Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiongamma-catenin binding

DSG1 APC

3.99e-0412502GO:0045295
GeneOntologyMolecularFunctioncomplement component C3b binding

CFH CFHR4

3.99e-0412502GO:0001851
GeneOntologyBiologicalProcessadaptive immune response

EPHB2 CFH LIG4 IGLV2-18 IGLV2-14 IGLV2-11 BTN3A3 IGLV2-8 SUSD4 IL18 TRA TRAV38-2DV8 IGLV6-57 BTN3A2 BTN3A1 SVEP1 CFHR4

1.10e-118385217GO:0002250
GeneOntologyBiologicalProcessleukocyte mediated immunity

CFH LIG4 IGLV2-14 BTN3A3 SUSD4 IL18 ABR TRA BTN3A2 MILR1 SVEP1 CFHR4

1.50e-085765212GO:0002443
GeneOntologyBiologicalProcessadaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

EPHB2 CFH LIG4 IGLV2-14 BTN3A3 SUSD4 IL18 TRA BTN3A2 SVEP1 CFHR4

1.67e-084625211GO:0002460
GeneOntologyBiologicalProcessimmune effector process

EPHB2 CFH LIG4 IGLV2-14 BTN3A3 SUSD4 IL18 ABR TRA MUC19 BTN3A2 MILR1 SVEP1 CFHR4

1.72e-088595214GO:0002252
GeneOntologyBiologicalProcessimmunoglobulin production

EPHB2 LIG4 IGLV2-18 IGLV2-14 IGLV2-11 IGLV2-8 TRAV38-2DV8 IGLV6-57

1.49e-07241528GO:0002377
GeneOntologyBiologicalProcesslymphocyte mediated immunity

CFH LIG4 IGLV2-14 BTN3A3 SUSD4 IL18 TRA BTN3A2 SVEP1 CFHR4

1.51e-074495210GO:0002449
GeneOntologyBiologicalProcessregulation of complement activation, alternative pathway

CFH SUSD4 CFHR4

5.25e-077523GO:0030451
GeneOntologyBiologicalProcessregulation of complement activation

CFH SUSD4 SVEP1 CFHR4

6.04e-0727524GO:0030449
GeneOntologyBiologicalProcessproduction of molecular mediator of immune response

EPHB2 LIG4 IGLV2-18 IGLV2-14 IGLV2-11 IGLV2-8 IL18 TRAV38-2DV8 IGLV6-57

6.64e-07403529GO:0002440
GeneOntologyBiologicalProcessregulation of immune response

EPHB2 CFH BTN3A3 SUSD4 IL18 ABR TLR5 IGSF1 BTN3A2 BTN3A1 SVEP1 CFHR4

1.23e-0510855212GO:0050776
GeneOntologyBiologicalProcesscomplement activation, alternative pathway

CFH SUSD4 CFHR4

1.42e-0519523GO:0006957
GeneOntologyBiologicalProcessregulation of humoral immune response

CFH SUSD4 SVEP1 CFHR4

1.58e-0560524GO:0002920
GeneOntologyBiologicalProcessimmunoglobulin mediated immune response

CFH LIG4 IGLV2-14 SUSD4 SVEP1 CFHR4

2.70e-05235526GO:0016064
GeneOntologyBiologicalProcesscomplement activation

CFH SUSD4 SVEP1 CFHR4

2.91e-0570524GO:0006956
GeneOntologyBiologicalProcessB cell mediated immunity

CFH LIG4 IGLV2-14 SUSD4 SVEP1 CFHR4

3.33e-05244526GO:0019724
GeneOntologyBiologicalProcessregulation of response to external stimulus

EPHB2 CFH LGMN SUSD4 IL18 ABR NRXN1 SIGIRR TLR5 MUC19 EPHA4 CFHR4

8.22e-0513165212GO:0032101
GeneOntologyBiologicalProcessactivation of membrane attack complex

CFH CFHR4

9.29e-056522GO:0001905
GeneOntologyBiologicalProcessneutrophil homeostasis

CFH IL18 CFHR4

9.34e-0535523GO:0001780
GeneOntologyBiologicalProcessactivation of immune response

CFH BTN3A3 SUSD4 TLR5 BTN3A2 BTN3A1 SVEP1 CFHR4

1.54e-04623528GO:0002253
GeneOntologyBiologicalProcessnegative regulation of complement activation, classical pathway

SUSD4 SVEP1

1.73e-048522GO:0045959
GeneOntologyBiologicalProcesspositive regulation of immune system process

EPHB2 CFH LGMN BTN3A3 SUSD4 IL18 TLR5 BTN3A2 BTN3A1 SVEP1 CFHR4

2.22e-0412425211GO:0002684
GeneOntologyBiologicalProcessmonocyte aggregation

CFH CFHR4

2.22e-049522GO:0070487
GeneOntologyBiologicalProcessimmune complex clearance

CFH CFHR4

2.22e-049522GO:0002434
GeneOntologyBiologicalProcesspositive regulation of immune response

CFH BTN3A3 SUSD4 IL18 TLR5 BTN3A2 BTN3A1 SVEP1 CFHR4

2.35e-04845529GO:0050778
GeneOntologyBiologicalProcessregulation of immune effector process

EPHB2 CFH SUSD4 IL18 ABR SVEP1 CFHR4

2.37e-04497527GO:0002697
GeneOntologyBiologicalProcesscellular response to amyloid-beta

EPHB2 LGMN EPHA4

2.57e-0449523GO:1904646
GeneOntologyBiologicalProcessregulation of complement activation, classical pathway

SUSD4 SVEP1

2.77e-0410522GO:0030450
GeneOntologyBiologicalProcessretinal pigment epithelium development

CFH CFHR4

2.77e-0410522GO:0003406
GeneOntologyBiologicalProcesspostsynaptic membrane assembly

EPHB2 NRXN1

3.38e-0411522GO:0097104
GeneOntologyBiologicalProcesscell-cell junction organization

EPHB2 DSG1 APC SVEP1 EPHA4

3.81e-04246525GO:0045216
GeneOntologyBiologicalProcessnegative regulation of humoral immune response mediated by circulating immunoglobulin

SUSD4 SVEP1

4.05e-0412522GO:0002924
GeneOntologyBiologicalProcessresponse to bacterium

EPHB2 CFH SSC5D IL18 ABR TRA SIGIRR MUC19 CFHR4

4.26e-04916529GO:0009617
GeneOntologyBiologicalProcesscell activation

EPHB2 CFH LIG4 IL18 ABR MUC19 APC BTN3A1 MILR1 SVEP1 CFHR4

4.71e-0413565211GO:0001775
GeneOntologyBiologicalProcessregulation of complement-dependent cytotoxicity

CFH CFHR4

4.78e-0413522GO:1903659
GeneOntologyBiologicalProcessresponse to amyloid-beta

EPHB2 LGMN EPHA4

4.91e-0461523GO:1904645
GeneOntologyBiologicalProcessnegative regulation of complement activation

SUSD4 SVEP1

5.56e-0414522GO:0045916
GeneOntologyBiologicalProcessregulation of long-term synaptic potentiation

EPHB2 LGMN EPHA4

6.46e-0467523GO:1900271
GeneOntologyBiologicalProcessnegative regulation of B cell mediated immunity

SUSD4 SVEP1

7.31e-0416522GO:0002713
GeneOntologyBiologicalProcessnegative regulation of immunoglobulin mediated immune response

SUSD4 SVEP1

7.31e-0416522GO:0002890
GeneOntologyBiologicalProcesscomplement-dependent cytotoxicity

CFH CFHR4

7.31e-0416522GO:0097278
GeneOntologyBiologicalProcessT cell mediated immunity

BTN3A3 IL18 TRA BTN3A2

7.57e-04163524GO:0002456
GeneOntologyBiologicalProcessmechanosensory behavior

NRXN1 ETV1

8.28e-0417522GO:0007638
GeneOntologyBiologicalProcessretinal rod cell development

CFH CFHR4

8.28e-0417522GO:0046548
GeneOntologyBiologicalProcessregulation of NMDA receptor activity

EPHB2 NRXN1

9.29e-0418522GO:2000310
GeneOntologyBiologicalProcessleukocyte aggregation

CFH CFHR4

1.04e-0319522GO:0070486
GeneOntologyBiologicalProcessnegative regulation of humoral immune response

SUSD4 SVEP1

1.04e-0319522GO:0002921
GeneOntologyCellularComponentimmunoglobulin complex

IGLV2-18 IGLV2-14 IGLV2-11 IGLV2-8 IGLV6-57

5.71e-05166525GO:0019814
GeneOntologyCellularComponentsymbiont cell surface

CFH CFHR4

1.68e-048522GO:0106139
GeneOntologyCellularComponentaxonal growth cone

NRXN1 APC EPHA4

1.91e-0445523GO:0044295
GeneOntologyCellularComponentother organism part

CFH CFHR4

2.16e-049522GO:0044217
GeneOntologyCellularComponentbeta-catenin destruction complex

APC AXIN2

4.65e-0413522GO:0030877
GeneOntologyCellularComponentserine-type endopeptidase complex

CFH CFHR4

1.12e-0320522GO:1905370
GeneOntologyCellularComponentserine-type peptidase complex

CFH CFHR4

1.36e-0322522GO:1905286
GeneOntologyCellularComponentcell surface

EPHB2 CFH BTN3A3 NRXN1 BTN3A2 BTN3A1 MILR1 EPHA4 CFHR4

1.53e-031111529GO:0009986
GeneOntologyCellularComponentexternal side of plasma membrane

CFH BTN3A3 BTN3A2 BTN3A1 MILR1 CFHR4

1.76e-03519526GO:0009897
GeneOntologyCellularComponentGolgi lumen

PCSK5 MUC19 MUC2

2.53e-03109523GO:0005796
HumanPhenoFundic gland polyposis

APC AXIN2

6.01e-062132HP:0033769
MousePhenoabnormal complement protein level

CFH SUSD4 CFHR4

1.30e-069363MP:0011566
MousePhenoabnormal creatine level

CFH SLC4A11 CFHR4

1.30e-069363MP:0010060
MousePhenoartery occlusion

CFH CFHR4

6.45e-062362MP:0006134
MousePhenoabnormal hepatic portal vein thrombosis

CFH CFHR4

6.45e-062362MP:0031159
MousePhenowhite pupil

CFH CFHR4

6.45e-062362MP:0006242
MousePhenodecreased serum complement activity

CFH CFHR4

6.45e-062362MP:0012553
MousePhenodecreased complement C5 level

CFH CFHR4

6.45e-062362MP:0012609
MousePhenoabnormal complement C5 level

CFH CFHR4

6.45e-062362MP:0012608
MousePhenoabnormal kidney venous thrombosis

CFH CFHR4

1.93e-053362MP:0031161
MousePhenoincreased susceptilbility to retina ischemic injury

CFH CFHR4

1.93e-053362MP:0012049
MousePhenoincreased susceptibility to type III hypersensitivity reaction

CFH CFHR4

3.86e-054362MP:0005615
MousePhenomesangial cell interposition

CFH CFHR4

3.86e-054362MP:0011512
MousePhenoabnormal brain thrombosis

CFH CFHR4

3.86e-054362MP:0031168
MousePhenoabnormal response to retina ischemic injury

CFH CFHR4

3.86e-054362MP:0012048
MousePhenodecreased circulating complement protein level

CFH CFHR4

3.86e-054362MP:0020216
MousePhenoincreased creatine level

CFH CFHR4

3.86e-054362MP:0010061
MousePhenoabnormal complement pathway

CFH SUSD4 CFHR4

3.92e-0526363MP:0002471
MousePhenoabnormal venous thrombosis

CFH CFHR4

6.42e-055362MP:0031158
MousePhenoabnormal lung thrombosis

CFH CFHR4

6.42e-055362MP:0031167
MousePhenoabnormal circulating complement protein level

CFH CFHR4

9.61e-056362MP:0010215
MousePhenoabnormal intestine physiology

LIG4 IL18 SIGIRR TLR5 APC OCA2

9.96e-05297366MP:0010155
MousePhenointestinal inflammation

LIG4 IL18 SIGIRR TLR5 OCA2

1.33e-04195365MP:0001858
MousePhenoabnormal glomerular capillary thrombosis

CFH CFHR4

1.34e-047362MP:0011508
MousePhenobrain ischemia

CFH CFHR4

1.79e-048362MP:0006080
MousePhenoincreased large intestine adenocarcinoma incidence

LIG4 APC

1.79e-048362MP:0009310
MousePhenoabnormal adaptive immunity

MYCL CFH LGMN LIG4 IGLV2-14 SUSD4 IL18 SIGIRR TLR5 OCA2 MILR1 CFHR4

2.24e-0414903612MP:0002420
MousePhenoabnormal type III hypersensitivity reaction

CFH CFHR4

2.86e-0410362MP:0002533
MousePhenoabnormal kidney thrombosis

CFH CFHR4

2.86e-0410362MP:0011507
MousePhenoabnormal anterior commissure pars posterior morphology

EPHB2 EPHA4

2.86e-0410362MP:0010860
MousePhenoincreased susceptibility to induced colitis

IL18 SIGIRR TLR5 OCA2

3.15e-04128364MP:0008537
MousePhenoabnormal visual acuity

CFH CFHR4

4.94e-0413362MP:0011832
MousePhenodecreased visual acuity

CFH CFHR4

4.94e-0413362MP:0006149
MousePhenoincreased total fat pad weight

IL18 OCA2

4.94e-0413362MP:0008908
MousePhenoalbuminuria

CFH LGMN CFHR4

5.60e-0463363MP:0002871
MousePhenoabnormal Bruch membrane morphology

CFH CFHR4

5.75e-0414362MP:0005239
MousePhenoretina detachment

CFH CFHR4

6.63e-0415362MP:0003099
MousePhenocolitis

IL18 SIGIRR TLR5 OCA2

7.15e-04159364MP:0002816
MousePhenoabnormal digestive system physiology

EPHB2 LIG4 IL18 SIGIRR TLR5 APC OCA2

7.22e-04599367MP:0001663
MousePhenoabnormal parental behavior

NRXN1 APC OCA2 EPHA4

7.32e-04160364MP:0002068
MousePhenoabnormal susceptibility to induced colitis

IL18 SIGIRR TLR5 OCA2

7.49e-04161364MP:0013296
MousePhenoincreased acute inflammation

CFH SIGIRR MILR1 CFHR4

8.03e-04164364MP:0005088
MousePhenoamyloid beta deposits

CFH CFHR4

8.56e-0417362MP:0003329
MousePhenocardia bifida

APC AXIN2

8.56e-0417362MP:0004187
MousePhenolarge intestinal inflammation

IL18 SIGIRR TLR5 OCA2

1.00e-03174364MP:0003304
MousePhenodecreased interleukin-12b secretion

LGMN TLR5

1.07e-0319362MP:0008670
MousePhenohematuria

CFH CFHR4

1.07e-0319362MP:0005161
MousePhenoreticulocytosis

CFH LGMN CFHR4

1.12e-0380363MP:0002640
MousePhenoabnormal glomerular capillary endothelium morphology

CFH CFHR4

1.31e-0321362MP:0011453
MousePhenoabnormal innate immunity

CFH LGMN SUSD4 IL18 TLR5 OCA2 CFHR4

1.36e-03667367MP:0002419
MousePhenoincreased intestinal adenocarcinoma incidence

LIG4 APC

1.44e-0322362MP:0002957
MousePhenoabnormal gut flora balance

IL18 TLR5

1.44e-0322362MP:0010377
MousePhenoabnormal retina rod bipolar cell morphology

CFH CFHR4

1.58e-0323362MP:0006074
MousePhenoabnormal reticulocyte cell number

CFH LGMN CFHR4

1.63e-0391363MP:0011913
DomainEphrin_rec_like

EPHB2 PCSK5 SVEP1 EPHA4

3.58e-0725454SM01411
DomainTyr-kin_ephrin_A/B_rcpt-like

EPHB2 PCSK5 SVEP1 EPHA4

3.58e-0725454IPR011641
DomainIg-like_fold

EPHB2 BTN3A3 TRA SIGIRR IGSF1 BTN3A2 BTN3A1 MILR1 EPHA4 TMEM81

5.37e-067064510IPR013783
DomainSushi

CFH SUSD4 SVEP1 CFHR4

7.31e-0652454PF00084
DomainCCP

CFH SUSD4 SVEP1 CFHR4

8.51e-0654454SM00032
DomainSUSHI

CFH SUSD4 SVEP1 CFHR4

9.85e-0656454PS50923
DomainSushi_SCR_CCP_dom

CFH SUSD4 SVEP1 CFHR4

1.06e-0557454IPR000436
Domain-

EPHB2 BTN3A3 SIGIRR IGSF1 BTN3A2 BTN3A1 MILR1 EPHA4 TMEM81

2.39e-056634592.60.40.10
DomainIG_LIKE

BTN3A3 SIGIRR IGSF1 BTN3A2 BTN3A1 MILR1 TMEM81

1.59e-04491457PS50835
DomainIg-like_dom

BTN3A3 SIGIRR IGSF1 BTN3A2 BTN3A1 MILR1 TMEM81

1.84e-04503457IPR007110
DomainEphrin_rec_like

EPHB2 SVEP1

3.08e-0411452PF07699
DomainTIL

MUC19 MUC2

3.69e-0412452PF01826
DomainC8

MUC19 MUC2

3.69e-0412452PF08742
DomainUnchr_dom_Cys-rich

MUC19 MUC2

4.35e-0413452IPR014853
DomainC8

MUC19 MUC2

4.35e-0413452SM00832
DomainIG

BTN3A3 IGSF1 BTN3A2 BTN3A1 MILR1 TMEM81

4.90e-04421456SM00409
DomainIg_sub

BTN3A3 IGSF1 BTN3A2 BTN3A1 MILR1 TMEM81

4.90e-04421456IPR003599
DomainRECEPTOR_TYR_KIN_V_2

EPHB2 EPHA4

5.07e-0414452PS00791
DomainRECEPTOR_TYR_KIN_V_1

EPHB2 EPHA4

5.07e-0414452PS00790
DomainEph_TM

EPHB2 EPHA4

5.07e-0414452IPR027936
DomainTyr_kinase_rcpt_V_CS

EPHB2 EPHA4

5.07e-0414452IPR001426
DomainEPH_lbd

EPHB2 EPHA4

5.07e-0414452SM00615
DomainEphrin_lbd

EPHB2 EPHA4

5.07e-0414452PF01404
DomainTIL_dom

MUC19 MUC2

5.07e-0414452IPR002919
DomainEphA2_TM

EPHB2 EPHA4

5.07e-0414452PF14575
DomainTyr_kinase_ephrin_rcpt

EPHB2 EPHA4

5.07e-0414452IPR016257
DomainEphrin_rcpt_lig-bd_dom

EPHB2 EPHA4

5.07e-0414452IPR001090
DomainEPH_LBD

EPHB2 EPHA4

5.07e-0414452PS51550
DomainVWD

MUC19 MUC2

6.67e-0416452SM00216
DomainVWF_type-D

MUC19 MUC2

6.67e-0416452IPR001846
DomainVWFD

MUC19 MUC2

6.67e-0416452PS51233
DomainVWD

MUC19 MUC2

6.67e-0416452PF00094
Domain-

EPHB2 PCSK5 EPHA4

7.23e-04734532.60.120.260
DomainIGv

BTN3A3 BTN3A2 BTN3A1

7.82e-0475453SM00406
DomainCTCK_1

MUC19 MUC2

8.47e-0418452PS01185
DomainVWC_out

MUC19 MUC2

9.46e-0419452SM00215
DomainTIR

SIGIRR TLR5

1.16e-0321452SM00255
DomainTIR

SIGIRR TLR5

1.27e-0322452PF01582
DomainCT

MUC19 MUC2

1.27e-0322452SM00041
Domain-

SIGIRR TLR5

1.39e-03234523.40.50.10140
DomainGalactose-bd-like

EPHB2 PCSK5 EPHA4

1.50e-0394453IPR008979
DomainTIR

SIGIRR TLR5

1.51e-0324452PS50104
DomainCys_knot_C

MUC19 MUC2

1.64e-0325452IPR006207
DomainCTCK_2

MUC19 MUC2

1.64e-0325452PS01225
DomainTIR_dom

SIGIRR TLR5

1.64e-0325452IPR000157
DomainPROTEIN_KINASE_TYR

EPHB2 PEAK1 EPHA4

1.65e-0397453PS00109
DomainTyr_kinase_AS

EPHB2 PEAK1 EPHA4

1.65e-0397453IPR008266
DomainConA-like_dom

BTN3A3 NRXN1 BTN3A1 SVEP1

1.88e-03219454IPR013320
DomainEGF-type_Asp/Asn_hydroxyl_site

NRXN1 TLL2 SVEP1

2.12e-03106453IPR000152
DomainEGF

PCSK5 NRXN1 TLL2 SVEP1

2.43e-03235454SM00181
DomainEGF-like_dom

PCSK5 NRXN1 TLL2 SVEP1

2.99e-03249454IPR000742
DomainEGF

NRXN1 TLL2 SVEP1

3.46e-03126453PF00008
DomainEGF_2

EPHB2 NRXN1 TLL2 SVEP1

3.74e-03265454PS01186
DomainVWC

MUC19 MUC2

3.78e-0338452SM00214
DomainVWFC_2

MUC19 MUC2

3.78e-0338452PS50184
DomainPRY

BTN3A3 BTN3A1

4.60e-0342452PF13765
DomainVWF_dom

MUC19 MUC2

4.60e-0342452IPR001007
DomainPRY

BTN3A3 BTN3A1

5.97e-0348452SM00589
DomainPRY

BTN3A3 BTN3A1

5.97e-0348452IPR006574
DomainGrowth_fac_rcpt_

EPHB2 PCSK5 SVEP1

6.27e-03156453IPR009030
PathwayREACTOME_COMPLEMENT_CASCADE

CFH IGLV2-14 IGLV2-11 IGLV2-8 IGLV6-57 CFHR4

6.77e-07115396M19752
PathwayREACTOME_BUTYROPHILIN_BTN_FAMILY_INTERACTIONS

BTN3A3 BTN3A2 BTN3A1

4.23e-0612393M27738
PathwayREACTOME_BINDING_AND_UPTAKE_OF_LIGANDS_BY_SCAVENGER_RECEPTORS

SSC5D IGLV2-14 IGLV2-11 IGLV2-8 IGLV6-57

6.99e-0698395M27152
PathwayREACTOME_CD22_MEDIATED_BCR_REGULATION

IGLV2-14 IGLV2-11 IGLV2-8 IGLV6-57

2.33e-0561394M27581
PathwayREACTOME_FCGR_ACTIVATION

IGLV2-14 IGLV2-11 IGLV2-8 IGLV6-57

3.80e-0569394M27108
PathwayREACTOME_SCAVENGING_OF_HEME_FROM_PLASMA

IGLV2-14 IGLV2-11 IGLV2-8 IGLV6-57

3.80e-0569394M27150
PathwayREACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS

IGLV2-14 IGLV2-11 IGLV2-8 IGLV6-57

4.25e-0571394M1078
PathwayREACTOME_ROLE_OF_LAT2_NTAL_LAB_ON_CALCIUM_MOBILIZATION

IGLV2-14 IGLV2-11 IGLV2-8 IGLV6-57

4.25e-0571394M27203
PathwayREACTOME_INITIAL_TRIGGERING_OF_COMPLEMENT

IGLV2-14 IGLV2-11 IGLV2-8 IGLV6-57

6.80e-0580394M6121
PathwayREACTOME_ROLE_OF_PHOSPHOLIPIDS_IN_PHAGOCYTOSIS

IGLV2-14 IGLV2-11 IGLV2-8 IGLV6-57

7.49e-0582394M27110
PathwayREACTOME_FCERI_MEDIATED_CA_2_MOBILIZATION

IGLV2-14 IGLV2-11 IGLV2-8 IGLV6-57

9.02e-0586394M27206
PathwayREACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_BCR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS

IGLV2-14 IGLV2-11 IGLV2-8 IGLV6-57

9.02e-0586394M601
PathwayREACTOME_FCERI_MEDIATED_MAPK_ACTIVATION

IGLV2-14 IGLV2-11 IGLV2-8 IGLV6-57

9.44e-0587394M27205
PathwayKEGG_MEDICUS_REFERENCE_REGULATION_OF_COMPLEMENT_CASCADE_CFHR

CFH CFHR4

1.11e-046392M47880
PathwayREACTOME_FCGR3A_MEDIATED_IL10_SYNTHESIS

IGLV2-14 IGLV2-11 IGLV2-8 IGLV6-57

1.33e-0495394M29842
PathwayREACTOME_PARASITE_INFECTION

IGLV2-14 IGLV2-11 IGLV2-8 IGLV6-57

2.87e-04116394M29843
PathwayREACTOME_LEISHMANIA_INFECTION

IGLV2-14 IGLV2-11 IGLV2-8 IL18 IGLV6-57

3.24e-04219395M29836
PathwayREACTOME_ADAPTIVE_IMMUNE_SYSTEM

LGMN IGLV2-14 IGLV2-11 BTN3A3 IGLV2-8 KLHL13 IGLV6-57 BTN3A2 BTN3A1

3.42e-04828399M1058
PathwayKEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_APC_TO_WNT_SIGNALING_PATHWAY

APC AXIN2

4.84e-0412392M47410
PathwayREACTOME_ANTI_INFLAMMATORY_RESPONSE_FAVOURING_LEISHMANIA_PARASITE_INFECTION

IGLV2-14 IGLV2-11 IGLV2-8 IGLV6-57

4.96e-04134394M29840
PathwayREACTOME_FCERI_MEDIATED_NF_KB_ACTIVATION

IGLV2-14 IGLV2-11 IGLV2-8 IGLV6-57

5.25e-04136394M27207
PathwayREACTOME_FCGAMMA_RECEPTOR_FCGR_DEPENDENT_PHAGOCYTOSIS

IGLV2-14 IGLV2-11 IGLV2-8 IGLV6-57

6.34e-04143394M27107
PathwayREACTOME_INNATE_IMMUNE_SYSTEM

CFH LGMN IGLV2-14 IGLV2-11 IGLV2-8 DSG1 SIGIRR TLR5 IGLV6-57 CFHR4

7.67e-0411283910M1036
PathwayREACTOME_POTENTIAL_THERAPEUTICS_FOR_SARS

IGLV2-14 IGLV2-11 IGLV2-8 IGLV6-57

8.37e-04154394M39007
PathwayREACTOME_SIGNALING_BY_THE_B_CELL_RECEPTOR_BCR

IGLV2-14 IGLV2-11 IGLV2-8 IGLV6-57

1.11e-03166394M608
PathwayPID_BETA_CATENIN_DEG_PATHWAY

APC AXIN2

1.11e-0318392M31
PathwayREACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS

MUC19 MUC2

1.52e-0321392MM15706
PathwayREACTOME_COMPLEMENT_CASCADE

CFH IGLV2-14 CFHR4

1.60e-0384393MM14653
PathwayREACTOME_FC_EPSILON_RECEPTOR_FCERI_SIGNALING

IGLV2-14 IGLV2-11 IGLV2-8 IGLV6-57

1.68e-03186394M27175
PathwayREACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL

IGLV2-14 IGLV2-11 IGLV2-8 IGLV6-57

1.82e-03190394M8240
PathwayREACTOME_CELL_SURFACE_INTERACTIONS_AT_THE_VASCULAR_WALL

IGLV2-14 IGLV2-11 IGLV2-8 IGLV6-57

1.96e-03194394M16312
PathwayWP_WNTBETACATENIN_SIGNALING_IN_LEUKEMIA

APC AXIN2

2.32e-0326392M39407
Pubmed

Key implication of CD277/butyrophilin-3 (BTN3A) in cellular stress sensing by a major human γδ T-cell subset.

BTN3A3 BTN3A2 BTN3A1

3.34e-09353322767497
Pubmed

Sequence and evolution of the human germline V lambda repertoire.

IGLV2-18 IGLV2-14 IGLV2-11 IGLV2-8 IGLV6-57

1.23e-08495358951372
Pubmed

Primate-specific BTN3A2 protects against SARS-CoV-2 infection by interacting with and reducing ACE2.

BTN3A3 BTN3A2 BTN3A1

1.34e-08453339142074
Pubmed

Heteromeric interactions regulate butyrophilin (BTN) and BTN-like molecules governing γδ T cell biology.

BTN3A3 BTN3A2 BTN3A1

3.33e-08553329339503
Pubmed

The cluster of BTN genes in the extended major histocompatibility complex.

BTN3A3 BTN3A2 BTN3A1

1.16e-07753311170752
Pubmed

IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine.

IL18 TLR5 APC

5.47e-071153323075849
Pubmed

Activation of C1r by proteolytic cleavage.

IGLV2-18 IGLV2-14 IGLV2-11 IGLV6-57

5.67e-07435341249422
Pubmed

One-megabase sequence analysis of the human immunoglobulin lambda gene locus.

IGLV2-18 IGLV2-14 IGLV2-11 IGLV2-8 IGLV6-57

7.02e-071095359074928
Pubmed

Physicochemical and functional characterization of the C1r subunit of the first complement component.

IGLV2-18 IGLV2-14 IGLV2-11 IGLV6-57

8.16e-0747534814163
Pubmed

Recognition of immunoglobulins by Fcgamma receptors.

IGLV2-18 IGLV2-14 IGLV2-11 IGLV6-57

8.90e-074853411955599
Pubmed

New murine polymorphisms detected by random amplified polymorphic DNA (RAPD) PCR and mapped by use of recombinant inbred strains.

CFH OCA2 CFHR4

1.20e-06145337894156
Pubmed

Complement Factor H Modulates Splenic B Cell Development and Limits Autoantibody Production.

CFH CFHR4

2.28e-06253231354740
Pubmed

Genetically determined high activity of IL-12 and IL-18 in ulcerative colitis and TLR5 in Crohns disease were associated with non-response to anti-TNF therapy.

IL18 TLR5

2.28e-06253228139755
Pubmed

Absence of complement factor H reduces physical performance in C57BL6 mice.

CFH CFHR4

2.28e-06253232962822
Pubmed

Dietary induction of colonic tumors in a mouse model of sporadic colon cancer.

APC MUC2

2.28e-06253218829535
Pubmed

Transgenic mice expressing variants of complement factor H develop AMD-like retinal findings.

CFH CFHR4

2.28e-06253220538999
Pubmed

Inheritance, hormonal regulation and properties of polymorphic murine antigens Mud1 and Mud2.

CFH CFHR4

2.28e-0625324992636
Pubmed

Retinal changes precede visual dysfunction in the complement factor H knockout mouse.

CFH CFHR4

2.28e-06253223844226
Pubmed

Differential role for CD277 as a co-regulator of the immune signal in T and NK cells.

BTN3A2 BTN3A1

2.28e-06253221918970
Pubmed

The molecular basis for modulation of human Vγ9Vδ2 T cell responses by CD277/butyrophilin-3 (BTN3A)-specific antibodies.

BTN3A2 BTN3A1

2.28e-06253222846996
Pubmed

Prediction from sequence comparisons of residues of factor H involved in the interaction with complement component C3b.

CFH CFHR4

2.28e-0625328615824
Pubmed

Cadmium Induces Glomerular Endothelial Cell-Specific Expression of Complement Factor H via the -1635 AP-1 Binding Site.

CFH CFHR4

2.28e-06253230642982
Pubmed

Partial Complement Factor H Deficiency Associates with C3 Glomerulopathy and Thrombotic Microangiopathy.

CFH CFHR4

2.28e-06253226374608
Pubmed

Pre-synaptic and post-synaptic localization of EphA4 and EphB2 in adult mouse forebrain.

EPHB2 EPHA4

2.28e-06253218410519
Pubmed

A gene locus concerned with an antigenic serum substance in Mus musculus.

CFH CFHR4

2.28e-0625324955525
Pubmed

Analysis of complement factor H mRNA expression: dexamethasone and IFN-gamma increase the level of H in L cells.

CFH CFHR4

2.28e-0625322533512
Pubmed

Complement factor H: spatial and temporal expression and localization in the eye.

CFH CFHR4

2.28e-06253216936129
Pubmed

Watching synchronous mitochondrial respiration in the retina and its instability in a mouse model of macular degeneration.

CFH CFHR4

2.28e-06253233558624
Pubmed

Genome-Wide Association Study Reveals Variants in CFH and CFHR4 Associated with Systemic Complement Activation: Implications in Age-Related Macular Degeneration.

CFH CFHR4

2.28e-06253229398083
Pubmed

Complement factor H Y402H polymorphism results in diminishing CD4+ T cells and increasing C-reactive protein in plasma.

CFH CFHR4

2.28e-06253237940659
Pubmed

Comparative analysis of the properties and ligand binding characteristics of CspZ, a factor H binding protein, derived from Borrelia burgdorferi isolates of human origin.

CFH CFHR4

2.28e-06253219620346
Pubmed

Winnie-APCMin/+ Mice: A Spontaneous Model of Colitis-Associated Colorectal Cancer Combining Genetics and Inflammation.

APC MUC2

2.28e-06253232340123
Pubmed

Complement factor H regulates retinal development and its absence may establish a footprint for age related macular degeneration.

CFH CFHR4

2.28e-06253230705315
Pubmed

Interaction of Muc2 and Apc on Wnt signaling and in intestinal tumorigenesis: potential role of chronic inflammation.

APC MUC2

2.28e-06253218794118
Pubmed

Loss of single immunoglobulin interlukin-1 receptor-related molecule leads to enhanced colonic polyposis in Apc(min) mice.

SIGIRR APC

2.28e-06253220416302
Pubmed

A complement factor H homolog, heparan sulfation, and syndecan maintain inversin compartment boundaries in C. elegans cilia.

CFH CFHR4

2.28e-06253233859044
Pubmed

Regulation of age-related macular degeneration-like pathology by complement factor H.

CFH CFHR4

2.28e-06253225991857
Pubmed

Structural basis for autoinhibition of the Ephb2 receptor tyrosine kinase by the unphosphorylated juxtamembrane region.

EPHB2 EPHA4

2.28e-06253211572780
Pubmed

Overlapping DNA methylation dynamics in mouse intestinal cell differentiation and early stages of malignant progression.

EPHB2 APC

2.28e-06253225933092
Pubmed

Overexpression of EphA4 gene and reduced expression of EphB2 gene correlates with liver metastasis in colorectal cancer.

EPHB2 EPHA4

2.28e-06253218695888
Pubmed

Canonical wnt signaling regulates hematopoiesis in a dosage-dependent fashion.

APC AXIN2

2.28e-06253221982234
Pubmed

Genetic variation in CFH predicts phenytoin-induced maculopapular exanthema in European-descent patients.

CFH CFHR4

2.28e-06253229288229
Pubmed

Tumour extracellular vesicle-derived Complement Factor H promotes tumorigenesis and metastasis by inhibiting complement-dependent cytotoxicity of tumour cells.

CFH CFHR4

2.28e-06253233708358
Pubmed

Serological survey of complement factor H in common laboratory and wild mice: a new third allotype.

CFH CFHR4

2.28e-0625322522412
Pubmed

Absence of complement factor H alters bone architecture and dynamics.

CFH CFHR4

2.28e-06253230107932
Pubmed

Early changes in hippocampal Eph receptors precede the onset of memory decline in mouse models of Alzheimer's disease.

EPHB2 EPHA4

2.28e-06253219542617
Pubmed

Murine Factor H Co-Produced in Yeast With Protein Disulfide Isomerase Ameliorated C3 Dysregulation in Factor H-Deficient Mice.

CFH CFHR4

2.28e-06253234054871
Pubmed

Factor H binding to PspC of Streptococcus pneumoniae increases adherence to human cell lines in vitro and enhances invasion of mouse lungs in vivo.

CFH CFHR4

2.28e-06253217562771
Pubmed

Aged complement factor H knockout mice kept in a clean barriered environment have reduced retinal pathology.

CFH CFHR4

2.28e-06253227397653
Pubmed

Effect of Anti-C5a Therapy in a Murine Model of Early/Intermediate Dry Age-Related Macular Degeneration.

CFH CFHR4

2.28e-06253229392311
Pubmed

The critical role of complement alternative pathway regulator factor H in allergen-induced airway hyperresponsiveness and inflammation.

CFH CFHR4

2.28e-06253222174452
Pubmed

Loss of Complement Factor H in Plasma Increases Endothelial Cell Migration.

CFH CFHR4

2.28e-06253228819420
Pubmed

Complement factor H genotypes impact risk of age-related macular degeneration by interaction with oxidized phospholipids.

CFH CFHR4

2.28e-06253222875704
Pubmed

Local complement factor H protects kidney endothelial cell structure and function.

CFH CFHR4

2.28e-06253234139209
Pubmed

Systemic administration of Abeta mAb reduces retinal deposition of Abeta and activated complement C3 in age-related macular degeneration mouse model.

CFH CFHR4

2.28e-06253223799019
Pubmed

Circulating FH Protects Kidneys From Tubular Injury During Systemic Hemolysis.

CFH CFHR4

2.28e-06253232849636
Pubmed

Complement factor h is critical in the maintenance of retinal perfusion.

CFH CFHR4

2.28e-06253219541934
Pubmed

Complement factor H deficiency in aged mice causes retinal abnormalities and visual dysfunction.

CFH CFHR4

2.28e-06253217921253
Pubmed

The role of complement dysregulation in AMD mouse models.

CFH CFHR4

2.28e-06253224664701
Pubmed

Mitochondrial decline precedes phenotype development in the complement factor H mouse model of retinal degeneration but can be corrected by near infrared light.

CFH CFHR4

2.28e-06253226149919
Pubmed

The roles of Eph receptors in contextual fear conditioning memory formation.

EPHB2 EPHA4

2.28e-06253226165136
Pubmed

Murine protein H is comprised of 20 repeating units, 61 amino acids in length.

CFH CFHR4

2.28e-0625322940596
Pubmed

A receptor for the complement regulator factor H increases transmission of trypanosomes to tsetse flies.

CFH CFHR4

2.28e-06253232165615
Pubmed

Death by color: differential cone loss in the aging mouse retina.

CFH CFHR4

2.28e-06253224929970
Pubmed

Cfh genotype interacts with dietary glycemic index to modulate age-related macular degeneration-like features in mice.

CFH CFHR4

2.28e-06253224370827
Pubmed

CD277 is a negative co-stimulatory molecule universally expressed by ovarian cancer microenvironmental cells.

BTN3A2 BTN3A1

2.28e-06253221113407
Pubmed

PKCalpha tumor suppression in the intestine is associated with transcriptional and translational inhibition of cyclin D1.

APC MUC2

2.28e-06253219232344
Pubmed

Essential role of surface-bound complement factor H in controlling immune complex-induced arthritis.

CFH CFHR4

2.28e-06253223436934
Pubmed

Treatment with 670 nm light up regulates cytochrome C oxidase expression and reduces inflammation in an age-related macular degeneration model.

CFH CFHR4

2.28e-06253223469078
Pubmed

Topical cyclodextrin reduces amyloid beta and inflammation improving retinal function in ageing mice.

CFH CFHR4

2.28e-06253225921262
Pubmed

Complement factor h limits immune complex deposition and prevents inflammation and scarring in glomeruli of mice with chronic serum sickness.

CFH CFHR4

2.28e-06253215574507
Pubmed

The proprotein convertase PC5/6 is protective against intestinal tumorigenesis: in vivo mouse model.

PCSK5 APC

2.28e-06253219737405
Pubmed

Design and evaluation of meningococcal vaccines through structure-based modification of host and pathogen molecules.

CFH CFHR4

2.28e-06253223133374
Pubmed

Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors.

APC AXIN2

2.28e-06253211809809
Pubmed

Human complement factor H Y402H polymorphism causes an age-related macular degeneration phenotype and lipoprotein dysregulation in mice.

CFH CFHR4

2.28e-06253230808757
Pubmed

Binding of factor H to tubular epithelial cells limits interstitial complement activation in ischemic injury.

CFH CFHR4

2.28e-06253221544060
Pubmed

Role of ocular complement factor H in a murine model of choroidal neovascularization.

CFH CFHR4

2.28e-06253220813971
Pubmed

Location of the mouse complement factor H gene (cfh) by FISH analysis and replication R-banding.

CFH CFHR4

2.28e-0625321486806
Pubmed

A chimeric Cfh transgene leads to increased retinal oxidative stress, inflammation, and accumulation of activated subretinal microglia in mice.

CFH CFHR4

2.28e-06253226030099
Pubmed

Spontaneous hemolytic uremic syndrome triggered by complement factor H lacking surface recognition domains.

CFH CFHR4

2.28e-06253217517971
Pubmed

Treatment with human complement factor H rapidly reverses renal complement deposition in factor H-deficient mice.

CFH CFHR4

2.28e-06253220445496
Pubmed

Possible role of complement factor H in podocytes in clearing glomerular subendothelial immune complex deposits.

CFH CFHR4

2.28e-06253231133737
Pubmed

High-density lipoproteins are a potential therapeutic target for age-related macular degeneration.

CFH CFHR4

2.28e-06253232737203
Pubmed

Distinct and separable roles of the complement system in factor H-deficient bone marrow chimeric mice with immune complex disease.

CFH CFHR4

2.28e-06253216597679
Pubmed

AAV Gene Augmentation of Truncated Complement Factor H Differentially Rescues Ocular Complement Dysregulation in a Mouse Model.

CFH CFHR4

2.28e-06253237471073
Pubmed

Complement Factor H Serum Levels Determine Resistance to Pneumococcal Invasive Disease.

CFH CFHR4

2.28e-06253226802141
Pubmed

Expression of human complement factor H prevents age-related macular degeneration-like retina damage and kidney abnormalities in aged Cfh knockout mice.

CFH CFHR4

2.28e-06253225447048
Pubmed

Structure of the murine complement factor H gene.

CFH CFHR4

2.28e-0625322972715
Pubmed

Complement factor H deficiency combined with smoking promotes retinal degeneration in a novel mouse model.

CFH CFHR4

2.28e-06253234775843
Pubmed

A 1.1-Mb transcript map of the hereditary hemochromatosis locus.

BTN3A3 BTN3A2 BTN3A1

2.68e-06185339149941
Pubmed

Transient expression of ephrin b2 in perinatal skin is required for maintenance of keratinocyte homeostasis.

EPHB2 IL18 EPHA4

5.79e-062353319571816
Pubmed

Genetic contributions of nonautoimmune SWR mice toward lupus nephritis.

CFH APC CFHR4

6.61e-062453311739537
Pubmed

Uncontrolled C3 activation causes membranoproliferative glomerulonephritis in mice deficient in complement factor H.

CFH CFHR4

6.83e-06353212091909
Pubmed

Deletion of TNF in Winnie-APCMin/+ Mice Reveals Its Dual Role in the Onset and Progression of Colitis-Associated Colorectal Cancer.

APC MUC2

6.83e-06353236499472
Pubmed

Borrelia burgdorferi binding of host complement regulator factor H is not required for efficient mammalian infection.

CFH CFHR4

6.83e-06353217420242
Pubmed

Complement Regulatory Protein Factor H Is a Soluble Prion Receptor That Potentiates Peripheral Prion Pathogenesis.

CFH CFHR4

6.83e-06353229070671
Pubmed

Altered expression patterns of complement factor H and miR-146a genes in acute-chronic phases in experimental autoimmune encephalomyelitis mouse.

CFH CFHR4

6.83e-06353230972735
Pubmed

Retinal Basal Laminar Deposits in Complement fH/fP Mouse Model of Dense Deposit Disease.

CFH CFHR4

6.83e-06353230025090
Pubmed

Comparison of surface recognition and C3b binding properties of mouse and human complement factor H.

CFH CFHR4

6.83e-06353216023208
Pubmed

Location of theSas-1 locus on mouse chromosome 1.

CFH CFHR4

6.83e-06353221302086
InteractionBTN3A1 interactions

BTN3A3 BTN3A2 BTN3A1

2.31e-0523493int:BTN3A1
InteractionBTN3A3 interactions

BTN3A3 BTN3A2 BTN3A1

3.38e-0526493int:BTN3A3
InteractionBTN3A2 interactions

BTN3A3 BTN3A2 BTN3A1

3.38e-0526493int:BTN3A2
Cytoband22q11.2

IGLV2-18 IGLV2-14 IGLV2-11 IGLV2-8 IGLV6-57

2.91e-0712053522q11.2
CytobandEnsembl 112 genes in cytogenetic band chr22q11

IGLV2-18 IGLV2-14 IGLV2-11 IGLV2-8 MICAL3 IGLV6-57

8.91e-06419536chr22q11
Cytoband1q32

CFH CFHR4

1.49e-03495321q32
CytobandEnsembl 112 genes in cytogenetic band chr1q31

CFH CFHR4

3.44e-0375532chr1q31
CytobandEnsembl 112 genes in cytogenetic band chr1q41

SUSD4 TLR5

5.23e-0393532chr1q41
GeneFamilyImmunoglobulin lambda locus at 22q11.2

IGLV2-18 IGLV2-14 IGLV2-11 IGLV2-8 IGLV6-57

1.90e-0689425353
GeneFamilyButyrophilins|V-set domain containing|C2-set domain containing

BTN3A3 BTN3A2 BTN3A1

5.20e-0615423458
GeneFamilyHyalectan proteoglycans|V-set domain containing|Sushi domain containing|C-type lectin domain containing

CFH SUSD4 SVEP1 CFHR4

9.09e-06574241179
GeneFamilyFibronectin type III domain containing|Sterile alpha motif domain containing|EPH receptors

EPHB2 EPHA4

4.71e-04144221095
GeneFamilyImmunoglobulin like domain containing

SIGIRR IGSF1 MILR1 TMEM81

1.03e-03193424594
GeneFamilyCD molecules|Mucins

MUC19 MUC2

1.08e-0321422648
GeneFamilyComplement system|Sushi domain containing

CFH CFHR4

3.16e-0336422492
GeneFamilyAdenosine receptors|V-set domain containing

BTN3A3 BTN3A2 BTN3A1

6.38e-03163423590
CoexpressionSMID_BREAST_CANCER_NORMAL_LIKE_UP

CFH PCSK5 IGLV2-14 BTN3A3 NRXN1 BTN3A2 SVEP1 EPHA4

4.11e-06485518M8513
CoexpressionIVANOVA_HEMATOPOIESIS_STEM_CELL

NRXN1 ETV1 DNAJC21 PEAK1 PAIP1

3.67e-05193515M6813
CoexpressionGSE18893_TCONV_VS_TREG_2H_TNF_STIM_DN

CEP350 BTN3A3 BTN3A2 BTN3A1 EPHA4

3.76e-05194515M7306
CoexpressionIVANOVA_HEMATOPOIESIS_STEM_CELL

NRXN1 ETV1 DNAJC21 PEAK1 PAIP1

3.95e-05196515MM667
CoexpressionGSE7548_DAY7_VS_DAY28_PCC_IMMUNIZATION_CD4_TCELL_DN

CFH BTN3A3 BTN3A2 BTN3A1 SVEP1

4.24e-05199515M6843
CoexpressionWEIGEL_OXIDATIVE_STRESS_BY_HNE_AND_H2O2

IL18 APC PAIP1

4.74e-0536513M347
CoexpressionHE_LIM_SUN_FETAL_LUNG_C0_MYOFIBROBLAST_2_CELL

PCSK5 SSC5D ABR IGSF1

5.06e-05104514M45682
CoexpressionCUI_TCF21_TARGETS_UP

CFH EPHA4 CFHR4

5.15e-0537513MM1171
CoexpressionDESCARTES_ORGANOGENESIS_DEFINITIVE_ERYTHROID_LINEAGE

BTN3A3 BTN3A2 BTN3A1

9.93e-0546513MM3654
CoexpressionCASTELLANO_HRAS_AND_NRAS_TARGETS_UP

CFH CFHR4

1.03e-048512MM1086
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-6689_k-means-cluster#5_top-relative-expression-ranked_500

CEP350 ETV1 APC PAIP1 EPHA4

3.86e-05165495DevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-6689_k5_500
CoexpressionAtlasAravindRamakr_StemCell-HD_top-relative-expression-ranked_1000_k-means-cluster#3

IGLV2-18 IGLV2-14 IGLV2-11 IGLV2-8 MUC2

6.31e-05183495Arv_SC-HD_1000_K3
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_k-means-cluster#5_top-relative-expression-ranked_500

CEP350 ETV1 APC PAIP1 EPHA4

8.32e-05194495DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_k5_500
ToppCellnormal_Lung-B_lymphocytes-MALT_B_cells|normal_Lung / Location, Cell class and cell subclass

IGLV2-18 IGLV2-14 IGLV2-11 IGLV2-8 IGLV6-57

1.18e-06159525fbd0131b66f4267f7b0d6c3ad874ad097b859074
ToppCellhealthy_donor-Lymphocytic-Plasma_cell-IgM_Plasmablast|healthy_donor / Disease condition, Lineage, Cell class and subclass

IGLV2-18 IGLV2-14 IGLV2-11 IGLV2-8 IGLV6-57

1.45e-061665252b7b580bec8d9467b0deaf97098065f72dbf2a4f
ToppCell10x5'-GI_large-bowel|World / Manually curated celltypes from each tissue

IGLV2-18 IGLV2-11 IGLV2-8 MUC2 IGLV6-57

1.54e-061685251290c909655bc37f6b8bf216d18127a21b99e9c0
ToppCell10x5'-Lung-Lymphocytic_B-Memory_B_cells|Lung / Manually curated celltypes from each tissue

IGLV2-14 IGLV2-11 IGLV2-8 MICAL3 MUC2

1.73e-061725252cb2dc7cfd6db5a98a393b1a84c23abf3d692a53
ToppCellPBMC-Control-Lymphocyte-B-Plasmablast-Plasmablast-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

IGLV2-18 IGLV2-14 IGLV2-11 IGLV2-8 IGLV6-57

1.99e-061775254c434a7b7cc54cf4dac996bbc3f5124d9ef9a9cd
ToppCellPBMC-Control-Lymphocyte-B-Plasmablast-Plasmablast|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

IGLV2-18 IGLV2-14 IGLV2-11 IGLV2-8 IGLV6-57

1.99e-06177525d746122bf8d208c3aa4d156e8c12d0a0e555c6e5
ToppCellPBMC-Control-Lymphocyte-B-Plasmablast|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

IGLV2-18 IGLV2-14 IGLV2-11 IGLV2-8 IGLV6-57

1.99e-06177525fc40918825b7e1eb6861df59dfca944778a64b98
ToppCellPBMC-Control-Lymphocyte-B-Plasmablast|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

IGLV2-18 IGLV2-14 IGLV2-11 IGLV2-8 IGLV6-57

2.11e-06179525837ed81f18257f444eaeadc4fac89deedd4e3061
ToppCellPBMC-Control-Lymphocyte-B-Plasmablast-Plasmablast-Plasmablast|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

IGLV2-18 IGLV2-14 IGLV2-11 IGLV2-8 IGLV6-57

2.11e-06179525494febe77c6d4e6a2c6f0928bbf4c84b0301f188
ToppCellPBMC-Control-Lymphocyte-B-Plasmablast-Plasmablast|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

IGLV2-18 IGLV2-14 IGLV2-11 IGLV2-8 IGLV6-57

2.11e-06179525b6ee4f41d8fb5f047b7bdd8489dda0a89fc6d43f
ToppCell3'-Broncho-tracheal-Immune_Lymphocytic-Lymphocytic_B-plasma_cell-Plasma_cells-Plasma_cells_L.1.7.0.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IGLV2-18 IGLV2-14 IGLV2-11 IGLV2-8 IGLV6-57

2.16e-06180525cea079bc02e08c46600eed05ab9924ec90e1e3d3
ToppCell3'-Broncho-tracheal-Immune_Lymphocytic-Lymphocytic_B-plasma_cell-Plasma_cells|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IGLV2-18 IGLV2-14 IGLV2-11 IGLV2-8 IGLV6-57

2.41e-0618452515f2c10101ccc8ed059520fc082ee42593dff269
ToppCell3'-Broncho-tracheal-Immune_Lymphocytic-Lymphocytic_B-plasma_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IGLV2-18 IGLV2-14 IGLV2-11 IGLV2-8 IGLV6-57

2.41e-06184525a90a58d9e319afa1cd572e4c2f516fadc42f56e5
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Immune-Lymphocytic_B-Plasma_Cell-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

IGLV2-18 IGLV2-14 IGLV2-11 IGLV2-8 IGLV6-57

2.47e-061855250fff2608f507e019ebb69c27e58fd5be3b049bef
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Immune-Lymphocytic_B-Plasma_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

IGLV2-18 IGLV2-14 IGLV2-11 IGLV2-8 IGLV6-57

2.47e-0618552579edc1eeb7b5b9123961ac3ecf398ee68d9dddb9
ToppCell5'-Adult-LargeIntestine-Hematopoietic-Plasma_cells|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

IGLV2-18 IGLV2-14 IGLV2-11 IGLV2-8 IGLV6-57

2.82e-0619052579ee6d10dfbb775da149a1104da5823cf63bbb46
ToppCell5'-Adult-LargeIntestine-Hematopoietic-Plasma_cells-IgA_plasma_cell|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

IGLV2-18 IGLV2-14 IGLV2-11 IGLV2-8 IGLV6-57

2.82e-0619052518762ce78ed0b206ade19e1c8ff76a2647489f68
ToppCell5'-Adult-LargeIntestine-Hematopoietic|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

IGLV2-18 IGLV2-14 IGLV2-11 IGLV2-8 IGLV6-57

2.89e-06191525d1d30279ed4612b4f62c225d9eabf0b8a7a09d11
ToppCellParenchymal-10x3prime_v2-Immune_Lymphocytic-B-B_plasma-B_plasma_IgA|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

IGLV2-18 IGLV2-14 IGLV2-11 IGLV2-8 IGLV6-57

2.97e-061925253dddfc93c3c954c4416c7c1f1f161e4d1dcc1233
ToppCellTracheal-10x5prime-Immune_Lymphocytic-B-B_plasma-B_plasma_IgG|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

IGLV2-18 IGLV2-14 IGLV2-11 IGLV2-8 IGLV6-57

3.12e-06194525a4a70369541876e1192df8828b63e3d1746ae3d9
ToppCellMonocytes-M2-like_CD16+_macrophages|World / Immune cells in Kidney/Urine in Lupus Nephritis

EPHB2 LGMN IL18 TLR5 MILR1

3.20e-0619552510fa47bdcf6c9784ea930b75a5861e139421feed
ToppCell5'-Adult-LargeIntestine|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

IGLV2-14 IGLV2-11 IGLV2-8 MUC2 IGLV6-57

3.20e-06195525600174e35574fe7c44dd923adcf43686e7b01e39
ToppCellfacs-Lung-3m-Mesenchymal-myofibroblast-myofibroblast_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PCSK5 SSC5D KCNS3 TDO2 AXIN2

3.20e-06195525c6bb16c0076639c6ddef1a15d8cba44bc29c077d
ToppCellfacs-Lung-3m-Mesenchymal-myofibroblast-myofibroblast_cell-pulmonary_interstitial_myofibroblast|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PCSK5 SSC5D KCNS3 TDO2 AXIN2

3.20e-06195525ea89f80d3d7e9f737442f7c1aa1791d277ffc90c
ToppCellCOVID_vent-Lymphocytic-Plasma_cell-IgM_Plasmablast|COVID_vent / Disease condition, Lineage, Cell class and subclass

IGLV2-18 IGLV2-14 IGLV2-11 IGLV2-8 IGLV6-57

3.28e-06196525026a06d8d2089806823e6f6453d3ede84ae93bc6
ToppCellBiopsy_IPF-Immune-Plasma_cells|Biopsy_IPF / Sample group, Lineage and Cell type

IGLV2-18 IGLV2-14 IGLV2-11 IGLV2-8 IGLV6-57

3.28e-06196525a1b6a8000b86efcb07843998aa3a49bb1f54bcda
ToppCell368C-Fibroblasts-Fibroblast-G|368C / Donor, Lineage, Cell class and subclass (all cells)

CFH ETV1 KCNS3 TDO2 SVEP1

3.36e-06197525156155c2f0c1a2461e45803da578af18ee221660
ToppCellCOVID_non-vent-Lymphocytic-T_cell-CD8+_Memory_T_cell|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

CFH BTN3A3 SIGIRR BTN3A2 BTN3A1

3.36e-06197525836061acd7f0d5de89b16f52ec679bdf09eac9db
ToppCell368C-Fibroblasts-Fibroblast-G-|368C / Donor, Lineage, Cell class and subclass (all cells)

CFH ETV1 KCNS3 TDO2 SVEP1

3.36e-06197525d5d9263451f6c10cb3b9c17740183ca334e24851
ToppCellCOVID_non-vent-Lymphocytic-Plasma_cell-IgA_Plasmablast|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

IGLV2-18 IGLV2-14 IGLV2-11 IGLV2-8 IGLV6-57

3.36e-06197525fdbf4eb9fa5aefb4ffb307494fe4774bf5e0aaeb
ToppCellBronchial-10x5prime-Stromal-Fibroblastic-Fibro_peribronchial|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

CFH SSC5D ETV1 TDO2 SVEP1

3.53e-06199525e1f1950d6f840485e263b83dc81b98910be3ae7a
ToppCellParenchymal-10x5prime-Stromal-Peri/Epineurial_|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

EPHB2 HOXA6 CFH SSC5D IGLV2-14

3.62e-062005254c3c11dd5e71ebc3d62264eeaeb71a850b149779
ToppCellEntopeduncular-Macroglia-POLYDENDROCYTE-P2-Tnr|Entopeduncular / BrainAtlas - Mouse McCarroll V32

MYCL TLR5 OCA2 SLC4A11

3.77e-06905246adc78899a08d48da8ed4618ecf866c9ed9be059
ToppCellEntopeduncular-Macroglia-POLYDENDROCYTE-P2-Tnr-Polydendrocyte.Tnr.Bmp4_(Bmp4)|Entopeduncular / BrainAtlas - Mouse McCarroll V32

MYCL TLR5 OCA2 SLC4A11

3.77e-0690524a74f8172780adc1410e36e2718412010ee0ebf1f
ToppCellEntopeduncular-Macroglia-POLYDENDROCYTE-P2-Tnr-Polydendrocyte.Tnr.Bmp4_(Bmp4)-|Entopeduncular / BrainAtlas - Mouse McCarroll V32

MYCL TLR5 OCA2 SLC4A11

3.77e-0690524909ad62d175b657d8e541b0981ce8fed0ba7ed6c
ToppCellEntopeduncular-Macroglia-POLYDENDROCYTE-P2|Entopeduncular / BrainAtlas - Mouse McCarroll V32

MYCL TLR5 OCA2 SLC4A11

3.77e-0690524936c5078677ec934f3049d8aa5a14d930aa2e6dc
ToppCellE18.5-samps-Mesenchymal-Myofibroblast-myofibroblast_-_mature_-_B|E18.5-samps / Age Group, Lineage, Cell class and subclass

KCNS3 ZNF598 EPHA4 TMEM81

1.99e-05137524b553958e7e6dcd887d860e34d3983cbb85cefaa6
ToppCellmetastatic_Lymph_Node-B_lymphocytes-Plasma_cells|metastatic_Lymph_Node / Location, Cell class and cell subclass

IGLV2-14 IGLV2-8 TLL2 IGLV6-57

2.29e-051425245ba3a33c2ee20be8baaed97536ca6e9d1de6752f
ToppCellfacs-Brain_Non-Myeloid-Hippocampus_-18m-Epithelial-neuronal_stem_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPHB2 MYCL SUSD4 TLR5

2.84e-0515052447ea08d7609e1d2382bf56ef9e5c767e3597cf93
ToppCellPND07-Immune-Immune_Myeloid-Monocytic-Macrophage-IM-IM_prolif|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LGMN IL18 TLR5 MILR1

3.23e-0515552493bfcf5c12cbb61a1e0444312afd2aa411a8bf50
ToppCellBAL-Mild-Lymphocyte-B-Plasmablast-Plasmablast-Plasmablast|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

IGLV2-14 IGLV2-11 IGLV2-8 IGLV6-57

3.31e-051565245d9e1df70f2e9219f6b029be2e39297605d36726
ToppCell343B-Lymphocytic-Plasma_cell-|343B / Donor, Lineage, Cell class and subclass (all cells)

IGLV2-18 IGLV2-14 IGLV2-8 IGLV6-57

3.39e-05157524554ddbaf83f5d6eb4669c673efdbb28fd87e2ba8
ToppCell343B-Lymphocytic-Plasma_cell|343B / Donor, Lineage, Cell class and subclass (all cells)

IGLV2-18 IGLV2-14 IGLV2-8 IGLV6-57

3.39e-051575242cb3deb5313ce734710c601935ca318e4179077e
ToppCellBAL-Mild-Lymphocyte-B-Plasmablast-Plasmablast|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

IGLV2-14 IGLV2-11 IGLV2-8 IGLV6-57

3.48e-0515852417a13c5719eb363f2eb8f1d4e171429c6a1ce1e9
ToppCellBAL-Mild-Lymphocyte-B-Plasmablast-Plasmablast-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

IGLV2-14 IGLV2-11 IGLV2-8 IGLV6-57

3.48e-051585241397078f909338fa5fa3b01748db891e5e3fc9e7
ToppCellBAL-Mild-Lymphocyte-B-Plasmablast|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

IGLV2-14 IGLV2-11 IGLV2-8 IGLV6-57

3.48e-05158524e5451cfe67e882eb0c1eca287740f8ab75370abc
ToppCellBAL-Mild-Lymphocyte-B-Plasmablast-Plasmablast|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

IGLV2-14 IGLV2-11 IGLV2-8 IGLV6-57

3.56e-051595246ecc3cb2daa5887b59836842be414a00cdcdaeec
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

EPHB2 MYCL CFH SLC4A11

3.56e-051595249f6607e395bcca9cb1c83199bdbbaaa62a93938d
ToppCellBAL-Mild-Lymphocyte-B-Plasmablast|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

IGLV2-14 IGLV2-11 IGLV2-8 IGLV6-57

3.56e-051595241827493fb464bbddb2ee23f99472cfbcaf57405b
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

EPHB2 MYCL CFH SLC4A11

3.56e-05159524c8b42ebc25ebcc450832096fbffaa5c5f5fe88e7
ToppCellMild-Lymphoid-Plasma|Mild / Condition, Lineage, Cell class and cell subclass

IGLV2-14 IGLV2-11 IGLV2-8 IGLV6-57

3.65e-051605247fdb849f5caf5a127a2582326215e11f8eb4fa0e
ToppCellMild-Lymphoid-Plasma-|Mild / Condition, Lineage, Cell class and cell subclass

IGLV2-14 IGLV2-11 IGLV2-8 IGLV6-57

3.65e-05160524aa79848913910c01249d6cacf4ed53ec0e4f5c3d
ToppCellMild_COVID-19-B_cell-Plasmablast|Mild_COVID-19 / Disease group,lineage and cell class (2021.01.30)

IGLV2-14 IGLV2-11 IGLV2-8 IGLV6-57

3.83e-05162524b67f6fb3d7f6093c8ef02398ff8fea4d0fb41a3b
ToppCell10x_3'_v3-blood_(10x_3'_v3)-myeloid-myeloid_dendritic|blood_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

HOXA6 CFH KLHL13 MUC2

3.83e-05162524233011408f022647932c81ebab78f9813e3c6833
ToppCell367C-Lymphocytic-Plasma_cell-|367C / Donor, Lineage, Cell class and subclass (all cells)

IGLV2-14 IGLV2-11 IGLV2-8 IGLV6-57

4.31e-05167524f2185eb72f0137136f6d71af2a70168fded6c940
ToppCell367C-Lymphocytic-Plasma_cell|367C / Donor, Lineage, Cell class and subclass (all cells)

IGLV2-14 IGLV2-11 IGLV2-8 IGLV6-57

4.31e-051675245e768cf24699893e05d1bcb1c92dba2336943a64
ToppCell10x_3'_v3-spleen_(10x_3'_v3)-myeloid-myeloid_dendritic-plasmacytoid_dendritic_cell|spleen_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

IGLV2-14 IGLV2-11 IGLV2-8 IGLV6-57

4.31e-05167524afb6d0993f3fd44a295874673055189d514f7b11
ToppCell10x5'-Lung-Lymphocytic_B_plasma-Plasma_cells|Lung / Manually curated celltypes from each tissue

IGLV2-14 IGLV2-11 IGLV2-8 IGLV6-57

4.42e-05168524e8bd090de5c9fe286b08a8b314ce12cf988184f0
ToppCellBAL-Mild-Lymphocyte-B|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

IGLV2-14 IGLV2-11 IGLV2-8 IGLV6-57

4.52e-05169524307571e57c3bfdf15f0fe1a8b36585e8e4f8a207
ToppCell3'-Child04-06-SmallIntestine-Hematopoietic-Plasma_cells-IgG_plasma_cell|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

IGLV2-14 IGLV2-11 IGLV2-8 IGLV6-57

4.52e-051695240c2384f780ec25710ebb35c0b0df8f4afb53c9b1
ToppCellE16.5-Immune-Immune_Myeloid-Monocytic-Macrophage|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CFH LGMN IL18 MILR1

4.52e-051695246dfc4e3f1ce9d477400a416ba6069b59f14ca1b8
ToppCell5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CFH TDO2 SVEP1 CFHR4

4.52e-05169524c0824a93674e2bff0f09b2d2fab5bab016a2e379
ToppCelltumor_Lung-B_lymphocytes-Plasma_cells|tumor_Lung / Location, Cell class and cell subclass

IGLV2-14 IGLV2-11 IGLV2-8 IGLV6-57

4.52e-05169524b36b7632ce55fc7b6b8b66020563d360b3de6fd7
ToppCell10x5'-Lung-Lymphocytic_B_plasma|Lung / Manually curated celltypes from each tissue

IGLV2-14 IGLV2-11 IGLV2-8 IGLV6-57

4.84e-051725248156fb6de66a4c92ade703b71c2e9187291e50ef
ToppCell3'_v3-bone_marrow-Lymphocytic_B_plasma-Plasma_cells|bone_marrow / Manually curated celltypes from each tissue

IGLV2-14 IGLV2-11 IGLV2-8 IGLV6-57

5.18e-0517552451301f3f44d3e88397f367cedd1e2abaa2be4c6f
ToppCell10x_3'_v2v3-Non-neoplastic-Lymphoid-Plasma_B-Plasma_B|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

IGLV2-14 IGLV2-11 IGLV2-8 IGLV6-57

5.29e-0517652467d6dc38708692f8c58cea5ed896f10718e9ffa6
ToppCell10x_3'_v2v3-Non-neoplastic-Lymphoid-Plasma_B|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

IGLV2-14 IGLV2-11 IGLV2-8 IGLV6-57

5.29e-05176524125be81311f87563ca321472fcce6e0e0ae24c16
ToppCellControl-Lymphoid_P-Plasmablast|Control / Disease group, lineage and cell class

IGLV2-18 IGLV2-14 IGLV2-11 IGLV2-8

5.29e-051765244b4416f342b732d2cc60133838728880326257d8
ToppCellControl-Lymphoid_P|Control / Disease group, lineage and cell class

IGLV2-18 IGLV2-14 IGLV2-11 IGLV2-8

5.29e-05176524d895a6b295cd649273ff80ad7785a3e0ae4c728a
ToppCellkidney_cells-Hypertensive_with+without-CKD-Immune-Lymphocytic_B-Plasma_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

IGLV2-14 IGLV2-11 IGLV2-8 IGLV6-57

5.41e-05177524c2b0fb5921eea24d248d6e6ccb57c29b0832602c
ToppCell(2)_Plasma_cells|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

IGLV2-14 IGLV2-11 IGLV2-8 IGLV6-57

5.41e-05177524ed3c936bb69f9bc7291b4f6cde1d204078117c48
ToppCellkidney_cells-Hypertensive_with+without-CKD-Immune-Lymphocytic_B-Plasma_Cell-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

IGLV2-14 IGLV2-11 IGLV2-8 IGLV6-57

5.41e-05177524111fb0707ff37ca631d85bb5a09e067ffe568eb8
ToppCellHealthy-Plasmablast|Healthy / disease group, cell group and cell class

IGLV2-14 IGLV2-11 IGLV2-8 IGLV6-57

5.41e-051775244ff75c609ac9edf7a94bda42eb7124c559e8b6aa
ToppCelltumor_Lung-B_lymphocytes-MALT_B_cells|tumor_Lung / Location, Cell class and cell subclass

IGLV2-14 IGLV2-11 IGLV2-8 IGLV6-57

5.41e-0517752437e03f51925345f5f716ef3abe1d2c4ccf129020
ToppCellPND07-Immune-Immune_Myeloid-Monocytic-Macrophage-IM|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CFH LGMN IL18 MILR1

5.65e-05179524fae869fb0a91428481bf8a9c111dcc639e2b4278
ToppCell5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_B-plasma_cell-Plasma_cells-Plasma_cells_L.1.7.1.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IGLV2-18 IGLV2-11 IGLV2-8 IGLV6-57

5.77e-05180524e3877f6ef5f54ff689058b4c996ab1851822f871
ToppCell356C-Lymphocytic-Plasma_cell|356C / Donor, Lineage, Cell class and subclass (all cells)

IGLV2-14 IGLV2-11 IGLV2-8 IGLV6-57

5.90e-05181524f1d88b83a13acd1c8e6b9ff8bd0acaff3650ceef
ToppCell356C-Lymphocytic-Plasma_cell-|356C / Donor, Lineage, Cell class and subclass (all cells)

IGLV2-14 IGLV2-11 IGLV2-8 IGLV6-57

5.90e-0518152470cd612706640d8ebf0e047582b1daa2c1121526
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CFH TLL2 OCA2 SLC4A11

5.90e-051815245f2d3a08577c440c944778d07aa993c6e7873f3d
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-lymphocytic-B_lymphocytic-plasma_cell|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

IGLV2-14 IGLV2-11 IGLV2-8 IGLV6-57

5.90e-05181524f7b08f662eb77ee7a777c6525ddc3195046aaf65
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CFH TLL2 OCA2 SLC4A11

5.90e-05181524c7c5f7d4c397b4613c772413a0a679377efffff3
ToppCellfacs-Lung-nan-3m-Mesenchymal-fibroblast_of_lung|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFH KCNS3 PEAK1 SVEP1

6.03e-05182524c557de6ccd327c46e0a5423cd9936d78e0abae5f
ToppCell3'-GW_trimst-1.5-LargeIntestine-Neuronal-Glial_immature|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MYCL PCSK5 NRXN1 KLHL13

6.03e-05182524ecb5624c9074cc6449fad961df54c926c2681d54
ToppCellfacs-Lung-nan-3m-Mesenchymal-Alveolar_Fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFH KCNS3 PEAK1 SVEP1

6.03e-05182524dbe4b2557cf19e0682ed446f8397d3a1153642f0
ToppCell10x5'-Lung-Lymphocytic_B|Lung / Manually curated celltypes from each tissue

IGLV2-14 IGLV2-11 IGLV2-8 MICAL3

6.03e-05182524310f94437d197eaaaf6e30e68063b33e94befe77
ToppCellcellseq-Immune-Lymphocytic_B-Lymphocytic_B-Plasma|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

IGLV2-14 IGLV2-11 IGLV2-8 IGLV6-57

6.16e-051835245ab4aa0304b832f98fff89b6c24ad5b7dd014c11
ToppCellControl-Lymphocyte-B-B_memory|Control / Disease, Lineage and Cell Type

IGLV2-14 IGLV2-11 IGLV2-8 IGLV6-57

6.16e-05183524491fa04a1d2caeeec6c6403c9a38b4a1257fc2bc
ToppCellP28-Mesenchymal-mesenchymal_fibroblast-alveolar_fibroblast_Wnt2-pa|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

CFH ETV1 KCNS3 SVEP1

6.29e-05184524924400f47e6b2cdf7b0d538df75857935cf0209b
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SUSD4 KLHL13 TLR5 ETV1

6.29e-05184524d33de57876817050b294f2ecb0a4eb0634cfa7f0
ToppCell367C-Lymphocytic-Plasma_cell-|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

IGLV2-14 IGLV2-11 IGLV2-8 IGLV6-57

6.29e-0518452414a5288d861260f63fbe0cbea3569cf643e7597e
ToppCellURO-Myeloid-pDC|URO / Disease, Lineage and Cell Type

LGMN KLHL13 TRAV38-2DV8 PAIP1

6.29e-051845240edb5dd003c2bca0b9e3ec18d03610d68bd52538
ToppCell367C-Lymphocytic-Plasma_cell|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

IGLV2-14 IGLV2-11 IGLV2-8 IGLV6-57

6.29e-05184524fc708a5c8a7b19fab973c72dc4383a7d30f8b59a
ToppCellfacs-Mammary_Gland-Mammary_Gland-3m-Mesenchymal-stromal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFH SSC5D IL18 SVEP1

6.42e-051855243cd0686a14e734a0f243070ab939adcb4c454478
ToppCellfacs-Mammary_Gland-Mammary_Gland-3m-Mesenchymal-stromal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFH SSC5D IL18 SVEP1

6.42e-0518552400258f458cbf6d36449db95528a6b5038d731d2d
ToppCellfacs-Mammary_Gland-Mammary_Gland-3m-Mesenchymal|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFH SSC5D IL18 SVEP1

6.42e-05185524a94694e226856bc5b168464f52d76004145717a5
ToppCell10x_3'_v2v3-Non-neoplastic-Lymphoid-Plasma_B-Plasma_B-Z|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

IGLV2-14 IGLV2-11 IGLV2-8 IGLV6-57

6.42e-0518552496423bdcf0e85ca41370f79347d27c22f3de98f5
ToppCellAdult-Mesenchymal-matrix_fibroblast_2_cell-D231|Adult / Lineage, Cell type, age group and donor

CFH SSC5D KLHL13 SVEP1

6.42e-05185524fb6bd7e849ecf4ed9cd9c4e2a946a2d12d62f804
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CFH TLL2 OCA2 SLC4A11

6.42e-0518552434fcfd635c828dad9643bbf1c908d79282d6f5d9
ToppCell5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_B-plasma_cell-Plasma_cells|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IGLV2-14 IGLV2-11 IGLV2-8 IGLV6-57

6.42e-0518552408bc817908076734d66f2805cb954141f2cc5a18
ToppCell5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_B-plasma_cell|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IGLV2-14 IGLV2-11 IGLV2-8 IGLV6-57

6.42e-051855241704a12153a9b107bf03ecccd1a036cf61334d7a
ComputationalNeighborhood of ITGAL

BTN3A3 SIGIRR BTN3A2 BTN3A1

2.25e-0555334GNF2_ITGAL
ComputationalNeighborhood of CASP8

BTN3A3 BTN3A2 BTN3A1

7.33e-0527333GNF2_CASP8
ComputationalNeighborhood of SNRK

BTN3A3 BTN3A2 BTN3A1

8.20e-0528333GNF2_SNRK
ComputationalNeighborhood of IGFBP1

CFH TDO2 CFHR4

6.89e-0457333CAR_IGFBP1
DrugTrimethylcolchicinic acid [3482-37-9]; Up 200; 11.6uM; PC3; HT_HG-U133A

EPHB2 MYCL NRXN1 ETV1 APC KCNS3 TDO2

1.97e-072004874202_UP
Drug5194442; Up 200; 20uM; PC3; HT_HG-U133A

EPHB2 MYCL BTN3A3 APC MICAL3 BTN3A2

3.42e-061964866594_UP
Drug2-(oxalylamino)benzoic acid

EPHB2 PCSK5 TLR5 ETV1

3.72e-0589484CID000444764
DrugAmiodarone hydrochloride [19774-82-4]; Down 200; 5.8uM; PC3; HT_HG-U133A

MYCL LIG4 ETV1 BTN3A2 BTN3A1

5.42e-051944854657_DN
Drug3-Acetylcoumarin [3949-36-8]; Down 200; 21.2uM; PC3; HT_HG-U133A

EPHB2 ETV1 OCA2 CERT1 BTN3A2

5.56e-051954854664_DN
DrugLoperamide hydrochloride [34552-83-5]; Up 200; 7.8uM; HL60; HG-U133A

EPHB2 APC BTN3A2 BTN3A1 RABGGTB

5.70e-051964852033_UP
DrugGossypol [303-45-7]; Down 200; 7.8uM; PC3; HT_HG-U133A

EPHB2 BTN3A3 APC BTN3A2 SVEP1

5.70e-051964854296_DN
DrugPheniramine maleate [132-20-7]; Up 200; 11.2uM; PC3; HT_HG-U133A

MYCL CFH ETV1 BTN3A2 SVEP1

5.83e-051974854012_UP
DrugTriprolidine hydrochloride [550-70-9]; Down 200; 12.8uM; HL60; HT_HG-U133A

EPHB2 LIG4 IL18 SIGIRR APC

5.83e-051974852376_DN
DrugBethanechol chloride [590-63-6]; Down 200; 20.4uM; PC3; HT_HG-U133A

EPHB2 BTN3A3 ETV1 APC EPHA4

5.83e-051974855114_DN
DrugTenoxicam [59804-37-4]; Down 200; 11.8uM; PC3; HT_HG-U133A

EPHB2 ABR ETV1 APC SVEP1

5.83e-051974854102_DN
DrugSTOCK1N-28457; Down 200; 20uM; PC3; HT_HG-U133A

EPHB2 ABR ETV1 BTN3A2 EPHA4

5.98e-051984856864_DN
DrugPyrimethamine [58-14-0]; Down 200; 16uM; PC3; HT_HG-U133A

EPHB2 HOXA6 BTN3A3 ETV1 BTN3A2

5.98e-051984854194_DN
DrugN-Ac-Tyr-Val-Ala-Asp-chloromethyl ketone

LGMN IL18 APC

5.98e-0536483CID000003722
Diseaseperinatal necrotizing enterocolitis (biomarker_via_orthology)

IL18 TLR5 MUC2

2.37e-0617463DOID:8677 (biomarker_via_orthology)
Diseasec3d:C3 ratio

CFH CFHR4

2.38e-062462EFO_0008543
Diseasecalnexin measurement

CFH CFHR4

7.13e-063462EFO_0801444
Diseasecomplement factor H-related protein 4A measurement

CFH CFHR4

7.13e-063462EFO_0600057
Diseasehistone-lysine N-methyltransferase 2D measurement

CFH CFHR4

7.13e-063462EFO_0801683
DiseaseNADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial measurement

CFH CFHR4

1.42e-054462EFO_0803292
Diseasekallikrein-5 measurement

CFH CFHR4

1.42e-054462EFO_0020515
Diseasecomplement C1s subcomponent measurement

CFH CFHR4

3.55e-056462EFO_0008091
DiseaseMalignant neoplasm of prostate

EPHB2 MYCL IL18 ABR TLR5 ETV1 APC

4.41e-05616467C0376358
DiseaseRectal Neoplasms

APC MUC2

4.97e-057462C0034885
DiseaseRectal Carcinoma

APC MUC2

4.97e-057462C0007113
DiseaseTakayasu arteritis

PCSK5 EHMT2 TLL2 SVEP1

8.42e-05148464EFO_1001857
DiseaseAtypical hemolytic-uremic syndrome

CFH CFHR4

8.50e-059462cv:C2931788
Diseasebeta-mannosidase measurement

CFH LGMN

8.50e-059462EFO_0801421
DiseaseHemolytic-uremic syndrome

CFH CFHR4

8.50e-059462cv:C0019061
Diseaseleukocyte immunoglobulin-like receptor subfamily A member 5 measurement

CFH CFHR4

8.50e-059462EFO_0801766
Diseasecystic fibrosis (is_marker_for)

IL18 TLR5 MUC2

1.26e-0462463DOID:1485 (is_marker_for)
Diseasehemopexin measurement

CFH CFHR4

1.30e-0411462EFO_0008149
Diseasecomplement factor H-related protein 3 measurement

CFH SSC5D EPHA4 CFHR4

1.40e-04169464EFO_0600056
DiseaseIntestinal Neoplasms

APC MUC2

1.55e-0412462C0021841
DiseaseIntestinal Cancer

APC MUC2

1.55e-0412462C0346627
Diseasegallbladder cancer (is_implicated_in)

APC AXIN2

1.83e-0413462DOID:3121 (is_implicated_in)
Diseaseanemia (implicated_via_orthology)

APC SLC4A11

2.46e-0415462DOID:2355 (implicated_via_orthology)
Diseasetumor necrosis factor beta measurement

EPHB2 EHMT2

2.46e-0415462EFO_0008308
Diseasecolorectal health

LIG4 DSG1 KCNS3 EPHA4

2.73e-04201464EFO_0008460
DiseaseBenign neoplasm of stomach

APC AXIN2

3.19e-0417462C0153943
DiseaseNeoplasm of uncertain or unknown behavior of stomach

APC AXIN2

3.19e-0417462C0496905
DiseaseCarcinoma in situ of stomach

APC AXIN2

3.19e-0417462C0154060
Diseaseischemia (biomarker_via_orthology)

IL18 MUC2

3.58e-0418462DOID:326 (biomarker_via_orthology)
DiseaseCarcinoma of bladder

PEAK1 EPHA4

3.58e-0418462C0699885
DiseaseProstatic Neoplasms

MYCL IL18 ABR TLR5 ETV1 APC

3.72e-04616466C0033578
Diseaseurate measurement, bone density

EHMT2 ETV1 KCNS3 TDO2 PEAK1 SLC4A11

3.82e-04619466EFO_0003923, EFO_0004531
Diseasemaximal midexpiratory flow rate

MICAL3 OCA2

4.44e-0420462EFO_0004313
Diseasecoagulation factor measurement

CFH CFHR4

4.44e-0420462EFO_0004634
DiseaseStomach Carcinoma

APC AXIN2

4.90e-0421462C0699791
Diseasechronic hepatitis B virus infection

EHMT2 ETV1

6.42e-0424462EFO_0004239
DiseaseSjogren's syndrome (is_marker_for)

IL18 MUC19

6.42e-0424462DOID:12894 (is_marker_for)
DiseaseColorectal cancer

APC AXIN2

8.14e-0427462cv:C0346629
DiseaseCOLORECTAL CANCER

APC AXIN2

8.14e-0427462114500
DiseaseNeoplasm of the large intestine

APC AXIN2

8.14e-0427462cv:C0009404
Diseasecolorectal cancer (is_implicated_in)

LIG4 APC AXIN2

8.98e-04121463DOID:9256 (is_implicated_in)
Diseasecomplement factor H-related protein 2 measurement

CFH CFHR4

9.40e-0429462EFO_0600055
DiseaseAge related macular degeneration

CFH CFHR4

1.01e-0330462C0242383
DiseaseComplement deficiency disease

CFH CFHR4

1.22e-0333462C0272242
DiseaseInflammatory Bowel Diseases

MUC19 APC

1.37e-0335462C0021390
Diseasehair color

ETV1 OCA2 AXIN2 EPHA4

1.39e-03311464EFO_0003924
DiseaseAdenoma, Microcystic

APC MUC2

1.45e-0336462C0205648
DiseaseAdenoma, Monomorphic

APC MUC2

1.45e-0336462C0205649
DiseaseAdenoma, Basal Cell

APC MUC2

1.45e-0336462C0205646
DiseaseFollicular adenoma

APC MUC2

1.45e-0336462C0205647
DiseasePapillary adenoma

APC MUC2

1.45e-0336462C0205650
DiseaseAdenoma, Trabecular

APC MUC2

1.45e-0336462C0205651
DiseaseAdenoma

APC MUC2

1.45e-0336462C0001430
Diseasehuman immunodeficiency virus infectious disease (is_marker_for)

EPHB2 IL18

1.45e-0336462DOID:526 (is_marker_for)

Protein segments in the cluster

PeptideGeneStartEntry
DTLYSNFSYGTDEYD

ABR

16

Q12979
SGKYLCYFQDGDFYE

BTN3A3

121

O00478
SGKYLCYFQDGDFYE

BTN3A1

121

O00481
VYSLEAYSCASKYAF

EXOC1L

96

A0A1B0GW35
YRYYFKKASDEFACG

AXIN2

801

Q9Y2T1
VGDDFSLYYDSYSVD

EHMT2

266

Q96KQ7
SDSYQYGEEVTYKCF

CFH

946

P08603
FSETGFFDYCAVKAY

OCA2

401

Q04671
ALSYYKSEDETEYGC

CERT1

51

Q9Y5P4
SAYAYDIEDGKFYCK

MICAL3

801

Q7RTP6
SYEYGASCFYSDKDL

HOXA6

71

P31267
GTCKETFNLYYYESD

EPHA4

116

P54764
KTEDEADYYCQSYDS

IGLV6-57

101

P01721
SCKETFNLYYYEADF

EPHB2

106

P29323
SYYFDHSSENGYKSC

PCSK5

821

Q92824
TFDGKSYSFDGLCQY

MUC19

1286

Q7Z5P9
YNFASDCRGSYKEFA

MUC2

61

Q02817
CEAGDAVYYTASYAK

PEAK1

1336

Q9H792
FSYGEKCLYNVSAYD

ETV1

111

P50549
AEDEADYYCSLYTSS

IGLV2-18

101

A0A075B6J9
LCDDYSVADKEYYFD

KCNS3

56

Q9BQ31
EYIATFKGSEYFCYD

NRXN1

281

Q9ULB1
YFTVTCYSGYGDDEK

DNAJC21

91

Q5F1R6
SYFCQKAYAYADEDE

DSG1

696

Q02413
QEACDSYKSGYVYSE

MILR1

326

Q7Z6M3
SSSYTESYEDGCEDY

PAIP1

141

Q9H074
YIASYGSKKDDYEYC

RABGGTB

26

P53611
VSASVYAKYYFDLCA

CCNYL3

171

P0C7X3
GEDSGIYSCVYYLDS

IGSF1

1126

Q8N6C5
RGTSDYDDVLSCEYY

KLHL13

546

Q9P2N7
REYDCYGDSYFIDTD

LIG4

756

P49917
KYSASYDSYSESSGY

CEP350

1521

Q5VT06
SGKYLCYFQDGDFYE

BTN3A2

121

P78410
TLDYECYDGYESSYG

CFHR4

171

Q92496
FESSSYEGYFLACEK

IL18

151

Q14116
AEDEADYYCCSYAGS

IGLV2-11

101

P01706
AEDEADYYCSSYTSS

IGLV2-14

101

P01704
SQNGYFEDSSYYKCD

SLC4A11

21

Q8NBS3
HKFLYTAEYCDSSYF

TDO2

386

P48775
AEDEADYYCSSYAGS

IGLV2-8

101

P01709
KFYATSYCTAYGRED

PPP1R32

26

Q7Z5V6
DGKLYDAYVSYSDCP

SIGIRR

161

Q6IA17
DVGLTCTGYTDYDDY

SSC5D

866

A1L4H1
GYDFTEGSTDKYYCA

SVEP1

756

Q4LDE5
DIAFYYCSDGYSLAD

SVEP1

2041

Q4LDE5
YSEDDESKFCSYGQY

APC

986

P25054
YDYDCGEDFYRSTAP

MYCL

11

P12524
LSCTYDTSESDYYLF

TRA

41

P0DTU3
EFYCDPGYSLTSDYK

SUSD4

271

Q5VX71
CGYDYMEAYDGYDSS

TLL2

946

Q9Y6L7
CDSDGAQDYYSDYAY

ZNF598

216

Q86UK7
KFKYAQEYDSGTYRC

TMEM81

146

Q6P7N7
LSCTYDTSESDYYLF

TRAV38-2DV8

41

A0JD32
YKYDAYLCFSSKDFT

TLR5

691

O60602
SYACYYDEKRSTYLG

LGMN

216

Q99538