Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiondolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity

ALG10 ALG10B

1.21e-052702GO:0106073
GeneOntologyMolecularFunctionlipopolysaccharide immune receptor activity

SCARB1 TLR4

1.80e-046702GO:0001875
GeneOntologyMolecularFunctionpattern recognition receptor activity

SCARB1 TLR4 TLR9

2.49e-0435703GO:0038187
GeneOntologyBiologicalProcessdevelopmental process involved in reproduction

GMCL1 GMCL2 MSH6 PATZ1 WNT5A CSNK2A2 KAT8 TTC12 RXFP2 GATA4 AHR PAQR5 TLR9 CSMD1 CLOCK

1.11e-0512356915GO:0003006
GeneOntologyBiologicalProcesscolumnar/cuboidal epithelial cell differentiation

WNT5A GATA2 GATA4 EXT1 TLR9 CLOCK

1.83e-05164696GO:0002065
GeneOntologyBiologicalProcessdetection of molecule of bacterial origin

SCARB1 TLR4 TLR9

1.94e-0516693GO:0032490
GeneOntologyBiologicalProcessmale gonad development

PATZ1 WNT5A RXFP2 GATA4 TLR9 CSMD1

2.31e-05171696GO:0008584
GeneOntologyBiologicalProcessdevelopment of primary male sexual characteristics

PATZ1 WNT5A RXFP2 GATA4 TLR9 CSMD1

2.39e-05172696GO:0046546
GeneOntologyBiologicalProcessgonad development

PATZ1 WNT5A RXFP2 GATA4 AHR TLR9 CSMD1

5.40e-05292697GO:0008406
GeneOntologyBiologicalProcessmale sex differentiation

PATZ1 WNT5A RXFP2 GATA4 TLR9 CSMD1

5.41e-05199696GO:0046661
GeneOntologyBiologicalProcessdevelopment of primary sexual characteristics

PATZ1 WNT5A RXFP2 GATA4 AHR TLR9 CSMD1

6.01e-05297697GO:0045137
GeneOntologyBiologicalProcesscolumnar/cuboidal epithelial cell development

WNT5A GATA2 TLR9 CLOCK

8.42e-0569694GO:0002066
GeneOntologyBiologicalProcesssexual reproduction

GMCL1 GMCL2 MSH6 PATZ1 WNT5A CSNK2A2 KAT8 TTC12 RXFP2 GATA4 PAQR5 DCST2 CLOCK CDC23

9.43e-0513126914GO:0019953
GeneOntologyBiologicalProcessmulticellular organismal reproductive process

GMCL1 GMCL2 MSH6 PATZ1 CSNK2A2 KAT8 TTC12 RXFP2 GATA4 PAQR5 DCST2 CSMD1 CLOCK

1.43e-0411946913GO:0048609
GeneOntologyBiologicalProcesssex differentiation

PATZ1 WNT5A RXFP2 GATA4 AHR TLR9 CSMD1

1.73e-04352697GO:0007548
GeneOntologyBiologicalProcessT cell chemotaxis

CCR2 CXCR3 WNT5A

1.82e-0433693GO:0010818
GeneOntologyBiologicalProcessdetection of external biotic stimulus

SCARB1 TLR4 TLR9

1.82e-0433693GO:0098581
GeneOntologyBiologicalProcesspost-embryonic hemopoiesis

KAT8 AHR

2.29e-047692GO:0035166
GeneOntologyBiologicalProcessdetection of lipopolysaccharide

SCARB1 TLR4

2.29e-047692GO:0032497
GeneOntologyBiologicalProcesswound healing

CCR2 WNT5A SCARB1 TLR4 GATA2 GATA4 EXT1 VAV2

2.34e-04493698GO:0042060
GeneOntologyBiologicalProcessglandular epithelial cell differentiation

WNT5A GATA2 EXT1 CLOCK

2.46e-0491694GO:0002067
GeneOntologyBiologicalProcessreproductive structure development

PATZ1 WNT5A RXFP2 GATA4 AHR TLR9 CSMD1

2.89e-04383697GO:0048608
GeneOntologyBiologicalProcessreproductive system development

PATZ1 WNT5A RXFP2 GATA4 AHR TLR9 CSMD1

3.13e-04388697GO:0061458
GeneOntologyBiologicalProcessdetection of chemical stimulus

OR5T3 SCARB1 TLR4 OR52N4 OR1E3 OR10J4 TLR9 OR9G9

3.53e-04524698GO:0009593
GeneOntologyBiologicalProcessgamete generation

GMCL1 GMCL2 MSH6 PATZ1 CSNK2A2 KAT8 TTC12 RXFP2 GATA4 PAQR5 CLOCK

3.90e-049826911GO:0007276
GeneOntologyBiologicalProcesspositive regulation of type II interferon production

CCR2 WNT5A TLR4 TLR9

3.95e-04103694GO:0032729
GeneOntologyBiologicalProcessglandular epithelial cell development

WNT5A GATA2 CLOCK

4.02e-0443693GO:0002068
GeneOntologyBiologicalProcesspositive regulation of inflammatory response

CCR2 WNT5A TLR4 TLR9 CLOCK

4.71e-04193695GO:0050729
GeneOntologyBiologicalProcessdetection of biotic stimulus

SCARB1 TLR4 TLR9

4.91e-0446693GO:0009595
DomainAlg10

ALG10 ALG10B

1.27e-052672IPR016900
DomainRelaxin_rcpt

RXFP2 RXFP1

1.27e-052672IPR008112
DomainDIE2_ALG10

ALG10 ALG10B

1.27e-052672PF04922
DomainMAM

MALRD1 MAMDC2 NPNT

2.89e-0517673SM00137
DomainMAM

MALRD1 MAMDC2 NPNT

3.46e-0518673PF00629
DomainMAM_dom

MALRD1 MAMDC2 NPNT

3.46e-0518673IPR000998
DomainMAM_2

MALRD1 MAMDC2 NPNT

3.46e-0518673PS50060
DomainBTB

GMCL1 GMCL2 PATZ1 KLHL15 KCNS3 ZBTB18

4.52e-05180676SM00225
DomainBTB/POZ_dom

GMCL1 GMCL2 PATZ1 KLHL15 KCNS3 ZBTB18

5.26e-05185676IPR000210
DomainTIR

IL1RAPL2 TLR4 TLR9

5.60e-0521673SM00255
DomainTIR

IL1RAPL2 TLR4 TLR9

6.47e-0522673PF01582
Domain-

IL1RAPL2 TLR4 TLR9

7.42e-05236733.40.50.10140
DomainTIR

IL1RAPL2 TLR4 TLR9

8.46e-0524673PS50104
DomainTIR_dom

IL1RAPL2 TLR4 TLR9

9.59e-0525673IPR000157
DomainBTB

GMCL1 GMCL2 PATZ1 KLHL15 ZBTB18

1.07e-04131675PF00651
DomainBTB

GMCL1 GMCL2 PATZ1 KLHL15 ZBTB18

2.73e-04160675PS50097
DomainLDLR_class-A_CS

MALRD1 RXFP2 RXFP1

3.96e-0440673IPR023415
DomainLdl_recept_a

MALRD1 RXFP2 RXFP1

5.62e-0445673PF00057
DomainSKP1/BTB/POZ

GMCL1 PATZ1 KLHL15 KCNS3 ZBTB18

5.85e-04189675IPR011333
Domain-

MALRD1 RXFP2 RXFP1

6.00e-04466734.10.400.10
DomainLDLRA_1

MALRD1 RXFP2 RXFP1

6.80e-0448673PS01209
DomainAdipoR/HlyIII-related

PAQR5 PAQR6

6.83e-0411672IPR004254
DomainHlyIII

PAQR5 PAQR6

6.83e-0411672PF03006
DomainLDLRA_2

MALRD1 RXFP2 RXFP1

7.22e-0449673PS50068
DomainLDrepeatLR_classA_rpt

MALRD1 RXFP2 RXFP1

7.22e-0449673IPR002172
DomainLDLa

MALRD1 RXFP2 RXFP1

7.22e-0449673SM00192
DomainZnF_GATA

GATA2 GATA4

8.18e-0412672SM00401
DomainZnf_GATA

GATA2 GATA4

1.29e-0315672IPR000679
DomainGATA

GATA2 GATA4

1.29e-0315672PF00320
DomainChemokine_rcpt

CCR2 CXCR3

1.47e-0316672IPR000355
DomainGATA_ZN_FINGER_1

GATA2 GATA4

1.47e-0316672PS00344
DomainMAM_1

MAMDC2 NPNT

1.47e-0316672PS00740
DomainGATA_ZN_FINGER_2

GATA2 GATA4

1.47e-0316672PS50114
DomainPAS_fold_3

AHR CLOCK

3.06e-0323672IPR013655
DomainPAS_3

AHR CLOCK

3.06e-0323672PF08447
DomainLRR_8

TLR4 RXFP2 RXFP1 TLR9

3.32e-03171674PF13855
DomainPAS

AHR CLOCK

3.61e-0325672PF00989
DomainPAS_fold

AHR CLOCK

3.61e-0325672IPR013767
DomainLeu-rich_rpt_typical-subtyp

TLR4 RXFP2 RXFP1 TLR9

3.76e-03177674IPR003591
DomainLRR_TYP

TLR4 RXFP2 RXFP1 TLR9

3.76e-03177674SM00369
DomainPAC

AHR CLOCK

3.90e-0326672IPR001610
DomainPAC

AHR CLOCK

3.90e-0326672SM00086
DomainPAC

AHR CLOCK

3.90e-0326672PS50113
DomainPAS

AHR CLOCK

5.87e-0332672SM00091
DomainLRR

TLR4 RXFP2 RXFP1 TLR9

5.88e-03201674PS51450
Domain-

CLTCL1 TTC12 TRAPPC8 CDC23

6.52e-032076741.25.40.10
DomainPAS

AHR CLOCK

6.60e-0334672IPR000014
DomainPAS

AHR CLOCK

6.60e-0334672PS50112
Pubmed

Hepatic recruitment of macrophages promotes nonalcoholic steatohepatitis through CCR2.

CCR2 TLR4 TLR9

3.12e-08470322442158
Pubmed

Sensing of commensal organisms by the intracellular sensor NOD1 mediates experimental pancreatitis.

CCR2 TLR4 TLR9

1.55e-07670322902233
Pubmed

The Intestinal Microbiome Restricts Alphavirus Infection and Dissemination through a Bile Acid-Type I IFN Signaling Axis.

CCR2 TLR4 TLR9

9.28e-071070332668198
Pubmed

The infarcted myocardium solicits GM-CSF for the detrimental oversupply of inflammatory leukocytes.

CCR2 TLR4 TLR9

1.27e-061170328978634
Pubmed

Commensal-driven immune zonation of the liver promotes host defence.

CCR2 CXCR3 TLR4

2.20e-061370333239787
Pubmed

IL-22 and IDO1 affect immunity and tolerance to murine and human vaginal candidiasis.

TLR4 AHR TLR9

2.80e-061470323853597
Pubmed

The toll-like receptor pathway: a novel mechanism of infection-induced carcinogenesis of prostate epithelial cells.

TLR4 TLR9

3.99e-06270218092352
Pubmed

TLR-Stimulated Eosinophils Mediate Recruitment and Activation of NK Cells In Vivo.

TLR4 TLR9

3.99e-06270228426135
Pubmed

Acquisition of adult-like TLR4 and TLR9 responses during the first year of life.

TLR4 TLR9

3.99e-06270220442853
Pubmed

Assessment of TLR4 and TLR9 signaling and correlation with human papillomavirus status and histopathologic parameters in oral tongue squamous cell carcinoma.

TLR4 TLR9

3.99e-06270232173390
Pubmed

Estrogen decreases expression of chemokine receptors, and suppresses chemokine bioactivity in murine monocytes.

CCR2 CXCR3

3.99e-06270214725563
Pubmed

Mouse germ cell-less as an essential component for nuclear integrity.

GMCL1 GMCL2

3.99e-06270212556490
Pubmed

Increased expression of Toll-like receptors 4 and 9 in human lung cancer.

TLR4 TLR9

3.99e-06270218763053
Pubmed

CCR2 and CXCR3 agonistic chemokines are differently expressed and regulated in human alveolar epithelial cells type II.

CCR2 CXCR3

3.99e-06270216033640
Pubmed

Alveolar bone loss in relation to toll-like receptor 4 and 9 genotypes and Porphyromonas gingivalis carriage.

TLR4 TLR9

3.99e-06270227492306
Pubmed

Relaxin increases human endothelial progenitor cell NO and migration and vasculogenesis in mice.

RXFP2 RXFP1

3.99e-06270222028476
Pubmed

Helicobacter pylori regulates TLR4 and TLR9 during gastric carcinogenesis.

TLR4 TLR9

3.99e-06270225400780
Pubmed

Toll-like receptor gene polymorphisms are associated with susceptibility to Graves' ophthalmopathy in Taiwan males.

TLR4 TLR9

3.99e-06270221050493
Pubmed

TLR4 896A/G and TLR9 1174G/A polymorphisms are associated with the risk of infectious mononucleosis.

TLR4 TLR9

3.99e-06270232753695
Pubmed

Polymorphisms and haplotypes of TLR-4/9 associated with bacterial infection, gingival inflammation/recession and oral cancer.

TLR4 TLR9

3.99e-06270236563560
Pubmed

TLR4 and TLR9 polymorphism: Probable role in susceptibility among the population of Bihar for Indian visceral leishmaniasis.

TLR4 TLR9

3.99e-06270233910419
Pubmed

The different ligand-binding modes of relaxin family peptide receptors RXFP1 and RXFP2.

RXFP2 RXFP1

3.99e-06270222973049
Pubmed

Polymorphisms and expression of TLR4 and 9 in malaria in two ethnic groups of Assam, northeast India.

TLR4 TLR9

3.99e-06270222948021
Pubmed

Influence of TLR4 and TLR9 polymorphisms and haplotypes on multiple hrHPV infections and HPV16 copy number in cervical cancer and cervicitis.

TLR4 TLR9

3.99e-06270234416273
Pubmed

Common polymorphisms of toll-like receptors 4 and 9 are associated with the clinical manifestation of malaria during pregnancy.

TLR4 TLR9

3.99e-06270216779724
Pubmed

TLR9 2848 GA heterozygotic status possibly predisposes fetuses and newborns to congenital infection with human cytomegalovirus.

TLR4 TLR9

3.99e-06270225844529
Pubmed

Molecular cloning and genomic organization of mouse homologue of Drosophila germ cell-less and its expression in germ lineage cells.

GMCL1 GMCL2

3.99e-06270210448096
Pubmed

Signaling crosstalk during sequential TLR4 and TLR9 activation amplifies the inflammatory response of mouse macrophages.

TLR4 TLR9

3.99e-06270219923461
Pubmed

Differential involvement of IFN-beta in Toll-like receptor-stimulated dendritic cell activation.

TLR4 TLR9

3.99e-06270212356687
Pubmed

Immunohistochemical expression of TLR4 and TLR9 in various grades of oral epithelial dysplasia and squamous cell carcinoma, and their roles in tumor progression: a pilot study.

TLR4 TLR9

3.99e-06270223651260
Pubmed

Gene Polymorphisms of TLR4 and TLR9 and Haemophilus influenzae Meningitis in Angolan Children.

TLR4 TLR9

3.99e-06270232967147
Pubmed

Resolving the unconventional mechanisms underlying RXFP1 and RXFP2 receptor function.

RXFP2 RXFP1

3.99e-06270219416161
Pubmed

Modeling the primary hormone-binding site of RXFP1 and RXFP2.

RXFP2 RXFP1

3.99e-06270219416162
Pubmed

Diverse Profiles of Toll-Like Receptors 2, 4, 7, and 9 mRNA in Peripheral Blood and Biopsy Specimens of Patients with Celiac Disease.

TLR4 TLR9

3.99e-06270230057921
Pubmed

The Impact of Circulating Mitochondrial DNA on Cardiomyocyte Apoptosis and Myocardial Injury After TLR4 Activation in Experimental Autoimmune Myocarditis.

TLR4 TLR9

3.99e-06270228618428
Pubmed

TLR4- and TLR9-dependent effects on cytokines, cell viability, and invasion in human bladder cancer cells.

TLR4 TLR9

3.99e-06270225499923
Pubmed

Interactions of surface-expressed TLR-4 and endosomal TLR-9 accelerate lupus progression in anti-dsDNA antibody transgenic mice.

TLR4 TLR9

3.99e-06270224719374
Pubmed

Differential cell reaction upon Toll-like receptor 4 and 9 activation in human alveolar and lung interstitial macrophages.

TLR4 TLR9

3.99e-06270220843333
Pubmed

Associations of toll-like receptor 4 and 2 gene polymorphisms with susceptibility to ankylosing spondylitis: A meta-analysis.

TLR4 TLR9

3.99e-06270233369094
Pubmed

TLR9 and MyD88 are crucial for the development of protective immunity to malaria.

TLR4 TLR9

3.99e-06270222516959
Pubmed

Flexibility of mouse classical and plasmacytoid-derived dendritic cells in directing T helper type 1 and 2 cell development: dependency on antigen dose and differential toll-like receptor ligation.

TLR4 TLR9

3.99e-06270212515817
Pubmed

Association of TLR4 and TLR9 gene polymorphisms and haplotypes with cervicitis susceptibility.

TLR4 TLR9

3.99e-06270231365550
Pubmed

Cigarette smoke increases TLR4 and TLR9 expression and induces cytokine production from CD8(+) T cells in chronic obstructive pulmonary disease.

TLR4 TLR9

3.99e-06270222070100
Pubmed

Study of disease-relevant polymorphisms in the TLR4 and TLR9 genes: a novel method applied to the analysis of the Portuguese population.

TLR4 TLR9

3.99e-06270217482427
Pubmed

Genetic variants of TLR4 and TLR9 are risk factors for chronic Helicobacter pylori infection in South Indian Tamils.

TLR4 TLR9

3.99e-06270227993530
Pubmed

Splice variants of the relaxin and INSL3 receptors reveal unanticipated molecular complexity.

RXFP2 RXFP1

3.99e-06270216051677
Pubmed

Association of polymorphisms in Toll-like receptors 4 and 9 with risk of pulmonary tuberculosis: a meta-analysis.

TLR4 TLR9

3.99e-06270225889916
Pubmed

Toll-like receptor 9 deficiency impacts sensory and motor behaviors.

TLR4 TLR9

3.99e-06270223624295
Pubmed

[Association of Toll-like receptor gene with Crohn's disease in Koreans].

TLR4 TLR9

3.99e-06270220026892
Pubmed

Association of TLR4 and TLR9 polymorphisms and haplotypes with cervical cancer susceptibility.

TLR4 TLR9

3.99e-06270231278284
Pubmed

Critical role of TLR9 in acute graft-versus-host disease.

TLR4 TLR9

3.99e-06270218941203
Pubmed

Enhancing mucosal immunity by transient microbiota depletion.

CCR2 CXCR3

3.99e-06270232901029
Pubmed

Toll-like receptor gene variants associated with bacterial vaginosis among HIV-1 infected adolescents.

TLR4 TLR9

3.99e-06270223021866
Pubmed

The agonists of TLR4 and 9 are sufficient to activate memory B cells to differentiate into plasma cells in vitro but not in vivo.

TLR4 TLR9

3.99e-06270218641311
Pubmed

Association of TLR4 and TLR9 gene polymorphisms with cervical HR-HPV infection status in Chinese Han population.

TLR4 TLR9

3.99e-06270236915050
Pubmed

Polymorphisms in Toll-like receptors genes changes the host's immune response and is associated with cervical cancer.

TLR4 TLR9

3.99e-06270235158151
Pubmed

TLR9 and TLR4 are required for the development of autoimmunity and lupus nephritis in pristane nephropathy.

TLR4 TLR9

3.99e-06270220810248
Pubmed

Stage-specific expression of mouse germ cell-less-1 (mGCL-1), and multiple deformations during mgcl-1 deficient spermatogenesis leading to reduced fertility.

GMCL1 GMCL2

3.99e-06270215700541
Pubmed

TLR4 deficiency upregulates TLR9 expression and enhances irinotecan-related intestinal mucositis and late-onset diarrhoea.

TLR4 TLR9

3.99e-06270234216140
Pubmed

Association between TLR4 and TLR9 gene polymorphisms with development of pulmonary tuberculosis in Zahedan, southeastern Iran.

TLR4 TLR9

3.99e-06270223766695
Pubmed

TLR4 and TLR9 are induced in oral lichen planus.

TLR4 TLR9

3.99e-06270222672741
Pubmed

Association of TLR4 and TLR9 gene polymorphisms with the risk and progression of cervical lesions in HPV-infected women.

TLR4 TLR9

3.99e-06270237097031
Pubmed

TLR4 and TLR9 polymorphisms are not associated with either rheumatoid arthritis or systemic lupus erythematosus in Mexican patients.

TLR4 TLR9

3.99e-06270233939072
Pubmed

Characterization of novel splice variants of LGR7 and LGR8 reveals that receptor signaling is mediated by their unique low density lipoprotein class A modules.

RXFP2 RXFP1

3.99e-06270216963451
Pubmed

Using real time RT-PCR analysis to determine multiple gene expression patterns during XX and XY mouse fetal gonad development.

WNT5A SCARB1 GATA2 GATA4

4.41e-065470415533830
Pubmed

Conditional mutagenesis of the murine serum response factor gene blocks cardiogenesis and the transcription of downstream gene targets.

WNT5A GATA2 GATA4

6.23e-061870315929941
Pubmed

Experimental priming of encephalitogenic Th1/Th17 cells requires pertussis toxin-driven IL-1β production by myeloid cells.

CCR2 TLR4 TLR9

1.01e-052170327189410
Pubmed

A novel role for relaxin-2 in the pathogenesis of primary varicosis.

RXFP2 RXFP1

1.20e-05370222737225
Pubmed

TLR2, TLR4 and TLR9 polymorphisms and Crohn's disease in a New Zealand Caucasian cohort.

TLR4 TLR9

1.20e-05370217914947
Pubmed

Tumor Exosomal RNAs Promote Lung Pre-metastatic Niche Formation by Activating Alveolar Epithelial TLR3 to Recruit Neutrophils.

TLR4 TLR9

1.20e-05370227505671
Pubmed

Expression of toll-like receptors on antigen-presenting cells in patients with falciparum malaria.

TLR4 TLR9

1.20e-05370217854755
Pubmed

A point mutation in the gene for asparagine-linked glycosylation 10B (Alg10b) causes nonsyndromic hearing impairment in mice (Mus musculus).

ALG10 ALG10B

1.20e-05370224303013
Pubmed

Recombinant Wnt3a and Wnt5a elicit macrophage cytokine production and tolerization to microbial stimulation via Toll-like receptor 4.

WNT5A TLR4

1.20e-05370224643512
Pubmed

Enhanced efficacy of therapeutic cancer vaccines produced by co-treatment with Mycobacterium tuberculosis heparin-binding hemagglutinin, a novel TLR4 agonist.

TLR4 TLR9

1.20e-05370221368092
Pubmed

Rare genetic variants in GATA transcription factors in patients with hypertrophic cardiomyopathy.

GATA2 GATA4

1.20e-05370228381408
Pubmed

[Toll-like receptor gene polymorphisms and susceptibility to inflammatory bowel disease in Chinese Han and Caucasian populations].

TLR4 TLR9

1.20e-05370220646633
Pubmed

Toll-like receptor (TLR) polymorphisms in African children: Common TLR-4 variants predispose to severe malaria.

TLR4 TLR9

1.20e-05370216371473
Pubmed

Toll-like receptor signaling in anti-cancer immunity.

TLR4 TLR9

1.20e-05370212630564
Pubmed

Single-nucleotide polymorphisms in the Toll-like receptor pathway increase susceptibility to infections in severely injured trauma patients.

TLR4 TLR9

1.20e-05370223425749
Pubmed

Systemically administered ligands of Toll-like receptor 2, -4, and -9 induce distinct inflammatory responses in the murine lung.

TLR4 TLR9

1.20e-05370221547259
Pubmed

CXCL10 impairs beta cell function and viability in diabetes through TLR4 signaling.

CXCR3 TLR4

1.20e-05370219187771
Pubmed

A pilot study on expression of toll like receptors (TLRs) in response to herpes simplex virus (HSV) infection in acute retinal pigment epithelial cells (ARPE) cells.

TLR4 TLR9

1.20e-05370225121361
Pubmed

Conventional DCs reduce liver ischemia/reperfusion injury in mice via IL-10 secretion.

CCR2 TLR9

1.20e-05370220093775
Pubmed

Toll-like receptor stimulation enhances phagocytosis and intracellular killing of nonencapsulated and encapsulated Streptococcus pneumoniae by murine microglia.

TLR4 TLR9

1.20e-05370219933834
Pubmed

Activation of enteroendocrine cells via TLRs induces hormone, chemokine, and defensin secretion.

TLR4 TLR9

1.20e-05370217371986
Pubmed

Toll-like receptor 4 (TLR4), but not TLR3 or TLR9, knock-out mice have neuroprotective effects against focal cerebral ischemia.

TLR4 TLR9

1.20e-05370220804821
Pubmed

Polymorphisms in toll-like receptor genes and susceptibility to pulmonary aspergillosis.

TLR4 TLR9

1.20e-05370218275280
Pubmed

TLR4-mediated skin carcinogenesis is dependent on immune and radioresistant cells.

TLR4 TLR9

1.20e-05370220526283
Pubmed

Functional Toll-Like Receptor 9 Expression and CXCR3 Ligand Release in Pulmonary Sarcoidosis.

CXCR3 TLR9

1.20e-05370227390897
Pubmed

Polymorphisms in Toll-like receptor genes and susceptibility to infections in allogeneic stem cell transplantation.

TLR4 TLR9

1.20e-05370219539691
Pubmed

Toll-like receptor 2 regulates CXC chemokine production and neutrophil recruitment to the cornea in Onchocerca volvulus/Wolbachia-induced keratitis.

TLR4 TLR9

1.20e-05370217875630
Pubmed

Polymorphisms in Toll-like receptors 2, 4, and 9 are highly associated with hearing loss in survivors of bacterial meningitis.

TLR4 TLR9

1.20e-05370222662111
Pubmed

Impaired Surface Expression of HLA-DR, TLR2, TLR4, and TLR9 in Ex Vivo-In Vitro Stimulated Monocytes from Severely Injured Trauma Patients.

TLR4 TLR9

1.20e-05370228255201
Pubmed

Cathelicidin modulates synthesis of Toll-like Receptors (TLRs) 4 and 9 in colonic epithelium.

TLR4 TLR9

1.20e-05370228988039
Pubmed

Association between genetic variants of TLR2, TLR4, TLR9 and schizophrenia.

TLR4 TLR9

1.20e-05370237718198
Pubmed

Essential genes Ptgs2, Tlr4, and Ccr2 regulate neuro-inflammation during the acute phase of cerebral ischemic in mice.

CCR2 TLR4

1.20e-05370237563282
Pubmed

Identification of key residues essential for the structural fold and receptor selectivity within the A-chain of human gene-2 (H2) relaxin.

RXFP2 RXFP1

1.20e-05370223024363
Pubmed

Evaluation of the detection of Toll-like receptors (TLRs) in cancer development and progression in patients with colorectal cancer.

TLR4 TLR9

1.20e-05370229883450
Pubmed

Stimulation of allergen-loaded macrophages by TLR9-ligand potentiates IL-10-mediated suppression of allergic airway inflammation in mice.

TLR4 TLR9

1.20e-05370215538945
Pubmed

TLR9 cooperates with TLR4 to increase IL-12 release by murine dendritic cells.

TLR4 TLR9

1.20e-05370217599410
GeneFamilyAlpha-1,2-glucosyltransferases

ALG10 ALG10B

8.43e-062532448
GeneFamilyRelaxin family peptide receptors

RXFP2 RXFP1

5.04e-054532217
GeneFamilyCD molecules|Toll like receptors

TLR4 TLR9

3.74e-0410532948
GeneFamilyProgestin and adipoQ receptor family

PAQR5 PAQR6

4.56e-0411532930
GeneFamilyBasic leucine zipper proteins|BTB domain containing

GMCL1 PATZ1 KLHL15 ZBTB18

6.38e-04134534861
GeneFamilyGATA zinc finger domain containing|Myb/SANT domain containing

GATA2 GATA4

8.64e-041553282
GeneFamilyZinc fingers ZZ-type|Lysine acetyltransferases

KAT8 CLOCK

1.11e-0317532486
ToppCell5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell-EC_arterial-EC_arterial_L.2.4.1.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PLCD3 TMC7 ST6GALNAC3 DOCK9 GATA2 RXFP1

3.70e-07183686ce8be9418b473ea94ec806edc7a2078cc30c1703
ToppCellLA-16._Neuronal|LA / Chamber and Cluster_Paper

IL1RAPL2 ST6GALNAC3 AHR MBOAT2 SDHD

5.89e-06168685c55bbfbde8bb954f1cb9af82007bdd1f8070fee3
ToppCellPND07-28-samps-Endothelial-Postnatal_endothelial-capillary_endothelial_Hpgd-CA4_high|PND07-28-samps / Age Group, Lineage, Cell class and subclass

DOCK9 SCARB1 GATA2 AHR ZBTB18

8.46e-061816859cd5e5c285c2b628db9d59709af053defd7c0aff
ToppCellControl-Endothelial_cells-Endothelial_cells_(general)|Control / group, cell type (main and fine annotations)

ST6GALNAC3 DOCK9 GATA2 RXFP1 MBOAT2

9.91e-06187685fb5bcbc8effdbf0e57fcb71aca990a4aa0d65ce8
ToppCellnucseq-Endothelial-Endothelial_Vascular-Endothelial_capillary|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ST6GALNAC3 DOCK9 GATA2 RXFP1 MBOAT2

1.15e-05193685f582e939e3e08a8a3f71deec78c33715be8faa51
ToppCellnucseq-Endothelial-Endothelial_Vascular-Endothelial_capillary-CAP1|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ST6GALNAC3 DOCK9 GATA2 RXFP1 MBOAT2

1.15e-05193685ad3f4fcc8e2816d696cbcde744dc16500e51ccac
ToppCellChildren_(3_yrs)-Endothelial-capillary_endothelial_cell_(Cap1)|Children_(3_yrs) / Lineage, Cell type, age group and donor

ST6GALNAC3 DOCK9 GATA2 RXFP1 MBOAT2

1.18e-0519468571ac69cdf7a08ca3ddfb5b492b14ac56b6cd5e5d
ToppCellChildren_(3_yrs)-Endothelial-capillary_endothelial_cell_(Cap1)-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

ST6GALNAC3 DOCK9 GATA2 RXFP1 MBOAT2

1.18e-0519468568004855b23fe1e31e8452d70effabc78a4a0bd3
ToppCellChildren_(3_yrs)-Endothelial-capillary_endothelial_cell_(Cap1)-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

ST6GALNAC3 DOCK9 GATA2 RXFP1 MBOAT2

1.18e-0519468540842a7160f337bfc191ee15fbda3e3d38a04c57
ToppCellnucseq-Endothelial-Endothelial_Vascular|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ST6GALNAC3 DOCK9 GATA2 RXFP1 MBOAT2

1.24e-05196685686533fd3fba8e4df96b9dd1307e870e89db4332
ToppCellFetal_29-31_weeks-Endothelial|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ST6GALNAC3 DOCK9 SCARB1 GATA2 RXFP1

1.24e-051966853981f6c7487598f4f7ce4650ac0ac5bd41481d66
ToppCellBronchial-NucSeq-Endothelial-Endothelia_vascular-VE_capillary|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ST6GALNAC3 SCARB1 GATA2 RXFP1 MBOAT2

1.27e-0519768581718164c9802ee20c860ffbda7e62d5e9a76f16
ToppCellCOVID-19-lung-Capillary_2|COVID-19 / Disease (COVID-19 only), tissue and cell type

ST6GALNAC3 DOCK9 GATA2 RXFP1 CSMD1

1.31e-0519868545419f2804b4be79bae6632e71c54e1af482d115
ToppCellCOVID-19-lung-Capillary_2|lung / Disease (COVID-19 only), tissue and cell type

ST6GALNAC3 DOCK9 GATA2 RXFP1 CSMD1

1.34e-05199685793ce71b78a68033ef4419ed571e1dd86b40124f
ToppCellTracheal-10x3prime_v2-Endothelial-Endothelia_vascular-VE_pulmonary_arterial|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

ST6GALNAC3 GATA2 PAQR5 RXFP1 PPFIA3

1.34e-05199685fff88d2bba262583bb726900ae01e44954b72eb9
ToppCellControl_saline-Hematopoietic_Myeloid-Granulocytic_cells-Mast-cells|Control_saline / Treatment groups by lineage, cell group, cell type

LEKR1 GATA2 GATA4 PAQR5 PAQR6

1.37e-0520068558b25dc2d29e98354bfc8e8e161796c237c3dc23
ToppCell343B-Epithelial_cells-Epithelial-E_(AT2)-|343B / Donor, Lineage, Cell class and subclass (all cells)

MALRD1 TRAM1L1 WNT5A PAQR6

7.18e-0514568480684ec249fa445c1b35f94608a4a6824d53f2d9
ToppCell343B-Epithelial_cells-Epithelial-E_(AT2)|343B / Donor, Lineage, Cell class and subclass (all cells)

MALRD1 TRAM1L1 WNT5A PAQR6

7.18e-05145684cb534333fba44b241b14fb0d7b74e843f4e7f9f8
ToppCell368C-Endothelial_cells-Endothelial-E|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

CLTCL1 POLE SCARB1 RXFP1

9.53e-051566844877aabf647238c0279e497345b6a6d5ee07ef9c
ToppCell368C-Endothelial_cells-Endothelial-E-|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

CLTCL1 POLE SCARB1 RXFP1

9.53e-051566841d681fa17e62815f5d5f90c86be3c248b38e011b
ToppCellControl-MAIT|World / Disease group and Cell class

CSNK2A2 KAT8 LEKR1 VAV2

1.13e-041636840ca4b835936b4f82217cbe57210c1dd90986c1d0
ToppCellMultiple_Sclerosis-Other-HSPC|Multiple_Sclerosis / Disease, Lineage and Cell Type

MALRD1 MAMDC2 GATA2 RXFP1

1.16e-041646846af5529507d695b347adee4be5ead70f56c9cf55
ToppCellfacs-Lung-nan-3m-Myeloid-myeloid_dendritic_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CCR2 TLR4 PAQR5 TLR9

1.21e-041666845c132f505dc5f699c87913f140344fc9f8e7e0f5
ToppCellE18.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP2-CAP2_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SCARB1 GATA2 AHR SERINC3

1.30e-0416968441ad349806b279fbe1374b7e3cc7f146a11adb44
ToppCellE18.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP2|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SCARB1 GATA2 AHR SERINC3

1.30e-0416968442782c61592742190ab0cba8a94f8bdf9c278f90
ToppCell368C-Myeloid-Macrophage-SPP1+_Macrophage_2|Macrophage / Donor, Lineage, Cell class and subclass (all cells)

POLE SCARB1 KLHL15 KCNS3

1.30e-04169684ea600c63cf9572bc4b3cad6392f67bd0d92c7fc9
ToppCellNS-critical-d_0-4-Myeloid-Monocyte-derived_Macrophage|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

PATZ1 WNT5A DOCK9 EXT1

1.33e-04170684adf73bdc049d508f8873c22539db2ca92052a97b
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_artery-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

TMC7 ST6GALNAC3 DOCK9 CSMD1

1.36e-041716841597459c971d6befa991d59dc66b41b6a522f797
ToppCellNS-critical-d_0-4-Epithelial-FOXN4+|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

PLCD3 ANKEF1 RTTN DCST2

1.39e-04172684a00bb44d33658cb3a98accd6b60f3ce964c425b4
ToppCellControl-MAIT|Control / Disease group and Cell class

CSNK2A2 LEKR1 TLR4 VAV2

1.39e-04172684552bc62e8e8bb0ac1cd0452f4410a3af087787eb
ToppCellPND14-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-NK-NK_G2M|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CXCR3 ERICH3 DNAJC16 POLE

1.39e-04172684dd9ba79e1542fe9fa2c319077d83dd3fc0158f46
ToppCell368C-Endothelial_cells-Endothelial-B_(Artery)-|368C / Donor, Lineage, Cell class and subclass (all cells)

TMC7 DOCK9 GATA2 PPFIA3

1.42e-04173684ec88e871b49331fca59bc610a8ae58e2d5e76bc1
ToppCell368C-Endothelial_cells-Endothelial-B_(Artery)|368C / Donor, Lineage, Cell class and subclass (all cells)

TMC7 DOCK9 GATA2 PPFIA3

1.42e-0417368422200fe74e33e2beae0eed289ca8476bbc0b1b2d
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5-Exc_L5-6_RORB_LINC00320|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

IL1RAPL2 OR52N4 RXFP1 DNAH14

1.42e-041736844ec147479b359cce1975d57a50ee1437a0e1e663
ToppCellPND01-03-samps-Endothelial-Postnatal_endothelial-capillary_endothelial_Hpgd-CA4_high|PND01-03-samps / Age Group, Lineage, Cell class and subclass

ST6GALNAC3 DOCK9 GATA2 AHR

1.45e-04174684cb0109661e8c9ca04d67d33f2d926f0e649bf67d
ToppCellASK428-Immune-B_cell|ASK428 / Donor, Lineage and Cell class of Lung cells from Dropseq

MSH6 CXCR3 SCARB1 CSMD1

1.45e-04174684b5a7a612a515736cf3489afd0f6ad2054d54526f
ToppCelldroplet-Limb_Muscle-MUSCLE-1m-Endothelial-unknown|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GMCL1 PAQR6 PRORP MBOAT2

1.45e-04174684c58328c2f262506a4518f49f148e29874faf9171
ToppCell5'-Adult-LymphNode-Endothelial-lymphatic_endothelial-LEC5_(CLDN11+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TRAM1L1 ST6GALNAC3 DOCK9 GATA2

1.58e-041786844b3ea0921bc598ebb9f63780ecdf8ad4349f3666
ToppCell368C-Endothelial_cells-Endothelial-E|368C / Donor, Lineage, Cell class and subclass (all cells)

DOCK9 SCARB1 GATA2 RXFP1

1.65e-041806848ab16a0b9053bffc07b569a4f9e71749f56dde7e
ToppCell368C-Endothelial_cells-Endothelial-E-|368C / Donor, Lineage, Cell class and subclass (all cells)

DOCK9 SCARB1 GATA2 RXFP1

1.65e-04180684394cd465b88429b70eebb2957480dffcbc51cfe7
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Endothelial|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

WNT5A GATA2 AHR PAQR5

1.72e-04182684e6a734fb29105093d4cbfc3d0619a825b66da034
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Endothelial-Endothelial_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

WNT5A GATA2 AHR PAQR5

1.72e-04182684ccc313ecc0bfd8e2c6bb83a565b427b2310485ec
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Endothelial-endothelial_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

WNT5A GATA2 AHR PAQR5

1.72e-04182684b9f758961fb4a586ae86fa0b25edb8ce4616d644
ToppCelldroplet-Lung-nan-21m-Mesenchymal-Myofibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

WNT5A GATA4 KCNS3 CSMD1

1.76e-04183684b153425ab0df1e5fa9b953e1f6d4e8e3dc6621b0
ToppCelldroplet-Lung-nan-21m-Mesenchymal-pulmonary_interstitial_fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

WNT5A GATA4 KCNS3 CSMD1

1.76e-0418368419e7be1cfdd111bfb840532a6f7c780345dffccf
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

IL1RAPL2 TRPV6 RXFP1 MBOAT2

1.80e-04184684ca35a3d2b536c8b2bf5c4d635605e5a3ae94a428
ToppCellfacs-Limb_Muscle-Muscle_forelimb_and_hindlimb-18m-Endothelial-endothelial_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ST6GALNAC3 DOCK9 SCARB1 GATA2

1.83e-04185684c3105978d971da7d0fad1a717ee29afee5ed6357
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)|Adult / Lineage, Cell type, age group and donor

MALRD1 ST6GALNAC3 WNT5A NPNT

1.83e-04185684673f0c688ae6984bc8027df2da335787924f4137
ToppCellfacs-Limb_Muscle-Muscle_forelimb_and_hindlimb-18m-Endothelial-nan|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ST6GALNAC3 DOCK9 SCARB1 GATA2

1.83e-041856844cfef50aeed5b3000ce5e864a41c13740b8267b1
ToppCellpdx-Tumor_cells-T0|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

SCARB1 ANKEF1 GATA4 VAV2

1.83e-041856841d874608aa2062024323512f68889219471b2f00
ToppCellCV-Healthy-7|Healthy / Virus stimulation, Condition and Cluster

URB1 DOCK9 ALG10 ALG10B

1.83e-041856841979d189c204f4c2893e3170a514ee7d5523406c
ToppCellAdult-Endothelial-capillary_endothelial_cell_(Cap1)-D231|Adult / Lineage, Cell type, age group and donor

ST6GALNAC3 GATA2 RXFP1 MBOAT2

1.83e-0418568407f9f38f0739d7c830641723a38385550ac1ac92
ToppCellfacs-Limb_Muscle-Muscle_forelimb_and_hindlimb-18m-Endothelial|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ST6GALNAC3 DOCK9 SCARB1 GATA2

1.83e-0418568409256c6f42f59b7eb89160b2ea706172a5b743be
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_artery-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

ST6GALNAC3 DOCK9 RXFP1 CSMD1

1.83e-04185684a7ae76058b2082020cadec49d63b9f4e24d21734
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6-Exc_L6_THEMIS_EGR3|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

IL1RAPL2 TRPV6 RXFP1 MBOAT2

1.87e-0418668477b09af860183606a1775eba921e2071e4a7dd4e
ToppCellControl-Endothelial_cells-Endothelial_cells_(other)|Control / group, cell type (main and fine annotations)

ST6GALNAC3 DOCK9 GATA2 RXFP1

1.87e-04186684c6075fe84226b370c5139066793844ad33ae2db1
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Endothelial-endothelial_cell|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ST6GALNAC3 DOCK9 SCARB1 AHR

1.91e-041876843548a9914c2b2f5d805798ce22ab26eab6d03897
ToppCellLV-10._Endothelium_II|World / Chamber and Cluster_Paper

ST6GALNAC3 DOCK9 GATA2 EXT1

1.91e-041876847876dcb4800c2e54874df3d933efb79307a64a97
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Endothelial-endothelial_cell|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ST6GALNAC3 DOCK9 SCARB1 AHR

1.91e-04187684f4de4b7af1fdfbd628b1f509c060c1079d2e5437
ToppCellPCW_07-8.5-Endothelial-Endothelial_mature-endo_capillary_(2)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

DOCK9 GATA2 AHR RXFP1

1.91e-04187684106f50ad85a92403037214f0e94702230284837f
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Endothelial|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ST6GALNAC3 DOCK9 SCARB1 AHR

1.91e-0418768481754e965848b718be20ee97ce072ce426938a69
ToppCellP03-Endothelial-capillary_endothelial_cell-capillary_endothelial_cell_of_alveolus|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

SCARB1 GATA2 AHR SERINC3

1.91e-0418768455618ceec367c1c51ed5c447063d7fbd5c7e0808
ToppCellControl-Endothelial_cells-Arterial_endothelial_cells|Control / group, cell type (main and fine annotations)

ST6GALNAC3 DOCK9 RXFP1 CSMD1

1.91e-0418768481affaab3fe3e1daea45ada6445e906ddd33950e
ToppCellAdult-Endothelial-capillary_endothelial_cell_(Cap1)-D122|Adult / Lineage, Cell type, age group and donor

ST6GALNAC3 GATA2 RXFP1 MBOAT2

1.95e-0418868402a62888e9db29d20133eeca1686d302545a39c9
ToppCelldroplet-Lung-21m-Mesenchymal-myofibroblast-myofibroblast_cell-pulmonary_interstitial_myofibroblast|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

WNT5A GATA4 KCNS3 CSMD1

1.99e-04189684cd42ce4aa217d0bd95e0cc0ba357bdfeb3e55a48
ToppCelldroplet-Lung-21m-Mesenchymal-myofibroblast-myofibroblast_cell|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

WNT5A GATA4 KCNS3 CSMD1

1.99e-04189684102501eee7760d5882dec41ea9d00147b3f4fb73
ToppCelldroplet-Limb_Muscle-nan-18m-Endothelial|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK9 SCARB1 GATA2 SERINC3

1.99e-04189684a3f6ebd1622d36d114e42f6e0618d7b2fe8b9a2f
ToppCellnucseq-Endothelial-Endothelial_Vascular-Endothelial_capillary-CAP2|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ST6GALNAC3 DOCK9 GATA2 MBOAT2

1.99e-04189684b6b4da51bc7f2c13a2f940540fdc61027d084835
ToppCelldroplet-Limb_Muscle-nan-18m-Endothelial-nan|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK9 SCARB1 GATA2 SERINC3

1.99e-04189684d86455cf20769d70d62e2c1dd92cbc93c67aada5
ToppCellEndothelial-endothelial_cell_of_artery|World / Lineage, Cell type, age group and donor

ST6GALNAC3 DOCK9 GATA2 CSMD1

1.99e-04189684fdd89c71113ac99b7c800c6def8888e512ff1128
ToppCellCOVID-19-Heart-EC_(POSTN)|COVID-19 / Disease (COVID-19 only), tissue and cell type

ST6GALNAC3 DOCK9 GATA4 CSMD1

1.99e-041896847346c1112e2e155dbd71b6dbc80e680fd262a691
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

IL1RAPL2 GATA2 MBOAT2 VAV2

1.99e-04189684fc88c51ace7d883c01617f3f9b5fab70cc91cc09
ToppCelldroplet-Limb_Muscle-nan-18m-Endothelial-endothelial_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK9 SCARB1 GATA2 SERINC3

1.99e-0418968484036d1257f6b18f47cfc7ac5e6ed6ea3553c235
ToppCelldroplet-Lung-21m-Mesenchymal-myofibroblast|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

WNT5A GATA4 KCNS3 CSMD1

1.99e-041896846e83bf855d4771885b60bb8992df2f9b508eef97
ToppCellCOVID-19-Endothelial_cells-Endothelial_cells_(general)|COVID-19 / group, cell type (main and fine annotations)

ST6GALNAC3 DOCK9 GATA2 RXFP1

2.03e-04190684812e11314c76c0179fbe5a9bea29b41ce5cbc93d
ToppCellPND01-Endothelial-Endothelial_blood-vessel|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SCARB1 GATA2 AHR SERINC3

2.03e-041906842803eb02209591a63fe13e834e4e0f8014e1aa34
ToppCellE17.5-Endothelial|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

SCARB1 GATA2 AHR SERINC3

2.03e-041906844fb76195ec9d6e0260a628eef6c2b3705acce787
ToppCellChildren_(3_yrs)-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

ST6GALNAC3 DOCK9 GATA2 MBOAT2

2.03e-041906840a351609a72fd638c84b2435782e312ee6a33aac
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_artery|Children_(3_yrs) / Lineage, Cell type, age group and donor

ST6GALNAC3 DOCK9 RXFP1 CSMD1

2.03e-04190684f6c38d197fd9d69a4f97cb2e72cd4747984c1a86
ToppCell10x5'v1-week_14-16-Myeloid_DC-DC|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

CCR2 CXCR3 RXFP1 TLR9

2.03e-04190684d06800ec9f6065c1cc536ed99e8569732272a94f
ToppCell10x5'v1-week_14-16-Myeloid_DC|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

CCR2 CXCR3 RXFP1 TLR9

2.03e-04190684485073e831afebdb393c7f4b622504d43d1b778b
ToppCellPCW_07-8.5-Endothelial-Endothelial_cycling-endo_proliferating1_(10)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

DOCK9 GATA2 AHR RXFP1

2.07e-04191684edfd5eeff69b5de19c5df3d899e42acd7e015913
ToppCellnucseq-Endothelial-Endothelial_Vascular-Endothelial_large_blood_vessel-AEC|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ST6GALNAC3 DOCK9 RXFP1 CSMD1

2.07e-0419168450601ef0a5a8f2c2120922989e08e85bf2d9b4ab
ToppCellPND01-Endothelial|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SCARB1 GATA2 AHR SERINC3

2.07e-0419168496b9b0aaf0cb2d6f929ff563dbaedc83ffb4795e
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

IL1RAPL2 GATA2 TRPV6 VAV2

2.11e-04192684fd08ae787e936cfdb1ab8f19b0fd63005b462709
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2-D122|Adult / Lineage, Cell type, age group and donor

DOCK9 PAQR5 DNAH14 NPNT

2.11e-0419268406013a07e3a873b1d1c0451643c528593ac32a9c
ToppCellfacs-MAT-Fat-24m-Endothelial-nan|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK9 SCARB1 GATA2 PAQR5

2.16e-04193684ba9a47e2dc01efa6d2a99b1631d4951fac2648d4
ToppCellfacs-MAT-Fat-24m-Endothelial-endothelial_cell|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK9 SCARB1 GATA2 PAQR5

2.16e-04193684724bb613fa434add5b1c5586b629328f819fbdfe
ToppCellAdult-Endothelial-capillary_endothelial_cell_(Cap1)|Adult / Lineage, Cell type, age group and donor

ST6GALNAC3 GATA2 RXFP1 MBOAT2

2.16e-0419368439c6c96a2a100b1b290a779d36cc6bc17245720b
ToppCellfacs-MAT-Fat-3m-Endothelial|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ST6GALNAC3 DOCK9 SCARB1 GATA2

2.16e-04193684b32533afeff1905e188becaa09079e9699722e4b
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Inner_Medullary_Collecting_Duct_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PLCD3 TMC7 IL1RAPL2 AHR

2.16e-04193684a5695ce2e24a62026ae28f3dea07ca4a435206b8
ToppCellfacs-MAT-Fat-3m-Endothelial-nan|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ST6GALNAC3 DOCK9 SCARB1 GATA2

2.16e-041936842ff573ba2c74583ed1cb071a3bbc01bb71117e5f
ToppCellPND01-Endothelial-Endothelial_blood-vessel-Microvascular_EC|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SCARB1 GATA2 AHR SERINC3

2.16e-0419368430254658a2023ea9808cdd786530b966a1446418
ToppCellPCW_07-8.5-Endothelial-Endothelial_immature-endo_immature4_(5)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

DOCK9 GATA2 AHR RXFP1

2.16e-0419368472d20ee257149b238016b44d183ce3fc24b8f621
ToppCellfacs-MAT-Fat-3m-Endothelial-endothelial_cell|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ST6GALNAC3 DOCK9 SCARB1 GATA2

2.16e-04193684e164f6403a8b541ced08a6feec915d2e855036ea
ToppCellFetal_29-31_weeks-Endothelial-capillary_endothelial_cell_(Cap1)-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

DOCK9 SCARB1 GATA2 RXFP1

2.16e-04193684ff6e6b825d6c88148216c601580be3c28851ab5c
ToppCellfacs-MAT-Fat-24m-Endothelial|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK9 SCARB1 GATA2 PAQR5

2.16e-04193684737e540c72a3cfe8dbd4c0f139f7d729a166793a
ToppCellPCW_13-14-Endothelial-Endothelial_mature-endo_capillary_(2)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

DOCK9 GATA2 AHR RXFP1

2.20e-041946843c31ac44e8cf4eca3ba7b8bfc05ad3e96a970956
ToppCellPCW_07-8.5-Endothelial-Endothelial_mature|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

DOCK9 GATA2 AHR RXFP1

2.20e-041946848c88a0ddd61ad900426e312ca4ab13061c0380b8
ToppCellLV-10._Endothelium_II|LV / Chamber and Cluster_Paper

ST6GALNAC3 DOCK9 GATA2 EXT1

2.20e-04194684b6cc849fa08599bff9839ef382d190cc964e273e
DrugGabapentin [60142-96-3]; Down 200; 23.4uM; MCF7; HT_HG-U133A

URB1 DNAJC16 PATZ1 KAT8 PPFIA3 VAV2 TBC1D17

2.31e-061986973472_DN
DrugIocetamic acid [16034-77-8]; Down 200; 6.6uM; HL60; HT_HG-U133A

CXCR3 DNAJC16 DOCK9 SCARB1 GATA4 APBA3 VAV2

2.31e-061986973022_DN
Drug3-nitroperylene

KAT8 AHR

9.05e-062692CID000062743
Diseasemastitis (biomarker_via_orthology)

TLR4 TLR9

5.08e-062672DOID:10690 (biomarker_via_orthology)
DiseaseCardiovascular Abnormalities

KAT8 GATA2 DDX6

6.13e-0616673C0243050
DiseasePneumonia

CCR2 CXCR3 TLR4 AHR

7.05e-0654674C0032285
DiseasePneumonitis

CCR2 CXCR3 TLR4 AHR

7.05e-0654674C3714636
DiseaseLobar Pneumonia

CCR2 CXCR3 TLR4 AHR

7.05e-0654674C0032300
DiseaseExperimental Lung Inflammation

CCR2 CXCR3 TLR4 AHR

7.05e-0654674C0887898
Diseasedermatomyositis (is_marker_for)

CCR2 TLR4 TLR9

7.44e-0617673DOID:10223 (is_marker_for)
DiseaseLong Qt Syndrome 2

ALG10 ALG10B

1.52e-053672C3150943
Diseasealcoholic pancreatitis

DNAJC16 TTC12 TRPV6 MBOAT2

7.47e-0598674EFO_1002013
Diseasenonsyndromic deafness (implicated_via_orthology)

ALG10 ALG10B

7.57e-056672DOID:0050563 (implicated_via_orthology)
Diseasesleep latency

MALRD1 CSNK2A2 CSMD1

8.23e-0537673EFO_0005280
Diseaseovarian cancer (implicated_via_orthology)

MSH6 POLE

1.41e-048672DOID:2394 (implicated_via_orthology)
DiseaseInflammation

CXCR3 TLR4 AHR TLR9

2.03e-04127674C0021368
Diseasecutaneous leishmaniasis (is_marker_for)

TLR4 TLR9

2.26e-0410672DOID:9111 (is_marker_for)
Diseaseallergic conjunctivitis (is_marker_for)

TLR4 TLR9

2.26e-0410672DOID:11204 (is_marker_for)
Diseasemismatch repair cancer syndrome (is_implicated_in)

MSH6 POLE

3.30e-0412672DOID:0112182 (is_implicated_in)
Diseaseasthma (is_implicated_in)

CCR2 CXCR3 TLR4 TLR9

4.56e-04157674DOID:2841 (is_implicated_in)
Diseasecircadian rhythm

DNAJC16 GATA4 CSMD1 ALG10B

5.25e-04163674EFO_0004354
DiseaseContact Dermatitis

CXCR3 TLR4 AHR

5.73e-0471673C0011616
DiseaseContact hypersensitivity

CXCR3 TLR4 AHR

5.73e-0471673C0162351
Diseaseresponse to triptolide, cytotoxicity measurement

PPIL3 CSMD1

5.97e-0416672EFO_0006952, EFO_0007662
Diseaseallergic rhinitis (is_marker_for)

TLR4 TLR9

6.76e-0417672DOID:4481 (is_marker_for)
Diseaseperinatal necrotizing enterocolitis (biomarker_via_orthology)

TLR4 TLR9

6.76e-0417672DOID:8677 (biomarker_via_orthology)
DiseaseMalignant neoplasm of endometrium

MSH6 POLE

7.59e-0418672C0007103
Diseasesinusitis (is_marker_for)

TLR4 TLR9

7.59e-0418672DOID:0050127 (is_marker_for)
DiseaseCarcinoma in situ of endometrium

MSH6 POLE

7.59e-0418672C0346191
Diseaseleptin measurement

LEKR1 ALG10 ALG10B

8.41e-0481673EFO_0005000
DiseaseLung Injury

TLR4 AHR

1.04e-0321672C0273115
DiseaseChronic Lung Injury

TLR4 AHR

1.04e-0321672C2350344
DiseaseColorectal Carcinoma

GMCL2 MSH6 POLE TLR4 GATA4 CCAR1 TLR9

1.06e-03702677C0009402
Diseaseamblyopia

MALRD1 TLR4

1.14e-0322672MONDO_0001020
DiseaseQRS duration, response to sulfonylurea

DOCK9 CSMD1

1.25e-0323672EFO_0005055, EFO_0007922
DiseaseBehcet Syndrome

TLR4 AHR

1.36e-0324672C0004943
Diseaseinterstitial lung disease (is_marker_for)

CCR2 TLR9

1.47e-0325672DOID:3082 (is_marker_for)
Diseaseacute necrotizing pancreatitis (biomarker_via_orthology)

TLR4 TLR9

1.59e-0326672DOID:0080998 (biomarker_via_orthology)
Diseaseanogenital venereal wart (is_marker_for)

TLR4 TLR9

1.59e-0326672DOID:11168 (is_marker_for)
Diseasepsychosis predisposition measurement

TMC7 CSMD1

1.59e-0326672EFO_0008337
DiseaseBMI-adjusted waist-hip ratio, sex interaction measurement, age at assessment

LEKR1 DCST2 CLOCK

1.78e-03105673EFO_0007788, EFO_0008007, EFO_0008343
Diseaseopioid dependence

TMC7 ST6GALNAC3 EXT1 CSMD1

2.09e-03237674EFO_0005611

Protein segments in the cluster

PeptideGeneStartEntry
GYQFIHAADMLYCAE

AHR

321

P35869
LGYMHCCLNPLLYAF

CXCR3

306

P49682
AAYNSLMDKHLAGYF

ERICH3

11

Q5RHP9
QLGYSCFYIHAKMRQ

DDX6

356

P26196
LHGCNSKKAYFLYMY

CDC23

106

Q9UJX2
MSILYHCKKGFYLLG

CSMD1

2821

Q96PZ7
LMAFVYFDQSHCGYL

CCAR1

926

Q8IX12
YKMLCHVFYAEDAQL

APBA3

326

O96018
HYAAMGGFADCCKYI

ANKEF1

256

Q9NU02
LFAYLMCLYGNHKTS

ALG10B

161

Q5I7T1
YFNYHDVGICKAVAM

SDHD

141

O14521
LHKIYLCQSGYFSSM

GMCL1

121

Q96IK5
SMSKNARHICYFLDY

PAQR5

106

Q9NXK6
CLRFHYAIYGFLKMS

MAMDC2

411

Q7Z304
MVGNCGLLYLIHYED

OR52N4

41

Q8NGI2
YCGVSYLILHEFKAM

LEKR1

26

Q6ZMV7
ENMHNYCFVFALGYL

MBOAT2

96

Q6ZWT7
FDLMYIGGKYQCHDI

NPNT

201

Q6UXI9
YMKYEKSYRFHLGQC

KAT8

216

Q9H7Z6
SLHYGIMCLKRLNYD

PPFIA3

1006

O75145
GYVLALNGHKKYFCL

DNAJC16

696

Q9Y2G8
NFYYTGKLHVMEELC

KCNS3

81

Q9BQ31
LAHKCILNSFYGYVM

POLE

806

Q07864
MRHICYFLDYGALSL

PAQR6

111

Q6TCH4
KGCYKFLMYFLLASN

OR9G9

191

P0C7N8
CYKVGKFYELYHMDA

MSH6

426

P52701
QVCGKYLRAAYMADH

PATZ1

471

Q9HBE1
NCKIIFHYHMYGNGI

MALRD1

1381

Q5VYJ5
TGHYLCNACGLYHKM

GATA2

311

P23769
YLCNACGLYHKMNGI

GATA4

236

P43694
YARCFHKMISYNGKL

KLHL15

476

Q96M94
CLHQFQYMGKRYIAR

DOCK9

1341

Q9BZ29
KYDYREMLHNATFCL

EXT1

321

Q16394
AMCKLFTGLYHIGYF

CCR2

111

P41597
FYMYELLKALDYCHS

CSNK2A2

136

P19784
MGLVNAYSHKFIKYC

DNAH14

676

Q0VDD8
QAYHLCYVLMPFKLA

DCST2

226

Q5T1A1
ECFLLAAMAYDHYVA

OR5T3

141

Q8NGG3
DCLAQMYFHLFYGVL

OR1E3

96

Q8WZA6
NKCFLLTAMGYDHYV

OR10J4

111

P0C629
LMLACYAGHLDVVKY

FANK1

181

Q8TC84
FYEHLNQMVKHCYLG

RTTN

1486

Q86VV8
KCYNIELMLFYRQHF

IL1RAPL2

376

Q9NP60
LHKIYLCQSGYFSSM

GMCL2

121

Q8NEA9
TFLLAMDACYGIHVY

ST6GALNAC3

221

Q8NDV1
MKNLSHIYFKNFRYC

RXFP2

376

Q8WXD0
MHYAQYVLLALGCVL

SCARB1

441

Q8WTV0
DLLVKYLYLCVFHMQ

PRORP

176

O15091
CSYMGHFDLLNYFAI

SF3B5

41

Q9BWJ5
HMKLICESLYASGYR

URB1

131

O60287
LFAYLMCLYGNHKTS

ALG10

161

Q5BKT4
EHLMQYGKGKSCYYR

CLOCK

326

O15516
KHQLMEFRCIAAYLY

CLTCL1

1501

P53675
NDILLTYCMYHFDLG

TBC1D17

401

Q9HA65
HYFVELLSHMCGLFY

TRAM1L1

226

Q8N609
LHALRFLFMDGNCYY

TLR9

166

Q9NR96
GCAHLENYALKMFLY

VTA1

86

Q9NP79
MYAYLLFKECDHSNN

PLCD3

221

Q8N3E9
YYNGCIFHRNIKGFM

PPIL3

36

Q9H2H8
VLASCSMYFHLFYKD

ZBTB18

41

Q99592
FACQMYNLLLSYDRH

TRPV6

251

Q9H1D0
LMNLSHIYFKKFQYC

RXFP1

366

Q9HBX9
FYMLHCGTALYNNLL

SRRD

216

Q9UH36
KLCHLYQDHMQYIGE

WNT5A

81

P41221
VQYSYSLFHLMLCLA

SERINC3

401

Q13530
AYFHMGKANLALKNY

TTC12

176

Q9H892
MADLCFLVQHYDLAY

TRAPPC8

426

Q9Y2L5
FKERLLIYGEYCSHM

VAV2

276

P52735
VYKFYFHLMLLAGCI

TLR4

651

O00206
CLIMFYFIALAGAHK

TMC7

676

Q7Z402