Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	rRNA metabolic process	XRN1 NOP2 MAPT DICER1 YTHDF2 BMS1	1.86e-05	275	42	6	GO:0016072
GeneOntologyBiologicalProcess	spermatogonial cell division	DICER1 YTHDF2	4.03e-05	5	42	2	GO:0007284
GeneOntologyBiologicalProcess	regulation of axon extension	PLXNA4 SIN3A MAPT PTPRS	5.89e-05	104	42	4	GO:0030516
GeneOntologyBiologicalProcess	organelle assembly	PIKFYVE CENPC MAP4 NOP2 MAPT PTPRS DICER1 YTHDF2 DZIP1L CEP135	7.32e-05	1138	42	10	GO:0070925
GeneOntologyBiologicalProcess	regulation of neurogenesis	PLXNA4 FLT1 MAPT TF PTPRS DICER1 YTHDF2	7.34e-05	515	42	7	GO:0050767
GeneOntologyBiologicalProcess	central nervous system neuron differentiation	PLXNA4 SIN3A FAIM2 MAPT DICER1	7.63e-05	217	42	5	GO:0021953
GeneOntologyBiologicalProcess	regulation of extent of cell growth	PLXNA4 SIN3A MAPT PTPRS	1.10e-04	122	42	4	GO:0061387
GeneOntologyBiologicalProcess	regulation of hematopoietic progenitor cell differentiation	FLT1 YTHDF2 PUS7	1.12e-04	46	42	3	GO:1901532
GeneOntologyBiologicalProcess	axon extension	PLXNA4 SIN3A MAPT PTPRS	1.62e-04	135	42	4	GO:0048675
GeneOntologyBiologicalProcess	regulation of nervous system development	PLXNA4 FLT1 MAPT TF PTPRS DICER1 YTHDF2	2.43e-04	625	42	7	GO:0051960
GeneOntologyBiologicalProcess	regulation of response to biotic stimulus	IVL SIN3A RSAD2 PTPRS YTHDF2 FAM3A USP29	2.89e-04	643	42	7	GO:0002831
Domain	TAU_MAP_1	MAP4 MAPT	1.27e-05	3	39	2	PS00229
Domain	TAU_MAP_2	MAP4 MAPT	1.27e-05	3	39	2	PS51491
Domain	Tubulin-binding	MAP4 MAPT	1.27e-05	3	39	2	PF00418
Domain	MAP_tubulin-bd_rpt	MAP4 MAPT	1.27e-05	3	39	2	IPR001084
Domain	MAP2/MAP4/Tau	MAP4 MAPT	1.27e-05	3	39	2	IPR027324
Domain	PSI	PLXNA4 ITGB2	3.80e-03	44	39	2	IPR016201
Domain	PSI	PLXNA4 ITGB2	4.15e-03	46	39	2	SM00423
Pathway	BIOCARTA_EEA1_PATHWAY	EGF TF	7.45e-05	6	32	2	MM1577
Pathway	BIOCARTA_EEA1_PATHWAY	EGF TF	1.04e-04	7	32	2	M22064
Pathway	WP_NRP1TRIGGERED_SIGNALING_IN_PANCREATIC_CANCER	PLXNA4 FLT1 EGF	2.44e-04	54	32	3	M42568
Pubmed	Analysis of HIV-1 Gag protein interactions via biotin ligase tagging.	XRN1 MAP4 AHNAK HDLBP	5.56e-07	54	42	4	25631074
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	XRN1 ELOA SIN3A MAP4 NOP2 YTHDF2 AHNAK PUS7 HDLBP	1.41e-06	934	42	9	33916271
Pubmed	The gene for microtubule-associated protein 4 (Mtap4) maps to the distal region of mouse chromosome 9.	MAP4 TF	1.42e-06	2	42	2	8995766
Pubmed	An Alternative Phosphorylation Switch in Integrin β2 (CD18) Tail for Dok1 Binding.	DOK1 ITGB2	1.42e-06	2	42	2	26108885
Pubmed	Vascular endothelial growth factor receptor 1 signaling facilitates gastric ulcer healing and angiogenesis through the upregulation of epidermal growth factor expression on VEGFR1+CXCR4 + cells recruited from bone marrow.	FLT1 EGF	1.42e-06	2	42	2	23982810
Pubmed	Genetic ablation of Dicer in adult forebrain neurons results in abnormal tau hyperphosphorylation and neurodegeneration.	MAPT DICER1	1.42e-06	2	42	2	20660113
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	XRN1 MAP4 NOP2 MAPT DICER1 YTHDF2 AHNAK HDLBP	2.14e-06	724	42	8	36232890
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	XRN1 ELOA UBN1 CENPC NOP2 MYO10 DICER1 YTHDF2 HDLBP CEP135	3.05e-06	1327	42	10	32694731
Pubmed	The E3 ubiquitin ligase FBXL6 controls the quality of newly synthesized mitochondrial ribosomal proteins.	ELOA SIN3A NOP2 DICER1 YTHDF2 AHNAK HDLBP	3.84e-06	547	42	7	37267103
Pubmed	Effects of three microtubule-associated proteins (MAP2, MAP4, and Tau) on microtubules' physical properties and neurite morphology.	MAP4 MAPT	4.27e-06	3	42	2	37258650
Pubmed	MicroRNA-132 loss is associated with tau exon 10 inclusion in progressive supranuclear palsy.	MAPT DICER1	4.27e-06	3	42	2	21807765
Pubmed	Noncentrosomal microtubules and type II myosins potentiate epidermal cell adhesion and barrier formation.	MAP4 MAPT	4.27e-06	3	42	2	23091070
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	XRN1 MAP4 DICER1 AHNAK BMS1	4.49e-06	202	42	5	33005030
Pubmed	Global analysis of TDP-43 interacting proteins reveals strong association with RNA splicing and translation machinery.	XRN1 MAP4 NOP2 YTHDF2 AHNAK	7.27e-06	223	42	5	20020773
Pubmed	Leukotriene B4 type-1 receptor signaling promotes liver repair after hepatic ischemia/reperfusion injury through the enhancement of macrophage recruitment.	FLT1 EGF	8.53e-06	4	42	2	23629862
Pubmed	Phosphorylation of microtubule-associated proteins MAP2 and MAP4 by the protein kinase p110mark. Phosphorylation sites and regulation of microtubule dynamics.	MAP4 MAPT	8.53e-06	4	42	2	8631898
Pubmed	Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.	XRN1 ESS2 UBN1 CENPC NOP2 AHNAK CEP135	1.12e-05	645	42	7	25281560
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	XRN1 MAP4 NOP2 DICER1 AHNAK HDLBP BMS1	1.21e-05	653	42	7	22586326
Pubmed	HDLBP-stabilized lncFAL inhibits ferroptosis vulnerability by diminishing Trim69-dependent FSP1 degradation in hepatocellular carcinoma.	YTHDF2 HDLBP	1.42e-05	5	42	2	36423520
Pubmed	Identification of proximal SUMO-dependent interactors using SUMO-ID.	ESS2 UBN1 MAP4 YTHDF2 AHNAK HDLBP	1.49e-05	444	42	6	34795231
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	ELOA UBN1 CENPC MAP4 NOP2 YTHDF2 AHNAK HDLBP	1.61e-05	954	42	8	36373674
Pubmed	Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.	PIKFYVE DOK1 MAP4 PDE8B	2.04e-05	133	42	4	15144186
Pubmed	HDAC2 negatively regulates memory formation and synaptic plasticity.	SIN3A MAPT	2.13e-05	6	42	2	19424149
Pubmed	Matrix-screening reveals a vast potential for direct protein-protein interactions among RNA binding proteins.	ESS2 NOP2 MYO10 DICER1 YTHDF2 PUS7 BMS1	2.34e-05	723	42	7	34133714
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	XRN1 PIKFYVE ELOA ESS2 DICER1 YTHDF2 CEP135	2.55e-05	733	42	7	34672954
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	XRN1 UBN1 CENPC MAP4 NOP2 YTHDF2 AHNAK HDLBP BMS1	2.78e-05	1353	42	9	29467282
Pubmed	The p300/YY1/miR-500a-5p/HDAC2 signalling axis regulates cell proliferation in human colorectal cancer.	CDADC1 ELOA ESS2 MAP4 AHNAK	2.93e-05	298	42	5	30737378
Pubmed	Dicer is required for embryonic angiogenesis during mouse development.	FLT1 DICER1	2.98e-05	7	42	2	15613470
Pubmed	A novel dynamin-associating molecule, formin-binding protein 17, induces tubular membrane invaginations and participates in endocytosis.	EGF TF	2.98e-05	7	42	2	15252009
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	XRN1 ELOA SIN3A MAP4 NOP2 YTHDF2 BMS1	3.18e-05	759	42	7	35915203
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	ELOA SIN3A UBN1 MAP4 NOP2 MAPT HDLBP	3.60e-05	774	42	7	15302935
Pubmed	Perinatal lethality of microtubule-associated protein 1B-deficient mice expressing alternative isoforms of the protein at low levels.	MAP4 MAPT	3.97e-05	8	42	2	11085878
Pubmed	Protein Tyrosine Phosphatase δ Mediates the Sema3A-Induced Cortical Basal Dendritic Arborization through the Activation of Fyn Tyrosine Kinase.	PLXNA4 PTPRS	3.97e-05	8	42	2	28637841
Pubmed	LOXL2 Upregulates Phosphorylation of Ezrin to Promote Cytoskeletal Reorganization and Tumor Cell Invasion.	IVL MAP4 NOP2 TF AHNAK	4.56e-05	327	42	5	31409639
Pubmed	Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.	PIKFYVE DOK1 PALS2 DICER1 HDLBP	4.56e-05	327	42	5	15592455
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	XRN1 MAP4 NOP2 YTHDF2 PUS7 HDLBP BMS1	4.69e-05	807	42	7	22681889
Pubmed	Crucial role of fibroblasts in regulating epidermal morphogenesis.	IVL EGF	5.10e-05	9	42	2	12397374
Pubmed	MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis.	ELOA SIN3A ESS2 CENPC BMS1	5.40e-05	339	42	5	30415952
Pubmed	Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy.	MAPT BMS1	6.37e-05	10	42	2	21685912
Pubmed	HIV-1 inhibits autophagy in bystander macrophage/monocytic cells through Src-Akt and STAT3.	FLT1 ITGB2	7.78e-05	11	42	2	20661303
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	ELOA SIN3A ESS2 UBN1 CENPC NOP2	8.56e-05	608	42	6	36089195
Pubmed	Integrin beta cytoplasmic domain interactions with phosphotyrosine-binding domains: a structural prototype for diversity in integrin signaling.	DOK1 ITGB2	9.32e-05	12	42	2	12606711
Pubmed	The ubiquitin E3 ligase ARIH1 regulates hnRNP E1 protein stability, EMT and breast cancer progression.	MAP4 AHNAK HDLBP	1.00e-04	74	42	3	35102251
Pubmed	Proximity labeling of endogenous RICTOR identifies mTOR complex 2 regulation by ADP ribosylation factor ARF1.	MAP4 AHNAK PUS7 BMS1	1.32e-04	215	42	4	35973513
Pubmed	BioID Performed on Golgi Enriched Fractions Identify C10orf76 as a GBF1 Binding Protein Essential for Golgi Maintenance and Secretion.	XRN1 PIKFYVE AHNAK HDLBP	1.35e-04	216	42	4	31519766
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	XRN1 NOP2 TF PTPRS DICER1 PUS7 BMS1	1.52e-04	974	42	7	28675297
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	ELOA SIN3A ESS2 CENPC NOP2 AHNAK BMS1	1.67e-04	989	42	7	36424410
Pubmed	MARK4 is a novel microtubule-associated proteins/microtubule affinity-regulating kinase that binds to the cellular microtubule network and to centrosomes.	MAP4 MAPT	1.69e-04	16	42	2	14594945
Pubmed	Identification and developmental analysis of genes expressed by dopaminergic neurons of the substantia nigra pars compacta.	FAIM2 MYO10 DICER1	1.79e-04	90	42	3	15033168
Pubmed	Cross-Linking Mass Spectrometry Uncovers Interactions Between High-Density Lipoproteins and the SARS-CoV-2 Spike Glycoprotein.	ITGB2 TF AHNAK	1.91e-04	92	42	3	37343697
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	ELOA SIN3A UBN1 CENPC MAP4 AHNAK PUS7	1.94e-04	1014	42	7	32416067
Pubmed	Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.	IVL SIN3A MAP4 NOP2 AHNAK PUS7 HDLBP BMS1	2.00e-04	1367	42	8	32687490
Pubmed	RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease.	ELOA NOP2 MAPT YTHDF2 HDLBP BMS1	2.03e-04	713	42	6	29802200
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	ELOA MAP4 NOP2 DICER1 YTHDF2 AHNAK HDLBP BMS1	2.04e-04	1371	42	8	36244648
Pubmed	Study of FOXO1-interacting proteins using TurboID-based proximity labeling technology.	MAPT TF PDE8B AHNAK	2.11e-04	243	42	4	36964488
Pubmed	Mapping HSA 3 loci in cattle: additional support for the ancestral synteny of HSA 3 and 21.	ITGB2 TF	2.15e-04	18	42	2	1783381
Pubmed	Identification of proteins associated with ligand-activated estrogen receptor α in human breast cancer cell nuclei by tandem affinity purification and nano LC-MS/MS.	NOP2 TF YTHDF2 AHNAK	2.18e-04	245	42	4	21182205
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	ELOA CENPC PTPRS AHNAK HDLBP CEP135 BMS1	2.39e-04	1049	42	7	27880917
Pubmed	Hypoxia-inducible factor-1 deficiency results in dysregulated erythropoiesis signaling and iron homeostasis in mouse development.	FLT1 TF	2.40e-04	19	42	2	16787915
Pubmed	The PHLPP1 N-Terminal Extension Is a Mitotic Cdk1 Substrate and Controls an Interactome Switch.	XRN1 MAP4 AHNAK HDLBP	2.58e-04	256	42	4	33397691
Pubmed	Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	PIKFYVE FAIM2 DICER1	2.59e-04	102	42	3	10231032
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	XRN1 PLXNA4 ELOA TESMIN CENPC CCDC191 AHNAK DZIP1L	2.87e-04	1442	42	8	35575683
Pubmed	Genome-Wide CRISPR-Cas9 Screens Expose Genetic Vulnerabilities and Mechanisms of Temozolomide Sensitivity in Glioblastoma Stem Cells.	XRN1 YTHDF2 HDLBP	2.98e-04	107	42	3	30995489
Pubmed	UM171 Preserves Epigenetic Marks that Are Reduced in Ex Vivo Culture of Human HSCs via Potentiation of the CLR3-KBTBD4 Complex.	XRN1 MAPT AHNAK HDLBP	3.02e-04	267	42	4	33417871
Pubmed	Recruitment of the Mammalian Histone-modifying EMSY Complex to Target Genes Is Regulated by ZNF131.	XRN1 SIN3A AHNAK	3.23e-04	110	42	3	26841866
Pubmed	Assessment of Alzheimer's disease case-control associations using family-based methods.	MAPT TF	3.24e-04	22	42	2	18830724
Pubmed	Fibril treatment changes protein interactions of tau and α-synuclein in human neurons.	XRN1 MAP4 MAPT AHNAK HDLBP	3.24e-04	498	42	5	36634849
Pubmed	Klf14 is an imprinted transcription factor that regulates placental growth.	NELL1 FLT1	3.54e-04	23	42	2	31675530
Pubmed	Mapping a dynamic innate immunity protein interaction network regulating type I interferon production.	PALS2 NOP2 CCDC191 DICER1	3.77e-04	283	42	4	21903422
Pubmed	Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.	ELOA MAP4 NOP2 BMS1	3.77e-04	283	42	4	30585729
Pubmed	The MicroRNA miR-124 promotes neuronal differentiation by triggering brain-specific alternative pre-mRNA splicing.	MAP4 DICER1	4.20e-04	25	42	2	17679093
Pubmed	Intermediate phenotypes identify divergent pathways to Alzheimer's disease.	MAPT TF	4.20e-04	25	42	2	20574532
Pubmed	Conditionals by inversion provide a universal method for the generation of conditional alleles.	FLT1 DICER1	4.90e-04	27	42	2	23918385
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	XRN1 SIN3A MAP4 AHNAK HDLBP	5.06e-04	549	42	5	38280479
Pubmed	KSHV episome tethering sites on host chromosomes and regulation of latency-lytic switch by CHD4.	ELOA YTHDF2 AHNAK	5.27e-04	130	42	3	35545047
Pubmed	Inactivation of the Huntington's disease gene (Hdh) impairs anterior streak formation and early patterning of the mouse embryo.	FLT1 TF	5.28e-04	28	42	2	16109169
Pubmed	Post-transcriptional regulation of mouse neurogenesis by Pumilio proteins.	RAB31 DICER1	5.66e-04	29	42	2	28794184
Pubmed	The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells.	DOK1 MAPT ITGB2	5.75e-04	134	42	3	24658140
Pubmed	E-cadherin interactome complexity and robustness resolved by quantitative proteomics.	XRN1 IVL MAP4 AHNAK HDLBP	5.76e-04	565	42	5	25468996
Pubmed	Connecting the Dots in the Neuroglobin-Protein Interaction Network of an Unstressed and Ferroptotic Cell Death Neuroblastoma Model.	PLXNA4 MAP4 TF	5.88e-04	135	42	3	31405213
Pubmed	Large-scale concatenation cDNA sequencing.	DOK1 ELOA MAP4 DICER1 KCNK10	5.90e-04	568	42	5	9110174
Pubmed	In silico prediction of physical protein interactions and characterization of interactome orphans.	DOK1 MAPT ITGB2	6.00e-04	136	42	3	25402006
Pubmed	A "double adaptor" method for improved shotgun library construction.	DOK1 ELOA MAP4 DICER1 KCNK10	6.18e-04	574	42	5	8619474
Pubmed	Wnt1-cre-mediated conditional loss of Dicer results in malformation of the midbrain and cerebellum and failure of neural crest and dopaminergic differentiation in mice.	MAPT DICER1	6.47e-04	31	42	2	20457670
Pubmed	The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.	UBN1 NOP2 MYO10 AHNAK	6.86e-04	332	42	4	37433992
Pubmed	Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.	SIN3A MAP4 AHNAK HDLBP	6.86e-04	332	42	4	32786267
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	ELOA MAP4 NOP2 YTHDF2 AHNAK HDLBP BMS1	7.06e-04	1257	42	7	36526897
Pubmed	Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS.	NOP2 AHNAK CEP135 BMS1	7.49e-04	340	42	4	29478914
Pubmed	PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry.	XRN1 MAP4 YTHDF2 AHNAK	7.49e-04	340	42	4	24332808
Pubmed	HIV-1 Vpr induces cell cycle arrest and enhances viral gene expression by depleting CCDC137.	ELOA CENPC NOP2	7.68e-04	148	42	3	32538781
Pubmed	Sema6D acts downstream of bone morphogenetic protein signalling to promote atrioventricular cushion development in mice.	PLXNA4 FLT1	8.26e-04	35	42	2	28172500
Pubmed	Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways.	SIN3A MAP4 AHNAK	8.29e-04	152	42	3	16009940
Pubmed	The scaffold protein KSR1, a novel therapeutic target for the treatment of Merlin-deficient tumors.	PALS2 NOP2 YTHDF2 HDLBP	8.35e-04	350	42	4	26549023
Pubmed	BAG5 Promotes Alpha-Synuclein Oligomer Formation and Functionally Interacts With the Autophagy Adaptor Protein p62.	MAP4 AHNAK HDLBP	8.94e-04	156	42	3	32850835
Pubmed	Targeted ubiquitination and degradation of G-protein-coupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex.	SIN3A MAP4 BMS1	8.94e-04	156	42	3	22952844
Pubmed	DEAD-box helicase DDX27 regulates 3' end formation of ribosomal 47S RNA and stably associates with the PeBoW-complex.	ELOA NOP2	1.03e-03	39	42	2	25825154
Pubmed	In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators.	MAP4 NOP2 MYO10 YTHDF2 HDLBP BMS1	1.04e-03	971	42	6	33306668
Pubmed	Distinct nuclear and cytoplasmic assemblies and interactomes of the mammalian CTLH E3 ligase complex.	MAP4 NOP2 BMS1	1.09e-03	167	42	3	35833506
Pubmed	SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.	SIN3A MAP4 NOP2 DICER1 YTHDF2	1.12e-03	655	42	5	35819319
Pubmed	A genome-wide search for common SNP x SNP interactions on the risk of venous thrombosis.	PLXNA4 RSAD2	1.13e-03	41	42	2	23509962
Interaction	GTPBP1 interactions	XRN1 MAPT YTHDF2 HDLBP CEP135	4.50e-06	124	40	5	int:GTPBP1
Interaction	ZNF330 interactions	ELOA SIN3A ESS2 CENPC NOP2 PUS7 BMS1	2.46e-05	446	40	7	int:ZNF330
Interaction	LRRC31 interactions	XRN1 MAP4 DICER1 AHNAK BMS1	5.11e-05	205	40	5	int:LRRC31
Interaction	H3C1 interactions	PIKFYVE ELOA SIN3A UBN1 CENPC NOP2 MAPT AHNAK PUS7	5.36e-05	901	40	9	int:H3C1
Interaction	RHBDD1 interactions	XRN1 IVL MAP4 ITGB2 TF AHNAK	5.75e-05	346	40	6	int:RHBDD1
Interaction	TRIO interactions	PALS2 MAPT PTPRS MYO10	6.37e-05	109	40	4	int:TRIO
Interaction	CDC14A interactions	XRN1 NOP2 CEP135 BMS1	6.84e-05	111	40	4	int:CDC14A
Interaction	PTK2B interactions	DOK1 FLT1 MAPT ITGB2	8.96e-05	119	40	4	int:PTK2B
Interaction	NAA40 interactions	XRN1 ELOA SIN3A MAP4 NOP2 YTHDF2 AHNAK PUS7 HDLBP	1.01e-04	978	40	9	int:NAA40
Interaction	DKK2 interactions	IVL SIN3A TF	1.25e-04	49	40	3	int:DKK2
Interaction	PRKRA interactions	XRN1 CENPC NOP2 MAPT DICER1 BMS1	1.28e-04	400	40	6	int:PRKRA
Interaction	DHX40 interactions	ELOA ESS2 CENPC NOP2 BMS1	1.28e-04	249	40	5	int:DHX40
Interaction	FBXL6 interactions	ELOA SIN3A NOP2 DICER1 YTHDF2 AHNAK HDLBP	1.33e-04	583	40	7	int:FBXL6
Interaction	APEX1 interactions	ELOA SIN3A EGF CENPC NOP2 MAPT AHNAK PUS7 FAM3A BMS1	1.43e-04	1271	40	10	int:APEX1
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	UBN1 MAPT KCNK10	1.32e-03	181	22	3	694
GeneFamily	PDZ domain containing	PALS2 AHNAK	1.45e-02	152	22	2	1220
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	FLT1 PTPRS	1.62e-02	161	22	2	593
ToppCell	LPS_only-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PLXNA4 NELL1 PTPRS MYO10 KCNK10	8.22e-07	189	41	5	2a22b9fae70afb3dab8476f9c00e48a4df756410
ToppCell	droplet-Limb_Muscle-MUSCLE-30m\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	XRN1 FLT1 RSAD2 MYO10	2.14e-05	178	41	4	01dafd19de04eff459253eaa9a35debf8f3deedf
ToppCell	droplet-Liver-LIVER_HEP\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT1 MAP4 MAPT AHNAK	2.24e-05	180	41	4	423454e3390080ae03bb3cbb267255ebfe4df080
ToppCell	droplet-Liver-LIVER_HEP-30m\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT1 MAP4 MAPT AHNAK	2.24e-05	180	41	4	dd1b10c7f5a0fbc63163844ca1882884a24a84d3
ToppCell	COVID-19_Severe-Classical_Monocyte-cMono_1\|COVID-19_Severe / Disease condition and Cell class	ELOA CCDC191 ITGB2 AHNAK	2.28e-05	181	41	4	0d07a67e8ee3bca687b378afbc4044434e63556d
ToppCell	(7)_DC_plasmacytoid\|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)	PLXNA4 NELL1 PTPRS KCNK10	2.38e-05	183	41	4	2c6475c935b5a90931be6b3c53f1f707cfcd11f4
ToppCell	(0)_Myeloid-(011)_pDC\|(0)_Myeloid / immune cells in Peripheral Blood (logTPM normalization)	PLXNA4 NELL1 PTPRS KCNK10	2.65e-05	188	41	4	a81b5d840490d6a636fe168f8cff2c4984369f09
ToppCell	(011)_pDC\|World / immune cells in Peripheral Blood (logTPM normalization)	PLXNA4 NELL1 PTPRS KCNK10	2.82e-05	191	41	4	d82ac4f6d9863734e09bf3cb71c1354a49b66b4f
ToppCell	facs-Liver-Liver_non-hepato/SCs_st-18m-Endothelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT1 MAP4 MAPT MYO10	2.88e-05	192	41	4	6806a1a9fe00395dc1abc3e0124b4261dc701f31
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PLXNA4 NELL1 PTPRS KCNK10	3.00e-05	194	41	4	60622bd2f75bfe4c37f721cb12f03dab33f2f58d
ToppCell	COVID-19_Mild-Classical_Monocyte-cMono_3\|COVID-19_Mild / Disease condition and Cell class	ELOA RAB31 ITGB2 AHNAK	3.12e-05	196	41	4	f245e929a286cb097130572e1027b4f01be8b04d
ToppCell	COVID-19_Mild-Classical_Monocyte-cMono_3\|Classical_Monocyte / Disease condition and Cell class	ELOA RAB31 ITGB2 AHNAK	3.12e-05	196	41	4	15397ec27167bb2fb6fec120b68bf38fc71b2670
ToppCell	facs-Brain_Non-Myeloid\|facs / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT1 FAIM2 MAPT AHNAK	3.18e-05	197	41	4	a1f7eec1aca03432caa8fe817ff6d24b29d4062d
ToppCell	10x_5'_v1-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte-Z\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	FAIM2 MAPT TF PTPRS	3.31e-05	199	41	4	6fb5f931e6217142de38c1fffc011e63bda4772b
ToppCell	10x_5'_v1-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	FAIM2 MAPT TF PTPRS	3.31e-05	199	41	4	5d2e85e40b6b52b1809e680b952913d77215b3d0
ToppCell	10x_5'_v1-Non-neoplastic-Glial-Neuronal\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	FAIM2 MAPT TF PTPRS	3.31e-05	199	41	4	1bb5797e8e0552bf9b44bf4c958d1aa6dbe6c756
ToppCell	10x_5'_v1-Non-neoplastic-Glial-Neuronal-Oligodendrocyte\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	FAIM2 MAPT TF PTPRS	3.31e-05	199	41	4	9dd4b17fb8c70ab9e126b23b72600463f3db832d
ToppCell	mild\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	XRN1 RSAD2 CENPC AHNAK	3.37e-05	200	41	4	12f1685ce8f218433068e090c9d839cd5a1910bf
ToppCell	TCGA-Breast-Primary_Tumor-Breast_Carcinoma-Infiltrating_Ductal_and_Lobular_Carcinoma\|TCGA-Breast / Sample_Type by Project: Shred V9	RAB31 MAPT DICER1	1.57e-04	114	41	3	656072c25258d4c00f24f6ba17de6a5db891e7be
ToppCell	Severe-B_intermediate-1\|Severe / disease group and sub_cluster of B and Plasma cells(res = 0.5)	PIKFYVE CCDC191 AHNAK	2.12e-04	126	41	3	42a0bdbe18ef85146cac4e86b2b27d0b3b20d8a2
ToppCell	CTRL-Lymphoid-pDC\|CTRL / Disease state, Lineage and Cell class	PLXNA4 PTPRS KCNK10	2.82e-04	139	41	3	bbc10812b0c5b8c85e78171c12316becde8895c3
ToppCell	Control-B_intermediate-1\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	ELOA CCDC191 AHNAK	3.13e-04	144	41	3	984470ff6ddce4c743e2db78fa98dae055aaa273
ToppCell	Control-Plasmablast\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	NELL1 AHNAK HDLBP	3.19e-04	145	41	3	fe68582f5a15b9714cb84fa32ac880e13cb69895
ToppCell	tumor_Lymph_Node_/_Brain-Myeloid_cells-pDCs\|Myeloid_cells / Location, Cell class and cell subclass	PLXNA4 PTPRS KCNK10	3.96e-04	156	41	3	19472ef1642c2ad333aa3ce3675a25c6ab1d4556
ToppCell	PND07-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FLT1 ARMCX4 EGF	3.96e-04	156	41	3	1928c86deb3bcd01db4ae76919a351066aadb39a
ToppCell	severe_COVID-19-pDC\|World / disease group, cell group and cell class (v2)	PLXNA4 PTPRS KCNK10	4.18e-04	159	41	3	e1c48c4ceda116826819ff9adeed7bad6a58844d
ToppCell	severe_COVID-19-pDC\|severe_COVID-19 / disease group, cell group and cell class (v2)	PLXNA4 PTPRS KCNK10	4.18e-04	159	41	3	ea5088d27e42b8850455764d53b757ea8d8f14bc
ToppCell	COVID_non-vent-Lymphocytic-Dendritic-pDC\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	PLXNA4 PTPRS KCNK10	4.26e-04	160	41	3	61f4cb4eb4313d8318aadbb99595a6cb7fd919f7
ToppCell	COVID_non-vent-Lymphocytic-Dendritic\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	PLXNA4 PTPRS KCNK10	4.26e-04	160	41	3	34b4f710cfcb6ec370b8b074f3cbfe272f392cec
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PLXNA4 NELL1 EGF	4.26e-04	160	41	3	03b88dc7ad41c6ae443cab7e77ec666340bf432e
ToppCell	LAM-Lymphoid-pDC\|LAM / Condition, Lineage and Cell class	PLXNA4 PTPRS KCNK10	4.34e-04	161	41	3	bb5b44713e4da4406cdaa79dcf2aa9f97e3cf75a
ToppCell	droplet-Marrow-BM-30m-Myeloid-basophil\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RSAD2 TESMIN MYO10	4.42e-04	162	41	3	75df7ff779a3b9159ba97d852da1f8df650b9ce5
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Endothelial-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT1 RSAD2 MYO10	4.42e-04	162	41	3	465cb483f41023d6125ea147e16f404d8e8dc9bb
ToppCell	ILEUM-non-inflamed-(3)_pDC\|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	PLXNA4 PTPRS KCNK10	4.50e-04	163	41	3	bc5411702badab39143905aa51676b4bbfad2041
ToppCell	saliva-Severe-critical_progression_d12-22_with-steroid-Myeloid-Macrophage-macrophage,_alveolar-Macro_c2-CCL3L1\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	RSAD2 PALS2 PTPRS	4.50e-04	163	41	3	130c84bca3f72ab7d1a4fee2990c3d01600318ed
ToppCell	Influenza_Severe-pDC\|World / Disease group and Cell class	PLXNA4 PTPRS KCNK10	4.74e-04	166	41	3	bd25ce4c03c3d6cd9d986b9be1d355da52f0f2d7
ToppCell	Influenza_Severe-pDC\|Influenza_Severe / Disease group and Cell class	PLXNA4 PTPRS KCNK10	4.74e-04	166	41	3	b43a5cd4d28118cf6e56a435deb8ea9435608a90
ToppCell	Control-B_intermediate-1\|Control / disease group and sub_cluster of B and Plasma cells(res = 0.5)	ELOA CCDC191 AHNAK	4.83e-04	167	41	3	948504367ecf58144d9dd74d2ec531358fc4b309
ToppCell	10x5'-Lung-Myeloid_Dendritic-pDC\|Lung / Manually curated celltypes from each tissue	PLXNA4 PTPRS KCNK10	4.91e-04	168	41	3	90f713dae3fcbd6ca801a019e3861c263ff3366b
ToppCell	B_cells-pDCs\|World / Immune cells in Kidney/Urine in Lupus Nephritis	PLXNA4 PTPRS KCNK10	4.91e-04	168	41	3	dc8f94424f60ab56facdcffa969e7f3466ee1b6e
ToppCell	facs-Heart-RV-24m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT1 RSAD2 MYO10	4.91e-04	168	41	3	831b000e26b4a7e7fdfa3988372e0281c45eadbb
ToppCell	(3)_DC_plasmacytoid\|World / Lung cell shreds - cell class (v4) and cell subclass (v4)	PLXNA4 PTPRS KCNK10	4.91e-04	168	41	3	8a913db9b2a1a4ff96fb139734a3834e6aa263f1
ToppCell	(3)_MNP-(3)_DC_plasmacytoid\|(3)_MNP / Lung cell shreds - cell class (v4) and cell subclass (v4)	PLXNA4 PTPRS KCNK10	4.91e-04	168	41	3	13c160ea1a19b47d2e7e2dae818c8dcde4e3e377
ToppCell	3'-Parenchyma_lung-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell-Plasmacytoid_DCs-Plasmacytoid_DCs_L.1.5.1.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PLXNA4 PTPRS KCNK10	4.91e-04	168	41	3	59b698f58cb206f0f8f0e8ad72b445d14ba24728
ToppCell	facs-Kidney\|facs / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT1 RSAD2 EGF	4.91e-04	168	41	3	d2f17a470e04f8f0edb111894027bcfc6ee1a12f
ToppCell	343B-Myeloid-Dendritic-pDC\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	PLXNA4 PALS2 PTPRS	5.00e-04	169	41	3	632aa3ab39ec87bafcefec6cddf71129a054d3b0
ToppCell	tumor_Lymph_Node_/_Brain-T/NK_cells-Exhausted_Tfh\|T/NK_cells / Location, Cell class and cell subclass	FAIM2 PDE8B PUS7	5.00e-04	169	41	3	625788d86f0ceebcf2653a251db1f1a9f9746d29
ToppCell	Healthy_Control-Lymphoid-pDC\|Healthy_Control / Condition, Lineage, Cell class and cell subclass	PLXNA4 PALS2 PTPRS	5.00e-04	169	41	3	a4e9b8b2f0338203455ba941b8f99bf4884d26f0
ToppCell	Healthy_Control-Lymphoid-pDC-\|Healthy_Control / Condition, Lineage, Cell class and cell subclass	PLXNA4 PALS2 PTPRS	5.00e-04	169	41	3	338ce99897cb522b86edd603f75bc15ec4dfcda3
ToppCell	PND07-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP2-CAP2_prolif\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MAPT PDE8B CEP135	5.00e-04	169	41	3	8a6d05b5d60b2b2e43a8ff7521feb79cd6dbd940
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell-Plasmacytoid_DCs\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PLXNA4 PTPRS KCNK10	5.08e-04	170	41	3	92e765ae0d3adb38d3b22fddb873fd5ccad3fd44
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PLXNA4 PTPRS KCNK10	5.08e-04	170	41	3	9f8b215caa1afa3cd7104c06fca7cfd790640f66
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell-Plasmacytoid_DCs-Plasmacytoid_DCs_L.1.5.1.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PLXNA4 PTPRS KCNK10	5.08e-04	170	41	3	b49f7c8a27078de2137ed04f74cfee30729cfa5e
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell-Plasmacytoid_DCs-Plasmacytoid_DCs_L.1.5.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PLXNA4 PTPRS KCNK10	5.17e-04	171	41	3	4fd2c7977c512c51507f055fc74b111c0228ed8b
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic-Plasmacytoid_Dendritic_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PLXNA4 PTPRS KCNK10	5.17e-04	171	41	3	39c8ae139e449217091e1481eb5e2aafb8f69a1c
ToppCell	ICU-SEP-Myeloid-pDC\|ICU-SEP / Disease, Lineage and Cell Type	PLXNA4 PTPRS KCNK10	5.17e-04	171	41	3	72c448a0dc4c569bd6b465f9aa395f38034e7ea6
ToppCell	metastatic_Lymph_Node-Myeloid_cells-pDCs\|metastatic_Lymph_Node / Location, Cell class and cell subclass	PLXNA4 PTPRS KCNK10	5.17e-04	171	41	3	1f8e66073088fc1969782e443bf00f8c1877ea91
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-CD4/CD8-CD4_INF-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	XRN1 RSAD2 AHNAK	5.17e-04	171	41	3	e6dfbd2652b67577c8834c05348f62150637f348
ToppCell	COVID_vent-Lymphocytic-Dendritic-pDC\|COVID_vent / Disease condition, Lineage, Cell class and subclass	PLXNA4 PTPRS KCNK10	5.17e-04	171	41	3	779c951d274ecbd1d546ac425d6c8e718623be5a
ToppCell	COVID_vent-Lymphocytic-Dendritic\|COVID_vent / Disease condition, Lineage, Cell class and subclass	PLXNA4 PTPRS KCNK10	5.17e-04	171	41	3	debbb071d260639b16269c94d172766908325c58
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic-Plasmacytoid_Dendritic_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PLXNA4 PTPRS KCNK10	5.17e-04	171	41	3	af1c93eb75f45c042ea475d93db56e4da207e31f
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-CD4/CD8-CD4_INF\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	XRN1 RSAD2 AHNAK	5.17e-04	171	41	3	ddaeb96ce9c9c3bf232b4a42266fa2ee7e8f3f41
ToppCell	COVID-pDC\|COVID / Condition, Cell_class and T cell subcluster	PLXNA4 PTPRS KCNK10	5.26e-04	172	41	3	3ecbb000495dde32f6153ef6bdea9c8802ff3985
ToppCell	mild_COVID-19-pDC\|World / disease group, cell group and cell class (v2)	PLXNA4 PTPRS KCNK10	5.26e-04	172	41	3	dab2f1a05c7df58d9387b13271b3f1f1583f9ac3
ToppCell	COVID-pDC-\|COVID / Condition, Cell_class and T cell subcluster	PLXNA4 PTPRS KCNK10	5.26e-04	172	41	3	a7827faa1afab51fdaf0cb1a2babcd2e00d411e5
ToppCell	5'-Adult-Distal_Rectal-Hematopoietic\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RAB31 ITGB2 HDLBP	5.35e-04	173	41	3	b335ca2a247156eba821943b2b9fc9922230b409
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell-Degenerative_Ascending_Thin_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PLXNA4 PALS2 ITGB2	5.44e-04	174	41	3	46bd0ef7d0541386de7a901d85d53d0176dc92bf
ToppCell	CTRL-Lymphoid-pDC\|Lymphoid / Disease state, Lineage and Cell class	PLXNA4 PTPRS KCNK10	5.44e-04	174	41	3	ff4315e9fad198cc323fc987deb8652da137cf98
ToppCell	facs-Heart-LV-24m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MAPT PDE8B DZIP1L	5.44e-04	174	41	3	7cd6f9103133f8d7b90f9ff4b3b0b078cf554542
ToppCell	COPD-Myeloid-pDC\|World / Disease state, Lineage and Cell class	PLXNA4 PTPRS KCNK10	5.44e-04	174	41	3	be8227398300711ccda5ecc41ad34064bb246b19
ToppCell	facs-Heart-LV-24m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MAPT PDE8B DZIP1L	5.44e-04	174	41	3	a0a059bb2a64d7011e206db2ebcdf3eb655a925a
ToppCell	severe_influenza-pDC\|severe_influenza / disease group, cell group and cell class (v2)	PLXNA4 PTPRS KCNK10	5.44e-04	174	41	3	d8d2ded5812ed3b3db4109585714a6513c13326a
ToppCell	IIF-Myeloid-pDC\|IIF / Disease, Lineage and Cell Type	PLXNA4 PTPRS KCNK10	5.53e-04	175	41	3	35cfb7d0b88678ff5b83ad6e19dbc15a908a3fcc
ToppCell	mild_COVID-19-pDC\|mild_COVID-19 / disease group, cell group and cell class (v2)	PLXNA4 PTPRS KCNK10	5.53e-04	175	41	3	b87f279a7519710146c49d6acccb0adedc195965
ToppCell	Adult-Epithelial-lung_neuroendocrine_cell_(PNEC)\|Adult / Lineage, Cell type, age group and donor	NELL1 TESMIN KCNK10	5.53e-04	175	41	3	4db1a3c284488b3f6de7568363f176d74e2a4587
ToppCell	nucseq-Immune-Immune_Myeloid-Myeloid_Dendritic-pDC\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	PLXNA4 PTPRS KCNK10	5.53e-04	175	41	3	37c2d4e0b6e9a3171931797ce9a54f3347288e57
ToppCell	IPF-Myeloid-pDC\|World / Disease state, Lineage and Cell class	PLXNA4 PTPRS KCNK10	5.53e-04	175	41	3	a06785a4ded01adfd29ca4c20f7759eccbe274cb
ToppCell	normal_Lymph_Node-B_lymphocytes-GrB-secreting_B_cells\|normal_Lymph_Node / Location, Cell class and cell subclass	PLXNA4 PTPRS KCNK10	5.53e-04	175	41	3	29fbdfe1d3bfcb063be2bced0128a33176c5b78f
ToppCell	Adult-Epithelial-lung_neuroendocrine_cell_(PNEC)-D231\|Adult / Lineage, Cell type, age group and donor	NELL1 TESMIN KCNK10	5.53e-04	175	41	3	8d9f44a2633b71fb4d2b4a7d9530f954e07c4a18
ToppCell	TCGA-Cervix-Primary_Tumor-Cervical_Carcinoma-Non-keratinizing_Cervical_Squamous_Cell_Carcinoma-3\|TCGA-Cervix / Sample_Type by Project: Shred V9	XRN1 IVL CENPC	5.53e-04	175	41	3	0cc215109d9915af47e4d0a120ce2e46910715fa
ToppCell	mild-Myeloid-pDC\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	PLXNA4 PTPRS KCNK10	5.62e-04	176	41	3	59a9c262c252b7d220a025837922d98e9d6b0a24
ToppCell	Monocytes-IFN-activated_Monocytes\|Monocytes / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	FLT1 RSAD2 PALS2	5.62e-04	176	41	3	6a4b403ee3e4dc4f23fbd7a154011e41fd429a9e
ToppCell	B_cells-pDCs\|B_cells / Immune cells in Kidney/Urine in Lupus Nephritis	PLXNA4 PTPRS KCNK10	5.62e-04	176	41	3	ce757de9e09a225f3f96433f103f43619b0e0dda
ToppCell	T_cells-Tph_and_Tfh\|T_cells / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	FLT1 FAIM2 MAPT	5.62e-04	176	41	3	56c055488e34605d32562571a2fee621b47c9441
ToppCell	normal_Lymph_Node-B_lymphocytes-GrB-secreting_B_cells\|B_lymphocytes / Location, Cell class and cell subclass	PLXNA4 PTPRS KCNK10	5.62e-04	176	41	3	d6e660df92a3d7dd5732171ee623763faf108476
ToppCell	droplet-Heart-nan-3m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	XRN1 AHNAK HDLBP	5.62e-04	176	41	3	749b47eac5436fa34e0d243ffbc6f1897f4e431e
ToppCell	facs-Heart-LV\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT1 RSAD2 MYO10	5.62e-04	176	41	3	483e36d9bb7268bf179e69a65e1a0be099035162
ToppCell	10x5'-GI_large-bowel-Lymphocytic_T_CD4-Tnaive/CM_CD4\|GI_large-bowel / Manually curated celltypes from each tissue	ARMCX4 TESMIN CEP135	5.72e-04	177	41	3	eb87ea93e36a8f97442ec8515f658ee61932dc0f
ToppCell	droplet-Limb_Muscle-MUSCLE-30m-Endothelial\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT1 RSAD2 MYO10	5.72e-04	177	41	3	ca5a30b3e7bcfdd8de01ceaf7449735b5cd503af
ToppCell	droplet-Limb_Muscle-MUSCLE-30m-Endothelial-nan\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT1 RSAD2 MYO10	5.72e-04	177	41	3	f471f7747d6e8db7546899019af9508f48a14f89
ToppCell	Control-Myeloid-pDC\|Control / Disease state, Lineage and Cell class	PLXNA4 PTPRS KCNK10	5.72e-04	177	41	3	3940663bb5b45b2ca9f772550380a516c53e410b
ToppCell	droplet-Limb_Muscle-MUSCLE-30m-Endothelial-endothelial_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT1 RSAD2 MYO10	5.72e-04	177	41	3	cd0684b876c2a7d5fe7e2773e8e25bb61ecbc795
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PLXNA4 PTPRS KCNK10	5.72e-04	177	41	3	507f06d31ab773099c9431b6f433899dc97b5566
ToppCell	RV-11._Adipocyte\|World / Chamber and Cluster_Paper	PLXNA4 PTPRS PDE8B	5.72e-04	177	41	3	f0edf04930692418953e4f00a917257804ec0ffd
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell-Plasmacytoid_DCs\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PLXNA4 PTPRS KCNK10	5.72e-04	177	41	3	8887ff6341eb070bdaa890cc2cd7745f0cf1b0af
ToppCell	Control-Myeloid-pDC\|Myeloid / Disease state, Lineage and Cell class	PLXNA4 PTPRS KCNK10	5.72e-04	177	41	3	e82115bfc32c7b689460fbc5caeb983c1aabe30f
ToppCell	COVID-19_Moderate-B_intermediate\|COVID-19_Moderate / disease group, cell group and cell class	PIKFYVE FLT1 PALS2	5.72e-04	177	41	3	68e3d12a0c048a2d0f1b9680c7338a35855bba30
ToppCell	COPD-Myeloid-pDC\|COPD / Disease state, Lineage and Cell class	PLXNA4 PTPRS KCNK10	5.72e-04	177	41	3	415aa023195a7f961c09529f65cdcc7bb90eaf5d
ToppCell	myeloid-Dendritic_cell-Plasmacytoid_dendritic_cell\|myeloid / Lineage, cell class and subclass	PLXNA4 PTPRS KCNK10	5.81e-04	178	41	3	f75591988bbbeba073b66329a3437cb9b02f7648
ToppCell	Severe-B_intermediate-10\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	PIKFYVE PALS2 ITGB2	5.81e-04	178	41	3	b7374a97c51239782bed658381a02cb1b3d9bf66
Drug	ZD4190	NELL1 FLT1 EGF	6.05e-06	20	41	3	CID005329032
Drug	sulfo-SANPAH	EGF TF	9.48e-06	3	41	2	CID003035866
Drug	Ferric phosphate dihydrate	FLT1 TF	9.48e-06	3	41	2	CID011615510
Drug	Captopril [62571-86-2]; Down 200; 17.2uM; PC3; HT_HG-U133A	ELOA UBN1 MAP4 MYO10 DICER1	1.69e-05	179	41	5	4585_DN
Drug	Pempidine tartrate [546-48-5]; Down 200; 13uM; PC3; HT_HG-U133A	ELOA UBN1 MAP4 MYO10 DICER1	2.25e-05	190	41	5	4307_DN
Drug	Tropicamide [1508-75-4]; Down 200; 14uM; PC3; HT_HG-U133A	FLT1 RAB31 MYO10 DICER1 CEP135	2.43e-05	193	41	5	4280_DN
Drug	Benfotiamine [22457-89-2]; Down 200; 8.6uM; PC3; HT_HG-U133A	ELOA UBN1 MAP4 MYO10 DICER1	2.49e-05	194	41	5	4312_DN
Drug	17-DMAG; Down 200; 0.1uM; MCF7; HT_HG-U133A	DOK1 NOP2 MAPT PTPRS PDE8B	2.55e-05	195	41	5	5573_DN
Drug	Verapamyl hydrochloride [152-11-4]; Up 200; 8.2uM; PC3; HT_HG-U133A	RAB31 MAPT PDE8B AHNAK HDLBP	2.81e-05	199	41	5	6287_UP
Drug	Propylthiouracil [51-52-5]; Up 200; 23.4uM; HL60; HT_HG-U133A	IVL FLT1 MAP4 MAPT USP29	2.81e-05	199	41	5	2476_UP
Drug	Nsc102809	EGF TF	3.15e-05	5	41	2	CID005458192
Disease	tauopathy (implicated_via_orthology)	MAP4 MAPT	7.61e-05	10	39	2	DOID:680 (implicated_via_orthology)
Disease	placenta growth factor measurement	NELL1 FLT1	9.29e-05	11	39	2	EFO_0010626
Disease	IGFBP-1 measurement	NELL1 MYO10	1.32e-04	13	39	2	EFO_0005118
Disease	waist-hip ratio	XRN1 CDADC1 NELL1 UBN1 MAPT PTPRS PDE8B AHNAK	1.69e-04	1226	39	8	EFO_0004343
Disease	Dermatitis	EGF ITGB2	2.02e-04	16	39	2	C0011603
Disease	serum hepcidin measurement	NELL1 TF	2.57e-04	18	39	2	EFO_0004504
Disease	DiGeorge syndrome (implicated_via_orthology)	ESS2 DICER1	2.87e-04	19	39	2	DOID:11198 (implicated_via_orthology)
Disease	Weight Gain	MAP4 MAPT MYO10	3.35e-04	102	39	3	C0043094
Disease	cancer (implicated_via_orthology)	FLT1 SIN3A NOP2 ITGB2	4.26e-04	268	39	4	DOID:162 (implicated_via_orthology)
Disease	bone fracture	PLXNA4 RAB31 AHNAK	4.40e-04	112	39	3	EFO_0003931
Disease	Dwarfism	SIN3A PUS7	5.01e-04	25	39	2	C0013336
Disease	progressive supranuclear palsy	MAPT BMS1	7.73e-04	31	39	2	MONDO_0019037
Disease	Chloracne	ITGB2 AHNAK	8.76e-04	33	39	2	C0263454
Disease	Degenerative Diseases, Central Nervous System	MAPT PDE8B	1.22e-03	39	39	2	C0270715
Disease	Degenerative Diseases, Spinal Cord	MAPT PDE8B	1.22e-03	39	39	2	C0751733
Disease	Neurodegenerative Disorders	MAPT PDE8B	1.22e-03	39	39	2	C0524851
Disease	cardiac troponin I measurement	NELL1 MAPT MYO10	1.63e-03	176	39	3	EFO_0010071
Disease	Parkinson's disease symptom measurement	XRN1 PLXNA4	1.85e-03	48	39	2	EFO_0600011

Protein segments in the cluster

Peptide	Gene	Start	Entry
HVNAKGPQVSGELKG	AHNAK	5421	Q09666
QKSQKNEEGKHGPLG	CDADC1	56	Q9BWV3
GHGIGKNQPRNKQME	DICER1	481	Q9UPY3
VHKGKSGPNTQNEDI	BMS1	791	Q14692
NKVKGNPHTVLKVGA	ARMCX4	606	Q5H9R4
PHENGNNGTIKVEKP	RAB31	171	Q13636
GVAEGGKQKKQEQPV	DZIP1L	191	Q8IYY4
KAPGTEGQQQVHGEK	FAIM2	11	Q9BWQ8
EGQQQVHGEKKEAPA	FAIM2	16	Q9BWQ8
KDNIKHVPGGGNVQI	MAP4	1011	P27816
HVPGGGNVQIQNKKV	MAP4	1016	P27816
DLIQNPQIRAKHGGK	PLXNA4	1066	Q9HCM2
QQHVKITPVIGQGGK	PDE8B	356	O95263
IKQTNKVPHPGSVGN	MYO10	1611	Q9HD67
NNLRLKGPEQLNKHG	KCNK10	421	P57789
KGPEQLNKHGQGASE	KCNK10	426	P57789
GQRNQKHGLFKGIIQ	NELL1	191	Q92832
GQVHKTKEQFGQDGP	PTPRS	1861	Q13332
VGAKGVQNKSPFEQH	FAM3A	186	P98173
HNGGQKQLSPQKVTL	ITGB2	91	P05107
KEVNGHEVGNNPKEL	PALS2	176	Q9NZW5
QEKNLHAVVQTPGGK	CEP135	146	Q66GS9
GGDTQKKQLINPHVE	PIKFYVE	1796	Q9Y2I7
LNAQHKQGKVGPDGK	ESS2	271	Q96DF8
RQKAQGKAGQGHDVL	DOK1	251	Q99704
LGEPHGKGVVSQNKE	ELOA	256	Q14241
IKEHQDLKNGGQPVA	EGF	1101	P01133
PQEEKGKQHVGQDIL	CENPC	876	Q03188
GNKQHKTLGAEPSQQ	CCDC191	516	Q8NCU4
KGQLGNVKPQHNKGC	TESMIN	356	Q9Y4I5
IGRGQGKKNHVENLQ	RSAD2	191	Q8WXG1
QKNPLKLGELQGNHF	PUS7	331	Q96PZ0
RNDHGGTVKKPQLNN	SIN3A	401	Q96ST3
GQLKHLEQQEGQPKH	IVL	311	P07476
HQPLGRAKGVEKQQL	NOP2	746	P46087
FVKHQTVPQNTGGKN	TF	551	P02787
VHGEKINKGQPAPDN	SAGE2P	261	A6NJ88
GGVHNQFIPLQVTKK	XRN1	1596	Q8IZH2
HVKKGILENQGGKGQ	USP29	156	Q9HBJ7
ENLKHQPGGGKVQII	MAPT	581	P10636
GPQVKVFHAGTQQQK	UBN1	801	Q9NPG3
QFHKNIIGKGGANIK	HDLBP	591	Q00341
HPEGKIGNQVEKAIN	ZNF701	221	Q9NV72
KNNHKIQQEPGIILG	FLT1	696	P17948
PKGQGNKVQNGSVHQ	YTHDF2	11	Q9Y5A9