thermogenesis via Akt-induced glucose uptake and glycolysis in brown adipose tissue.	MTOR RICTOR	4.84e-06	2	77	2	26772600
Pubmed	Adipocyte-specific mTORC2 deficiency impairs BAT and iWAT thermogenic capacity without affecting glucose uptake and energy expenditure in cold-acclimated mice.	MTOR RICTOR	4.84e-06	2	77	2	34541875
Pubmed	Involvement of Rictor/mTORC2 in cardiomyocyte differentiation of mouse embryonic stem cells in vitro.	MTOR RICTOR	4.84e-06	2	77	2	28123351
Pubmed	A carbazole alkaloid deactivates mTOR through the suppression of rictor and that induces apoptosis in lung cancer cells.	MTOR RICTOR	4.84e-06	2	77	2	25893736
Pubmed	Distinct roles of the mTOR components Rictor and Raptor in MO7e megakaryocytic cells.	MTOR RICTOR	4.84e-06	2	77	2	19341427
Pubmed	Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways.	MTOR RICTOR	4.84e-06	2	77	2	20620941
Pubmed	Targeting mTORC2 inhibits colon cancer cell proliferation in vitro and tumor formation in vivo.	MTOR RICTOR	4.84e-06	2	77	2	20226010
Pubmed	Conditional disruption of rictor demonstrates a direct requirement for mTORC2 in skin tumor development and continued growth of established tumors.	MTOR RICTOR	4.84e-06	2	77	2	25740823
Pubmed	MTOR signaling is essential for the development of thymic epithelial cells and the induction of central immune tolerance.	MTOR RICTOR	4.84e-06	2	77	2	29099279
Pubmed	Mammalian target of rapamycin complex 2 (mTORC2) coordinates pulmonary artery smooth muscle cell metabolism, proliferation, and survival in pulmonary arterial hypertension.	MTOR RICTOR	4.84e-06	2	77	2	24270265
Pubmed	mTOR complex 2 in adipose tissue negatively controls whole-body growth.	MTOR RICTOR	4.84e-06	2	77	2	19497867
Pubmed	Activation of mTORC2 by association with the ribosome.	MTOR RICTOR	4.84e-06	2	77	2	21376236
Pubmed	Glucose-dependent acetylation of Rictor promotes targeted cancer therapy resistance.	MTOR RICTOR	4.84e-06	2	77	2	26170313
Pubmed	Vital roles of mTOR complex 2 in Notch-driven thymocyte differentiation and leukemia.	MTOR RICTOR	4.84e-06	2	77	2	22473959
Pubmed	Methylation Regulation of LPCAT3 Improves Osteoarthritis by Regulating ACSL4 to Inhibit Chondrocyte Ferroptosis.	ACSL4 LPCAT3	4.84e-06	2	77	2	38073444
Pubmed	Rictor/mTORC2 pathway in oocytes regulates folliculogenesis, and its inactivation causes premature ovarian failure.	MTOR RICTOR	4.84e-06	2	77	2	25564616
Pubmed	Expression of the winged helix genes fkh-4 and fkh-5 defines domains in the central nervous system.	FOXD4L3 FOXD4L6 FOXD4L5	5.72e-06	16	77	3	8861101
Pubmed	Developmental competence of the gut endoderm: genetic potentiation by GATA and HNF3/fork head proteins.	FOXD4L3 FOXD4L6 FOXD4L5	5.72e-06	16	77	3	10208738
Pubmed	Functional equivalency between Otx2 and Otx1 in development of the rostral head.	FOXD4L3 FOXD4L6 FOXD4L5	9.86e-06	19	77	3	9895322
Pubmed	Forkhead transcription factor Foxf2 (LUN)-deficient mice exhibit abnormal development of secondary palate.	FOXD4L3 FOXD4L6 FOXD4L5	1.16e-05	20	77	3	12812790
Pubmed	Sequential roles for Otx2 in visceral endoderm and neuroectoderm for forebrain and midbrain induction and specification.	FOXD4L3 FOXD4L6 FOXD4L5	1.35e-05	21	77	3	9449667
Pubmed	PDK1 plays a vital role on hematopoietic stem cell function.	PDPK1 RICTOR	1.45e-05	3	77	2	28694518
Pubmed	Distribution and association of mTOR with its cofactors, raptor and rictor, in cumulus cells and oocytes during meiotic maturation in mice.	MTOR RICTOR	1.45e-05	3	77	2	23440873
Pubmed	Molecular cloning, structural analysis, and expression of a human IRLB, MYC promoter-binding protein: new DENN domain-containing protein family emerges.	DENND4A DENND4B	1.45e-05	3	77	2	12906859
Pubmed	Genome-wide shRNA screen reveals increased mitochondrial dependence upon mTORC2 addiction.	MTOR RICTOR	1.45e-05	3	77	2	21170086
Pubmed	mTOR kinase inhibitors promote antibody class switching via mTORC2 inhibition.	MTOR RICTOR	1.45e-05	3	77	2	25385646
Pubmed	Depletion of Rictor, an essential protein component of mTORC2, decreases male lifespan.	MTOR RICTOR	1.45e-05	3	77	2	25059582
Pubmed	Expression of the mTOR pathway regulators in human pituitary adenomas indicates the clinical course.	MTOR RICTOR	1.45e-05	3	77	2	23898069
Pubmed	mTOR has a developmental stage-specific role in mitochondrial fitness independent of conventional mTORC1 and mTORC2 and the kinase activity.	MTOR RICTOR	1.45e-05	3	77	2	28813526
Pubmed	Enhancing Acsl4 in absence of mTORC2/Rictor drove β-cell dedifferentiation via inhibiting FoxO1 and promoting ROS production.	ACSL4 RICTOR	1.45e-05	3	77	2	34455055
Pubmed	Myopathy caused by mammalian target of rapamycin complex 1 (mTORC1) inactivation is not reversed by restoring mitochondrial function.	MTOR RICTOR	1.45e-05	3	77	2	22143799
Pubmed	Involvement of mTORC1 and mTORC2 in regulation of glioblastoma multiforme growth and motility.	MTOR RICTOR	1.45e-05	3	77	2	19724909
Pubmed	The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2.	MTOR RICTOR	1.45e-05	3	77	2	21358638
Pubmed	Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy.	MTOR RICTOR	1.45e-05	3	77	2	20008564
Pubmed	Epithelial-mesenchymal reprogramming by KLF4-regulated Rictor expression contributes to metastasis of non-small cell lung cancer cells.	MTOR RICTOR	1.45e-05	3	77	2	35982899
Pubmed	Fibroblast growth factor 21 improves hepatic insulin sensitivity by inhibiting mammalian target of rapamycin complex 1 in mice.	MTOR KLB	1.45e-05	3	77	2	26926384
Pubmed	Cytoplasmic and nuclear distribution of the protein complexes mTORC1 and mTORC2: rapamycin triggers dephosphorylation and delocalization of the mTORC2 components rictor and sin1.	MTOR RICTOR	1.45e-05	3	77	2	18614546
Pubmed	Critical roles of mTOR Complex 1 and 2 for T follicular helper cell differentiation and germinal center responses.	MTOR RICTOR	1.45e-05	3	77	2	27690224
Pubmed	Deletion of Rictor in neural progenitor cells reveals contributions of mTORC2 signaling to tuberous sclerosis complex.	MTOR RICTOR	1.45e-05	3	77	2	23049074
Pubmed	Basal mTORC2 activity and expression of its components display diurnal variation in mouse perivascular adipose tissue.	MTOR RICTOR	1.45e-05	3	77	2	27016480
Pubmed	mTORC2 signalling regulates M2 macrophage differentiation in response to helminth infection and adaptive thermogenesis.	MTOR RICTOR	1.45e-05	3	77	2	28128208
Pubmed	Rictor regulates FBXW7-dependent c-Myc and cyclin E degradation in colorectal cancer cells.	MTOR RICTOR	1.45e-05	3	77	2	22285861
Pubmed	mTOR complex-2 activates ENaC by phosphorylating SGK1.	MTOR RICTOR	1.45e-05	3	77	2	20338997
Pubmed	Cardiac mTOR complex 2 preserves ventricular function in pressure-overload hypertrophy.	MTOR RICTOR	1.45e-05	3	77	2	26598511
Pubmed	mTOR complex component Rictor interacts with PKCzeta and regulates cancer cell metastasis.	MTOR RICTOR	1.45e-05	3	77	2	20978191
Pubmed	Langerhans cell homeostasis in mice is dependent on mTORC1 but not mTORC2 function.	MTOR RICTOR	1.45e-05	3	77	2	23212520
Pubmed	mTORC1 maintains renal tubular homeostasis and is essential in response to ischemic stress.	MTOR RICTOR	1.45e-05	3	77	2	24958889
Pubmed	TELO2 induced progression of colorectal cancer by binding with RICTOR through mTORC2.	MTOR RICTOR	1.45e-05	3	77	2	33416177
Pubmed	MicroRNA-let-7a regulates cell autophagy by targeting Rictor in gastric cancer cell lines MGC-803 and SGC-7901.	MTOR RICTOR	1.45e-05	3	77	2	29328491
Pubmed	mTOR phosphorylated at S2448 binds to raptor and rictor.	MTOR RICTOR	1.45e-05	3	77	2	19145465
Pubmed	Morin Acts as a USP7 Inhibitor to Hold Back the Migration of Rheumatoid Arthritis Fibroblast-Like Synoviocytes in a "Prickle1-mTORC2" Dependent Manner.	MTOR RICTOR	1.45e-05	3	77	2	34331380
Pubmed	ER phospholipid composition modulates lipogenesis during feeding and in obesity.	SCAP LPCAT3	1.45e-05	3	77	2	28846071
Pubmed	T-cell-specific mTOR deletion in mice ameliorated CD4+ T-cell survival in lethal sepsis induced by severe invasive candidiasis.	MTOR RICTOR	1.45e-05	3	77	2	31668132
Pubmed	A novel murine P-450 gene, Cyp4a14, is part of a cluster of Cyp4a and Cyp4b, but not of CYP4F, genes in mouse and humans.	CYP4A11 CYP4B1	1.45e-05	3	77	2	9271096
Pubmed	Crucial roles of Foxa2 in mouse anterior-posterior axis polarization via regulation of anterior visceral endoderm-specific genes.	FOXD4L3 FOXD4L6 FOXD4L5	1.56e-05	22	77	3	17389379
Pubmed	C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.	PIK3R4 VMP1 ACSL4 PIGT DENND4A SCAP TEX2 LPCAT3	1.61e-05	504	77	8	34432599
Pubmed	Otx2 is required to respond to signals from anterior neural ridge for forebrain specification.	FOXD4L3 FOXD4L6 FOXD4L5	2.04e-05	24	77	3	11820816
Pubmed	A Requirement for Zic2 in the Regulation of Nodal Expression Underlies the Establishment of Left-Sided Identity.	FOXD4L3 FOXD4L6 FOXD4L5	2.04e-05	24	77	3	29992973
Pubmed	Ssdp1 regulates head morphogenesis of mouse embryos by activating the Lim1-Ldb1 complex.	FOXD4L3 FOXD4L6 FOXD4L5	2.62e-05	26	77	3	15857913
Pubmed	Post-translational modifications regulate distinct functions of CARMA1 and BCL10.	PDPK1 RIPK2	2.89e-05	4	77	2	17468049
Pubmed	RBM45 reprograms lipid metabolism promoting hepatocellular carcinoma via Rictor and ACSL1/ACSL4.	ACSL4 RICTOR	2.89e-05	4	77	2	38040804
Pubmed	mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s.	MTOR RICTOR	2.89e-05	4	77	2	16919458
Pubmed	Rapamycin inhibits F-actin reorganization and phosphorylation of focal adhesion proteins.	MTOR RICTOR	2.89e-05	4	77	2	18504440
Pubmed	Interaction between NBS1 and the mTOR/Rictor/SIN1 complex through specific domains.	MTOR RICTOR	2.89e-05	4	77	2	23762398
Pubmed	mTORC1-independent autophagy regulates receptor tyrosine kinase phosphorylation in colorectal cancer cells via an mTORC2-mediated mechanism.	MTOR RICTOR	2.89e-05	4	77	2	28475179
Pubmed	mTOR disruption causes intestinal epithelial cell defects and intestinal atrophy postinjury in mice.	MTOR RICTOR	2.89e-05	4	77	2	26631481
Pubmed	Regulatory effects of mTORC2 complexes in type I IFN signaling and in the generation of IFN responses.	MTOR RICTOR	2.89e-05	4	77	2	22550181
Pubmed	Polyphyllin I induces autophagy and cell cycle arrest via inhibiting PDK1/Akt/mTOR signal and downregulating cyclin B1 in human gastric carcinoma HGC-27 cells.	MTOR PDPK1	2.89e-05	4	77	2	31387191
Pubmed	Ribavirin enhances interferon signaling via stimulation of mTOR and p53 activities.	MTOR RICTOR	2.89e-05	4	77	2	19619545
Pubmed	mTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes.	MTOR RICTOR	2.89e-05	4	77	2	16221682
Pubmed	Mammalian target of rapamycin and Rictor control neutrophil chemotaxis by regulating Rac/Cdc42 activity and the actin cytoskeleton.	MTOR RICTOR	2.89e-05	4	77	2	24006489
Pubmed	Interferon γ (IFNγ) Signaling via Mechanistic Target of Rapamycin Complex 2 (mTORC2) and Regulatory Effects in the Generation of Type II Interferon Biological Responses.	MTOR RICTOR	2.89e-05	4	77	2	26645692
Pubmed	Loss of mTOR signaling affects cone function, cone structure and expression of cone specific proteins without affecting cone survival.	MTOR RICTOR	2.89e-05	4	77	2	25887293
Pubmed	Phosphoinositide-dependent kinase 1 and mTORC2 synergistically maintain postnatal heart growth and heart function in mice.	PDPK1 RICTOR	2.89e-05	4	77	2	24662050
Pubmed	Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB.	MTOR RICTOR	2.89e-05	4	77	2	16603397
Pubmed	Therapeutic inhibition of mTORC2 rescues the behavioral and neurophysiological abnormalities associated with Pten-deficiency.	MTOR RICTOR	2.89e-05	4	77	2	31636454
Pubmed	Phospholipase D stabilizes HDM2 through an mTORC2/SGK1 pathway.	MTOR RICTOR	2.89e-05	4	77	2	20438709
Pubmed	Quantitative phosphoproteomics reveal mTORC1 activates de novo pyrimidine synthesis.	MTOR RICTOR	2.89e-05	4	77	2	23429704
Pubmed	A20 interacts with mTORC2 to inhibit the mTORC2/Akt/Rac1 signaling axis in hepatocellular carcinoma cells.	MTOR RICTOR	2.89e-05	4	77	2	36411371
Pubmed	Role of mTOR in podocyte function and diabetic nephropathy in humans and mice.	MTOR RICTOR	2.89e-05	4	77	2	21606591
Pubmed	CMPK1 and RBP3 are associated with corneal curvature in Asian populations.	MTOR RBP3	2.89e-05	4	77	2	24963161
Pubmed	TGF-β-induced activation of mTOR complex 2 drives epithelial-mesenchymal transition and cell invasion.	MTOR RICTOR	2.89e-05	4	77	2	22399812
Cytoband	9q21.11	FOXD4L3 FOXD4L6 FOXD4L5	1.78e-05	30	77	3	9q21.11
GeneFamily	MTOR complex 1\|MTOR complex 2	MTOR RICTOR	6.03e-05	5	45	2	1333
GeneFamily	Guanylate cyclase receptors\|DENN/MADD domain containing	DENND4A DENND4B	1.75e-03	25	45	2	504
GeneFamily	Cytochrome P450 family 4	CYP4A11 CYP4B1	3.62e-03	36	45	2	1003
GeneFamily	WD repeat domain containing	PIK3R4 SCAP WDR20 WDTC1	4.03e-03	262	45	4	362
ToppCell	LPS_IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT2\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	CYP4B1 PKHD1 USP54 DSEL RNF43	2.34e-05	197	77	5	b94645d57efe8d9e032bffb8c89af1f425c6421e
ToppCell	Control_saline-Epithelial_alveolar-AT_2\|Control_saline / Treatment groups by lineage, cell group, cell type	ACSL4 CYP4B1 CD36 USP54 RNF43	2.34e-05	197	77	5	b8f62fcd6eb8f47b3cc41f616126f82c68a36e87
ToppCell	LPS_only-Epithelial_alveolar\|LPS_only / Treatment groups by lineage, cell group, cell type	ACSL4 CYP4B1 USP54 DSEL RNF43	2.40e-05	198	77	5	655df75b9692d815c7f6910275e1f684ac63bf62
ToppCell	mild-HLA-DR-_S100A+_Monocyte\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	VMP1 CSRNP1 SLC11A1 CD36 ZNF503	2.46e-05	199	77	5	d0d286eafe935f9b3aaba5b783e8911251121b4a
ToppCell	LPS_IL1RA_TNF-Epithelial_alveolar-AT_1\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	CYP4B1 PKHD1 USP54 DSEL RNF43	2.46e-05	199	77	5	1c70e7d6bd25980e1b92aa1cac3f3c95d9651b4b
ToppCell	LPS_IL1RA-Epithelial_alveolar-AT_1\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	CYP4B1 PKHD1 USP54 DSEL RNF43	2.46e-05	199	77	5	a270630626df614f8605abddb7dee7c4d74f6149
ToppCell	LPS_IL1RA_TNF-Epithelial_alveolar\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	ACSL4 CYP4B1 USP54 DSEL RNF43	2.52e-05	200	77	5	c89f3cb36bb14c476d6a392bfd3ded1c8feecfeb
ToppCell	LPS_IL1RA_TNF-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	CYP4B1 PKHD1 USP54 DSEL RNF43	2.52e-05	200	77	5	ddfb1f006365bf16203ee49f20200f68220cc288
ToppCell	LPS_only-Epithelial_alveolar-AT_1\|LPS_only / Treatment groups by lineage, cell group, cell type	CYP4B1 PKHD1 USP54 DSEL RNF43	2.52e-05	200	77	5	9a6ae40f3e17cd44ee5fd73260713b920aa2ea15
Disease	urate measurement	TMEM11 VMP1 ANKRD33 SLC52A1 WDR20 MACROD1 PKHD1 LRP4 BABAM2 KLB	6.13e-05	895	72	10	EFO_0004531
Disease	10-undecenoate 11:1n1 measurement	CYP4A11 CYP4B1	1.22e-04	7	72	2	EFO_0021099
Disease	X-18899 measurement	CYP4A11 CYP4B1	1.22e-04	7	72	2	EFO_0800793
Disease	X-24748 measurement	CYP4A11 CYP4B1	1.63e-04	8	72	2	EFO_0022136
Disease	pimeloylcarnitine/3-methyladipoylcarnitine (C7-DC) measurement	CYP4A11 CYP4B1	1.63e-04	8	72	2	EFO_0800494
Disease	anemia (phenotype)	VMP1 RNF43	1.63e-04	8	72	2	EFO_0004272
Disease	intraocular pressure measurement	RELN MTOR PKHD1 LRP4 DSEL BABAM2 TNXB	2.44e-04	509	72	7	EFO_0004695
Disease	autosomal recessive polycystic kidney disease (biomarker_via_orthology)	CYP4A11 PKHD1	3.18e-04	11	72	2	DOID:0110861 (biomarker_via_orthology)
Disease	undecenoylcarnitine (C11:1) measurement	CYP4A11 CYP4B1	4.50e-04	13	72	2	EFO_0800588
Disease	Malformations of Cortical Development	MTOR TBCD	5.24e-04	14	72	2	C1955869
Disease	Cortical Dysplasia	MTOR TBCD	5.24e-04	14	72	2	C0431380
Disease	myocardial infarction (implicated_via_orthology)	MTOR CD36 RYR1	5.71e-04	66	72	3	DOID:5844 (implicated_via_orthology)
Disease	autosomal recessive polycystic kidney disease (implicated_via_orthology)	MTOR PKHD1	6.89e-04	16	72	2	DOID:0110861 (implicated_via_orthology)
Disease	alcohol use disorder (implicated_via_orthology)	PDPK1 FBRS ZNF683 RYR1	1.34e-03	195	72	4	DOID:1574 (implicated_via_orthology)
Disease	Liver carcinoma	ACSL4 CSRNP1 SCAP CYP4A11 MTOR SLC26A6	1.50e-03	507	72	6	C2239176
Disease	osteoarthritis (is_implicated_in)	NCOR2 CD36	2.13e-03	28	72	2	DOID:8398 (is_implicated_in)
Disease	lung small cell carcinoma (is_implicated_in)	MTOR RICTOR	2.13e-03	28	72	2	DOID:5409 (is_implicated_in)
Disease	Child Development Disorders, Specific	MSL3 TBCD	2.28e-03	29	72	2	C0085997
Disease	Child Development Deviations	MSL3 TBCD	2.28e-03	29	72	2	C0085996

Protein segments in the cluster

Peptide	Gene	Start	Entry
GPYLLIYPQLHLVRT	C2orf16	1141	Q68DN1
PKDTYIGYLPLAHVL	ACSL4	311	O60488
HYNALYGLGLLLTPP	CALHM3	46	Q86XJ0
LTPAFHYDILKPYVG	CYP4A11	146	Q02928
PLHLAIAYGCYPVLS	ANKRD61	171	A6NGH8
IYRTLAGLLPHNYDP	CELSR2	2251	Q9HCU4
ALAVYIHPYPNNILS	CC2D2B	1411	Q6DHV5
ASPNLSYSRPYGHLL	DLX4	41	Q92988
FLYRYSISGPHVLPI	DENND4A	331	Q7Z401
LFSKYGPLSELHYPI	RBM19	421	Q9Y4C8
GHVPLVSLLLNYYVG	ANKRD33	176	Q7Z3H0
GAHLLSVSLYYGPLL	OR5H8	241	P0DN80
ADALHTLRNYLPPVY	MSGN1	141	A6NI15
IRGYAVLPDYPKSIH	MMP27	351	Q9H306
IPLDAAAAYYLPRHL	NCOR2	1641	Q9Y618
HPSLSYEPALLQPYL	PTPRN	196	Q16849
YPYVGILHVRDSLIP	LEMD2	436	Q8NC56
ELLQALPDYSLGPHY	CSRNP1	506	Q96S65
HPLRYLLLSAPVYAG	FOXD4L3	266	Q6VB84
GVVLPTPLLLRHYHY	OR51L1	156	Q8NGJ5
QLPLGFLYVHHTYVP	PGLYRP2	401	Q96PD5
HLAFLSGLPALYYVA	FAM205A	781	Q6ZU69
HLAFLSGLPALYYVA	FAM205BP	511	Q63HN1
PPSYIYGAQHLLRLF	MSL3	446	Q8N5Y2
LLYPPGIELIAAFYG	DIP2B	1051	Q9P265
LGLPVDIPHYTRLYS	POU5F2	296	Q8N7G0
LGLFYLVGYTLLSPH	LPCAT3	236	Q6P1A2
LYFVVSYLPSLPHPA	SLC11A1	481	P49279
LPFLYVLLPAVYSGI	NPBWR2	41	P48146
LQRPHVYLPIHLYGQ	RICTOR	871	Q6R327
YTGHRVPSFQLILYP	DPRX	121	A6NFQ7
LISLHIAGNPTYYVP	RELN	56	P78509
APRLYYPLLLEHTLG	PRR35	261	P0CG20
GAHAYRIPALLYLPG	NEU2	16	Q9Y3R4
LLLVYSYAVPPLHAG	GAL3ST1	26	Q99999
PSHLYVTIPYAFLLL	CERS3	36	Q8IU89
YGLEPAHPLLYSRLA	FBRS	396	Q9HAH7
YPKLYLSPRIEHALG	BABAM2	216	Q9NXR7
CNLLTLYPYGDPHVI	C16orf96	991	A6NNT2
GRPVYISLPHFLYAS	CD36	336	P16671
YRLPAKYVIHTVGPI	MACROD1	216	Q9BQ69
FLYRYSVSGPHRLPL	DENND4B	336	O75064
LYYPTHAHLGLPEPL	KLB	641	Q86Z14
LTPGFHYDVLKPYVA	CYP4B1	141	P13584
LHRLLPYHVYQGALP	BICRA	1111	Q9NZM4
PVEILPFLYLGSAYH	DUSP4	196	Q13115
YHAALPMLIYGSLPI	SLC22A13	476	Q9Y226
YNHGLLCASYPIPII	SCAP	16	Q12770
HLPGPLRAGYYDLLI	RYR1	1701	P21817
HLVYYPSARPVLSLS	DSEL	991	Q8IZU8
GYNARAPLHYLAPLL	HGH1	166	Q9BTY7
LTDIGRYHPQALIYP	MTOR	1961	P42345
GIRNLIFYELPTYPH	UTP25	681	Q68CQ4
YLPQPIYRHIASFLS	SELENOT	76	P62341
HLIYDLDVAPYIGLP	TRNT1	256	Q96Q11
YALLAGLPPVFGLYS	SLC26A6	111	Q9BXS9
LLLTEGPHLYYVDPV	PDPK1	476	O15530
HPLRYLLLSAPVYAG	FOXD4L5	266	Q5VV16
HPLRYLLLSAPVYAG	FOXD4L6	266	Q3SYB3
YHLPAAYLLGPSRSA	RNF43	351	Q68DV7
LGFYPSITHRTIPYL	MT-ND5	526	P03915
EGLYKLLPHSEYSRP	WDR20	21	Q8TBZ3
RDLAPGPHYLSVFYT	PKHD1	1541	P08F94
PHRVYTPLALGLGLY	PROB1	926	E7EW31
INIYPEYILPGIAHL	PIK3R4	456	Q99570
AAQYYVAGHLPVKLP	WDTC1	246	Q8N5D0
PLALPLDYSHYISLP	TMEM11	96	P17152
PYIISYLHPGNTILH	RBP3	181	P10745
LLYNTHPYRAFPVLL	PIGT	371	Q969N2
LPYGRLAYHLAVVLG	SLC52A1	306	Q9NWF4
PTIPYHKLADLRYLS	RIPK2	11	O43353
VPGLDPAHRYKLLLY	TNXB	1831	P22105
QLYLLGSYNALPPLH	THNSL1	691	Q8IYQ7
ALKSGYPLVYPTHPL	ZNF503	461	Q96F45
QLLGLPTYRYHVLLG	TBCD	971	Q9BTW9
YLILPLPHYVSGLFL	TEX2	486	Q8IWB9
LAALYGPAEPYRSHL	TNFAIP8L1	156	Q8WVP5
PFLLHAFYPGYPLLL	ZNF683	186	Q8IZ20
HYQPLLLLYADPQGT	USP54	341	Q70EL1
LYLGPHIASVTLAAY	VMP1	136	Q96GC9
PVQHPYGLTLLDSYI	LRP4	1251	O75096