Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	neuronal stem cell population maintenance	FOXO1 FOXO3 PROX1	1.13e-05	26	35	3	GO:0097150
GeneOntologyCellularComponent	COPI vesicle coat	COPG2 COPG1	2.48e-04	13	38	2	GO:0030126
GeneOntologyCellularComponent	COPI-coated vesicle membrane	COPG2 COPG1	5.40e-04	19	38	2	GO:0030663
Domain	TCEAL1	TCEAL6 TCEAL3 TCEAL5	6.47e-07	9	38	3	IPR010370
Domain	BEX	TCEAL6 TCEAL3 TCEAL5	2.78e-06	14	38	3	PF04538
Domain	TF_A-like/BEX	TCEAL6 TCEAL3 TCEAL5	2.78e-06	14	38	3	IPR021156
Domain	FOXO_KIX-bd	FOXO1 FOXO3	4.03e-06	2	38	2	IPR032068
Domain	Coatomer_gsu	COPG2 COPG1	4.03e-06	2	38	2	IPR017106
Domain	Coatomer_g_Cpla	COPG2 COPG1	4.03e-06	2	38	2	IPR032154
Domain	COP-gamma_platf	COPG2 COPG1	4.03e-06	2	38	2	PF08752
Domain	Coatomer_g_Cpla	COPG2 COPG1	4.03e-06	2	38	2	PF16381
Domain	Coatomer_gsu_app_Ig-like-sub	COPG2 COPG1	4.03e-06	2	38	2	IPR013040
Domain	-	COPG2 COPG1	4.03e-06	2	38	2	2.60.40.1480
Domain	FOXO_KIX_bdg	FOXO1 FOXO3	4.03e-06	2	38	2	PF16675
Domain	FOXO-TAD	FOXO1 FOXO3	1.21e-05	3	38	2	IPR032067
Domain	FOXO-TAD	FOXO1 FOXO3	1.21e-05	3	38	2	PF16676
Domain	-	COPG2 COPG1	2.41e-05	4	38	2	3.30.310.30
Domain	Clathrin_a/coatomer_app_sub_C	COPG2 COPG1	2.41e-05	4	38	2	IPR015873
Domain	Coatomer/calthrin_app_sub_C	COPG2 COPG1	1.12e-04	8	38	2	IPR009028
Domain	Coatomer/clathrin_app_Ig-like	COPG2 COPG1	2.63e-04	12	38	2	IPR013041
Domain	Clathrin/coatomer_adapt-like_N	COPG2 COPG1	4.16e-04	15	38	2	IPR002553
Domain	Adaptin_N	COPG2 COPG1	4.16e-04	15	38	2	PF01602
Domain	ARM-type_fold	DIAPH1 COPG2 BZW1 COPG1 USP24	5.87e-04	339	38	5	IPR016024
Domain	PH	PLCL1 ARHGEF3 IQSEC2 MPRIP	2.38e-03	278	38	4	SM00233
Domain	PH_DOMAIN	PLCL1 ARHGEF3 IQSEC2 MPRIP	2.41e-03	279	38	4	PS50003
Domain	PH_domain	PLCL1 ARHGEF3 IQSEC2 MPRIP	2.44e-03	280	38	4	IPR001849
Domain	TF_fork_head_CS_2	FOXO1 FOXO3	3.94e-03	46	38	2	IPR030456
Domain	TF_fork_head_CS_1	FOXO1 FOXO3	4.11e-03	47	38	2	IPR018122
Domain	FORK_HEAD_3	FOXO1 FOXO3	4.46e-03	49	38	2	PS50039
Domain	FH	FOXO1 FOXO3	4.46e-03	49	38	2	SM00339
Domain	FORK_HEAD_1	FOXO1 FOXO3	4.46e-03	49	38	2	PS00657
Domain	FORK_HEAD_2	FOXO1 FOXO3	4.46e-03	49	38	2	PS00658
Domain	Forkhead	FOXO1 FOXO3	4.46e-03	49	38	2	PF00250
Domain	Fork_head_dom	FOXO1 FOXO3	4.46e-03	49	38	2	IPR001766
Domain	HMG_box_dom	CIC PROX1	7.73e-03	65	38	2	IPR009071
Domain	-	PLCL1 ARHGEF3 IQSEC2 MPRIP	7.96e-03	391	38	4	2.30.29.30
Domain	HEAT_REPEAT	COPG2 COPG1	8.92e-03	70	38	2	PS50077
Domain	USP_1	USP53 USP24	8.92e-03	70	38	2	PS00972
Domain	UCH	USP53 USP24	9.17e-03	71	38	2	PF00443
Domain	USP_2	USP53 USP24	9.17e-03	71	38	2	PS00973
Domain	USP_3	USP53 USP24	9.42e-03	72	38	2	PS50235
Domain	USP_dom	USP53 USP24	9.42e-03	72	38	2	IPR028889
Domain	Peptidase_C19_UCH	USP53 USP24	9.42e-03	72	38	2	IPR001394
Domain	PH_dom-like	PLCL1 ARHGEF3 IQSEC2 MPRIP	1.07e-02	426	38	4	IPR011993
Pathway	REACTOME_REGULATION_OF_FOXO_TRANSCRIPTIONAL_ACTIVITY_BY_ACETYLATION	FOXO1 FOXO3	4.51e-05	6	25	2	MM15660
Pathway	REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_CELL_CYCLE_GENES	FOXO1 FOXO3	6.31e-05	7	25	2	MM15661
Pathway	REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_NUCLEUS	FOXO1 FOXO3	1.35e-04	10	25	2	M27095
Pathway	REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_NUCLEUS	FOXO1 FOXO3	1.35e-04	10	25	2	MM14778
Pathway	REACTOME_REGULATION_OF_FOXO_TRANSCRIPTIONAL_ACTIVITY_BY_ACETYLATION	FOXO1 FOXO3	1.35e-04	10	25	2	M27945
Pathway	WP_NAD_METABOLISM_SIRTUINS_AND_AGING	FOXO1 FOXO3	1.64e-04	11	25	2	M39439
Pathway	REACTOME_REGULATION_OF_LOCALIZATION_OF_FOXO_TRANSCRIPTION_FACTORS	FOXO1 FOXO3	1.97e-04	12	25	2	MM15657
Pathway	REACTOME_REGULATION_OF_LOCALIZATION_OF_FOXO_TRANSCRIPTION_FACTORS	FOXO1 FOXO3	1.97e-04	12	25	2	M27939
Pathway	REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_CELL_DEATH_GENES	FOXO1 FOXO3	3.57e-04	16	25	2	M27940
Pathway	REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_CELL_CYCLE_GENES	FOXO1 FOXO3	4.04e-04	17	25	2	M27946
Pathway	BIOCARTA_AKT_PATHWAY	FOXO1 FOXO3	6.82e-04	22	25	2	M15258
Pathway	REACTOME_FOXO_MEDIATED_TRANSCRIPTION	FOXO1 FOXO3	6.82e-04	22	25	2	MM15656
Pathway	KEGG_MEDICUS_REFERENCE_COPI_VESICLE_FORMATION	COPG2 COPG1	7.47e-04	23	25	2	M47772
Pathway	BIOCARTA_AKT_PATHWAY	FOXO1 FOXO3	9.56e-04	26	25	2	MM1345
Pathway	PID_HDAC_CLASSIII_PATHWAY	FOXO1 FOXO3	9.56e-04	26	25	2	M32
Pathway	REACTOME_CONSTITUTIVE_SIGNALING_BY_AKT1_E17K_IN_CANCER	FOXO1 FOXO3	9.56e-04	26	25	2	M27558
Pathway	REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_OXIDATIVE_STRESS_METABOLIC_AND_NEURONAL_GENES	FOXO1 FOXO3	1.27e-03	30	25	2	M27941
Pathway	WP_PI3KAKTMTOR_SIGNALING_AND_THERAPEUTIC_OPPORTUNITIES_IN_PROSTATE_CANCER	FOXO1 FOXO3	1.45e-03	32	25	2	M39445
Pathway	PID_PI3KCI_AKT_PATHWAY	FOXO1 FOXO3	1.73e-03	35	25	2	M249
Pathway	WP_LEUKOCYTEINTRINSIC_HIPPO_PATHWAY_FUNCTIONS	FOXO1 FOXO3	1.73e-03	35	25	2	M39430
Pubmed	Foxo1 deletion promotes the growth of new lymphatic valves.	FOXO1 FOXO3 PROX1	4.81e-09	4	38	3	34263740
Pubmed	SENP3 regulates the global protein turnover and the Sp1 level via antagonizing SUMO2/3-targeted ubiquitination and degradation.	MCM3 COPG2 COPG1 XAB2	7.34e-07	64	38	4	26511642
Pubmed	GxE interactions between FOXO genotypes and drinking tea are significantly associated with prevention of cognitive decline in advanced age in China.	FOXO1 FOXO3	1.16e-06	2	38	2	24895270
Pubmed	Association study to evaluate Foxo1 and Foxo3 gene polymorphisms in polycystic ovary syndrome: a preliminary case-control study and in silico analysis.	FOXO1 FOXO3	1.16e-06	2	38	2	36790598
Pubmed	FoxO transcription factors promote AKT Ser473 phosphorylation and renal tumor growth in response to pharmacologic inhibition of the PI3K-AKT pathway.	FOXO1 FOXO3	1.16e-06	2	38	2	24448243
Pubmed	Reduced FOXO1 expression accelerates skin wound healing and attenuates scarring.	FOXO1 FOXO3	1.16e-06	2	38	2	25010393
Pubmed	FoxO transcription factors support oxidative stress resistance in human chondrocytes.	FOXO1 FOXO3	1.16e-06	2	38	2	25186470
Pubmed	FoxO transcription factors promote cardiomyocyte survival upon induction of oxidative stress.	FOXO1 FOXO3	1.16e-06	2	38	2	21159781
Pubmed	Dysregulated FOXO transcription factors in articular cartilage in aging and osteoarthritis.	FOXO1 FOXO3	1.16e-06	2	38	2	24269635
Pubmed	Foxo transcription factors blunt cardiac hypertrophy by inhibiting calcineurin signaling.	FOXO1 FOXO3	1.16e-06	2	38	2	16952979
Pubmed	Differential expression of FOXO1 and FOXO3a confers resistance to oxidative cell death upon endometrial decidualization.	FOXO1 FOXO3	1.16e-06	2	38	2	16709600
Pubmed	Mitf regulation of Dia1 controls melanoma proliferation and invasiveness.	DIAPH1 MITF	1.16e-06	2	38	2	17182868
Pubmed	FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress.	FOXO1 FOXO3	1.16e-06	2	38	2	17254970
Pubmed	A novel function of FoxO transcription factors in thrombin-stimulated vascular smooth muscle cell proliferation.	FOXO1 FOXO3	1.16e-06	2	38	2	22552808
Pubmed	Foxo in T Cells Regulates Thermogenic Program through Ccr4/Ccl22 Axis.	FOXO1 FOXO3	1.16e-06	2	38	2	31756626
Pubmed	Optimal B-cell proliferation requires phosphoinositide 3-kinase-dependent inactivation of FOXO transcription factors.	FOXO1 FOXO3	1.16e-06	2	38	2	15069012
Pubmed	Discovery of a Novel, Isothiazolonaphthoquinone-Based Small Molecule Activator of FOXO Nuclear-Cytoplasmic Shuttling.	FOXO1 FOXO3	1.16e-06	2	38	2	27936162
Pubmed	Lower FOXO3 mRNA expression in granulosa cells is involved in unexplained infertility.	FOXO1 FOXO3	1.16e-06	2	38	2	28621049
Pubmed	Age-related reduction in the expression of FOXO transcription factors and correlations with intervertebral disc degeneration.	FOXO1 FOXO3	1.16e-06	2	38	2	28430387
Pubmed	Mutational screening of FOXO3A and FOXO1A in women with premature ovarian failure.	FOXO1 FOXO3	1.16e-06	2	38	2	16979636
Pubmed	FOXO1 and FOXO3 Cooperatively Regulate Innate Lymphoid Cell Development.	FOXO1 FOXO3	1.16e-06	2	38	2	35757763
Pubmed	Involvement of Foxo transcription factors in angiogenesis and postnatal neovascularization.	FOXO1 FOXO3	1.16e-06	2	38	2	16100571
Pubmed	Helicobacter pylori-associated regulation of forkhead transcription factors FoxO1/3a in human gastric cells.	FOXO1 FOXO3	1.16e-06	2	38	2	22515357
Pubmed	[Analysis of FOXO1A and FOXO3A Gene Allele Association with Human Longevity].	FOXO1 FOXO3	1.16e-06	2	38	2	27529982
Pubmed	Kinetics of nuclear-cytoplasmic translocation of Foxo1 and Foxo3A in adult skeletal muscle fibers.	FOXO1 FOXO3	1.16e-06	2	38	2	22932683
Pubmed	Both FOXO3a and FOXO1 are involved in the HGF-protective pathway against apoptosis in endothelial cells.	FOXO1 FOXO3	1.16e-06	2	38	2	25952685
Pubmed	The high protein expression of FOXO3, but not that of FOXO1, is associated with markers of good prognosis.	FOXO1 FOXO3	1.16e-06	2	38	2	32332845
Pubmed	Association study to evaluate FoxO1 and FoxO3 gene in CHD in Han Chinese.	FOXO1 FOXO3	1.16e-06	2	38	2	24489705
Pubmed	FOXOs in the impaired heart: New therapeutic targets for cardiac diseases.	FOXO1 FOXO3	1.16e-06	2	38	2	27890702
Pubmed	Effects of FOXO genotypes on longevity: a biodemographic analysis.	FOXO1 FOXO3	1.16e-06	2	38	2	20884733
Pubmed	Endothelial-specific FoxO1 depletion prevents obesity-related disorders by increasing vascular metabolism and growth.	FOXO1 FOXO3	1.16e-06	2	38	2	30511639
Pubmed	FoxO1 is a positive regulator of bone formation by favoring protein synthesis and resistance to oxidative stress in osteoblasts.	FOXO1 FOXO3	1.16e-06	2	38	2	20142102
Pubmed	FOXO3 induces FOXO1-dependent autophagy by activating the AKT1 signaling pathway.	FOXO1 FOXO3	1.16e-06	2	38	2	22931788
Pubmed	Foxo transcription factors control regulatory T cell development and function.	FOXO1 FOXO3	1.16e-06	2	38	2	21167754
Pubmed	Genetic association of FOXO1A and FOXO3A with longevity trait in Han Chinese populations.	FOXO1 FOXO3	1.16e-06	2	38	2	19793722
Pubmed	P. gingivalis modulates keratinocytes through FOXO transcription factors.	FOXO1 FOXO3	1.16e-06	2	38	2	24265696
Pubmed	Forkhead box, class O transcription factors in brain: regulation and behavioral manifestation.	FOXO1 FOXO3	1.16e-06	2	38	2	18823877
Pubmed	Forkhead box class O transcription factors in liver function and disease.	FOXO1 FOXO3	1.16e-06	2	38	2	23855308
Pubmed	Class IIa histone deacetylases are hormone-activated regulators of FOXO and mammalian glucose homeostasis.	FOXO1 FOXO3	1.16e-06	2	38	2	21565617
Pubmed	Different roles of Foxo1 and Foxo3 in the control of endothelial cell morphology.	FOXO1 FOXO3	1.16e-06	2	38	2	19747349
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	FOXO1 FOXO3 COPG2 LIMCH1 ARHGEF3 COPG1 KIAA1217 IQSEC2 MITF	1.36e-06	1038	38	9	26673895
Pubmed	Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism sustained by gene conversion events.	TCEAL6 TCEAL3 TCEAL5	2.40e-06	24	38	3	16221301
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	USP53 FOXO1 FOXO3 LIMCH1 CIC KIAA1217 IQSEC2 MPRIP	3.46e-06	861	38	8	36931259
Pubmed	A mutant allele encoding DNA binding-deficient FoxO1 differentially regulates hepatic glucose and lipid metabolism.	FOXO1 FOXO3	3.48e-06	3	38	2	25576059
Pubmed	FOXO transcription factors protect against the diet-induced fatty liver disease.	FOXO1 FOXO3	3.48e-06	3	38	2	28300161
Pubmed	Endothelial FoxO proteins impair insulin sensitivity and restrain muscle angiogenesis in response to a high-fat diet.	FOXO1 FOXO3	3.48e-06	3	38	2	27235148
Pubmed	Inhibition of FOXO1/3 promotes vascular calcification.	FOXO1 FOXO3	3.48e-06	3	38	2	25378413
Pubmed	STAT3 protein promotes T-cell survival and inhibits interleukin-2 production through up-regulation of Class O Forkhead transcription factors.	FOXO1 FOXO3	3.48e-06	3	38	2	21730069
Pubmed	FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis.	FOXO1 FOXO3	3.48e-06	3	38	2	17254969
Pubmed	FoxO6, a novel member of the FoxO class of transcription factors with distinct shuttling dynamics.	FOXO1 FOXO3	3.48e-06	3	38	2	12857750
Pubmed	Aberrant miR-182 expression promotes melanoma metastasis by repressing FOXO3 and microphthalmia-associated transcription factor.	FOXO3 MITF	3.48e-06	3	38	2	19188590
Pubmed	Insulin-like growth factor-I induces the phosphorylation and nuclear exclusion of forkhead transcription factors in human neuroblastoma cells.	FOXO1 FOXO3	3.48e-06	3	38	2	16133873
Pubmed	Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues.	FOXO1 FOXO3	3.48e-06	3	38	2	10880363
Pubmed	CTCF regulates the FoxO signaling pathway to affect the progression of prostate cancer.	FOXO1 FOXO3	3.48e-06	3	38	2	30873749
Pubmed	FoxO transcription factors 1 regulate mouse preimplantation embryo development.	FOXO1 FOXO3	3.48e-06	3	38	2	31396850
Pubmed	FOXO1, FOXO3, AND FOXO4 are differently expressed during mouse oocyte maturation and preimplantation embryo development.	FOXO1 FOXO3	3.48e-06	3	38	2	25929834
Pubmed	Phosphorylation of p66Shc and forkhead proteins mediates Abeta toxicity.	FOXO1 FOXO3	3.48e-06	3	38	2	15837797
Pubmed	Integrated control of hepatic lipogenesis versus glucose production requires FoxO transcription factors.	FOXO1 FOXO3	3.48e-06	3	38	2	25307742
Pubmed	Dysregulation of FOXO transcription factors in Epstein-Barr virus-associated gastric carcinoma.	FOXO1 FOXO3	3.48e-06	3	38	2	31712122
Pubmed	Functional regulation of FoxO1 in neural stem cell differentiation.	FOXO1 FOXO3	3.48e-06	3	38	2	26470727
Pubmed	Deletion of FoxO1, 3, and 4 in Osteoblast Progenitors Attenuates the Loss of Cancellous Bone Mass in a Mouse Model of Type 1 Diabetes.	FOXO1 FOXO3	3.48e-06	3	38	2	27491024
Pubmed	FoxO1 is required for physiological cardiac hypertrophy induced by exercise but not by constitutively active PI3K.	FOXO1 FOXO3	3.48e-06	3	38	2	33577435
Pubmed	FOXO transcription factors are mechanosensitive and their regulation is altered with aging in the respiratory pump.	FOXO1 FOXO3	3.48e-06	3	38	2	18272820
Pubmed	Loss of FoxOs in muscle reveals sex-based differences in insulin sensitivity but mitigates diet-induced obesity.	FOXO1 FOXO3	3.48e-06	3	38	2	31767172
Pubmed	Inhibition of FoxO transcriptional activity prevents muscle fiber atrophy during cachexia and induces hypertrophy.	FOXO1 FOXO3	3.48e-06	3	38	2	22102632
Pubmed	Polymorphisms in FOXO gene family and association analysis with BMI.	FOXO1 FOXO3	3.48e-06	3	38	2	16571842
Pubmed	Forkhead BoxO transcription factors restrain exercise-induced angiogenesis.	FOXO1 FOXO3	3.48e-06	3	38	2	25063823
Pubmed	FOXOs attenuate bone formation by suppressing Wnt signaling.	FOXO1 FOXO3	3.48e-06	3	38	2	23867625
Pubmed	The deubiquitinating protein USP24 interacts with DDB2 and regulates DDB2 stability.	USP53 USP24	3.48e-06	3	38	2	23159851
Pubmed	mTOR complex 2 controls glycolytic metabolism in glioblastoma through FoxO acetylation and upregulation of c-Myc.	FOXO1 FOXO3	3.48e-06	3	38	2	24140020
Pubmed	The FoxO transcription factors and metabolic regulation.	FOXO1 FOXO3	3.48e-06	3	38	2	18022395
Pubmed	The Colonic Crypt Protects Stem Cells from Microbiota-Derived Metabolites.	FOXO1 FOXO3	3.48e-06	3	38	2	27264604
Pubmed	Forkhead box O transcription factors in chondrocytes regulate endochondral bone formation.	FOXO1 FOXO3	3.48e-06	3	38	2	26232637
Pubmed	FoxO transcription factors are required for hepatic HDL cholesterol clearance.	FOXO1 FOXO3	3.48e-06	3	38	2	29408809
Pubmed	AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1.	FOXO1 FOXO3	3.48e-06	3	38	2	10783894
Pubmed	Altered Plasma Profile of Antioxidant Proteins as an Early Correlate of Pancreatic β Cell Dysfunction.	FOXO1 FOXO3	3.48e-06	3	38	2	26917725
Pubmed	Nuclear Akt2 opposes limbal keratinocyte stem cell self-renewal by repressing a FOXO-mTORC1 signaling pathway.	FOXO1 FOXO3	3.48e-06	3	38	2	24123662
Pubmed	FoxO proteins mediate hypoxic induction of connective tissue growth factor in endothelial cells.	FOXO1 FOXO3	3.48e-06	3	38	2	20018872
Pubmed	The transcription of FOXO genes is stimulated by FOXO3 and repressed by growth factors.	FOXO1 FOXO3	3.48e-06	3	38	2	19244250
Pubmed	Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy.	FOXO1 FOXO3	3.48e-06	3	38	2	15109499
Pubmed	SIRT1 protein, by blocking the activities of transcription factors FoxO1 and FoxO3, inhibits muscle atrophy and promotes muscle growth.	FOXO1 FOXO3	3.48e-06	3	38	2	24003218
Pubmed	Expression of forkhead transcription factors in human granulosa cells.	FOXO1 FOXO3	3.48e-06	3	38	2	18692812
Pubmed	FoxO-mediated defense against oxidative stress in osteoblasts is indispensable for skeletal homeostasis in mice.	FOXO1 FOXO3	3.48e-06	3	38	2	20142101
Pubmed	Deletion of hepatic FoxO1/3/4 genes in mice significantly impacts on glucose metabolism through downregulation of gluconeogenesis and upregulation of glycolysis.	FOXO1 FOXO3	3.48e-06	3	38	2	24015318
Pubmed	FoxO1 Is a Novel Regulator of 20S Proteasome Subunits Expression and Activity.	FOXO1 FOXO3	3.48e-06	3	38	2	33634126
Pubmed	STAT3 protein interacts with Class O Forkhead transcription factors in the cytoplasm and regulates nuclear/cytoplasmic localization of FoxO1 and FoxO3a proteins in CD4(+) T cells.	FOXO1 FOXO3	3.48e-06	3	38	2	22761423
Pubmed	The involvement of FoxO in cell survival and chemosensitivity mediated by Mirk/Dyrk1B in ovarian cancer.	FOXO1 FOXO3	3.48e-06	3	38	2	22159921
Pubmed	Metabolic Regulation of Stem Cells and Differentiation: A Forkhead Box O Transcription Factor Perspective.	FOXO1 FOXO3	3.48e-06	3	38	2	32847377
Pubmed	FoxO family members in cancer.	FOXO1 FOXO3	3.48e-06	3	38	2	21613825
Pubmed	FOXO transcription factors enforce cell cycle checkpoints and promote survival of hematopoietic cells after DNA damage.	FOXO1 FOXO3	3.48e-06	3	38	2	19671690
Pubmed	Mitochondria Define Intestinal Stem Cell Differentiation Downstream of a FOXO/Notch Axis.	FOXO1 FOXO3	3.48e-06	3	38	2	33147486
Pubmed	Expression of FKHR, FKHRL1, and AFX genes in the rodent ovary: evidence for regulation by IGF-I, estrogen, and the gonadotropins.	FOXO1 FOXO3	3.48e-06	3	38	2	11875118
Pubmed	FOXO protects against age-progressive axonal degeneration.	FOXO1 FOXO3	3.48e-06	3	38	2	29178390
Pubmed	FoxO regulates expression of ABCA6, an intracellular ATP-binding-cassette transporter responsive to cholesterol.	FOXO1 FOXO3	3.48e-06	3	38	2	24028821
Pubmed	Interaction of gamma-COP with a transport motif in the D1 receptor C-terminus.	COPG2 COPG1	3.48e-06	3	38	2	11893085
Pubmed	Lipid availability determines fate of skeletal progenitor cells via SOX9.	FOXO1 FOXO3	3.48e-06	3	38	2	32103177
Pubmed	Evidence for AKT-independent regulation of FOXO1 and FOXO3 in haematopoietic stem and progenitor cells.	FOXO1 FOXO3	3.48e-06	3	38	2	26929388
Pubmed	FOXO responses to Porphyromonas gingivalis in epithelial cells.	FOXO1 FOXO3	3.48e-06	3	38	2	25958948
Pubmed	A 1.1-Mb segmental deletion on the X chromosome causes meiotic failure in male mice.	TCEAL6 TCEAL3 TCEAL5	3.87e-06	28	38	3	23677977
Pubmed	FOXOs support the metabolic requirements of normal and tumor cells by promoting IDH1 expression.	FOXO1 FOXO3	6.96e-06	4	38	2	25648147
Interaction	PMS2 interactions	MCM3 COPG2 ABCA2 COPG1	1.23e-05	80	36	4	int:PMS2
Interaction	YWHAH interactions	USP53 FOXO1 FOXO3 ABCA2 LIMCH1 CIC KIAA1217 IQSEC2 MPRIP MITF	1.58e-05	1102	36	10	int:YWHAH
Interaction	FOXO3B interactions	FOXO1 FOXO3	4.63e-05	6	36	2	int:FOXO3B
Interaction	TCEAL3 interactions	TCEAL3 TCEAL5	4.63e-05	6	36	2	int:TCEAL3
Interaction	BTF3 interactions	CARS1 MCM3 COPG2 LIMCH1 COPG1 KIAA1217 MPRIP PROX1	6.64e-05	799	36	8	int:BTF3
Interaction	CDC5L interactions	DIAPH1 MCM3 COPG2 BZW1 COPG1 CIC XAB2 USP24	1.07e-04	855	36	8	int:CDC5L
Interaction	PAX3 interactions	FOXO1 CIC MITF	1.09e-04	52	36	3	int:PAX3
Cytoband	2q33	PLCL1 BZW1	2.67e-04	29	38	2	2q33
Cytoband	Ensembl 112 genes in cytogenetic band chrXq22	TCEAL6 TCEAL3 TCEAL5	3.96e-04	172	38	3	chrXq22
Cytoband	Xq22.1	TCEAL6 TCEAL5	5.90e-04	43	38	2	Xq22.1
GeneFamily	Transcription elongation factor A like family	TCEAL6 TCEAL3 TCEAL5	1.72e-07	9	24	3	1216
GeneFamily	Forkhead boxes	FOXO1 FOXO3	1.48e-03	43	24	2	508
GeneFamily	Ubiquitin specific peptidases	USP53 USP24	2.49e-03	56	24	2	366
GeneFamily	G protein-coupled receptors, Class A orphans	GPR132 MAS1	4.77e-03	78	24	2	262
Coexpression	LAKE_ADULT_KIDNEY_C14_DISTAL_CONVOLUTED_TUBULE	LIMCH1 PLCL1 KIAA1217 MITF USP24	1.22e-05	208	38	5	M39233
CoexpressionAtlas	FacebaseRNAseq_e9.5_Maxillary Arch_top-relative-expression-ranked_1000	SYCP2L TCEAL3 LIMCH1 PLCL1 THSD7B ENOX1 LTBP4 MAS1 TCEAL5 MITF	5.40e-06	967	38	10	Facebase_RNAseq_e9.5_Maxillary Arch_1000
CoexpressionAtlas	FacebaseRNAseq_e9.5_Olfactory Placode_top-relative-expression-ranked_1000	SYCP2L COPG2 ABCA2 TCEAL3 PLCL1 THSD7B LTBP4 MAS1 KIAA1217 TCEAL5	5.71e-06	973	38	10	Facebase_RNAseq_e9.5_Olfactory Placode_1000
CoexpressionAtlas	FacebaseRNAseq_e8.5_Paraxial Mesoderm_top-relative-expression-ranked_500	SYCP2L TCEAL3 PLCL1 THSD7B LTBP4 MAS1 TCEAL5	2.24e-05	489	38	7	Facebase_RNAseq_e8.5_Paraxial Mesoderm_500
CoexpressionAtlas	FacebaseRNAseq_e8.5_Paraxial Mesoderm_top-relative-expression-ranked_1000	SYCP2L ABCA2 TCEAL3 PLCL1 THSD7B ENOX1 LTBP4 MAS1 TCEAL5	4.01e-05	967	38	9	Facebase_RNAseq_e8.5_Paraxial Mesoderm_1000
CoexpressionAtlas	FacebaseRNAseq_e8.5_Non-Floor Plate Neural Epithelium_top-relative-expression-ranked_1000	SYCP2L ABCA2 TCEAL3 PLCL1 THSD7B ENOX1 LTBP4 MAS1 TCEAL5	4.31e-05	976	38	9	Facebase_RNAseq_e8.5_Non-Floor Plate Neural Epithelium_1000
CoexpressionAtlas	FacebaseRNAseq_e10.5_Mandibular Arch_top-relative-expression-ranked_1000	SYCP2L TCEAL3 LIMCH1 PLCL1 THSD7B ENOX1 LTBP4 MAS1 TCEAL5	4.38e-05	978	38	9	Facebase_RNAseq_e10.5_Mandibular Arch_1000
CoexpressionAtlas	FacebaseRNAseq_ratio_e9.5_MandibularArch_vs_MaxillaryArch_top-relative-expression-ranked_500	TCEAL3 PLCL1 THSD7B LTBP4 MAS1 TCEAL5	1.91e-04	479	38	6	Facebase_RNAseq_ratio_e9.5_MandibularArch_vs_MaxillaryArch_500
CoexpressionAtlas	FacebaseRNAseq_ratio_e9.5_MandibularArch_vs_MaxillaryArch_top-relative-expression-ranked_1000	ABCA2 TCEAL3 PLCL1 THSD7B ENOX1 LTBP4 MAS1 TCEAL5	2.60e-04	967	38	8	Facebase_RNAseq_ratio_e9.5_MandibularArch_vs_MaxillaryArch_1000
CoexpressionAtlas	FacebaseRNAseq_e9.5_Facial Mesenchyne_top-relative-expression-ranked_1000	TCEAL3 LIMCH1 PLCL1 THSD7B ENOX1 LTBP4 MAS1 TCEAL5	2.62e-04	968	38	8	Facebase_RNAseq_e9.5_Facial Mesenchyne_1000
CoexpressionAtlas	FacebaseRNAseq_ratio_e9.5_MaxillaryArch_vs_Mandibular_top-relative-expression-ranked_1000	ABCA2 TCEAL3 PLCL1 THSD7B ENOX1 LTBP4 MAS1 TCEAL5	2.69e-04	972	38	8	Facebase_RNAseq_ratio_e9.5_MaxillaryArch_vs_Mandibular_1000
CoexpressionAtlas	FacebaseRNAseq_e9.5_Maxillary Arch_top-relative-expression-ranked_2500_k-means-cluster#5	TCEAL6 PLCL1 MAS1 IQSEC2 TCEAL5 MITF	3.29e-04	530	38	6	Facebase_RNAseq_e9.5_Maxillary Arch_2500_K5
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	LIMCH1 PLCL1 ARHGEF3 PROX1 MITF USP24	1.29e-08	190	38	6	e252e925600e6457fa6e362a55217f4cffa75cdb
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	LIMCH1 ARHGEF3 PROX1 MITF USP24	5.56e-07	189	38	5	7eb8f5a951e80f1cfac4d7c9eb169f4eb100c917
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PLCL1 ARHGEF3 PROX1 MITF USP24	5.56e-07	189	38	5	977a813e5d7a5a561c1fced2bbf21c20056b88d8
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	LIMCH1 ARHGEF3 PROX1 MITF USP24	5.56e-07	189	38	5	975c0f079903ae36b0ffa54e86294d42ec7697de
ToppCell	BAL-Control-Myeloid-cDC-cDC-cDC_10\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	USP53 LIMCH1 PLCL1 ENOX1 GPR132	6.01e-07	192	38	5	2c69f3f388b69fb1c1968c923cdbab90658883dd
ToppCell	BAL-Control-Myeloid-cDC-cDC-cDC_10\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	USP53 LIMCH1 PLCL1 ENOX1 GPR132	6.01e-07	192	38	5	d5a7b546ebfb2e757dd9c64cb1b651f6ed0e0fc7
ToppCell	facs-Pancreas-Exocrine-24m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BRMS1L ENOX1 CIC USP24	1.14e-05	164	38	4	b895674ed2df87db8fbfb30b7e31620945588491
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT2_L6_FEZF2-Exc_L6_FEZF2_SLITRK6\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	THSD7B KIAA1217 TNIP3 MITF	1.28e-05	169	38	4	1c9e54e7b14eb99996590fb93b257cf881a9f184
ToppCell	BAL-Mild-Myeloid-cDC-cDC-cDC_10\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	LIMCH1 PLCL1 ENOX1 GPR132	1.64e-05	180	38	4	32d871738a24071b70084a7e80148a516110c78b
ToppCell	BAL-Mild-Myeloid-cDC-cDC-cDC_10\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	LIMCH1 PLCL1 ENOX1 GPR132	1.64e-05	180	38	4	067ca8a15228c7f3b3bc7aecbc9b1611ca05e176
ToppCell	IPF-Myeloid-DC_Mature\|World / Disease state, Lineage and Cell class	LIMCH1 PLCL1 ENOX1 GPR132	1.87e-05	186	38	4	d0d3953d9b199e0e792990b8551efb993393fe7e
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_VIP_PRSS8\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	THSD7B FAM83C PROX1 MITF	1.87e-05	186	38	4	fef543f188edb0d1704d9c6ace366a0f8017bf53
ToppCell	5'-GW_trimst-2-LymphNode-Mesenchymal-Pericytes-angiogenic_pericyte\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	L1TD1 PLCL1 THSD7B MPRIP	1.91e-05	187	38	4	b8f88599e22b9b345c7ec3bbecd87a8b2a033f9f
ToppCell	IPF-Myeloid-DC_Mature\|IPF / Disease state, Lineage and Cell class	LIMCH1 PLCL1 ENOX1 GPR132	1.91e-05	187	38	4	63e0304a0183b69aebb0d1a4640a506a0d6fb6e9
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	LIMCH1 GPR132 MITF USP24	1.91e-05	187	38	4	f124d2c699b717b7c02a1a70493f515b83dc2f4c
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	LIMCH1 PROX1 MITF USP24	1.95e-05	188	38	4	eec3d353e51358db4c7621265ee0fdd4298e5b0e
ToppCell	COPD-Myeloid-DC_Mature\|COPD / Disease state, Lineage and Cell class	LIMCH1 PLCL1 ENOX1 GPR132	1.95e-05	188	38	4	de93ccb53edb8599da9e312db0e3af604c21f673
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	LIMCH1 PROX1 MITF USP24	1.95e-05	188	38	4	bc089cd73d283ed7d2ecbb3936673b4edc89f666
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	USP53 PLCL1 ENOX1 USP24	1.99e-05	189	38	4	f51cdc9a47371cab8ed9ae63a6f14da07ede446c
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	LIMCH1 GPR132 MITF USP24	1.99e-05	189	38	4	e32172ad09e93f6ac6ea2b92145b2b73003f7970
ToppCell	RV-06._Ventricular_Cardiomyocyte_II\|World / Chamber and Cluster_Paper	LIMCH1 PLCL1 ENOX1 MITF	1.99e-05	189	38	4	5e80c47f63980904c4c1ff02c201b67b456a0974
ToppCell	RV-15._Ventricular_Cardiomyocyte_III\|World / Chamber and Cluster_Paper	DIAPH1 PLCL1 ENOX1 KIAA1217	1.99e-05	189	38	4	0a82931b5f6c0a6427ca3edd5e2235ac49099d40
ToppCell	LV-06._Ventricular_Cardiomyocyte_II\|World / Chamber and Cluster_Paper	LIMCH1 PLCL1 ENOX1 MITF	2.03e-05	190	38	4	de5ef606a002f85c2e0e3a36c1f259d0b85a76ff
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PLCL1 ENOX1 PROX1 USP24	2.03e-05	190	38	4	b94df372bc08de11585b2467dba8c8fffff5cd92
ToppCell	LV-06._Ventricular_Cardiomyocyte_II\|LV / Chamber and Cluster_Paper	LIMCH1 PLCL1 ENOX1 MITF	2.08e-05	191	38	4	25f3eb34f4e70761e81e84c8a5829f216108cbc6
ToppCell	LV-02._Fibroblast_II\|World / Chamber and Cluster_Paper	USP53 FOXO1 FOXO3 LTBP4	2.08e-05	191	38	4	d36565257ccba8c1bbed2c1c01be66a9cbb5f834
ToppCell	Mild-Myeloid-mDC-\|Mild / Condition, Lineage, Cell class and cell subclass	LIMCH1 PLCL1 ENOX1 GPR132	2.12e-05	192	38	4	8520b3fdf4508ac66f7918da613abc928ab5832a
ToppCell	Mild-Myeloid-mDC\|Mild / Condition, Lineage, Cell class and cell subclass	LIMCH1 PLCL1 ENOX1 GPR132	2.12e-05	192	38	4	da3952bd5c96242c15eb76678d0608ae2926a16e
ToppCell	10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte-C\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ABCA2 LIMCH1 PLCL1 PROX1	2.12e-05	192	38	4	3ce5dbde41aeb73d49f2c7991d34682f0827fa5a
ToppCell	10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte-D\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ABCA2 PLCL1 ENOX1 PROX1	2.16e-05	193	38	4	947200ef6c3a2e35ad7e6b4af29d92384bdf73f5
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	USP53 FOXO1 LIMCH1 LTBP4	2.16e-05	193	38	4	b3ad5ff480d99217f36cc7471e5a96a519ddb409
ToppCell	Control-Myeloid-Migratory_DC\|Control / Condition, Lineage and Cell class	LIMCH1 PLCL1 ENOX1 GPR132	2.21e-05	194	38	4	374076e60dcee83eb1814aa6b55b77668909f40b
ToppCell	facs-Kidney-nan-3m-Endothelial\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ITPRIP LIMCH1 ARHGEF3 LTBP4	2.21e-05	194	38	4	5fa2dfca32cca4abfda0af90b83f2b2a826f9b6e
ToppCell	facs-Kidney-nan-3m-Endothelial-fenestrated_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ITPRIP LIMCH1 ARHGEF3 LTBP4	2.21e-05	194	38	4	04df35246287815bdd28adaf885bdb98cf49524e
ToppCell	facs-Kidney-nan-3m-Endothelial-Pecam____fenestrated_capillary_endothelial\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ITPRIP LIMCH1 ARHGEF3 LTBP4	2.21e-05	194	38	4	90928d6c96c6304ae35dcc0275f7889de93da100
ToppCell	LA-02._Fibroblast_II\|LA / Chamber and Cluster_Paper	USP53 FOXO1 FOXO3 LTBP4	2.21e-05	194	38	4	234d1494c114cce77c619708bbcd8d5ce805f19b
ToppCell	droplet-Lung-nan-3m-Mesenchymal-Myofibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LDHD TCEAL3 THSD7B LTBP4	2.25e-05	195	38	4	d32716a12014522492becbde1088dc1106308490
ToppCell	Control-Myeloid-Migratory_DC\|Myeloid / Condition, Lineage and Cell class	LIMCH1 PLCL1 ENOX1 GPR132	2.25e-05	195	38	4	9f1ad04abc6a6c5e093ea24b60732871b1fad5a4
ToppCell	droplet-Lung-nan-3m-Mesenchymal-pulmonary_interstitial_fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LDHD TCEAL3 THSD7B LTBP4	2.25e-05	195	38	4	b913d5df50c88a3a255f516a1aa42419c6701e1e
ToppCell	BAL-Mild-cDC_10\|Mild / Compartment, Disease Groups and Clusters	LIMCH1 PLCL1 ENOX1 GPR132	2.34e-05	197	38	4	c0550d41dd5619b369b590f3d6a61154dd7b2cab
ToppCell	BAL-Severe-cDC_10\|Severe / Compartment, Disease Groups and Clusters	LIMCH1 PLCL1 ENOX1 GPR132	2.44e-05	199	38	4	54bdadd04abaf8caa948b0177c037bc089ca07e6
ToppCell	Neuronal-Inhibitory-iA-iA_1(SST_PAX6)-SST\|Neuronal / cells hierarchy compared to all cells using T-Statistic	FOXO1 THSD7B PROX1 MITF	2.48e-05	200	38	4	53d5e427f0cbf5cf0b63efe4ec01da302f555704
ToppCell	Tracheal-10x3prime_v2-Stromal-Peri/Epineurial_-NAF_epineurial\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	USP53 FOXO1 BZW1 LTBP4	2.48e-05	200	38	4	24e13b6d9d2d8b29df1f02544ea9c50084d9e75c
ToppCell	Neuronal-Excitatory-eE(FEZF2_SLC17A7)-eE_2\|Neuronal / cells hierarchy compared to all cells using T-Statistic	THSD7B KIAA1217 TNIP3 MITF	2.48e-05	200	38	4	d31e26387d879ee30731c497cea6aaf4746e40d9
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-3m-Neuronal-Intermediate\|3m / Sample Type, Dataset, Time_group, and Cell type.	FOXO3 COPG1 LTBP4 TCEAL5	2.48e-05	200	38	4	cbd0b9188a94778ffa539912aeb2a4378f0ab88f
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Igfbp6_Car10\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	PLCL1 THSD7B PROX1	1.72e-04	127	38	3	f808c727c0817ed10e76eaffa9493a516e9a6b50
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-2M-Stem_cells-neuroepithelial-like_cells\|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.	PLCL1 BRMS1L PROX1	1.72e-04	127	38	3	9071cd0953c8bb6746dc9cd13d153e3d6ef40b08
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW10-OPC_related-Oligodendrocyte/OPC\|GW10 / Sample Type, Dataset, Time_group, and Cell type.	FOXO1 COPG2 TNIP3	2.87e-04	151	38	3	4533bccc996395f74b16af939ce79b6fe253c073
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW10-OPC_related\|GW10 / Sample Type, Dataset, Time_group, and Cell type.	FOXO1 COPG2 TNIP3	2.87e-04	151	38	3	edb2f59789c295838d2030b80c792cbea25eaa3d
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Lamp5-Lamp5_Ntn1_Npy2r\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	FOXO1 NDP PROX1	2.92e-04	152	38	3	8ff5a178a8f3550d89a003c0858820aab3773386
ToppCell	Ionocyte\|World / shred by cell class for nasal brushing	PLCL1 ABHD16B PROX1	3.04e-04	154	38	3	6b78fb0c96fc7b5e901c39b3424f4aa8d0a6b9cf
ToppCell	356C-Fibroblasts-Fibroblast-D-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	GPR132 TNIP3 PROX1	3.34e-04	159	38	3	299e2162a82e31196d7f3a110c2db622349edfff
ToppCell	356C-Fibroblasts-Fibroblast-D\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	GPR132 TNIP3 PROX1	3.34e-04	159	38	3	0a3a363b30a8c741e1a3e2525725108d03c21776
ToppCell	PND14-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TCEAL6 TCEAL3 TCEAL5	3.40e-04	160	38	3	8624f101828efd32cdd38a65df8d94d690720a63
ToppCell	PND14-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC-ASMC_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TCEAL6 TCEAL3 TCEAL5	3.40e-04	160	38	3	9de3dd6b9d4b51314d60b3b01f4132bcfa2dfc18
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PLCL1 ENOX1 PROX1	3.40e-04	160	38	3	03b88dc7ad41c6ae443cab7e77ec666340bf432e
ToppCell	368C-Myeloid-Dendritic-cDC_activated\|368C / Donor, Lineage, Cell class and subclass (all cells)	PLCL1 ENOX1 MAS1	3.40e-04	160	38	3	bcd90ef96464bd901b87b94c696de70c113bfd03
ToppCell	facs-Pancreas-Exocrine-18m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LIMCH1 BRMS1L USP24	3.59e-04	163	38	3	132aece9c79499b4bb3c2bde68d3d7202e1d8772
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c09-SLC4A10\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	ITPRIP ABCA2 BRMS1L	3.65e-04	164	38	3	a5227971a71345854e0538e42da684de87febda0
ToppCell	368C-Myeloid-Dendritic-cDC_activated\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	PLCL1 ENOX1 MAS1	3.65e-04	164	38	3	67c636a2cc32e56c6186dc7e779cc19af04639d2
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_VIP_PRSS8\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	THSD7B FAM83C PROX1	3.65e-04	164	38	3	ed7e0c8ccad7d19b9cc72d70391936ff5e698f28
ToppCell	Basal_cells-IPF_01\|World / lung cells shred on cell class, cell subclass, sample id	THSD7B LTBP4 KIAA1217	3.78e-04	166	38	3	23c04d1fba0c1733ccd0e4378fae2edde4fd0a7b
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT2_L6_FEZF2\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NDP KIAA1217 TNIP3	3.92e-04	168	38	3	217770a94ace446cdfc7687b459dece707576e76
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT2_L6_FEZF2\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NDP KIAA1217 TNIP3	3.99e-04	169	38	3	0c341f91dc21aaf92bead18d59684d11510502ce
ToppCell	5'-Adult-SmallIntestine-Hematopoietic-T_cells-SELL+_CD8_T\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CARS1 ITPRIP GPR132	3.99e-04	169	38	3	cc1b60eb50a274ffd72c67082c19e43af775e949
ToppCell	343B-Myeloid-Dendritic-cDC_activated\|Dendritic / Donor, Lineage, Cell class and subclass (all cells)	L1TD1 LIMCH1 ENOX1	3.99e-04	169	38	3	e68e6c24606fd46eca6f86bb63fa86ea17879ae2
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D231\|Adult / Lineage, Cell type, age group and donor	LIMCH1 PLCL1 KIAA1217	4.06e-04	170	38	3	269dee5abca9f6aa079f116f0d8f1d198604d9d4
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	LIMCH1 PLCL1 KIAA1217	4.06e-04	170	38	3	a2c738e441ced90eeeb1fcc6ca3269b918aaa298
ToppCell	PND14-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	THSD7B LTBP4 PROX1	4.13e-04	171	38	3	686f95892c3909973c66c9a27159a070a068f175
ToppCell	PND14-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	THSD7B LTBP4 PROX1	4.13e-04	171	38	3	f7ba03e7bdb687f93782c936c7b3374cc5b3b77c
ToppCell	PND14-Endothelial-Endothelial_lymphatic\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	THSD7B LTBP4 PROX1	4.13e-04	171	38	3	d0ac50071a3854d02113c455fcc940a6ec59bbb9
ToppCell	droplet-Lung-1m-Hematologic-myeloid-myeloid_dendritic_cell-myeloid_dendritic_type_1\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	GPR132 TNIP3 TCEAL5	4.13e-04	171	38	3	38a05b5ec8ef8f09a2399994c6b4b9a707918ec1
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_ADARB2_DISP2\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	THSD7B FAM83C PROX1	4.13e-04	171	38	3	4e8460d821aabf26f6a3a5957b22d561113e107f
ToppCell	PND14-Endothelial-Endothelial_lymphatic-Lymphatic_EC\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	THSD7B LTBP4 PROX1	4.13e-04	171	38	3	fbf8e9db00573adcada4b25730e191417b7c9999
ToppCell	facs-Heart-LV-3m-Endothelial-endothelial_cell_of_endocardium\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LDHD MAS1 PROX1	4.20e-04	172	38	3	f2c17c49b375b28ad47dc6cabda62f1c238023dd
ToppCell	facs-Heart-LV-3m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LDHD MAS1 PROX1	4.20e-04	172	38	3	6ab4f01098dddb789df298ddf97b3c384405ee6c
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_SST_CXCL14\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	THSD7B PROX1 MITF	4.27e-04	173	38	3	0ba64e5385fe714f876002520f8b5202809bf11e
ToppCell	10x3'2.3-week_17-19-Hematopoietic-HSC/MPP_and_pro-eo/baso/mast_precursor\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	SYCP2L FAM83C MITF	4.34e-04	174	38	3	64d13a7a9757e85f4f4af876c687dd18a7efa01a
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT2_L6_FEZF2-Exc_L6_FEZF2_TBCC\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NDP THSD7B TNIP3	4.34e-04	174	38	3	e0de0a14319be1a115e5be05d6f9b562e7b32c4a
ToppCell	NS-moderate-d_0-4-Epithelial-Ionocyte\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	LIMCH1 PLCL1 PROX1	4.41e-04	175	38	3	a1e0a15c69211d6db2edeb101476f0f6e08b90c8
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D122\|Adult / Lineage, Cell type, age group and donor	LIMCH1 PLCL1 KIAA1217	4.49e-04	176	38	3	3fee8a367bb9755aca1b7fcc968b08e51b6e9436
ToppCell	saliva-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	FOXO1 BRMS1L USP24	4.49e-04	176	38	3	dca70f309af24421f8dc708cbd88512814b8e79e
ToppCell	5'-GW_trimst-2-LargeIntestine-Epithelial-mature_enterocytic-Paneth\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	L1TD1 MAS1 PROX1	4.56e-04	177	38	3	3743a7d69db9ac4cad70eb531f7075849f34f16b
ToppCell	PND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC-ASMC_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TCEAL3 ENOX1 TCEAL5	4.56e-04	177	38	3	7ebdcedfe02da6d05bba3d625d8bd4c4ea96e4ad
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Degenerative_Distal_Convoluted_Tubule_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PROX1 MITF USP24	4.56e-04	177	38	3	dc846d0feb94d4c289553cc3ac9dac81d10409cb
ToppCell	10x5'v1-week_14-16-Myeloid_macrophage-stroma-osteoclast\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	NDP IQSEC2 MITF	4.64e-04	178	38	3	a28683690ab8a60eb18f3ef87ea85da4e95b22df
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	LIMCH1 PLCL1 KIAA1217	4.64e-04	178	38	3	f5ed4a6e3eb8056b1be1fb311021710c95bdf888
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_SST_CXCL14\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	THSD7B PROX1 MITF	4.72e-04	179	38	3	c7afbd10072d36a35cd20ae73670d76b9cefd22d
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	LIMCH1 THSD7B USP24	4.72e-04	179	38	3	666072c0e8448dbaec1683d18368ec2502453f90
ToppCell	facs-Large_Intestine-Proximal-18m-Epithelial-enteroendocrine_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TCEAL3 ENOX1 PROX1	4.79e-04	180	38	3	9db9899ca42455310e9b63df523fe6c4780abfb7
ToppCell	COVID-19-kidney-PLVAP+EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	ITPRIP SYCP2L KIAA1217	4.79e-04	180	38	3	493cf8d1a8f2a1ed2672f394a0338b110fd81d88
ToppCell	LV\|World / Chamber and Cluster_Paper	LIMCH1 PLCL1 ENOX1	4.79e-04	180	38	3	5ac6f485a58bb29462fec02dfbe8eb70864eafe3
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PLCL1 PROX1 USP24	4.79e-04	180	38	3	9e09b3dfe344b5d50520711513d389865d73a861
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_SST_CXCL14\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	THSD7B PROX1 MITF	4.79e-04	180	38	3	b6efdb4d319ef6f87f559acd974e5a71b06a2322
ToppCell	COPD-Myeloid-DC_Mature\|World / Disease state, Lineage and Cell class	LIMCH1 ENOX1 GPR132	4.87e-04	181	38	3	675603a401d92cf9fdcd44e211ec899fa86a0d49
ToppCell	RV\|World / Chamber and Cluster_Paper	LIMCH1 PLCL1 ENOX1	4.87e-04	181	38	3	bbe1e6e59d8889bd37d6e8303116cbdcafca7236
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-5_VIP_TOX2\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FOXO1 THSD7B PROX1	4.87e-04	181	38	3	154d5e586cab25155c6d06dfe6ae01203b88e0fb
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PLCL1 LTBP4 MITF	4.95e-04	182	38	3	3dfa9187e9d2bab1d199079d29209c4648220ada
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	LIMCH1 MITF USP24	4.95e-04	182	38	3	5f513bbb7125956eb528e3120de3fd776770a7c3
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PLCL1 ARHGEF3 PROX1	4.95e-04	182	38	3	041bc819e6cf2618bf86bce8dfe2df673f392ba3
Drug	iomeprol	FOXO1 FOXO3 MAS1	7.01e-07	11	38	3	CID000003731
Drug	Tetrahydrozoline hydrochloride [522-48-5]; Up 200; 16.8uM; MCF7; HT_HG-U133A	ABCA2 LTBP4 CIC XAB2 IQSEC2	1.70e-05	194	38	5	6769_UP
Drug	Mecamylamine hydrochloride [826-39-1]; Down 200; 19.6uM; MCF7; HT_HG-U133A	DIAPH1 FOXO1 ABCA2 ARHGEF3 USP24	1.88e-05	198	38	5	7023_DN
Disease	hematocrit	FOXO1 ARHGEF3 ABHD16B LTBP4 MPRIP PROX1 MITF	1.58e-04	1011	35	7	EFO_0004348
Disease	Astigmatism	USP53 PLCL1 THSD7B	4.82e-04	129	35	3	HP_0000483
Disease	neuroticism measurement, cognitive function measurement	FOXO3 PLCL1 THSD7B KIAA1217 PROX1	5.15e-04	566	35	5	EFO_0007660, EFO_0008354

Protein segments in the cluster

Peptide	Gene	Start	Entry
SMDTSEVSLDCERME	ARHGEF3	496	Q9NR81
LADDMMRTDVCVFAA	BZW1	86	Q7L1Q6
EAMTERAEMDEVERF	DIAPH1	281	O60610
VACDGNEIDTMFMDR	ABHD16B	146	Q9H3Z7
RSLCNRDTDMEVEDF	ITPRIP	176	Q8IWB1
EESAMSSDRMDCGRK	MPRIP	246	Q6WCQ1
MEYVMCIDREEESHS	MAS1	166	P04201
CVVDEMDFSSMDLDD	IQSEC2	821	Q5JU85
CDQLEERVSAMEDEM	L1RE1	111	Q9UN81
VCIDEFDKMSDMDRT	MCM3	406	P25205
DLDGMFIERLDCDME	FOXO1	601	Q12778
TDMELLCDLMEASSR	FAM83C	181	Q9BQN1
VARIEFLDEVMMDAC	LDHD	296	Q86WU2
RLSVMEEDQACAMES	ABCA2	956	Q9BZC7
EEDQACAMESRRFEE	ABCA2	961	Q9BZC7
CAMESRRFEETRGME	ABCA2	966	Q9BZC7
CMMDTDDEVRDRATF	COPG2	516	Q9UBF2
DMTRMACVDINECDE	LTBP4	1566	Q8N2S1
SSEMDDEDCERRRME	BRMS1L	46	Q5PSV4
DEDCERRRMECLDEM	BRMS1L	51	Q5PSV4
CVMDDDNEVRDRATF	COPG1	516	Q9Y678
REEEMEMSDDENCDS	ENOX1	396	Q8TC92
DDAESTSMFDMRCEE	LIMCH1	321	Q9UPQ0
TSMFDMRCEEEAAVQ	LIMCH1	326	Q9UPQ0
EDKETCFDMLQMDSR	GPR132	181	Q9UNW8
ECDMESIIRSELMDA	FOXO3	621	O43524
DEHAREMCLRFADME	XAB2	661	Q9HCS7
CDNVDTRTVMEEMRA	CARS1	506	P49589
RPTMSQFDMDRLCDE	PROX1	146	Q92786
STIFEECDEELERMM	KIAA1217	1461	Q5T5P2
SEDMTSDEERMVICE	CIC	431	Q96RK0
LMDDAAECFENMLER	USP53	116	Q70EK8
TDEDEEAEMSRRMSV	PLCL1	556	Q15111
VEFCHEEMRTEMEVL	TNIP3	186	Q96KP6
SRASCMQMDDVIDDI	MITF	216	O75030
DELRTEMDEMRDTFF	SOGA3	371	Q5TF21
EMDEMRDTFFEEDAC	SOGA3	376	Q5TF21
MVEFMSAEDDRCLIT	SYCP2L	446	Q5T4T6
SEEMMRECGDVSRAQ	TCEAL6	136	Q6IPX3
SSEEMMRECGDVSRA	TCEAL5	141	Q5H9L2
SEEMMRECGDVSRAQ	TCEAL3	136	Q969E4
TDSSFIMDSDPRRCM	NDP	26	Q00604
SESDENCRRFMDRCM	USP24	166	Q9UPU5
SCISDDNRSAEMMEC	THSD7B	836	Q9C0I4
MGSMEETLCNIDDRD	L1TD1	171	Q5T7N2