Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionretinoic acid-responsive element binding

MYT1L RARA

1.33e-047512GO:0044323
GeneOntologyMolecularFunctionoxidized purine DNA binding

BLM MSH6

2.84e-0410512GO:0032357
GeneOntologyMolecularFunctionoxidized DNA binding

BLM MSH6

3.47e-0411512GO:0032356
DomainPLAC

ADAMTS19 ADAMTSL1

6.51e-0414512PF08686
DomainPLAC

ADAMTS19 ADAMTSL1

1.21e-0319512PS50900
DomainPLAC

ADAMTS19 ADAMTSL1

1.21e-0319512IPR010909
DomainPWWP

MSH6 HDGFL1

1.35e-0320512SM00293
DomainPentatricopeptide_repeat

LRPPRC NCAPG2

1.78e-0323512IPR002885
DomainPWWP

MSH6 HDGFL1

1.78e-0323512PF00855
DomainPWWP_dom

MSH6 HDGFL1

1.78e-0323512IPR000313
DomainPWWP

MSH6 HDGFL1

1.94e-0324512PS50812
DomainPeptidase_M12B_ADAM-TS

ADAMTS19 ADAMTSL1

1.94e-0324512IPR013273
DomainPept_cys_AS

CAPN3 DNAH8

2.64e-0328512IPR000169
DomainEF-hand_8

CAPN3 RYR2

3.88e-0334512PF13833
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

RLF LRPPRC RIC8B ANK3 HECTD4 NAIP NTN1 FNBP1L ZHX2 PBX3 USP15 VPS13B

1.53e-061489521228611215
Pubmed

The Bloom's syndrome helicase interacts directly with the human DNA mismatch repair protein hMSH6.

BLM MSH6

2.19e-06252212974384
Pubmed

Childhood intelligence is heritable, highly polygenic and associated with FNBP1L.

LRPPRC FNBP1L

1.31e-05452223358156
Pubmed

The inhibitory glutathione transferase M2-2 binding site is located in divergent region 3 of the cardiac ryanodine receptor.

GSTM2 RYR2

1.31e-05452222406107
Pubmed

Components of the CCR4-NOT complex function as nuclear hormone receptor coactivators via association with the NRC-interacting Factor NIF-1.

RARA CCR4

2.19e-05552218180299
Pubmed

The mismatch DNA repair heterodimer, hMSH2/6, regulates BLM helicase.

BLM MSH6

2.19e-05552215064730
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

DAB2IP MON2 SORBS2 ZHX2 USP15 VPS13B

3.20e-0540752612693553
Pubmed

PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression.

SETD1A NCAPG2

3.28e-05652220622854
Pubmed

Rb/E2F regulates expression of neogenin during neuronal migration.

RGMA NTN1

4.58e-05752221059867
Pubmed

Mitochondrial Raf1 Regulates Glutamine Catabolism.

LRPPRC ADAMTSL1 ANK3 CAPN3 RPS25

7.11e-0528852538496616
Pubmed

SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint.

BLM MSH6

1.20e-041152211877377
Pubmed

Chemical Crosslinking Mass Spectrometry Analysis of Protein Conformations and Supercomplexes in Heart Tissue.

LRPPRC SORBS2 ANK3 VPS13B RYR2

1.36e-0433152529199018
Pubmed

BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures.

BLM MSH6

1.43e-041252210783165
Pubmed

RGMB and neogenin control cell differentiation in the developing olfactory epithelium.

RGMA NTN1

1.69e-041352227143755
Pubmed

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.

MYT1L DAB2IP ILF2 ANK3 P2RX7 DCAF17 MTO1 VPS13B

1.93e-04108452811544199
Pubmed

Regulation of ubiquitin-proteasome system-mediated Tip110 protein degradation by USP15.

LRPPRC USP15

2.60e-041652224984263
Pubmed

Large scale identification of human hepatocellular carcinoma-associated antigens by autoantibodies.

PHF20 C9orf78

2.60e-041652212097419
Pubmed

PTENα and PTENβ promote carcinogenesis through WDR5 and H3K4 trimethylation.

MSH6 LRPPRC ILF2 RPS25

3.16e-0421752431685992
Pubmed

Identification of FMRP target mRNAs in the developmental brain: FMRP might coordinate Ras/MAPK, Wnt/β-catenin, and mTOR signaling during corticogenesis.

MYT1L ANK3

3.30e-041852233323119
Pubmed

PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex.

BLM SETD1A

3.30e-041852217500065
Pubmed

Ebf1 controls early cell differentiation in the embryonic striatum.

RARA NTN1

3.30e-041852210556054
Pubmed

Upregulation of RIN3 induces endosomal dysfunction in Alzheimer's disease.

MSH6 LRPPRC ILF2 RPS25 FNBP1L

4.00e-0441852532552912
Pubmed

QKI is a critical pre-mRNA alternative splicing regulator of cardiac myofibrillogenesis and contractile function.

ANK3 RYR2

4.09e-042052233397958
Pubmed

TNIP2 is a Hub Protein in the NF-κB Network with Both Protein and RNA Mediated Interactions.

SETD1A LRPPRC ILF2 C9orf78 DHX32 RPS25 PBX3

4.26e-0492252727609421
Pubmed

The atypical homeoprotein Pbx1a participates in the axonal pathfinding of mesencephalic dopaminergic neurons.

NTN1 PBX3

4.97e-042252222748019
Pubmed

A proteomic analysis of human bile.

FCGBP HPX

4.97e-042252215084671
Pubmed

Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.

BLM SETD1A MSH6 HECTD4 USP15

5.05e-0444052534244565
Pubmed

Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

ADAMTSL1 USP15 VPS13B

5.31e-041055239628581
Pubmed

Radial glia fibers translate Fgf8 morphogenetic signals to generate a thalamic nuclear complex protomap in the mantle layer.

NTN1 BTBD3

5.44e-042352230470893
Pubmed

Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System.

MYT1L RARA NTN1 PBX3

5.46e-0425152429031500
Pubmed

Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome.

DAB2IP LRPPRC SORBS2 ANK3

5.46e-0425152427507650
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

DAB2IP LRPPRC SORBS2 ILF2 ANK3 P2RX7 HECTD4

5.52e-0496352728671696
Pubmed

DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.

BLM SETD1A ILF2 ZHX2 NCAPG2

5.76e-0445352529656893
Pubmed

Synergistic integration of Netrin and ephrin axon guidance signals by spinal motor neurons.

RGMA NTN1

5.93e-042452226633881
Pubmed

USP10 regulates B cell response to SARS-CoV-2 or HIV-1 nanoparticle vaccines through deubiquitinating AID.

MSH6 USP15

5.93e-042452234983926
Pubmed

Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking miRNA-1-2.

NTN1 ARHGAP20

6.43e-042552217397913
Pubmed

USP7 Regulates Cytokinesis through FBXO38 and KIF20B.

BLM FBXO38 NCAPG2

7.09e-0411652330804394
Pubmed

Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease.

P2RX7 HYDIN

7.51e-042752223144326
Pubmed

Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair.

GSTM2 MSH6 LRPPRC ILF2 DHX32 RPS25 ARHGAP20 USP15

7.73e-04133552829229926
Pubmed

The TIP60 Complex Is a Conserved Coactivator of HIF1A.

MON2 MSH6 LRPPRC

7.83e-0412052327320910
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

BLM RLF SETD1A MSH6 LRPPRC ILF2 RPS25 NCAPG2

8.43e-04135352829467282
Pubmed

Genome-wide association study of smoking behaviours in patients with COPD.

MSH6 CXCL14

8.67e-042952221685187
Pubmed

MBD5 and MBD6 stabilize the BAP1 complex and promote BAP1-dependent cancer.

GSTM2 LRPPRC ILF2 RPS25

9.00e-0428752436180891
Pubmed

TRAF4 promotes TGF-β receptor signaling and drives breast cancer metastasis.

ILF2 USP15

9.29e-043052223973329
Pubmed

Genome-wide association study of periodontal pathogen colonization.

DAB2IP FBXO38

9.92e-043152222699663
Pubmed

c-Maf is required for the development of dorsal horn laminae III/IV neurons and mechanoreceptive DRG axon projections.

NTN1 PBX3

1.06e-033252222514301
Pubmed

Primary Ciliary Dyskinesia

DNAH8 HYDIN

1.06e-033252220301301
Pubmed

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.

BLM MSH6 LRPPRC SORBS2 ILF2 HECTD4 RPS25

1.09e-03108252738697112
Pubmed

Immunoprecipitation and mass spectrometry defines an extensive RBM45 protein-protein interaction network.

LRPPRC ILF2 RPS25

1.12e-0313652326979993
Pubmed

Genetic variation in genes interacting with BRCA1/2 and risk of breast cancer in the Cypriot population.

BLM MSH6

1.12e-033352219714462
Pubmed

Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry.

ILF2 RPS25

1.19e-033452211101529
Pubmed

Pioneering function of Isl1 in the epigenetic control of cardiomyocyte cell fate.

PBX3 RYR2

1.19e-033452231024170
Pubmed

Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.

MSH6 LRPPRC ILF2 ANK3 RPS25 HYDIN

1.26e-0380752630575818
Pubmed

L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms.

P2RX7 CXCL14 RYR2

1.30e-0314352320424473
Pubmed

Nuclear Functions of Nucleolin through Global Proteomics and Interactomic Approaches.

MSH6 ILF2 RPS25

1.35e-0314552327049334
Pubmed

Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability.

BLM MSH6 USP15

1.40e-0314752329576527
Pubmed

Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.

DAB2IP MON2 LRPPRC SORBS2 ANK3 USP15 RYR2

1.47e-03113952736417873
Pubmed

Loss of Rearranged L-Myc Fusion (RLF) results in defects in heart development in the mouse.

RLF RARA

1.49e-033852227930960
InteractionSGSM2 interactions

RGMA ILF2 RPS25 FNBP1L

1.34e-0632524int:SGSM2
Cytoband15q26.1

BLM RGMA

1.73e-035452215q26.1
CytobandEnsembl 112 genes in cytogenetic band chr11q23

RPS25 ARHGAP20 JAML

2.02e-03220523chr11q23
Cytoband11q23.3

RPS25 JAML

3.58e-037852211q23.3
GeneFamilyPWWP domain containing

MSH6 HDGFL1

8.68e-04223621147
CoexpressionPEREZ_TP53_TARGETS

DAB2IP MON2 SORBS2 ANK3 P2RX7 CAPN3 HECTD4 CXCL14 NTN1 USP15 VPS13B ZNF71

3.05e-0612015212M4391
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_DN

BLM RLF MSH6 LRPPRC PHF20 FNBP1L ZHX2 PBX3 USP15 VPS13B

5.97e-068565210M4500
CoexpressionKASLER_HDAC7_TARGETS_1_UP

RARA P2RX7 CAPN3 CCR4 PBX3

3.93e-05192525M2317
CoexpressionKASLER_HDAC7_TARGETS_1_UP

RARA P2RX7 CAPN3 CCR4 PBX3

4.13e-05194525MM910
CoexpressionGSE40274_FOXP3_VS_FOXP3_AND_GATA1_TRANSDUCED_ACTIVATED_CD4_TCELL_DN

DCAF17 ARHGAP20 ZHX2 TEX35 DNAH8

4.67e-05199525M9180
CoexpressionGSE13522_WT_VS_IFNAR_KO_SKING_T_CRUZI_Y_STRAIN_INF_UP

GPR15 P2RX7 CAPN3 CCR4 ARHGAP20

4.78e-05200525M2933
ToppCellCOVID-19-kidney-Technical/muscle_(Mes)|kidney / Disease (COVID-19 only), tissue and cell type

MYT1L ADAMTSL1 DNAH8 RYR2

3.56e-051595245335cbcdeaf2bbd0268bbfe0e45c8c0d288e640d
ToppCellFetal_29-31_weeks-Epithelial-club_cell-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ADAMTSL1 ANK3 NTN1 ZNF730

3.83e-051625245c9bc3c3857a99d8a3caf359a7eb279ce9cc1c81
ToppCellAdult-Epithelial-lung_goblet_cell-D122|Adult / Lineage, Cell type, age group and donor

ADAMTSL1 SORBS2 FCGBP NTN1

4.31e-051675246efbb2ef6adc8da5dd67210969f825f5cc8ed022
ToppCell356C-Fibroblasts-Fibroblast-E-|356C / Donor, Lineage, Cell class and subclass (all cells)

ADAMTSL1 CXCL14 NTN1 ARHGAP20

5.53e-05178524a493a277d175e5e153410a745b26ebe2e0839ea0
ToppCell356C-Fibroblasts-Fibroblast-E|356C / Donor, Lineage, Cell class and subclass (all cells)

ADAMTSL1 CXCL14 NTN1 ARHGAP20

5.53e-05178524371218babddfd3d8a7bb82a46ce65327ee3fcf12
ToppCelldroplet-Heart-4Chambers-21m-Mesenchymal-nan|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BLM RGMA SETD1A ARHGAP20

5.65e-05179524b44e2d53b82c3c141bfc6539054b19708200a0d9
ToppCelldroplet-Lung-30m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l25|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DAB2IP SORBS2 NTN1 HYDIN

6.16e-051835246f8f997ffc9eaebca2683de125b6069d07c07d26
ToppCellLPS_only|World / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

RLF ZHX2 USP15 VPS13B

6.42e-05185524a72ccb147ca505880e2da8f6a70b9d570464a691
ToppCell343B-Fibroblasts-Fibroblast-E-|343B / Donor, Lineage, Cell class and subclass (all cells)

RGMA RIC8B CXCL14 ARHGAP20

6.56e-051865241bac7825c2fe3e6cdff65026b09b9ccaa40fa27f
ToppCell343B-Fibroblasts-Fibroblast-E|343B / Donor, Lineage, Cell class and subclass (all cells)

RGMA RIC8B CXCL14 ARHGAP20

6.56e-0518652459db239f1864a5d4f1570c93219dbd7ac5b6db35
ToppCellLA-03._Atrial_Cardiomyocyte|World / Chamber and Cluster_Paper

SORBS2 ANK3 NTN1 RYR2

6.83e-051885246d249fe92d51a19da19ec14bb2262d394255d577
ToppCellNon-neuronal-Postmitotic-Red_blood_cells-Low_Quality|World / Primary Cells by Cluster

MYT1L SORBS2 HECTD4 FNBP1L

7.12e-0519052431cf1367db5c04242621f7c98a10d094bc519e31
ToppCell5'-GW_trimst-2-LargeIntestine-Mesenchymal-myocytic-myofibroblast_(RSPO2+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GSTM2 CXCL14 NTN1 PBX3

7.12e-05190524c01a8bfb9fbc0e6f37d7e9be25512eda63acabbc
ToppCellNon-neuronal-Postmitotic-Red_blood_cells|World / Primary Cells by Cluster

MYT1L SORBS2 HECTD4 FNBP1L

7.12e-05190524f0b82334375749d917e440c493f10340c52ea13c
ToppCellNon-neuronal-Postmitotic-Red_blood_cells-Low_Quality-14|World / Primary Cells by Cluster

MYT1L SORBS2 HECTD4 FNBP1L

7.12e-05190524feadd834d843f952aa7ced93899fd1f0868743df
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-4M-Neuronal-ventral_progenitors_and_neurons_1|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.

MYT1L ANK3 PBX3 RYR2

7.12e-051905246e92c78799f34b31d098854503c796edb0dc7f80
ToppCellfacs-Mammary_Gland-Mammary_Gland-21m-Epithelial-luminal_progenitor_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SORBS2 FCGBP NTN1 DHX32

7.12e-051905240bad41d19dc515e6bc61e699f4d56664cf2e72fd
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Meis2-Meis2_Adamts19|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ADAMTS19 PBX3 HYDIN

7.23e-0569523130b1a56afe6aee01cde56cb983cbc2c41861bb4
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Meis2|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ADAMTS19 PBX3 HYDIN

7.23e-05695236568fcefcc0dca211f2acf6e4066f795489e758d
ToppCellLA-03._Atrial_Cardiomyocyte|LA / Chamber and Cluster_Paper

SORBS2 ANK3 NTN1 RYR2

7.27e-051915245d1b674eb7703830b7ce8bbeac3363cabd0e6ae9
ToppCellChildren_(3_yrs)-Epithelial-club_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

ADAMTSL1 SORBS2 ANK3 NTN1

7.27e-0519152423776c7302cead3881b39127398f3b3e0d27885e
ToppCellCV-Severe-5|Severe / Virus stimulation, Condition and Cluster

GPR15 CCR4 RPS25 JAML

7.27e-05191524d04f93fc85c882260ca4d5b4768504fbf8a47984
ToppCelldroplet-Lung-1m-Endothelial-venous_endothelial|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

GSTM2 SORBS2 NTN1 ARHGAP20

7.41e-051925241990dc8a81594018a5bf596be99d0b5f0af0f58f
ToppCelldroplet-Lung-1m-Endothelial-venous_endothelial-vein_endothelial_cell-vein_endothelial_cell|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

GSTM2 SORBS2 NTN1 ARHGAP20

7.41e-05192524845cc9c18b4436b07dd3ce7980052683937546d2
ToppCelldroplet-Lung-1m-Endothelial-venous_endothelial-vein_endothelial_cell|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

GSTM2 SORBS2 NTN1 ARHGAP20

7.41e-05192524c72a082c93a8825adbfef37f889ba3a7052f201b
ToppCellEpithelial-club_cell|World / Lineage, Cell type, age group and donor

ADAMTSL1 ANK3 NTN1 FNBP1L

7.56e-051935242bdd09004fa433550958ec42ba4b06271a4aaf7c
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_myocytic-mes_proliferating_SM_(20)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

BLM CXCL14 NCAPG2 ZNF730

7.56e-05193524bbdfda6665941cfa1965418bb91ef9ff43b1326f
ToppCellCV-Mild-5|Mild / Virus stimulation, Condition and Cluster

GPR15 CCR4 RPS25 JAML

7.56e-051935242053f0f8083b3174e1b6f76d2d7089f59982565d
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_myocytic-mes_proliferating_SM_(20)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

BLM CXCL14 NCAPG2 ZNF730

7.56e-05193524516ea2c12bdc7a5dc676159d627e36f6abe13ef0
ToppCellCD8+_Memory_T_cell-CV-5|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster

GPR15 CCR4 RPS25 JAML

7.72e-051945245d644fe6da99b023eee100882ee7b71af4f3814a
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_myocytic-mes_proliferating_SM_(20)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

BLM CXCL14 NCAPG2 ZNF730

7.72e-05194524590a9d4f054e6a3685daf752c9354650fcc7d18a
ToppCellRA-03._Atrial_Cardiomyocyte|World / Chamber and Cluster_Paper

SORBS2 ANK3 NTN1 RYR2

7.72e-0519452489812fb164065041357bb37a3c2d87028ec3de4e
ToppCellRA-03._Atrial_Cardiomyocyte|RA / Chamber and Cluster_Paper

SORBS2 ANK3 NTN1 RYR2

7.72e-05194524c3535f7cc0076653c72db582047cff053c322397
ToppCell390C-Lymphocytic-CD4_T-cell|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

ANK3 CCR4 RPS25 JAML

7.72e-0519452476c4c3ba5f1bcc39d397c90db3513f5bea632b1b
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Myeloid_monocytic-non-classical_monocyte-Non-classical_monocytes-Non-classical_monocytes_L.1.2.2.2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

P2RX7 NAIP USP15 JAML

7.72e-05194524dfe0ece81922bfd7c6673726d3ea2365cbdb5513
ToppCellCV-Moderate-5|CV / Virus stimulation, Condition and Cluster

GPR15 CCR4 RPS25 JAML

7.87e-051955247a0bb304c659dd108b75d0c5d19eca5e63cf856d
ToppCellfacs-Mammary_Gland-Mammary_Gland-21m-Epithelial-luminal_epithelial_cell_of_mammary_gland|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SORBS2 FCGBP NTN1 DHX32

7.87e-0519552425703e3c2e0512ef12e7aa389fad3968c3f13905
ToppCellControl-Lymphoid-T|Lymphoid / Disease state, Lineage and Cell class

ANK3 CCR4 JAML RYR2

7.87e-051955246687e579582d7a239bee80846de0cf827a6f6a62
ToppCellCOPD-Multiplet-Multiplet|COPD / Disease state, Lineage and Cell class

SORBS2 ANK3 FNBP1L HYDIN

8.03e-05196524af4cdc61830685a888a1209826c23bcf54a43084
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22|PBMC_fresh-frozen / Compartment, severity and other cell annotations on 10x 3' data (130k)

RIC8B ANK3 CXCL14 RPS25

8.03e-05196524939c0d835e9700ac61df60884d3d86053b296410
ToppCellIPF-Lymphoid-T|Lymphoid / Disease state, Lineage and Cell class

ANK3 CCR4 JAML RYR2

8.03e-051965246e70c48a63d9673eb16b0847c1bd88eecc2f7a3c
ToppCellCOPD-Multiplet|COPD / Disease state, Lineage and Cell class

SORBS2 ANK3 FNBP1L HYDIN

8.03e-051965246d02d494196e3f857d53eea46d9419690d43beca
ToppCellCOPD-Lymphoid-T|Lymphoid / Disease state, Lineage and Cell class

ANK3 CCR4 JAML RYR2

8.03e-05196524c9bdd505c3ab380ed7b272aa518df31a0a706a06
ToppCellCOVID-19-lung-Macrophage_VCANhi_FCN1hi|lung / Disease (COVID-19 only), tissue and cell type

P2RX7 NAIP USP15 JAML

8.19e-05197524a0f8a992282a6d64890f5574c7c9741fcb38dadd
ToppCellCOVID-19-lung-Macrophage_VCANhi_FCN1hi|COVID-19 / Disease (COVID-19 only), tissue and cell type

P2RX7 NAIP USP15 JAML

8.35e-05198524ea34096bee852a7e996f097fa279381afa8f86ff
ToppCellbackground-Hepatic_Stellate_cells|World / Sample and Cell Type and Tumor Cluster (all cells)

ADAMTSL1 ANK3 HPX CXCL14

8.35e-0519852479f32f965aed6a10c5cb803173e3db7b32e07a91
ToppCellControl-PLT_4|Control / Disease Group and Platelet Clusters

FNBP1L USP15 VPS13B RYR2

8.35e-05198524387fd3037fd52e4d4c42de0588767e58af228b59
ToppCellParenchymal-NucSeq-Epithelial-Epi_airway_secretory-Secretory_Club|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ADAMTSL1 ANK3 NTN1 FNBP1L

8.35e-051985241408e02e053ad3406229bfe8189da03be6366e81
ToppCellParenchymal-NucSeq-Immune_Myeloid-Macrophage_other-Macro_AW_CX3CR1|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

BLM FCGBP JAML NCAPG2

8.35e-05198524732a43061d75bc5e1cf23f5056b72cd10c926668
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

MYT1L SORBS2 ANK3 RYR2

8.35e-051985240ff30edfd3c133a42e8cb96e1631a1143215f808
ToppCellParenchymal-NucSeq-Epithelial-Epi_airway_basal-Dividing_Basal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

BLM NTN1 LRRC43 ZNF730

8.35e-05198524d5e125f0c4f41b47d567568d0838adcca7655f6d
ToppCellmild-low-quality_cells|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

MON2 ANK3 USP15 VPS13B

8.51e-05199524f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCellCaecum-T_cell-Activated_CD4_T|T_cell / Region, Cell class and subclass

ANK3 NAIP CCR4 RPS25

8.51e-0519952413173cc4dcc8e856680372b0a4ad4f36afa892c1
ToppCell10x5'-bone_marrow-Lymphocytic_T_CD4-Teffector/EM_CD4|bone_marrow / Manually curated celltypes from each tissue

GPR15 ANK3 CCR4 RPS25

8.51e-05199524e0c01ce4301f8446d990180ec336593ef0148b38
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW10-Neuronal|GW10 / Sample Type, Dataset, Time_group, and Cell type.

MYT1L SORBS2 ANK3 FNBP1L

8.51e-05199524b2508bf591720830e8e3494b1337aab14539956d
ToppCell10x5'-Lung-Lymphocytic_T_CD4-Teffector/EM_CD4|Lung / Manually curated celltypes from each tissue

GPR15 ANK3 CCR4 RPS25

8.51e-0519952454b6a43e23826d507b8f1db578e589711d49bbfd
ToppCellTracheal-NucSeq|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations

MON2 ANK3 ZHX2 VPS13B

8.51e-0519952494b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCellTracheal|World / Cell types per location group and 10X technology with lineage, and cell group designations

SORBS2 FCGBP CXCL14 NTN1

8.68e-05200524682960e28542a3d6c119047cd0131941932cfdea
ToppCellNeuronal|World / cells hierarchy compared to all cells using T-Statistic

MYT1L SORBS2 ANK3 RYR2

8.68e-0520052448d801219bc771d6c7e151dc88ca4c179988de85
ToppCellBrain_organoid-organoid_Tanaka_cellReport-5w-Neuronal-Intermediate|5w / Sample Type, Dataset, Time_group, and Cell type.

SETD1A SORBS2 ANK3 HECTD4

8.68e-05200524c92e4fc0442404481fcac623d691dae6215b852d
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Upper_Layer|World / Primary Cells by Cluster

MYT1L ANK3 ARHGAP20 RYR2

8.68e-05200524db10f76938af553d1a2275bb02ef75dff3c3135b
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Upper_Layer-21|World / Primary Cells by Cluster

MYT1L ANK3 ARHGAP20 RYR2

8.68e-0520052430a3e4aee12ec1b5acdce90f86c9733c27a7f6fc
ToppCellBrain_organoid-organoid_Tanaka_cellReport-10w-Neuronal-Cortical_neuron|10w / Sample Type, Dataset, Time_group, and Cell type.

MYT1L ANK3 FNBP1L PBX3

8.68e-0520052468c90376e2779434e4ad8dc6dd3b44baa700e2f4
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW10-Neuronal|GW10 / Sample Type, Dataset, Time_group, and Cell type.

MYT1L SORBS2 ANK3 FNBP1L

8.68e-0520052404699d1149a143b96d6f292c0d70c4d3e6dfc611
ToppCellBrain_organoid-organoid_Tanaka_cellReport-10w-Neuronal|10w / Sample Type, Dataset, Time_group, and Cell type.

MYT1L ANK3 FNBP1L PBX3

8.68e-05200524979258173b82f37aeaaedd53b4a527da1dbe1b80
ToppCellCaecum-Dendritic_cell-cDC2|Dendritic_cell / Region, Cell class and subclass

RARA JAML

3.56e-0424522f2915c4e9cd1418778b3a6dcf4ba6e47ece6b0ac
ToppCellLV-03._Atrial_Cardiomyocyte|LV / Chamber and Cluster_Paper

SORBS2 ANK3 RYR2

3.72e-041205233b77bd0e3630cdd45001cecf5e47660a90ebc92e
ToppCellTCGA-Stomach-Primary_Tumor-Stomach_Adenocarcinoma-Stomach_Adenocarcinoma_-_NOS-7|TCGA-Stomach / Sample_Type by Project: Shred V9

SORBS2 ARHGAP20 RYR2

4.39e-041275235e4d110cc6e68cd8fc7a4771a65e6f8cd83e7721
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L5_PT-L5_PT_VISp_C1ql2_Cdh13|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

RGMA PBX3 JAML

5.36e-041365231f3000d5f105c87c80f8ae1dd2264bcd7f757a9c
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Crispld2_Htr2c|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

RGMA CXCL14 NTN1

6.58e-0414652347368f981180ca6a8c81a50f7f9430f12456f609
ToppCellLA-15._Ventricular_Cardiomyocyte_III|LA / Chamber and Cluster_Paper

SORBS2 ANK3 RYR2

6.72e-041475238970eb6b82589f39439c61a57d999661ec8342de
ToppCellCOVID-19-kidney-Technical/muscle|kidney / Disease (COVID-19 only), tissue and cell type

MYT1L DNAH8 RYR2

6.85e-041485230dbd87078f54ee1c2f8ec64e8bac9dfddb9c181e
ToppCellCOVID-19-kidney-Technical/muscle_(Mes)|COVID-19 / Disease (COVID-19 only), tissue and cell type

MYT1L ADAMTSL1 DNAH8

6.85e-04148523d6ac5972267254651dfbe16bb4e9a62228093cc7
ToppCellHealthy_donor-B_cell|Healthy_donor / disease group, cell group and cell class (v2)

FNBP1L DNAH8 ZNF730

7.40e-041525235768edfde8010324d8594815e73bbfba2c3045f3
ToppCellIIH-Treg|IIH / Condition, Cell_class and T cell subcluster

CCR4 USP15 DNAH8

7.54e-0415352317704e18833812fcf2a2727b1e3f8a9984ba5b59
ToppCellIIH-Treg-CD4_Treg|IIH / Condition, Cell_class and T cell subcluster

CCR4 USP15 DNAH8

7.69e-04154523d2211a892654b92decb208969040920f7ae8ba1e
ToppCelldroplet-Liver-Npc-21m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BLM DCAF17 CXCL14

7.83e-041555235d600e159738231d0607ea1a1ebd8510fc241b36
ToppCellInfluenza_Severe-CD4+_Tcm|World / Disease group and Cell class

ANK3 NTN1 RPS25

8.13e-04157523842ac087d3d51dba3a6b6937733b73a81aa15e1b
ToppCellSmart-seq2-lymph_node_(Smart-seq2)-lymphocytic-innate_lymphocytic-mature_NK_T_cell|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

GSTM2 LRRC43 JAML

8.28e-0415852341aff0a09a7087a67d0ac91028e4895df729289b
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c07-TYROBP|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)

MYT1L P2RX7 LRRC43

8.43e-04159523235ed12053b337aca5abc2ce8727332b4ae3f8ae
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTS19 HYDIN RYR2

8.58e-04160523c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCelldroplet-Liver-Npc-21m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BLM DCAF17 CXCL14

8.58e-0416052385205dc68369d3e04df3460c1f3861ee2dc242a9
ToppCell3'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SETD1A FNBP1L ZNF730

8.58e-04160523af84da18c85037f49f55e8958f00f12140226982
ToppCell3'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SETD1A FNBP1L ZNF730

8.58e-04160523f7ca98beaa24f9674d503588eb15d341c4135d77
ToppCell3'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SETD1A FNBP1L ZNF730

8.58e-04160523a76ad44b5f25f59d6b9333fb45f8bb96196a3090
ToppCell10x3'2.3-week_12-13-Hematopoietic-HSC/MPP_and_pro-LMPP|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

ADAMTSL1 ANK3 LRRC43

8.58e-0416052360fa1c717410aad7e8647703cb416cd7617cac29
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTS19 HYDIN RYR2

8.58e-0416052325c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCellChildren_(3_yrs)-Epithelial-lung_goblet_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

ADAMTSL1 SORBS2 NTN1

8.74e-041615232d63b279d9a5132e1c09b03930bf9039036d24a2
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Crispld2_Kcne4|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

RGMA CXCL14 NTN1

8.74e-04161523be77e99faf653480c166305df3a4e93db76f0dcb
ToppCell390C-Lymphocytic-NK_cells-NK_cell_D3|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

GSTM2 GPR15 CXCL14

8.74e-041615233e5a125a25d55bf27652f456239b00b315d54d91
ToppCell5'-GW_trimst-2-LargeIntestine-Mesenchymal-immature_mesenchymal_cell-Mesoderm_1_(HAND1+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ADAMTSL1 HDGFL1 CXCL14

8.74e-041615238aade4da418d280fec393a3032cc163909408a69
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

BLM NCAPG2 ZNF730

9.06e-041635233f434015c0cbefb31eeda133c34f75384c5f7e22
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c04-ANXA2|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

ANK3 CCR4 LRRC43

9.22e-041645238f3255d7f67890389a768453492243ea982eb38a
ToppCellTransplant_Alveoli_and_parenchyma-Epithelial-Ciliated_2|Transplant_Alveoli_and_parenchyma / Tissue, Lineage and Cell class of Lung Cells from 10X

GSTM2 HPX HYDIN

9.38e-04165523731147b4337fd0de4383dc8170b4f9ccd98caec6
ToppCellfacs-Marrow-T-cells-3m-Lymphocytic-Klrb1a/b/c(-)_NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RGMA GPR15 LRRC43

9.38e-04165523651d40eadb1b34de618af94c167f43635729d43f
ToppCell10x5'-bone_marrow-Lymphocytic_T_CD4-Tregs|bone_marrow / Manually curated celltypes from each tissue

GPR15 CCR4 DNAH8

9.38e-041655231ae1ad4e1fe19b6eefff0f9a03d58a384f169759
ToppCellLPS-antiTNF-Epithelial_airway-Club_cells|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SORBS2 ANK3 NTN1

9.55e-041665231df4bdf7c773cbfa6c93d7a901f9cd3f3fe07a3d
ToppCellLPS-antiTNF-Epithelial_airway-Club_cells-Airway|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SORBS2 ANK3 NTN1

9.55e-041665239628522e7af8f8edca733588a364ab2454ac5ca5
ToppCellmild-Lymphocytic-CD4_T_cells_3|Lymphocytic / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

CCR4 USP15 DNAH8

9.55e-04166523f8f8423423d72f0ea0266b59126abb27beb23094
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell_cycling-Cycling_Connecting_Tubule_Cell_S-high|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

BLM NCAPG2 ZNF730

9.71e-04167523108ae6221c6edc63c0ec42c42471b3a15a594043
Diseasechronic obstructive pulmonary disease, interleukin-8 measurement

P2RX7 HYDIN

1.68e-054502EFO_0000341, EFO_0004811
Diseasesusceptibility to mononucleosis measurement

MYT1L DNAH8 RYR2

2.22e-0469503EFO_0008403
Diseaseheart failure

RIC8B ADAMTSL1 HDGFL1 HECTD4

2.75e-04185504EFO_0003144
Diseasefrailty measurement

LRPPRC ANK3

6.96e-0423502EFO_0009885
Diseasepneumonia, COVID-19

RIC8B ADAMTSL1 VPS13B

9.40e-04113503EFO_0003106, MONDO_0100096
Diseasecaudate nucleus volume

MYT1L PBX3

1.19e-0330502EFO_0004830
Diseasewhite matter integrity

MYT1L NTN1 PBX3

1.41e-03130503EFO_0004641
Diseasedisease recurrence, unipolar depression, bipolar disorder, schizophrenia, sex interaction measurement

ADAMTS19 ACTRT2

1.44e-0333502EFO_0003761, EFO_0004952, EFO_0008343, MONDO_0004985, MONDO_0005090

Protein segments in the cluster

PeptideGeneStartEntry
KLSPKQYKIPCLEVD

NAIP

991

Q13075
EPRKLYEMPKCSKSE

DCAF17

81

Q5H9S7
IKKKLCYVALEPEKE

ACTRT2

216

Q8TDY3
LIDDKPYCAEKKATP

GPR15

176

P49685
PPVCYEIITLKTKKK

BTBD3

46

Q9Y2F9
LYESIPKPCTKEGIK

CCR4

21

P51679
YPKEKCSLFKPLDET

DHX32

311

Q7L7V1
DIACKCPKIKPLKKY

NTN1

541

O95631
KKEVPKPECSESYTL

RARA

166

P10276
EKCKYLTKPEPQIRK

ADAMTS19

956

Q8TE59
EAKDLPAKKKYLCEL

DAB2IP

221

Q5VWQ8
PYPSEEAKEELAKKC

PBX3

261

P40426
LSPKRLFPYKECKEK

HDGFL1

51

Q5TGJ6
LAKAVPEPLKKYTKC

MTO1

586

Q9Y2Z2
PEPLKKYTKCRELAE

MTO1

591

Q9Y2Z2
PCYKPKEKLPVEAKL

ADAMTSL1

491

Q8N6G6
APKDPKLYVCPIYKK

DNAH8

4441

Q96JB1
LAKLCYDPDFEKLKP

GSTM2

111

P28161
PVEKLTDYCKKLKEV

LRPPRC

386

P42704
LECKKKFPPVKEAAE

MON2

26

Q7Z3U7
YIPLQEEDTKKPKDK

HECTD4

3011

Q9Y4D8
PEEYELKSTKKGCKR

MSH6

991

P52701
VKKLEMKPKYPHCEE

CXCL14

51

O95715
IPEKKKNKDVYPSCS

FBXO38

691

Q6PIJ6
KKCESIVEPKPTLKY

P2RX7

386

Q99572
PKEVCKLEVIFAPKK

HYDIN

4481

Q4G0P3
VLPKKPKKVAFDCLE

BLM

866

P54132
KKYCPKRSSKDEEPR

FNBP1L

51

Q5T0N5
KCPPELEKKYQKEEF

FCGBP

1446

Q9Y6R7
SDKCPPELEKKYQKE

FCGBP

3846

Q9Y6R7
VTPSEKAYEKPPEKK

ILF2

351

Q12905
PVPVKKYTFKLKEVD

ANK3

3326

Q12955
EKVCKLEKVYIPPEA

FAM172BP

71

A6NC97
KKCLEKKVLYVDPEF

CAPN3

66

P20807
PCYEAVLPKEKLKVE

RYR2

821

Q92736
VAKKEKPKAVIPIYE

LRRC43

611

Q8N309
KKKKKTKPECPCSEE

PHF20

546

Q9BVI0
PEKKEKGYPKLLQDE

HPX

121

P02790
LEKEKDYPKSIPLKI

ARHGAP20

186

Q9P2F6
EEYKNAKPKEELLKP

RIC8B

476

Q9NVN3
KKTNPEIKEKPCHFE

JAML

316

Q86YT9
PYETAVAKCKEKLPV

RGMA

356

Q96B86
DKLCKEVPNYKLITP

RPS25

56

P62851
PISKKEKDKYLDVCP

SETD1A

1501

O15047
PEKEKLPAKAVYDFK

SORBS2

861

O94875
PEYLKVFKDDRCKIP

NCAPG2

656

Q86XI2
CVKYGTKIKEEPPSE

RLF

1591

Q13129
PKKPFVKLKDCIELF

USP15

781

Q9Y4E8
RITEKKPYKCKECGK

ZNF730

221

Q6ZMV8
YKDPKKLCEEDLEKL

ZHX2

731

Q9Y6X8
IKDIPKFEVYCKKIP

VPS13B

3271

Q7Z7G8
KVKPKNAEDCLYELP

C9orf78

136

Q9NZ63
NYKAVCLELKPEPTK

TEX35

16

Q5T0J7
CLELKPEPTKTFDYK

TEX35

21

Q5T0J7
DLSKPPMPCEEKKTY

ZNF71

116

Q9NQZ8
KPKYPQCKESKKDLI

MYT1L

866

Q9UL68