Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	calcium-dependent protein binding	GRM4 DMBT1	4.71e-03	98	21	2	GO:0048306
GeneOntologyMolecularFunction	ATPase binding	SLC2A13 ZNHIT6	5.69e-03	108	21	2	GO:0051117
HumanPheno	Abnormal external nose morphology	MEGF8 PUS1 FBXO31 ARID2 TOE1 TBX4 DPF2	1.53e-04	916	9	7	HP:0010938
HumanPheno	Abnormal nasal tip morphology	FBXO31 ARID2 TOE1 TBX4 DPF2	2.38e-04	386	9	5	HP:0000436
HumanPheno	Hypoplastic fifth fingernail	ARID2 DPF2	2.50e-04	14	9	2	HP:0008398
HumanPheno	Abnormal eyebrow morphology	MEGF8 FBXO31 ARID2 TOE1 TBX4 DPF2	3.09e-04	674	9	6	HP:0000534
HumanPheno	Hypoplastic toenails	ARID2 TBX4 DPF2	3.15e-04	82	9	3	HP:0001800
HumanPheno	Prominent eyelashes	ARID2 DPF2	3.72e-04	17	9	2	HP:0011231
HumanPheno	Oral aversion	ARID2 DPF2	3.72e-04	17	9	2	HP:0012523
Domain	Laminin_EGF	MEGF8 MEGF11	7.01e-04	35	21	2	PF00053
Domain	EGF_Lam	MEGF8 MEGF11	7.01e-04	35	21	2	SM00180
Domain	Laminin_EGF	MEGF8 MEGF11	8.26e-04	38	21	2	IPR002049
Domain	F-box-like	FBXO31 FBXO39	1.11e-03	44	21	2	PF12937
Domain	PSI	MEGF8 SLC2A13	1.21e-03	46	21	2	SM00423
Domain	CUB	MEGF8 DMBT1	1.37e-03	49	21	2	PF00431
Domain	CUB	MEGF8 DMBT1	1.43e-03	50	21	2	SM00042
Domain	-	MEGF8 DMBT1	1.54e-03	52	21	2	2.60.120.290
Domain	FBOX	FBXO31 FBXO39	1.54e-03	52	21	2	SM00256
Domain	CUB	MEGF8 DMBT1	1.60e-03	53	21	2	PS01180
Domain	p53-like_TF_DNA-bd	TOE1 TBX4	1.60e-03	53	21	2	IPR008967
Domain	CUB_dom	MEGF8 DMBT1	1.85e-03	57	21	2	IPR000859
Domain	F-box	FBXO31 FBXO39	2.55e-03	67	21	2	PF00646
Domain	FBOX	FBXO31 FBXO39	2.94e-03	72	21	2	PS50181
Domain	F-box_dom	FBXO31 FBXO39	3.18e-03	75	21	2	IPR001810
Pubmed	Coffin-Siris Syndrome	ARID2 DPF2	1.37e-05	9	22	2	23556151
Pubmed	Requirement for fibroblast growth factor 10 or fibroblast growth factor receptor 2-IIIb signaling for cecal development in mouse.	FGF7 TBX4	1.71e-05	10	22	2	14697353
Pubmed	Requirement for PBAF in transcriptional repression and repair at DNA breaks in actively transcribed regions of chromatin.	ARID2 DPF2	6.49e-05	19	22	2	25066234
Pubmed	BRD7, a novel PBAF-specific SWI/SNF subunit, is required for target gene activation and repression in embryonic stem cells.	ARID2 DPF2	6.49e-05	19	22	2	18809673
Pubmed	Spontaneous development of hepatocellular carcinoma with cancer stem cell properties in PR-SET7-deficient livers.	FGF7 TWF1	6.49e-05	19	22	2	25515659
Pubmed	Discovery of six new susceptibility loci and analysis of pleiotropic effects in leprosy.	CYLD SLC2A13	8.76e-05	22	22	2	25642632
Pubmed	Diversity and specialization of mammalian SWI/SNF complexes.	ARID2 DPF2	9.59e-05	23	22	2	8804307
Pubmed	FET family fusion oncoproteins target the SWI/SNF chromatin remodeling complex.	ARID2 DPF2	9.59e-05	23	22	2	30962207
Pubmed	The SWI/SNF chromatin-remodeling factor stimulates repair by human excision nuclease in the mononucleosome core particle.	ARID2 DPF2	1.05e-04	24	22	2	12215535
Pubmed	SWI/SNF chromatin remodeling and cancer.	ARID2 DPF2	1.05e-04	24	22	2	11790558
Pubmed	Reconstitution of a core chromatin remodeling complex from SWI/SNF subunits.	ARID2 DPF2	1.05e-04	24	22	2	10078207
Pubmed	Exit from G1 and S phase of the cell cycle is regulated by repressor complexes containing HDAC-Rb-hSWI/SNF and Rb-hSWI/SNF.	ARID2 DPF2	1.23e-04	26	22	2	10778858
Pubmed	Glioma tumor suppressor candidate region gene 1 (GLTSCR1) and its paralog GLTSCR1-like form SWI/SNF chromatin remodeling subcomplexes.	ARID2 DPF2	1.33e-04	27	22	2	29374058
Pubmed	REST repression of neuronal genes requires components of the hSWI.SNF complex.	ARID2 DPF2	1.43e-04	28	22	2	12192000
Pubmed	Aerobic glycolysis tunes YAP/TAZ transcriptional activity.	CAD DPF2 TWF1	1.43e-04	162	22	3	25796446
Pubmed	An embryonic stem cell chromatin remodeling complex, esBAF, is essential for embryonic stem cell self-renewal and pluripotency.	ARID2 DPF2	1.53e-04	29	22	2	19279220
Pubmed	RNF138 inhibits late inflammatory gene transcription through degradation of SMARCC1 of the SWI/SNF complex.	ARID2 CAD	1.53e-04	29	22	2	36800290
Pubmed	Mammalian SWI/SNF collaborates with a polycomb-associated protein to regulate male germline transcription in the mouse.	ARID2 DPF2	1.64e-04	30	22	2	31043422
Pubmed	The core SWI/SNF catalytic subunit Brg1 regulates nephron progenitor cell proliferation and differentiation.	ARID2 DPF2	2.24e-04	35	22	2	32504627
Pubmed	Analysis of the SWI/SNF chromatin-remodeling complex during early heart development and BAF250a repression cardiac gene transcription during P19 cell differentiation.	ARID2 DPF2	2.51e-04	37	22	2	24335282
Pubmed	TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1.	TOE1 CAD ZNHIT6 DMBT1 TWF1	2.68e-04	949	22	5	36574265
Pubmed	In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators.	TTC1 CAD ZNHIT6 DPF2 ZNF503	2.98e-04	971	22	5	33306668
Pubmed	Interactome analyses revealed that the U1 snRNP machinery overlaps extensively with the RNAP II machinery and contains multiple ALS/SMA-causative proteins.	ARID2 TOE1 CAD	4.76e-04	244	22	3	29884807
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	MEGF8 ARID2 TBX4 DPF2	6.31e-04	638	22	4	31182584
Cytoband	12q12	ARID2 SLC2A13 TWF1	1.53e-06	47	22	3	12q12
Cytoband	Ensembl 112 genes in cytogenetic band chr12q12	ARID2 SLC2A13 TWF1	3.72e-06	63	22	3	chr12q12
GeneFamily	Cyclins\|F-boxes other	FBXO31 FBXO39	4.68e-04	39	15	2	560
Computational	Neighborhood of DPF2	TTC1 GRM4 DPF2	5.18e-06	32	12	3	GCM_DPF2
Computational	Neighborhood of BNIP1	TTC1 GRM4 DPF2	7.72e-05	78	12	3	GCM_BNIP1
Computational	Neighborhood of RING1	TTC1 GRM4 DPF2	2.26e-04	112	12	3	GCM_RING1
Computational	Neighborhood of FANCC	TTC1 GRM4 DPF2	3.20e-04	126	12	3	GCM_FANCC
Computational	Neighborhood of PRKAG1	GRM4 DPF2	1.36e-03	50	12	2	GCM_PRKAG1
Computational	Neighborhood of SUPT4H1	GRM4 DPF2	1.82e-03	58	12	2	GCM_SUPT4H1
Computational	Genes in the cancer module 12.	GRM4 CAD DPF2 DMBT1	1.95e-03	519	12	4	MODULE_13
Computational	Neighborhood of BECN1	TTC1 GRM4	2.50e-03	68	12	2	GCM_BECN1
Drug	I pN	FGF7 DPF2 DMBT1	9.42e-06	43	22	3	CID000012276
Disease	Coffin-Siris syndrome	ARID2 DPF2	4.12e-05	13	22	2	C0265338
Disease	leprosy	CYLD SLC2A13	2.66e-03	103	22	2	EFO_0001054

Protein segments in the cluster

Peptide	Gene	Start	Entry
QVDRYTCKTCPYDMR	GRM4	551	Q14833
PDCSVSRAEMYSEYL	ARID2	536	Q68CP9
MYRRRSQCCPGYYES	MEGF11	81	A6BM72
NEDYPRTCRMCFYGT	FBXO31	456	Q5XUX0
ISLRSCYFSDPDCSM	FBXO39	311	Q8N4B4
YCSMYTDHSVCSRDP	MEGF8	561	Q7Z7M0
TYCTRQETYMHLCPD	DEFB124	36	Q8NES8
EEAKYRCPRCMRYSC	ZNHIT6	226	Q9NWK9
MYECRECYDDPDISA	CYLD	796	Q9NQC7
CSSPERHTRSYDYME	FGF7	46	P21781
KMVVCRAYDPSSRCY	DMBT1	2361	Q9UGM3
CTRYSYCNECMLDPD	SLC2A13	436	Q96QE2
DRCYSTPSMYCELRD	NBPF8	846	Q3BBV2
DPSACRYILEMYCEE	PUS1	256	Q9Y606
VMSYDRYATICCPLR	OR6J1	116	Q8NGC5
DDCDRGYHMYCLTPS	DPF2	346	Q92785
PETVSTDYDMCDRLY	CAD	976	P27708
VMTASLCRDPYCLSY	ZNF503	421	Q96F45
SYCSEVTPREACMYS	TBX4	381	P57082
ESSYSRALEMCPSCF	TTC1	136	Q99614
CNYPSSMRDHIDYRC	TOE1	271	Q96GM8
GYTCSIRERMLYSSC	TWF1	261	Q12792