Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	phosphotransferase activity, alcohol group as acceptor	PIKFYVE MST1 STK36 CERK TKFC GALK2 GRK2 GRK3 PGM2L1 PKN1 PKN2 LTBP1 MST1L CIT NEK9	2.40e-09	709	61	15	GO:0016773
GeneOntologyMolecularFunction	kinase activity	PIKFYVE MST1 STK36 CERK TKFC GALK2 GRK2 GRK3 PGM2L1 PKN1 PKN2 LTBP1 MST1L CIT NEK9	6.58e-09	764	61	15	GO:0016301
GeneOntologyMolecularFunction	transferase activity, transferring phosphorus-containing groups	PIKFYVE MST1 STK36 CERK TKFC GALK2 GRK2 GRK3 PGM2L1 PKN1 PKN2 LTBP1 MST1L POLQ CIT NEK9	1.37e-08	938	61	16	GO:0016772
GeneOntologyMolecularFunction	protein kinase activity	PIKFYVE MST1 STK36 GRK2 GRK3 PKN1 PKN2 LTBP1 MST1L CIT NEK9	1.76e-06	600	61	11	GO:0004672
GeneOntologyMolecularFunction	protein serine/threonine kinase activity	PIKFYVE STK36 GRK2 GRK3 PKN1 PKN2 LTBP1 CIT NEK9	7.91e-06	446	61	9	GO:0004674
GeneOntologyMolecularFunction	serine-type endopeptidase activity	MST1 LPA MST1L LTF PLG CTSS	2.47e-05	190	61	6	GO:0004252
GeneOntologyMolecularFunction	serine-type peptidase activity	MST1 LPA MST1L LTF PLG CTSS	3.99e-05	207	61	6	GO:0008236
GeneOntologyMolecularFunction	serine hydrolase activity	MST1 LPA MST1L LTF PLG CTSS	4.55e-05	212	61	6	GO:0017171
GeneOntologyMolecularFunction	beta-adrenergic receptor kinase activity	GRK2 GRK3	5.49e-05	4	61	2	GO:0047696
GeneOntologyMolecularFunction	histone kinase activity	MST1 PKN1 MST1L	8.42e-05	28	61	3	GO:0035173
GeneOntologyMolecularFunction	peptidase activity	MST1 SCRN3 LPA USP24 MST1L LTF PLG SPRTN CTSS	1.55e-04	654	61	9	GO:0008233
GeneOntologyMolecularFunction	G protein-coupled receptor kinase activity	GRK2 GRK3	1.91e-04	7	61	2	GO:0004703
GeneOntologyMolecularFunction	endopeptidase activity	MST1 LPA MST1L LTF PLG SPRTN CTSS	3.27e-04	430	61	7	GO:0004175
GeneOntologyMolecularFunction	intramolecular phosphotransferase activity	PGM2L1 PGM5	4.96e-04	11	61	2	GO:0016868
GeneOntologyMolecularFunction	transcription coactivator binding	RORC RELA CIT	6.02e-04	54	61	3	GO:0001223
GeneOntologyMolecularFunction	protein serine kinase activity	PIKFYVE STK36 PKN1 PKN2 CIT NEK9	8.28e-04	363	61	6	GO:0106310
GeneOntologyMolecularFunction	transcription coregulator binding	STK36 RORC RELA CIT	8.86e-04	140	61	4	GO:0001221
GeneOntologyMolecularFunction	protein antigen binding	LPA PLG	1.07e-03	16	61	2	GO:1990405
GeneOntologyMolecularFunction	diacylglycerol-dependent serine/threonine kinase activity	PKN1 PKN2	1.07e-03	16	61	2	GO:0004697
GeneOntologyMolecularFunction	apolipoprotein binding	LPA PLG	1.68e-03	20	61	2	GO:0034185
GeneOntologyMolecularFunction	kinase binding	MST1 LPA PKN1 RELA MST1L PLG CIT NEK9 RHOF	2.57e-03	969	61	9	GO:0019900
GeneOntologyMolecularFunction	intramolecular transferase activity	PGM2L1 PGM5	3.53e-03	29	61	2	GO:0016866
GeneOntologyMolecularFunction	fibronectin binding	LPA CTSS	6.01e-03	38	61	2	GO:0001968
GeneOntologyBiologicalProcess	extracellular matrix disassembly	MELTF LPA PLG CTSS	7.67e-05	75	62	4	GO:0022617
GeneOntologyBiologicalProcess	positive regulation of fibrinolysis	LPA PLG	8.84e-05	5	62	2	GO:0051919
GeneOntologyBiologicalProcess	desensitization of G protein-coupled receptor signaling pathway	GRK2 GRK3 PTGER3	1.09e-04	31	62	3	GO:0002029
GeneOntologyBiologicalProcess	negative adaptation of signaling pathway	GRK2 GRK3 PTGER3	1.21e-04	32	62	3	GO:0022401
GeneOntologyBiologicalProcess	adaptation of signaling pathway	GRK2 GRK3 PTGER3	1.21e-04	32	62	3	GO:0023058
GeneOntologyBiologicalProcess	trans-synaptic signaling by BDNF, modulating synaptic transmission	LPA PLG	1.85e-04	7	62	2	GO:0099183
GeneOntologyBiologicalProcess	aldehyde metabolic process	TKFC TKT RELA HAGH	1.92e-04	95	62	4	GO:0006081
GeneOntologyBiologicalProcess	hexose metabolic process	MST1 TKFC GALK2 GPT PGM2L1 RORC	2.08e-04	284	62	6	GO:0019318
GeneOntologyCellularComponent	junctional membrane complex	JPH1 JPH4	2.78e-04	9	59	2	GO:0030314
GeneOntologyCellularComponent	junctional sarcoplasmic reticulum membrane	JPH1 JPH4	3.47e-04	10	59	2	GO:0014701
MousePheno	abnormal mammary gland connective tissue morphology	LPA PLG	1.41e-05	2	53	2	MP:0009507
MousePheno	esophageal ulcer	LPA PLG	1.41e-05	2	53	2	MP:0004547
MousePheno	duodenal ulcer	LPA PLG	1.41e-05	2	53	2	MP:0003273
MousePheno	perianal ulcer	LPA PLG	1.41e-05	2	53	2	MP:0005035
MousePheno	ectropion	LPA PLG	1.41e-05	2	53	2	MP:0006164
MousePheno	colitis	MST1 RAG2 LPA RORC MST1L PLG	2.91e-05	159	53	6	MP:0002816
MousePheno	absent cornea epithelium	LPA PLG	4.22e-05	3	53	2	MP:0020856
MousePheno	large intestinal inflammation	MST1 RAG2 LPA RORC MST1L PLG	4.82e-05	174	53	6	MP:0003304
MousePheno	increased circulating fibrinogen level	LPA PLG	8.42e-05	4	53	2	MP:0012331
MousePheno	proctitis	LPA PLG	8.42e-05	4	53	2	MP:0003305
MousePheno	intestinal inflammation	MST1 RAG2 LPA RORC MST1L PLG	9.08e-05	195	53	6	MP:0001858
MousePheno	liver fibrosis	LPA RELA LTBP1 PLG	2.03e-04	77	53	4	MP:0003333
MousePheno	gastric ulcer	LPA PLG	2.10e-04	6	53	2	MP:0003282
MousePheno	small inguinal lymph nodes	RAG2 RORC	2.10e-04	6	53	2	MP:0009624
MousePheno	increased acute phase protein level	LPA PLG	2.93e-04	7	53	2	MP:0014499
MousePheno	abnormal conjunctival epithelium morphology	LPA PLG	2.93e-04	7	53	2	MP:0004481
MousePheno	venoocclusion	LPA PLG	2.93e-04	7	53	2	MP:0006137
MousePheno	peptic ulcer	LPA PLG	2.93e-04	7	53	2	MP:0003301
MousePheno	decreased keratinocyte migration	LPA PLG	3.89e-04	8	53	2	MP:0012194
MousePheno	abnormal circulating fibrinogen level	LPA PLG	3.89e-04	8	53	2	MP:0010213
MousePheno	decreased susceptibility to induced choroidal neovascularization	LPA PLG	6.22e-04	10	53	2	MP:0003434
MousePheno	abnormal kidney thrombosis	LPA PLG	6.22e-04	10	53	2	MP:0011507
MousePheno	abnormal keratinocyte migration	LPA PLG	7.59e-04	11	53	2	MP:0012192
MousePheno	abnormal intestine physiology	MST1 RAG2 LPA RORC MST1L PLG	8.67e-04	297	53	6	MP:0010155
Domain	Kringle	MST1 LPA MST1L PLG	2.37e-07	17	61	4	IPR000001
Domain	Kringle_CS	MST1 LPA MST1L PLG	2.37e-07	17	61	4	IPR018056
Domain	KRINGLE_2	MST1 LPA MST1L PLG	2.37e-07	17	61	4	PS50070
Domain	Kringle	MST1 LPA MST1L PLG	2.37e-07	17	61	4	PF00051
Domain	KRINGLE_1	MST1 LPA MST1L PLG	2.37e-07	17	61	4	PS00021
Domain	KR	MST1 LPA MST1L PLG	2.37e-07	17	61	4	SM00130
Domain	PAN_AP	MST1 MST1L PLG	3.30e-07	5	61	3	SM00473
Domain	AGC-kinase_C	GRK2 GRK3 PKN1 PKN2 CIT	1.06e-06	56	61	5	IPR000961
Domain	AGC_KINASE_CTER	GRK2 GRK3 PKN1 PKN2 CIT	1.06e-06	56	61	5	PS51285
Domain	S_TK_X	GRK2 GRK3 PKN1 PKN2 CIT	1.06e-06	56	61	5	SM00133
Domain	PAN	MST1 MST1L PLG	1.15e-06	7	61	3	PS50948
Domain	Pan_app	MST1 MST1L PLG	1.15e-06	7	61	3	IPR003609
Domain	PAN_1	MST1 MST1L PLG	1.15e-06	7	61	3	PF00024
Domain	Gal_Oxase/kelch_b-propeller	RAG2 GAN KLHL18 KLHL22 KLHL4	1.37e-06	59	61	5	IPR011043
Domain	Kringle-like	MST1 LPA MST1L PLG	3.46e-06	32	61	4	IPR013806
Domain	MORN	JPH1 JPH4 MORN1	1.18e-05	14	61	3	SM00698
Domain	MORN	JPH1 JPH4 MORN1	1.47e-05	15	61	3	IPR003409
Domain	MORN	JPH1 JPH4 MORN1	1.47e-05	15	61	3	PF02493
Domain	TRANSFERRIN_LIKE_1	MELTF LTF	3.14e-05	3	61	2	PS00205
Domain	TRANSFERRIN_LIKE_2	MELTF LTF	3.14e-05	3	61	2	PS00206
Domain	TRANSFERRIN_LIKE_3	MELTF LTF	3.14e-05	3	61	2	PS00207
Domain	Transferrin_Fe_BS	MELTF LTF	3.14e-05	3	61	2	IPR018195
Domain	Transferrin	MELTF LTF	3.14e-05	3	61	2	PF00405
Domain	Transferrin	MELTF LTF	3.14e-05	3	61	2	IPR016357
Domain	TR_FER	MELTF LTF	3.14e-05	3	61	2	SM00094
Domain	Transferrin-like_dom	MELTF LTF	3.14e-05	3	61	2	IPR001156
Domain	TRANSFERRIN_LIKE_4	MELTF LTF	3.14e-05	3	61	2	PS51408
Domain	Kelch	GAN KLHL18 KLHL22 KLHL4	3.83e-05	58	61	4	SM00612
Domain	BACK	GAN KLHL18 KLHL22 KLHL4	4.38e-05	60	61	4	SM00875
Domain	BACK	GAN KLHL18 KLHL22 KLHL4	4.68e-05	61	61	4	PF07707
Domain	BACK	GAN KLHL18 KLHL22 KLHL4	4.68e-05	61	61	4	IPR011705
Domain	Junctophilin	JPH1 JPH4	6.27e-05	4	61	2	IPR017191
Domain	PGM_PMM_III	PGM2L1 PGM5	6.27e-05	4	61	2	PF02880
Domain	A-D-PHexomutase_a/b/a-III	PGM2L1 PGM5	6.27e-05	4	61	2	IPR005846
Domain	Kelch_1	GAN KLHL18 KLHL22 KLHL4	8.04e-05	70	61	4	PF01344
Domain	Kelch_1	GAN KLHL18 KLHL22 KLHL4	8.04e-05	70	61	4	IPR006652
Domain	PGM_PMM	PGM2L1 PGM5	1.04e-04	5	61	2	PS00710
Domain	PGM_PMM_II	PGM2L1 PGM5	1.04e-04	5	61	2	PF02879
Domain	PGM_PMM_I	PGM2L1 PGM5	1.04e-04	5	61	2	PF02878
Domain	PGM_PMM_IV	PGM2L1 PGM5	1.04e-04	5	61	2	PF00408
Domain	-	PGM2L1 PGM5	1.04e-04	5	61	2	3.40.120.10
Domain	A-D-PHexomutase_a/b/a-I/II/III	PGM2L1 PGM5	1.04e-04	5	61	2	IPR016055
Domain	-	PGM2L1 PGM5	1.04e-04	5	61	2	3.30.310.50
Domain	-	PKN1 PKN2	1.04e-04	5	61	2	1.10.287.160
Domain	A-D-PHexomutase_a/b/a-I	PGM2L1 PGM5	1.04e-04	5	61	2	IPR005844
Domain	A-D-PHexomutase_a/b/a-II	PGM2L1 PGM5	1.04e-04	5	61	2	IPR005845
Domain	A-D-PHexomutase_C	PGM2L1 PGM5	1.04e-04	5	61	2	IPR005843
Domain	Alpha-D-phosphohexomutase_SF	PGM2L1 PGM5	1.04e-04	5	61	2	IPR005841
Domain	Ser/Thr_kinase_AS	STK36 GRK2 GRK3 PKN1 PKN2 CIT NEK9	1.58e-04	357	61	7	IPR008271
Domain	S_TKc	STK36 GRK2 GRK3 PKN1 PKN2 CIT NEK9	1.64e-04	359	61	7	SM00220
Domain	PROTEIN_KINASE_ST	STK36 GRK2 GRK3 PKN1 PKN2 CIT NEK9	1.72e-04	362	61	7	PS00108
Domain	Gal_Oxidase_b-propeller	GAN KLHL18 KLHL4	1.85e-04	34	61	3	IPR015916
Domain	GPCR_kinase	GRK2 GRK3	2.18e-04	7	61	2	IPR000239
Domain	Hr1	PKN1 PKN2	2.18e-04	7	61	2	SM00742
Domain	Pkinase	STK36 GRK2 GRK3 PKN1 PKN2 CIT NEK9	2.35e-04	381	61	7	PF00069
Domain	Pkinase_C	PKN1 PKN2 CIT	2.38e-04	37	61	3	IPR017892
Domain	HR1	PKN1 PKN2	2.90e-04	8	61	2	PF02185
Domain	Pkinase_C	PKN1 PKN2 CIT	3.48e-04	42	61	3	PF00433
Domain	BTB-kelch_protein	GAN KLHL18 KLHL22	3.73e-04	43	61	3	IPR017096
Domain	Peptidase_S1A	MST1 LPA MST1L PLG	5.08e-04	113	61	4	IPR001314
Domain	-	RAG2 GAN KLHL22	5.16e-04	48	61	3	2.120.10.80
Domain	TRYPSIN_DOM	MST1 LPA MST1L PLG	5.43e-04	115	61	4	PS50240
Domain	Tryp_SPc	MST1 LPA MST1L PLG	5.80e-04	117	61	4	SM00020
Domain	Trypsin	MST1 LPA MST1L PLG	6.58e-04	121	61	4	PF00089
Domain	Trypsin_dom	MST1 LPA MST1L PLG	6.58e-04	121	61	4	IPR001254
Domain	Peptidase_S1_PA	MST1 LPA MST1L PLG	6.99e-04	123	61	4	IPR009003
Domain	PROTEIN_KINASE_ATP	STK36 GRK2 GRK3 PKN1 PKN2 CIT NEK9	7.18e-04	459	61	7	PS00107
Domain	Kelch-typ_b-propeller	RAG2 GAN KLHL22	7.71e-04	55	61	3	IPR015915
Domain	BTB	GAN KLHL18 KLHL22 KLHL4	8.85e-04	131	61	4	PF00651
Domain	Prot_kinase_dom	STK36 GRK2 GRK3 PKN1 PKN2 CIT NEK9	1.04e-03	489	61	7	IPR000719
Domain	PROTEIN_KINASE_DOM	STK36 GRK2 GRK3 PKN1 PKN2 CIT NEK9	1.09e-03	493	61	7	PS50011
Domain	Protein_kinase_ATP_BS	STK36 GRK2 GRK3 PKN1 PKN2 CIT	1.45e-03	379	61	6	IPR017441
Domain	BTB	GAN KLHL18 KLHL22 KLHL4	1.85e-03	160	61	4	PS50097
Domain	Kinase-like_dom	STK36 GRK2 GRK3 PKN1 PKN2 CIT NEK9	1.87e-03	542	61	7	IPR011009
Domain	BTB	GAN KLHL18 KLHL22 KLHL4	2.84e-03	180	61	4	SM00225
Domain	HR1_rho-bd	PKN1 PKN2	3.00e-03	25	61	2	IPR011072
Domain	BTB/POZ_dom	GAN KLHL18 KLHL22 KLHL4	3.13e-03	185	61	4	IPR000210
Pubmed	Update on the Kelch-like (KLHL) gene family.	GAN KLHL18 KLHL22 KLHL4	8.82e-07	41	62	4	23676014
Pubmed	Short-term inhibition of fibrinolytic system restores locomotor function after spinal cord injury in mice.	LPA PLG	3.13e-06	2	62	2	31690812
Pubmed	Blood-derived plasminogen drives brain inflammation and plaque deposition in a mouse model of Alzheimer's disease.	LPA PLG	3.13e-06	2	62	2	30254165
Pubmed	Plasminogen deficiency exacerbates skeletal muscle loss during mechanical unloading in developing mice.	LPA PLG	3.13e-06	2	62	2	38328826
Pubmed	Cloning of GRK2 cDNA from S49 murine lymphoma cells.	GRK2 GRK3	3.13e-06	2	62	2	8638670
Pubmed	Reduced transplant arteriosclerosis in plasminogen-deficient mice.	LPA PLG	3.13e-06	2	62	2	9819364
Pubmed	Persistent corneal haze after excimer laser photokeratectomy in plasminogen-deficient mice.	LPA PLG	3.13e-06	2	62	2	10634603
Pubmed	Thrombomodulin functions as a plasminogen receptor to modulate angiogenesis.	LPA PLG	3.13e-06	2	62	2	23943648
Pubmed	In vivo plasminogen deficiency reduces fat accumulation.	LPA PLG	3.13e-06	2	62	2	12083480
Pubmed	Polymorphonuclear leukocyte phagocytic function increases in plasminogen knockout mice.	LPA PLG	3.13e-06	2	62	2	18420257
Pubmed	Plasminogen deficiency causes severe thrombosis but is compatible with development and reproduction.	LPA PLG	3.13e-06	2	62	2	7705657
Pubmed	Nucleocytoplasmic coagulation: an injury-induced aggregation event that disulfide crosslinks proteins and facilitates their removal by plasmin.	LPA PLG	3.13e-06	2	62	2	23041318
Pubmed	Plasminogen alleles influence susceptibility to invasive aspergillosis.	LPA PLG	3.13e-06	2	62	2	18566672
Pubmed	Mst1 regulates post-infarction cardiac injury through the JNK-Drp1-mitochondrial fission pathway.	MST1 MST1L	3.13e-06	2	62	2	29760744
Pubmed	A novel role for plasmin-mediated degradation of opsonizing antibody in the evasion of host immunity by virulent, but not attenuated, Francisella tularensis.	LPA PLG	3.13e-06	2	62	2	19752236
Pubmed	Dissecting the roles of GRK2 and GRK3 in μ-opioid receptor internalization and β-arrestin2 recruitment using CRISPR/Cas9-edited HEK293 cells.	GRK2 GRK3	3.13e-06	2	62	2	33060647
Pubmed	Plasminogen Tochigi: inactive plasmin resulting from replacement of alanine-600 by threonine in the active site.	LPA PLG	3.13e-06	2	62	2	6216475
Pubmed	The generation and characterization of mice expressing a plasmin-inactivating active site mutation.	LPA PLG	3.13e-06	2	62	2	20653841
Pubmed	Influence of plasminogen deficiency on the contribution of polymorphonuclear leucocytes to fibrin/ogenolysis: studies in plasminogen knock-out mice.	LPA PLG	3.13e-06	2	62	2	12428098
Pubmed	Tissue-type plasminogen activator is a neuroprotectant in the mouse hippocampus.	LPA PLG	3.13e-06	2	62	2	20440070
Pubmed	Plasminogen deficiency causes reduced corticospinal axonal plasticity and functional recovery after stroke in mice.	LPA PLG	3.13e-06	2	62	2	24732409
Pubmed	A central role for plasminogen in the inflammatory response to biomaterials.	LPA PLG	3.13e-06	2	62	2	15456492
Pubmed	Cloning, sequencing, and expression of human macrophage stimulating protein (MSP, MST1) confirms MSP as a member of the family of kringle proteins and locates the MSP gene on chromosome 3.	MST1 MST1L	3.13e-06	2	62	2	8393443
Pubmed	Plasminogen promotes macrophage phagocytosis in mice.	LPA PLG	3.13e-06	2	62	2	24876560
Pubmed	Plasminogen is a joint-specific positive or negative determinant of arthritis pathogenesis in mice.	LPA PLG	3.13e-06	2	62	2	24574269
Pubmed	G protein--coupled receptor kinases.	GRK2 GRK3	3.13e-06	2	62	2	8035170
Pubmed	Spontaneous development of otitis media in plasminogen-deficient mice.	LPA PLG	3.13e-06	2	62	2	16956791
Pubmed	Staphylococcus aureus manganese transport protein C (MntC) is an extracellular matrix- and plasminogen-binding protein.	LPA PLG	3.13e-06	2	62	2	25409527
Pubmed	The mouse plasminogen locus maps to the recombination breakpoints of the tLub2 and TtOrl partial t haplotypes but is not at the tw73 locus.	LPA PLG	3.13e-06	2	62	2	1543918
Pubmed	Restoration of thrombolytic potential in plasminogen-deficient mice by bolus administration of plasminogen.	LPA PLG	3.13e-06	2	62	2	8704243
Pubmed	Plasmin(ogen) promotes renal interstitial fibrosis by promoting epithelial-to-mesenchymal transition: role of plasmin-activated signals.	LPA PLG	3.13e-06	2	62	2	17267741
Pubmed	Protein kinase C-related kinase 1 and 2 play an essential role in thromboxane-mediated neoplastic responses in prostate cancer.	PKN1 PKN2	3.13e-06	2	62	2	26296974
Pubmed	MSP is a negative regulator of inflammation and lipogenesis in ex vivo models of non-alcoholic steatohepatitis.	MST1 MST1L	3.13e-06	2	62	2	27609031
Pubmed	Plasmin promotes foam cell formation by increasing macrophage catabolism of aggregated low-density lipoprotein.	LPA PLG	3.13e-06	2	62	2	23702659
Pubmed	Hepatocyte growth factor-like protein is required for prostate tumor growth in the TRAMP mouse model.	MST1 MST1L	3.13e-06	2	62	2	24980820
Pubmed	Apolipoprotein(a) inhibits the conversion of Glu-plasminogen to Lys-plasminogen on the surface of vascular endothelial and smooth muscle cells.	LPA PLG	3.13e-06	2	62	2	29990619
Pubmed	Reduction of experimental diabetic vascular leakage by delivery of angiostatin with a recombinant adeno-associated virus vector.	LPA PLG	3.13e-06	2	62	2	17293777
Pubmed	Plasminogen plays a crucial role in bone repair.	LPA PLG	3.13e-06	2	62	2	23456978
Pubmed	Noncoding transcription controls downstream promoters to regulate T-cell receptor alpha recombination.	RAG2 RORC	3.13e-06	2	62	2	17882258
Pubmed	Disruption of the plasminogen gene in mice abolishes wound healing after myocardial infarction.	LPA PLG	3.13e-06	2	62	2	10854210
Pubmed	Gender affects skin wound healing in plasminogen deficient mice.	LPA PLG	3.13e-06	2	62	2	23527289
Pubmed	Mst1 deletion reduces hyperglycemia-mediated vascular dysfunction via attenuating mitochondrial fission and modulating the JNK signaling pathway.	MST1 MST1L	3.13e-06	2	62	2	31206688
Pubmed	Dengue virus-induced autoantibodies bind to plasminogen and enhance its activation.	LPA PLG	3.13e-06	2	62	2	22079981
Pubmed	Plasminogen deficiency differentially affects recruitment of inflammatory cell populations in mice.	LPA PLG	3.13e-06	2	62	2	9490683
Pubmed	Kringle 5 of human plasminogen suppresses hepatocellular carcinoma growth both in grafted and xenografted mice by anti-angiogenic activity.	LPA PLG	3.13e-06	2	62	2	16481742
Pubmed	Apolipoprotein(a) inhibits the conversion of Glu-plasminogen to Lys-plasminogen: a novel mechanism for lipoprotein(a)-mediated inhibition of plasminogen activation.	LPA PLG	3.13e-06	2	62	2	18983515
Pubmed	Plasminogen Regulates Fracture Repair by Promoting the Functions of Periosteal Mesenchymal Progenitors.	LPA PLG	3.13e-06	2	62	2	34378815
Pubmed	Plasmin generation plays different roles in the formation and removal of arterial and venous thrombus in mice.	LPA PLG	3.13e-06	2	62	2	11848464
Pubmed	Effects of disruption of the plasminogen gene on thrombosis, growth, and health in mice.	LPA PLG	3.13e-06	2	62	2	7586361
Pubmed	Plasminogen/plasmin modulates bone metabolism by regulating the osteoblast and osteoclast function.	LPA PLG	3.13e-06	2	62	2	21239499
Pubmed	Plasminogen-independent initiation of the pro-urokinase activation cascade in vivo. Activation of pro-urokinase by glandular kallikrein (mGK-6) in plasminogen-deficient mice.	LPA PLG	3.13e-06	2	62	2	10642175
Pubmed	Plasminogen mRNA induction in the mouse brain after kainate excitation: codistribution with plasminogen activator inhibitor-2 (PAI-2) mRNA.	LPA PLG	3.13e-06	2	62	2	12225871
Pubmed	Fibrinogen deficiency reduces vascular accumulation of apolipoprotein(a) and development of atherosclerosis in apolipoprotein(a) transgenic mice.	LPA PLG	3.13e-06	2	62	2	9770530
Pubmed	Structure of the human D1F15S1A locus: a chromosome 1 locus with 97% identity to the chromosome 3 gene coding for hepatocyte growth factor-like protein.	MST1 MST1L	3.13e-06	2	62	2	10728827
Pubmed	Genetically selected Marchigian Sardinian alcohol-preferring (msP) rats: an animal model to study the neurobiology of alcoholism.	MST1 MST1L	3.13e-06	2	62	2	16961763
Pubmed	Cloning and expression patterns of two members of a novel protein-kinase-C-related kinase family.	PKN1 PKN2	3.13e-06	2	62	2	7851406
Pubmed	Plasminogen activation is required for the development of radiation-induced dermatitis.	LPA PLG	3.13e-06	2	62	2	30323258
Pubmed	Plasminogen deficiency suppresses pancreatic ductal adenocarcinoma disease progression.	LPA PLG	3.13e-06	2	62	2	37971174
Pubmed	The plasminogen activation system enhances brain and heart invasion in murine relapsing fever borreliosis.	LPA PLG	3.13e-06	2	62	2	9884337
Pubmed	Colonic Lesions, Cytokine Profiles, and Gut Microbiota in Plasminogen-Deficient Mice.	LPA PLG	3.13e-06	2	62	2	26473342
Pubmed	Inhibiting endothelial cell Mst1 attenuates acute lung injury in mice.	MST1 MST1L	3.13e-06	2	62	2	39253972
Pubmed	Nonfibrinolytic functions of plasminogen.	LPA PLG	3.13e-06	2	62	2	10816371
Pubmed	Regulation of T cell receptor alpha gene assembly by a complex hierarchy of germline Jalpha promoters.	RAG2 RORC	3.13e-06	2	62	2	15806105
Pubmed	The Phosphoinositide Kinase PIKfyve Promotes Cathepsin-S-Mediated Major Histocompatibility Complex Class II Antigen Presentation.	PIKFYVE CTSS	3.13e-06	2	62	2	30612035
Pubmed	Plasminogen is a critical regulator of cutaneous wound healing.	LPA PLG	3.13e-06	2	62	2	26791370
Pubmed	Cerebral ischemia-reperfusion is modulated by macrophage-stimulating 1 through the MAPK-ERK signaling pathway.	MST1 MST1L	3.13e-06	2	62	2	32017081
Pubmed	Selection of mutant µplasmin for amyloid-β cleavage in vivo.	LPA PLG	3.13e-06	2	62	2	32694536
Pubmed	Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma.	LPA PLG	3.13e-06	2	62	2	7525077
Pubmed	A distinct role of neutrophil lactoferrin in RelA/p65 phosphorylation on Ser536 by recruiting TNF receptor-associated factors to IkappaB kinase signaling complex.	RELA LTF	3.13e-06	2	62	2	17947640
Pubmed	Altered airway and cardiac responses in mice lacking G protein-coupled receptor kinase 3.	GRK2 GRK3	3.13e-06	2	62	2	10198406
Pubmed	Mst1 inhibition attenuates non-alcoholic fatty liver disease via reversing Parkin-related mitophagy.	MST1 MST1L	3.13e-06	2	62	2	30708325
Pubmed	Functional consequences of the macrophage stimulating protein 689C inflammatory bowel disease risk allele.	MST1 MST1L	3.13e-06	2	62	2	24409221
Pubmed	Contrasting roles of plasminogen deficiency in different rheumatoid arthritis models.	LPA PLG	3.13e-06	2	62	2	16052596
Pubmed	Functional corpora lutea are formed in matrix metalloproteinase inhibitor-treated plasminogen-deficient mice.	LPA PLG	3.13e-06	2	62	2	17122079
Pubmed	Novel roles of PRK1 and PRK2 in cilia and cancer biology.	PKN1 PKN2	3.13e-06	2	62	2	32127582
Pubmed	Melatonin alleviates postinfarction cardiac remodeling and dysfunction by inhibiting Mst1.	MST1 MST1L	3.13e-06	2	62	2	27696525
Pubmed	Role of plasminogen in propagation of scrapie.	LPA PLG	3.13e-06	2	62	2	16103174
Pubmed	Differential expression of oxidized/native lipoprotein(a) and plasminogen in human carotid and cerebral artery plaques.	LPA PLG	3.13e-06	2	62	2	21300353
Pubmed	G-protein coupled receptor kinase 2 and 3 expression in human detrusor cultured smooth muscle cells.	GRK2 GRK3	3.13e-06	2	62	2	11762794
Pubmed	Beta-amyloid (Abeta) causes detachment of N1E-115 neuroblastoma cells by acting as a scaffold for cell-associated plasminogen activation.	LPA PLG	3.13e-06	2	62	2	15737740
Pubmed	Selective behaviors altered in plasminogen-deficient mice are reconstituted with intracerebroventricular injection of plasminogen.	LPA PLG	3.13e-06	2	62	2	11306011
Pubmed	Localization of regulatory elements mediating constitutive and cytokine-stimulated plasminogen gene expression.	LPA PLG	3.13e-06	2	62	2	12149246
Pubmed	Plasminogen deficiency attenuates postnatal erythropoiesis in male C57BL/6 mice through decreased activity of the LH-testosterone axis.	LPA PLG	3.13e-06	2	62	2	22056679
Pubmed	Hepatocyte-specific expression of the mouse hepatocyte growth factor-like protein.	MST1 MST1L	3.13e-06	2	62	2	8340069
Pubmed	Protective effects of plasmin(ogen) in a mouse model of Staphylococcus aureus-induced arthritis.	LPA PLG	3.13e-06	2	62	2	18311818
Pubmed	Biological effects of targeted inactivation of hepatocyte growth factor-like protein in mice.	MST1 MST1L	3.13e-06	2	62	2	9486989
Pubmed	Localization of plasminogen in mouse hippocampus, cerebral cortex, and hypothalamus.	LPA PLG	3.13e-06	2	62	2	21190118
Pubmed	The lack of binding of VEK-30, an internal peptide from the group A streptococcal M-like protein, PAM, to murine plasminogen is due to two amino acid replacements in the plasminogen kringle-2 domain.	LPA PLG	3.13e-06	2	62	2	18039665
Pubmed	Reduced metastasis of Polyoma virus middle T antigen-induced mammary cancer in plasminogen-deficient mice.	LPA PLG	3.13e-06	2	62	2	9671388
Pubmed	A physiological function for apolipoprotein(a): a natural regulator of the inflammatory response.	LPA PLG	3.13e-06	2	62	2	18997104
Pubmed	Growth and behavioral development in plasminogen gene-targeted mice.	LPA PLG	3.13e-06	2	62	2	10885855
Pubmed	Cellular density regulation of plasminogen gene expression in mouse hepatocytes.	LPA PLG	3.13e-06	2	62	2	12559391
Pubmed	Role for rearranged variable gene segments in directing secondary T cell receptor alpha recombination.	RAG2 RORC	3.13e-06	2	62	2	17210914
Pubmed	Physiologic variations in blood plasminogen levels affect outcomes after acute cerebral thromboembolism in mice: a pathophysiologic role for microvascular thrombosis.	LPA PLG	3.13e-06	2	62	2	27319402
Pubmed	Plasminogen is a critical host pathogenicity factor for group A streptococcal infection.	LPA PLG	3.13e-06	2	62	2	15333838
Pubmed	Treatment with XMU-MP-1 erases hyperglycaemic memory in hearts of diabetic mice.	MST1 MST1L	3.13e-06	2	62	2	33887258
Pubmed	Apo(a) promotes thrombosis in a vascular injury model by a mechanism independent of plasminogen.	LPA PLG	3.13e-06	2	62	2	16150044
Pubmed	Plasminogen has a broad extrahepatic distribution.	LPA PLG	3.13e-06	2	62	2	11916082
Pubmed	Unaltered prion protein cleavage in plasminogen-deficient mice.	LPA PLG	3.13e-06	2	62	2	16543819
Pubmed	Essential role of DNA-PKcs and plasminogen for the development of doxorubicin-induced glomerular injury in mice.	LPA PLG	3.13e-06	2	62	2	34423816
Cytoband	Ensembl 112 genes in cytogenetic band chr6q26	LPA PLG	2.13e-04	16	62	2	chr6q26
Cytoband	6q26	LPA PLG	2.71e-04	18	62	2	6q26
Cytoband	Ensembl 112 genes in cytogenetic band chr3p21	MST1 TKT LTF KLHL18	8.97e-04	316	62	4	chr3p21
GeneFamily	Kelch like\|BTB domain containing	GAN KLHL18 KLHL22 KLHL4	1.11e-06	42	34	4	617
GeneFamily	Transferrins	MELTF LTF	1.03e-05	3	34	2	908
GeneFamily	Basic leucine zipper proteins\|BTB domain containing	GAN KLHL18 KLHL22 KLHL4	1.13e-04	134	34	4	861
GeneFamily	C2 domain containing protein kinases	PKN1 PKN2	1.53e-04	10	34	2	835
Coexpression	CAIRO_LIVER_DEVELOPMENT_DN	MST1 LPA PKN2 HAGH MST1L LTF PLG	1.54e-06	239	62	7	MM1274
Coexpression	FAN_EMBRYONIC_CTX_BRAIN_MYELOID	GRK2 TKT VCAN CTSS CLEC2B	1.98e-05	139	62	5	M39044
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FNDC1 VCAN NAV3 GREB1 PTGER3	5.50e-06	182	62	5	3dfa9187e9d2bab1d199079d29209c4648220ada
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FNDC1 VCAN NAV3 LTBP1 KLHL4	6.96e-06	191	62	5	107113b930d9ad171f1b2aa20df4567c94fae7d8
ToppCell	PBMC-Mild-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_1\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	GRK2 GRK3 TKT VCAN CTSS	6.96e-06	191	62	5	c9f3bdb5c0a90268cab24a0fe4c3a8290fcedeb8
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FNDC1 VCAN NAV3 LTBP1 KLHL4	6.96e-06	191	62	5	bc353a79a1d11ca52bba5e3874a80d432e1a7715
ToppCell	PBMC-Mild-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_1\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	GRK2 GRK3 TKT VCAN CTSS	7.14e-06	192	62	5	b86476037ddf8904c1d8a6b3763af7242c031cf3
ToppCell	PBMC-Severe-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_1\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	GRK2 GRK3 TKT VCAN CTSS	7.32e-06	193	62	5	4fb020f11fd7aff06952bfeaabc79b2c7b8873f6
ToppCell	PBMC-Severe-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_1\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	GRK2 GRK3 TKT VCAN CTSS	7.50e-06	194	62	5	885355ebe98e974f841cc59dce3b5228c642c5d0
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-Mono-Mono_naive-Z\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	GRK2 TKT VCAN RPS24 CTSS	7.50e-06	194	62	5	b191851b2287afc8c47320f5488fd22e2a454aa6
ToppCell	Smart-seq2-bone_marrow_(Smart-seq2)-myeloid\|bone_marrow_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	GRK2 TKT VCAN LTF CTSS	7.69e-06	195	62	5	b0dbaae86f5703ab62f925e0f36500274044884a
ToppCell	COVID-19_Mild-Classical_Monocyte-cMono_3\|COVID-19_Mild / Disease condition and Cell class	GRK2 GRK3 TKT VCAN CTSS	7.89e-06	196	62	5	f245e929a286cb097130572e1027b4f01be8b04d
ToppCell	10x_3'_v3-blood_(10x_3'_v3)-myeloid-myeloid_monocytic\|blood_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	GRK3 TKT VCAN RPS24 CTSS	8.28e-06	198	62	5	f3346c26b9647a199faf3cd7ab19c3a963dbabc2
ToppCell	10x3'2.3-week_12-13-Myeloid_neutrophil-granulo-neutrophil\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	TKT VCAN RPS24 LTF CTSS	8.28e-06	198	62	5	66d65951a6a39cc5d5ba5f96fdf3eb61c74ac616
ToppCell	distal-1-mesenchymal-Mesothelial\|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	MST1 FNDC1 MELTF PTGER3 KLHL4	8.49e-06	199	62	5	8dd5b411d2f1626830b77a1616cc3fb67dc59338
ToppCell	10x5'v1-week_14-16-Myeloid_monocytic\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	GRK2 TKT VCAN RPS24 CTSS	8.49e-06	199	62	5	5caaf66b6cddcc8f0d0aee3c9ba80d02075e87e5
ToppCell	10x5'v1-week_14-16-Myeloid_monocytic-monocyte\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	GRK2 TKT VCAN RPS24 CTSS	8.49e-06	199	62	5	7f5d47e49776114d9f4a42017fead9eeb415a94c
ToppCell	Sepsis-ICU-NoSEP-Lymphocyte-T/NK-dn_T\|ICU-NoSEP / Disease, condition lineage and cell class	MED19 LHFPL4 CDADC1 PGM2L1 DTHD1	8.49e-06	199	62	5	7fb211f803a8b3a2cfa9455386abea08131c6b52
ToppCell	PND01-03-samps-Mesenchymal-Myofibroblast-myofibroblast_-_mature_-_B\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	FNDC1 VCAN GAN GREB1	4.12e-05	138	62	4	8d70e64843f7c3be8ee4203cc126fdf1001f0df5
ToppCell	IIF-Lymphocyte-T_NK-dnT\|IIF / Disease, Lineage and Cell Type	MELTF USP24 PGM2L1 DTHD1	5.13e-05	146	62	4	d0f361662db5f7be26104346e8431f7e30c5ce3a
ToppCell	ICU-NoSEP-Lymphocyte-T_NK-dnT\|ICU-NoSEP / Disease, Lineage and Cell Type	MED19 LHFPL4 PGM2L1 DTHD1	6.80e-05	157	62	4	c02500cf9255737c6229ec729803acd568485fb4
ToppCell	PND14-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-CD8_T-CD8_T_prolif\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MORN1 PKN1 RORC SPRTN	7.14e-05	159	62	4	e9c51e611ebd427bbe51e3e036c14122c36ea372
ToppCell	PND10-Immune-Immune_Myeloid-DC-cDC1\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MST1 SYNGR2 RPS24 CTSS	7.14e-05	159	62	4	7bb76324d2026d4bd348126cb169c8411f0d7145
ToppCell	facs-Large_Intestine-Proximal-24m-Epithelial-Enterocyte_(Proximal)\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPT NCOA7 RHOF CTSS	8.24e-05	165	62	4	ce79d217df88035457cd58f679e72dd98722ae22
ToppCell	facs-Large_Intestine-Proximal-18m-Epithelial-Enterocyte_(Proximal)\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPT NCOA7 RHOF CTSS	8.44e-05	166	62	4	22b31acbbef1936ce19b393cf880c63ea2fa0f1b
ToppCell	facs-Thymus-nan-3m-Myeloid-macrophage\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TKFC GRK3 SYNGR2 CTSS	8.84e-05	168	62	4	d72cd8238fa793bb3e4add4c59eaaaadcea9930d
ToppCell	facs-Thymus-nan-3m-Myeloid-macrophage\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TKFC GRK3 SYNGR2 CTSS	8.84e-05	168	62	4	c34c52165485f612add7a3e35a175d5a6e365e7c
ToppCell	TCGA-Endometrium-Solid_Tissue_Normal-Endometrium_normal_tissue-Endometrium-7\|TCGA-Endometrium / Sample_Type by Project: Shred V9	JPH4 PTGER3 PGM5 KLHL4	8.84e-05	168	62	4	a97e8e07ba949b30805aeed5f60fa5e092b9d3d4
ToppCell	facs-Thymus-nan-3m-Myeloid\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TKFC GRK3 SYNGR2 CTSS	8.84e-05	168	62	4	d2afc097ae1243574210be6a751685f949ea941a
ToppCell	TCGA-Endometrium-Solid_Tissue_Normal-Endometrium_normal_tissue-Endometrium\|TCGA-Endometrium / Sample_Type by Project: Shred V9	JPH4 PTGER3 PGM5 KLHL4	9.25e-05	170	62	4	cdc19013da7c41d1ed8400a6a643e4c684ff9912
ToppCell	TCGA-Endometrium-Solid_Tissue_Normal\|TCGA-Endometrium / Sample_Type by Project: Shred V9	JPH4 PTGER3 PGM5 KLHL4	9.25e-05	170	62	4	0bde0a40440c7fdf7ba89cac8831d4014e7a4807
ToppCell	TCGA-Endometrium-Solid_Tissue_Normal-Endometrium_normal_tissue\|TCGA-Endometrium / Sample_Type by Project: Shred V9	JPH4 PTGER3 PGM5 KLHL4	9.25e-05	170	62	4	516b38c4ecf6b0b04c5d4f80c510dcc00b328c6f
ToppCell	facs-Large_Intestine-Proximal-3m-Epithelial-Enterocyte_(Proximal)\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPT NCOA7 RHOF CTSS	9.46e-05	171	62	4	5d0d6c1ff610a703ae0b834a12823c5ff9012932
ToppCell	PND14-Immune-Immune_Myeloid-DC\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	GRK3 SYNGR2 RPS24 CTSS	9.46e-05	171	62	4	8772d6349db24de47f089df2032a80345db7177f
ToppCell	Smart-seq2-tissue-resident_(Smart-seq2)-myeloid-myeloid_monocytic-classical_monocyte\|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	GRK2 TKT VCAN CTSS	9.68e-05	172	62	4	4b1d4920f121d063784133969a797c05eb7feaa2
ToppCell	droplet-Mammary_Gland-nan-21m-Endothelial-basal_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	JPH1 RDH16 SGSH KLHL4	1.06e-04	176	62	4	27e5115fae5f0f63b333bc99fbf6a6d4c9182c46
ToppCell	droplet-Lung-21m-Hematologic-myeloid-myeloid_dendritic_cell\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	GRK3 MORN1 SYNGR2 CTSS	1.06e-04	176	62	4	7d1e2627d7ec5ddd6c87c55d2a6879255b76949e
ToppCell	facs-Large_Intestine-Proximal-3m-Epithelial-enterocyte_of_epithelium_of_large_intestine\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPT NCOA7 RHOF CTSS	1.06e-04	176	62	4	7622f5a8e7320cc7b593141854107ecaf4adff7f
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MST1 GPT GREB1 PLG	1.08e-04	177	62	4	2f81b26be89cc2fd8eafadaf7eae3c6ad6521462
ToppCell	droplet-Liver-LIVER-30m-Lymphocytic-B_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FNDC1 NAV3 LTBP1 LTF	1.15e-04	180	62	4	3d95232b5785c705f41e01e3ffe0fa8dce1ff0a7
ToppCell	droplet-Liver-LIVER-30m-Lymphocytic-B_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FNDC1 NAV3 LTBP1 LTF	1.15e-04	180	62	4	47e345359064dc8ceec982b062e47802e728b43f
ToppCell	facs-Bladder-nan-24m-Epithelial-bladder_mesenchymal_cell_(Car3+)\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FNDC1 VCAN NAV3 GREB1	1.15e-04	180	62	4	12537d8a569faa69f474284d2c201475722b8ca1
ToppCell	PBMC-Control-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_1\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	TKT VCAN RPS24 CTSS	1.18e-04	181	62	4	7225361d8854de6be34d40845e50978d93a88a5d
ToppCell	3'-Child04-06-SmallIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FNDC1 VCAN NAV3 PTGER3	1.18e-04	181	62	4	e1ae9ada60ec89e7a7cde9c231c1a099ed2ffecc
ToppCell	COVID-19_Severe-Classical_Monocyte-cMono_1\|COVID-19_Severe / Disease condition and Cell class	GRK2 GRK3 VCAN CTSS	1.18e-04	181	62	4	0d07a67e8ee3bca687b378afbc4044434e63556d
ToppCell	facs-Lung-EPCAM-18m-Lymphocytic-B_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RPS24 LY6K RHOF CTSS	1.18e-04	181	62	4	ce30724788d9b5c6dfa4f9f8d318c3d2565165ed
ToppCell	facs-Lung-EPCAM-18m-Lymphocytic-B_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RPS24 LY6K RHOF CTSS	1.18e-04	181	62	4	2c2b812cdd350271935d7007665c26093756ebee
ToppCell	PBMC-Control-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_1\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TKT VCAN RPS24 CTSS	1.18e-04	181	62	4	fbab54d17796afbbad8127ade8ac580929ad7d36
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MST1 GPT GREB1 PLG	1.20e-04	182	62	4	4a9c13932e7163fd37a3dcc4c6ca3bbea5372459
ToppCell	droplet-Limb_Muscle-nan-24m-Lymphocytic-B_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CERK RPS24 RHOF CTSS	1.20e-04	182	62	4	6946ab8d91fb8dce5af065f57a13659b8d97ed5c
ToppCell	E18.5-samps-Mesenchymal-Myofibroblast\|E18.5-samps / Age Group, Lineage, Cell class and subclass	JPH1 FNDC1 VCAN GREB1	1.23e-04	183	62	4	de08f9ea02b7244d5a8788064631d10f06565337
ToppCell	normal-na-Lymphocytic_T-CytoT_GZMK+-male\|normal / PBMC cell types (v2) per disease, treatment status, and sex	NCOA7 DTHD1 CLEC2B KLHL4	1.23e-04	183	62	4	79defd22b3194dad16db55b9bdd220c09c1e6b90
ToppCell	3'_v3-bone_marrow-Myeloid_Monocytic-Cycling_mono\|bone_marrow / Manually curated celltypes from each tissue	TKT VCAN PTGER3 CTSS	1.23e-04	183	62	4	f10e72a2e2e6cdc1984f469a60244e5fd8a10095
ToppCell	facs-Lung-24m-Hematologic-myeloid\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	GRK2 GRK3 SYNGR2 CTSS	1.25e-04	184	62	4	c451acfcd8fe28c1f4b1ea334b1129fa84a15c42
ToppCell	Smart-seq2-blood_(Smart-seq2)-myeloid-myeloid_monocytic-monocyte\|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	GRK2 VCAN RPS24 CTSS	1.25e-04	184	62	4	bc0dfe29337f02594e7e0092c9e47dda94b45ad5
ToppCell	droplet-Mammary_Gland-nan-3m-Lymphocytic-B_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CERK SYNGR2 RPS24 CTSS	1.28e-04	185	62	4	bf4dbb5f139566750e50a81eb062ed8b9e5786c3
ToppCell	droplet-Mammary_Gland-nan-3m-Lymphocytic-B_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CERK SYNGR2 RPS24 CTSS	1.28e-04	185	62	4	3d035bb453a5942411da4eb8b3a1ca0961a089b2
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_Arw_fibro_(16)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	LPA LTBP1 PLG PGM5	1.31e-04	186	62	4	4d68ee3d32f7ef884faf402ef92b31b0eb4656f1
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MST1 GPT GREB1 PLG	1.31e-04	186	62	4	a417e1e21313a7e05951038cdef5ac672a9f727c
ToppCell	Control-Fibroblasts-Pathological_FB\|Control / group, cell type (main and fine annotations)	FNDC1 VCAN LTBP1 RPS24	1.34e-04	187	62	4	b7280b8baa0fba9c2b4bff660c240ed96f6ff9b7
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_myocytic-mes_ASM_(13)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	FNDC1 LTBP1 PGM5 KLHL4	1.36e-04	188	62	4	74f7d216209cabdc96b2d46685b0ae017fdcc8fc
ToppCell	droplet-Lung-nan-18m-Endothelial-Lymphatic_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RDH16 NAV3 PGM5 KLHL4	1.36e-04	188	62	4	a6ed43fdd42d681c9fbb2fb368947ab7e41d8d7c
ToppCell	Control-Fibroblasts-Adventitial_FB\|Control / group, cell type (main and fine annotations)	VCAN NAV3 LTBP1 GREB1	1.36e-04	188	62	4	706a26c372add839d947749f0521a0e1f5c9b0ec
ToppCell	droplet-Lung-nan-18m-Endothelial-endothelial_cell_of_lymphatic_vessel\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RDH16 NAV3 PGM5 KLHL4	1.36e-04	188	62	4	54550313db78b3b5b572fa1e67092c8f6f33aab5
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_myocytic-mes_ASM_(13)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	FNDC1 LTBP1 PGM5 KLHL4	1.39e-04	189	62	4	da9ecc0d7b81c1901f30f97bb44112dc85444a66
ToppCell	droplet-Lung-18m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RDH16 NAV3 PGM5 KLHL4	1.42e-04	190	62	4	e80d66ba0d5c263e94c1ab0b89d1dc7b837af3e1
ToppCell	lymphoid-B_cell-Naive_B_cell\|lymphoid / Lineage, cell class and subclass	PIKFYVE GRK3 SYNGR2 CTSS	1.42e-04	190	62	4	b8b05894e811e431d797ac4fa3ccff4963a154e7
ToppCell	droplet-Lung-18m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RDH16 NAV3 PGM5 KLHL4	1.42e-04	190	62	4	f32d66c0e74e0a2a23ecb857c4daf0d8573a806c
ToppCell	lymphoid-B_cell\|lymphoid / Lineage, cell class and subclass	PIKFYVE GRK3 SYNGR2 CTSS	1.42e-04	190	62	4	c451de643ee08c2ff1093e807c65d724237473c5
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22-Myeloid-Monocytic-Classical_Monocyte-Mono_c1-CD14-CCL3\|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)	JPH4 TKT VCAN CTSS	1.42e-04	190	62	4	6cf9a41c1a0fa1ce6a8711caa7c71ff6b55df9e1
ToppCell	droplet-Lung-18m-Endothelial-lymphatic_endothelial\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RDH16 NAV3 PGM5 KLHL4	1.42e-04	190	62	4	b79ffd05806244a9790cd04c66fb4f92c824e69f
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibro-meso-mesothelial_cell-Mesothelium-Mesothelium_L.2.6.0.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MST1 FNDC1 PTGER3 KLHL4	1.42e-04	190	62	4	f39ce1678fc375eb2a3af781ddb772b0f12c5744
ToppCell	10x_3'_v2v3-Non-neoplastic-Lymphoid-NK-NK-G\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	RPS24 PTGER3 RHOF CLEC2B	1.42e-04	190	62	4	a08c854ac91dbbe932b22fe20f79a84563754bab
ToppCell	droplet-Thymus-nan-18m-Lymphocytic-DN_to_DP_transition_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination__)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RAG2 CERK TNRC6B RORC	1.45e-04	191	62	4	4bd9db45e7b5c0d04368e08c8199d390744aa317
ToppCell	facs-Marrow-B-cells\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RAG2 CERK RPS24 CTSS	1.45e-04	191	62	4	f84cd55e6fb112d271d35db11ad7648e03186e46
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-Mono-Mono_naive-E\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	GRK3 TKT VCAN CTSS	1.45e-04	191	62	4	63d4226a8b59f648bdc9f41e4b2d750dfa342034
ToppCell	human_hepatoblastoma-Tumor_cells-T8\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	MST1 LPA HAGH PLG	1.48e-04	192	62	4	e785135262f4c9cc66c403bf362bb34643b212c5
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MST1 GPT GREB1 PLG	1.48e-04	192	62	4	3e1a4cb0d83efd502c8613d41a1692bdda5860ed
ToppCell	metastatic_Lymph_Node-Myeloid_cells-Monocytes\|metastatic_Lymph_Node / Location, Cell class and cell subclass	TKT VCAN RPS24 CTSS	1.51e-04	193	62	4	e67e960a5312ed73c5169795cb282e431866b9c1
ToppCell	Leuk-UTI-Myeloid-CD14_Mono\|Leuk-UTI / Disease, Lineage and Cell Type	TKT VCAN RPS24 CTSS	1.51e-04	193	62	4	d1eac8627d00629ed2e81d3b86778007304efcb7
ToppCell	Smart-seq2-blood_(Smart-seq2)-myeloid\|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	GRK2 TKT VCAN CTSS	1.51e-04	193	62	4	1db487e5f81849740d57cc3e2b5739e8f7581efb
ToppCell	PCW_13-14-Endothelial-Endothelial_mature-endo_venous_(13)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	JPH4 SYNGR2 NAV3 LTF	1.51e-04	193	62	4	84d1c1b7d3a1cb80f175527e3c89a2c3da7657f7
ToppCell	Control-Fibroblasts-Intermediate_pathological_FB\|Control / group, cell type (main and fine annotations)	FNDC1 VCAN NAV3 LTBP1	1.54e-04	194	62	4	03a269f75a481ea54aea8e6444605db8d6df493d
ToppCell	Smart-seq2-lymph_node_(Smart-seq2)-lymphocytic-B_lymphocytic-B_cell\|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	PIKFYVE GRK3 SYNGR2 TNRC6B	1.54e-04	194	62	4	ff661419b697aef51a53fdeac8d37d870d65f491
ToppCell	TCGA-Stomach-Primary_Tumor-Stomach_Adenocarcinoma-Stomach_Adenocarcinoma_-_NOS-3\|TCGA-Stomach / Sample_Type by Project: Shred V9	FNDC1 VCAN NAV3 LTBP1	1.54e-04	194	62	4	2260cd817a6661e5eb6645b0c6786e18fd58371e
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibro-meso-mesothelial_cell-Mesothelium\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MST1 FNDC1 PTGER3 KLHL4	1.54e-04	194	62	4	c578cf7c6b4d6f31f87dde8845de5b3891f16822
ToppCell	healthy_donor-Myeloid-Monocytic-CD16+_Monocyte\|healthy_donor / Disease condition, Lineage, Cell class and subclass	GRK3 TKT SYNGR2 CTSS	1.54e-04	194	62	4	ecf746ef1c5c4d6d9ca06a6d3e3778670b5700c2
ToppCell	medial-Hematologic-Nonclassical_Monocyte\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	GRK2 GRK3 TKT CTSS	1.54e-04	194	62	4	ac203d388a3a3884e316dec0dcbd408e43c6ef6c
ToppCell	medial-2-Hematologic-Nonclassical_Monocyte\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	GRK2 GRK3 TKT CTSS	1.54e-04	194	62	4	202e5070728191c46161fa7d931f00be1c7559d4
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibro-meso\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MST1 FNDC1 PTGER3 KLHL4	1.54e-04	194	62	4	f4286ae7bb8350c42d50727ee8688b80129714f6
ToppCell	Smart-seq2-blood_(Smart-seq2)-myeloid-myeloid_monocytic\|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	GRK2 TKT VCAN CTSS	1.54e-04	194	62	4	a94f9f7179a5733e3c378ff8b337e288785433a1
ToppCell	medial-Hematologic-Nonclassical_Monocyte-2\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	GRK2 GRK3 TKT CTSS	1.54e-04	194	62	4	002cd317732fc6b0d9a72fb46199f71db5a638a7
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibro-meso-mesothelial_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MST1 FNDC1 PTGER3 KLHL4	1.54e-04	194	62	4	87461bd6d7f702c0a0f5e0c8ace3049125a51f9a
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	VCAN NAV3 LTBP1 GREB1	1.57e-04	195	62	4	f54bc4454270ff06e85596f98199372b50d0179f
ToppCell	distal-1-Hematologic-Nonclassical_Monocyte\|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CERK TKT RHOF CTSS	1.57e-04	195	62	4	e1a8171d1af53c2bbda758170c5053d3a3bb6ddd
ToppCell	PBMC-Control-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_2\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	GRK3 TKT VCAN CTSS	1.57e-04	195	62	4	0110b976f98561ecd2e20ff6e7e3960a401bb7c2
ToppCell	metastatic_Lymph_Node-Myeloid_cells-Monocytes\|Myeloid_cells / Location, Cell class and cell subclass	TKT VCAN RPS24 CTSS	1.57e-04	195	62	4	8861c82129f3ef241b1e9fa4825e4621550cee96
ToppCell	Control-Classical_Monocyte-cMono_2\|Control / Disease condition and Cell class	GRK2 TKT VCAN CTSS	1.57e-04	195	62	4	0fea64ee3eedf3929abb0dd9c5f5fc72f181eed9
ToppCell	PBMC-Control-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_2\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	GRK3 TKT VCAN CTSS	1.57e-04	195	62	4	050fc59b328391d6e3ce23051764a842dcbb3144
ToppCell	Adult-Immune-monocyte\|Adult / Lineage, Cell type, age group and donor	GRK2 GRK3 VCAN CTSS	1.60e-04	196	62	4	3ef193c5180de3137daf886492e74fc574bc9767
ToppCell	COVID-19_Mild-Classical_Monocyte-cMono_3\|Classical_Monocyte / Disease condition and Cell class	GRK2 GRK3 TKT VCAN	1.60e-04	196	62	4	15397ec27167bb2fb6fec120b68bf38fc71b2670
ToppCell	metastatic_Brain-Myeloid_cells-Monocytes\|Myeloid_cells / Location, Cell class and cell subclass	TKT VCAN RPS24 CTSS	1.60e-04	196	62	4	d1a2768a1d0e5928fbd9debb7dcd7436134e09f6
Drug	betaARKct	GRK2 GRK3 VCAN	3.82e-07	6	62	3	CID000002295
Drug	Iproniazide phosphate [305-33-9]; Up 200; 14.4uM; MCF7; HT_HG-U133A	GRK2 GPT PLG ASIC3 PTGER3 KLHL18 KLHL22	1.11e-06	198	62	7	2288_UP
Drug	ethanol	PIKFYVE CERK GRK2 GRK3 TKT GPT PKN2 RELA LTF ASIC3 POLQ PTGER3	2.24e-06	837	62	12	CID000000702
Drug	sodium chloride	PIKFYVE TKFC GALK2 GRK2 GRK3 TKT VCAN PGM2L1 PKN2 RELA LTF PGM5	3.15e-06	865	62	12	CID000000206
Drug	fasudil	PIKFYVE GRK2 GRK3 PKN1 PTGER3 CIT	3.49e-06	151	62	6	CID000003547
Drug	ceramide 1-phosphate	CERK RELA	7.30e-06	2	62	2	ctd:C065576
Drug	Ro 16-6532	TKT LPA RELA LTF	1.05e-05	50	62	4	CID000122787
Drug	virus Tat	LPA GAN PLG	1.27e-05	17	62	3	CID000071655
Drug	Eserine sulfate, physostigmine sulfate [64-47-1]; Down 200; 6.2uM; PC3; HT_HG-U133A	GALK2 GRK2 GRK3 NAV3 CDADC1 BBS9	1.55e-05	196	62	6	5749_DN
Drug	Thioperamide maleate [106243-16-7]; Up 200; 9.8uM; MCF7; HT_HG-U133A	NDUFAF5 MORN1 GREB1 PTGER3 CTSS KLHL22	1.74e-05	200	62	6	5270_UP
Drug	8-thiomethyl-cAMP	GRK2 GRK3 LPA	1.81e-05	19	62	3	CID000093140
Drug	chloride	STK36 JPH4 GALK2 GRK2 GRK3 GPT RELA HAGH LTF PLG PTGER3 CLEC2B	1.82e-05	1029	62	12	CID000000312
Drug	AC1Q6RZ4	GALK2 GRK2 GRK3 TKT PGM2L1	2.14e-05	123	62	5	CID000000719
Drug	Aminocaproic Acid	LPA PLG	2.18e-05	3	62	2	DB00513
Drug	glucose-6-P	TKFC JPH4 GRK2 GRK3 TKT VCAN PGM2L1	6.03e-05	366	62	7	CID000000208
Drug	gallium	MELTF GAN LTF CIT	6.75e-05	80	62	4	CID000105145
Drug	methylglyoxal	TKFC TKT RELA HAGH PGM5	6.89e-05	157	62	5	CID000000880
Drug	C 5319	VCAN PGM2L1	7.26e-05	5	62	2	CID000054040
Drug	Furazolidone-d4	STK36 TKT RORC	7.41e-05	30	62	3	CID000003435
Drug	AC1Q4UMG	PKN1 RELA CIT	7.41e-05	30	62	3	CID000093587
Drug	arabinopyranose	GALK2 TKT VCAN PGM2L1 PKN2 LTF	7.69e-05	261	62	6	CID000000229
Drug	mannose-1-phosphate	GALK2 VCAN GPT PGM2L1 PGM5	8.72e-05	165	62	5	CID000000466
Drug	uranyl nitrate	LPA CIT RHOF	9.01e-05	32	62	3	CID000024933
Drug	K 252	GRK2 GRK3 PKN1 PKN2	9.79e-05	88	62	4	CID000003813
Drug	N6-monobutyryl-cAMP	GRK2 GRK3 LPA	9.90e-05	33	62	3	CID000115029
Drug	AC1OAGFB	PIKFYVE CERK GRK2 GRK3 PKN1 PKN2 RELA ASIC3	1.03e-04	539	62	8	CID006857345
Drug	nojirimycin 6-phosphate	VCAN PGM2L1	1.09e-04	6	62	2	CID000195171
Drug	BiM4	PIKFYVE GRK2 GRK3 PKN1 PKN2 RELA	1.20e-04	283	62	6	CID000002399
Drug	paeony root	GRK2 GAN RELA	1.29e-04	36	62	3	CID000073358
Drug	AC1L19WH	GALK2 RELA RHOF	1.40e-04	37	62	3	CID000000733
Drug	AC1Q566Y	GALK2 LPA	1.52e-04	7	62	2	CID000107148
Drug	Gantrez	STK36 GAN	1.52e-04	7	62	2	CID000062708
Drug	AC1MU1S9	PIKFYVE RAG2 GRK2 GRK3 LPA PKN2 RELA PTGER3	1.55e-04	572	62	8	CID000003733
Drug	CP-690334-01 [459212-38-5]; Up 200; 10uM; PC3; HT_HG-U133A	RAG2 MELTF RDH16 MORN1 KLHL22	1.61e-04	188	62	5	3823_UP
Drug	calphostin C	PIKFYVE GRK2 GRK3 PKN1 PKN2 RELA PTGER3	1.66e-04	431	62	7	CID000002533
Drug	Go6976	PIKFYVE GRK2 GRK3 PKN2 RELA	1.69e-04	190	62	5	CID000003501
Drug	Rapamycin; Up 200; 0.1uM; MCF7; HT_HG-U133A	VCAN GPT RORC GREB1 PTGER3	1.69e-04	190	62	5	5602_UP
Drug	Thiamphenicol [15318-45-3]; Down 200; 11.2uM; MCF7; HT_HG-U133A	GRK2 TNRC6B PKN1 RELA KLHL22	1.82e-04	193	62	5	7033_DN
Drug	AC1OAGKW	PIKFYVE RAG2 GRK2 GRK3 PKN2	1.82e-04	193	62	5	CID006857413
Drug	Salsolinol hydrobromide [38221-21-5]; Down 200; 15.4uM; PC3; HT_HG-U133A	GRK2 VCAN BBS9 CLEC2B KLHL22	1.86e-04	194	62	5	4232_DN
Drug	Norgestrel-(-)-D [797-63-7]; Up 200; 12.8uM; PC3; HT_HG-U133A	RDH16 VCAN NEK9 CTSS KLHL4	1.86e-04	194	62	5	4269_UP
Drug	Zomepirac sodium salt [64092-48-4]; Up 200; 12.8uM; PC3; HT_HG-U133A	NDUFAF5 LPA PLG PTGER3 NEK9	1.95e-04	196	62	5	4479_UP
Drug	Tinidazole [19387-91-8]; Down 200; 16.2uM; PC3; HT_HG-U133A	GRK3 USP24 BBS9 CLEC2B KLHL22	1.95e-04	196	62	5	4548_DN
Drug	Flunarizine dihydrochloride [30484-77-6]; Up 200; 8.4uM; PC3; HT_HG-U133A	GALK2 GRK2 USP24 TNRC6B CLEC2B	1.95e-04	196	62	5	7252_UP
Drug	Y-27632	PIKFYVE GRK2 PKN1 PKN2 PTGER3 CIT RHOF	2.00e-04	444	62	7	CID000005711
Drug	Clonidine hydrochloride [4205-91-8]; Up 200; 15uM; PC3; HT_HG-U133A	MELTF VCAN PTGER3 KLHL22 KLHL4	2.00e-04	197	62	5	4478_UP
Drug	Phenethicillin potassium salt [132-93-4]; Down 200; 10uM; MCF7; HT_HG-U133A	NDUFAF5 SGSH GREB1 NEK9 KLHL22	2.00e-04	197	62	5	6105_DN
Drug	Hydroflumethiazide [135-09-1]; Down 200; 12uM; MCF7; HT_HG-U133A	CERK GALK2 TNRC6B GAN LTBP1	2.00e-04	197	62	5	7019_DN
Drug	Chlormezanone [80-77-3]; Up 200; 14.6uM; PC3; HT_HG-U133A	GRK2 LPA VCAN BBS9 KLHL22	2.00e-04	197	62	5	4636_UP
Drug	Piperacetazine [3819-00-9]; Up 200; 9.8uM; HL60; HT_HG-U133A	SCRN3 LTBP1 PTGER3 NEK9 KLHL22	2.00e-04	197	62	5	6152_UP
Drug	Captopril [62571-86-2]; Up 200; 17.2uM; PC3; HT_HG-U133A	GAN ASIC3 PTGER3 BBS9 CLEC2B	2.00e-04	197	62	5	4585_UP
Drug	Me-3-Gpmp	RAG2 LTF	2.02e-04	8	62	2	CID000130442
Drug	102341-28-6	LPA CIT	2.02e-04	8	62	2	CID009941977
Drug	AC1O6FEQ	TKT CIT	2.02e-04	8	62	2	CID006474646
Drug	nsc25485	PIKFYVE LPA PKN2 RELA ASIC3 CLEC2B	2.04e-04	312	62	6	CID000004605
Drug	Phenformin hydrochloride [834-28-6]; Up 200; 16.6uM; MCF7; HT_HG-U133A	NDUFAF5 VCAN RORC CLEC2B KLHL22	2.05e-04	198	62	5	2312_UP
Drug	vinblastine sulfate; Down 200; 0.1uM; MCF7; HT_HG-U133A	GRK2 GRK3 VCAN USP24 BBS9	2.05e-04	198	62	5	7517_DN
Drug	Harmane hydrochloride [21655-84-5]; Up 200; 18.2uM; PC3; HT_HG-U133A	MELTF VCAN RELA PTGER3 NEK9	2.05e-04	198	62	5	4584_UP
Drug	Ampicillin trihydrate [7177-48-2]; Down 200; 10uM; PC3; HT_HG-U133A	SCRN3 GRK2 CDADC1 TNRC6B NUDT13	2.05e-04	198	62	5	6307_DN
Drug	magnesium	RAG2 CERK TKFC GALK2 GRK2 GRK3 TKT VCAN PGM2L1 PKN1 PKN2 NUDT13	2.06e-04	1325	62	12	CID000000888
Drug	Propranolol hydrochloride [318-98-9]; Down 200; 13.6uM; PC3; HT_HG-U133A	RAG2 GRK2 VCAN NUDT13 NEK9	2.10e-04	199	62	5	6759_DN
Drug	Rolitetracycline [751-97-3]; Up 200; 7.6uM; PC3; HT_HG-U133A	VCAN CDADC1 ASIC3 NEK9 CTSS	2.10e-04	199	62	5	6731_UP
Drug	Diflunisal [22494-42-4]; Down 200; 16uM; PC3; HT_HG-U133A	GALK2 VCAN PTGER3 BBS9 KLHL22	2.10e-04	199	62	5	4210_DN
Drug	ICI182,780; Up 200; 1uM; PC3; HT_HG-U133A	GALK2 GRK3 ASIC3 NUDT13 CLEC2B	2.10e-04	199	62	5	5931_UP
Drug	Epiandrosterone [481-29-8]; Up 200; 13.8uM; MCF7; HT_HG-U133A	GRK2 RORC ASIC3 PTGER3 BBS9	2.10e-04	199	62	5	3306_UP
Drug	Oxytetracycline dihydrate [6153-64-6]; Down 200; 8uM; PC3; HT_HG-U133A	VCAN NAV3 GAN CLEC2B KLHL22	2.14e-04	200	62	5	5772_DN
Drug	lactate	SCRN3 TKFC TKT GPT HAGH ASIC3 CIT	2.51e-04	461	62	7	CID000000612
Drug	AH6809	GRK2 GRK3 PTGER3	2.51e-04	45	62	3	CID000119461
Drug	Diketopiperazines	GPT RELA	2.59e-04	9	62	2	ctd:D054659
Drug	carisoprodol	RELA RHOF	2.59e-04	9	62	2	CID000002576
Drug	SCT-1	GRK2 GRK3	2.59e-04	9	62	2	CID000211458
Drug	bifendate	GPT RELA	2.59e-04	9	62	2	ctd:C465548
Drug	AC1MSB9O	VCAN PGM2L1	2.59e-04	9	62	2	CID003531598
Drug	zinc citrate	GAN LTF	2.59e-04	9	62	2	CID000011023
Drug	diclofenac	TKFC USP24 LTF ASIC3 PTGER3	2.63e-04	209	62	5	CID000003032
Drug	3-phosphoglycerate	TKT VCAN PGM2L1 PLG	2.66e-04	114	62	4	CID000000724
Drug	NPC 15437	GRK2 GRK3 PKN2	2.69e-04	46	62	3	CID000004548
Disease	chronic kidney disease, APOL1 risk genotype carrier status	LPA PLG	4.33e-05	5	62	2	EFO_0003884, EFO_0009324
Disease	plasma plasminogen measurement	LPA PLG	4.33e-05	5	62	2	EFO_0006309
Disease	angiostatin measurement	LPA PLG	6.48e-05	6	62	2	EFO_0008024
Disease	lipoprotein A measurement, apolipoprotein A 1 measurement	LPA PLG	9.06e-05	7	62	2	EFO_0004614, EFO_0006925
Disease	Liver Cirrhosis, Experimental	CERK TKFC GPT RELA LTBP1 HAGH PLG CTSS	2.09e-04	774	62	8	C0023893
Disease	Ulcerative Colitis	MST1 RELA LTF	3.21e-04	63	62	3	C0009324
Disease	fatty acid measurement, linoleic acid measurement	MORN1 LPA PLG	4.02e-04	68	62	3	EFO_0005110, EFO_0006807
Disease	amino acid measurement	RNF220 SCRN3 VCAN NAV3 GAN PKN1 LTBP1	5.39e-04	678	62	7	EFO_0005134
Disease	respiratory symptom change measurement, response to placebo	PKN2 BBS9	5.79e-04	17	62	2	EFO_0008344, EFO_0010068
Disease	Hypertensive disease	GRK2 RELA LTF PLG	6.94e-04	190	62	4	C0020538
Disease	renovascular hypertension (biomarker_via_orthology)	RELA PTGER3	7.26e-04	19	62	2	DOID:1591 (biomarker_via_orthology)
Disease	coronary artery disease	FNDC1 GRK3 MORN1 LPA PKN2 PLG NEK9 RHOF CTSS	8.31e-04	1194	62	9	EFO_0001645
Disease	Deep Vein Thrombosis	LPA PLG	8.89e-04	21	62	2	C0149871
Disease	Venous Thrombosis	LPA PLG	8.89e-04	21	62	2	C0042487
Disease	sleep duration, low density lipoprotein cholesterol measurement	LPA USP24 PLG	9.41e-04	91	62	3	EFO_0004611, EFO_0005271
Disease	female reproductive system disease	TNRC6B GREB1	1.07e-03	23	62	2	EFO_0009549
Disease	inflammatory bowel disease (implicated_via_orthology)	MST1 MST1L	1.26e-03	25	62	2	DOID:0050589 (implicated_via_orthology)
Disease	lipoprotein A measurement	FNDC1 LPA PLG	1.71e-03	112	62	3	EFO_0006925
Disease	Parkinson's disease (biomarker_via_orthology)	GRK2 GRK3	1.82e-03	30	62	2	DOID:14330 (biomarker_via_orthology)
Disease	Uterine leiomyoma, breast carcinoma	TNRC6B GREB1	2.07e-03	32	62	2	EFO_0000305, HP_0000131

Protein segments in the cluster

Peptide	Gene	Start	Entry
STSKGYMGECGFRGG	GPT	311	P24298
GFGEVYGCRKADTGK	GRK3	201	P35626
RGEGGSCYHFAMSGK	ATP13A5	786	Q4VNC0
GCYGDKMGKAGVRTY	VCAN	216	P13611
AEGKSRSCDGTGAMY	CDADC1	346	Q9BWV3
VMNGDGKGTYGLDCD	CIT	271	O14578
GFGEVYGCRKADTGK	GRK2	201	P25098
YSRGKSMGVLFGGRS	RAG2	146	P55895
TLLEAMKGGEYGFGA	PGM5	276	Q15124
GGCYEGEVSHGMREG	MORN1	106	Q5T089
SVFKEYAGSMGESCG	LY6K	131	Q17RY6
GSDYYGCMGVDKVAG	NEK9	451	Q8TD19
GGGNRAKYESAGMSC	GREB1	331	Q4ZG55
VSCFRGKGEGYRGTA	MST1L	251	Q2TV78
VAGCGKFYEGTADEM	HAGH	186	Q16775
MSPGGKFDFDDGGCY	JPH4	1	Q96JJ6
MTGGRFDFDDGGTYC	JPH1	1	Q9HDC5
GTAAFKEICPGGMGY	LTBP1	721	Q14766
GLRSAMGAGFCYIND	PGM2L1	71	Q6PCE3
MKETRGYGGDAPFCT	PTGER3	1	P43115
DVGGYMSDGDILGKS	NAV3	816	Q8IVL0
YTTKMKGRLCGDGTG	FAM169B	56	Q8N8A8
AKSERYIGTEGGGMD	GALK2	176	Q01415
TRMGKCYTFNSGADG	ASIC3	181	Q9UHC3
RDMCGAKTGKYSLGD	LHFPL4	156	Q7Z7J7
PKGMYSALAGFCDIG	NUDT13	221	Q86X67
GGRDGSSCLKSMEYF	KLHL4	576	Q9C0H6
CNMTYGSFGGVKGRD	BBS9	136	Q3SYG4
IPGKFMGYTGDLRAC	PIKFYVE	196	Q9Y2I7
GAASLGSKMFVCGGY	KLHL18	471	O94889
GSKMFVCGGYDGSGF	KLHL18	476	O94889
SCDYFRGMFAGGLKE	KLHL22	71	Q53GT1
DKYDGIVCVGGDGMF	CERK	186	Q8TCT0
SRGFLLGYGESGRKM	FNDC1	191	Q4ZHG4
MGGGSYGKLFESVEC	GAN	426	Q9H2C0
CYGIIYGMGAKSLGE	POLQ	2386	O75417
SEQDCMFGNGKGYRG	LPA	1716	P08519
NSLEGMKGGYKGTCA	DTHD1	271	Q6ZMT9
STEKYGNKGCNGGFM	CTSS	171	P25774
VSCFRGKGEGYRGTA	MST1	281	P26927
DKSGAGCGPFYLMRE	MED19	56	A0JLT2
GDGGCGKTSLLMVYS	RHOF	26	Q9HBH0
MSLDGGYVYTAGKCG	LTF	411	P02788
MGCDVLKAVSDYFGG	MELTF	156	P08582
CRYFTDGKGVVGGVM	NCOA7	226	Q8NI08
MGRVSLFGGGYCISK	RDH16	166	O75452
KYGQGGNCTEGRMVF	SCRN3	136	Q0VDG4
IADFGLCKEGMGYGD	PKN1	756	Q16512
LCKEGMGYGDRTSTF	PKN1	761	Q16512
EGGFRGSGFIMCSGK	RNF220	371	Q5VTB9
FGLCKEGMGYGDRTS	PKN2	801	Q16513
GAMFGGDTLYELRCS	NDUFAF5	186	Q5TEU4
PSEEDCMFGNGKGYR	PLG	476	P00747
CMFGNGKGYRGKRAT	PLG	481	P00747
GTFCEKFGNGESGMG	SGSH	191	P51688
GGGIKLCDFGFARAM	STK36	136	Q9NRP7
FTKSFGMRGSEGCAY	CLEC2B	111	Q92478
GMRGSEGCAYLSDDG	CLEC2B	116	Q92478
KYGGMELFRALGCSE	RORC	381	P51449
GQGLGAACGMAYTGK	TKT	126	P29401
GGKTTGFGMIYDSLD	RPS24	66	P62847
MESGAYGAAKAGGSF	SYNGR2	1	O43760
AGICSYEGKGGMCSI	SPRTN	76	Q9H040
SGFVGLRNGGATCYM	USP24	1686	Q9UPU5
EKMGGSSGALYGLFL	TKFC	441	Q3LXA3
GMRFRYKCEGRSAGS	RELA	31	Q04206
DYGMVGGKEAGTESR	TNRC6B	1381	Q9UPQ9