Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionstructural constituent of postsynapse

POTEE POTEF POTEI SHANK3

1.51e-0632534GO:0099186
GeneOntologyMolecularFunctionstructural constituent of postsynaptic actin cytoskeleton

POTEE POTEF POTEI

2.87e-0611533GO:0098973
GeneOntologyMolecularFunctionstructural constituent of synapse

POTEE POTEF POTEI SHANK3

4.59e-0642534GO:0098918
GeneOntologyMolecularFunctionnerve growth factor binding

FURIN PCSK6

1.92e-048532GO:0048406
GeneOntologyMolecularFunctionneurotrophin binding

FURIN PCSK6

4.49e-0412532GO:0043121
GeneOntologyBiologicalProcessnerve growth factor production

FURIN PCSK6

1.94e-053532GO:0032902
GeneOntologyBiologicalProcesspostsynaptic actin cytoskeleton organization

POTEE POTEF POTEI

6.84e-0531533GO:0098974
GeneOntologyBiologicalProcessneurotrophin production

FURIN PCSK6

9.65e-056532GO:0032898
GeneOntologyBiologicalProcesspostsynaptic cytoskeleton organization

POTEE POTEF POTEI

9.89e-0535533GO:0099188
GeneOntologyCellularComponentNuA4 histone acetyltransferase complex

POTEE POTEF POTEI

7.25e-0532533GO:0035267
GeneOntologyCellularComponentH4/H2A histone acetyltransferase complex

POTEE POTEF POTEI

7.25e-0532533GO:0043189
GeneOntologyCellularComponentH4 histone acetyltransferase complex

POTEE POTEF POTEI

2.03e-0445533GO:1902562
DomainPDEase_PDE8

PDE8A PDE8B

7.31e-062512IPR013938
DomainActin_CS

POTEE POTEF POTEI

1.05e-0516513IPR004001
DomainACTINS_2

POTEE POTEF POTEI

1.27e-0517513PS00432
DomainActin/actin-like_CS

POTEE POTEF POTEI

1.52e-0518513IPR020902
DomainACTINS_ACT_LIKE

POTEE POTEF POTEI

1.80e-0519513PS01132
DomainAnk_2

POTEE POTEM POTEF POTEG POTEI SHANK3

2.54e-05215516PF12796
Domain-

POTEE POTEM POTEF POTEG POTEI SHANK3

5.63e-052485161.25.40.20
DomainANK

POTEE POTEM POTEF POTEG POTEI SHANK3

6.02e-05251516SM00248
DomainANK_REPEAT

POTEE POTEM POTEF POTEG POTEI SHANK3

6.29e-05253516PS50088
DomainAnkyrin_rpt-contain_dom

POTEE POTEM POTEF POTEG POTEI SHANK3

6.43e-05254516IPR020683
DomainANK_REP_REGION

POTEE POTEM POTEF POTEG POTEI SHANK3

6.43e-05254516PS50297
DomainAnkyrin_rpt

POTEE POTEM POTEF POTEG POTEI SHANK3

7.63e-05262516IPR002110
DomainActin

POTEE POTEF POTEI

8.17e-0531513IPR004000
DomainActin

POTEE POTEF POTEI

8.17e-0531513PF00022
DomainACTIN

POTEE POTEF POTEI

8.17e-0531513SM00268
DomainPeptidase_S8_Asp-AS

FURIN PCSK6

1.09e-046512IPR023827
DomainSAM_DOMAIN

SAMD9L SAMD7 SAMSN1 SHANK3

1.31e-0495514PS50105
DomainSAM

SAMD9L SAMD7 SAMSN1 SHANK3

1.42e-0497514IPR001660
DomainPrprotnconvertsP

FURIN PCSK6

1.52e-047512IPR002884
DomainP_proprotein

FURIN PCSK6

1.52e-047512PF01483
DomainS8_pro-domain

FURIN PCSK6

1.52e-047512IPR032815
Domain-

FURIN PCSK6

1.52e-0475123.30.70.850
DomainS8_pro-domain

FURIN PCSK6

1.52e-047512PF16470
Domain-

SAMD9L SAMD7 SAMSN1 SHANK3

1.99e-041065141.10.150.50
DomainPeptidase_S8_His-AS

FURIN PCSK6

2.60e-049512IPR022398
DomainPeptidase_S8_Ser-AS

FURIN PCSK6

2.60e-049512IPR023828
DomainSAM/pointed

SAMD9L SAMD7 SAMSN1 SHANK3

2.91e-04117514IPR013761
DomainPeptidase_S8_subtilisin-rel

FURIN PCSK6

3.24e-0410512IPR015500
DomainSUBTILASE_ASP

FURIN PCSK6

3.24e-0410512PS00136
DomainSUBTILASE_HIS

FURIN PCSK6

3.24e-0410512PS00137
DomainSUBTILASE_SER

FURIN PCSK6

3.24e-0410512PS00138
DomainAnk

POTEE POTEM POTEF POTEG POTEI

3.86e-04228515PF00023
Domain-

FURIN PCSK6

3.96e-04115123.40.50.200
DomainPeptidase_S8/S53_dom

FURIN PCSK6

3.96e-0411512IPR000209
DomainPeptidase_S8

FURIN PCSK6

3.96e-0411512PF00082
DomainPropept_inh

FURIN PCSK6

9.68e-0417512IPR009020
DomainFurin_repeat

FURIN PCSK6

1.09e-0318512IPR006212
DomainFU

FURIN PCSK6

1.09e-0318512SM00261
DomainPLAC

ADAMTS7 PCSK6

1.21e-0319512PS50900
DomainPLAC

ADAMTS7 PCSK6

1.21e-0319512IPR010909
DomainPDEase

PDE8A PDE8B

1.21e-0319512IPR023088
DomainPDEase_I

PDE8A PDE8B

1.49e-0321512PF00233
DomainPDEASE_I

PDE8A PDE8B

1.49e-0321512PS00126
DomainPDEase_CS

PDE8A PDE8B

1.49e-0321512IPR023174
Domain-

PDE8A PDE8B

1.63e-03225121.10.1300.10
DomainPDEase_catalytic_dom

PDE8A PDE8B

1.78e-0323512IPR002073
DomainSAM

SAMD7 SAMSN1 SHANK3

1.79e-0388513SM00454
DomainHDc

PDE8A PDE8B

1.94e-0324512SM00471
DomainHD/PDEase_dom

PDE8A PDE8B

1.94e-0324512IPR003607
DomainPAS

PDE8A PDE8B

2.11e-0325512PF00989
DomainPAS_fold

PDE8A PDE8B

2.11e-0325512IPR013767
DomainIg_E-set

ARHGDIA SAG NFATC2

2.88e-03104513IPR014756
DomainPAS

PDE8A PDE8B

3.44e-0332512SM00091
DomainPAS

PDE8A PDE8B

3.88e-0334512IPR000014
DomainPAS

PDE8A PDE8B

3.88e-0334512PS50112
Pubmed

Identification of a novel actin isoform in hepatocellular carcinoma.

POTEE POTEM POTEF POTEG POTEI

2.01e-111553516824795
Pubmed

The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells.

HDAC3 ZNF384 TSHZ3 INTS14 MDN1 POLR2C TNPO3

2.40e-0728253723667531
Pubmed

Duplication and extensive remodeling shaped POTE family genes encoding proteins containing ankyrin repeat and coiled coil domains.

POTEE POTEM POTEI

2.79e-07953316364570
Pubmed

cAMP-specific phosphodiesterases 8A and 8B, essential regulators of Leydig cell steroidogenesis.

PDE8A PDE8B

2.28e-06253222232524
Pubmed

The high-affinity cAMP-specific phosphodiesterase 8B controls steroidogenesis in the mouse adrenal gland.

PDE8A PDE8B

2.28e-06253221187369
Pubmed

Opposing function of the proprotein convertases furin and PACE4 on breast cancer cells' malignant phenotypes: role of tissue inhibitors of metalloproteinase-1.

FURIN PCSK6

2.28e-06253217909005
Pubmed

A primate-specific POTE-actin fusion protein plays a role in apoptosis.

POTEE POTEF

2.28e-06253219669888
Pubmed

Enhanced UV-induced skin carcinogenesis in transgenic mice overexpressing proprotein convertases.

FURIN PCSK6

2.28e-06253223441131
Pubmed

Identification of a second human subtilisin-like protease gene in the fes/fps region of chromosome 15.

FURIN PCSK6

2.28e-0625321741956
Pubmed

Comparison of enzymatic characterization and gene organization of cyclic nucleotide phosphodiesterase 8 family in humans.

PDE8A PDE8B

2.28e-06253212681444
Pubmed

cAMP-specific phosphodiesterase 8A and 8B isoforms are differentially expressed in human testis and Leydig cell tumor.

PDE8A PDE8B

2.28e-06253236277728
Pubmed

Two-Dimensional Fractionation Method for Proteome-Wide Cross-Linking Mass Spectrometry Analysis.

CKM ARHGDIA MDN1 HSPH1 MRPL30 NAP1L1 RCN1 DNAJC5 DNMT1

4.90e-0684753935235311
Pubmed

The Vertebrate Genome Annotation browser 10 years on.

POTEE POTEM POTEF POTEG POTEI

5.09e-0616353524316575
Pubmed

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.

DDX19B HDAC3 ZNF384 ARHGDIA THYN1 HSPH1 NAP1L1 TNPO3 HEXIM1 DNMT1

5.58e-061103531034189442
Pubmed

Comparative cellular processing of the human immunodeficiency virus (HIV-1) envelope glycoprotein gp160 by the mammalian subtilisin/kexin-like convertases.

FURIN PCSK6

6.83e-0635328670066
Pubmed

Evolution and expression of chimeric POTE-actin genes in the human genome.

POTEE POTEF

6.83e-06353217101985
Pubmed

Subtilisin-like proprotein convertases, PACE4 and PC8, as well as furin, are endogenous proalbumin convertases in HepG2 cells.

FURIN PCSK6

6.83e-06353210050053
Pubmed

CDMP1/GDF5 has specific processing requirements that restrict its action to joint surfaces.

FURIN PCSK6

1.36e-05453216829522
Pubmed

Cellular processing of the nerve growth factor precursor by the mammalian pro-protein convertases.

FURIN PCSK6

1.36e-0545328615794
Pubmed

Neurotrophin secretion: current facts and future prospects.

FURIN PCSK6

1.36e-05453212787574
Pubmed

Neuroinflammation-Induced Interactions between Protease-Activated Receptor 1 and Proprotein Convertases in HIV-Associated Neurocognitive Disorder.

FURIN PCSK6

1.36e-05453226283733
Pubmed

The proprotein convertases furin and PACE4 play a significant role in tumor progression.

FURIN PCSK6

1.36e-05453210900462
Pubmed

Retroviral envelope glycoprotein processing: structural investigation of the cleavage site.

FURIN PCSK6

1.36e-0545329521771
Pubmed

E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.

POTEE SAMD9L MDN1 THYN1 PI4KA HSPH1 ZNF622 PBX4

1.48e-0573653829676528
Pubmed

Cripto recruits Furin and PACE4 and controls Nodal trafficking during proteolytic maturation.

FURIN PCSK6

2.27e-05553218772886
Pubmed

Regulation of prohepcidin processing and activity by the subtilisin-like proprotein convertases Furin, PC5, PACE4 and PC7.

FURIN PCSK6

2.27e-05553218664504
Pubmed

Processing of prothyrotropin-releasing hormone by the family of prohormone convertases.

FURIN PCSK6

2.27e-0555329242664
Pubmed

Proprotein convertase expression and localization in epidermis: evidence for multiple roles and substrates.

FURIN PCSK6

2.27e-05553211380615
Pubmed

The new enzymology of precursor processing endoproteases.

FURIN PCSK6

2.27e-0555321429684
Pubmed

Deployment of the human immunodeficiency virus type 1 protein arsenal: combating the host to enhance viral transcription and providing targets for therapeutic development.

NFATC2 POLR2C HEXIM1

2.30e-053653322422068
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

ZNF384 ARHGDIA MDN1 PI4KA ACO2 HSPH1 POLR2C NAP1L1 LARP4 DNMT1

3.26e-051353531029467282
Pubmed

Identification of the paired basic convertases implicated in HIV gp160 processing based on in vitro assays and expression in CD4(+) cell lines.

FURIN PCSK6

3.40e-0565328940009
Pubmed

Two novel transcripts encoding two Ankyrin repeat containing proteins have preponderant expression during the mouse spermatogenesis.

POTEM POTEG

3.40e-05653217171436
Pubmed

Murine subtilisin-like proteinase SPC6 is expressed during embryonic implantation, somitogenesis, and skeletal formation.

FURIN PCSK6

3.40e-0565329291583
Pubmed

Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.

SLC7A6OS HSPH1 POLR2C CAST NAP1L1 RCN1 ZNF622 LARP4 HEXIM1 DNMT1

4.75e-051415531028515276
Pubmed

Five POTE paralogs and their splice variants are expressed in human prostate and encode proteins of different lengths.

POTEE POTEG

4.76e-05753215276201
Pubmed

HDAC2/3 binding and deacetylation of BubR1 initiates spindle assembly checkpoint silencing.

HDAC3 BRCA2

4.76e-05753228985013
Pubmed

Proteolytic processing in the secretory pathway.

FURIN PCSK6

4.76e-05753210409610
Pubmed

The family of subtilisin/kexin like pro-protein and pro-hormone convertases: divergent or shared functions.

FURIN PCSK6

4.76e-0575327819324
Pubmed

Nodal protein processing and fibroblast growth factor 4 synergize to maintain a trophoblast stem cell microenvironment.

FURIN PCSK6

4.76e-05753215505202
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

POTEE MDN1 POTEF ACO2 CTAGE1 HSPH1 RCN1 DNAJC5 POTEI DYNC1I1

5.57e-051442531035575683
Pubmed

Chromosomal assignment of the genes for proprotein convertases PC4, PC5, and PACE 4 in mouse and human.

FURIN PCSK6

6.34e-0585327782070
Pubmed

Regulation of bone morphogenetic protein activity by pro domains and proprotein convertases.

FURIN PCSK6

6.34e-0585329885250
Pubmed

Cellular localization and role of prohormone convertases in the processing of pro-melanin concentrating hormone in mammals.

FURIN PCSK6

6.34e-05853210037747
Pubmed

A High-Density Human Mitochondrial Proximity Interaction Network.

DDX19B POTEE HDAC3 NDUFB11 MDN1 PI4KA ACO2 MRPL30 ZNF622 LARP4

7.57e-051496531032877691
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

POTEE HDAC3 MDN1 NFATC2 PI4KA HSPH1 POLR2C NAP1L1 ZNF622 HEXIM1

7.61e-051497531031527615
Pubmed

CCT3 acts upstream of YAP and TFCP2 as a potential target and tumour biomarker in liver cancer.

POTEE POTEF HSPH1 NAP1L1 POTEI

7.80e-0528853531501420
Pubmed

The effects of trichostatin A on mRNA expression of chromatin structure-, DNA methylation-, and development-related genes in cloned mouse blastocysts.

HDAC3 DNMT1

8.15e-05953218241125
Pubmed

The activation and physiological functions of the proprotein convertases.

FURIN PCSK6

8.15e-05953218343183
Pubmed

The prohormone theory and the proprotein convertases: it is all about serendipity.

FURIN PCSK6

8.15e-05953221805236
Pubmed

The proprotein convertases, 20 years later.

FURIN PCSK6

8.15e-05953221805237
Pubmed

The biology and therapeutic targeting of the proprotein convertases.

FURIN PCSK6

8.15e-05953222679642
Pubmed

The multifaceted proprotein convertases: their unique, redundant, complementary, and opposite functions.

FURIN PCSK6

8.15e-05953223775089
Pubmed

SPC4, SPC6, and the novel protease SPC7 are coexpressed with bone morphogenetic proteins at distinct sites during embryogenesis.

FURIN PCSK6

8.15e-0595328698813
Pubmed

Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15.

ARHGDIA ACO2 HSPH1 NAP1L1 RCN1 LARP4 TNPO3

1.01e-0471453728302793
Pubmed

Expression and transient nuclear translocation of proprotein convertase 1 (PC1) during mouse preimplantation embryonic development.

FURIN PCSK6

1.02e-041053216163737
Pubmed

PC7 and the related proteases Furin and Pace4 regulate E-cadherin function during blastocyst formation.

FURIN PCSK6

1.02e-041053226416966
Pubmed

Nfix regulates fetal-specific transcription in developing skeletal muscle.

CKM NFIA

1.24e-041153220178747
Pubmed

Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.

ZNF384 ARHGDIA INTS14 MDN1 FURIN RCN1 S1PR1 DYNC1I1 REV1

1.34e-04129353915342556
Pubmed

Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.

CKM ARHGDIA HSPH1 POLR2C MRPL30 RCN1 LARP4 TNPO3 DNMT1

1.37e-04129753933545068
Pubmed

Optimized fragmentation schemes and data analysis strategies for proteome-wide cross-link identification.

MDN1 POTEF PI4KA HSPH1 CAST NAP1L1

1.65e-0453853628524877
Pubmed

Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair.

ARHGDIA TSHZ3 HSPH1 POLR2C MRPL30 NAP1L1 LARP4 TNPO3 HEXIM1

1.70e-04133553929229926
Pubmed

Complementary quantitative proteomics reveals that transcription factor AP-4 mediates E-box-dependent complex formation for transcriptional repression of HDM2.

THYN1 NFATC2 NFIA

2.26e-047753319505873
Pubmed

Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis.

PDE8A HSPH1 RCN1 TNPO3

2.26e-0419553417110338
Pubmed

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

POLR2C DNMT1

2.36e-041553221406692
Pubmed

Imaging proprotein convertase activities and their regulation in the implanting mouse blastocyst.

FURIN PCSK6

2.70e-041653220876279
Pubmed

Phosphoproteome analysis of functional mitochondria isolated from resting human muscle reveals extensive phosphorylation of inner membrane protein complexes and enzymes.

ACO2 DNAJC5 CASQ1

2.72e-048253320833797
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

ARHGDIA MDN1 PI4KA ACO2 HSPH1 NAP1L1 PEAK1 HEXIM1 DNMT1

2.76e-04142553930948266
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

NDUFB11 ARHGDIA PI4KA ACO2 HSPH1 NAP1L1 PEAK1 SHANK3 DYNC1I1

2.85e-04143153937142655
Pubmed

Identification of a USP9X Substrate NFX1-123 by SILAC-Based Quantitative Proteomics.

HSPH1 MRPL30 NAP1L1 LARP4 DNMT1

2.97e-0438453531059266
Pubmed

Hyperubiquitination of proteins in dilated cardiomyopathy.

CKM ACO2

3.05e-041753212601813
Pubmed

CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.

DDX19B HDAC3 MDN1 BRCA2 PI4KA POLR2C

3.13e-0460653636538041
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

DDX19B MDN1 POTEF PI4KA PEAK1 TNPO3 DNMT1

3.18e-0486153736931259
Pubmed

A high-throughput approach for measuring temporal changes in the interactome.

DDX19B HSPH1 POLR2C CAST NAP1L1 RCN1 ZNF622 TNPO3 HEXIM1

3.22e-04145553922863883
Pubmed

HectD1 controls hematopoietic stem cell regeneration by coordinating ribosome assembly and protein synthesis.

HSPH1 NAP1L1 ZNF622

3.24e-048753333711283
Pubmed

Cell-type-specific consequences of Reelin deficiency in the mouse neocortex, hippocampus, and amygdala.

NFIA PCSK6 RCN1

3.35e-048853321491433
Pubmed

WWP2 ubiquitylates RNA polymerase II for DNA-PK-dependent transcription arrest and repair at DNA breaks.

HSPH1 POLR2C NAP1L1 ZNF622 LARP4 HEXIM1

3.38e-0461553631048545
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

NDUFB11 MDN1 PI4KA HSPH1 RCN1 ZNF622 DNAJC5 PEAK1 DNMT1

3.77e-04148753933957083
Pubmed

Rho-associated protein kinase-dependent moesin phosphorylation is required for PD-L1 stabilization in breast cancer.

ARHGDIA HSPH1 TNPO3 DNMT1

3.83e-0422453432941674
Pubmed

Daxx Inhibits HIV-1 Reverse Transcription and Uncoating in a SUMO-Dependent Manner.

TNPO3 DNMT1

3.83e-041953232545337
Pubmed

The nodal precursor acting via activin receptors induces mesoderm by maintaining a source of its convertases and BMP4.

FURIN PCSK6

3.83e-041953216950123
Pubmed

A protein interaction landscape of breast cancer.

MDN1 BRCA2 PI4KA ACO2 HSPH1 TNPO3

3.98e-0463453634591612
Pubmed

Furin is the primary in vivo convertase of angiopoietin-like 3 and endothelial lipase in hepatocytes.

FURIN PCSK6

4.25e-042053223918928
Pubmed

Loss of the extraembryonic ectoderm in Elf5 mutants leads to defects in embryonic patterning.

FURIN PCSK6

4.25e-042053215829518
Pubmed

Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naïve to therapy.

POTEE POTEF POTEI

4.32e-049653323580065
Pubmed

∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis.

MDN1 HSPH1 CAST NAP1L1 RCN1 TNPO3

4.42e-0464753626618866
Pubmed

Extraembryonic proteases regulate Nodal signalling during gastrulation.

FURIN PCSK6

4.70e-042153212447384
Pubmed

Sall4 isoforms act during proximal-distal and anterior-posterior axis formation in the mouse embryo.

FURIN PCSK6

4.70e-042153218781635
Pubmed

CHFR regulates chemoresistance in triple-negative breast cancer through destabilizing ZEB1.

INTS14 HSPH1 NAP1L1

5.01e-0410153334462429
Pubmed

The microenvironment patterns the pluripotent mouse epiblast through paracrine Furin and Pace4 proteolytic activities.

FURIN PCSK6

5.16e-042253221896659
Pubmed

p16 Protein and gigaxonin are associated with the ubiquitination of NFκB in cisplatin-induced senescence of cancer cells.

POTEE REV1

5.16e-042253225331947
Pubmed

N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.

ZNF384 ARHGDIA HSPH1 CAST NAP1L1 ZNF622 DNMT1

5.18e-0493453733916271
Pubmed

Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

SAG POTEF MRPL30 POTEI REV1

5.63e-0444253515815621
Pubmed

Nuclear receptors TR2 and TR4 recruit multiple epigenetic transcriptional corepressors that associate specifically with the embryonic β-type globin promoters in differentiated adult erythroid cells.

HDAC3 DNMT1

5.65e-042353221670149
Pubmed

New insights into the control of HIV-1 transcription: when Tat meets the 7SK snRNP and super elongation complex (SEC).

POLR2C HEXIM1

5.65e-042353221360054
Pubmed

A Single Adaptable Cochaperone-Scaffold Complex Delivers Nascent Iron-Sulfur Clusters to Mammalian Respiratory Chain Complexes I-III.

NDUFB11 MDN1 ACO2 POLR2C ZNF622 TNPO3

6.02e-0468653628380382
Pubmed

Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy.

ARHGDIA SAMD9L PDE8A CAST CASQ1 SAMD7

6.02e-0468653629987050
Pubmed

Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping.

ACO2 SHANK3

6.16e-042453211258795
Pubmed

In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators.

CKM HSPH1 CAST NAP1L1 ZNF622 LARP4 DNMT1

6.52e-0497153733306668
Pubmed

Overview of PDEs and their regulation.

PDE8A PDE8B

6.68e-042553217307970
InteractionACTG2 interactions

POTEE POTEF POTEI HEXIM1

7.66e-0649524int:ACTG2
InteractionDNAJC7 interactions

MDN1 BRCA2 PI4KA HSPH1 DNAJC5 SHANK3 DYNC1I1 HEXIM1

1.22e-05425528int:DNAJC7
InteractionPFDN2 interactions

POTEE POTEF POLR2C POTEI LARP4 DYNC1I1

4.05e-05247526int:PFDN2
InteractionSOX2 interactions

HDAC3 ZNF384 ARHGDIA TSHZ3 INTS14 MDN1 NFIA PI4KA POLR2C NAP1L1 RCN1 PBX4 TNPO3

4.81e-0514225213int:SOX2
InteractionSLC25A11 interactions

ACO2 FURIN POLR2C POTEI SHANK3 HEXIM1

4.84e-05255526int:SLC25A11
Cytoband2q21.1

POTEE POTEF POTEI

4.29e-05585332q21.1
Cytoband13q12.3

BRCA2 HSPH1

2.98e-042253213q12.3
CytobandEnsembl 112 genes in cytogenetic band chr2q21

POTEE POTEF POTEI

7.24e-04151533chr2q21
GeneFamilyAnkyrin repeat domain containing|POTE ankyrin domain containing

POTEE POTEM POTEF POTEG POTEI

4.55e-1113395685
GeneFamilyAnkyrin repeat domain containing

POTEE POTEM POTEF POTEG POTEI SHANK3

1.22e-05242396403
GeneFamilySterile alpha motif domain containing

SAMD9L SAMD7 SAMSN1 SHANK3

3.78e-0588394760
GeneFamilyProprotein convertase subtilisin/kexin family

FURIN PCSK6

1.62e-049392973
GeneFamilyPhosphodiesterases

PDE8A PDE8B

1.21e-0324392681
CoexpressionLAKE_ADULT_KIDNEY_C22_ENDOTHELIAL_CELLS_GLOMERULAR_CAPILLARIES

PDE8A NFIA HSPH1 PEAK1 SHANK3

8.50e-06137535M39241
ToppCellTCGA-Brain-Primary_Tumor-Glioblastoma-Primary_GBM-11|TCGA-Brain / Sample_Type by Project: Shred V9

POTEE POTEF POTEG POTEI

9.71e-0763534d7dc1356a60cb527fe668328d5375f352239d911
ToppCellSmart-seq2-blood_(Smart-seq2)-hematologic-thrombocytic-platelet|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

POTEE POTEF PCSK6 POTEG POTEI

2.38e-06180535beb4d777e0c5fa0a59672dbc3dbb7732498605ff
ToppCellSmart-seq2-blood_(Smart-seq2)-hematologic-thrombocytic|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

POTEE POTEF PCSK6 POTEG POTEI

2.38e-06180535fb3d549c2a69b2157a486786ddd775ca16699ed0
ToppCellCOVID-19-kidney-T-cells-2|COVID-19 / Disease (COVID-19 only), tissue and cell type

SEMA4D NFATC2 HSPH1 PBX4 SAMSN1

2.95e-0618853515484c05cb496cd98ed3f79a6134c5cec8f09a4d
ToppCellParenchymal-10x3prime_v2-Immune_Lymphocytic-T-T_CD4-CD4_TRM/EMRA|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

SEMA4D HSPH1 PBX4 SAMSN1 HEXIM1

3.89e-061995355a29db2610ba06a2248325a16cad755d20debf2c
ToppCellTCGA-Breast-Primary_Tumor-Breast_Carcinoma-Infiltrating_Lobular_Carcinoma-9|TCGA-Breast / Sample_Type by Project: Shred V9

POTEE POTEM POTEF POTEI

4.07e-069053496e836c7a1df279ac812b7c3aa75e6b81b614244
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-mature_alpha-beta_T_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TSHZ3 SAG PI4KA PEAK1

2.21e-05138534321070b6900887b27da0f2b25808a05a8ab89ee7
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-BM_CD8_+_CD4_T_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TSHZ3 SAG PI4KA PEAK1

2.21e-0513853419ffd66256fa94d728138d37d0a5a3bac7722dbb
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Granulocytic|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SEMA4D ADAMTS7 CASQ1 SAMSN1

5.22e-051725343a37569a5902f3c65ff8d3912421309a8c82ee9b
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Granulocytic-Mast_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SEMA4D ADAMTS7 CASQ1 SAMSN1

5.22e-05172534cc9d9dae290f11f8c348c78228af4e49469dc93b
ToppCellsystemic_lupus_erythematosus-flare-Lymphocytic_B-plasmablast-male|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

POTEE SAG BRCA2 POTEM

6.09e-05179534021d782134126c6f7dce6b6ea50cc54bdaa39987
ToppCell(1)_B_cells-(1)_B_CD27pos|(1)_B_cells / Oesophagus cell shreds on cell class (v1) and cell subclass (v1)

HSPH1 NAP1L1 SAMSN1 HEXIM1

6.36e-05181534d2476956ca13f9234d7e77c3ee432dd54eebeac4
ToppCelldroplet-Marrow-nan-3m-Hematologic-megakaryocyte-erythroid_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SAMD9L PDE8A DNMT1 REV1

7.22e-0518753414c239af77116d28d511dea754b6150d20488080
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c07-AHNAK|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

ARHGDIA FURIN PBX4 SAMSN1

7.52e-05189534284f39dfacec76004daae9dd5317fb7b1f04fa99
ToppCellCOVID-19-lung-CD8+_T_cells|COVID-19 / Disease (COVID-19 only), tissue and cell type

SEMA4D NFATC2 PBX4 SAMSN1

7.83e-05191534543f8ae07cc2e6950c888115a5ca9445e3c0f618
ToppCellCOVID-19-kidney-T-cells-2|kidney / Disease (COVID-19 only), tissue and cell type

NFATC2 HSPH1 PBX4 SAMSN1

7.83e-05191534698e6a28276704f8baa082d028db2345b973c4bc
ToppCell5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_T/NK-CD4-positive,_alpha-beta_T_cell-CD4_T_cells-CD4_T_cells_L.1.1.1.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SEMA4D NFATC2 PBX4 SAMSN1

7.83e-0519153429ce21c6e810edd51f13e0fb1083cd44bd57b1d4
ToppCellCOVID-19-lung-CD4+_Treg|COVID-19 / Disease (COVID-19 only), tissue and cell type

SEMA4D NFATC2 PBX4 SAMSN1

7.83e-051915345a4ad5ae5c2dbfb225158cb598ef649c26a48350
ToppCellCOVID-19-lung-CD4+_Treg|lung / Disease (COVID-19 only), tissue and cell type

SEMA4D NFATC2 PBX4 SAMSN1

7.83e-0519153473ea3078c1f55cd47e4d99e77b3ce4ff17549d49
ToppCelldroplet-Thymus-nan-3m-Lymphocytic-DN_to_DP_transition,_dividing_(more_DN)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THYN1 BRCA2 HSPH1 DNMT1

8.15e-0519353440eedc1490c113403bc7c12a6bdf976f4f8bca84
ToppCellCOVID-19-lung-CD4+_T_cells_metabolically_active|COVID-19 / Disease (COVID-19 only), tissue and cell type

SEMA4D NFATC2 PBX4 SAMSN1

8.15e-05193534326fd2ce2c4b51e5a38f2a7a09f22f8f0e92735a
ToppCellTracheal-10x5prime-Immune_Lymphocytic-T-T_CD4-CD4_naive/CM|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

SEMA4D PBX4 SAMSN1 S1PR1

8.83e-05197534eebf4c3e71efc17672801649eed1bf158b2a88e5
ToppCellCD8+_Memory_T_cell-CV-3|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster

SEMA4D NFATC2 SAMSN1 DNMT1

8.83e-051975349fe3d53346a95c1bbb0fc6a2f2e974889873424b
ToppCellCV-Moderate-3|CV / Virus stimulation, Condition and Cluster

SEMA4D NFATC2 SAMSN1 DNMT1

8.83e-051975347031286e300eaccf73b927939f8de3a9d2d5fc74
ToppCellParenchymal-NucSeq-Immune_Lymphocytic-T-T_CD4-CD4_TRM/EMRA|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

NFATC2 HSPH1 PBX4 SAMSN1

9.00e-0519853490863377ed36afc30bc1a068612ad1adc77af5a8
ToppCellTracheal-NucSeq-Immune_Myeloid-Mast_cell-Mast_cell|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SEMA4D ADAMTS7 CASQ1 SAMSN1

9.00e-05198534cc5ca64749e2f4f1d373d9472824df85741702b7
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

MDN1 NFATC2 NAP1L1 PEAK1

9.00e-05198534a860246bcea847249a78fd2e86ed8e04371060db
ToppCellTracheal-NucSeq-Immune_Myeloid-Mast_cell|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SEMA4D ADAMTS7 CASQ1 SAMSN1

9.00e-05198534d4d66f19df078bfc3a83d4664aaf9c7789bde1a5
ToppCellParenchymal-NucSeq-Immune_Lymphocytic-T-T_CD4-CD4|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SEMA4D NFATC2 PBX4 SAMSN1

9.18e-05199534fbdde57dd88656621801e65ee2818251588f3874
ToppCellParenchymal-NucSeq-Immune_Lymphocytic-T-T_CD8-CD8|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SEMA4D NFATC2 PBX4 SAMSN1

9.18e-051995340d6463e368fd611a17327322413fad145f3c7f32
ToppCellParenchymal-NucSeq-Immune_Lymphocytic-T|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SEMA4D NFATC2 PBX4 SAMSN1

9.36e-05200534dfdfad881c114e1bc9a64b411e1b00fb37cc859b
ToppCellParenchymal-NucSeq-Immune_Lymphocytic-T-T_CD8-CD8_GZMK+|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SEMA4D NFATC2 PBX4 SAMSN1

9.36e-052005347a9c3f51d4a8fda5f1b7e0be6fcf9c1c92fffe99
ToppCellBronchial-NucSeq-Immune_Lymphocytic-T|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SEMA4D NFATC2 PBX4 SAMSN1

9.36e-05200534c6c2b39359c65c9444987d02d1c899dff2ad1366
ToppCellBronchial-NucSeq-Immune_Lymphocytic-T-T_CD4-CD4|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SEMA4D NFATC2 PBX4 SAMSN1

9.36e-052005348474e5d031d25bfb8461d39fa2053da01a6304fc
ToppCellParenchymal-NucSeq-Immune_Lymphocytic-T-T_CD8|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SEMA4D NFATC2 PBX4 SAMSN1

9.36e-0520053466fb892bda1d29e67a65717e85f2ec221f520b2a
ToppCellBronchial-NucSeq-Immune_Lymphocytic-T-T_CD8|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SEMA4D NFATC2 PBX4 SAMSN1

9.36e-0520053402c4169a23e5aaa0d4bfc78b51ba19ce8157dc3e
ToppCellTracheal-10x5prime-Immune_Myeloid-Mast_cell|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

POTEE ADAMTS7 CASQ1 SAMSN1

9.36e-05200534c3511607692e05f44538a376253673dd18f77908
ToppCellTracheal-NucSeq-Immune_Lymphocytic-T-T_CD8-CD8_CTL|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SEMA4D NFATC2 HSPH1 SAMSN1

9.36e-05200534893bb7c25ad7c6589a4c7c0364c2ace666e9b4be
ToppCellBronchial-NucSeq-Immune_Lymphocytic-T-T_CD4|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SEMA4D NFATC2 PBX4 SAMSN1

9.36e-052005349de4d6ebb7e9bee5d811519eb05913ef30f70786
ToppCellParenchymal-NucSeq-Immune_Lymphocytic-T-T_CD4|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SEMA4D NFATC2 PBX4 SAMSN1

9.36e-05200534f7a9d8b99de19e9842422bada348d940e0863645
ToppCellParenchymal-NucSeq-Immune_Lymphocytic-T-T_CD4-CD4_naive/CM|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SEMA4D NFATC2 PBX4 SAMSN1

9.36e-05200534cded40d5069a6fdbd90ac9a2a0bbef11727b28d5
ToppCellBronchial-NucSeq-Immune_Lymphocytic-T-T_CD8-CD8_GZMK+|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SEMA4D NFATC2 PBX4 SAMSN1

9.36e-05200534510d84bf7a4621b079e5a7330d25e04508c84a49
ToppCellwk_08-11-Mesenchymal|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

TSHZ3 NFIA NAP1L1 S1PR1

9.36e-0520053491416639e69621c5b36eebf061d81bccfe66f135
ToppCellTracheal-10x5prime-Immune_Myeloid-Mast_cell-Mast_cell|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

POTEE ADAMTS7 CASQ1 SAMSN1

9.36e-052005341c58860932ed47263a5a537a64f0343201463c21
ToppCellParenchymal-NucSeq-Immune_Lymphocytic-T-T_CD8-CD8_TRM|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SEMA4D NFATC2 PBX4 SAMSN1

9.36e-052005349ef322486e46e4ff05a8cbe06cf8019e996c94b3
ToppCellBiopsy_IPF-Immune-T_cells|Biopsy_IPF / Sample group, Lineage and Cell type

SEMA4D NFATC2 PBX4 SAMSN1

9.36e-05200534368c7334d211054f1e914a1be4027aa75e2df66c
DiseaseCarcinomatosis

FURIN RCN1 S1PR1 DNMT1

1.44e-04163484C0205699
DiseaseCarcinoma, Spindle-Cell

FURIN RCN1 S1PR1 DNMT1

1.44e-04163484C0205697
DiseaseUndifferentiated carcinoma

FURIN RCN1 S1PR1 DNMT1

1.44e-04163484C0205698
DiseaseAnaplastic carcinoma

FURIN RCN1 S1PR1 DNMT1

1.44e-04163484C0205696
DiseaseCarcinoma

FURIN RCN1 S1PR1 DNMT1

1.48e-04164484C0007097
Diseaseotosclerosis

SEMA4D PEAK1 DNMT1

3.15e-0481483EFO_0004213
Diseasehormone measurement, thyroid stimulating hormone measurement

NFIA PDE8B

1.02e-0329482EFO_0004730, EFO_0004748
Diseaseeicosapentaenoic acid measurement

TSHZ3 NFIA

1.17e-0331482EFO_0007760
DiseaseAnimal Mammary Neoplasms

FURIN RCN1 S1PR1

1.61e-03142483C0024667
DiseaseMammary Carcinoma, Animal

FURIN RCN1 S1PR1

1.61e-03142483C1257925

Protein segments in the cluster

PeptideGeneStartEntry
EFDPGQDTYQHPPKD

ACO2

536

Q99798
NSESEDGAYLDNPPK

CTAGE1

266

Q96RT6
DDPDLKYGQHPPDAV

DNMT1

361

P26358
HPQPEDPAKESYQDA

SAG

361

P10523
QEPKPYSDDDEINGV

CDC14C

381

A4D256
NFHEDLSYGPSEEPD

ADAMTS7

1071

Q9UKP4
QPSDADIKDQPENGH

NFIA

196

Q12857
GERPPEDNQSFQYDH

RCN1

46

Q15293
EENDPDYDPKKDQNP

NAP1L1

371

P55209
YEYLNPNEEEPNAHK

NFATC2

36

Q13469
LEHGTDPNIPDEYGN

POTEF

226

A5A3E0
NEVDPYHGNQEKVPE

MDN1

4861

Q9NU22
YHGNQEKVPEPEALD

MDN1

4866

Q9NU22
EDLEDKNNFGAEPPH

HSPH1

826

Q92598
SYNNNEDAPHEPDGV

DYNC1I1

306

O14576
DDHDQEEPDLKTGLY

HEXIM1

211

O94992
DGIERNHPDLAPNYD

PCSK6

206

P29122
EDDEGISHVPKPYGN

PEAK1

121

Q9H792
ELYSPQFGAKDDDPH

PDE8A

426

O60658
ELYSPQLGTKDEDPH

PDE8B

486

O95263
YLDEEGHQKDPDIGD

PI4KA

1696

P42356
KYHPDKNPDNPEAAD

DNAJC5

41

Q9H3Z4
RPEAPNEFYDGDHDN

HDAC3

406

O15379
LEHGTDPNIPDEYGN

POTEE

226

Q6S8J3
SHLNNPYPSEEAKEE

PBX4

231

Q9BYU1
PYNSEPAEESEHKNN

BRCA2

41

P51587
AENEEDEHSVNYKPP

ARHGDIA

16

P52565
IEKNHPDLAGNYDPG

FURIN

156

P09958
YHEPPEDDKASQRQF

CASQ1

71

P31415
PISDAKENPYGEDDN

INTS14

371

Q96SY0
PVDKDGNPDNETYLH

DDX19B

411

Q9UMR2
PEYRHLLDDNGQDKP

CAST

616

P20810
NEDNGAPENSVEKPH

LARP4

651

Q71RC2
EEKNEDHTPNYAPAN

EQTN

41

Q9NQ60
DNSSHPQKDEGDNPE

S1PR1

356

P21453
PEDENLYEKNPDSHG

NDUFB11

61

Q9NX14
FQASPEDHEKYGGDP

MRPL30

46

Q8TCC3
EDHEKYGGDPQNPHK

MRPL30

51

Q8TCC3
DHYAKDPDIEAPSNQ

SAMD7

221

Q7Z3H4
NHENLKGGDDLDPNY

CKM

111

P06732
ESDNHDPGQLDNSKP

SAMD9L

81

Q8IVG5
EDGENAHPYRNSDPV

SAMSN1

96

Q9NSI8
LEHGTDPNIPDEYGN

POTEI

226

P0CG38
HPKPALDTGYETEQD

SEMA4D

806

Q92854
LDEDESQAPYDPNGK

POLR2C

211

P19387
PLDVQKEFGYDSPHD

SLC7A6OS

291

Q96CW6
YVLSPEDDDDHQKDG

ZNF384

211

Q8TF68
PDGQYHLKPEEVDDF

REV1

626

Q9UBZ9
DKGLDPNFHDPDSGE

SHANK3

136

Q9BYB0
DPEEHTADGEPSAKY

TSHZ3

31

Q63HK5
QALYHDPDPSGKERA

TNPO3

16

Q9Y5L0
EKNNPHYDPSSKEDN

THYN1

141

Q9P016
SSYPDHKEGEDPNKA

ZNF622

351

Q969S3
LEHGTDPNIPDEYGN

POTEG

226

Q6S5H5
LEHGTDPNIPDEYGN

POTEM

226

A6NI47