Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	hedgehog receptor activity	PTCH1 PTCH2	7.73e-05	3	102	2	GO:0008158
GeneOntologyMolecularFunction	smoothened binding	PTCH1 PTCH2	1.54e-04	4	102	2	GO:0005119
GeneOntologyMolecularFunction	hedgehog family protein binding	PTCH1 PTCH2	1.54e-04	4	102	2	GO:0097108
GeneOntologyMolecularFunction	olfactory receptor activity	OR4C45 OR11H6 OR12D3 OR4C15 OR4A8 OR11A1 OR4A5 OR4B1 OR2AE1	3.64e-04	431	102	9	GO:0004984
Domain	ARM-type_fold	DCAF1 TNPO2 VEPH1 VIRMA PPP2R5B IPO9 IQCB1 EIF2B5 STAG2 EIF3M	1.39e-05	339	100	10	IPR016024
Domain	TM_rcpt_patched	PTCH1 PTCH2	2.84e-05	2	100	2	IPR004766
Domain	ATII_rcpt	GPR25 CXCR5	2.81e-04	5	100	2	IPR000248
Domain	P-loop_NTPase	TANC2 MYH3 ABCA1 ABCA13 DNAH14 NLRC4 MFN1 GTPBP2 TRANK1 ABCC8 IQCB1 HYDIN AQR	5.85e-04	848	100	13	IPR027417
Domain	Ptc/Disp	PTCH1 PTCH2	9.97e-04	9	100	2	IPR003392
Domain	Patched	PTCH1 PTCH2	9.97e-04	9	100	2	PF02460
Domain	ABC_A	ABCA1 ABCA13	1.81e-03	12	100	2	IPR026082
Domain	SSD	PTCH1 PTCH2	2.13e-03	13	100	2	IPR000731
Domain	SSD	PTCH1 PTCH2	2.13e-03	13	100	2	PS50156
Domain	ABC_tran	ABCA1 ABCA13 ABCC8	2.16e-03	48	100	3	PF00005
Domain	ABC_TRANSPORTER_2	ABCA1 ABCA13 ABCC8	2.16e-03	48	100	3	PS50893
Domain	ABC_TRANSPORTER_1	ABCA1 ABCA13 ABCC8	2.30e-03	49	100	3	PS00211
Domain	ABC_transporter-like	ABCA1 ABCA13 ABCC8	2.43e-03	50	100	3	IPR003439
Domain	IMPORTIN_B_NT	TNPO2 IPO9	2.48e-03	14	100	2	PS50166
Domain	IBN_N	TNPO2 IPO9	2.85e-03	15	100	2	PF03810
Domain	IBN_N	TNPO2 IPO9	3.24e-03	16	100	2	SM00913
Domain	PCI_dom	EIF3M PCID2	3.66e-03	17	100	2	IPR000717
Domain	PCI	EIF3M PCID2	3.66e-03	17	100	2	PF01399
Domain	Importin-beta_N	TNPO2 IPO9	3.66e-03	17	100	2	IPR001494
Domain	Olfact_rcpt	OR11H6 OR12D3 OR4C15 OR11A1 OR4A5 OR4B1 OR2AE1	5.19e-03	393	100	7	IPR000725
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR4C45 OR11H6 OR12D3 OR4C15 OR4A8 OR11A1 OR4A5 OR4B1	8.16e-06	340	103	8	11875048
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR4C45 OR11H6 OR12D3 OR4C15 OR4A8 OR11A1 OR4A5 OR4B1	8.16e-06	340	103	8	11802173
Pubmed	ATP binding cassette family A protein 1 determines hexosylceramide and sphingomyelin levels in human and mouse plasma.	ABCA1 MTTP	8.69e-06	2	103	2	30279221
Pubmed	Ptch2 loss drives myeloproliferation and myeloproliferative neoplasm progression.	PTCH1 PTCH2	8.69e-06	2	103	2	26834157
Pubmed	HIF-1beta determines ABCA1 expression under hypoxia in human macrophages.	ABCA1 ARNT	8.69e-06	2	103	2	19828131
Pubmed	Lipid absorption defects in intestine-specific microsomal triglyceride transfer protein and ATP-binding cassette transporter A1-deficient mice.	ABCA1 MTTP	8.69e-06	2	103	2	24019513
Pubmed	The protein-specific activities of the transmembrane modules of Ptch1 and Ptch2 are determined by their adjacent protein domains.	PTCH1 PTCH2	8.69e-06	2	103	2	30166346
Pubmed	Nephronophthisis: disease mechanisms of a ciliopathy.	NPHP4 IQCB1	8.69e-06	2	103	2	19118152
Pubmed	Inherited rare and common variants in PTCH1 and PTCH2 contributing to the predisposition to reproductive cancers.	PTCH1 PTCH2	8.69e-06	2	103	2	34990798
Pubmed	[Studies on keratocystic odontogenic tumors].	PTCH1 PTCH2	8.69e-06	2	103	2	19221557
Pubmed	Update of genetic variants in CEP120 and CC2D2A-With an emphasis on genotype-phenotype correlations, tissue specific transcripts and exploring mutation specific exon skipping therapies.	CEP120 CC2D2A	8.69e-06	2	103	2	33486889
Pubmed	Congenital embryonal rhabdomyosarcoma caused by heterozygous concomitant PTCH1 and PTCH2 germline mutations.	PTCH1 PTCH2	8.69e-06	2	103	2	29230040
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR4C45 OR11H6 OR12D3 OR4C15 OR4A8 OR11A1 OR4A5 OR4B1	8.69e-06	343	103	8	32295537
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR4C45 OR11H6 OR12D3 OR4C15 OR4A8 OR11A1 OR4A5 OR4B1	9.26e-06	346	103	8	14611657
Pubmed	Mutation analysis of 18 nephronophthisis associated ciliopathy disease genes using a DNA pooling and next generation sequencing strategy.	NPHP4 IQCB1 CC2D2A	1.99e-05	18	103	3	21068128
Pubmed	Ptch2 mediates the Shh response in Ptch1-/- cells.	PTCH1 PTCH2	2.60e-05	3	103	2	25085974
Pubmed	The gene mutated in juvenile nephronophthisis type 4 encodes a novel protein that interacts with nephrocystin.	NPHP4 IQCB1	2.60e-05	3	103	2	12244321
Pubmed	Intestine-specific MTP and global ACAT2 deficiency lowers acute cholesterol absorption with chylomicrons and HDLs.	ABCA1 MTTP	2.60e-05	3	103	2	25030663
Pubmed	Role of plasma and liver cholesterol- and lipoprotein-metabolism determinants in LpX formation in the mouse.	ABCA1 MTTP	2.60e-05	3	103	2	17399905
Pubmed	SPTLC1 binds ABCA1 to negatively regulate trafficking and cholesterol efflux activity of the transporter.	ABCA1 SPTLC1	2.60e-05	3	103	2	18484747
Pubmed	SENIOR-LØKEN SYNDROME: A Case Series and Review of the Renoretinal Phenotype and Advances of Molecular Diagnosis.	NPHP4 IQCB1	2.60e-05	3	103	2	33512896
Pubmed	Vascular Disease Is Associated With the Expression of Genes for Intestinal Cholesterol Transport and Metabolism.	ABCA1 MTTP	2.60e-05	3	103	2	27841945
Pubmed	Functionally Distinctive Ptch Receptors Establish Multimodal Hedgehog Signaling in the Tooth Epithelial Stem Cell Niche.	PTCH1 PTCH2	2.60e-05	3	103	2	31145830
Pubmed	Mechanism of inhibition of the tumor suppressor Patched by Sonic Hedgehog.	PTCH1 PTCH2	2.60e-05	3	103	2	27647915
Pubmed	Ptch2, a second mouse Patched gene is co-expressed with Sonic hedgehog.	PTCH1 PTCH2	2.60e-05	3	103	2	9462734
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	DCAF1 ATP9A FHIP2A VIRMA ADCY2 PLEKHM2 MACF1 AQR	2.96e-05	407	103	8	12693553
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	DCAF1 UBR1 WDR46 NAP1L1 ZC3H7A IPO9 OXCT1 VPS33B EIF2B5 BYSL MACF1 EIF3M PCID2 AQR	4.62e-05	1353	103	14	29467282
Pubmed	KAP1 facilitates reinstatement of heterochromatin after DNA replication.	WDR46 SPTLC1 NELFB NAP1L1 VIRMA FANCD2 OXCT1 VPS33B KDELR1 PCYT2	4.71e-05	704	103	10	29955894
Pubmed	Characterization of the nephrocystin/nephrocystin-4 complex and subcellular localization of nephrocystin-4 to primary cilia and centrosomes.	NPHP4 IQCB1	5.19e-05	4	103	2	15661758
Pubmed	[Exploring parent-of-origin effects for non-syndromic cleft lip with or without cleft palate on PTCH1, PTCH2, SHH, SMO genes in Chinese case-parent trios].	PTCH1 PTCH2	5.19e-05	4	103	2	33047712
Pubmed	Disruption of the phosphatidylserine decarboxylase gene in mice causes embryonic lethality and mitochondrial defects.	ABCA1 PCYT2	5.19e-05	4	103	2	16192276
Pubmed	Fibroblast growth factor 10 is required for proper development of the mouse whiskers.	PTCH1 PTCH2	5.19e-05	4	103	2	12615071
Pubmed	Overlapping and non-overlapping Ptch2 expression with Shh during mouse embryogenesis.	PTCH1 PTCH2	5.19e-05	4	103	2	9858693
Pubmed	Cilia gene mutations cause atrioventricular septal defects by multiple mechanisms.	IFT140 PTCH1 CC2D2A	5.53e-05	25	103	3	27340223
Pubmed	Mouse Models of Inherited Retinal Degeneration with Photoreceptor Cell Loss.	CLN8 NPHP4 CXCR5 IQCB1 CC2D2A MACF1	7.05e-05	233	103	6	32290105
Pubmed	Odorant and vomeronasal receptor genes in two mouse genome assemblies.	OR4C15 OR4A8 OR4A5 OR4B1	7.12e-05	74	103	4	15081110
Pubmed	Patched1 and Patched2 inhibit Smoothened non-cell autonomously.	PTCH1 PTCH2	8.64e-05	5	103	2	27552050
Pubmed	Expression of Sonic Hedgehog and pathway components in the embryonic mouse head: anatomical relationships between regulators of positive and negative feedback.	PTCH1 PTCH2	8.64e-05	5	103	2	34353359
Pubmed	Adaptive immune defects against glycoantigens in chronic granulomatous disease via dysregulated nitric oxide production.	CYBB CDH23	8.64e-05	5	103	2	21630251
Pubmed	Suppression of hair follicle development inhibits induction of sonic hedgehog, patched, and patched-2 in hair germs in mice.	PTCH1 PTCH2	8.64e-05	5	103	2	11758785
Pubmed	Hedgehog and patched gene expression in adult ocular tissues.	PTCH1 PTCH2	8.64e-05	5	103	2	9237688
Pubmed	22q11 Gene dosage establishes an adaptive range for sonic hedgehog and retinoic acid signaling during early development.	PTCH1 PTCH2 ALDH1A3	8.72e-05	29	103	3	23077214
Pubmed	BMP4-BMPR1A signaling in beta cells is required for and augments glucose-stimulated insulin secretion.	CAPN10 ARNT ABCC8	8.72e-05	29	103	3	17339028
Pubmed	Embryonic forebrain transcriptome of mice with polyalanine expansion mutations in the ARX homeobox gene.	ESRP1 PTCH1 CXCR5	1.07e-04	31	103	3	27798109
Pubmed	Systematic Affinity Purification Coupled to Mass Spectrometry Identified p62 as Part of the Cannabinoid Receptor CB2 Interactome.	UBR1 B4GAT1 SPTLC1 FANCD2	1.17e-04	84	103	4	31616248
Pubmed	Multipotent CD15+ cancer stem cells in patched-1-deficient mouse medulloblastoma.	PTCH1 PTCH2	1.29e-04	6	103	2	19487286
Pubmed	Metabolic control of TFH cells and humoral immunity by phosphatidylethanolamine.	CXCR5 PCYT2	1.29e-04	6	103	2	34234346
Pubmed	Ciliopathy-associated protein CEP290 modifies the severity of retinal degeneration due to loss of RPGR.	NPHP4 IQCB1	1.29e-04	6	103	2	26936822
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	RHBDF1 NAP1L1 ATP9A VIRMA ZC3H7A WDR20 KDELR1 BYSL MACF1 STAG2 EIF3M NR1I3 PCID2 AQR	1.35e-04	1497	103	14	31527615
Pubmed	Characterization of two patched receptors for the vertebrate hedgehog protein family.	PTCH1 PTCH2	1.81e-04	7	103	2	9811851
Pubmed	Sex-specific proteome differences in the anterior cingulate cortex of schizophrenia.	CRYAB OXCT1 FTL	2.30e-04	40	103	3	20381070
Pubmed	Malarial hemozoin is a Nalp3 inflammasome activating danger signal.	CYBB NLRC4	2.40e-04	8	103	2	19652710
Pubmed	Genome-wide association study reveals two new risk loci for bipolar disorder.	ADCY2 TRANK1	2.40e-04	8	103	2	24618891
Pubmed	Patched Receptors Sense, Interpret, and Establish an Epidermal Hedgehog Signaling Gradient.	PTCH1 PTCH2	2.40e-04	8	103	2	27498049
Pubmed	Complementary expression patterns of retinoid acid-synthesizing and -metabolizing enzymes in pre-natal mouse inner ear structures.	DCT ALDH1A3	2.40e-04	8	103	2	15161092
Pubmed	A distinct Smoothened mutation causes severe cerebellar developmental defects and medulloblastoma in a novel transgenic mouse model.	PTCH1 PTCH2	2.40e-04	8	103	2	22869526
Pubmed	Defects in mouse mammary gland development caused by conditional haploinsufficiency of Patched-1.	PTCH1 PTCH2	2.40e-04	8	103	2	10529434
Pubmed	Conserved Genetic Interactions between Ciliopathy Complexes Cooperatively Support Ciliogenesis and Ciliary Signaling.	NPHP4 CC2D2A	2.40e-04	8	103	2	26540106
Pubmed	Endogenous β-glucocerebrosidase activity in Abca12⁻/⁻epidermis elevates ceramide levels after topical lipid application but does not restore barrier function.	ABCA1 SPTLC1	2.40e-04	8	103	2	24293640
Pubmed	Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog.	PTCH1 PTCH2	2.40e-04	8	103	2	10027293
Pubmed	A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.	TNPO2 NELFB IPO9 CEP120 VPS33B EIF2B5 PCID2 AQR	2.68e-04	560	103	8	35241646
Pubmed	Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways.	NAP1L1 NPHP4 CRYAB IPO9 OXCT1 IQCB1 CC2D2A ALDH1A3	2.81e-04	564	103	8	21565611
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	WDR46 SPTLC1 NAP1L1 IDE FANCD2 IPO9 VPS33B EIF2B5 BYSL CC2D2A STAG2 EIF3M AQR	3.02e-04	1425	103	13	30948266
Pubmed	A sonic hedgehog signaling domain in the arterial adventitia supports resident Sca1+ smooth muscle progenitor cells.	PTCH1 PTCH2	3.08e-04	9	103	2	18591670
Pubmed	Apolipoprotein specificity for lipid efflux by the human ABCAI transporter.	ABCA1 ABCA13	3.08e-04	9	103	2	11162594
Pubmed	Autonomous and non-autonomous Shh signalling mediate the in vivo growth and guidance of mouse retinal ganglion cell axons.	PTCH1 PTCH2	3.08e-04	9	103	2	18832395
Pubmed	Targeted deletion of the AAA-ATPase Ruvbl1 in mice disrupts ciliary integrity and causes renal disease and hydrocephalus.	NPHP4 IQCB1	3.08e-04	9	103	2	29959317
Pubmed	The sonic hedgehog-patched-gli pathway in human development and disease.	PTCH1 PTCH2	3.08e-04	9	103	2	11001584
Pubmed	Patched2 modulates tumorigenesis in patched1 heterozygous mice.	PTCH1 PTCH2	3.08e-04	9	103	2	16849540
Pubmed	A spontaneous mouse mutation, mesenchymal dysplasia (mes), is caused by a deletion of the most C-terminal cytoplasmic domain of patched (ptc).	PTCH1 PTCH2	3.08e-04	9	103	2	11784021
Pubmed	Human immunodeficiency virus type 1 Vpr links proteasomal degradation and checkpoint activation.	DCAF1 UBR1	3.08e-04	9	103	2	17855541
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	TANC2 STAB1 FANCD2 IPO9 VPS33B MACF1 STAG2 AQR	3.46e-04	582	103	8	20467437
Pubmed	Cleft lip and cleft palate in Esrp1 knockout mice is associated with alterations in epithelial-mesenchymal crosstalk.	ESRP1 MACF1 ALDH1A3	3.72e-04	47	103	3	32253237
Pubmed	The Shh signalling pathway in early tooth development.	PTCH1 PTCH2	3.85e-04	10	103	2	10512189
Pubmed	In situ hybridization methods for mouse whole mounts and tissue sections with and without additional β-galactosidase staining.	PTCH1 PTCH2	3.85e-04	10	103	2	24318810
Pubmed	Cholesterol Modification of Smoothened Is Required for Hedgehog Signaling.	PTCH1 PTCH2	3.85e-04	10	103	2	28344083
Pubmed	Indian hedgehog activates hematopoiesis and vasculogenesis and can respecify prospective neurectodermal cell fate in the mouse embryo.	PTCH1 PTCH2	3.85e-04	10	103	2	11311154
Pubmed	Evidence that preaxial polydactyly in the Doublefoot mutant is due to ectopic Indian Hedgehog signaling.	PTCH1 PTCH2	4.69e-04	11	103	2	9671585
Pubmed	Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation.	PTCH1 PTCH2	4.69e-04	11	103	2	10465785
Pubmed	Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterning.	PTCH1 PTCH2	4.69e-04	11	103	2	17442700
Pubmed	Runx2 (Cbfa1) inhibits Shh signaling in the lower but not upper molars of mouse embryos and prevents the budding of putative successional teeth.	PTCH1 PTCH2	4.69e-04	11	103	2	15668330
Pubmed	Complex transcription and splicing of odorant receptor genes.	OR12D3 OR11A1	4.69e-04	11	103	2	12637542
Pubmed	Congenital Hepatic Fibrosis Overview ─ RETIRED CHAPTER, FOR HISTORICAL REFERENCE ONLY	NPHP4 IQCB1 CC2D2A	5.02e-04	52	103	3	20301743
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	DCAF1 TANC2 IFT140 CDH23 NPHP4 IPO9 CEP120 WDR20 IQCB1 EIF2B5 DEPDC1B EIF3M	5.43e-04	1321	103	12	27173435
Pubmed	Genetically engineered mouse models of brain cancer and the promise of preclinical testing.	PTCH1 PTCH2	5.62e-04	12	103	2	19076778
Pubmed	Cholesterol modification of sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1.	PTCH1 PTCH2	5.62e-04	12	103	2	11389830
Pubmed	Macrophages monitor tissue osmolarity and induce inflammatory response through NLRP3 and NLRC4 inflammasome activation.	CYBB NLRC4	5.62e-04	12	103	2	25959047
Pubmed	Lhx2 is a progenitor-intrinsic modulator of Sonic Hedgehog signaling during early retinal neurogenesis.	PTCH1 PTCH2	5.62e-04	12	103	2	36459481
Pubmed	H19X-encoded miR-322(424)/miR-503 regulates muscle mass by targeting translation initiation factors.	EIF2B5 EIF3M	5.62e-04	12	103	2	34704401
Pubmed	Paracrine Hedgehog signaling in stomach and intestine: new roles for hedgehog in gastrointestinal patterning.	PTCH1 PTCH2	5.62e-04	12	103	2	19445942
Pubmed	Attenuated sensing of SHH by Ptch1 underlies evolution of bovine limbs.	PTCH1 PTCH2	5.62e-04	12	103	2	24990743
Pubmed	Hedgehog signaling regulates differentiation from double-negative to double-positive thymocyte.	PTCH1 PTCH2	5.62e-04	12	103	2	10981962
Pubmed	Vsx2/Chx10 ensures the correct timing and magnitude of Hedgehog signaling in the mouse retina.	PTCH1 PTCH2	5.62e-04	12	103	2	18417110
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	SZT2 SPTLC1 VIRMA FANCD2 ZC3H7A GTPBP2 ARNT IPO9 WDR20 PCYT2 FTL EIF3M	5.65e-04	1327	103	12	32694731
Pubmed	FGFR2 signaling enhances the SHH-BMP4 signaling axis in early ureter development.	PTCH1 FGF20 ALDH1A3	5.92e-04	55	103	3	35020897
Pubmed	Expression patterns of Hedgehog signalling pathway members during mouse palate development.	PTCH1 PTCH2	6.63e-04	13	103	2	16168717
Pubmed	Control of glial precursor cell development in the mouse optic nerve by sonic hedgehog from retinal ganglion cells.	PTCH1 PTCH2	6.63e-04	13	103	2	18625210
Pubmed	Contribution of 20 single nucleotide polymorphisms of 13 genes to dyslipidemia associated with antiretroviral therapy.	ABCA1 MTTP	6.63e-04	13	103	2	17700364
Pubmed	Transdifferentiation of the ventral retinal pigmented epithelium to neural retina in the growth arrest specific gene 1 mutant.	PTCH1 DCT	6.63e-04	13	103	2	11456441
Pubmed	Neutrophil elastase causes tissue damage that decreases host tolerance to lung infection with burkholderia species.	CYBB NLRC4	6.63e-04	13	103	2	25166912
Cytoband	Ensembl 112 genes in cytogenetic band chr11q11	OR4C15 OR4A8 OR4A5	1.02e-04	40	103	3	chr11q11
Cytoband	11p11.12	OR4C45 OR4A8 OR4A5	1.18e-04	42	103	3	11p11.12
Cytoband	Ensembl 112 genes in cytogenetic band chr1p34	SZT2 GJA9 PTCH2 MACF1 ZMYM6	5.46e-04	294	103	5	chr1p34
GeneFamily	Olfactory receptors, family 4	OR4C45 OR4C15 OR4A8 OR4A5 OR4B1	7.99e-05	129	62	5	151
GeneFamily	ATP binding cassette subfamily A	ABCA1 ABCA13	1.03e-03	14	62	2	805
GeneFamily	Armadillo repeat containing\|Importins	TNPO2 IPO9	1.71e-03	18	62	2	596
GeneFamily	Olfactory receptors, family 11	OR11H6 OR11A1	2.79e-03	23	62	2	159
Coexpression	GSE29615_CTRL_VS_DAY3_LAIV_IFLU_VACCINE_PBMC_DN	TNPO2 VEPH1 IDE IPO9 OXCT1 MACF1 AQR	1.01e-05	195	100	7	M4917
Coexpression	GSE2585_AIRE_KO_VS_WT_CD80_LOW_MTEC_UP	CYBB DCAF1 TANC2 SZT2 ESRP1 DCT VPS33B	1.08e-05	197	100	7	M6278
ToppCell	mild_COVID-19_(asymptomatic)-RBC\|World / disease group, cell group and cell class (v2)	VIRMA FANCD2 CXCR5 GPR180 SEC61A2 GEN1	2.72e-06	169	103	6	2bda6ab3f32e05cb7daf91eb7c39b4fcc9ae91bb
ToppCell	facs-Diaphragm-Limb_Muscle-24m\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA13 VEPH1 SPTLC1 TRANK1 FTL HYDIN	2.72e-06	169	103	6	12bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCell	facs-Marrow-T-cells-3m-Myeloid-granulocytopoietic_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA13 CDH23 FANCD2 ABCC8 PTCH2 DEPDC1B	2.91e-06	171	103	6	913bae728b5e653771a27c79a309eb023699f1d0
ToppCell	facs-Marrow-T-cells-3m-Myeloid-granulocytopoietic_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA13 CDH23 FANCD2 ABCC8 PTCH2 DEPDC1B	2.91e-06	171	103	6	f28b2336057e353b96a6ff4581ec9fd0ca0789d9
ToppCell	mild_COVID-19_(asymptomatic)-RBC\|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)	VIRMA FANCD2 GPR180 SEC61A2 PCYT2 GEN1	2.91e-06	171	103	6	78491478ba65bad45238fe114f5251b2adea323d
Disease	BASAL CELL CARCINOMA, SUSCEPTIBILITY TO, 1	PTCH1 PTCH2	6.52e-05	4	98	2	605462
Disease	Basal cell carcinoma, susceptibility to, 1	PTCH1 PTCH2	6.52e-05	4	98	2	cv:C2751544
Disease	Oculo-dento-digital syndrome	PTCH1 PTCH2	6.52e-05	4	98	2	C0812437
Disease	Disorder of eye	CLN8 CDH23 NPHP4 IQCB1 MTTP CC2D2A	7.78e-05	212	98	6	C0015397
Disease	Global developmental delay	SZT2 FHIP2A GTPBP2 PCYT2 STAG2	8.37e-05	133	98	5	C0557874
Disease	Basal Cell Nevus Syndrome	PTCH1 PTCH2	1.08e-04	5	98	2	C0004779
Disease	Intellectual Disability	TANC2 FHIP2A CAPN10 GTPBP2 PCYT2 MACF1 STAG2 ZMYM6	1.25e-04	447	98	8	C3714756
Disease	nephronophthisis (is_implicated_in)	NPHP4 IQCB1	1.62e-04	6	98	2	DOID:12712 (is_implicated_in)
Disease	Renal dysplasia and retinal aplasia	NPHP4 IQCB1	2.27e-04	7	98	2	cv:C0403553
Disease	Senior-Loken syndrome (is_implicated_in)	NPHP4 IQCB1	2.27e-04	7	98	2	DOID:0050576 (is_implicated_in)
Disease	semaphorin-3G measurement	SEMA3G MGAT3	3.02e-04	8	98	2	EFO_0802049
Disease	holoprosencephaly (is_implicated_in)	PTCH1 STAG2	3.02e-04	8	98	2	DOID:4621 (is_implicated_in)
Disease	Meckel syndrome (implicated_via_orthology)	NPHP4 CC2D2A	3.02e-04	8	98	2	DOID:0050778 (implicated_via_orthology)
Disease	Ciliopathies	CDH23 NPHP4 IQCB1 CC2D2A	5.04e-04	110	98	4	C4277690
Disease	Gastrointestinal Stromal Sarcoma	PTCH1 PTCH2 CC2D2A	5.18e-04	47	98	3	C3179349
Disease	Jeune thoracic dystrophy	IFT140 CEP120	5.89e-04	11	98	2	C0265275
Disease	Gastrointestinal Stromal Tumors	PTCH1 PTCH2 CC2D2A	6.22e-04	50	98	3	C0238198
Disease	Renal dysplasia and retinal aplasia (disorder)	NPHP4 IQCB1	7.05e-04	12	98	2	C0403553
Disease	hyperinsulinism (is_implicated_in)	ABCC8 MTTP	7.05e-04	12	98	2	DOID:2018 (is_implicated_in)
Disease	basal cell carcinoma (is_implicated_in)	PTCH1 PTCH2	7.05e-04	12	98	2	DOID:2513 (is_implicated_in)
Disease	Short Rib-Polydactyly Syndrome	IFT140 CEP120	8.32e-04	13	98	2	C0036996
Disease	Pneumoconiosis	CDH23 OVGP1	9.68e-04	14	98	2	C0032273
Disease	Bagassosis	CDH23 OVGP1	9.68e-04	14	98	2	C0004681
Disease	Saldino-Noonan Syndrome	IFT140 CEP120	9.68e-04	14	98	2	C0036069
Disease	Majewski Syndrome	IFT140 CEP120	9.68e-04	14	98	2	C0024507
Disease	response to methotrexate, neurotoxicity	DCT MACF1	1.80e-03	19	98	2	EFO_0011057, GO_0031427
Disease	familial hyperlipidemia (biomarker_via_orthology)	ABCA1 MTTP	1.80e-03	19	98	2	DOID:1168 (biomarker_via_orthology)
Disease	Arthrogryposis	MYH3 VPS33B	2.20e-03	21	98	2	C0003886
Disease	Manic	ADCY2 STAB1 TRANK1	2.26e-03	78	98	3	C0338831
Disease	Leber Congenital Amaurosis	IFT140 IQCB1	2.42e-03	22	98	2	C0339527
Disease	type 2 diabetes mellitus (is_implicated_in)	ABCA1 IDE CAPN10 ABCC8	2.58e-03	171	98	4	DOID:9352 (is_implicated_in)
Disease	phosphatidylcholine measurement	ABCA1 CEP120 ABCC8 MACF1 ZMYM6	2.61e-03	284	98	5	EFO_0010226
Disease	3-hydroxybutyrate measurement	ABCA1 OXCT1	3.12e-03	25	98	2	EFO_0010982

Protein segments in the cluster

Peptide	Gene	Start	Entry
LEDLEKHFFAFIDAL	URAD	41	A6NGE7
FEHFNGVAELLEILG	PPP2R5B	246	Q15173
HLILEAADGFLFIVS	ARNT	166	P27540
TETFLFHLAVADLLL	CXCR5	86	P32302
LHVAGFDFEVLNEGF	B4GAT1	356	O43505
FEAEIVLLFHATTFR	GTPBP2	506	Q9BX10
TFVLHLAAADLGFVL	GPR25	76	O00155
GAFVELFHEIDDRLS	ABCA1	1216	O95477
AITELLTGREHVEFF	ABCA1	1996	O95477
FLHAFFIDLEGCIRT	ALDH1A3	126	P47895
EAIITSLHEFGFLEQ	ABCA13	896	Q86UQ4
LLTFHLFDAFVSVLG	DEPDC1B	286	Q8WUY9
HFRVLFDITQEDVLF	AASDH	221	Q4L235
ARELGEFHAFIVSDL	CAPN10	231	Q9HC96
GEFSLHEQTVLLLFL	AQR	136	O60306
SFLFVDVIDDHERGL	DEDD	46	O75618
FEEEFIHLLSNITGA	CDH23	2971	Q9H251
ILDFLGEFATDIRTH	ESRP1	461	Q6NXG1
SRLFDQFFGEHLLES	CRYAB	21	P02511
AEAILAADFEIGHFL	NAP1L1	316	P55209
EEGLFVIHLRSNDIF	CDC42BPG	1111	Q6DT37
IFDQLLEFVTEGSHF	MFN1	21	Q8IWA4
VFEHVVFSVGRLLDL	ANO7	856	Q6IWH7
VGFQVEFLELLFHFH	NR1I3	236	Q14994
IILGVAEGEFFIHDA	DCAF1	661	Q9Y4B6
DIPELHFLFFIVFTA	OR11A1	21	Q9GZK7
FVTEFVLLGFHGQRE	OR11H6	26	Q8NGC7
FAEHFFAGVEVIVLT	OR4C15	101	Q8NGM1
EHVFLVESFDLIQEF	MATN4	191	O95460
AHEFIELIFGIALTD	MAGEC3	501	Q8TD91
LALEGVFSHKFDFEL	NLRC4	396	Q9NPP4
LDVRFHELGDVVDAF	MGAT3	221	Q09327
DDVALEGVSHFFREL	FTL	41	P02792
FLEGELIHDLLTIFV	EIF3M	231	Q7L2H7
DELFNIIQLGHFEFL	DCLK3	561	Q9C098
LAAIEDFFLEHEALG	EIF2B5	646	Q13144
AFDLFHIGHVDFLEK	PCYT2	221	Q99447
LFTEHFFAAAETILL	OR4C45	96	A6NMZ5
FVIAVLAEETHNFGL	MTTP	226	P55157
QLHLEEVRFFDVFGF	VEPH1	676	Q14D04
TFGDLAFGDIFLHLL	NELFB	451	Q8WX92
AQGFHSEIEDFLLEL	MACF1	2461	O94854
GALLLFESEFVHIVA	ATP9A	941	O75110
GESGLHEFFFLLVLV	GPR180	166	Q86V85
LHATLGVAEFFEFVL	NPHP4	981	O75161
FFHFLGSTEAILLAI	OR12D3	101	Q9UGF7
DFILEGLFDDSLTHL	OR2AE1	11	Q8NHA4
HEAFFIRCGIFLILE	PCID2	301	Q5JVF3
LFIGAEIVAVHFSAE	DUOXA2	61	Q1HG44
LLAVFFALGLEVEDH	ADCY2	61	Q08462
FALGLEVEDHVAFLI	ADCY2	66	Q08462
IHFNFELLDIGKVFT	HYDIN	461	Q4G0P3
EDFLLGLDHVADDFV	CC2D2A	251	Q9P2K1
FSIDLRSIHALEIGF	CEP120	456	Q8N960
ISLFLNILEIFHLGF	GJA9	221	P57773
TEIEEFLEHFIFLNA	DNAH14	756	Q0VDD8
LFVIFFIGLAIHGAE	CYBB	211	P04839
HGEFALLTIEEESLF	GEN1	431	Q17RS7
NLVFSIFEFVHALLE	IPO9	331	Q96P70
DELLHFFQIVTDSLF	IQCB1	136	Q15051
EHLEGALDRFAQFFL	IDE	156	P14735
HFEGFFDLIAIVAGL	KDELR1	171	P24390
LEAAFFEGHFLKVLF	FHIP2A	626	Q5W0V3
DVLILSFFISEEHGF	IFT140	691	Q96RY7
VLDALVFHFLGFRTE	BYSL	356	Q13895
FEDIRAFLGALLDHF	COL6A6	1981	A6NMZ7
SHAFFRELDIEVFSI	FANCD2	921	Q9BXW9
SLLRTHDFDGLDLFF	OVGP1	126	Q12889
TIPVHVLFFSFLEDD	PGAP3	291	Q96FM1
FLLDTADVALAEFFL	PLEKHM2	681	Q8IWE5
IDHFFGGAEVFLLVV	OR4A5	101	Q8NH83
IEHLFGDTDVFLLVV	OR4A8	101	P0C604
FFHFFGVAEILLIVV	OR4B1	101	Q8NGF8
DHSLFGILEFISVAV	FGF20	91	Q9NP95
DSTGEILFDEVFHAL	SZT2	111	Q5T011
LVVFFLFPHSVLVDD	TMEM106C	101	Q9BVX2
GTEFEGAVIALFHLL	SEC61A2	206	Q9H9S3
IGVDDVFLLAHAFTE	PTCH2	466	Q9Y6C5
DLLTDIPVHFDFLFS	ENTPD4	196	Q9Y227
DVDHDFFLLFSVVDE	HEPH	221	Q9BQS7
DELDTSFFAREGILH	RHBDF1	256	Q96CC6
GVDDVFLLAHAFSET	PTCH1	511	Q13635
DFIILIDGLNEAEFH	TANC2	536	Q9HCD6
HFIGVLDIAGFEIFE	MYH3	456	P11055
DGFLRVFNFDSVELH	WDR20	241	Q8TBZ3
HFILEEAITGDFALV	OXCT1	196	P55809
IFLEESLSFGVLGEH	SPTLC1	271	O15269
LITFVGHVSFFKEAD	ABCC8	556	Q09428
ILFHALLFGTDFVEE	B3GALT9	21	A8MXE2
FDLFLVIHHLFAFLG	CLN8	131	Q9UBY8
VKTLVFFFLESELHE	STAG2	461	Q8N3U4
IDTFIEHLFALAVDD	TNPO2	211	O14787
IFTEEILHKFFLEAG	WDR72	496	Q3MJ13
LHEFVSFEDFQVEVL	UBR1	631	Q8IWV7
ESVGFHFLTIIHERF	TEX11	351	Q8IYF3
LVRAHFLQGALFEEE	STAB1	1051	Q9NY15
IFVVLHSFTDAIFDE	DCT	391	P40126
LEFLPFHFLLATASE	WDR46	281	O15213
TVFKLLQEHLGEFIF	ZC3H7A	556	Q8IWR0
IIFEHLEGLSQVFSD	ZMYM6	1186	O95789
GAETHFDQLEDVFLL	SEMA3G	301	Q9NS98
LHIFLEIKADIGFSF	TRANK1	506	O15050
GVISGLFELLFADHV	VIRMA	481	Q69YN4
ILAGFLASVIDVDHF	TMEM267	81	Q0VDI3
LASVIDVDHFFLAGS	TMEM267	86	Q0VDI3
GHIFLLDRDVDFVTA	VPS33B	226	Q9H267