Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	alkaline phosphatase activity	ALPI ALPP	1.23e-04	6	58	2	GO:0004035
GeneOntologyBiologicalProcess	establishment of skin barrier	FLG TP63 HRNR FLG2	4.58e-06	41	56	4	GO:0061436
GeneOntologyCellularComponent	keratohyalin granule	FLG HRNR FLG2	2.24e-07	5	60	3	GO:0036457
GeneOntologyCellularComponent	cornified envelope	FLG KLK7 RPTN HRNR FLG2	1.60e-06	69	60	5	GO:0001533
HumanPheno	Short attention span	FLG KANSL1 SETD5 NEXMIF RFX7 SPEN BBS12 FOXG1 WAC	1.02e-04	517	21	9	HP:0000736
HumanPheno	Reduced attention regulation	FLG KANSL1 SETD5 NEXMIF RFX7 SPEN BBS12 FOXG1 WAC	1.17e-04	526	21	9	HP:5200044
HumanPheno	Abnormal size of the palpebral fissures	KANSL1 SETD5 TP63 RFX7 SPEN FOXG1 WAC	1.25e-04	298	21	7	HP:0200007
HumanPheno	Attention deficit hyperactivity disorder	FLG KANSL1 SETD5 NEXMIF RFX7 SPEN FOXG1 WAC	1.38e-04	413	21	8	HP:0007018
HumanPheno	Autistic behavior	FLG KANSL1 SETD5 NEXMIF RFX7 SPEN BBS12 FOXG1 MFF WAC	1.44e-04	678	21	10	HP:0000729
HumanPheno	Abnormality of salivation	SETD5 NEXMIF TP63 IRAK1 SPEN FOXG1	1.68e-04	215	21	6	HP:0100755
Domain	S100_CABP	FLG RPTN HRNR FLG2	1.60e-06	27	60	4	PS00303
Domain	S_100	FLG RPTN HRNR FLG2	1.60e-06	27	60	4	PF01023
Domain	S100_Ca-bd_sub	FLG RPTN HRNR FLG2	1.86e-06	28	60	4	IPR013787
Domain	S100/CaBP-9k_CS	FLG RPTN HRNR FLG2	1.86e-06	28	60	4	IPR001751
Domain	S_100	FLG RPTN HRNR FLG2	1.86e-06	28	60	4	SM01394
Domain	Filaggrin	FLG FLG2	1.01e-05	2	60	2	IPR003303
Domain	SPAR_C	SIPA1L1 SIPA1L3	3.04e-05	3	60	2	PF11881
Domain	SIPA1L_C	SIPA1L1 SIPA1L3	3.04e-05	3	60	2	IPR021818
Domain	Alk_phosphatase	ALPI ALPP	6.06e-05	4	60	2	PF00245
Domain	Alkaline_phosphatase_AS	ALPI ALPP	6.06e-05	4	60	2	IPR018299
Domain	Alkaline_phosphatase	ALPI ALPP	6.06e-05	4	60	2	IPR001952
Domain	alkPPc	ALPI ALPP	6.06e-05	4	60	2	SM00098
Domain	ALKALINE_PHOSPHATASE	ALPI ALPP	6.06e-05	4	60	2	PS00123
Domain	Rap_GAP	SIPA1L1 SIPA1L3	4.49e-04	10	60	2	PF02145
Domain	Rap_GAP_dom	SIPA1L1 SIPA1L3	5.48e-04	11	60	2	IPR000331
Domain	RAPGAP	SIPA1L1 SIPA1L3	5.48e-04	11	60	2	PS50085
Domain	EF_Hand_1_Ca_BS	FLG RPTN HRNR FLG2	2.41e-03	175	60	4	IPR018247
Domain	EF_HAND_1	FLG RPTN HRNR FLG2	4.18e-03	204	60	4	PS00018
Domain	Alkaline_phosphatase_core	ALPI ALPP	4.44e-03	31	60	2	IPR017850
Domain	Alkaline_Pase-like_a/b/a	ALPI ALPP	4.44e-03	31	60	2	IPR017849
Domain	-	ALPI ALPP	4.44e-03	31	60	2	3.40.720.10
Domain	EF_HAND_2	FLG RPTN HRNR FLG2	6.47e-03	231	60	4	PS50222
Domain	EF_hand_dom	FLG RPTN HRNR FLG2	6.57e-03	232	60	4	IPR002048
Pubmed	Defects of filaggrin-like proteins in both lesional and nonlesional atopic skin.	FLG HRNR FLG2	5.66e-09	3	63	3	23403047
Pubmed	Interactomes of Glycogen Synthase Kinase-3 Isoforms.	MTUS1 SIPA1L1 SIPA1L3 ATG2B TNRC6A AKAP11	2.24e-06	209	63	6	36779422
Pubmed	Human placental and intestinal alkaline phosphatase genes map to 2q34-q37.	ALPI ALPP	3.23e-06	2	63	2	3687940
Pubmed	Atopic Dermatitis Susceptibility Variants in Filaggrin Hitchhike Hornerin Selective Sweep.	FLG HRNR	3.23e-06	2	63	2	27678121
Pubmed	Placental and intestinal alkaline phosphatases are receptors for Aeromonas sobria hemolysin.	ALPI ALPP	3.23e-06	2	63	2	15715171
Pubmed	An ATIPical family of angiotensin II AT2 receptor-interacting proteins.	MTUS1 MTUS2	3.23e-06	2	63	2	20889352
Pubmed	Sipa1l3/SPAR3 is targeted to postsynaptic specializations and interacts with the Fezzin ProSAPiP1/Lzts3.	SIPA1L1 SIPA1L3	3.23e-06	2	63	2	26364583
Pubmed	Expression of filaggrin-2 protein in the epidermis of human skin diseases: a comparative analysis with filaggrin.	FLG FLG2	3.23e-06	2	63	2	24813994
Pubmed	HNF4 factors control chromatin accessibility and are redundantly required for maturation of the fetal intestine.	TP63 ALPI ALPP	5.38e-06	19	63	3	31345929
Pubmed	Variation in genes of the epidermal differentiation complex in German atopic dermatitis patients.	FLG HRNR FLG2	7.36e-06	21	63	3	19601998
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	KANSL1 SETD5 HIPK1 SIPA1L1 ZBTB43 SPEN ARAP2	8.99e-06	407	63	7	12693553
Pubmed	The defect seen in the phosphatidylinositol hydrolysis pathway in HIV-infected lymphocytes and lymphoblastoid cells is due to inhibition of the inositol 1,4,5-trisphosphate 1,3,4,5-tetrakisphosphate 5-phosphomonoesterase.	ALPI ALPP	9.68e-06	3	63	2	1321014
Pubmed	Two gene duplication events in the evolution of the human heat-stable alkaline phosphatases.	ALPI ALPP	9.68e-06	3	63	2	3443302
Pubmed	Dissection of a QTL hotspot on mouse distal chromosome 1 that modulates neurobehavioral phenotypes and gene expression.	FCGR2A RGS7	9.68e-06	3	63	2	19008955
Pubmed	Role of lysophosphatidylcholine in brush-border intestinal alkaline phosphatase release and restoration.	ALPI ALPP	9.68e-06	3	63	2	19407215
Pubmed	Genomic structure and comparison of mouse tissue-specific alkaline phosphatase genes.	ALPI ALPP	9.68e-06	3	63	2	2286375
Pubmed	GATA3 regulates FLG and FLG2 expression in human primary keratinocytes.	FLG FLG2	9.68e-06	3	63	2	28928464
Pubmed	Intestinal Alkaline Phosphatase Regulates Tight Junction Protein Levels.	ALPI ALPP	9.68e-06	3	63	2	27106638
Pubmed	Organic pyrophosphates as substrates for human alkaline phosphatases.	ALPI ALPP	9.68e-06	3	63	2	16742561
Pubmed	Effects of disruption of the embryonic alkaline phosphatase gene on preimplantation development of the mouse.	ALPI ALPP	9.68e-06	3	63	2	10767088
Pubmed	MUSEAP, a novel reporter gene for the study of long-term gene expression in immunocompetent mice.	ALPI ALPP	9.68e-06	3	63	2	11722850
Pubmed	Filaggrin and filaggrin 2 processing are linked together through skin aspartic acid protease activation.	FLG FLG2	9.68e-06	3	63	2	32437351
Pubmed	Analysis of the individual and aggregate genetic contributions of previously identified serine peptidase inhibitor Kazal type 5 (SPINK5), kallikrein-related peptidase 7 (KLK7), and filaggrin (FLG) polymorphisms to eczema risk.	FLG KLK7	9.68e-06	3	63	2	18774391
Pubmed	Proteolytic activation of prochemerin by kallikrein 7 breaks an ionic linkage and results in C-terminal rearrangement.	KLK7 CMKLR1	9.68e-06	3	63	2	23495698
Pubmed	A novel phosphatase upregulated in Akp3 knockout mice.	ALPI ALPP	9.68e-06	3	63	2	17901166
Pubmed	RapGAPs in brain: multipurpose players in neuronal Rap signalling.	SIPA1L1 SIPA1L3	9.68e-06	3	63	2	20576033
Pubmed	Analysis of SPINK 5, KLK 7 and FLG genotypes in a French atopic dermatitis cohort.	FLG KLK7	9.68e-06	3	63	2	17989887
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	SEC16B INTS5 KANSL1 SIPA1L1 ZNF224 RFX7 DNMBP SPEN ALPI	1.03e-05	774	63	9	15302935
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	CELSR1 INTS5 SETD5 IGHMBP2 SIPA1L1 SIPA1L3 TNRC6A DNMBP SPEN INO80D MFF FAM83B	1.35e-05	1497	63	12	31527615
Pubmed	Genetic variants associated with disordered eating.	FLG PDE8A CSMD1 FLG2	1.61e-05	83	63	4	23568457
Pubmed	Interactions between CD36 and global intestinal alkaline phosphatase in mouse small intestine and effects of high-fat diet.	ALPI ALPP	1.93e-05	4	63	2	21900644
Pubmed	Novel Role of the ALPI Gene Associated with Constipation Caused by Complement Component 3 Deficiency.	ALPI ALPP	1.93e-05	4	63	2	39273477
Pubmed	Structural evidence of functional divergence in human alkaline phosphatases.	ALPI ALPP	1.93e-05	4	63	2	12372831
Pubmed	Stage-specific expression patterns of alkaline phosphatase during development of the first arch skeleton in inbred C57BL/6 mouse embryos.	ALPI ALPP	1.93e-05	4	63	2	9061447
Pubmed	Inactivation of two mouse alkaline phosphatase genes and establishment of a model of infantile hypophosphatasia.	ALPI ALPP	1.93e-05	4	63	2	9056646
Pubmed	Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.	SIPA1L1 SIPA1L3 TNRC6A HRNR SPEN	2.15e-05	184	63	5	32908313
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	MTUS1 SIPA1L1 SIPA1L3 AKAP11 RFX7 DNMBP ARAP2 DOP1A FAM83B	2.40e-05	861	63	9	36931259
Pubmed	Central role of pyrophosphate in acellular cementum formation.	ALPI ALPP	3.22e-05	5	63	2	22675556
Pubmed	The mouse homolog of the orphan nuclear receptor tailless is expressed in the developing forebrain.	DLX1 FOXG1	3.22e-05	5	63	2	7720587
Pubmed	Two alkaline phosphatase genes are expressed during early development in the mouse embryo.	ALPI ALPP	3.22e-05	5	63	2	2133555
Pubmed	Germ cell nuclear antigen (GCNA1) expression does not require a gonadal environment or steroidogenic factor 1: examination of GCNA1 in ectopic germ cells and in Ftz-F1 null mice.	ALPI ALPP	3.22e-05	5	63	2	9291464
Pubmed	A genomic atlas of mouse hypothalamic development.	INTS5 NEXMIF SIPA1L1 DLX1 FOXG1	3.61e-05	205	63	5	20436479
Pubmed	Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.	SIPA1L1 CHD9 BSN SPEN DOP1A	3.87e-05	208	63	5	33230847
Pubmed	N6-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation.	INTS5 SETD5 HIPK1 ATG2B INO80D	4.73e-05	217	63	5	34048709
Pubmed	Expression of Cornified Envelope Proteins in Skin and Its Relationship with Atopic Dermatitis Phenotype.	FLG FLG2	4.82e-05	6	63	2	27304082
Pubmed	Sp8 is crucial for limb outgrowth and neuropore closure.	TP63 FOXG1	4.82e-05	6	63	2	14526104
Pubmed	Hydrolysis and absorption of pantothenate and its coenzymes in the rat small intestine.	ALPI ALPP	4.82e-05	6	63	2	6619987
Pubmed	Dissection of the odontoblast differentiation process in vitro by a combination of FGF1, FGF2, and TGFbeta1.	ALPI ALPP	4.82e-05	6	63	2	10878613
Pubmed	Emx1 and Emx2 functions in development of dorsal telencephalon.	DLX1 FOXG1	6.74e-05	7	63	2	9006071
Pubmed	Homeobox gene Dlx3 is regulated by p63 during ectoderm development: relevance in the pathogenesis of ectodermal dysplasias.	TP63 DLX1	6.74e-05	7	63	2	17164413
Pubmed	Replacement of Lost Lgr5-Positive Stem Cells through Plasticity of Their Enterocyte-Lineage Daughters.	ALPI ALPP	6.74e-05	7	63	2	26831517
Pubmed	Winged helix transcription factor BF-1 is essential for the development of the cerebral hemispheres.	DLX1 FOXG1	6.74e-05	7	63	2	7605629
Pubmed	Frizzled6 deficiency disrupts the differentiation process of nail development.	RPTN HRNR	6.74e-05	7	63	2	23439395
Pubmed	DYRK1A regulates the recruitment of 53BP1 to the sites of DNA damage in part through interaction with RNF169.	SIPA1L1 SIPA1L3 AKAP11 RFX7	7.32e-05	122	63	4	30773093
Pubmed	The cell proliferation antigen Ki-67 organises heterochromatin.	DNAH3 INTS5 SIPA1L1 IRAK1 DNMBP SPEN	9.97e-05	410	63	6	26949251
Pubmed	Regulation of Dlx5 and Dlx6 gene expression by p63 is involved in EEC and SHFM congenital limb defects.	TP63 DLX1	1.15e-04	9	63	2	18326838
Pubmed	microRNA-184 Induces a Commitment Switch to Epidermal Differentiation.	TP63 FLG2	1.15e-04	9	63	2	29198823
Pubmed	A Runx2/miR-3960/miR-2861 regulatory feedback loop during mouse osteoblast differentiation.	ALPI ALPP	1.15e-04	9	63	2	21324897
Pubmed	Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro.	SIPA1L1 ZBTB43 BSN	1.17e-04	52	63	3	9455477
Pubmed	Complex arrangement of genes within a 220-kb region of double-duplicated DNA on human 2q37.1.	ALPI ALPP	1.44e-04	10	63	2	11352565
Pubmed	Multimodal spatiotemporal transcriptomic resolution of embryonic palate osteogenesis.	ALPI ALPP	1.44e-04	10	63	2	37709732
Pubmed	Epiboly generates the epidermal basal monolayer and spreads the nascent mammalian skin to enclose the embryonic body.	CELSR1 TP63	1.44e-04	10	63	2	26989131
Pubmed	Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.	SEC16B PTPRN2 CSMD1 FAM83B	1.58e-04	149	63	4	25231870
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	MTUS1 SETD5 SIPA1L1 TNRC6A IRAK1 CHD9 CSMD1 INO80D ARAP2	1.74e-04	1116	63	9	31753913
Pubmed	IFN-λ derived from nonsusceptible enterocytes acts on tuft cells to limit persistent norovirus.	ALPI ALPP	1.76e-04	11	63	2	37703370
Pubmed	A dual role for planar cell polarity genes in ciliated cells.	CELSR1 FOXG1	1.76e-04	11	63	2	25024228
Pubmed	A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity.	KLK7 HRNR FLG2	1.98e-04	62	63	3	26644517
Pubmed	A YY1-dependent increase in aerobic metabolism is indispensable for intestinal organogenesis.	ALPI ALPP	2.11e-04	12	63	2	27802136
Pubmed	TNAP limits TGF-β-dependent cardiac and skeletal muscle fibrosis by inactivating the SMAD2/3 transcription factors.	ALPI ALPP	2.11e-04	12	63	2	31289197
Pubmed	Patterning of the dorsal telencephalon and cerebral cortex by a roof plate-Lhx2 pathway.	DLX1 FOXG1	2.11e-04	12	63	2	11719201
Pubmed	LncRNA SAMD12-AS1 promotes cell proliferation and inhibits apoptosis by interacting with NPM1.	FLG HRNR	2.11e-04	12	63	2	31406141
Pubmed	The Rb/E2F pathway modulates neurogenesis through direct regulation of the Dlx1/Dlx2 bigene cluster.	DLX1 FOXG1	2.49e-04	13	63	2	22699903
Pubmed	Establishment of smooth muscle and cartilage juxtaposition in the developing mouse upper airways.	TP63 FOXG1	2.49e-04	13	63	2	24218621
Pubmed	Dbx1-expressing cells are necessary for the survival of the mammalian anterior neural and craniofacial structures.	DLX1 FOXG1	2.49e-04	13	63	2	21552538
Pubmed	General transcription factor TAF4 antagonizes epigenetic silencing by Polycomb to maintain intestine stem cell functions.	ALPI ALPP	2.90e-04	14	63	2	36639541
Pubmed	Defects in Stratum Corneum Desquamation Are the Predominant Effect of Impaired ABCA12 Function in a Novel Mouse Model of Harlequin Ichthyosis.	KLK7 RPTN	2.90e-04	14	63	2	27551807
Pubmed	PRDM14 directly interacts with heat shock proteins HSP90α and glucose-regulated protein 78.	FLG HRNR	2.90e-04	14	63	2	29178343
Pubmed	C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.	PDE8A ATG2B AKAP11 MFF FAM83B LRP8	3.04e-04	504	63	6	34432599
Pubmed	Expression of the winged helix genes fkh-4 and fkh-5 defines domains in the central nervous system.	IGHMBP2 DLX1	3.81e-04	16	63	2	8861101
Pubmed	TRIM30 modulates Interleukin-22-regulated papillary thyroid Cancer cell migration and invasion by targeting Sox17 for K48-linked Polyubiquitination.	HRNR FLG2	3.81e-04	16	63	2	31823782
Pubmed	Tracing the origin of adult intestinal stem cells.	ALPI ALPP	3.81e-04	16	63	2	31092921
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	INTS5 MTUS1 TNRC6A AKAP11 BSN DNMBP	3.93e-04	529	63	6	14621295
Pubmed	MOF-mediated histone H4 Lysine 16 acetylation governs mitochondrial and ciliary functions by controlling gene promoters.	KANSL1 TP63	4.32e-04	17	63	2	37479688
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	HIPK1 SIPA1L1 SIPA1L3 ZBTB43 CHD9 ZNF224 USP9Y MTUS2 WAC	4.90e-04	1285	63	9	35914814
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	TNRC6A HRNR FLG2 SPEN MFF ARAP2 FAM83B	5.05e-04	777	63	7	35844135
Pubmed	Multiple roles for HOXA3 in regulating thymus and parathyroid differentiation and morphogenesis in mouse.	TP63 FOXG1	5.41e-04	19	63	2	25249461
Pubmed	Dnmt1 is essential to maintain progenitors in the perinatal intestinal epithelium.	ALPI ALPP	6.01e-04	20	63	2	26023099
Pubmed	Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters.	ZNF224 ZNF112	6.01e-04	20	63	2	12743021
Pubmed	Zinc-finger genes Fez and Fez-like function in the establishment of diencephalon subdivisions.	DLX1 FOXG1	6.01e-04	20	63	2	16971467
Pubmed	Distinct regulatory cascades govern extraocular and pharyngeal arch muscle progenitor cell fates.	ALPI ALPP	6.01e-04	20	63	2	19531352
Pubmed	TRIM25 and DEAD-Box RNA Helicase DDX3X Cooperate to Regulate RIG-I-Mediated Antiviral Immunity.	FLG HRNR FLG2	6.14e-04	91	63	3	34445801
Pubmed	The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis.	SIPA1L1 SIPA1L3 TNRC6A BSN	6.70e-04	218	63	4	33378226
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	HIPK1 TNRC6A BSN DNMBP SPEN FAM83B	6.84e-04	588	63	6	38580884
Pubmed	Functional roles of Lgr4 and Lgr5 in embryonic gut, kidney and skin development in mice.	ALPI ALPP	7.97e-04	23	63	2	24680895
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	CELSR1 INTS5 KANSL1 SETD5 SIPA1L3 IRAK1 DNMBP SPEN	8.34e-04	1105	63	8	35748872
Pubmed	Emx2 directs the development of diencephalon in cooperation with Otx2.	DLX1 FOXG1	8.69e-04	24	63	2	11493561
Pubmed	A conserved Pbx-Wnt-p63-Irf6 regulatory module controls face morphogenesis by promoting epithelial apoptosis.	TP63 FOXG1	8.69e-04	24	63	2	21982646
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	MTUS1 SIPA1L1 SIPA1L3 TNRC6A IRAK1 DNMBP FAM83B	8.74e-04	853	63	7	28718761
Pubmed	Pax6 limits the competence of developing cerebral cortical cells to respond to inductive intercellular signals.	DLX1 FOXG1	9.43e-04	25	63	2	36067211
Pubmed	Human Immunodeficiency Virus Type 1 Vpr Mediates Degradation of APC1, a Scaffolding Component of the Anaphase-Promoting Complex/Cyclosome.	ATG2B TNRC6A IRAK1 AKAP11	9.87e-04	242	63	4	34011540
Cytoband	1q21.3	FLG RPTN HRNR FLG2	2.12e-05	117	63	4	1q21.3
Cytoband	Ensembl 112 genes in cytogenetic band chr16p12	DNAH3 C16orf82 TNRC6A TMC5	9.54e-05	172	63	4	chr16p12
Cytoband	Ensembl 112 genes in cytogenetic band chr1q21	FLG RPTN NBPF10 HRNR FLG2	2.38e-04	404	63	5	chr1q21
Cytoband	16p12.3	DNAH3 TMC5	1.01e-03	34	63	2	16p12.3
GeneFamily	EF-hand domain containing\|S100 fused type protein family	FLG RPTN HRNR FLG2	8.76e-10	7	42	4	1350
GeneFamily	Alkaline phosphatases	ALPI ALPP	3.15e-05	4	42	2	1072
GeneFamily	EF-hand domain containing	FLG RPTN HRNR FLG2	1.63e-03	219	42	4	863
ToppCell	COVID-19-kidney-Technical/muscle_(Mes)\|kidney / Disease (COVID-19 only), tissue and cell type	DNAH3 PTPRN2 CSMD1 RGS7 MTUS2	3.08e-06	159	63	5	5335cbcdeaf2bbd0268bbfe0e45c8c0d288e640d
ToppCell	TCGA-Skin-Primary_Tumor-Melanoma-Skin_Cutaneous_Melanoma-6\|TCGA-Skin / Sample_Type by Project: Shred V9	KLK7 RPTN TP63 FLG2 FAM83B	6.80e-06	187	63	5	2ca7928baf0c5e61f7294ed05e6e6f0e0adf9d3f
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8\|GI_small-bowel / Manually curated celltypes from each tissue	KANSL1 HIPK1 SPEN INO80D ARAP2	6.97e-06	188	63	5	ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCell	COVID-19-lung-Secretory\|lung / Disease (COVID-19 only), tissue and cell type	CELSR1 MTUS1 TP63 TMC5 FAM83B	7.16e-06	189	63	5	84d48e3ed25bebb8bb8074b3a2c5e2e88cff7f25
ToppCell	Tracheal-NucSeq\|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations	KANSL1 SIPA1L3 TNRC6A RFX7 INO80D	9.19e-06	199	63	5	94b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW13-Mesenchymal-Mesoderm\|GW13 / Sample Type, Dataset, Time_group, and Cell type.	LRRC37A2 IRAK1 RFX7 MAP10 DNMBP	9.41e-06	200	63	5	0f4b8b0868bda406fe6bf01d1b722510fdfd0168
ToppCell	Control-Epithelial_airway\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DNAH3 CELSR1 TMC5 FAM83B	7.42e-05	158	63	4	35aee1c3b92169e73569331022833cb44ab7e7e8
ToppCell	Children_(3_yrs)-Epithelial-basal_cell-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CELSR1 ATOH8 TP63 FAM83B	7.42e-05	158	63	4	d78e7e52657dc094430291fec07e9c298be9e584
ToppCell	TCGA-Stomach-Primary_Tumor-Stomach_Adenocarcinoma-Stomach_Adenocarcinoma_-_Tubular-6\|TCGA-Stomach / Sample_Type by Project: Shred V9	INTS5 SIPA1L3 DNMBP LRP8	7.61e-05	159	63	4	655c0749c238bd68cb797adb83e25a23b8a3cc9d
ToppCell	Children_(3_yrs)-Epithelial-lung_neuroendocrine_cell_(PNEC)-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	PTPRN2 RGS7 MTUS2 FAM83B	9.20e-05	167	63	4	c87ebfa8c3284ad33579190e148c95bcaf670d17
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Degenerative_Proximal_Tubule_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DNAH3 CSMD1 TMC5 MTUS2	9.20e-05	167	63	4	3edb0570e583bb527165bcd8a4c25a042054043b
ToppCell	3'_v3-GI_small-bowel-Lymphocytic_B\|GI_small-bowel / Manually curated celltypes from each tissue	CELSR1 NEXMIF TP63 RGS7	9.41e-05	168	63	4	5535c1b8b7fde7b59a1bc0580cebdfa963aa1c39
ToppCell	3'_v3-GI_small-bowel-Lymphocytic_B-Memory_B_cells\|GI_small-bowel / Manually curated celltypes from each tissue	CELSR1 NEXMIF TP63 RGS7	9.41e-05	168	63	4	8e025bb0541746e232b77ac0e31412ae71420c47
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Hematologic-coronary_vascular_endothelial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KLK7 KANSL1 HIPK1 SPEN	9.63e-05	169	63	4	4e1322cc5e1733e9fb19e08f739a30206f43cea8
ToppCell	5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TP63 CSMD1 FLG2 FAM83B	9.85e-05	170	63	4	2d880223d01bde4bf777bd6f50b7d2768489075f
ToppCell	5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting-Basal_resting_L.0.0.0.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TP63 CSMD1 FLG2 FAM83B	9.85e-05	170	63	4	0cc20322cb3e3e7bbd4daad8785c99f80e355c16
ToppCell	3'-GW_trimst-2-SmallIntestine-Neuronal-Glial_immature-ENCC/glia_Progenitor\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DLX1 RFX7 DOP1A LRP8	1.01e-04	171	63	4	b51bbeacb172e8b5de519ada85543d7ae9914b3c
ToppCell	droplet-Fat-Bat-18m-Mesenchymal-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEC16B MTUS1 CSMD1 BBS12	1.10e-04	175	63	4	b4f01e7782cdd107d0817ef601891fd3a382bc35
ToppCell	droplet-Fat-Bat-18m-Mesenchymal-mesenchymal_stem_cell_of_adipose\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEC16B MTUS1 CSMD1 BBS12	1.10e-04	175	63	4	ef6f811d8e1839f405c3b41090ddf79be57a099f
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW10-Neuronal-GABAergic_neurons\|GW10 / Sample Type, Dataset, Time_group, and Cell type.	CBLL2 RPTN TP63 DLX1	1.10e-04	175	63	4	d4ff1f197ad4086286e86817cbff24fa718293fc
ToppCell	droplet-Fat-Bat-18m-Mesenchymal\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEC16B MTUS1 CSMD1 BBS12	1.10e-04	175	63	4	7f7598d46d10bff1cbea42f950bdde1aaa16e9a4
ToppCell	LPS-IL1RA+antiTNF\|World / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	IGSF10 MTUS1 ATOH8 USP9Y	1.15e-04	177	63	4	b7fee75de7e96924af488a5baa2334711889ae7c
ToppCell	356C-Lymphocytic-CD4_T-cell-Treg_cell_1\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	MTUS1 LRRC37A2 ZNF224 TMC5	1.15e-04	177	63	4	36b5d29caa9cffbc0284f771a4db71aa72171a89
ToppCell	COVID-19-Epithelial_cells-Airway_club\|COVID-19 / group, cell type (main and fine annotations)	CELSR1 MTUS1 NEXMIF TMC5	1.36e-04	185	63	4	cfe6fd73d817e173fe803bc1683c291d9bcb8608
ToppCell	343B-Lymphocytic-CD4_T-cell-Treg_cell_1\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	MTUS1 PTPRN2 SIPA1L1 ZNF224	1.39e-04	186	63	4	76cbc3610aedf8c19c17ad5faf6ef5e8980b6af5
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CELSR1 MTUS1 ATOH8 SIPA1L3	1.42e-04	187	63	4	58d48128547ee3513d0bf7f78e61b76b1c472ca9
ToppCell	367C-Epithelial_cells-Epithelial-H_(AT1)-\|367C / Donor, Lineage, Cell class and subclass (all cells)	CELSR1 TP63 TMC5 FAM83B	1.45e-04	188	63	4	61422c7919ca0ea02d6be4302f11b169a3ce35e5
ToppCell	10x5'-GI_large-bowel-Myeloid_Monocytic\|GI_large-bowel / Manually curated celltypes from each tissue	FCGR2A ATOH8 CMKLR1 ZNF112	1.45e-04	188	63	4	d0045fdda757d191dabc7853f6a6e99c0e97d93d
ToppCell	367C-Epithelial_cells-Epithelial-H_(AT1)\|367C / Donor, Lineage, Cell class and subclass (all cells)	CELSR1 TP63 TMC5 FAM83B	1.45e-04	188	63	4	18698f0b22ccbc2b93759acc1c8dbdb30a6b5a16
ToppCell	10x5'-GI_large-bowel-Myeloid_Monocytic-Classical_monocytes\|GI_large-bowel / Manually curated celltypes from each tissue	FCGR2A ATOH8 CMKLR1 ZNF112	1.45e-04	188	63	4	0bcf04aa47738f43c1a87dae5dc487738ee86f8c
ToppCell	TCGA-Skin-Primary_Tumor\|TCGA-Skin / Sample_Type by Project: Shred V9	KLK7 RPTN TP63 FLG2	1.51e-04	190	63	4	e2b26a03c6ab24d9b0f4150c47597be37767d86e
ToppCell	TCGA-Skin-Primary_Tumor-Melanoma\|TCGA-Skin / Sample_Type by Project: Shred V9	KLK7 RPTN TP63 FLG2	1.51e-04	190	63	4	01fb45add4661bc86cd0a34fac35177907152dbb
ToppCell	COVID-19-Epithelial_cells-Airway_goblet\|COVID-19 / group, cell type (main and fine annotations)	CELSR1 MTUS1 NEXMIF TMC5	1.51e-04	190	63	4	51ca9ef4df3220487152fcf684147730637c7cc1
ToppCell	TCGA-Skin-Primary_Tumor-Melanoma-Skin_Cutaneous_Melanoma\|TCGA-Skin / Sample_Type by Project: Shred V9	KLK7 RPTN TP63 FLG2	1.51e-04	190	63	4	3188c7bd225cbcf46a21e2fb784336cdd9665995
ToppCell	COPD-Myeloid-cDC2\|World / Disease state, Lineage and Cell class	SIPA1L1 SIPA1L3 CSMD1 DNMBP	1.54e-04	191	63	4	4e4887175200a57e1b041f2f131e3df774df3509
ToppCell	COPD-Myeloid-cDC2\|COPD / Disease state, Lineage and Cell class	SIPA1L1 SIPA1L3 CSMD1 DNMBP	1.54e-04	191	63	4	2af6e4a6bd1f2193ece2131c3b7d976dd23a6966
ToppCell	COPD-Myeloid-cDC2\|Myeloid / Disease state, Lineage and Cell class	SIPA1L1 SIPA1L3 CSMD1 DNMBP	1.57e-04	192	63	4	984cdc2f1d93e164bc946d63f58dacb629f82eb7
ToppCell	LV-08._Macrophage\|LV / Chamber and Cluster_Paper	FCGR2A SIPA1L1 CMKLR1 ARAP2	1.57e-04	192	63	4	7be12d580aaf2f2f1562203fcad3a44639b8c5a6
ToppCell	Epithelial-club_cell\|World / Lineage, Cell type, age group and donor	CELSR1 MTUS1 NEXMIF TMC5	1.60e-04	193	63	4	2bdd09004fa433550958ec42ba4b06271a4aaf7c
ToppCell	COPD-Myeloid-Macrophage\|World / Disease state, Lineage and Cell class	FCGR2A SIPA1L1 CSMD1 DNMBP	1.64e-04	194	63	4	7d682408e9a6239a4e47befc9376e760cc3d133a
ToppCell	severe-B_cell\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	CELSR1 TP63 RGS7 DOP1A	1.67e-04	195	63	4	0fc3c605609c9e6bdea15d73c45def2188ae5fb1
ToppCell	Bronchial-NucSeq\|Bronchial / Cell types per location group and 10X technology with lineage, and cell group designations	KANSL1 SIPA1L1 SIPA1L3 RFX7	1.70e-04	196	63	4	ab53c742866945545a92e2e61850d63c80d9a2a6
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PTPRN2 CSMD1 RGS7 MTUS2	1.70e-04	196	63	4	676c56b44ac29f7baecb62f49bb8597cc74c0a88
ToppCell	NS-critical-LOC-Epithelial-Squamous\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	FLG KLK7 MTUS1 RPTN	1.70e-04	196	63	4	453c809494ceffa2a28af283c4b5a4924fcf160f
ToppCell	LPS_IL1RA_TNF\|World / Treatment groups by lineage, cell group, cell type	IGSF10 MTUS1 ATOH8 CHD9	1.74e-04	197	63	4	0a6550dce156fc81f15b1e7830d331ca50d87d06
ToppCell	Somatosensory_Cortex_(S1)-Neuronal\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PTPRN2 CSMD1 RGS7 MTUS2	1.77e-04	198	63	4	c01091ef18e096d792ea2a7a715764a5b215355f
ToppCell	primary_auditory_cortex_(A1C)-Neuronal\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PTPRN2 CSMD1 RGS7 MTUS2	1.77e-04	198	63	4	6d18b45eda4014759e6dd282d78ffd28df8a6044
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PTPRN2 CSMD1 RGS7 MTUS2	1.77e-04	198	63	4	8ab40fae14fe02e39bc8c8da187a5cd60c787643
ToppCell	Fetal_29-31_weeks-Epithelial-club_cell-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CELSR1 MTUS1 NEXMIF TMC5	1.77e-04	198	63	4	6ba5e5970109a04ed968bac7ff099ae250c579dc
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PTPRN2 CSMD1 RGS7 MTUS2	1.77e-04	198	63	4	0ff30edfd3c133a42e8cb96e1631a1143215f808
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-Newborn-35\|World / Primary Cells by Cluster	CHD9 DLX1 FOXG1 LRP8	1.77e-04	198	63	4	de5214a85fe017eb23d4aa8af624464f062ec57e
ToppCell	Fetal_29-31_weeks-Epithelial-club_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CELSR1 MTUS1 NEXMIF TMC5	1.77e-04	198	63	4	5fc25b008a4d8d6bec83923a16f64dd9e1ff1f2d
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PTPRN2 CSMD1 RGS7 MTUS2	1.77e-04	198	63	4	4ca5ff320905ab4ff60ed90a5522227c782142a6
ToppCell	Parenchymal-NucSeq-Epithelial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CELSR1 MTUS1 SIPA1L3 TMC5	1.80e-04	199	63	4	5cea0d9e261903e0eaad60c28a07dff72ce65027
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-4M\|organoid_Kanton_Nature / Sample Type, Dataset, Time_group, and Cell type.	AKAP11 DLX1 BSN FOXG1	1.80e-04	199	63	4	b2d7dea11207cca63d688f8051143850b29dbdf0
ToppCell	Transverse-Macrophage-LYVE1_Macrophage\|Transverse / Region, Cell class and subclass	FCGR2A CMKLR1 FLG2 ZNF491	1.80e-04	199	63	4	facf79c256db5ae57bdb613e86ec90616a6f67ca
ToppCell	Transverse-(6)_Macrophage-(61)_LYVE1_Macrophage\|Transverse / shred on region, Cell_type, and subtype	FCGR2A CMKLR1 FLG2 ZNF491	1.80e-04	199	63	4	dcc2a7f4d1fa30aaaad655dd59c5a2b039d264bf
ToppCell	COVID-19-COVID-19_Mild-Lymphocyte-T/NK-NK_activated\|COVID-19_Mild / Disease, condition lineage and cell class	NBPF10 CMKLR1 USP9Y ARAP2	1.84e-04	200	63	4	2281debd86e5d92e8fe0397aec9ef670800f7471
ToppCell	Neuronal\|World / cells hierarchy compared to all cells using T-Statistic	PTPRN2 CSMD1 RGS7 MTUS2	1.84e-04	200	63	4	48d801219bc771d6c7e151dc88ca4c179988de85
ToppCell	lung-Type_I_Pneumocytes\|lung / shred on tissue and cell subclass	KLK7 KANSL1 FCGR2A	2.14e-04	82	63	3	6023212a51f8b3e05e6c3dcf4e8fbf53ba696fb2
Drug	dioxetane	TP63 PISD ALPI ALPP	1.12e-06	29	62	4	CID000122029
Drug	photobiotin	FCGR2A ALPI ALPP	2.28e-06	10	62	3	CID003035428
Drug	4-aminophenyl phosphate	ALPI ALPP	7.30e-06	2	62	2	CID000122270
Drug	3-(hydroxymethyl)phenytoin	ALPI ALPP	7.30e-06	2	62	2	ctd:C043104
Drug	5-bromo-4-chloroindoxyl	ALPI ALPP	7.30e-06	2	62	2	CID009964843
Drug	fast red violet LB salt	ALPI ALPP	7.30e-06	2	62	2	CID006370075
Drug	5-hydroxycytidine	ALPI ALPP	2.18e-05	3	62	2	CID000198207
Drug	Alphostatin	ALPI ALPP	2.18e-05	3	62	2	CID000174788
Drug	3-indoxyl phosphate	ALPI ALPP	4.36e-05	4	62	2	CID000026292
Drug	p-bromotetramisole	ALPI ALPP	4.36e-05	4	62	2	CID000005121
Drug	ammediol	ALPI ALPP	4.36e-05	4	62	2	CID000001531
Drug	Fast Blue RR Base	ALPI ALPP	4.36e-05	4	62	2	CID000080442
Drug	Sb15	ALPI ALPP	4.36e-05	4	62	2	CID000044950
Drug	naphthol AS phosphate	ALPI ALPP	4.36e-05	4	62	2	CID000084137
Drug	ethylethanolamine	ALPI ALPP	4.36e-05	4	62	2	CID000008072
Drug	Fast Blue RR	ALPI ALPP	7.26e-05	5	62	2	CID000093116
Drug	SMR 6	ALPI ALPP	7.26e-05	5	62	2	CID006439864
Drug	dendrodoine	ALPI ALPP	7.26e-05	5	62	2	CID000126514
Drug	ranelic acid	ALPI ALPP	7.26e-05	5	62	2	CID003052774
Drug	mitomycin phosphate	ALPI ALPP	7.26e-05	5	62	2	CID000130219
Drug	6-thioxanthosine	ALPI ALPP	7.26e-05	5	62	2	CID004023632
Drug	naphthol AS-TR phosphate	ALPI ALPP	1.09e-04	6	62	2	CID000075794
Drug	O,O,S-trimethylphosphorodithioate	ALPI ALPP	1.09e-04	6	62	2	CID000018065
Drug	5-fluorosalicylic acid	ALPI ALPP	1.09e-04	6	62	2	CID000067658
Drug	FADP	ALPI ALPP	1.09e-04	6	62	2	CID003081481
Drug	lead;sulfide	ALPI ALPP	1.09e-04	6	62	2	CID009794739
Drug	DSCG	PTPRN2 ALPI ALPP	1.29e-04	36	62	3	CID003011861
Drug	Laurdan	FCGR2A TP63 FOXG1	1.52e-04	38	62	3	CID000104983
Drug	nitrophenylphosphate	ALPI ALPP	1.52e-04	7	62	2	ctd:C008644
Drug	p-aminodiphenylamine	ALPI ALPP	1.52e-04	7	62	2	CID000007564
Drug	Flutamide [13311-84-7]; Down 200; 14.4uM; MCF7; HT_HG-U133A	MTUS1 HIPK1 SIPA1L3 ZBTB43 INO80D	1.86e-04	194	62	5	4361_DN
Drug	Mefexamide hydrochloride [3413-64-7]; Up 200; 12.6uM; PC3; HT_HG-U133A	INTS5 MTUS1 ZBTB43 ZNF224 INO80D	1.91e-04	195	62	5	2121_UP
Drug	Isoconazole [27523-40-6]; Down 200; 9.6uM; PC3; HT_HG-U133A	CELSR1 INTS5 ZBTB43 TMC5 DNMBP	1.95e-04	196	62	5	2056_DN
Drug	Fluorocurarine chloride [22273-09-2]; Down 200; 11.6uM; HL60; HT_HG-U133A	INTS5 IGHMBP2 SIPA1L1 INO80D ARAP2	1.95e-04	196	62	5	2521_DN
Drug	Ticarcillin sodium [4697-14-7]; Down 200; 9.4uM; MCF7; HT_HG-U133A	IGHMBP2 KREMEN2 PISD TMC5 DNMBP	2.00e-04	197	62	5	7185_DN
Drug	fosfosal	ALPI ALPP	2.02e-04	8	62	2	CID000003418
Drug	iopentol	ALPI ALPP	2.02e-04	8	62	2	CID000056016
Drug	sodium monofluorophosphate	SPEN ALPI	2.02e-04	8	62	2	CID000024266
Drug	(1S,2E,3S)-2-[(2E)-2-[(7aR)-7a-methyl-1-[(E,1R,4R)-1,4,5-trimethylhex-2-enyl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-3-methyl-cyclohexanol	ALPI ALPP	2.02e-04	8	62	2	CID011953890
Drug	orellanine	ALPI ALPP	2.02e-04	8	62	2	CID000089579
Drug	Hydroflumethiazide [135-09-1]; Up 200; 12uM; HL60; HT_HG-U133A	PTPRN2 SIPA1L3 DNMBP INO80D DOP1A	2.05e-04	198	62	5	1851_UP
Drug	Chlorprothixene hydrochloride [6469-93-8]; Up 200; 11.4uM; HL60; HT_HG-U133A	DNAH3 MTUS1 SIPA1L1 DNMBP INO80D	2.05e-04	198	62	5	1272_UP
Drug	CP-320650-01 [172079-28-6]; Up 200; 10uM; PC3; HT_HG-U133A	CT62 PTPRN2 TP63 ZBTB43 USP9Y	2.10e-04	199	62	5	3822_UP
Drug	N6,2-O-dibutyryladenosine 3,5-cyclic monophosphate sodium salt; Down 200; 2uM; MCF7; HT_HG-U133A_EA	MTUS1 IGHMBP2 SIPA1L3 RFX7 DOP1A	2.10e-04	199	62	5	959_DN
Drug	lissamine	MFF ALPI ALPP	2.35e-04	44	62	3	CID005359521
Drug	aminohexane	ALPI ALPP	2.59e-04	9	62	2	CID000201427
Drug	phenolphthalein monophosphate	ALPI ALPP	2.59e-04	9	62	2	CID000128862
Drug	R 8231	ALPI ALPP	2.59e-04	9	62	2	CID003084926
Drug	Ponceau S solution	ALPI ALPP	2.59e-04	9	62	2	CID005473620
Drug	Aphos	ALPI ALPP	2.59e-04	9	62	2	CID000053051
Drug	pingyangmycin	TP63 FOXG1	2.59e-04	9	62	2	CID000084046
Drug	fosfluconazole	ALPI ALPP	2.59e-04	9	62	2	CID000214356
Drug	naphthol AS-TR	ALPI ALPP	2.59e-04	9	62	2	CID000066718
Drug	thymol	SPEN ALPI ALPP	2.69e-04	46	62	3	CID000006989
Disease	Neurodevelopmental Disorders	SETD5 NEXMIF FOXG1 WAC	3.94e-05	93	60	4	C1535926
Disease	heart rate	CELSR1 TP63 SIPA1L1 TNRC6A CSMD1	9.57e-05	225	60	5	EFO_0004326
Disease	postburn hypertrophic scarring severity measurement	CSMD1 ARAP2	1.81e-04	10	60	2	EFO_0007747
Disease	diffuse scleroderma (is_implicated_in)	FCGR2A IRAK1	2.21e-04	11	60	2	DOID:1580 (is_implicated_in)
Disease	triacylglycerol 44:1 measurement	C16orf82 CSMD1	2.65e-04	12	60	2	EFO_0010399
Disease	triacylglycerol 46:2 measurement	C16orf82 CSMD1	3.64e-04	14	60	2	EFO_0010402
Disease	Congenital total cataract	SIPA1L3 DNMBP	4.79e-04	16	60	2	C0266539
Disease	response to triptolide, cytotoxicity measurement	CSMD1 MTUS2	4.79e-04	16	60	2	EFO_0006952, EFO_0007662
Disease	phosphatidylcholine 40:6 measurement	CSMD1 TMC5	5.42e-04	17	60	2	EFO_0010389
Disease	triacylglycerol 48:1 measurement	C16orf82 CSMD1	5.42e-04	17	60	2	EFO_0010404
Disease	response to methotrexate, juvenile idiopathic arthritis	CMKLR1 CSMD1	6.80e-04	19	60	2	EFO_0002609, GO_0031427
Disease	triacylglycerol 46:1 measurement	C16orf82 CSMD1	7.55e-04	20	60	2	EFO_0010401
Disease	nighttime rest measurement	SEC16B CSMD1	1.09e-03	24	60	2	EFO_0007827
Disease	triacylglycerol 48:0 measurement	C16orf82 CSMD1	1.28e-03	26	60	2	EFO_0010403
Disease	age at menarche	SEC16B PTPRN2 TNRC6A CSMD1 BSN FAM83B	1.29e-03	594	60	6	EFO_0004703
Disease	cholesteryl ester 14:0 measurement	PTPRN2 RGS7	1.38e-03	27	60	2	EFO_0010340
Disease	neuroimaging measurement	CELSR1 KANSL1 PDE8A TP63 TNRC6A TMC5 FOXG1 LRP8	1.39e-03	1069	60	8	EFO_0004346

Protein segments in the cluster

Peptide	Gene	Start	Entry
NPDQDSSSHYHGTSS	CSMD1	3471	Q96PZ7
TFSIPQANHSHSGDY	FCGR2A	171	P12318
LQPSSQNHRFYHSTG	AKAP11	1511	Q9UKA4
YSHIPVDSNHNFRSS	DOP1A	1436	Q5JWR5
YNPRRSHSDASVGSH	DNMBP	1346	Q6XZF7
VNRHSYPLSSTSGNA	ARAP2	446	Q8WZ64
HSAGHSQPDGAYSSA	DLX1	46	P56177
DANTHRPVFQSSHYT	CELSR1	781	Q9NYQ6
GYHHSHTTPQGRSDA	FLG	1516	P20930
FRHSQHGSVSYNSNP	FLG	3991	P20930
HHLQNATDSGSPSSY	BBS12	621	Q6ZW61
QNGNPSASEFASHHY	CBLL2	346	Q8N7E2
VSQESGPTYASFSHH	ATG2B	1461	Q96BY7
GNTNSSEPENRTHFH	MTUS2	61	Q5JR59
AENSHSHSDYINASP	PTPRN2	791	Q92932
SHVIYNNHQDSSASP	ATOH8	196	Q96SQ7
HESTSSQSLGYDQHG	FLG2	456	Q5D862
HESRSGQSSYGQHSS	FLG2	761	Q5D862
SGFGQHESRSHQSSY	FLG2	831	Q5D862
TRHSYSGHEQTTQTG	FLG2	1551	Q5D862
YSDSEGHSGFSQRPH	FLG2	1806	Q5D862
HDSSSRTENPKHSQY	MAP10	726	Q9P2G4
NTNYNHPHEADSAGT	LRRC37A2	1416	A6NM11
ATSNPHHDNVRYGIS	MFF	261	Q9GZY8
DESNSEPHSQSSYRH	MTUS1	316	Q9ULD2
QGSSRHAAAYTTHPS	HIPK1	1136	Q86Z02
SQPSRASSAYHHASD	BSN	3706	Q9UPA5
ASSSREGYVSHHNTP	FAM83B	426	Q5T0W9
EGYVSHHNTPAQSFA	FAM83B	431	Q5T0W9
LHHPRASSTLSYNGT	FOXG1	316	P55316
SSNPYHNSTHSADVL	PDE8A	551	O60658
QSSSYGQHESASRHS	HRNR	396	Q86YZ3
QHDSSSGQSSSYGQH	HRNR	856	Q86YZ3
SGQSSSYGQHESASH	HRNR	861	Q86YZ3
SKSFRHPGYSTQTHV	KLK7	96	P49862
SSHSLSEYSHGQSPR	KANSL1	976	Q7Z3B3
TQQHSYSSASDPHGR	KREMEN2	66	Q8NCW0
SHDSGNFQHRISSSP	OVOS2	481	Q6IE36
SPQENSYVSSTGRAH	IRAK1	541	P51617
QHASPAGTYAHTVNR	ALPI	171	P09923
TRVQHASPAGTYAHT	ALPP	171	P05187
NGSSSTSPYNTDHAQ	TP63	126	Q9H3D4
HSSHPQGNYSNSKLS	CHD9	341	Q3L8U1
VSEPRHNHFYSHTTQ	IGSF10	961	Q6WRI0
HHHRGPSDSIANNYS	DNAH3	101	Q8TD57
TSRQQYSSDHSHSSP	INO80D	811	Q53TQ3
SSPEEVFHSGHSRNS	FAM102A	216	Q5T9C2
VFHSGHSRNSSYASQ	FAM102A	221	Q5T9C2
TDQPSAYSHTHRTFS	CT62	16	P0C5K7
PGTTVHRSTYQNHST	LRP8	761	Q14114
HRSTYQNHSTETPSL	LRP8	766	Q14114
YGLQNDIRSHSPTHT	RGS7	231	P49802
TYSNSHGSYDSNQPH	NBPF10	481	Q6P3W6
NNTSISYFSHHSPEQ	NEXMIF	826	Q5QGS0
SYFSHHSPEQNEGSL	NEXMIF	831	Q5QGS0
PNKQGHSDSHYSSHS	SIPA1L1	1271	O43166
NRHSKGEPQYSSHSS	SIPA1L3	1256	O60292
SAVSNSQHYPHRGSG	SETD5	1406	Q9C0A6
GGTSYSPQENSHNHS	WAC	91	Q9BTA9
SSTYSGQHQRVPHAT	INTS5	156	Q6P9B9
NALSEDTGHSSYPSH	CMKLR1	336	Q99788
HGSDHQSPSSSSYNG	ZBTB43	136	O43298
NYQHSRSRSPHSSQS	SPEN	236	Q96T58
YSHENSQGSSHAATK	IGHMBP2	651	P38935
DLHTNSPRHSKGSYN	PISD	336	Q9UG56
PGQSYQSQSRHHDTH	RFX7	1006	Q2KHR2
SDSSTASPGNHRNHY	USP9Y	981	O00507
HYENQHSPFGTNSET	SEC16B	161	Q96JE7
SYLQSHQSVHSGERP	ZNF112	706	Q9UJU3
YSPSSFQRHERSHTG	ZNF491	281	Q8N8L2
SSSGNYAGSRTHPDH	TMC5	141	Q6UXY8
TNSQCYSHQRSHSGE	ZNF224	411	Q9NZL3
SSHYSQTDRQGQSSH	RPTN	316	Q6XPR3
SSHYGQPDTQDQSSH	RPTN	376	Q6XPR3
SSHYGQPDRQGQNSH	RPTN	436	Q6XPR3
IYGVTSPQRGHSQHS	C16orf82	41	Q7Z2V1
SDINHSTSGSHYENS	TNRC6A	196	Q8NDV7
HYENSQRGPVSSTSD	TNRC6A	206	Q8NDV7