Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	transmembrane receptor protein kinase activity	ACVRL1 EPHA2 ROR1 EPHA5	4.74e-05	85	47	4	GO:0019199
GeneOntologyMolecularFunction	Wnt-protein binding	SFRP4 RECK ROR1	6.95e-05	34	47	3	GO:0017147
GeneOntologyMolecularFunction	RNA exonuclease activity, producing 5'-phosphomonoesters	XRN1 DIS3L ANGEL1	1.14e-04	40	47	3	GO:0016896
GeneOntologyMolecularFunction	RNA exonuclease activity	XRN1 DIS3L ANGEL1	1.62e-04	45	47	3	GO:0004532
GeneOntologyMolecularFunction	protein tyrosine kinase activity	PEAK1 EPHA2 ROR1 EPHA5	3.73e-04	145	47	4	GO:0004713
GeneOntologyMolecularFunction	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	XRN1 DIS3L ANGEL1	4.19e-04	62	47	3	GO:0016796
GeneOntologyMolecularFunction	transmembrane receptor protein tyrosine kinase activity	EPHA2 ROR1 EPHA5	4.82e-04	65	47	3	GO:0004714
GeneOntologyMolecularFunction	sodium ion binding	SCN1A SCN2A	4.85e-04	14	47	2	GO:0031402
GeneOntologyMolecularFunction	metalloendopeptidase inhibitor activity	TIMP2 RECK	6.37e-04	16	47	2	GO:0008191
GeneOntologyMolecularFunction	voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	SCN1A SCN2A	7.21e-04	17	47	2	GO:0099508
GeneOntologyMolecularFunction	flippase activity	ATP8A1 ATP10D	7.21e-04	17	47	2	GO:0140327
GeneOntologyMolecularFunction	ephrin receptor activity	EPHA2 EPHA5	9.04e-04	19	47	2	GO:0005003
GeneOntologyMolecularFunction	exonuclease activity	XRN1 DIS3L ANGEL1	1.33e-03	92	47	3	GO:0004527
GeneOntologyMolecularFunction	voltage-gated sodium channel activity	SCN1A SCN2A	1.70e-03	26	47	2	GO:0005248
GeneOntologyMolecularFunction	alkali metal ion binding	SCN1A SCN2A	1.70e-03	26	47	2	GO:0031420
GeneOntologyMolecularFunction	ATPase-coupled intramembrane lipid transporter activity	ATP8A1 ATP10D	1.97e-03	28	47	2	GO:0140326
GeneOntologyMolecularFunction	nucleocytoplasmic carrier activity	RANBP6 CSE1L	2.57e-03	32	47	2	GO:0140142
GeneOntologyMolecularFunction	3'-5'-RNA exonuclease activity	DIS3L ANGEL1	3.43e-03	37	47	2	GO:0000175
GeneOntologyMolecularFunction	lipoprotein particle receptor binding	RELN PICALM	3.80e-03	39	47	2	GO:0070325
GeneOntologyMolecularFunction	RNA nuclease activity	XRN1 DIS3L ANGEL1	4.03e-03	136	47	3	GO:0004540
GeneOntologyMolecularFunction	aminopeptidase activity	DPP9 MMP14	4.60e-03	43	47	2	GO:0004177
GeneOntologyCellularComponent	T-tubule	FER1L5 SCN1A RYR1 SCN2A	2.98e-05	79	47	4	GO:0030315
GeneOntologyCellularComponent	neuronal cell body	XRN1 GDPD5 RELN ACVRL1 TIMP2 PICALM BTD SCN1A EPHA5	8.62e-05	835	47	9	GO:0043025
GeneOntologyCellularComponent	axon	GDPD5 RELN TIMP2 SCN1A DYNC1I1 ACTR10 SCN2A ROR1 EPHA5	1.41e-04	891	47	9	GO:0030424
GeneOntologyCellularComponent	cell body	XRN1 GDPD5 RELN ACVRL1 TIMP2 PICALM BTD SCN1A EPHA5	1.93e-04	929	47	9	GO:0044297
GeneOntologyCellularComponent	phospholipid-translocating ATPase complex	ATP8A1 ATP10D	4.43e-04	14	47	2	GO:1990531
GeneOntologyCellularComponent	voltage-gated sodium channel complex	SCN1A SCN2A	6.59e-04	17	47	2	GO:0001518
GeneOntologyCellularComponent	sarcolemma	FER1L5 SCN1A RYR1 SCN2A	8.69e-04	190	47	4	GO:0042383
GeneOntologyCellularComponent	node of Ranvier	SCN1A SCN2A	9.16e-04	20	47	2	GO:0033268
GeneOntologyCellularComponent	anchoring junction	KEAP1 PEAK1 MMP14 EPHA2 SCN1A SCN2A ALOX15B EPHA5	1.36e-03	976	47	8	GO:0070161
GeneOntologyCellularComponent	transporter complex	ATP8A1 CATSPERG SCN1A ATP10D RYR1 SCN2A	1.39e-03	550	47	6	GO:1990351
GeneOntologyCellularComponent	somatodendritic compartment	XRN1 GDPD5 RELN ACVRL1 TIMP2 PICALM BTD SCN1A EPHA5	1.45e-03	1228	47	9	GO:0036477
GeneOntologyCellularComponent	cation channel complex	CATSPERG SCN1A RYR1 SCN2A	1.90e-03	235	47	4	GO:0034703
GeneOntologyCellularComponent	axon initial segment	SCN1A SCN2A	1.93e-03	29	47	2	GO:0043194
GeneOntologyCellularComponent	sodium channel complex	SCN1A SCN2A	1.93e-03	29	47	2	GO:0034706
GeneOntologyCellularComponent	cell-cell junction	KEAP1 EPHA2 SCN1A SCN2A ALOX15B EPHA5	2.00e-03	591	47	6	GO:0005911
GeneOntologyCellularComponent	focal adhesion	KEAP1 PEAK1 MMP14 EPHA2 ALOX15B	2.74e-03	431	47	5	GO:0005925
GeneOntologyCellularComponent	cell surface	SFRP4 ACVRL1 TIMP2 PICALM EPHA2 PTPRT ROR1 EPHA5	3.07e-03	1111	47	8	GO:0009986
GeneOntologyCellularComponent	cell-substrate junction	KEAP1 PEAK1 MMP14 EPHA2 ALOX15B	3.08e-03	443	47	5	GO:0030055
GeneOntologyCellularComponent	Cul3-RING ubiquitin ligase complex	KEAP1 KLHL21	3.48e-03	39	47	2	GO:0031463
GeneOntologyCellularComponent	perinuclear region of cytoplasm	GDPD5 PICALM DYNC1I1 RYR1 HERC5 EPHA5 ANGEL1	4.59e-03	934	47	7	GO:0048471
GeneOntologyCellularComponent	voltage-gated calcium channel complex	CATSPERG RYR1	4.81e-03	46	47	2	GO:0005891
HumanPheno	Focal automatism seizure	RELN SCN1A SCN2A	5.50e-06	12	16	3	HP:0032898
Domain	Na_trans_cytopl	SCN1A SCN2A	8.85e-05	6	46	2	PF11933
Domain	Na_trans_cytopl	SCN1A SCN2A	8.85e-05	6	46	2	IPR024583
Domain	PROTEIN_KINASE_TYR	PEAK1 EPHA2 ROR1 EPHA5	9.44e-05	97	46	4	PS00109
Domain	Tyr_kinase_AS	PEAK1 EPHA2 ROR1 EPHA5	9.44e-05	97	46	4	IPR008266
Domain	Na_channel_asu	SCN1A SCN2A	2.64e-04	10	46	2	IPR001696
Domain	Na_trans_assoc	SCN1A SCN2A	2.64e-04	10	46	2	IPR010526
Domain	Na_trans_assoc	SCN1A SCN2A	2.64e-04	10	46	2	PF06512
Domain	Pkinase_Tyr	ACVRL1 EPHA2 ROR1 EPHA5	2.83e-04	129	46	4	PF07714
Domain	Ser-Thr/Tyr_kinase_cat_dom	ACVRL1 EPHA2 ROR1 EPHA5	3.66e-04	138	46	4	IPR001245
Domain	Gal_Oxase/kelch_b-propeller	ATRN KEAP1 KLHL21	4.13e-04	59	46	3	IPR011043
Domain	RECEPTOR_TYR_KIN_V_2	EPHA2 EPHA5	5.30e-04	14	46	2	PS00791
Domain	RECEPTOR_TYR_KIN_V_1	EPHA2 EPHA5	5.30e-04	14	46	2	PS00790
Domain	Eph_TM	EPHA2 EPHA5	5.30e-04	14	46	2	IPR027936
Domain	Tyr_kinase_rcpt_V_CS	EPHA2 EPHA5	5.30e-04	14	46	2	IPR001426
Domain	EPH_lbd	EPHA2 EPHA5	5.30e-04	14	46	2	SM00615
Domain	Ephrin_lbd	EPHA2 EPHA5	5.30e-04	14	46	2	PF01404
Domain	P_typ_ATPase_c	ATP8A1 ATP10D	5.30e-04	14	46	2	IPR032630
Domain	P-type_ATPase_N	ATP8A1 ATP10D	5.30e-04	14	46	2	IPR032631
Domain	EphA2_TM	EPHA2 EPHA5	5.30e-04	14	46	2	PF14575
Domain	Tyr_kinase_ephrin_rcpt	EPHA2 EPHA5	5.30e-04	14	46	2	IPR016257
Domain	Ephrin_rcpt_lig-bd_dom	EPHA2 EPHA5	5.30e-04	14	46	2	IPR001090
Domain	EPH_LBD	EPHA2 EPHA5	5.30e-04	14	46	2	PS51550
Domain	P-type_ATPase_IV	ATP8A1 ATP10D	5.30e-04	14	46	2	IPR006539
Domain	PhoLip_ATPase_C	ATP8A1 ATP10D	5.30e-04	14	46	2	PF16212
Domain	PhoLip_ATPase_N	ATP8A1 ATP10D	5.30e-04	14	46	2	PF16209
Domain	Kelch_1	ATRN KEAP1 KLHL21	6.82e-04	70	46	3	PF01344
Domain	Kelch_1	ATRN KEAP1 KLHL21	6.82e-04	70	46	3	IPR006652
Domain	TyrKc	EPHA2 ROR1 EPHA5	1.33e-03	88	46	3	SM00219
Domain	Tyr_kinase_cat_dom	EPHA2 ROR1 EPHA5	1.33e-03	88	46	3	IPR020635
Domain	NTR	SFRP4 TIMP2	1.45e-03	23	46	2	PS50189
Domain	Netrin_domain	SFRP4 TIMP2	1.45e-03	23	46	2	IPR001134
Domain	Frizzled_dom	SFRP4 ROR1	1.58e-03	24	46	2	IPR020067
Domain	FZ	SFRP4 ROR1	1.58e-03	24	46	2	PS50038
Domain	Fz	SFRP4 ROR1	1.58e-03	24	46	2	PF01392
Domain	Ephrin_rec_like	EPHA2 EPHA5	1.72e-03	25	46	2	SM01411
Domain	Tyr-kin_ephrin_A/B_rcpt-like	EPHA2 EPHA5	1.72e-03	25	46	2	IPR011641
Domain	TIMP-like_OB-fold	SFRP4 TIMP2	1.86e-03	26	46	2	IPR008993
Domain	-	KEAP1 KLHL21	2.00e-03	27	46	2	2.130.10.80
Domain	Kinase-like_dom	WDR81 PEAK1 ACVRL1 EPHA2 ROR1 EPHA5	2.03e-03	542	46	6	IPR011009
Domain	Ion_trans_dom	SCN1A RYR1 SCN2A	2.78e-03	114	46	3	IPR005821
Domain	Ion_trans	SCN1A RYR1 SCN2A	2.78e-03	114	46	3	PF00520
Domain	-	ATP8A1 ATP10D	2.81e-03	32	46	2	3.40.1110.10
Domain	-	ATP8A1 ATP10D	2.81e-03	32	46	2	2.70.150.10
Domain	Gal_Oxidase_b-propeller	KEAP1 KLHL21	3.17e-03	34	46	2	IPR015916
Domain	ATPase_P-typ_cyto_domN	ATP8A1 ATP10D	3.35e-03	35	46	2	IPR023299
Domain	P_typ_ATPase	ATP8A1 ATP10D	3.54e-03	36	46	2	IPR001757
Domain	ATPase_P-typ_P_site	ATP8A1 ATP10D	3.54e-03	36	46	2	IPR018303
Domain	ATPASE_E1_E2	ATP8A1 ATP10D	3.54e-03	36	46	2	PS00154
Domain	ATPase_P-typ_transduc_dom_A	ATP8A1 ATP10D	3.74e-03	37	46	2	IPR008250
Domain	E1-E2_ATPase	ATP8A1 ATP10D	3.74e-03	37	46	2	PF00122
Domain	EGF-like_CS	ATRN RELN EPHA2 EPHA5	3.84e-03	261	46	4	IPR013032
Domain	EGF_2	ATRN RELN EPHA2 EPHA5	4.05e-03	265	46	4	PS01186
Domain	BTB-kelch_protein	KEAP1 KLHL21	5.03e-03	43	46	2	IPR017096
Domain	PROTEIN_KINASE_ATP	PEAK1 ACVRL1 EPHA2 ROR1 EPHA5	5.25e-03	459	46	5	PS00107
Domain	Growth_fac_rcpt_	ATRN EPHA2 EPHA5	6.67e-03	156	46	3	IPR009030
Domain	Prot_kinase_dom	PEAK1 ACVRL1 EPHA2 ROR1 EPHA5	6.83e-03	489	46	5	IPR000719
Domain	PROTEIN_KINASE_DOM	PEAK1 ACVRL1 EPHA2 ROR1 EPHA5	7.06e-03	493	46	5	PS50011
Pathway	BIOCARTA_RECK_PATHWAY	MMP14 TIMP2 RECK	1.63e-06	9	39	3	MM1579
Pathway	BIOCARTA_RECK_PATHWAY	MMP14 TIMP2 RECK	1.63e-06	9	39	3	M22068
Pubmed	Downregulation of reversion-inducing cysteine-rich protein with Kazal motifs in malignant melanoma: inverse correlation with membrane-type 1-matrix metalloproteinase and tissue inhibitor of metalloproteinase 2.	MMP14 TIMP2 RECK	2.31e-09	3	47	3	24335752
Pubmed	Association between SCN1A and SCN2A mutations and clinical/EEG features in Chinese patients from epilepsy or severe seizures.	SCN1A SCN2A	1.79e-06	2	47	2	29649454
Pubmed	Immunohistochemical demonstration of EphA2 processing by MT1-MMP in invasive cutaneous squamous cell carcinoma.	MMP14 EPHA2	1.79e-06	2	47	2	27056569
Pubmed	HPV16 oncoproteins induce MMPs/RECK-TIMP-2 imbalance in primary keratinocytes: possible implications in cervical carcinogenesis.	TIMP2 RECK	1.79e-06	2	47	2	22438955
Pubmed	Neuronal death and perinatal lethality in voltage-gated sodium channel alpha(II)-deficient mice.	SCN1A SCN2A	1.79e-06	2	47	2	10827969
Pubmed	Differential role of sodium channels SCN1A and SCN2A gene polymorphisms with epilepsy and multiple drug resistance in the north Indian population.	SCN1A SCN2A	1.79e-06	2	47	2	19694741
Pubmed	Crystal structure of the complex formed by the membrane type 1-matrix metalloproteinase with the tissue inhibitor of metalloproteinases-2, the soluble progelatinase A receptor.	MMP14 TIMP2	1.79e-06	2	47	2	9724659
Pubmed	Expression of the reversion-inducing cysteine-rich protein with Kazal motifs and matrix metalloproteinase-14 in neuroblastoma and the role in tumour metastasis.	MMP14 RECK	1.79e-06	2	47	2	20579139
Pubmed	Ascorbate-induced osteoblast differentiation recruits distinct MMP-inhibitors: RECK and TIMP-2.	TIMP2 RECK	1.79e-06	2	47	2	18989628
Pubmed	TIMP-2 Interaction with MT1-MMP Activates the AKT Pathway and Protects Tumor Cells from Apoptosis.	MMP14 TIMP2	1.79e-06	2	47	2	26331622
Pubmed	Differential expression of two sodium channel subtypes in human brain.	SCN1A SCN2A	1.79e-06	2	47	2	1317301
Pubmed	Tissue inhibitor of metalloproteinase-2 (TIMP-2) binds to the catalytic domain of the cell surface receptor, membrane type 1-matrix metalloproteinase 1 (MT1-MMP).	MMP14 TIMP2	1.79e-06	2	47	2	9422789
Pubmed	A potential key mechanism in ascending aortic aneurysm development: Detection of a linear relationship between MMP-14/TIMP-2 ratio and active MMP-2.	MMP14 TIMP2	1.79e-06	2	47	2	30794673
Pubmed	Effects of SCN1A and SCN2A polymorphisms on responsiveness to valproic acid monotherapy in epileptic children.	SCN1A SCN2A	1.79e-06	2	47	2	33096315
Pubmed	Clinical exome sequencing identifies two novel mutations of the SCN1A and SCN2A genes in Moroccan patients with epilepsy: a case series.	SCN1A SCN2A	1.79e-06	2	47	2	31439038
Pubmed	Detection of a latent soluble form of membrane type 1 matrix metalloprotease bound with tissue inhibitor of matrix metalloproteinases-2 in periprosthetic tissues and fluids from loose arthroplasty endoprostheses.	MMP14 TIMP2	1.79e-06	2	47	2	24112707
Pubmed	Missense mutations in sodium channel SCN1A and SCN2A predispose children to encephalopathy with severe febrile seizures.	SCN1A SCN2A	1.79e-06	2	47	2	26311622
Pubmed	Affinity- and specificity-enhancing mutations are frequent in multispecific interactions between TIMP2 and MMPs.	MMP14 TIMP2	1.79e-06	2	47	2	24710006
Pubmed	Severe epilepsy, retardation, and dysmorphic features with a 2q deletion including SCN1A and SCN2A.	SCN1A SCN2A	1.79e-06	2	47	2	15249644
Pubmed	Proteolysis of EphA2 Converts It from a Tumor Suppressor to an Oncoprotein.	MMP14 EPHA2	1.79e-06	2	47	2	26130649
Pubmed	Bioorthogonal PEGylation Prolongs the Elimination Half-Life of N-TIMP2 While Retaining MMP Inhibition.	MMP14 TIMP2	1.79e-06	2	47	2	35446024
Pubmed	Tissue inhibitor of metalloproteinases-2 binding to membrane-type 1 matrix metalloproteinase induces MAPK activation and cell growth by a non-proteolytic mechanism.	MMP14 TIMP2	1.79e-06	2	47	2	17991754
Pubmed	Expression of RECK and MMPs in Hepatoblastoma and Neuroblastoma and Comparative Analysis on the Tumor Metastasis.	MMP14 RECK	1.79e-06	2	47	2	25987077
Pubmed	Involvement of MT1-MMP and TIMP-2 in human periodontal disease.	MMP14 TIMP2	1.79e-06	2	47	2	20233321
Pubmed	The developmental changes of Na(v)1.1 and Na(v)1.2 expression in the human hippocampus and temporal lobe.	SCN1A SCN2A	1.79e-06	2	47	2	21377452
Pubmed	[Expression of MT1-MMP and RECK protein in human gastric carcinoma].	MMP14 RECK	1.79e-06	2	47	2	22338226
Pubmed	Timp-2 binding with cellular MT1-MMP stimulates invasion-promoting MEK/ERK signaling in cancer cells.	MMP14 TIMP2	1.79e-06	2	47	2	19551841
Pubmed	Substrate choice of membrane-type 1 matrix metalloproteinase is dictated by tissue inhibitor of metalloproteinase-2 levels.	MMP14 TIMP2	1.79e-06	2	47	2	17425593
Pubmed	EphA2 cleavage by MT1-MMP triggers single cancer cell invasion via homotypic cell repulsion.	MMP14 EPHA2	1.79e-06	2	47	2	23629968
Pubmed	SCN1A and SCN2A polymorphisms are associated with response to valproic acid in Chinese epilepsy patients.	SCN1A SCN2A	1.79e-06	2	47	2	30693367
Pubmed	Nav1.2 is expressed in caudal ganglionic eminence-derived disinhibitory interneurons: Mutually exclusive distributions of Nav1.1 and Nav1.2.	SCN1A SCN2A	5.36e-06	3	47	2	28784306
Pubmed	Association of SCN1A, SCN2A, and UGT2B7 Polymorphisms with Responsiveness to Valproic Acid in the Treatment of Epilepsy.	SCN1A SCN2A	5.36e-06	3	47	2	32185219
Pubmed	Sodium channels SCN1A, SCN2A and SCN3A in familial autism.	SCN1A SCN2A	5.36e-06	3	47	2	12610651
Pubmed	Clinical exome sequencing as the first-tier test for diagnosing developmental disorders covering both CNV and SNV: a Chinese cohort.	SCN1A SCN2A	5.36e-06	3	47	2	32005694
Pubmed	[Tissue collagenase MMP-14 and endogenous regulators of its activity in the corpus uteri in squamous cell carcinoma of the cervix].	MMP14 TIMP2	5.36e-06	3	47	2	29265076
Pubmed	MT-MMP, the cell surface activator of proMMP-2 (pro-gelatinase A), is expressed with its substrate in mouse tissue during embryogenesis.	MMP14 TIMP2	5.36e-06	3	47	2	8743942
Pubmed	The reversion-inducing cysteine-rich protein with Kazal motifs (RECK) interacts with membrane type 1 matrix metalloproteinase and CD13/aminopeptidase N and modulates their endocytic pathways.	MMP14 RECK	5.36e-06	3	47	2	17329256
Pubmed	Expression and role of metalloproteinase-2 and endogenous tissue regulator in ameloblastoma.	MMP14 TIMP2	5.36e-06	3	47	2	19709349
Pubmed	SCN1A, SCN2A and SCN3A gene polymorphisms and responsiveness to antiepileptic drugs: a multicenter cohort study and meta-analysis.	SCN1A SCN2A	5.36e-06	3	47	2	23859570
Pubmed	Cloning of murine membrane-type-1-matrix metalloproteinase (MT-1-MMP) and its metanephric developmental regulation with respect to MMP-2 and its inhibitor.	MMP14 TIMP2	5.36e-06	3	47	2	9648071
Pubmed	Activation ratio of MMP-2 and expression of MT1-MMP are correlated in thymic epithelial tumours.	MMP14 TIMP2	5.36e-06	3	47	2	17886098
Pubmed	Multidrug resistance in epilepsy and polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, and SCN3A: correlation among phenotype, genotype, and mRNA expression.	SCN1A SCN2A	5.36e-06	3	47	2	18784617
Pubmed	[The role of matrix metalloproteinases and their tissue inhibitors in oral lichen planus].	MMP14 TIMP2	5.36e-06	3	47	2	17067460
Pubmed	Characterization of 5' untranslated regions of the voltage-gated sodium channels SCN1A, SCN2A, and SCN3A and identification of cis-conserved noncoding sequences.	SCN1A SCN2A	5.36e-06	3	47	2	17544618
Pubmed	The influence of MMP-14, TIMP-2 and MMP-2 expression on breast cancer prognosis.	MMP14 TIMP2	5.36e-06	3	47	2	16776850
Pubmed	Reversion-inducing cysteine-rich protein with Kazal motifs and MT1-MMP promote the formation of robust fibrillin fibers.	MMP14 RECK	5.36e-06	3	47	2	32730638
Pubmed	MT1-MMP and RECK are involved in human CD34+ progenitor cell retention, egress, and mobilization.	MMP14 RECK	5.36e-06	3	47	2	19197139
Pubmed	Over-expression of Eph and ephrin genes in advanced ovarian cancer: ephrin gene expression correlates with shortened survival.	EPHA2 EPHA5	5.36e-06	3	47	2	16737551
Pubmed	Variable patterns of mutation density among NaV1.1, NaV1.2 and NaV1.6 point to channel-specific functional differences associated with childhood epilepsy.	SCN1A SCN2A	5.36e-06	3	47	2	32845893
Pubmed	Expression of two novel eph-related receptor protein tyrosine kinases in mammary gland development and carcinogenesis.	EPHA2 EPHA5	5.36e-06	3	47	2	8152808
Pubmed	NEDD9 depletion leads to MMP14 inactivation by TIMP2 and prevents invasion and metastasis.	MMP14 TIMP2	5.36e-06	3	47	2	24202705
Pubmed	Matrix metalloproteinase-2, membranous type 1 matrix metalloproteinase, and tissue inhibitor of metalloproteinase-2 expression in ectopic and eutopic endometrium.	MMP14 TIMP2	5.36e-06	3	47	2	12372458
Pubmed	Comparison and optimization of in silico algorithms for predicting the pathogenicity of sodium channel variants in epilepsy.	SCN1A SCN2A	5.36e-06	3	47	2	28518218
Pubmed	Gene-to-gene interaction between sodium channel-related genes in determining the risk of antiepileptic drug resistance.	SCN1A SCN2A	5.36e-06	3	47	2	19270815
Pubmed	Norcantharidin enhances TIMP‑2 anti‑vasculogenic mimicry activity for human gallbladder cancers through downregulating MMP‑2 and MT1‑MMP.	MMP14 TIMP2	5.36e-06	3	47	2	25405519
Pubmed	Membrane-type-1 matrix metalloproteinase, matrix metalloproteinase 2, and tissue inhibitor of matrix proteinase 2 in prostate cancer: identification of patients with poor prognosis by immunohistochemistry.	MMP14 TIMP2	5.36e-06	3	47	2	18329693
Pubmed	TIMP2 deficiency accelerates adverse post-myocardial infarction remodeling because of enhanced MT1-MMP activity despite lack of MMP2 activation.	MMP14 TIMP2	5.36e-06	3	47	2	20056917
Pubmed	Association of SCN1A, SCN2A and ABCC2 gene polymorphisms with the response to antiepileptic drugs in Chinese Han patients with epilepsy.	SCN1A SCN2A	5.36e-06	3	47	2	25155934
Pubmed	Reduced sodium current in Purkinje neurons from Nav1.1 mutant mice: implications for ataxia in severe myoclonic epilepsy in infancy.	SCN1A SCN2A	5.36e-06	3	47	2	17928448
Pubmed	Early expression of sodium channel transcripts and sodium current by cajal-retzius cells in the preplate of the embryonic mouse neocortex.	SCN1A SCN2A	5.36e-06	3	47	2	14973256
Pubmed	[Membrane type 1 matrix metalloproteinase (MT1-MMP) and the regulators of its activity as invasive factors in squamous cell cervical carcinomas].	MMP14 TIMP2	5.36e-06	3	47	2	25552509
Pubmed	GDE2-RECK controls ADAM10 α-secretase-mediated cleavage of amyloid precursor protein.	GDPD5 RECK	5.36e-06	3	47	2	33731436
Pubmed	Nav1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation.	SCN1A SCN2A	1.07e-05	4	47	2	17537961
Pubmed	Sodium channel expression and transcript variation in the developing brain of human, Rhesus monkey, and mouse.	SCN1A SCN2A	1.07e-05	4	47	2	35031483
Pubmed	Enhanced plasticity of retinothalamic projections in an ephrin-A2/A5 double mutant.	EPHA2 EPHA5	1.07e-05	4	47	2	11567058
Pubmed	Targeted DNA Sequencing from Autism Spectrum Disorder Brains Implicates Multiple Genetic Mechanisms.	SCN1A SCN2A	1.07e-05	4	47	2	26637798
Pubmed	Abnormal changes in voltage-gated sodium channels subtypes NaV1.1, NaV1.2, NaV1.3, NaV1.6 and CaM/CaMKII pathway in low-grade astrocytoma.	SCN1A SCN2A	1.07e-05	4	47	2	29578003
Pubmed	EMMPRIN-induced MMP-2 activation cascade in human cervical squamous cell carcinoma.	MMP14 TIMP2	1.07e-05	4	47	2	16425263
Pubmed	Neuronal voltage-gated ion channels are genetic modifiers of generalized epilepsy with febrile seizures plus.	SCN1A SCN2A	1.07e-05	4	47	2	21156207
Pubmed	Association of sodium voltage-gated channel genes polymorphisms with epilepsy risk and prognosis in the Saudi population.	SCN1A SCN2A	1.07e-05	4	47	2	35801810
Pubmed	RECK and TIMP-2 mediate inhibition of MMP-2 and MMP-9 by Annona muricata.	TIMP2 RECK	1.07e-05	4	47	2	32661216
Pubmed	Ephrin-A2 and ephrin-A5 guide contralateral targeting but not topographic mapping of ventral cochlear nucleus axons.	EPHA2 EPHA5	1.07e-05	4	47	2	26666565
Pubmed	Use of recombinant inbred strains for studying genetic determinants of responses to alcohol.	SCN1A SCN2A	1.07e-05	4	47	2	8974318
Pubmed	Three brain sodium channel alpha-subunit genes are clustered on the proximal segment of mouse chromosome 2.	SCN1A SCN2A	1.78e-05	5	47	2	1679748
Pubmed	A new sodium channel alpha-subunit gene (Scn9a) from Schwann cells maps to the Scn1a, Scn2a, Scn3a cluster of mouse chromosome 2.	SCN1A SCN2A	1.78e-05	5	47	2	8812438
Pubmed	Gene expression profiling of preplate neurons destined for the subplate: genes involved in transcription, axon extension, neurotransmitter regulation, steroid hormone signaling, and neuronal survival.	RELN RYR1	1.78e-05	5	47	2	19398467
Pubmed	Addition of poly(A) and poly(A)-rich tails during RNA degradation in the cytoplasm of human cells.	XRN1 DIS3L	1.78e-05	5	47	2	20368444
Pubmed	Angiotensin II stimulates cardiac fibroblast migration via the differential regulation of matrixins and RECK.	MMP14 RECK	1.78e-05	5	47	2	24095877
Pubmed	Clinical significance of ephrin (eph)-A1, -A2, -a4, -a5 and -a7 receptors in pancreatic ductal adenocarcinoma.	EPHA2 EPHA5	1.78e-05	5	47	2	19949912
Pubmed	Differential regulation of membrane type 1-matrix metalloproteinase activity by ERK 1/2- and p38 MAPK-modulated tissue inhibitor of metalloproteinases 2 expression controls transforming growth factor-beta1-induced pericellular collagenolysis.	MMP14 TIMP2	1.78e-05	5	47	2	15247230
Pubmed	Activation of a recombinant membrane type 1-matrix metalloproteinase (MT1-MMP) by furin and its interaction with tissue inhibitor of metalloproteinases (TIMP)-2.	MMP14 TIMP2	1.78e-05	5	47	2	8804434
Pubmed	Endothelial cell lumen and vascular guidance tunnel formation requires MT1-MMP-dependent proteolysis in 3-dimensional collagen matrices.	MMP14 TIMP2	1.78e-05	5	47	2	19339693
Pubmed	Case-control association study of polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, SCN3A, SCN1B, and SCN2B and epilepsy.	SCN1A SCN2A	1.78e-05	5	47	2	24337656
Pubmed	Exonuclease hDIS3L2 specifies an exosome-independent 3'-5' degradation pathway of human cytoplasmic mRNA.	XRN1 DIS3L	2.67e-05	6	47	2	23756462
Pubmed	Expression of MMP-2, -7, -9, MT1-MMP and TIMP-1 and -2 has no prognostic relevance in patients with advanced epithelial ovarian cancer.	MMP14 TIMP2	2.67e-05	6	47	2	22200690
Pubmed	Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity.	EPHA2 EPHA5	2.67e-05	6	47	2	7973638
Pubmed	A 'toothache tree' alkylamide inhibits Aδ mechanonociceptors to alleviate mechanical pain.	SCN1A SCN2A	2.67e-05	6	47	2	23652591
Pubmed	Serous and mucinous ovarian tumors express different profiles of MMP-2, -7, -9, MT1-MMP, and TIMP-1 and -2.	MMP14 TIMP2	2.67e-05	6	47	2	19020757
Pubmed	Temporospatial gene expression and protein localization of matrix metalloproteinases and their inhibitors during mouse molar tooth development.	MMP14 TIMP2	2.67e-05	6	47	2	12950084
Pubmed	RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.	XRN1 PEAK1 PICALM EPHA2 ROR1	2.82e-05	263	47	5	34702444
Pubmed	The matrix metalloproteinase-14 (MMP-14) gene is structurally distinct from other MMP genes and is co-expressed with the TIMP-2 gene during mouse embryogenesis.	MMP14 TIMP2	3.74e-05	7	47	2	9325265
Pubmed	Secreted versus membrane-anchored collagenases: relative roles in fibroblast-dependent collagenolysis and invasion.	MMP14 TIMP2	3.74e-05	7	47	2	19542530
Pubmed	Diagnostic yield of genetic testing in epileptic encephalopathy in childhood.	SCN1A SCN2A	3.74e-05	7	47	2	25818041
Pubmed	The membrane-anchored MMP inhibitor RECK is a key regulator of extracellular matrix integrity and angiogenesis.	MMP14 RECK	3.74e-05	7	47	2	11747814
Pubmed	An in situ hybridization study of MMP-2, -9, -13, -14, TIMP-1, and -2 mRNA in fetal mouse mandibular condylar cartilage as compared with limb bud cartilage.	MMP14 TIMP2	3.74e-05	7	47	2	30822518
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	XRN1 RANBP6 BOP1 CSE1L MMP14 PICALM EPHA2 PSMB3	4.39e-05	974	47	8	28675297
Pubmed	Signaling through the EGF receptor controls lung morphogenesis in part by regulating MT1-MMP-mediated activation of gelatinase A/MMP2.	MMP14 TIMP2	4.98e-05	8	47	2	11865039
Pubmed	FK506-binding protein-like and FK506-binding protein 8 regulate dual leucine zipper kinase degradation and neuronal responses to axon injury.	FKBPL TEDC2	4.98e-05	8	47	2	35101451
Pubmed	Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.	CRLS1 MED4 ATP8A1 DIS3L BTD DYNC1I1 RYR1 SCN2A ALOX15B	5.02e-05	1293	47	9	15342556
Pubmed	Expression of the type IV collagenase system during mouse kidney development and tubule segmentation.	MMP14 TIMP2	6.40e-05	9	47	2	11675412
Cytoband	2q24.3	SCN1A SCN2A	1.22e-04	16	47	2	2q24.3
Cytoband	19q13.1	CATSPERG RYR1	1.47e-03	55	47	2	19q13.1
GeneFamily	Sodium voltage-gated channel alpha subunits	SCN1A SCN2A	1.08e-04	9	32	2	1203
GeneFamily	Fibronectin type III domain containing\|Sterile alpha motif domain containing\|EPH receptors	EPHA2 EPHA5	2.73e-04	14	32	2	1095
GeneFamily	ATPase phospholipid transporting	ATP8A1 ATP10D	3.14e-04	15	32	2	1210
GeneFamily	Kelch like\|BTB domain containing	KEAP1 KLHL21	2.50e-03	42	32	2	617
GeneFamily	Fibronectin type III domain containing	EPHA2 PTPRT EPHA5	2.79e-03	160	32	3	555
GeneFamily	Sterile alpha motif domain containing	EPHA2 EPHA5	1.06e-02	88	32	2	760
GeneFamily	WD repeat domain containing	WDR81 BOP1 DYNC1I1	1.09e-02	262	32	3	362
GeneFamily	Basic leucine zipper proteins\|BTB domain containing	KEAP1 KLHL21	2.34e-02	134	32	2	861
Coexpression	BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_B	GINM1 MMP14 TIMP2 PICALM PLBD2 KLHL21 EPHA2 RYR1	5.77e-06	554	47	8	M2244
Coexpression	WANG_SMARCE1_TARGETS_UP	GRB10 HOXB6 TIMP2 BTD ATP10D ROR1	1.38e-05	294	47	6	M1804
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Neuron-Neuron\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	RELN LINGO2 PTPRT DYNC1I1 SCN2A	2.18e-06	200	47	5	2f481e2fd248c02a5aa2e0248c16808df142fed2
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Neuron\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	RELN LINGO2 PTPRT DYNC1I1 SCN2A	2.18e-06	200	47	5	dc674124475edf83908b51a4e1454bc2dc4f06fa
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Neuron-Neuron-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	RELN LINGO2 PTPRT DYNC1I1 SCN2A	2.18e-06	200	47	5	bd4b9f6b37f4a3c960c4149cf0cfd2caf3327d2d
ToppCell	COVID-19-kidney-Technical/muscle_(Mes)\|kidney / Disease (COVID-19 only), tissue and cell type	RELN PTPRT RYR1 EPHA5	2.38e-05	159	47	4	5335cbcdeaf2bbd0268bbfe0e45c8c0d288e640d
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_medulla\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	GDPD5 RELN RECK DYNC1I1	2.69e-05	164	47	4	8f074940afdbda88a4b697a7ddc687e09a4b818b
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_medulla-lymphatic_endothelial_cell_of_renal_medulla\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	GDPD5 RELN RECK DYNC1I1	2.69e-05	164	47	4	a784f47f67a5eda84d58ad7d9400e3978edbb487
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-lymphatic_endothelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	GDPD5 RELN RECK DYNC1I1	2.69e-05	164	47	4	1a1795969673232191425dde84ab24ee6a98143f
ToppCell	COVID-19-Heart-T_cell\|COVID-19 / Disease (COVID-19 only), tissue and cell type	RELN LINGO2 PTPRT RYR1	3.16e-05	171	47	4	b2e753e811a7639956994609f73efcdb62d04f82
ToppCell	PND07-28-samps-Mesenchymal-Myofibroblast-myofibroblast_-_mature_-_C\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	GRB10 HOXB6 MMP14 DYNC1I1	4.30e-05	185	47	4	427176ad9ab8d9511200fb0a132cfd1e835fe35c
ToppCell	droplet-Heart-4Chambers-21m-Endothelial-leukocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HOXB6 RELN ATP8A1 EPHA2	4.30e-05	185	47	4	bb5a4cf93534b9bcd0923f314c389d571e91e7f8
ToppCell	BAL-Severe-Myeloid-cDC-cDC-cDC_10\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	SFRP4 ATP8A1 DYNC1I1 ROR1	5.07e-05	193	47	4	a2194012dfa0174c6160900625c44e0fd04c50e7
ToppCell	BAL-Severe-Myeloid-cDC-cDC-cDC_10\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SFRP4 ATP8A1 DYNC1I1 ROR1	5.07e-05	193	47	4	7426a30ed01e5c8376b3e0ebe0f1057cfee88340
ToppCell	facs-SCAT-Fat-3m-Mesenchymal\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GRB10 SFRP4 MMP14 TIMP2	5.17e-05	194	47	4	14b614f039bc866a1348a2728a68b7d254c7748c
ToppCell	facs-SCAT-Fat-3m-Mesenchymal-mesenchymal_stem_cell_of_adipose\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GRB10 SFRP4 MMP14 TIMP2	5.17e-05	194	47	4	68c7bfead1158641928cc276f599b4a79e06c73c
ToppCell	facs-SCAT-Fat-3m-Mesenchymal-mesenchymal_progenitor\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GRB10 SFRP4 MMP14 TIMP2	5.17e-05	194	47	4	f6aeae6a1e4017e341323fd4784c9e3bae00552b
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LINGO2 PTPRT SCN1A SCN2A	5.27e-05	195	47	4	787e95fb59c40bba784544b662fac37606ae1427
ToppCell	5'-GW_trimst-2-SmallIntestine-Neuronal-neurons_B-Branch_B1_(eMN)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HOXB6 PTPRT DYNC1I1 SCN2A	5.49e-05	197	47	4	5593721407f61fc5bc3f2f8bf8fa2604c4e29565
ToppCell	5'-GW_trimst-2-SmallIntestine-Neuronal-neurons_B\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HOXB6 PTPRT DYNC1I1 SCN2A	5.49e-05	197	47	4	a1ae1aa797762a3768e14434c7e5cd19c595ecb3
ToppCell	PND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	GRB10 MMP14 TIMP2 PICALM	5.60e-05	198	47	4	a4005a49cf6709b543994ceb51ecd5dc46197fa9
ToppCell	TCGA-Bone_and_Soft_Tissue\|World / Sample_Type by Project: Shred V9	TIMP2 RECK ROR1	3.81e-04	134	47	3	9940a710a5d6670244cce5e19f88b4195a59875b
ToppCell	saliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_B-B_cell-B_c04-SOX5-TNFRSF1B\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	GDPD5 HOXB6 RELN	3.89e-04	135	47	3	c7c30b993b3ddac8f1677d5fe47dc2e66d0d26ac
ToppCell	PND01-03-samps-Mesenchymal-Myofibroblast-myofibroblast_-_mature_-_DCN\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	LINGO2 CREB3L4 SCN2A	4.06e-04	137	47	3	a69976938d4e89315ec0be3a332b91ddf3799d65
ToppCell	COVID-19-kidney-Technical/muscle_(EC)\|kidney / Disease (COVID-19 only), tissue and cell type	RELN PTPRT RYR1	4.24e-04	139	47	3	64c35411bbe67acb5010dadc4b0b1be0f8b17737
ToppCell	COVID-19-kidney-Technical/muscle_(PCT)\|kidney / Disease (COVID-19 only), tissue and cell type	RELN PTPRT SCN1A	4.89e-04	146	47	3	c55f1bdb6ac43b4118cb27ea7c879527e1afcbab
ToppCell	COVID-19-kidney-Technical/muscle_(Mes)\|COVID-19 / Disease (COVID-19 only), tissue and cell type	RELN PTPRT EPHA5	5.09e-04	148	47	3	d6ac5972267254651dfbe16bb4e9a62228093cc7
ToppCell	BAL-Mild-Myeloid-cDC-cDC-cDC_4\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	GDPD5 CREB3L4 ALOX15B	5.19e-04	149	47	3	a85a051e0d82430160967e72fa04b55f43e84513
ToppCell	COVID-19-kidney-Technical/muscle_(Imm)\|COVID-19 / Disease (COVID-19 only), tissue and cell type	RELN PTPRT RYR1	5.29e-04	150	47	3	0205318a870e091add66ee4305747dda9f51510d
ToppCell	BAL-Mild-Myeloid-cDC-cDC-cDC_4\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	GDPD5 CREB3L4 ALOX15B	5.29e-04	150	47	3	7a381f5ae94eba5eb60dcbf83416b4eb18c279ea
ToppCell	390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_1.5\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	HOXB6 ALOX15B ROR1	5.60e-04	153	47	3	764fb5e5fa028c137b8ea65dcd5e4ec9b22191e9
ToppCell	droplet-Liver-Hepatocytes-18m-Myeloid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HOXB6 ATP8A1 TIMP2	6.15e-04	158	47	3	d3446fc98eff09c3626b47a2c90d07cd985378b5
ToppCell	droplet-Liver-Hepatocytes-18m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HOXB6 ATP8A1 TIMP2	6.15e-04	158	47	3	df614450e10629dc9115d7365397663e82f9e48f
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW19-Mesenchymal\|GW19 / Sample Type, Dataset, Time_group, and Cell type.	DPP9 CATSPERG RECK	6.27e-04	159	47	3	f34f2729a3872fbb2939e76ad35d7e25f71b8f57
ToppCell	5'-Airway_Nasal-Immune_Myeloid-Myeloid_macrophage-elicited_macrophage-Monocyte-derived_macrophage\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MMP14 PLBD2 ANGEL1	6.27e-04	159	47	3	d9e535cf9a0a2302268f2897b010dcecc6426e41
ToppCell	5'-Airway_Nasal-Immune_Myeloid-Myeloid_macrophage-elicited_macrophage\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MMP14 PLBD2 ANGEL1	6.27e-04	159	47	3	29999c87f5823f734e5cbf8ea8b729ec017db9b3
ToppCell	5'-Airway_Nasal-Immune_Myeloid-Myeloid_macrophage-elicited_macrophage-Monocyte-derived_macrophage-Monocyte-derived_macrophage_L.1.0.1.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MMP14 PLBD2 ANGEL1	6.27e-04	159	47	3	4b840da854390f8285c219314cff4434d7ffcacc
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW19-Mesenchymal-Unfolded_protein_responsible_cell\|GW19 / Sample Type, Dataset, Time_group, and Cell type.	DPP9 CATSPERG RECK	6.27e-04	159	47	3	929ed98f6c2ad14e8d5af5c6f11a5a3d4b388cf7
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Endothelial-blood_vessel_EC-Fetal_venous_EC\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GDPD5 ATP8A1 ACVRL1	6.38e-04	160	47	3	33050dc646762dc7e9dcc4a12c618e1ba1ce5a4d
ToppCell	Hippocampus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	RANBP6 RELN SCN1A	6.50e-04	161	47	3	b81b346309f3facbfbebd91cae4c5b33c7bd24ef
ToppCell	PBMC-Control-Lymphocyte-T/NK-CD4+_T-Treg-Treg_6\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	GDPD5 KLHL21 HERC5	6.61e-04	162	47	3	6ffcf369d954c20ce036aa1d072cee4e205f728e
ToppCell	PBMC-Control-Lymphocyte-T/NK-CD4+_T-Treg-Treg_6\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	GDPD5 KLHL21 HERC5	6.61e-04	162	47	3	bcbf7f80a2a1c80def795e345f16cf16e8b9d03b
ToppCell	COVID-19-kidney-Technical/muscle_(Imm)\|kidney / Disease (COVID-19 only), tissue and cell type	RELN PTPRT RYR1	6.73e-04	163	47	3	19c28ce16a588a7f4a035c32726f6ccd67702b5b
ToppCell	368C-Epithelial_cells-Epithelial-A_(AT2)-\|368C / Donor, Lineage, Cell class and subclass (all cells)	ATP8A1 TEDC2 ALOX15B	6.85e-04	164	47	3	85f53d184fa70e3eb1af655807f32b17ddbfb304
ToppCell	368C-Epithelial_cells-Epithelial-A_(AT2)\|368C / Donor, Lineage, Cell class and subclass (all cells)	ATP8A1 TEDC2 ALOX15B	6.85e-04	164	47	3	144ba070a1ede71684224cc6d4ead3b7e6a7b4c6
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Fibroblasts-MatrixFB_->_Myofibroblast\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MED4 SFRP4 EPHA5	6.98e-04	165	47	3	15fd9d21dccfa80656a6fa3b72286a6a9252d403
ToppCell	PND07-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_prolif\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	RELN EPHA2 SCN1A	6.98e-04	165	47	3	50a8513d8d2630861499393a7f102b35366bad37
ToppCell	droplet-Marrow-BM-30m-Myeloid-granulocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACVRL1 TIMP2 RECK	7.10e-04	166	47	3	019d365df44c3bbd88c1f4bdceb3de0ff76d3e8d
ToppCell	facs-Skin-Anagen-24m-Epithelial-bulge_keratinocyte\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HOXB6 TIMP2 EPHA5	7.22e-04	167	47	3	78909f685ccd1321064eb0887caf9263e0e54879
ToppCell	PND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_prolif\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ACVRL1 TEDC2 DYNC1I1	7.35e-04	168	47	3	32e4d82efaccf336d347e4063253c3635a3ec672
ToppCell	PND01-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	RELN TIMP2 SCN1A	7.48e-04	169	47	3	f077e39e41fffe7672541f5b72b80faaf56c597c
ToppCell	Ionocyte-iono-1\|World / Class top	PEAK1 ROR1 EPHA5	7.48e-04	169	47	3	4b68bcb4b5fc3cd2db23cd4edace7444aa2d605c
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_PAX6-Inh_L1_PAX6_CA4\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RELN TIMP2 ROR1	7.48e-04	169	47	3	f47c4fbdc2a38745ec1b35104b85121c1413875a
ToppCell	PND01-Endothelial-Endothelial_lymphatic-Lymphatic_EC\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	RELN TIMP2 SCN1A	7.61e-04	170	47	3	35e3945d8a540a3e2cec1b559316265aaad023d1
ToppCell	PND01-Endothelial-Endothelial_lymphatic\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	RELN TIMP2 SCN1A	7.61e-04	170	47	3	0ea625abaa25bab93b70b7000e8f90d5c0f9a0fb
ToppCell	PND01-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	RELN TIMP2 SCN1A	7.61e-04	170	47	3	0b5ddc7d452db0a389927a367914f7d257703f7e
ToppCell	367C-Lymphocytic-NK_cells-NK_cell_D\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	RANBP6 LINGO2 PEAK1	7.74e-04	171	47	3	943fbca8a6ac04052a2a85aca7b21a3461cd96f7
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	KLHL21 EPHA2 PTPRT	7.74e-04	171	47	3	1854a777d9eb9d3fc3ed3632332a6f89ce8131da
ToppCell	Endothelial-Endothelial-G\|Endothelial / shred on cell class and cell subclass (v4)	RELN MMP14 TIMP2	7.87e-04	172	47	3	644f8e42ee8d8996f6ae50cdf874559be55509fc
ToppCell	droplet-Thymus-nan-21m-Lymphocytic-B_cell\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WDR81 ATRN PICALM	8.00e-04	173	47	3	0a0cd40bb5f61431fe34758626c8a63ec610a8a5
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ATP8A1 FER1L5 SCN2A	8.00e-04	173	47	3	0c74bdb40e635d906fd180412c23bf7fed61621e
ToppCell	Endothelial-B-Donor_03\|World / lung cells shred on cell class, cell subclass, sample id	RELN RECK DYNC1I1	8.00e-04	173	47	3	a81992965137195d20fc498f750975303961a828
ToppCell	droplet-Marrow-nan-24m-Myeloid-basophil\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GDPD5 CATSPERG PLBD2	8.00e-04	173	47	3	6d2ceba4f89a228600e2b40aba81bb0eb81578c0
ToppCell	10x5'-blood-Mast-Mast_cells\|blood / Manually curated celltypes from each tissue	GRB10 GDPD5 ATP10D	8.13e-04	174	47	3	a5838821bba2be790d32331ff529d466e9974268
ToppCell	droplet-Heart-nan-18m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HOXB6 SFRP4 TIMP2	8.13e-04	174	47	3	cf4e0567f2a4ebe5534046b1c091af59b55bdc4f
ToppCell	10x5'-blood-Mast\|blood / Manually curated celltypes from each tissue	GRB10 GDPD5 ATP10D	8.13e-04	174	47	3	3a8a253213b207e3ff56f94a74996b8d9ad47aa1
ToppCell	facs-Trachea-18m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l20-1\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	HOXB6 SFRP4 SCN2A	8.13e-04	174	47	3	1d157f7a919c8246e83d8060d2a0017c6c781ef3
ToppCell	3'-GW_trimst-2-SmallIntestine-Endothelial-lymphatic_endothelial-LEC3_(ADGRG3+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GDPD5 RELN PLBD2	8.27e-04	175	47	3	43be63976da5ad0764d24d90919a77ce46068f52
ToppCell	P15-Endothelial-lymphatic_endothelial_cell-endothelial_cell_of_lymphatic_vessel\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	RELN MMP14 TIMP2	8.27e-04	175	47	3	84d252f3e432231687613299bbea14978bb4b06b
ToppCell	P15-Endothelial-lymphatic_endothelial_cell\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	RELN MMP14 TIMP2	8.27e-04	175	47	3	a00c6fa9b33640710dd05a3799031147196f0986
ToppCell	PND07-28-samps-Endothelial-Postnatal_endothelial-endothelial_cells_C\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	GRB10 GDPD5 ACVRL1	8.55e-04	177	47	3	6da88c358b3a2e47fa3472217a38b6b00ad7b280
ToppCell	TCGA-Ovary-Primary_Tumor-Ovarian_Carcinoma-Serous_Cystadenocarcinoma-6\|TCGA-Ovary / Sample_Type by Project: Shred V9	SFRP4 MMP14 TIMP2	8.69e-04	178	47	3	142879e9393e721f9b05a6bb46995c9d6d713c95
ToppCell	PSB-critical-LOC-Myeloid-Basophil\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	HOXB6 SFRP4 SCN2A	8.69e-04	178	47	3	45bdbb96094c97756e1b6eebd80eadd8472143f2
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN LINGO2 DYNC1I1	8.83e-04	179	47	3	69a1b3b05c921de6343ffe6ad998aa2b804312a7
ToppCell	BAL-Mild-cDC_4\|Mild / Compartment, Disease Groups and Clusters	GDPD5 CREB3L4 ALOX15B	8.83e-04	179	47	3	68511e87b12b8253de7771e5ccfc5869248b8450
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN LINGO2 DYNC1I1	8.83e-04	179	47	3	479116ac65488c60104a053530830763ec1f95b2
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN LINGO2 DYNC1I1	8.83e-04	179	47	3	1dfc0cb8b369aef35c59f3d4c52603dc9f3728c1
ToppCell	E18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_prolif\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	BOP1 TIMP2 ROR1	8.83e-04	179	47	3	ce3ca7f3a5864e62307aa744a3173f350a90df28
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_PAX6\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RELN TIMP2 ROR1	8.83e-04	179	47	3	0b6731d9554f8bed1899c165a50e6b329ea19a6d
ToppCell	PCW_13-14-Neuronal-Neuronal_postreplicative-neuro_neuronal_(6)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	LINGO2 SCN1A SCN2A	8.83e-04	179	47	3	af0b54c9ea0b6e4210f22dbb6e88ecd3276a5f86
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_119\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FKBPL BOP1 TIMP2	8.83e-04	179	47	3	b70509288aaf4457afd350f6c45784521337ce0d
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN RYR1 SCN2A	8.97e-04	180	47	3	6ac62bf1251978c8c12e715f7b73144fca619794
ToppCell	Control-Epithelial_cells-AT2\|Control / group, cell type (main and fine annotations)	ATP8A1 SCN1A ALOX15B	8.97e-04	180	47	3	198b19e7910b4a8cc7e820c525ab357c7f99f578
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SCN1A DYNC1I1 SCN2A	8.97e-04	180	47	3	f6a2208960d0df1500c974cc44c3c054cd7475a9
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LINGO2 PTPRT EPHA5	9.12e-04	181	47	3	6e8c5460021d3999daec58e3d6661a6fa998fd16
ToppCell	(2)_5-FU-(4)_COL2.3+_osteoblasts\|(2)_5-FU / Stress and Cell class	MMP14 TIMP2 KLHL21	9.12e-04	181	47	3	56ae86072858c156681507aecd1bc6cb0a3372d2
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L3_VIP_CBLN1\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RELN SFRP4 TIMP2	9.12e-04	181	47	3	7846c7b33d1b89364c5a704edaa86520db731c89
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_PAX6\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RELN TIMP2 ROR1	9.26e-04	182	47	3	86a2330ada7637144a67afbf9f3a902901ab1130
ToppCell	Epithelial-lung_neuroendocrine_cell_(PNEC)\|World / Lineage, Cell type, age group and donor	LINGO2 DYNC1I1 SCN2A	9.26e-04	182	47	3	57bf4ffb304324e2e392e196336a530d9f78fe0d
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	GDPD5 RELN PEAK1	9.26e-04	182	47	3	41b070085edba7a58b81c20aa4942d06f745acf8
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	GDPD5 RELN PEAK1	9.26e-04	182	47	3	5e9a67b2de0daa4fdc344b10a857d8a901ad810e
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	GDPD5 RELN PEAK1	9.26e-04	182	47	3	b0fe042c71d6ab8c75abd7ba9d2de00b72d01c0c
ToppCell	Hippocampus-Neuronal-Inhibitory\|Hippocampus / BrainAtlas - Mouse McCarroll V32	RELN SCN1A ALOX15B	9.26e-04	182	47	3	b54ae650c04dfd0759c5f5e752b9bf684dd36516
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LINGO2 PTPRT EPHA5	9.41e-04	183	47	3	274076a0978bce2bd53a1732045f18ef0f2d9985
ToppCell	3'_v3-lymph-node_spleen-Myeloid_Mac-Macrophage\|lymph-node_spleen / Manually curated celltypes from each tissue	HOXB6 ACVRL1 TIMP2	9.41e-04	183	47	3	0bcbd60e10b9d6898915dab1987fd46dc7238b19
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Endothelial-leukocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FKBPL RELN ATP10D	9.41e-04	183	47	3	919c9861073d12fd12aecd7469b1478b13838c43
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN SCN2A EPHA5	9.56e-04	184	47	3	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN SCN2A EPHA5	9.56e-04	184	47	3	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN SCN2A EPHA5	9.56e-04	184	47	3	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Neuronal-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN SFRP4 ATP8A1	9.56e-04	184	47	3	e33bb572af9dfd11127105f1ac99bc958a7cafbb
ToppCell	TCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-4\|TCGA-Pancreas / Sample_Type by Project: Shred V9	RECK ATP10D ROR1	9.56e-04	184	47	3	67164bb6bcae7322cb89b585c7aa10bce35b0ecd
ToppCell	facs-Brain_Non-Myeloid-Cerebellum_-18m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SCN1A DYNC1I1 SCN2A	9.56e-04	184	47	3	7d9bcdaff8cbea4c50ab7db0f8e01f6bbd0ef593
Drug	8(S),15(S)-diHETE	ACVRL1 RYR1 ALOX15B	3.69e-06	15	47	3	CID000001897
Drug	bis(4-hydroxycinnamoyl)methane	KEAP1 MMP14 TIMP2	3.22e-05	30	47	3	ctd:C034786
Drug	Hydroxytacrine maleate (R,S) [118909-22-1]; Down 200; 12.2uM; HL60; HT_HG-U133A	GDPD5 TIMP2 BTD KLHL21 TEDC2	4.89e-05	194	47	5	2430_DN
Drug	Chloropyramine hydrochloride [6170-42-9]; Down 200; 12.2uM; PC3; HT_HG-U133A	CSE1L MMP14 PICALM BTD ATP10D	4.89e-05	194	47	5	4589_DN
Drug	Famotidine [76824-35-6]; Up 200; 11.8uM; PC3; HG-U133A	ATRN GDPD5 ACVRL1 PTPRT TEDC2	5.01e-05	195	47	5	1946_UP
Drug	Bufexamac [2438-72-4]; Up 200; 18uM; HL60; HT_HG-U133A	GDPD5 RELN TIMP2 BTD SCN1A	5.01e-05	195	47	5	2382_UP
Drug	Sulfasalazine [599-79-1]; Down 200; 10uM; MCF7; HT_HG-U133A	ATRN GRB10 BTD ATP10D HERC5	5.14e-05	196	47	5	5446_DN
Drug	Lisuride (S)(-) [18016-80-3]; Down 200; 11.8uM; MCF7; HT_HG-U133A	GRB10 BTD EPHA2 RYR1 HERC5	5.26e-05	197	47	5	1545_DN
Drug	Amiloride hydrochloride dihydrate [17440-83-4]; Down 200; 13.2uM; MCF7; HT_HG-U133A	GRB10 CSE1L TIMP2 BTD EPHA2	5.26e-05	197	47	5	1470_DN
Drug	Piroxicam [36322-90-4]; Down 200; 12uM; MCF7; HT_HG-U133A	GRB10 CSE1L KLHL21 EPHA2 TEDC2	5.39e-05	198	47	5	7445_DN
Drug	Delsoline [509-18-2]; Down 200; 8.6uM; MCF7; HT_HG-U133A	GRB10 GDPD5 CSE1L BTD TEDC2	5.52e-05	199	47	5	7212_DN
Drug	demethoxycurcumin	KEAP1 MMP14 TIMP2	6.61e-05	38	47	3	ctd:C050229
Disease	Marfan syndrome (is_marker_for)	MMP14 TIMP2	1.49e-05	4	47	2	DOID:14323 (is_marker_for)
Disease	Dupuytren Contracture	BOP1 SFRP4 MMP14 TIMP2	2.68e-05	108	47	4	EFO_0004229
Disease	Seizure, Febrile, Simple	SCN1A SCN2A	5.19e-05	7	47	2	C0149886
Disease	Seizure, Febrile, Complex	SCN1A SCN2A	5.19e-05	7	47	2	C0751057
Disease	frozen shoulder	SFRP4 MMP14	5.19e-05	7	47	2	EFO_1000941
Disease	Febrile Convulsions	SCN1A SCN2A	8.88e-05	9	47	2	C0009952
Disease	glycosyl-N-stearoyl-sphingosine (d18:1/18:0) measurement	CREB3L4 ATP10D	8.88e-05	9	47	2	EFO_0800275
Disease	Generalized Epilepsy with Febrile Seizures Plus	SCN1A SCN2A	8.88e-05	9	47	2	C3502809
Disease	hip bone mineral density, hip bone size	HOXB6 LINGO2 TIMP2	9.89e-05	56	47	3	EFO_0004844, EFO_0007702
Disease	generalized epilepsy with febrile seizures plus 2 (implicated_via_orthology)	SCN1A SCN2A	1.11e-04	10	47	2	DOID:0111294 (implicated_via_orthology)
Disease	Kunitz-type protease inhibitor 2 measurement	CATSPERG RYR1	1.11e-04	10	47	2	EFO_0008200
Disease	Dravet syndrome (implicated_via_orthology)	SCN1A SCN2A	1.11e-04	10	47	2	DOID:0080422 (implicated_via_orthology)
Disease	generalized epilepsy with febrile seizures plus (implicated_via_orthology)	SCN1A SCN2A	1.62e-04	12	47	2	DOID:0060170 (implicated_via_orthology)
Disease	Ischemic stroke	LINGO2 SFRP4 PICALM PTPRT PSMB3	1.63e-04	324	47	5	HP_0002140
Disease	Infantile Severe Myoclonic Epilepsy	SCN1A SCN2A	1.92e-04	13	47	2	C0751122
Disease	thoracic aortic aneurysm (is_marker_for)	MMP14 TIMP2	2.23e-04	14	47	2	DOID:14004 (is_marker_for)
Disease	MMR-related febrile seizures	SCN1A SCN2A	2.57e-04	15	47	2	EFO_0006519
Disease	Early infantile epileptic encephalopathy with suppression bursts	SCN1A SCN2A	2.94e-04	16	47	2	C0393706
Disease	Febrile seizure (within the age range of 3 months to 6 years)	SCN1A SCN2A	3.74e-04	18	47	2	HP_0002373
Disease	anxiety disorder (implicated_via_orthology)	SCN1A SCN2A	5.62e-04	22	47	2	DOID:2030 (implicated_via_orthology)
Disease	eyelid sagging measurement	SFRP4 ATP8A1	1.19e-03	32	47	2	EFO_0009360
Disease	Cholestasis, Extrahepatic	KEAP1 TIMP2	1.19e-03	32	47	2	C0005398
Disease	Squamous cell carcinoma of lung	EPHA2 EPHA5	1.19e-03	32	47	2	C0149782

Protein segments in the cluster

Peptide	Gene	Start	Entry
MDDPDYWRTVQDPMT	BOP1	176	Q14137
AEEVCSMSWYTPMPI	CATSPERG	161	Q6ZRH7
MDCPAALYQLMLDCW	EPHA5	901	P54756
CYFMHCPQMEWENPN	BTBD11	471	A6QL63
QMMRECWYPNPSARL	ACVRL1	466	P37023
DWCSLNNPPLEMMFD	ACTR10	386	Q9NZ32
WCIGLYNVMFTAMPP	ATP8A1	891	Q9Y2Q0
MCVTCNPPSNPYWIM	ATP10D	1276	Q9P241
SDPSAIMAPFYQWMD	MMP14	251	P50281
PDYCPETMVEIWNCM	RECK	71	O95980
MYGMCESLWEPNMDP	PSMB3	146	P49720
RAEPPSSYKVMCQWM	GINM1	231	Q9NU53
GQCMEWYTMSTCPPE	ATRN	971	O75882
TCMDWSLQYPELMVA	DYNC1I1	291	O14576
CVMANPTYDIDPNWD	PEAK1	1181	Q9H792
EIDYWPLLDMMPANS	LINGO2	231	Q7L985
MPPDEYCLMWVTADL	GDPD5	491	Q8WTR4
LAPQYPWQSNDMSMN	MED4	216	Q9NPJ6
EKPAFDYPMNQMSVW	RELN	1241	P78509
NEMDTAQFCMQYWPE	PTPRT	1276	O14522
QKCSTPVYPWMQRMN	HOXB6	121	P17509
PVYPWMQRMNSCNSS	HOXB6	126	P17509
FLLPECPMMHISNNW	HERC5	491	Q9UII4
QMPEALQASDLWYCP	FKBPL	86	Q9UIM3
SWEALQPMTYPMDNC	KLHL21	401	Q9UJP4
MVMQCYDPDTDLWSL	KLHL21	436	Q9UJP4
FWASMMEAASCPPDY	DPP9	591	Q86TI2
AQMCEMPVNTPESPW	DIS3L	441	Q8TF46
DCPSAIYQLMMQCWQ	EPHA2	841	P29317
WNVNAPPTFHSEMMY	BTD	386	P43251
YNPMTNQWSPCAPMS	KEAP1	396	Q14145
KNPMNFFPEQMVTWC	GRB10	256	Q13322
DASFMQTLWNMNPIC	RYR1	191	P21817
DQWSPAFMVPDSCMV	CREB3L4	141	Q8TEY5
SLYENPWTIPNMLSM	CRLS1	101	Q9UJA2
FDSCAWMPNLPPSMQ	ALOX15B	561	O15296
SAAPMDWMQEYRCLL	TEDC2	286	Q7L2K0
QCSIRMMDADPKWPY	FER1L5	1851	A0AVI2
DPQTSYMVSAWARMC	RANBP6	606	O60518
NCVFMTMSNPPDWTK	SCN1A	141	P35498
MWAAIPMQSEPQYAD	ANGEL1	146	Q9UNK9
DCPPRMYSLMTECWN	ROR1	716	Q01973
MYSLMTECWNEIPSR	ROR1	721	Q01973
TAWNAATMAPPVMAY	PICALM	586	Q13492
TECPPMMDTEYTKLW	CSE1L	851	P55060
DDCEPLMKMYNHSWP	SFRP4	106	Q6FHJ7
TNCVFMTMSNPPDWT	SCN2A	141	Q99250
MTMSNPPDWTKNVEY	SCN2A	146	Q99250
MIPCYISSPDECLWM	TIMP2	161	P16035
NVQSMDNMCWPAPSQ	XRN1	1421	Q8IZH2
MAQSLDPSYLMCWIG	TTC37	886	Q6PGP7
MQEEMESNPDSPYWH	PLBD2	166	Q8NHP8
WEPHEYPASMERMQN	WDR81	471	Q562E7
YPASMERMQNWTPDE	WDR81	476	Q562E7