Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyCellularComponentperineuronal net

HAPLN4 HAPLN2

2.59e-0410512GO:0072534
GeneOntologyCellularComponentperisynaptic extracellular matrix

HAPLN4 HAPLN2

3.16e-0411512GO:0098966
GeneOntologyCellularComponentsynapse-associated extracellular matrix

HAPLN4 HAPLN2

4.47e-0413512GO:0099535
DomainCarb-bd-like_fold

CILP2 EPM2A

2.03e-048512IPR013784
DomainMIR

POMT2 RYR2

3.24e-0410512PS50919
DomainMIR

POMT2 RYR2

3.24e-0410512PF02815
DomainMIR

POMT2 RYR2

3.24e-0410512SM00472
DomainMIR_motif

POMT2 RYR2

3.24e-0410512IPR016093
DomainLINK

HAPLN4 HAPLN2

5.59e-0413512SM00445
DomainLink_dom

HAPLN4 HAPLN2

5.59e-0413512IPR000538
DomainXlink

HAPLN4 HAPLN2

5.59e-0413512PF00193
DomainLINK_1

HAPLN4 HAPLN2

5.59e-0413512PS01241
DomainLINK_2

HAPLN4 HAPLN2

5.59e-0413512PS50963
PathwayREACTOME_LIGAND_RECEPTOR_INTERACTIONS

HHIP DHH

1.25e-047352MM15224
PathwayREACTOME_LIGAND_RECEPTOR_INTERACTIONS

HHIP DHH

1.66e-048352M27496
Pubmed

Hapln4/Bral2 is a selective regulator for formation and transmission of GABAergic synapses between Purkinje and deep cerebellar nuclei neurons.

HAPLN4 HAPLN2

2.46e-06255230125937
Pubmed

Reduced expression of the hyaluronan and proteoglycan link proteins in malignant gliomas.

HAPLN4 HAPLN2

2.46e-06255219633295
Pubmed

Structural insights into hedgehog ligand sequestration by the human hedgehog-interacting protein HHIP.

HHIP DHH

7.36e-06355219561611
Pubmed

A hyaluronan binding link protein gene family whose members are physically linked adjacent to chondroitin sulfate proteoglycan core protein genes: the missing links.

HAPLN4 HAPLN2

1.47e-05455212663660
Pubmed

Pink1 regulates FKBP5 interaction with AKT/PHLPP and protects neurons from neurotoxin stress induced by MPP.

PHLPP1 PINK1

1.47e-05455230734931
Pubmed

Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein.

HHIP DHH

2.45e-05555210050855
Pubmed

Molecular cloning of Bral2, a novel brain-specific link protein, and immunohistochemical colocalization with brevican in perineuronal nets.

HAPLN4 HAPLN2

3.67e-05655214550776
Pubmed

Candidate gene analysis of the human natural killer-1 carbohydrate pathway and perineuronal nets in schizophrenia: B3GAT2 is associated with disease risk and cortical surface area.

HAPLN4 HAPLN2

1.10e-041055220950796
Pubmed

Hedgehog signaling regulates differentiation from double-negative to double-positive thymocyte.

HHIP DHH

1.60e-041255210981962
Pubmed

AGO61-dependent GlcNAc modification primes the formation of functional glycans on α-dystroglycan.

POMT2 LARGE2

1.60e-041255224256719
Pubmed

Expression patterns of Hedgehog signalling pathway members during mouse palate development.

HHIP DHH

1.89e-041355216168717
Pubmed

Opposing roles of hepatic stellate cell subpopulations in hepatocarcinogenesis.

DDR1 HHIP

1.89e-041355236198802
Pubmed

Pth1r in Neural Crest Cells Regulates Nasal Cartilage Differentiation.

HHIP DHH

2.54e-041555238234039
Pubmed

GATA4 and GATA6 regulate pancreatic endoderm identity through inhibition of hedgehog signaling.

HHIP DHH

2.90e-041655226932670
Pubmed

Overactivation of hedgehog signaling alters development of the ovarian vasculature in mice.

HHIP DHH

3.29e-041755222402963
Pubmed

RUNX1 maintains the identity of the fetal ovary through an interplay with FOXL2.

DHH RYR2

5.06e-042155231712577
Pubmed

Quantitative trait loci for body size components in mice.

FZD9 DDR1 SCAP

5.12e-049855316783635
Pubmed

Primary cilia function regulates the length of the embryonic trunk axis and urogenital field in mice.

HHIP DHH

5.56e-042255225224227
Pubmed

SRSF2 in Sertoli cells is essential for testicular development and spermatogenesis in mice.

DHH WTIP

5.56e-042255237039821
Pubmed

Eliminating SF-1 (NR5A1) sumoylation in vivo results in ectopic hedgehog signaling and disruption of endocrine development.

HHIP DHH

9.04e-042855221820362
Pubmed

Genomic analysis of mouse retinal development.

FZD9 NAT8L DDR1 RNF169 C1orf122 ZNF688 ZNF768

1.00e-03100655715226823
Pubmed

Hypertrophic Cardiomyopathy Overview

ALPK3 RYR2

1.33e-033455220301725
Pubmed

Sexually dimorphic gene expression in the developing mouse gonad.

HHIP DHH

1.41e-033555212617826
Pubmed

Fine-scale comparative mapping of the human 7q11.23 region and the orthologous region on mouse chromosome 5G: the low-copy repeats that flank the Williams-Beuren syndrome deletion arose at breakpoint sites of an evolutionary inversion(s).

FZD9 POM121

1.41e-033555211013070
Pubmed

Gonadal sex reversal in mutant Dax1 XY mice: a failure to upregulate Sox9 in pre-Sertoli cells.

HHIP DHH

1.49e-033655215944188
InteractionMAMDC4 interactions

POMT2 TAF6L POM121

1.44e-0519513int:MAMDC4
ToppCellControl-MAIT|World / Disease group and Cell class

GAS2L1 DDR1 CYP27A1 RYK

4.90e-051635540ca4b835936b4f82217cbe57210c1dd90986c1d0
ToppCelldroplet-Lung-nan-3m-Myeloid-plasmacytoid_dendritic_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TAF6L FZD9 DDR1 CYP27A1

6.18e-051735541b9b4e165121b08ef15a93fca6bea875cae69f19
ToppCelldroplet-Lung-nan-3m-Myeloid-Plasmacytoid_Dendritic|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TAF6L FZD9 DDR1 CYP27A1

6.18e-05173554c25f24d7b672c9686d31ebc8d263042282f520fd
ToppCellSubstantia_nigra-Macroglia|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

DDR1 HHIP SYDE2 CYP27A1

6.32e-051745547e7f7ca9a413ec255e54621800a279c771b9e6b7
ToppCell3'-Parenchyma_lung-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting-Basal_resting_L.0.0.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DPH1 EVPLL SYDE2 PLCH2

6.75e-0517755475cb2067a3f2d1b5a964890b02b604d1e79bd163
ToppCellEntopeduncular-Macroglia|Entopeduncular / BrainAtlas - Mouse McCarroll V32

DDR1 HHIP CYP27A1 PHLPP1

7.05e-05179554f61974710a60aa0618fdb30d864fb9bc7c05ef21
ToppCellcellseq-Mesenchymal-Chondrocytic-Mesenchymal_Airway/Vascular|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

LARGE2 FZD9 NAT8L CILP2

7.52e-05182554bb7de0c93d8f59f13c990e425139b9348ca8027e
ToppCellcellseq-Mesenchymal-Chondrocytic-Mesenchymal_Airway/Vascular-Chondrocyte|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

LARGE2 FZD9 NAT8L CILP2

7.52e-05182554507f095af4dff60f2c2b64d750477154084c3595
ToppCellcellseq-Mesenchymal-Chondrocytic|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

LARGE2 FZD9 NAT8L CILP2

7.52e-0518255488bd17c07bd8443a0ede4e9dc7bc9d1230b42211
ToppCell(7)_Epithelial-H_(AT1)|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

DDR1 EVPLL PLCH2 ITGA3

7.85e-051845541f76b37c265b519171b767a52d48f31f0cdc4a3c
ToppCellE12.5-Mesenchymal-mesenchymal_fibroblast-mesothelial_cell_of_visceral_pleura|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

DDR1 HHIP RNF112 ITGA3

8.18e-051865541587667e5084ac43505d027af925ba711e228150
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-24m-Neuronal-neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NAT8L PLCH2 HAPLN4 RYR2

8.35e-05187554e04a84989d624378141042768383b9c846901f2d
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-24m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NAT8L PLCH2 HAPLN4 RYR2

8.35e-0518755424cc03c748e15f7ef0e6509ca5a6ca583fb9c573
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-24m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NAT8L PLCH2 HAPLN4 RYR2

8.35e-051875542f153b203fe79f206319603cf94d3a03ab49a05d
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

WTIP DACT3 HAPLN2 RYR2

8.70e-05189554fac5c291a9a87418bb0878c3d624829bdbf1f428
ToppCellSomatosensory_Cortex_(S1)-Non-neuronal-Macroglial|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DDR1 CYP27A1 HAPLN2 PHLPP1

8.88e-0519055407f21386ea6eb23416a537d2250e3042efe93fb0
ToppCellPrimary_Motor_Cortex_(M1)-Non-neuronal-Macroglial|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DDR1 CYP27A1 HAPLN2 PHLPP1

8.88e-05190554ae97df1b06bcd46c05759b53c35dc8fea97f4ac1
ToppCellPrimary_Motor_Cortex_(M1)-Non-neuronal|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DDR1 CYP27A1 HAPLN2 PHLPP1

9.06e-051915542b056cbe2e82e056e1f798974999378460eb1d16
ToppCellfacs-Aorta-Heart-3m-Mesenchymal-leukocyte|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FZD9 CILP2 PLCH2 ITGA3

9.06e-05191554116fba9badea093e11f370996247cca0e4c02e8f
ToppCellPND07-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LARGE2 DDR1 MISP3 ITGA3

9.06e-05191554ce76b156b153a2c7c9f2fb8e563b69c81073fbe5
ToppCellPND07-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1-AT1_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LARGE2 DDR1 MISP3 ITGA3

9.06e-05191554c006f5a6e3a32b79ac99a78304bdd5116fc0d5e0
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NAT8L TMEM121B RNF112 RYR2

9.43e-05193554be28070c049e7cb68bcd54f582226eb2f5e4bc1c
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NAT8L TMEM121B RNF112 RYR2

9.43e-051935540c652ebe22ce5d2927599dd97ef1920547858395
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Neuronal-neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NAT8L TMEM121B RNF112 RYR2

9.43e-051935548689a70a33a7c3823dc647d41ac0160e7c3ae396
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte-A|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

HHIP MAP7D1 CYP27A1 HAPLN2

9.82e-051955541e28617ca55e5f318a228357737b968dfac8cca0
ToppCellTracheal-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_systemic_arterial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

WTIP DACT3 ALPK3 RYR2

1.04e-041985547dd874b09c81cc512ccc1e9b65f290a5f94d736e
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-3m-Macroglial-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DDR1 HHIP HAPLN2 PHLPP1

1.08e-042005540e85c90719d9ec51a566e230c9dd2909d8df1f52
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW16-Neuronal-Intermediate|GW16 / Sample Type, Dataset, Time_group, and Cell type.

WTIP PLCH2 CBLN2 ITGA3

1.08e-04200554a3fcd901cb281920f1bafdfd676399a6dc37355e
DiseasePR interval

OTUD7A ALPK3 EME2 RYR2 GJD4

1.35e-03495495EFO_0004462
Diseaseheart disease (implicated_via_orthology)

KCNK16 RYR2

1.83e-0338492DOID:114 (implicated_via_orthology)
Diseasehepatocyte growth factor measurement

DPH1 OTUD7A

2.44e-0344492EFO_0006903
DiseaseHypertrophic Cardiomyopathy

ALPK3 RYR2

4.07e-0357492C0007194

Protein segments in the cluster

PeptideGeneStartEntry
GALGAARCRPPEAGR

EPM2A

81

B3EWF7
RLPGGVECRFRRGPA

DDR1

296

Q08345
RQPRAGAAAAGRGPG

ALPK3

166

Q96L96
RQLGRRRPEPAGGGN

C1orf122

66

Q6ZSJ8
EQGGRDGPGRGRAPR

DPH1

16

Q9BZG8
DGPGRGRAPRGRVAN

DPH1

21

Q9BZG8
LGCERREPGGRAGAP

LARGE2

31

Q8N3Y3
DPQRGGPGPGVRRRC

PAXX

166

Q9BUH6
SRVLGRRRPGQAPGG

OR10AC1

306

Q8NH08
ARAPCGGRGRPGIRS

HAPLN2

211

Q9GZV7
QGCGAKAAPGRRPRR

KCNK16

271

Q96T55
QRRCPRPFGERGGLQ

GJD4

121

Q96KN9
LGRPGPAAGCVRGER

PINK1

31

Q9BXM7
QRRRRQLDPGGGQGP

ITGA3

871

P26006
RPRNPAGRTGLVGRG

NUDT9

146

Q9BW91
RPRRAAAEPGGAGCR

EVPLL

146

A8MZ36
GECGRGGPGPVQRRC

OTUD7A

876

Q8TE49
RDGRGRGCGGPARAV

POM121

21

Q96HA1
GRFDPERGRGAAPCQ

FZD9

26

O00144
RRRGAGQPRTSPGGA

DACT3

261

Q96B18
QSCGPGRGPVGRRRY

DHH

21

O43323
RGRPRGAPGGRGAQL

GAS2L1

411

Q99501
TGAPGAGPGVRRRQR

CYP27A1

41

Q02318
PGRRGALREPGGCGS

CBLN2

16

Q8IUK8
PCCGDGGARGRRRLP

FRMD6-AS1

256

P0C7T7
GRDQGRGCDPGRGPT

MAP7D1

321

Q3KQU3
RARCGGRRPGVRSLG

HAPLN4

336

Q86UW8
PGRAGVSCQGRGRGR

EME2

6

A4GXA9
LGGGPGRRRRGELPC

SCAP

741

Q12770
RLGRPGRSCLPGARG

RYK

6

P34925
RRPECFGPALRGEGG

RYR2

2326

Q92736
RACPRDGERGGGGRP

SYDE2

41

Q5VT97
AAEPNRGGPGGRGCR

TAF6L

376

Q9Y6J9
RGGPGGRGCRRLDDL

TAF6L

381

Q9Y6J9
PRRGRCGPQAARAAG

POMT2

16

Q9UKY4
RGPRGCRDRDGPAGG

TMEM80

56

Q96HE8
GCPDRPGRRGRRRGC

TMEM121B

176

Q9BXQ6
VLEPGGPGGCAARRR

NAGPA

106

Q9UK23
GDCGRPRARPGGNRV

ADSS2

16

P30520
CRPRRDGGAAAAGPR

RNF169

141

Q8NCN4
GSGARRRRCLNGNPP

HHIP

31

Q96QV1
GPCSGSCGPGRRLRR

CILP2

156

Q8IUL8
RGPGEARGERPGPAC

ZNF513

106

Q8N8E2
EPGGRPRSAVQGGCR

MISP3

126

Q96FF7
SRSGCRVPRGGGRQG

RBMXL3

1041

Q8N7X1
GGRPRGGEASLQGCR

RNF112

201

Q9ULX5
FQFRGRCGRGRGQPP

RPS10P5

161

Q9NQ39
PRDSRPRPCNGEGAG

PLCH2

1051

O75038
RARGGQGPRPNICGI

ZNF768

251

Q9H5H4
PRCSRRPGGSRLRGG

PYCARD-AS1

91

I3L0S3
GVGPRTGRGNRLCRP

nan

41

Q6ZRN7
TGRGNRLCRPPGRSA

nan

46

Q6ZRN7
CSGGRRGRRPGIRAV

ZNF688

236

P0C7X2
GRRRRRGAPQPIAGG

PHLPP1

91

O60346
RELEPGCGSPGRGRR

WTIP

21

A6NIX2
ERGPFRGGQDCRGPP

WDR33

986

Q9C0J8
RGGQDCRGPPDRRGP

WDR33

991

Q9C0J8
PRCRGRGARPGGRPA

ZGPAT

396

Q8N5A5
GPGKAPAGGGCRRQR

ZFTA

211

C9JLR9
PAGGGCRRQRRGGPV

ZFTA

216

C9JLR9
GPPGGRGVCIREFRA

NAT8L

71

Q8N9F0