Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	SPAR_C	SIPA1L2 SIPA1L1	1.48e-05	3	42	2	PF11881
Domain	SIPA1L_C	SIPA1L2 SIPA1L1	1.48e-05	3	42	2	IPR021818
Domain	Rap_GAP	SIPA1L2 SIPA1L1	2.20e-04	10	42	2	PF02145
Domain	Rap_GAP_dom	SIPA1L2 SIPA1L1	2.68e-04	11	42	2	IPR000331
Domain	RAPGAP	SIPA1L2 SIPA1L1	2.68e-04	11	42	2	PS50085
Domain	FN3_dom	MYOM2 F3 ITGB4 SPEG	1.22e-03	209	42	4	IPR003961
Domain	fn3	MYOM2 ITGB4 SPEG	5.74e-03	162	42	3	PF00041
Domain	FN3	MYOM2 ITGB4 SPEG	8.27e-03	185	42	3	SM00060
Domain	Ig_I-set	MYOM2 FGFR1 SPEG	8.89e-03	190	42	3	IPR013098
Domain	I-set	MYOM2 FGFR1 SPEG	8.89e-03	190	42	3	PF07679
Pubmed	DYRK1A regulates the recruitment of 53BP1 to the sites of DNA damage in part through interaction with RNF169.	USP7 JCAD ICE1 SIPA1L2 SIPA1L1	5.34e-07	122	45	5	30773093
Pubmed	LKB1-regulated adaptive mechanisms are essential for neuronal survival following mitochondrial dysfunction.	STK11 AIFM1	4.91e-06	3	45	2	23187960
Pubmed	RapGAPs in brain: multipurpose players in neuronal Rap signalling.	SIPA1L2 SIPA1L1	4.91e-06	3	45	2	20576033
Pubmed	RNA interference characterization of proteins discovered by proteomic analysis of pancreatic cancer reveals function in cell growth and survival.	CD46 F3	9.81e-06	4	45	2	21934552
Pubmed	Leptin-induced epithelial-mesenchymal transition in breast cancer cells requires β-catenin activation via Akt/GSK3- and MTA1/Wnt1 protein-dependent pathways.	STK11 MTA1	3.42e-05	7	45	2	22270359
Pubmed	A new family of mouse homeo box-containing genes: molecular structure, chromosomal location, and developmental expression of Hox-7.1.	MSX1 GUSB	3.42e-05	7	45	2	2565278
Pubmed	Effect of angiogenesis inhibition by Id loss and the contribution of bone-marrow-derived endothelial cells in spontaneous murine tumors.	FGFR1 ITGB4	3.42e-05	7	45	2	14585355
Pubmed	Understanding the cell fate and behavior of progenitors at the origin of the mouse cardiac mitral valve.	MSX1 ACLY	5.86e-05	9	45	2	38198889
Pubmed	SOX11 and SOX4 drive the reactivation of an embryonic gene program during murine wound repair.	FBLIM1 ITGB4	5.86e-05	9	45	2	31492871
Pubmed	Fibroblast growth factor receptors (FGFRs) and their roles in limb development.	MSX1 FGFR1	5.86e-05	9	45	2	10199963
Pubmed	Association between genetic variants of reported candidate genes or regions and risk of cleft lip with or without cleft palate in the polish population.	MSX1 FGFR1	7.32e-05	10	45	2	20544801
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	USP7 ICE1 FGFR1 PRKRIP1 SIPA1L2 SZT2 ITGB4 SPEG	7.68e-05	1105	45	8	35748872
Pubmed	RUFY1 binds Arl8b and mediates endosome-to-TGN CI-M6PR retrieval for cargo sorting to lysosomes.	USP7 SRP72 HSPBP1 AIFM1 ACLY	8.12e-05	344	45	5	36282215
Pubmed	Synergistic activities of alpha3 and alpha6 integrins are required during apical ectodermal ridge formation and organogenesis in the mouse.	MSX1 ITGB4	1.07e-04	12	45	2	10433923
Pubmed	Mouse rump-white mutation associated with an inversion of chromosome 5.	MSX1 GUSB	1.07e-04	12	45	2	8043948
Pubmed	Promoting anti-tumor immunity by targeting TMUB1 to modulate PD-L1 polyubiquitination and glycosylation.	IPO8 AIFM1 ACLY	1.13e-04	72	45	3	36376293
Pubmed	Gene-trap mutagenesis using Mol/MSM-1 embryonic stem cells from MSM/Ms mice.	HMBOX1 MTA1 FBLIM1	1.23e-04	74	45	3	23604909
Pubmed	Cytoplasmic plaque formation in hemidesmosome development is dependent on SoxF transcription factor function.	MSX1 ITGB4	1.27e-04	13	45	2	22962592
Pubmed	Distinct Requirements for FGFR1 and FGFR2 in Primitive Endoderm Development and Exit from Pluripotency.	MSX1 FGFR1	1.47e-04	14	45	2	28552557
Pubmed	Opposing Fgf and Bmp activities regulate the specification of olfactory sensory and respiratory epithelial cell fates.	MSX1 FGFR1	1.47e-04	14	45	2	20392740
Pubmed	Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.	SENP6 SZT2 AIFM1 SIPA1L1	1.53e-04	208	45	4	33230847
Pubmed	Mapping the MOB proteins' proximity network reveals a unique interaction between human MOB3C and the RNase P complex.	USP7 SRP72 MTA1 ACLY SIPA1L1	1.62e-04	399	45	5	37536630
Pubmed	FGF signaling is strictly required to maintain early telencephalic precursor cell survival.	MSX1 FGFR1	1.94e-04	16	45	2	19542358
Pubmed	Inhibition of Wnt signaling by Wise (Sostdc1) and negative feedback from Shh controls tooth number and patterning.	MSX1 FGFR1	2.20e-04	17	45	2	20724449
Pubmed	In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators.	USP7 SRP72 HSPBP1 MTA1 IPO8 AIFM1 SPEG	2.33e-04	971	45	7	33306668
Pubmed	Stabilization of the methyl-CpG binding protein ZBTB38 by the deubiquitinase USP9X limits the occurrence and toxicity of oxidative stress in human cells.	USP7 HSPBP1 IPO8	2.58e-04	95	45	3	29490077
Pubmed	The protein interaction landscape of the human CMGC kinase group.	USP7 ICE1 FGFR1 SIPA1L2 ARPC1B SIPA1L1	2.62e-04	695	45	6	23602568
Pubmed	FGF signaling regulates development by processes beyond canonical pathways.	MSX1 FGFR1	2.76e-04	19	45	2	33184218
Pubmed	Abnormal Wnt and PI3Kinase signaling in the malformed intestine of lama5 deficient mice.	MSX1 ITGB4	2.76e-04	19	45	2	22666383
Pubmed	Delineating a conserved genetic cassette promoting outgrowth of body appendages.	MSX1 FGFR1	3.06e-04	20	45	2	23358455
Pubmed	CHFR regulates chemoresistance in triple-negative breast cancer through destabilizing ZEB1.	USP7 IPO8 AIFM1	3.09e-04	101	45	3	34462429
Pubmed	MT1-MMP inactivates ADAM9 to regulate FGFR2 signaling and calvarial osteogenesis.	MSX1 FGFR1	3.38e-04	21	45	2	22632802
Pubmed	FGFR1 function at the earliest stages of mouse limb development plays an indispensable role in subsequent autopod morphogenesis.	MSX1 FGFR1	3.38e-04	21	45	2	16207751
Pubmed	Fgfr1 regulates patterning of the pharyngeal region.	MSX1 FGFR1	3.72e-04	22	45	2	12514106
Pubmed	Altered gene expression pattern in the fatty liver dystrophy mouse reveals impaired insulin-mediated cytoskeleton dynamics.	F3 GUSB	3.72e-04	22	45	2	10438476
Pubmed	Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus.	HMBOX1 MSX1 NR1H3 FBLIM1	3.73e-04	263	45	4	20932939
Pubmed	Perinatal deiodinase 2 expression in hepatocytes defines epigenetic susceptibility to liver steatosis and obesity.	NR1H3 ACLY	4.07e-04	23	45	2	26508642
Pubmed	Runx2 mediates FGF signaling from epithelium to mesenchyme during tooth morphogenesis.	MSX1 FGFR1	4.44e-04	24	45	2	15136142
Pubmed	Transcriptome analysis of human gastric cancer.	NR1H3 TMC4 HSPBP1 FBLIM1 F3 DERPC	4.57e-04	772	45	6	16341674
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	USP7 SRP72 IPO8 AIFM1 NDUFB10 GUSB ARPC1B SIPA1L1	4.65e-04	1440	45	8	30833792
Pubmed	Type 1 fibroblast growth factor receptor in cranial neural crest cell-derived mesenchyme is required for palatogenesis.	MSX1 FGFR1	5.22e-04	26	45	2	23754280
Pubmed	Vti1b promotes TRPV1 sensitization during inflammatory pain.	AIFM1 NDUFB10 ACLY	6.03e-04	127	45	3	30335684
Pubmed	Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes.	USP7 SENP6	6.06e-04	28	45	2	22118674
Pubmed	Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.	HMBOX1 FGFR1 MTA1 FBLIM1 SIPA1L1	6.27e-04	536	45	5	15840001
Pubmed	Exchangeable gene trap using the Cre/mutated lox system.	HMBOX1 FGFR1 MTA1 FBLIM1 SIPA1L1	6.38e-04	538	45	5	10512203
Pubmed	Phase transition specified by a binary code patterns the vertebrate eye cup.	MSX1 FGFR1	7.43e-04	31	45	2	34757798
Pubmed	Liver X receptors and oxysterols promote ventral midbrain neurogenesis in vivo and in human embryonic stem cells.	MSX1 NR1H3	7.43e-04	31	45	2	19796621
Pubmed	The ubiquitin ligase mLin41 temporally promotes neural progenitor cell maintenance through FGF signaling.	MSX1 FGFR1	7.43e-04	31	45	2	22508726
Pubmed	DNA-binding specificities of human transcription factors.	HMBOX1 TBX21	7.43e-04	31	45	2	23332764
Pubmed	The non-canonical BMP and Wnt/β-catenin signaling pathways orchestrate early tooth development.	MSX1 FGFR1	7.92e-04	32	45	2	25428587
Pubmed	MiR-302/367 regulate neural progenitor proliferation, differentiation timing, and survival in neurulation.	MSX1 FGFR1	7.92e-04	32	45	2	26441343
Pubmed	TRIP12 promotes small-molecule-induced degradation through K29/K48-branched ubiquitin chains.	USP7 JMJD6	8.43e-04	33	45	2	33567268
Pubmed	Lrp4 and Wise interplay controls the formation and patterning of mammary and other skin appendage placodes by modulating Wnt signaling.	MSX1 FGFR1	8.94e-04	34	45	2	23293290
Pubmed	Twist function is required for the morphogenesis of the cephalic neural tube and the differentiation of the cranial neural crest cells in the mouse embryo.	MSX1 FGFR1	8.94e-04	34	45	2	12086465
Pubmed	An FGF autocrine loop initiated in second heart field mesoderm regulates morphogenesis at the arterial pole of the heart.	MSX1 FGFR1	9.48e-04	35	45	2	18832392
Pubmed	Transcriptional analysis of cleft palate in TGFβ3 mutant mice.	MSX1 ITGB4	9.48e-04	35	45	2	32913205
Pubmed	Retinoic acid receptors are required for skeletal growth, matrix homeostasis and growth plate function in postnatal mouse.	MSX1 MTA1	9.48e-04	35	45	2	19389355
Pubmed	Genetic variants in COL2A1, COL11A2, and IRF6 contribute risk to nonsyndromic cleft palate.	MSX1 FGFR1	1.00e-03	36	45	2	20672350
Pubmed	Disease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation.	HSPBP1 AIFM1	1.00e-03	36	45	2	35379950
Pubmed	GLI3 constrains digit number by controlling both progenitor proliferation and BMP-dependent exit to chondrogenesis.	MSX1 FGFR1	1.06e-03	37	45	2	22465667
Pubmed	Cubilin, a high affinity receptor for fibroblast growth factor 8, is required for cell survival in the developing vertebrate head.	MSX1 FGFR1	1.06e-03	37	45	2	23592779
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	USP7 SRP72 ITGB4 NDUFB10 ACLY ARPC1B SIPA1L1	1.08e-03	1257	45	7	36526897
Pubmed	A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.	USP7 HSPBP1 IPO8 ITGB4 AIFM1	1.10e-03	608	45	5	16713569
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	USP7 SENP6 FMN2 JCAD MTA1 SIPA1L1 PLA2G3	1.23e-03	1285	45	7	35914814
Cytoband	17q25	JMJD6 ITGB4	7.11e-04	39	46	2	17q25
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	MYOM2 FGFR1 SPEG	1.73e-03	161	27	3	593
GeneFamily	ADAM metallopeptidase domain containing\|CD molecules	CD46 FGFR1 F3 ITGB4	2.62e-03	394	27	4	471
Drug	Enilconazole [35554-44-0]; Down 200; 13.4uM; PC3; HT_HG-U133A	USP7 SENP6 JCAD ZNF74 MTA1 ITGB4	1.57e-06	197	42	6	5113_DN
Drug	nordihydroguaiaretic acid; Down 200; 1uM; PC3; HT_HG-U133A	USP7 FGFR1 MTA1 IPO8 F3 SPEG	1.62e-06	198	42	6	4447_DN
Drug	Sulpiride [15676-16-1]; Down 200; 11.8uM; PC3; HG-U133A	CD46 FGFR1 HSPBP1 PRKRIP1 ACLY SIPA1L1	1.62e-06	198	42	6	1887_DN
Drug	pT-T-A	F3 ACLY	3.32e-06	2	42	2	CID000040153
Drug	MBTFA	F3 GUSB	9.95e-06	3	42	2	CID000069635
Drug	Cephaeline dihydrochloride heptahydrate [6487-30-5]; Down 200; 6uM; PC3; HT_HG-U133A	USP7 JCAD CD46 FGFR1 MTA1	1.91e-05	179	42	5	4651_DN
Drug	NSC-269575	F3 GUSB	1.99e-05	4	42	2	CID000082614
Drug	0317956-0000 [391210-11-0]; Down 200; 1uM; PC3; HT_HG-U133A	CD46 MTA1 IPO8 ITGB4 ACLY	2.67e-05	192	42	5	4334_DN
Drug	Clomipramine hydrochloride [17321-77-6]; Down 200; 11.4uM; MCF7; HT_HG-U133A	USP7 SENP6 NR1H3 FGFR1 PCIF1	2.88e-05	195	42	5	6825_DN
Drug	Cefuroxime sodium salt [56238-63-2]; Down 200; 9uM; HL60; HT_HG-U133A	SENP6 ZNF74 IPO8 JMJD6 PCIF1	3.02e-05	197	42	5	2526_DN
Drug	Androsterone [53-41-8]; Up 200; 13.8uM; PC3; HT_HG-U133A	MTA1 IPO8 SZT2 ITGB4 SPEG	3.02e-05	197	42	5	4635_UP
Drug	Phensuximide [86-34-0]; Down 200; 21.2uM; PC3; HT_HG-U133A	SENP6 CD46 IPO8 F3 ITGB4	3.02e-05	197	42	5	5097_DN
Drug	Chlorhexidine [55-56-1]; Down 200; 8uM; MCF7; HT_HG-U133A	ZNF74 IPO8 F3 ITGB4 PLA2G3	3.10e-05	198	42	5	1525_DN
Drug	Benserazide hydrochloride [14919-77-8]; Down 200; 13.6uM; MCF7; HT_HG-U133A	SENP6 ZNF74 CD46 FGFR1 F3	3.10e-05	198	42	5	6482_DN
Drug	Azacyclonol [115-46-8]; Down 200; 15uM; MCF7; HT_HG-U133A	SENP6 ZNF74 FGFR1 IPO8 F3	3.10e-05	198	42	5	5398_DN
Drug	Simvastatin [79902-63-9]; Down 200; 9.6uM; MCF7; HT_HG-U133A	USP7 STK11 FGFR1 IPO8 ITGB4	3.25e-05	200	42	5	3340_DN
Drug	1-aminoglycerol	F3 GUSB	3.31e-05	5	42	2	CID000073561
Drug	phenyl glucuronide	AIFM1 GUSB	4.96e-05	6	42	2	CID000087235
Drug	L-phosphatidyl-glycerol	F3 GUSB	4.96e-05	6	42	2	CID000454706
Drug	8-OH-DPAT	CD46 JMJD6 GUSB RD3	6.38e-05	117	42	4	CID000001220
Drug	Agent QL	MTA1 JMJD6 GUSB	7.33e-05	44	42	3	CID000170325
Disease	retinal detachment (biomarker_via_orthology)	FGFR1 AIFM1	7.77e-05	9	44	2	DOID:5327 (biomarker_via_orthology)
Disease	Oligodontia	MSX1 FGFR1	1.42e-04	12	44	2	C4082304
Disease	level of Phosphatidylinositol (16:0_18:1) in blood serum	USP7 TMC4	1.42e-04	12	44	2	OBA_2045152
Disease	Hypodontia	MSX1 FGFR1	1.96e-04	14	44	2	C0020608
Disease	cleft lip (is_implicated_in)	MSX1 FGFR1	2.25e-04	15	44	2	DOID:9296 (is_implicated_in)
Disease	acute lymphoblastic leukemia (is_marker_for)	CD46 F3	1.18e-03	34	44	2	DOID:9952 (is_marker_for)
Disease	obesity (biomarker_via_orthology)	STK11 NR1H3 FGFR1	1.38e-03	147	44	3	DOID:9970 (biomarker_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
PWRKPTVPEPVMSTP	C2orf78	856	A6NCI8
PELPYMRPPLSKELW	AIFM1	166	O95831
VEERPAPTPWGSKMP	ARPC1B	176	O15143
PRDRPRSPGMDCKPW	FAM47DP	6	A6NHR8
KKRMPTEGPWPADAP	FAM220BP	31	B1ANY3
DRLRVTPWPMAPDPH	NR1H3	231	Q13133
EKRRPPYRWFVMGPP	JMJD6	166	Q6NYC1
MEPPGRRECPFPSWR	CD46	1	P15529
EPQPRMWVPESPVCR	JCAD	891	Q9P266
LSMRPAPIPIEDPEW	HMBOX1	236	Q6NT76
MPDSWDKDVYPEPPR	NDUFB10	1	O96000
PQTDMRPEKLKEPWP	ITGB4	181	P16144
VPIPEKMSEWAPRPP	PRKRIP1	46	Q9H875
KMSEWAPRPPPEFVR	PRKRIP1	51	Q9H875
MKEPRIFPRERPTPW	DERPC	1	P0CG12
MSPWPEDPRRASPPD	ICE1	1681	Q9Y2F5
PEWREPPTPALTRME	PCIF1	586	Q9H4Z3
PNRMPVAPYWTSPEK	FGFR1	146	P11362
RPLWESGPTVDMPVP	GUSB	66	P08236
RPWEAPAPMKTPEAG	FBLIM1	41	Q8WUP2
EVWSMPVPVERRPSP	KATNA1	96	O75449
WPRPRRYVEPPEMIG	GAGE13	11	Q4V321
PIEPCRPMKPLYWTR	FMN2	1286	Q9NZ56
PMRKRQLPASFWEEP	FAM181A	191	Q8N9Y4
KNMVTQYWPDREPPP	IPO8	61	O15397
DPPPEPMSEERRQWL	HSPBP1	61	Q9NZL4
YVAMAPWPLEPEGPR	SZT2	441	Q5T011
REFMVAFPDPARPPW	TMEM151B	281	Q8IW70
SPEKPERTPWMQSPR	MSX1	136	P28360
ERTPWMQSPRFSPPP	MSX1	141	P28360
VPKMGVRARIADWPP	SIPA1L1	71	O43166
VPKMGVRARVSEWPP	SIPA1L2	71	Q9P2F8
PGVRPEETMPWIRSP	TEX49	91	A0A1B0GTD5
PIPPSPDTKDRWRSM	STK11	321	Q15831
DTPPPLRSWSMPEFR	RD3	176	Q7Z3Z2
PPVKRRRMNWIDAPD	MTA1	641	Q13330
YDPKVTPDPERWLPM	SRP72	566	O76094
PPPALLFPMDPRWDR	TEX45	61	Q8NA69
ERQPWPSEPLRGPMS	PLA2G3	471	Q9NZ20
VPPPTVPMDYSWARE	ACLY	816	P53396
QVRSPPLEPPKESMW	PNMA5	141	Q96PV4
EFPEPGETWPRTPTM	SPEG	836	Q15772
DPHPSRELPWPMQAR	TMC4	86	Q7Z404
ANWFPPPRMRTKREE	SENP6	1056	Q9GZR1
METPAWPRVPRPETA	F3	1	P13726
PKPKRWRAAEMESPP	NPIPB2	336	A6NJ64
WRAAEMESPPEPKRR	NPIPB2	341	A6NJ64
PAPAMVWDVPVEEFP	ZNF74	166	Q16587
PWKIMVMPRFYPDRP	USP7	96	Q93009
SWFRPMRTLPMEPGP	TBX21	446	Q9UL17
WEPPTPRGKDPLMYF	MYOM2	531	P54296