Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionendopeptidase inhibitor activity

GBP5 GBP2 GBP3 COL6A3

1.39e-05180174GO:0004866
GeneOntologyMolecularFunctionpeptidase inhibitor activity

GBP5 GBP2 GBP3 COL6A3

1.61e-05187174GO:0030414
GeneOntologyMolecularFunctionG protein activity

GBP5 GBP2 GBP3

1.62e-0559173GO:0003925
GeneOntologyMolecularFunctionendopeptidase regulator activity

GBP5 GBP2 GBP3 COL6A3

2.14e-05201174GO:0061135
GeneOntologyMolecularFunctionactin binding

MYO1A GBP2 GBP3 PLS3 CTNNAL1

3.79e-05479175GO:0003779
GeneOntologyMolecularFunctionGDP phosphatase activity

GBP2 GBP3

4.48e-0512172GO:0004382
GeneOntologyMolecularFunctionpoly(A)-specific ribonuclease activity

CNOT8 CNOT7

5.29e-0513172GO:0004535
GeneOntologyMolecularFunctionpeptidase regulator activity

GBP5 GBP2 GBP3 COL6A3

5.59e-05257174GO:0061134
GeneOntologyMolecularFunctionnucleoside diphosphate phosphatase activity

GBP2 GBP3

1.28e-0420172GO:0017110
GeneOntologyMolecularFunctionGTPase activity

GBP5 GBP7 GBP2 GBP3

1.67e-04341174GO:0003924
GeneOntologyMolecularFunctionGTP binding

GBP5 GBP7 GBP2 GBP3

2.98e-04397174GO:0005525
GeneOntologyMolecularFunctionspectrin binding

GBP2 GBP3

3.77e-0434172GO:0030507
GeneOntologyMolecularFunctionenzyme inhibitor activity

GBP5 GBP2 GBP3 COL6A3

4.22e-04435174GO:0004857
GeneOntologyMolecularFunctionguanyl ribonucleotide binding

GBP5 GBP7 GBP2 GBP3

4.37e-04439174GO:0032561
GeneOntologyMolecularFunctionguanyl nucleotide binding

GBP5 GBP7 GBP2 GBP3

4.37e-04439174GO:0019001
GeneOntologyMolecularFunction3'-5'-RNA exonuclease activity

CNOT8 CNOT7

4.46e-0437172GO:0000175
GeneOntologyMolecularFunctionprotein homodimerization activity

GBP5 GBP7 GBP2 GBP3 SRR

4.59e-04815175GO:0042803
GeneOntologyMolecularFunctionRNA exonuclease activity, producing 5'-phosphomonoesters

CNOT8 CNOT7

5.22e-0440172GO:0016896
GeneOntologyMolecularFunctionRNA exonuclease activity

CNOT8 CNOT7

6.61e-0445172GO:0004532
GeneOntologyMolecularFunctionlipopolysaccharide binding

GBP2 GBP3

7.52e-0448172GO:0001530
GeneOntologyMolecularFunctionactin filament binding

MYO1A PLS3 CTNNAL1

8.76e-04227173GO:0051015
GeneOntologyMolecularFunctionHsp90 protein binding

GBP2 GBP3

9.87e-0455172GO:0051879
GeneOntologyMolecularFunction3'-5' exonuclease activity

CNOT8 CNOT7

1.21e-0361172GO:0008408
GeneOntologyMolecularFunctionexonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters

CNOT8 CNOT7

1.25e-0362172GO:0016796
GeneOntologyMolecularFunctionmolecular function inhibitor activity

GBP5 GBP2 GBP3 COL6A3

1.37e-03596174GO:0140678
GeneOntologyMolecularFunctioncytoskeletal protein binding

MYO1A GBP2 GBP3 PLS3 CTNNAL1

1.78e-031099175GO:0008092
GeneOntologyMolecularFunctionprotein dimerization activity

GBP5 GBP7 GBP2 GBP3 SRR

2.67e-031205175GO:0046983
GeneOntologyMolecularFunctionexonuclease activity

CNOT8 CNOT7

2.73e-0392172GO:0004527
GeneOntologyMolecularFunctionGDP binding

GBP2 GBP3

3.41e-03103172GO:0019003
GeneOntologyMolecularFunctionribonucleoside triphosphate phosphatase activity

GBP5 GBP7 GBP2 GBP3

3.58e-03775174GO:0017111
GeneOntologyMolecularFunctionpyrophosphatase activity

GBP5 GBP7 GBP2 GBP3

4.75e-03839174GO:0016462
GeneOntologyMolecularFunctionhydrolase activity, acting on acid anhydrides

GBP5 GBP7 GBP2 GBP3

4.77e-03840174GO:0016817
GeneOntologyMolecularFunctionhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

GBP5 GBP7 GBP2 GBP3

4.77e-03840174GO:0016818
GeneOntologyMolecularFunctionRNA nuclease activity

CNOT8 CNOT7

5.86e-03136172GO:0004540
GeneOntologyMolecularFunctioncytokine binding

GBP2 GBP3

7.73e-03157172GO:0019955
GeneOntologyMolecularFunctionheat shock protein binding

GBP2 GBP3

8.31e-03163172GO:0031072
GeneOntologyMolecularFunctionGTPase regulator activity

GBP5 GBP2 GBP3

8.49e-03507173GO:0030695
GeneOntologyMolecularFunctionnucleoside-triphosphatase regulator activity

GBP5 GBP2 GBP3

8.49e-03507173GO:0060589
GeneOntologyMolecularFunctioncalmodulin binding

MYO1A UNC13C

1.60e-02230172GO:0005516
GeneOntologyMolecularFunctionnuclease activity

CNOT8 CNOT7

1.62e-02231172GO:0004518
GeneOntologyMolecularFunctioncalcium ion binding

PLS3 UNC13C SRR

2.41e-02749173GO:0005509
GeneOntologyBiologicalProcesspositive regulation of pyroptotic inflammatory response

GBP5 GBP7 GBP2 GBP3

3.97e-119174GO:0140639
GeneOntologyBiologicalProcesscytolysis in another organism

GBP5 GBP7 GBP2 GBP3

3.97e-119174GO:0051715
GeneOntologyBiologicalProcesscytolysis

GBP5 GBP7 GBP2 GBP3

1.56e-1012174GO:0019835
GeneOntologyBiologicalProcesspositive regulation of AIM2 inflammasome complex assembly

GBP5 GBP2 GBP3

1.86e-094173GO:0140973
GeneOntologyBiologicalProcessregulation of AIM2 inflammasome complex assembly

GBP5 GBP2 GBP3

9.29e-096173GO:0140971
GeneOntologyBiologicalProcessAIM2 inflammasome complex assembly

GBP5 GBP2 GBP3

2.60e-088173GO:0140970
GeneOntologyBiologicalProcesspyroptotic inflammatory response

GBP5 GBP7 GBP2 GBP3

3.47e-0842174GO:0070269
GeneOntologyBiologicalProcessadhesion of symbiont to host

GBP7 GBP2 GBP3

5.26e-0720173GO:0044406
GeneOntologyBiologicalProcesspositive regulation of inflammasome-mediated signaling pathway

GBP5 GBP2 GBP3

1.19e-0626173GO:0141087
GeneOntologyBiologicalProcesscellular response to type II interferon

GBP5 GBP7 GBP2 GBP3

1.99e-06114174GO:0071346
GeneOntologyBiologicalProcessdisruption of cell in another organism

GBP5 GBP7 GBP2 GBP3

3.26e-06129174GO:0141061
GeneOntologyBiologicalProcesskilling of cells of another organism

GBP5 GBP7 GBP2 GBP3

3.26e-06129174GO:0031640
GeneOntologyBiologicalProcessdisruption of anatomical structure in another organism

GBP5 GBP7 GBP2 GBP3

3.58e-06132174GO:0141060
GeneOntologyBiologicalProcessdefense response to protozoan

GBP7 GBP2 GBP3

4.17e-0639173GO:0042832
GeneOntologyBiologicalProcessresponse to type II interferon

GBP5 GBP7 GBP2 GBP3

4.65e-06141174GO:0034341
GeneOntologyBiologicalProcesscellular response to interferon-beta

GBP7 GBP2 GBP3

4.86e-0641173GO:0035458
GeneOntologyBiologicalProcessresponse to protozoan

GBP7 GBP2 GBP3

5.23e-0642173GO:0001562
GeneOntologyBiologicalProcessdefense response to virus

GBP5 GBP7 GBP2 GBP3 CNOT7

6.39e-06342175GO:0051607
GeneOntologyBiologicalProcessregulation of inflammasome-mediated signaling pathway

GBP5 GBP2 GBP3

7.86e-0648173GO:0141085
GeneOntologyBiologicalProcessresponse to interferon-beta

GBP7 GBP2 GBP3

7.86e-0648173GO:0035456
GeneOntologyBiologicalProcessinflammasome-mediated signaling pathway

GBP5 GBP2 GBP3

1.06e-0553173GO:0141084
GeneOntologyBiologicalProcesspositive regulation of inflammatory response

GBP5 GBP7 GBP2 GBP3

1.61e-05193174GO:0050729
GeneOntologyBiologicalProcessresponse to virus

GBP5 GBP7 GBP2 GBP3 CNOT7

1.83e-05425175GO:0009615
GeneOntologyBiologicalProcesspositive regulation of pattern recognition receptor signaling pathway

GBP5 GBP2 GBP3

3.54e-0579173GO:0062208
GeneOntologyBiologicalProcessregulation of innate immune response

GBP5 GBP7 GBP2 GBP3 CNOT7

4.77e-05519175GO:0045088
GeneOntologyBiologicalProcesscell killing

GBP5 GBP7 GBP2 GBP3

9.83e-05307174GO:0001906
GeneOntologyBiologicalProcesscellular response to lipopolysaccharide

GBP5 GBP7 GBP2 GBP3

1.13e-04318174GO:0071222
GeneOntologyBiologicalProcessregulation of response to biotic stimulus

GBP5 GBP7 GBP2 GBP3 CNOT7

1.31e-04643175GO:0002831
GeneOntologyBiologicalProcesscellular response to molecule of bacterial origin

GBP5 GBP7 GBP2 GBP3

1.33e-04332174GO:0071219
GeneOntologyBiologicalProcessactivation of innate immune response

GBP5 GBP7 GBP2 GBP3

1.34e-04333174GO:0002218
GeneOntologyBiologicalProcessregulation of cytoplasmic pattern recognition receptor signaling pathway

GBP5 GBP2 GBP3

1.52e-04129173GO:0039531
GeneOntologyBiologicalProcesscellular response to biotic stimulus

GBP5 GBP7 GBP2 GBP3

1.89e-04364174GO:0071216
GeneOntologyBiologicalProcessdefense response to Gram-positive bacterium

GBP7 GBP2 GBP3

2.38e-04150173GO:0050830
GeneOntologyBiologicalProcessdefense response to bacterium

GBP5 GBP7 GBP2 GBP3

2.85e-04405174GO:0042742
GeneOntologyBiologicalProcesspositive regulation of viral genome replication

GBP7 CNOT7

2.93e-0431172GO:0045070
GeneOntologyBiologicalProcesspositive regulation of innate immune response

GBP5 GBP7 GBP2 GBP3

3.27e-04420174GO:0045089
GeneOntologyBiologicalProcessnuclear-transcribed mRNA poly(A) tail shortening

CNOT8 CNOT7

3.33e-0433172GO:0000289
GeneOntologyBiologicalProcesspositive regulation of response to biotic stimulus

GBP5 GBP7 GBP2 GBP3

4.28e-04451174GO:0002833
GeneOntologyBiologicalProcesscytoplasmic pattern recognition receptor signaling pathway

GBP5 GBP2 GBP3

4.61e-04188173GO:0002753
GeneOntologyBiologicalProcessresponse to lipopolysaccharide

GBP5 GBP7 GBP2 GBP3

4.77e-04464174GO:0032496
GeneOntologyBiologicalProcessregulation of pattern recognition receptor signaling pathway

GBP5 GBP2 GBP3

4.98e-04193173GO:0062207
GeneOntologyBiologicalProcessresponse to molecule of bacterial origin

GBP5 GBP7 GBP2 GBP3

5.90e-04491174GO:0002237
GeneOntologyBiologicalProcessregulation of inflammatory response

GBP5 GBP7 GBP2 GBP3

7.06e-04515174GO:0050727
GeneOntologyBiologicalProcesspositive regulation of protein-containing complex assembly

GBP5 GBP2 GBP3

7.98e-04227173GO:0031334
GeneOntologyBiologicalProcessbiological process involved in interaction with host

GBP7 GBP2 GBP3

8.08e-04228173GO:0051701
GeneOntologyBiologicalProcesscellular response to cytokine stimulus

GBP5 GBP7 GBP2 GBP3 CNOT7

8.65e-04967175GO:0071345
GeneOntologyBiologicalProcessregulation of defense response

GBP5 GBP7 GBP2 GBP3 CNOT7

1.03e-031006175GO:0031347
GeneOntologyBiologicalProcesspositive regulation of defense response

GBP5 GBP7 GBP2 GBP3

1.16e-03589174GO:0031349
GeneOntologyBiologicalProcessnuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

CNOT8 CNOT7

1.29e-0365172GO:0000288
GeneOntologyBiologicalProcessactivation of immune response

GBP5 GBP7 GBP2 GBP3

1.43e-03623174GO:0002253
GeneOntologyBiologicalProcessresponse to cytokine

GBP5 GBP7 GBP2 GBP3 CNOT7

1.44e-031083175GO:0034097
GeneOntologyBiologicalProcessregulation of immune response

GBP5 GBP7 GBP2 GBP3 CNOT7

1.45e-031085175GO:0050776
GeneOntologyBiologicalProcesspositive regulation of viral process

GBP7 CNOT7

1.45e-0369172GO:0048524
GeneOntologyBiologicalProcessinnate immune response

GBP5 GBP7 GBP2 GBP3 CNOT7

1.49e-031092175GO:0045087
GeneOntologyBiologicalProcessresponse to peptide

GBP5 GBP7 GBP2 GBP3 CNOT7

1.54e-031100175GO:1901652
GeneOntologyBiologicalProcesspattern recognition receptor signaling pathway

GBP5 GBP2 GBP3

1.68e-03294173GO:0002221
GeneOntologyBiologicalProcessinnate immune response-activating signaling pathway

GBP5 GBP2 GBP3

1.99e-03312173GO:0002758
GeneOntologyBiologicalProcessregulation of viral genome replication

GBP7 CNOT7

2.51e-0391172GO:0045069
GeneOntologyBiologicalProcesspositive regulation of response to external stimulus

GBP5 GBP7 GBP2 GBP3

2.67e-03738174GO:0032103
GeneOntologyBiologicalProcessbiological process involved in symbiotic interaction

GBP7 GBP2 GBP3

2.78e-03351173GO:0044403
GeneOntologyBiologicalProcesscellular response to lipid

GBP5 GBP7 GBP2 GBP3

2.80e-03748174GO:0071396
GeneOntologyBiologicalProcessdefense response to symbiont

GBP5 GBP7 GBP2 GBP3 CNOT7

3.08e-031286175GO:0140546
GeneOntologyBiologicalProcessprotein targeting

GBP5 GBP2 GBP3

3.30e-03373173GO:0006605
GeneOntologyBiologicalProcessregulation of response to external stimulus

GBP5 GBP7 GBP2 GBP3 CNOT7

3.40e-031316175GO:0032101
GeneOntologyBiologicalProcessmiRNA-mediated gene silencing by mRNA destabilization

CNOT8 CNOT7

3.57e-03109172GO:0035279
GeneOntologyBiologicalProcesspositive regulation of immune response

GBP5 GBP7 GBP2 GBP3

4.34e-03845174GO:0050778
GeneOntologyBiologicalProcessintracellular receptor signaling pathway

GBP5 GBP2 GBP3

4.49e-03416173GO:0030522
GeneOntologyBiologicalProcessdefense response to other organism

GBP5 GBP7 GBP2 GBP3 CNOT7

4.54e-031407175GO:0098542
GeneOntologyBiologicalProcessnuclear-transcribed mRNA catabolic process

CNOT8 CNOT7

5.19e-03132172GO:0000956
GeneOntologyBiologicalProcessviral genome replication

GBP7 CNOT7

5.58e-03137172GO:0019079
GeneOntologyBiologicalProcessresponse to bacterium

GBP5 GBP7 GBP2 GBP3

5.79e-03916174GO:0009617
GeneOntologyBiologicalProcessregulation of protein-containing complex assembly

GBP5 GBP2 GBP3

7.03e-03489173GO:0043254
GeneOntologyBiologicalProcessregulation of viral life cycle

GBP7 CNOT7

7.17e-03156172GO:1903900
GeneOntologyBiologicalProcessinflammatory response

GBP5 GBP7 GBP2 GBP3

9.12e-031043174GO:0006954
GeneOntologyBiologicalProcessimmune response-activating signaling pathway

GBP5 GBP2 GBP3

9.85e-03553173GO:0002757
GeneOntologyBiologicalProcessregulation of viral process

GBP7 CNOT7

1.01e-02186172GO:0050792
GeneOntologyCellularComponenthost cell part

GBP7 GBP2 GBP3

8.92e-096173GO:0033643
GeneOntologyCellularComponenthost intracellular part

GBP7 GBP2 GBP3

8.92e-096173GO:0033646
GeneOntologyCellularComponenthost cell cytoplasm part

GBP7 GBP2 GBP3

8.92e-096173GO:0033655
GeneOntologyCellularComponenthost intracellular region

GBP7 GBP2 GBP3

8.92e-096173GO:0043656
GeneOntologyCellularComponenthost cell cytoplasm

GBP7 GBP2 GBP3

8.92e-096173GO:0030430
GeneOntologyCellularComponentsymbiont-containing vacuole

GBP7 GBP2 GBP3

8.92e-096173GO:0020003
GeneOntologyCellularComponentsymbiont-containing vacuole membrane

GBP7 GBP2 GBP3

8.92e-096173GO:0020005
GeneOntologyCellularComponentsymbiont cell surface

GBP5 GBP2 GBP3

2.50e-088173GO:0106139
GeneOntologyCellularComponentother organism part

GBP5 GBP2 GBP3

3.74e-089173GO:0044217
GeneOntologyCellularComponenthost cellular component

GBP7 GBP2 GBP3

2.02e-0715173GO:0018995
GeneOntologyCellularComponentCCR4-NOT core complex

CNOT8 CNOT7

9.32e-066172GO:0030015
GeneOntologyCellularComponentCCR4-NOT complex

CNOT8 CNOT7

7.42e-0516172GO:0030014
GeneOntologyCellularComponentperinuclear region of cytoplasm

GBP5 GBP7 GBP2 GBP3 COPS3

6.95e-04934175GO:0048471
GeneOntologyCellularComponentactin cytoskeleton

MYO1A GBP2 GBP3 PLS3

1.02e-03576174GO:0015629
GeneOntologyCellularComponentP-body

CNOT8 CNOT7

3.06e-03102172GO:0000932
GeneOntologyCellularComponentvesicle membrane

GBP5 GBP7 GBP2 GBP3 UNC13C

3.31e-031325175GO:0012506
GeneOntologyCellularComponentneuromuscular junction

PLS3 UNC13C

3.67e-03112172GO:0031594
GeneOntologyCellularComponentactin filament

MYO1A PLS3

6.15e-03146172GO:0005884
MousePhenoincreased susceptibility to parasitic infection induced morbidity/mortality

GBP2 GBP3

7.61e-0511172MP:0010750
DomainGBP_C

GBP5 GBP7 GBP2 GBP3

9.83e-1110174PF02841
DomainGuanylate-bd_C

GBP5 GBP7 GBP2 GBP3

1.54e-1011174IPR003191
DomainGBP

GBP5 GBP7 GBP2 GBP3

1.54e-1011174PF02263
DomainG_GB1_RHD3_dom

GBP5 GBP7 GBP2 GBP3

1.54e-1011174IPR030386
DomainGuanylate-bd_N

GBP5 GBP7 GBP2 GBP3

1.54e-1011174IPR015894
DomainG_GB1_RHD3

GBP5 GBP7 GBP2 GBP3

1.54e-1011174PS51715
DomainRNase_CAF1

CNOT8 CNOT7

7.79e-065172IPR006941
DomainCAF1

CNOT8 CNOT7

7.79e-065172PF04857
DomainP-loop_NTPase

MYO1A GBP5 GBP7 GBP2 GBP3

7.47e-04848175IPR027417
Domain-

CNOT8 CNOT7

8.23e-04471723.30.420.10
DomainRNaseH-like_dom

CNOT8 CNOT7

1.76e-0369172IPR012337
Domain-

GBP5 GBP7 GBP2 GBP3

3.96e-037461743.40.50.300
PathwayREACTOME_INTERFERON_GAMMA_SIGNALING

GBP5 GBP7 GBP2 GBP3

1.50e-0698134M965
PathwayREACTOME_INTERFERON_SIGNALING

GBP5 GBP7 GBP2 GBP3

8.57e-05273134M983
PathwayREACTOME_TP53_REGULATES_TRANSCRIPTION_OF_ADDITIONAL_CELL_CYCLE_GENES_WHOSE_EXACT_ROLE_IN_THE_P53_PATHWAY_REMAIN_UNCERTAIN

CNOT8 CNOT7

1.19e-0418132MM15336
PathwayREACTOME_TP53_REGULATES_TRANSCRIPTION_OF_ADDITIONAL_CELL_CYCLE_GENES_WHOSE_EXACT_ROLE_IN_THE_P53_PATHWAY_REMAIN_UNCERTAIN

CNOT8 CNOT7

1.63e-0421132M27634
PathwayREACTOME_DEADENYLATION_OF_MRNA

CNOT8 CNOT7

2.14e-0424132MM15090
PathwayREACTOME_DEADENYLATION_OF_MRNA

CNOT8 CNOT7

2.33e-0425132M13492
PathwayREACTOME_M_DECAY_DEGRADATION_OF_MATERNAL_MRNAS_BY_MATERNALLY_STORED_FACTORS

CNOT8 CNOT7

4.08e-0433132M48026
PathwayREACTOME_TP53_REGULATES_TRANSCRIPTION_OF_CELL_CYCLE_GENES

CNOT8 CNOT7

4.33e-0434132MM15325
PathwayREACTOME_TP53_REGULATES_TRANSCRIPTION_OF_CELL_CYCLE_GENES

CNOT8 CNOT7

9.01e-0449132M27614
PathwayREACTOME_DEADENYLATION_DEPENDENT_MRNA_DECAY

CNOT8 CNOT7

1.09e-0354132MM15089
PathwayREACTOME_DEADENYLATION_DEPENDENT_MRNA_DECAY

CNOT8 CNOT7

1.18e-0356132M839
PathwayKEGG_RNA_DEGRADATION

CNOT8 CNOT7

1.30e-0359132M963
Pubmed

In silico genomic analysis of the human and murine guanylate-binding protein (GBP) gene clusters.

GBP5 GBP7 GBP2 GBP3

2.73e-12817416689661
Pubmed

Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases.

GBP5 GBP7 GBP2 GBP3

4.91e-12917424739961
Pubmed

Guanylate binding proteins promote caspase-11-dependent pyroptosis in response to cytoplasmic LPS.

GBP5 GBP7 GBP2 GBP3

1.29e-111117424715728
Pubmed

Extensive characterization of IFN-induced GTPases mGBP1 to mGBP10 involved in host defense.

GBP5 GBP7 GBP2 GBP3

1.29e-111117418025219
Pubmed

Pathogen-selective killing by guanylate-binding proteins as a molecular mechanism leading to inflammasome signaling.

GBP5 GBP7 GBP2 GBP3

1.93e-111217435906252
Pubmed

A family of IFN-γ-inducible 65-kD GTPases protects against bacterial infection.

GBP5 GBP7 GBP2 GBP3

1.51e-101917421551061
Pubmed

Guanylate-binding protein-5 is involved in inflammasome activation by bacterial DNA but only the cooperation of multiple GBPs accounts for control of Brucella abortus infection.

GBP5 GBP2 GBP3

3.88e-10417338404575
Pubmed

Essential Role of mGBP7 for Survival of Toxoplasma gondii Infection.

GBP7 GBP2 GBP3

9.69e-10517331964735
Pubmed

Intracellular trafficking of guanylate-binding proteins is regulated by heterodimerization in a hierarchical manner.

GBP5 GBP2 GBP3

9.69e-10517321151871
Pubmed

Murine GBP-5, a new member of the murine guanylate-binding protein family, is coordinately regulated with other GBPs in vivo and in vitro.

GBP5 GBP2 GBP3

9.69e-10517312396730
Pubmed

Unique features of different members of the human guanylate-binding protein family.

GBP5 GBP2 GBP3

9.69e-10517317266443
Pubmed

Osteoclast fusion and bone loss are restricted by interferon inducible guanylate binding proteins.

GBP5 GBP2 GBP3

8.13e-09917333479228
Pubmed

IRGB10 Liberates Bacterial Ligands for Sensing by the AIM2 and Caspase-11-NLRP3 Inflammasomes.

GBP5 GBP2 GBP3

1.60e-081117327693356
Pubmed

LPS targets host guanylate-binding proteins to the bacterial outer membrane for non-canonical inflammasome activation.

GBP5 GBP2 GBP3

2.13e-081217329459437
Pubmed

Mapping of quantitative trait loci determining NK cell-mediated resistance to MHC class I-deficient bone marrow grafts in perforin-deficient mice.

GBP5 GBP2 GBP3

4.40e-081517317114464
Pubmed

Guanylate-binding proteins promote activation of the AIM2 inflammasome during infection with Francisella novicida.

GBP5 GBP2 GBP3

4.40e-081517325774716
Pubmed

The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection.

GBP5 GBP2 GBP3

6.57e-081717325774715
Pubmed

Interferon inducible GBPs restrict Burkholderia thailandensis motility induced cell-cell fusion.

GBP5 GBP2 GBP3

1.10e-072017332150572
Pubmed

An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome.

GBP7 GBP2 GBP3

1.28e-072117319158679
Pubmed

Interferon-γ primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway.

GBP5 GBP2 GBP3

2.22e-072517335139355
Pubmed

The Ccr4-NOT deadenylase subunits CNOT7 and CNOT8 have overlapping roles and modulate cell proliferation.

CNOT8 CNOT7

2.25e-07217219605561
Pubmed

Genetic Regulation of Guanylate-Binding Proteins 2b and 5 during Leishmaniasis in Mice.

GBP5 GBP2

2.25e-07217229467757
Pubmed

Conservation of the deadenylase activity of proteins of the Caf1 family in human.

CNOT8 CNOT7

2.25e-07217215769875
Pubmed

CNOT7 Outcompetes Its Paralog CNOT8 for Integration into The CCR4-NOT Complex.

CNOT8 CNOT7

2.25e-07217235248544
Pubmed

Structural basis for GTP-induced dimerization and antiviral function of guanylate-binding proteins.

GBP5 GBP2

2.25e-07217233876762
Pubmed

Guanylate binding proteins facilitate caspase-11-dependent pyroptosis in response to type 3 secretion system-negative Pseudomonas aeruginosa.

GBP2 GBP3

6.74e-07317230062052
Pubmed

Domain motions, dimerization, and membrane interactions of the murine guanylate binding protein 2.

GBP2 GBP3

6.74e-07317236639389
Pubmed

Guanylate-Binding Proteins 2 and 5 Exert Broad Antiviral Activity by Inhibiting Furin-Mediated Processing of Viral Envelope Proteins.

GBP5 GBP2

6.74e-07317231091448
Pubmed

The interferon (IFN)-induced GTPase, mGBP-2. Role in IFN-gamma-induced murine fibroblast proliferation.

GBP2 GBP3

6.74e-07317211726669
Pubmed

GTPase properties of the interferon-induced human guanylate-binding protein 2.

GBP2 GBP3

6.74e-0731728706832
Pubmed

The enzyme activities of Caf1 and Ccr4 are both required for deadenylation by the human Ccr4-Not nuclease module.

CNOT8 CNOT7

6.74e-07317225944446
Pubmed

CCR4-NOT deadenylates mRNA associated with RNA-induced silencing complexes in human cells.

CNOT8 CNOT7

6.74e-07317220065043
Pubmed

GBP2 inhibits pathological angiogenesis in the retina via the AKT/mTOR/VEGFA axis.

GBP2 GBP3

6.74e-07317238636926
Pubmed

The interferon-induced GTPase, mGBP-2, confers resistance to paclitaxel-induced cytotoxicity without inhibiting multinucleation.

GBP2 GBP3

6.74e-07317216914101
Pubmed

The CCR4-NOT complex suppresses untimely translational activation of maternal mRNAs.

CNOT8 CNOT7

6.74e-07317237767629
Pubmed

Inhibition of VSV and EMCV replication by the interferon-induced GTPase, mGBP-2: differential requirement for wild-type GTP binding domain.

GBP2 GBP3

6.74e-07317215717119
Pubmed

Guanylate binding proteins contained in the murine chromosome 3 are important to control mycobacterial infection.

GBP2 GBP3

6.74e-07317232620042
Pubmed

[Guanylate-binding protein 2 regulates the maturation of mouse dendritic cells induced by β-glucan].

GBP2 GBP3

6.74e-07317229089068
Pubmed

GBP3 promotes glioblastoma resistance to temozolomide by enhancing DNA damage repair.

GBP7 GBP3

6.74e-07317235780181
Pubmed

Guanylate binding proteins enable rapid activation of canonical and noncanonical inflammasomes in Chlamydia-infected macrophages.

GBP2 GBP3

6.74e-07317226416908
Pubmed

Frequent loss of BTG1 activity and impaired interactions with the Caf1 subunit of the Ccr4-Not deadenylase in non-Hodgkin lymphoma.

CNOT8 CNOT7

6.74e-07317233021411
Pubmed

Subtyping of microsatellite stability colorectal cancer reveals guanylate binding protein 2 (GBP2) as a potential immunotherapeutic target.

GBP2 GBP3

6.74e-07317235383115
Pubmed

Murine guanylate binding protein 2 (mGBP2) controls Toxoplasma gondii replication.

GBP2 GBP3

6.74e-07317223248289
Pubmed

GBP3 promotes glioma cell proliferation via SQSTM1/p62-ERK1/2 axis.

GBP7 GBP3

6.74e-07317229128363
Pubmed

Interferon-induced guanylate-binding proteins lack an N(T)KXD consensus motif and bind GMP in addition to GDP and GTP.

GBP2 GBP3

6.74e-0731721715024
Pubmed

The BTG4 and CAF1 complex prevents the spontaneous activation of eggs by deadenylating maternal mRNAs.

CNOT8 CNOT7

6.74e-07317227605379
Pubmed

Guanylate-binding protein 2 orchestrates innate immune responses against murine norovirus and is antagonized by the viral protein NS7.

GBP2 GBP3

6.74e-07317232354743
Pubmed

Role of GTP binding, isoprenylation, and the C-terminal α-helices in the inhibition of cell spreading by the interferon-induced GTPase, mouse guanylate-binding protein-2.

GBP2 GBP3

6.74e-07317220950129
Pubmed

Two families of GTPases dominate the complex cellular response to IFN-gamma.

GBP2 GBP3

6.74e-0731729862701
Pubmed

The GTPase activity of murine guanylate-binding protein 2 (mGBP2) controls the intracellular localization and recruitment to the parasitophorous vacuole of Toxoplasma gondii.

GBP2 GBP3

6.74e-07317222730319
Pubmed

Interferon regulatory factor 1 is required for mouse Gbp gene activation by gamma interferon.

GBP2 GBP3

1.35e-0641727823961
Pubmed

Genomic organization and chromosomal localization of a new member of the murine interferon-induced guanylate-binding protein family.

GBP2 GBP3

1.35e-06417210386861
Pubmed

Relationships of the antiproliferative proteins BTG1 and BTG2 with CAF1, the human homolog of a component of the yeast CCR4 transcriptional complex: involvement in estrogen receptor alpha signaling pathway.

CNOT8 CNOT7

1.35e-06417211136725
Pubmed

Human carbon catabolite repressor protein (CCR4)-associative factor 1: cloning, expression and characterization of its interaction with the B-cell translocation protein BTG1.

CNOT8 CNOT7

1.35e-0641729820826
Pubmed

Identification of four families of yCCR4- and Mg2+-dependent endonuclease-related proteins in higher eukaryotes, and characterization of orthologs of yCCR4 with a conserved leucine-rich repeat essential for hCAF1/hPOP2 binding.

CNOT8 CNOT7

1.35e-06417211747467
Pubmed

Quantitative characterization of Tob interactions provides the thermodynamic basis for translation termination-coupled deadenylase regulation.

CNOT8 CNOT7

1.35e-06417220595394
Pubmed

Dnmt1/Tet2-mediated changes in Cmip methylation regulate the development of nonalcoholic fatty liver disease by controlling the Gbp2-Pparγ-CD36 axis.

GBP2 GBP3

1.35e-06417236609599
Pubmed

The Furin Protease Dependence and Antiviral GBP2 Sensitivity of Murine Leukemia Virus Infection Are Determined by the Amino Acid Sequence at the Envelope Glycoprotein Cleavage Site.

GBP2 GBP3

1.35e-06417239337476
Pubmed

cDNA for the beta 1 subunit of guanyl nucleotide-binding regulatory proteins from mouse adrenal glands.

GBP2 GBP3

1.35e-0641728917111
Pubmed

The anti-proliferative activity of BTG/TOB proteins is mediated via the Caf1a (CNOT7) and Caf1b (CNOT8) deadenylase subunits of the Ccr4-not complex.

CNOT8 CNOT7

1.35e-06417223236473
Pubmed

The structural basis for the interaction between the CAF1 nuclease and the NOT1 scaffold of the human CCR4-NOT deadenylase complex.

CNOT8 CNOT7

2.25e-06517222977175
Pubmed

TCR Affinity Biases Th Cell Differentiation by Regulating CD25, Eef1e1, and Gbp2.

GBP2 GBP3

2.25e-06517230858199
Pubmed

Cnot8 eliminates naïve regulation networks and is essential for naïve-to-formative pluripotency transition.

CNOT8 CNOT7

2.25e-06517235390160
Pubmed

Anti-proliferative protein Tob negatively regulates CPEB3 target by recruiting Caf1 deadenylase.

CNOT8 CNOT7

2.25e-06517221336257
Pubmed

Murine GBP-2: a new IFN-gamma-induced member of the GBP family of GTPases isolated from macrophages.

GBP2 GBP3

2.25e-0651729858320
Pubmed

Essential functions of the CNOT7/8 catalytic subunits of the CCR4-NOT complex in mRNA regulation and cell viability.

CNOT8 CNOT7

3.37e-06617231924127
Pubmed

Distinct modes of action applied by transcription factors STAT1 and IRF1 to initiate transcription of the IFN-gamma-inducible gbp2 gene.

GBP2 GBP3

3.37e-06617217293456
Pubmed

Immunity-related GTPase M (IRGM) proteins influence the localization of guanylate-binding protein 2 (GBP2) by modulating macroautophagy.

GBP2 GBP3

3.37e-06617221757726
Pubmed

MAPKAP kinase 2 blocks tristetraprolin-directed mRNA decay by inhibiting CAF1 deadenylase recruitment.

CNOT8 CNOT7

3.37e-06617220595389
Pubmed

hCAF1, a new regulator of PRMT1-dependent arginine methylation.

CNOT8 CNOT7

3.37e-06617217264152
Pubmed

CNOT7/hCAF1 is involved in ICAM-1 and IL-8 regulation by tristetraprolin.

CNOT8 CNOT7

3.37e-06617225038453
Pubmed

Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits.

CNOT8 CNOT7

4.72e-06717210637334
Pubmed

TRIF signaling is required for caspase-11-dependent immune responses and lethality in sepsis.

GBP2 GBP3

4.72e-06717230587103
Pubmed

The interferon-gamma-induced GTPase, mGBP-2, inhibits tumor necrosis factor alpha (TNF-alpha) induction of matrix metalloproteinase-9 (MMP-9) by inhibiting NF-kappaB and Rac protein.

GBP2 GBP3

4.72e-06717221502320
Pubmed

The interferon-gamma-induced murine guanylate-binding protein-2 inhibits rac activation during cell spreading on fibronectin and after platelet-derived growth factor treatment: role for phosphatidylinositol 3-kinase.

GBP2 GBP3

4.72e-06717220505078
Pubmed

Phosphorylation of tristetraprolin by MK2 impairs AU-rich element mRNA decay by preventing deadenylase recruitment.

CNOT8 CNOT7

8.08e-06917221078877
Pubmed

Distinct expression patterns of the subunits of the CCR4-NOT deadenylase complex during neural development.

CNOT8 CNOT7

8.08e-06917221741365
Pubmed

Gβ2 Regulates the Multipolar-Bipolar Transition of Newborn Neurons in the Developing Neocortex.

GBP2 GBP3

1.01e-051017228334111
Pubmed

Depletion of mammalian CCR4b deadenylase triggers elevation of the p27Kip1 mRNA level and impairs cell growth.

CNOT8 CNOT7

1.48e-051217217452450
Pubmed

Human Ccr4-Not complexes contain variable deadenylase subunits.

CNOT8 CNOT7

1.48e-051217219558367
Pubmed

Reconstitution of recombinant human CCR4-NOT reveals molecular insights into regulated deadenylation.

CNOT8 CNOT7

1.48e-051217231320642
Pubmed

Human Pat1b connects deadenylation with mRNA decapping and controls the assembly of processing bodies.

CNOT8 CNOT7

2.04e-051417220584987
Pubmed

GW182 proteins directly recruit cytoplasmic deadenylase complexes to miRNA targets.

CNOT8 CNOT7

2.35e-051517221981923
Pubmed

The macrophage IRF8/IRF1 regulome is required for protection against infections and is associated with chronic inflammation.

GBP2 GBP3

3.42e-051817227001747
Pubmed

RNF219 attenuates global mRNA decay through inhibition of CCR4-NOT complex-mediated deadenylation.

CNOT8 CNOT7

4.25e-052017234887419
Pubmed

BTG4 is a meiotic cell cycle-coupled maternal-zygotic-transition licensing factor in oocytes.

CNOT8 CNOT7

6.17e-052417227065194
Pubmed

Impact of lactobacilli on orally acquired listeriosis.

GBP5 GBP2 GBP3

6.43e-0516217323012479
Pubmed

Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes.

GBP2 GBP3

9.06e-052917233278357
Pubmed

Cdx2 regulates endo-lysosomal function and epithelial cell polarity.

MYO1A PLS3

1.18e-043317220551175
Pubmed

Postnatal liver functional maturation requires Cnot complex-mediated decay of mRNAs encoding cell cycle and immature liver genes.

CNOT8 CNOT7

2.01e-044317230733279
Pubmed

Roquin promotes constitutive mRNA decay via a conserved class of stem-loop recognition motifs.

CNOT8 CNOT7

2.20e-044517223663784
Pubmed

Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt.

PLS3 COPS3 CNOT8

2.93e-0427117325737280
InteractionGBP1 interactions

GBP5 GBP2 GBP3

5.61e-0642173int:GBP1
InteractionGBP2 interactions

GBP7 GBP2 GBP3

1.20e-0554173int:GBP2
InteractionGBP7 interactions

GBP7 GBP2

1.87e-058172int:GBP7
InteractionGBP3 interactions

GBP2 GBP3

3.00e-0510172int:GBP3
InteractionTOB2 interactions

CNOT8 CNOT7

1.26e-0420172int:TOB2
InteractionNANOS1 interactions

CNOT8 CNOT7

1.26e-0420172int:NANOS1
InteractionFANCD2OS interactions

CNOT8 CNOT7

2.15e-0426172int:FANCD2OS
InteractionNANOS2 interactions

CNOT8 CNOT7

2.15e-0426172int:NANOS2
InteractionTEX13A interactions

CNOT8 CNOT7

2.32e-0427172int:TEX13A
InteractionCPEB1 interactions

GBP5 CNOT8 CNOT7

2.35e-04146173int:CPEB1
InteractionBTG2 interactions

CNOT8 CNOT7

2.68e-0429172int:BTG2
InteractionBTG1 interactions

CNOT8 CNOT7

2.87e-0430172int:BTG1
InteractionUNK interactions

PLS3 COPS3 CNOT8 CNOT7

3.20e-04408174int:UNK
InteractionKLHL4 interactions

COL6A3 COPS3

3.48e-0433172int:KLHL4
InteractionGADD45B interactions

CNOT8 CNOT7

3.92e-0435172int:GADD45B
InteractionPABPN1L interactions

CNOT8 CNOT7

4.62e-0438172int:PABPN1L
InteractionTOB1 interactions

CNOT8 CNOT7

6.21e-0444172int:TOB1
InteractionMMP7 interactions

CNOT8 CNOT7

6.78e-0446172int:MMP7
InteractionANKRD17 interactions

FGF17 CNOT8 CNOT7

8.43e-04226173int:ANKRD17
InteractionCNOT6 interactions

CNOT8 CNOT7

1.00e-0356172int:CNOT6
Cytoband1p22.2

GBP5 GBP7 GBP2 GBP3

2.62e-10281741p22.2
CytobandEnsembl 112 genes in cytogenetic band chr1p22

GBP5 GBP7 GBP2 GBP3

1.75e-07137174chr1p22
GeneFamilyCCR4-NOT transcription complex

CNOT8 CNOT7

1.51e-05111021023
CoexpressionTABULA_MURIS_SENIS_LIMB_MUSCLE_ENDOTHELIAL_CELL_AGEING

GBP5 GBP7 GBP2 GBP3 PLS3

2.84e-08145175MM3744
CoexpressionSEKI_INFLAMMATORY_RESPONSE_LPS_UP

GBP7 GBP2 GBP3

2.32e-0587173MM1253
CoexpressionZEMEK_IMMUNE_CHECKPOINT_BLOCKADE_OVARIAN_CANCER_OVERLAP_UP

GBP7 GBP2 GBP3

3.32e-0598173MM460
CoexpressionZEMEK_IMMUNE_CHECKPOINT_BLOCKADE_OVARIAN_CANCER_RENCA_UP

GBP7 GBP2 GBP3

3.52e-05100173MM458
CoexpressionHOWARD_B_CELL_INACT_MONOV_INFLUENZA_A_INDONESIA_05_2005_H5N1_AGE_18_49YO_1DY_UP

GBP5 GBP2

3.59e-0514172M41166
CoexpressionHE_LIM_SUN_FETAL_LUNG_C2_CXCL9_POS_MACROPHAGE_CELL

GBP5 GBP2 GBP3

7.02e-05126173M45721
CoexpressionRUAN_RESPONSE_TO_TNF_UP

GBP2 GBP3

8.25e-0521172MM651
CoexpressionGREENBAUM_E2A_TARGETS_DN

GBP2 GBP3

9.08e-0522172MM635
CoexpressionICHIBA_GRAFT_VERSUS_HOST_DISEASE_D7_UP

GBP7 GBP2 GBP3

9.20e-05138173MM1047
CoexpressionRUAN_RESPONSE_TO_TNF_TROGLITAZONE_UP

GBP2 GBP3

1.18e-0425172MM672
CoexpressionSALVADOR_MARTIN_PEDIATRIC_TBD_ANTI_TNF_THERAPY_NONRESPONDER_POST_TREATMENT_UP

GBP5 GBP2

1.28e-0426172M41741
CoexpressionTABULA_MURIS_SENIS_LUNG_BRONCHIAL_SMOOTH_MUSCLE_CELL_AGEING

GBP7 GBP2 GBP3

1.32e-04156173MM3763
CoexpressionHOWARD_DENDRITIC_CELL_INACT_MONOV_INFLUENZA_A_INDONESIA_05_2005_H5N1_AGE_18_49YO_1DY_UP

GBP5 GBP2 GBP3

1.40e-04159173M40998
CoexpressionGSE35825_IFNA_VS_IFNG_STIM_MACROPHAGE_UP

GBP5 GBP2 GBP3

1.51e-04163173M8663
CoexpressionGSE7768_OVA_ALONE_VS_OVA_WITH_LPS_IMMUNIZED_MOUSE_WHOLE_SPLEEN_6H_DN

GBP5 GBP2 GBP3

1.70e-04170173M6852
CoexpressionGSE7348_UNSTIM_VS_LPS_STIM_MACROPHAGE_DN

GBP5 GBP3 CNOT7

1.70e-04170173M6846
CoexpressionGSE6259_FLT3L_INDUCED_DEC205_POS_DC_VS_CD8_TCELL_DN

GBP5 GBP2 GBP3

1.83e-04174173M6769
CoexpressionICHIBA_GRAFT_VERSUS_HOST_DISEASE_35D_UP

GBP7 GBP2 GBP3

1.89e-04176173MM1048
CoexpressionGSE34156_UNTREATED_VS_6H_NOD2_LIGAND_TREATED_MONOCYTE_DN

GBP5 GBP2 GBP3

1.92e-04177173M8666
CoexpressionSOBOLEV_PBMC_PANDEMRIX_AGE_18_64YO_7DY_DN

GBP5 GBP2

2.07e-0433172M41194
CoexpressionXIE_ST_HSC_S1PR3_OE_UP

GBP5 GBP2 COL6A3

2.33e-04189173M41755
CoexpressionGSE43863_NAIVE_VS_MEMORY_TH1_CD4_TCELL_D150_LCMV_UP

GBP5 GBP2 UNC13C

2.33e-04189173M9722
CoexpressionGSE18791_CTRL_VS_NEWCASTLE_VIRUS_DC_18H_DN

GBP5 PLS3 ALPK2

2.48e-04193173M4284
CoexpressionGSE14000_UNSTIM_VS_4H_LPS_DC_TRANSLATED_RNA_DN

GBP5 GBP2 PLS3

2.63e-04197173M3338
CoexpressionGSE2706_R848_VS_R848_AND_LPS_8H_STIM_DC_DN

MYO1A GBP5 PLS3

2.63e-04197173M4720
CoexpressionZENG_GU_ICB_CONTROL_METAGENE_14_PRECICTIVE_ICB_RESPONSE

GBP7 GBP2 GBP3

2.67e-04198173MM17083
CoexpressionGSE22025_TGFB1_VS_TGFB1_AND_PROGESTERONE_TREATED_CD4_TCELL_UP

GBP2 COL6A3 PLS3

2.71e-04199173M8380
CoexpressionGSE1460_INTRATHYMIC_T_PROGENITOR_VS_CD4_THYMOCYTE_UP

PLS3 COPS3 CTNNAL1

2.71e-04199173M3439
CoexpressionGSE17721_CTRL_VS_LPS_24H_BMDC_DN

GBP7 PLS3 ALPK2

2.75e-04200173M3704
CoexpressionGSE369_PRE_VS_POST_IL6_INJECTION_IFNG_WT_LIVER_UP

GBP7 GBP2 COL6A3

2.75e-04200173M5979
CoexpressionGSE11961_MEMORY_BCELL_DAY7_VS_GERMINAL_CENTER_BCELL_DAY40_UP

GBP7 GBP2 UNC13C

2.75e-04200173M9358
CoexpressionGSE9037_CTRL_VS_LPS_1H_STIM_IRAK4_KO_BMDM_DN

GBP7 SRR CTNNAL1

2.75e-04200173M5808
CoexpressionZENG_GU_ICB_CONTROL_METAGENE_8_PRECICTIVE_ICB_RESPONSE

GBP5 GBP2 GBP3

2.75e-04200173MM17082
CoexpressionGSE2770_UNTREATED_VS_IL12_TREATED_ACT_CD4_TCELL_6H_UP

GBP7 GBP2 COPS3

2.75e-04200173M6092
CoexpressionGSE22589_HEALTHY_VS_HIV_INFECTED_DC_DN

GBP7 GBP2 CTNNAL1

2.75e-04200173M7807
CoexpressionHARALAMBIEVA_PBMC_M_M_R_II_AGE_11_22YO_VACCINATED_VS_UNVACCINATED_7YR_UP

GBP5 GBP7 GBP2 GBP3 PLS3

2.97e-04973175M41080
CoexpressionZENG_GU_POST_ICB_METAGENE_31

GBP5 GBP7 CNOT8

3.13e-04209173MM17088
CoexpressionHOWARD_T_CELL_INACT_MONOV_INFLUENZA_A_INDONESIA_05_2005_H5N1_AGE_18_49YO_1DY_UP

GBP5 GBP2

3.36e-0442172M41024
CoexpressionHOWARD_MONOCYTE_INACT_MONOV_INFLUENZA_A_INDONESIA_05_2005_H5N1_AGE_18_49YO_1DY_UP

GBP5 GBP2 GBP3

4.19e-04231173M40995
CoexpressionGRAESSMANN_RESPONSE_TO_MC_AND_SERUM_DEPRIVATION_UP

GBP7 GBP2 GBP3

4.41e-04235173MM978
CoexpressionSASAI_RESISTANCE_TO_NEOPLASTIC_TRANSFROMATION

GBP2 GBP3

5.15e-0452172MM1118
CoexpressionDANG_REGULATED_BY_MYC_DN

GBP2 COL6A3 PLS3

5.34e-04251173M2310
CoexpressionMARKEY_RB1_ACUTE_LOF_DN

GBP7 GBP2 GBP3

6.39e-04267173MM1091
CoexpressionDELASERNA_MYOD_TARGETS_DN

GBP2 GBP3

6.63e-0459172MM659
CoexpressionPLASARI_TGFB1_TARGETS_10HR_DN

GBP2 GBP3 CTNNAL1

6.68e-04271173MM1075
CoexpressionJOSEPH_RESPONSE_TO_SODIUM_BUTYRATE_DN

COL6A3 ALPK2

6.85e-0460172M1515
CoexpressionMIKKELSEN_NPC_LCP_WITH_H3K4ME3

GBP2 GBP3

7.32e-0462172MM865
CoexpressionBLANCO_MELO_RESPIRATORY_SYNCYTIAL_VIRUS_INFECTION_A594_CELLS_UP

GBP5 GBP2 GBP3

7.80e-04286173M34008
CoexpressionGRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP

GBP7 GBP2 GBP3 PLS3 SRR

8.57e-041226175MM979
CoexpressionMAHAJAN_RESPONSE_TO_IL1A_DN

PLS3 CTNNAL1

9.32e-0470172M12107
CoexpressionWUNDER_INFLAMMATORY_RESPONSE_AND_CHOLESTEROL_UP

GBP2 GBP3

1.34e-0384172MM1049
CoexpressionCASTELLANO_NRAS_TARGETS_UP

GBP2 GBP3

1.47e-0388172MM1087
CoexpressionFLECHNER_BIOPSY_KIDNEY_TRANSPLANT_REJECTED_VS_OK_UP

GBP2 COL6A3

1.47e-0388172M19695
CoexpressionFLETCHER_PBMC_BCG_10W_INFANT_PPD_STIMULATED_VS_UNSTIMULATED_10W_UP

GBP5 GBP2

1.57e-0391172M41042
CoexpressionAtlasfacebase_RNAseq_e14.5_palate_poster_proximal_ERK2_WT_2500_K3

GBP5 GBP7 COL6A3 HTRA4

3.37e-05240174facebase_RNAseq_e14.5_palate_poster_proximal_ERK2_WT_2500_K3
ToppCellEndothelial-Endothelial-F|Endothelial / shred on cell class and cell subclass (v4)

GBP5 GBP7 GBP2 GBP3

1.19e-071221742cb8bb63c69aed4d4504b9d97219b8707666f950
ToppCellEndothelial-F|World / shred on cell class and cell subclass (v4)

GBP5 GBP7 GBP2 GBP3

2.01e-0713917432d3c5d35e6c4205711c3500d736fd108443e6b4
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Calb2_Pdlim5|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

GBP5 GBP7 UNC13C ALPK2

3.63e-07161174bf70be1de418615b5442ec684552551edaf1f072
ToppCelldroplet-Limb_Muscle-MUSCLE-30m-Endothelial|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GBP5 GBP7 GBP2 GBP3

5.29e-07177174ca5a30b3e7bcfdd8de01ceaf7449735b5cd503af
ToppCelldroplet-Limb_Muscle-MUSCLE-30m-Endothelial-nan|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GBP5 GBP7 GBP2 GBP3

5.29e-07177174f471f7747d6e8db7546899019af9508f48a14f89
ToppCelldroplet-Limb_Muscle-MUSCLE-30m-Endothelial-endothelial_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GBP5 GBP7 GBP2 GBP3

5.29e-07177174cd0684b876c2a7d5fe7e2773e8e25bb61ecbc795
ToppCelldroplet-Limb_Muscle-MUSCLE-30m|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GBP5 GBP7 GBP2 GBP3

5.41e-0717817401dafd19de04eff459253eaa9a35debf8f3deedf
ToppCellfacs-Bladder-nan-24m-Epithelial-bladder_mesenchymal_cell_(Car3+)|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GBP7 GBP2 COL6A3 UNC13C

5.66e-0718017412537d8a569faa69f474284d2c201475722b8ca1
ToppCelldroplet-Trachea-3m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l19|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

GBP5 GBP7 GBP2 GBP3

5.92e-07182174840427d1c23d60482c943ff006b14007ed44d247
ToppCelldroplet-Limb_Muscle-nan-24m-Endothelial-nan|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GBP5 GBP7 GBP2 GBP3

6.59e-071871747abc174a06bf07b5f6efe0a370fbb1c23e0079b3
ToppCelldroplet-Limb_Muscle-nan-24m-Endothelial|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GBP5 GBP7 GBP2 GBP3

6.59e-07187174b0a2e417b4eb9a185033e89c5df3431c11488688
ToppCelldroplet-Limb_Muscle-nan-24m-Endothelial-endothelial_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GBP5 GBP7 GBP2 GBP3

6.59e-07187174f9863428943b695f26bd680e6fc5aeb38ec3422f
ToppCellLeuk-UTI|World / Disease, Lineage and Cell Type

GBP5 GBP7 GBP2 GBP3

7.48e-0719317426119a0b5d7684022fd16b8b73a0ef5a7d70f3d1
ToppCellSepsis-Leuk-UTI|Sepsis / Disease, condition lineage and cell class

GBP5 GBP2 GBP3 COL6A3

8.62e-072001747d92b24c0c888dd46e40b7e3c6c2645c3604f132
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Hpse_Cbln4|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

GBP7 UNC13C ALPK2

1.08e-05115173ac73aa06e617ed791c6ae9e38189bac74188c27b
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Calb2_Necab1|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

GBP5 GBP7 UNC13C

1.42e-05126173a4fc7ac4931d2fc8aa8196a62d809b698937aa9c
ToppCellBronchial_Biopsy-Epithelial-Ciliated_2|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X

GBP5 GBP2 HTRA4

1.56e-0513017304ad0542210e7a8c8d4d9d0bfd83de2629bc3176
ToppCellMyeloid-F|World / shred on cell class and cell subclass (v4)

GBP5 GBP7 GBP2

2.58e-051541736d53eec4aefe54836bbfd314f28f5e9a24c2d833
ToppCellMyeloid-Myeloid-F|Myeloid / shred on cell class and cell subclass (v4)

GBP5 GBP7 GBP2

2.68e-05156173d6317843ae5c5749452889e768c187a9d9e8c7fe
ToppCellsaliva-Severe-critical_progression_d28-40-Myeloid-Granulocytic-Neutrophil-Neu_c5-GSTP1(high)OASL(low)|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

GBP5 GBP3 SRR

3.06e-05163173d005115aa1e1458b51de7eb719794617a4168608
ToppCelldroplet-Trachea-3m-Mesenchymal-fibroblast-fibroblast_of_trachea-|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

GBP7 GBP2 GBP3

3.29e-05167173774f3264318b002d0df5d06d41d645366038d0bf
ToppCellsystemic_lupus_erythematosus-flare-Hematopoietic-Progen-male|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

MYO1A PLS3 CNOT7

3.29e-05167173b89ebd4906f52b1fe6b6540ec9339284e7caddd2
ToppCelldroplet-Marrow-nan-3m-Myeloid-basophil|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GBP5 GBP7 SRR

3.41e-051691735f5bec13208f4c3b6eacbba180c8a6402743b76e
ToppCelldroplet-Trachea-nan-3m-Endothelial-endothelial_cell|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GBP7 GBP2 GBP3

4.39e-0518417376caad53d55fff5acca27bf190a6de7b27437d9f
ToppCelldroplet-Trachea-nan-3m-Endothelial|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GBP7 GBP2 GBP3

4.39e-05184173fa5c3020e75fdde1363393dea97ebd99f1eae9ff
ToppCelldroplet-Trachea-3m-Endothelial-endothelial_cell_of_trachea|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

GBP7 GBP2 GBP3

4.39e-051841731fc1f0a3b4dbb085ebcc3960f67be24a108fe5b9
ToppCelldroplet-Trachea-3m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

GBP7 GBP2 GBP3

4.39e-051841732467207aaea307873ab286f89cfc7668a227a694
ToppCellLPS-IL1RA|World / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

GBP7 GBP3 CTNNAL1

4.39e-05184173c066c2ec4f0f1d6eb183fca5c7bb0cd45c9950dc
ToppCelldroplet-Trachea-nan-3m-Endothelial-nan|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GBP7 GBP2 GBP3

4.39e-051841731d63cb75a89c5f3f3b9ebf7fce8cb0fd4a92b645
ToppCelldroplet-Trachea-3m-Endothelial|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

GBP7 GBP2 GBP3

4.39e-05184173ad520ab6bb776b5303df505b7e1afb22484f18a7
ToppCellsaliva-Severe-critical_progression_d28-40-Myeloid-Macrophage-macrophage,_alveolar-Macro_c2-CCL3L1|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

GBP5 GBP2 GBP3

4.46e-05185173f30fb9d75cdb757b206312992aaf7485bc900f96
ToppCellFetal_29-31_weeks-Mesenchymal-myofibroblast_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

COL6A3 PLS3 UNC13C

4.60e-05187173c104fbfef2d0bef64077ac721edf2379fd59d547
ToppCellT_cells-ISG-high_CD4+_T_cells|World / Immune cells in Kidney/Urine in Lupus Nephritis

GBP5 GBP2 GBP3

4.68e-051881736f8946d4710f6e32c937213f99b790b098b8819c
ToppCellMesenchymal-myofibroblast_cell|World / Lineage, Cell type, age group and donor

COL6A3 PLS3 UNC13C

4.75e-0518917344e37f88137bb249933eb615235b2cf2ae7f3925
ToppCell18-Airway-Mesenchymal-Airway_Smooth_Muscle|Airway / Age, Tissue, Lineage and Cell class

GBP2 COL6A3 PLS3

4.90e-0519117386ce98d2c90c196474b06869de888cf5d1eed196
ToppCell3'-GW_trimst-1.5-SmallIntestine-Mesenchymal-myocytic-myofibroblast_(RSPO2+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GBP2 COL6A3 PLS3

4.90e-0519117389d03c4133dda852a3713c0902a7d67941cf5b21
ToppCellLPS_only-Endothelial-Endothelial-Activated_Alv_Cap|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

GBP7 GBP3 CTNNAL1

4.90e-05191173a7b18bcf27c38ad2353c239ecb309c80f3ef3359
ToppCell3'-Parenchyma_lung-Endothelial-Blood_vessel_EC-capillary_endothelial_cell-EC_general_capillary-EC_general_capillary_L.2.0.2.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

GBP7 GBP2 CTNNAL1

4.98e-051921736c089bde63dd5f16a07c5929fb49df600f0b21ab
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c12-FOXP3|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)

GBP5 GBP2 CTNNAL1

4.98e-05192173694626965faee8b7c4e5bb78d554f62ba8dbc423
ToppCell3'_v3-blood-Lymphocytic_T_CD4-Tregs|blood / Manually curated celltypes from each tissue

GBP5 GBP2 CTNNAL1

5.06e-051931732ffe44edf2b02d11a7c10513692eb697a10f911e
ToppCellfacs-Lung-ENDOMUCIN-18m-Endothelial-Vein_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GBP5 GBP2 CTNNAL1

5.13e-05194173e8102c8811333f04de7280b7d9b6b85cebb815ac
ToppCellfacs-Lung-ENDOMUCIN-18m-Endothelial-vein_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GBP5 GBP2 CTNNAL1

5.13e-051941734b0d63babb8a46ff45731d5f82b29ccaf6c9402d
ToppCellproximal-Hematologic-Natural_Killer_T|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

GBP5 SRR CNOT8

5.21e-051951733944e4800f5d904d4efa401ce8913ec0e0781211
ToppCellproximal-Hematologic-Natural_Killer_T-3|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

GBP5 SRR CNOT8

5.21e-051951734d7c2c4d0130c2d46877ff6dd4584525d8f74daf
ToppCellB_cells-ISG-high_B_cells|B_cells / Immune cells in Kidney/Urine in Lupus Nephritis

GBP5 GBP2 GBP3

5.21e-05195173b64d9e1a8834401b4dc501566546647754ae21fc
ToppCellproximal-3-Hematologic-Natural_Killer_T|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

GBP5 SRR CNOT8

5.21e-0519517393093545bb23d2619ace029a52cffa1f673a0c2a
ToppCellMesenchymal_cells-Fibro/Chondro_p.|World / Lineage and Cell class

COL6A3 PLS3 HTRA4

5.29e-05196173ddc168849e0e97005a111be004463bb72d433853
ToppCellsevere-Myeloid-Neutrophils_2|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

GBP5 GBP2 GBP3

5.37e-05197173c8a90d82170cf20e14aebecddcf7cc0ca56cda87
ToppCellCV-Mild-1|CV / Virus stimulation, Condition and Cluster

GBP5 GBP2 GBP3

5.45e-051981734b078714c49e7befb7b113d72485e712236d35fa
ToppCellCaecum-T_cell-Treg|T_cell / Region, Cell class and subclass

GBP5 GBP2 PLS3

5.45e-0519817390a2a75ca078f7088b8739795a9b396113bcbe23
ToppCellCaecum-(1)_T_cell-(15)_Treg|Caecum / shred on region, Cell_type, and subtype

GBP5 GBP2 PLS3

5.54e-0519917312c22b07a231c9dc548e9dc37e0a60296a4a6273
ToppCellNasal_Brush-Epithelial-Goblet_2|Nasal_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X

GBP5 GBP7 GBP2

5.54e-051991732ac716f887687b5109fb9feced75d5c62646a268
ToppCellCaecum-T_cell-Treg|Caecum / Region, Cell class and subclass

GBP5 GBP2 PLS3

5.54e-05199173ab0b32c077ac26d32a293dcf686af6984980793f
ToppCellParenchymal-NucSeq-Immune_Myeloid-Macrophage_other-Macro_interstitial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

GBP5 GBP2 GBP3

5.54e-05199173841338719d042247966867ac608146395eb8c4d9
ToppCellTracheal-10x5prime-Immune_Myeloid-Macrophage_other-Macro_interstitial|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

GBP5 GBP7 GBP2

5.54e-051991734b6d49b96bfcd6604b082bab620ae03276520885
ToppCellNasal_Brush-Epithelial-Goblet_2|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X

GBP5 GBP7 GBP2

5.54e-05199173aa6f1390283617c7f9aaf91d379024832ea24a9e
ToppCellBrain_organoid-organoid_Tanaka_cellReport-1m-Neuroepithelial|1m / Sample Type, Dataset, Time_group, and Cell type.

GBP2 GBP3 COL6A3

5.62e-05200173fe15fb050852c187f6f17fb4f6172e69fe7d74a4
ToppCellBrain_organoid-organoid_Tanaka_cellReport-1m-Neuroepithelial-Proteoglycan-expressing_cell|1m / Sample Type, Dataset, Time_group, and Cell type.

GBP2 GBP3 COL6A3

5.62e-05200173d0a4c3bf9c5211defb4c1d0b6653833cccbd29ee
ToppCellLPS_only-Endothelial-Endothelial-Activated_Gen_Cap|LPS_only / Treatment groups by lineage, cell group, cell type

GBP7 GBP3 CTNNAL1

5.62e-052001736f531a418ff25b59a543800cf4bce7b72404ce08
ToppCell3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(nasal)-Club_(nasal)_L.0.2.3.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

GBP7 GBP2 GBP3

5.62e-052001730f6620a5baace704518d42fa2f3f90751240f7dd
ToppCellTracheal-NucSeq-Stromal-Fibroblastic-Fibro_perichondrial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

GBP2 COL6A3 PLS3

5.62e-05200173a4ec0e80f5422b91b85264a9bb74568dd577e285
ToppCellLPS_only-Endothelial-Endothelial-Activated_Alv_Cap|LPS_only / Treatment groups by lineage, cell group, cell type

GBP7 GBP3 CTNNAL1

5.62e-05200173edb64556b3fefe3144f73b6efe23b9ffd34091d2
ToppCelldroplet-Bladder-Unstain-18m-Epithelial-nan|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYO1A FGF17

1.15e-044217256bbec86001d43cc2c71d4dcd70b22ea41963fad
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron-L4-L4_IT_VISp_Rspo1|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

GBP5 GBP7

1.83e-0453172c8af66760dac32cdbc0f17d1c004596c847f16f6
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron-L4|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

GBP5 GBP7

1.83e-0453172d55030028f9ac970afb343ef6e1c41ab4bb2ae53
ToppCellStriatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Drd1-Excitatory_Neuron.Gad1Gad2.Drd1-Lypd1_(dSPN,_patch)-|Striatum / BrainAtlas - Mouse McCarroll V32

MYO1A FGF17

2.93e-046717245228b2a1e445ecba32820a282088fd0c4bb2929
ToppCellStriatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Drd1-Excitatory_Neuron.Gad1Gad2.Drd1-Lypd1_(dSPN,_patch)|Striatum / BrainAtlas - Mouse McCarroll V32

MYO1A FGF17

2.93e-04671724fb4381133cfc3a2d5b633eea76c4fc4ef051f08
ToppCellsaliva-Severe-critical_progression_d12-22_no-steroids-Myeloid-Macrophage-macrophage,_alveolar-Macro_c2-CCL3L1|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

GBP5 COL6A3

3.97e-0478172d5e2e2e04e380b265b2530e93cba6f98ad329e4f
ToppCellPosterior_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1-Calb1-Excitatory_Neuron.Sc17a7.Calb1-Lpl-Penk_(Layer_2/3)|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

FGF17 HTRA4

4.49e-0483172b683c8496474b0df0042f596c9b0ea5916a2ab15
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Tac2_Myh4|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

GBP5 UNC13C

7.44e-04107172fc07dd90f280191bd643398eac5c8273651d0925
ToppCellprimary_visual_cortex-Non-neuronal-leptomeningeal_cell-VLMC-VLMC_Spp1_Hs3st6|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

GBP2 ALPK2

7.44e-041071724a18261492371d19b8dbd403e197fdf64ef69392
ToppCellprimary_visual_cortex-Non-neuronal-leptomeningeal_cell-VLMC-VLMC_Osr1_Cd74|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

GBP2 GBP3

8.59e-041151724c7d78a246f1b44846fb959359515ef185530053
ToppCellThalamus|World / BrainAtlas - Mouse McCarroll V32

UNC13C ALPK2

8.74e-041161725ddfb2dd5459ff6d7ae38163a38eae64fda283b7
ToppCellLPS-IL1RA-Endothelial-Mes-Like|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MYO1A CNOT8

8.89e-041171725a23770806b4612bed4ae6fd716abdec7f7f56c6
ToppCellTCGA-Adrenal-Primary_Tumor-Adrenocortical_carcinoma-Usual_Type-2|TCGA-Adrenal / Sample_Type by Project: Shred V9

GBP5 ALPK2

9.50e-04121172a74f530abc7295bed3e73b37ef47fcb04b0dcc6e
ToppCellRV-03._Atrial_Cardiomyocyte|World / Chamber and Cluster_Paper

MYO1A ALPK2

9.66e-041221721cb1dd03b2aaedbe04f3ed907568c3b7f54767b3
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Calb2_Necab1|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

GBP5 GBP7

1.03e-0312617228fbe63f7bc628b32d8e86bf9e80657e776dd1cc
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Hpse_Cbln4|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

UNC13C ALPK2

1.03e-0312617294bd9cfe982b41a3114885173eab55feb0fbbbae
ToppCellBronchial_Biopsy-Epithelial-Ciliated_2|Bronchial_Biopsy / Tissue, Lineage and Cell class of Lung Cells from 10X

GBP5 GBP2

1.05e-03127172508b188ccbe5aa6ec0128c443aedb5a8ea35a6d0
ToppCellPBMC-Severe-Lymphocyte-T/NK-CD4+_T-Treg-Treg_0|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

GBP5 GBP2

1.10e-03130172d47d4ff1263815896470d854d25306eb36919e70
ToppCellPBMC-Severe-Lymphocyte-T/NK-CD4+_T-Treg-Treg_0|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

GBP5 GBP2

1.10e-03130172ad57b210c96caedadc1027b4d7a56b1bc389b137
ToppCellSubstantia_nigra-Endothelial-ENDOTHELIAL_STALK|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

GBP5 GBP3

1.11e-03131172308ddb7fe113eac5dbeb9cb0b688d9e09275ce5e
ToppCellSubstantia_nigra-Endothelial-ENDOTHELIAL_STALK-Flt1_1|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

GBP5 GBP3

1.13e-0313217206e7337de35bd7120655a22b6020604ad004c4e1
ToppCellfacs-Marrow-B-cells-3m-Myeloid-granulocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

UNC13C ACSBG2

1.21e-031371724dcb15de821439011df1bb0bbd7682d674bd725d
ToppCellfacs-Marrow-B-cells-3m-Myeloid-granulocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

UNC13C ACSBG2

1.21e-03137172c05ceeb7b483324604cb3f647d2da2b3786071b1
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell_cycling-Cycling_Connecting_Tubule_Cell_low-phase|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

GBP5 GBP7

1.23e-03138172cd2f4682fcfd0275ce0640150bbb18da839e5c0a
ToppCellhealthy_donor-Lymphocytic-T_cell-CD4+_T_cell_(ISG_high)|healthy_donor / Disease condition, Lineage, Cell class and subclass

GBP7 COL6A3

1.23e-0313817297f5dc17522462133e582b508ad0ef036e656872
ToppCellPBMC-Mild-Lymphocyte-T/NK-CD4+_T-Treg-Treg_1|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

GBP5 GBP2

1.27e-031401729f105687f5749399fd76043fd85da58be30f2caf
ToppCellPBMC-Mild-Lymphocyte-T/NK-CD4+_T-Treg-Treg_1|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

GBP5 GBP2

1.27e-03140172a3be1fb7d2eb44bc123456d03250502938d46d9d
ToppCellsaliva-Severe-critical_progression_d12-22_no-steroids-Myeloid-Granulocytic-Neutrophil-Neu_c4-RSAD2|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

GBP5 GBP2

1.29e-03141172b5e85f89b930a0ec70cc95733c5ab76ac3e9497f
ToppCellMild/Remission-B_naive-5|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

GBP7 HTRA4

1.30e-03142172fc5fc2d2b4b976358b8ce762c1f440b20db84103
ToppCellGlobus_pallidus-Endothelial-ENDOTHELIAL_STALK-Flt1_1|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

GBP5 GBP3

1.34e-031441721c118b22c2ff3a526a5207d6c9d772636ee065fd
ToppCellmild_COVID-19_(asymptomatic)-Treg|World / disease group, cell group and cell class (v2)

GBP7 COL6A3

1.36e-03145172a3b0e1d0ce0caa8b281a146439d6455db64cc3e5
ToppCellICU-SEP-Lymphocyte-T_NK-Treg|ICU-SEP / Disease, Lineage and Cell Type

GBP5 GBP2

1.36e-03145172ee99b58462f955b96d036aa67e343db047d66f64
ToppCell367C-Lymphocytic-CD4_T-cell-Treg_cell_4|367C / Donor, Lineage, Cell class and subclass (all cells)

GBP5 GBP2

1.36e-0314517229422c908d58081e6a748e362a7ac41bf001444c
ToppCellmild_COVID-19_(asymptomatic)-Treg|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)

GBP7 COL6A3

1.36e-031451722d0903009e918500facfd017ff31f2cec1e76131
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c09-GZMK-FOS_l|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)

GBP5 HTRA4

1.40e-0314717248d72b6770cd029dd299676e5d83e6ac62102049
ToppCellMild/Remission-B_naive-5|Mild/Remission / disease group and sub_cluster of B and Plasma cells(res = 0.5)

GBP7 HTRA4

1.42e-031481728b60f9843505660b3c9d5c7792976f902be4b94c
ToppCellGlobus_pallidus-Endothelial-ENDOTHELIAL_STALK|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

GBP5 GBP3

1.43e-03149172d9c47f523c75ddcd6131e45d2ffc24b970932cae
ToppCell390C-Myeloid-Macrophage-SPP1+_Macrophage_3|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

ALPK2 HTRA4

1.43e-0314917213b445c13bb8f31ff0876addd1baf969ae220ea3
DrugAR18

GBP7 GBP2

5.24e-065172CID000114011
Drug6-chloro-6-deoxymannose

GBP7 GBP2

1.88e-059172CID000021090
Drugbeta-hydroxy simvastatin acid

GBP5 GBP2 GBP3

2.54e-0578173ctd:C483161
Drugdidox

GBP7 GBP2 ALPK2

3.06e-0583173CID000003045
Drugaluminum fluoride

GBP7 GBP2 PLS3 CNOT8

3.96e-05268174CID000002124
DrugAC1L22RD

GBP7 GBP2 PLS3

4.03e-0591173CID000065183
Drug(2s,5s)-5-Carboxymethylproline

GBP7 GBP2 COL6A3 PLS3

7.33e-05314174CID000447989
Diseaseheart disease (implicated_via_orthology)

CNOT8 CNOT7

1.92e-0438162DOID:114 (implicated_via_orthology)
Diseaseasthma

MYO1A COL6A3 UNC13C

7.18e-03751163MONDO_0004979
Diseaseaortic measurement

COL6A3 SRR

7.99e-03251162EFO_0020865

Protein segments in the cluster

PeptideGeneStartEntry
NIGFKVNSKKMLGKY

ACSBG2

351

Q5FVE4
NMGLVKQCLSSLYKK

COPS3

291

Q9UNS2
CNKYCKMLGLKSLQN

ALPK2

2121

Q86TB3
KYICMNKRGKLIGKP

FGF17

106

O60258
FRGNMQKKCYGKIKA

MYO1A

731

Q9UBC5
PKLGANMKKLENCNY

PLS3

451

P13797
KSYLMNKLAGKKNGF

GBP2

51

P32456
KSYLMNKLAGKNKGF

GBP3

51

Q9H0R5
KSYLMNKLAGKNKGF

GBP5

51

Q96PP8
KSYLMNKLAGKNKGF

GBP7

51

Q8N8V2
KYLMKSCKNLKGGLQ

CNOT7

196

Q9UIV1
KGKAFSNKKYLGLQM

HTRA4

371

P83105
LCYKLLKKLQMENNG

CTNNAL1

706

Q9UBT7
MKIKTGKALNLGYAL

COL6A3

906

P12111
KYLMKSCKNLKGGLQ

CNOT8

196

Q9UFF9
DCYQSKLKGKLMPNL

SRR

216

Q9GZT4
KLCKGMFTKKLGNTN

UNC13C

16

Q8NB66