Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	nucleoside-triphosphatase regulator activity	RAPGEF6 RASA1 MYO9A DOCK8 ITSN1 LRRK2 SRGAP2 DENND4C CCDC88C TBC1D4 ARHGEF10 ARHGEF1 RASGEF1B RAPGEF2 ARAP2 MTSS2	1.05e-05	507	175	16	GO:0060589
GeneOntologyMolecularFunction	GTPase regulator activity	RAPGEF6 RASA1 MYO9A DOCK8 ITSN1 LRRK2 SRGAP2 DENND4C CCDC88C TBC1D4 ARHGEF10 ARHGEF1 RASGEF1B RAPGEF2 ARAP2 MTSS2	1.05e-05	507	175	16	GO:0030695
GeneOntologyMolecularFunction	guanyl-nucleotide exchange factor activity	RAPGEF6 DOCK8 ITSN1 DENND4C CCDC88C ARHGEF10 ARHGEF1 RASGEF1B RAPGEF2	2.08e-04	231	175	9	GO:0005085
GeneOntologyBiologicalProcess	negative regulation of defense response to bacterium	ARG2 MAPKBP1 SPINK5	1.16e-05	6	174	3	GO:1900425
Domain	Cnn_1N	PDE4DIP CDK5RAP2	2.51e-04	3	172	2	IPR012943
Domain	srGAP2	SRGAP2 SRGAP2B	2.51e-04	3	172	2	IPR030252
Domain	Cnn_1N	PDE4DIP CDK5RAP2	2.51e-04	3	172	2	PF07989
Domain	RA	RAPGEF6 MYO9A RAPGEF2 ARAP2	3.25e-04	36	172	4	PF00788
Domain	RA	RAPGEF6 MYO9A RAPGEF2 ARAP2	3.62e-04	37	172	4	PS50200
Domain	RA_dom	RAPGEF6 MYO9A RAPGEF2 ARAP2	4.90e-04	40	172	4	IPR000159
Domain	TEA_1	TEAD2 TEAD1	5.00e-04	4	172	2	PS00554
Domain	TEA_2	TEAD2 TEAD1	5.00e-04	4	172	2	PS51088
Domain	G8_domain	PKHD1L1 CEMIP	5.00e-04	4	172	2	IPR019316
Domain	TEA	TEAD2 TEAD1	5.00e-04	4	172	2	PF01285
Domain	TEA/ATTS_dom	TEAD2 TEAD1	5.00e-04	4	172	2	IPR000818
Domain	TEF_metazoa	TEAD2 TEAD1	5.00e-04	4	172	2	IPR016361
Domain	G8	PKHD1L1 CEMIP	5.00e-04	4	172	2	PS51484
Domain	G8	PKHD1L1 CEMIP	5.00e-04	4	172	2	SM01225
Domain	TEA	TEAD2 TEAD1	5.00e-04	4	172	2	SM00426
Domain	G8	PKHD1L1 CEMIP	5.00e-04	4	172	2	PF10162
Pubmed	Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.	RPL28 EPPK1 AFF2 MYO9A LAMA1 LRRK2 MYO18A RNF213 HELQ PRDM2 CCDC88C TBC1D4 CDK5RAP2	6.22e-11	208	177	13	33230847
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	RAPGEF6 MYO9A ZNF629 SRGAP2 VIRMA DENND4C CCDC88C KSR1 ZNF106 ESYT2 TBC1D4 MDN1 ARHGEF10 IKBKE ARHGEF1 OSBPL6 FAM83G RAPGEF2 ARAP2 MTSS2 TPD52L1 CCSER1	6.17e-10	861	177	22	36931259
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	RAPGEF6 ITSN1 POLR2A MYO18A ISL2 HUWE1 POLA2 VIRMA PRDM2 PITPNM1 ZNF106 MYOF ESYT2 TBC1D4 MDN1 USP42 MKI67 OTUD4 PRKDC	1.87e-08	774	177	19	15302935
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	SETMAR ACO1 ITSN1 SPTB ZNF189 DYNC2I1 SRGAP2 HUWE1 CBR1 BHLHE40 ARG2 STX1A HEATR6 TTC7B ZNF660 ARHGEF10 PDE4DIP MAST1 PRKDC JAKMIP1 RAPGEF2 DYNC1H1 RNF111	1.79e-07	1285	177	23	35914814
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	ENGASE TEAD2 FRAS1 RAPGEF6 EPPK1 PCNX3 POLR2A SRGAP2 HUWE1 ZZEF1 CCDC88C MYOF MDN1 MTMR14 IER5L NFKB2 PRKDC MAPKBP1 ZNF426 DYNC1H1 ABCC10	2.43e-07	1105	177	21	35748872
Pubmed	Conditional deletion of activating protein 2alpha (AP-2alpha) in the developing retina demonstrates non-cell-autonomous roles for AP-2alpha in optic cup development.	ISL2 ISL1 STX1A MKI67	4.47e-07	13	177	4	17724084
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	RAPGEF6 DOCK8 SRGAP2 TEAD1 DENND4C CCDC88C KSR1 TBC1D4 ACAD11 PRKDC RAPGEF2 TPD52L1 NIN	5.44e-07	446	177	13	24255178
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	USP36 POLR2A ZNF629 MCC RNF213 WDR37 ZZEF1 DNTTIP2 ARG2 KSR1 TADA1 ACAD11 PRPF4 LTN1 ADAM17 OSMR RAPGEF2 CLSPN ARAP2 NIN	1.19e-06	1116	177	20	31753913
Pubmed	Distinct timing of neurogenesis of ipsilateral and contralateral retinal ganglion cells.	ISL2 ISL1 MKI67	1.29e-06	5	177	3	29761490
Pubmed	RAG-2 deficiency results in fewer phosphorylated histone H2AX foci, but increased retinal ganglion cell death and altered axonal growth.	ISL2 ISL1 PRKDC	2.56e-06	6	177	3	31811168
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	USP36 RPL28 AFF2 CCDC186 LRRK2 RNF213 HUWE1 PKHD1L1 MKI67 CDK5RAP2 PRKDC RAPGEF2 CLSPN SCLT1 DYNC1H1 ARAP2	2.59e-06	777	177	16	35844135
Pubmed	A systems-wide screen identifies substrates of the SCFβTrCP ubiquitin ligase.	DYNC2I1 HUWE1 BHLHE40 DENND4C TBC1D4 NFKB2 RAPGEF2 CLSPN DYNC1H1	3.24e-06	232	177	9	25515538
Pubmed	Identification of 14-3-3epsilon substrates from embryonic murine brain.	CACNB1 DOCK8 SRGAP2 WDR37 CBR1 KSR1 TBC1D4	5.42e-06	132	177	7	16944949
Pubmed	Mouse screen reveals multiple new genes underlying mouse and human hearing loss.	SETMAR MYO9A ISG20 TRIM29 WDR37 BHLHE40 VIRMA KIF24 DENND4C PITPNM1 ZNF106 FARSA MDN1 USP42 ARHGEF1 CDK5RAP2 ADAM17 MST1L ARAP2 MTSS2	5.90e-06	1242	177	20	30973865
Pubmed	Comprehensive proteomic analysis of interphase and mitotic 14-3-3-binding proteins.	CBLL1 SPTB SRGAP2 VIRMA TBC1D4 PRKDC RAPGEF2 DYNC1H1	6.34e-06	190	177	8	15161933
Pubmed	Overlapping functions of SIX homeoproteins during embryonic myogenesis.	MYH7 ISL2 ISL1 MKI67	6.36e-06	24	177	4	37267426
Pubmed	Overlapping expression patterns and redundant roles for AP-2 transcription factors in the developing mammalian retina.	ISL2 ISL1 STX1A MKI67	7.54e-06	25	177	4	22411557
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	CBLL1 CACNB1 ITSN1 MCC SRGAP2 HUWE1 VIRMA CCDC88C FARSA MDN1 PDE4DIP OTUD4 CDK5RAP2 JAKMIP1 RAPGEF2 DYNC1H1 MTSS2	9.54e-06	963	177	17	28671696
Pubmed	TRPV2 enhances axon outgrowth through its activation by membrane stretch in developing sensory and motor neurons.	ISL2 ISL1 MKI67	1.06e-05	9	177	3	20357111
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	RPL28 MYO9A DOCK8 ITSN1 SPTB MYO18A SRGAP2 MTHFS WDR37 CBR1 VIRMA PITPNM1 FARSA TTC7B ARHGEF1 PDE4DIP OSBPL6 OTUD4 MAST1 RAPGEF2 DYNC1H1	1.39e-05	1431	177	21	37142655
Pubmed	Dependence of leucine-rich repeat kinase 2 (LRRK2) kinase activity on dimerization.	LRRK2 PRKDC DYNC1H1	1.51e-05	10	177	3	19826009
Pubmed	MicroRNA-132 is enriched in developing axons, locally regulates Rasa1 mRNA, and promotes axon extension.	RASA1 ISL2 ISL1	1.51e-05	10	177	3	24381269
Pubmed	SoxC Transcription Factors Promote Contralateral Retinal Ganglion Cell Differentiation and Axon Guidance in the Mouse Visual System.	ISL2 ISL1 MKI67	1.51e-05	10	177	3	28215559
Pubmed	Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	ZNF629 HUWE1 MDN1 ARHGEF10 RAPGEF2 DYNC1H1	1.60e-05	104	177	6	9205841
Pubmed	A Disintegrin and Metalloproteinase10 (ADAM10) Regulates NOTCH Signaling during Early Retinal Development.	ISL2 ISL1 ADAM17	2.08e-05	11	177	3	27224017
Pubmed	Temporally restricted death and the role of p75NTR as a survival receptor in the developing sensory nervous system.	ISL2 ISL1 MKI67	2.08e-05	11	177	3	29569362
Pubmed	IΚΚε cooperates with either MEK or non-canonical NF-kB driving growth of triple-negative breast cancer cells in different contexts.	IKBKE NFKB2	2.58e-05	2	177	2	29801480
Pubmed	The PDZ domain of the guanine nucleotide exchange factor PDZGEF directs binding to phosphatidic acid during brush border formation.	RAPGEF6 RAPGEF2	2.58e-05	2	177	2	24858808
Pubmed	Testis-enriched kinesin KIF9 is important for progressive motility in mouse spermatozoa.	KIF9 HYDIN	2.58e-05	2	177	2	32072696
Pubmed	CSF lamp2 concentrations are decreased in female Parkinson's disease patients with LRRK2 mutations.	LRRK2 LAMP2	2.58e-05	2	177	2	29456132
Pubmed	Transcriptional enhancer factor-1 in cardiac myocytes interacts with an alpha 1-adrenergic- and beta-protein kinase C-inducible element in the rat beta-myosin heavy chain promoter.	MYH7 TEAD1	2.58e-05	2	177	2	8253797
Pubmed	Association study of FLT4 and HYDIN single nucleotide polymorphisms with atrial septal defect susceptibility in the Han Chinese population of Southwest China.	FLT4 HYDIN	2.58e-05	2	177	2	38581027
Pubmed	A conditional null allele of Dync1h1 enables targeted analyses of dynein roles in neuronal length sensing.	ISL1 DYNC1H1	2.58e-05	2	177	2	36218033
Pubmed	Requirement for SNAPC1 in transcriptional responsiveness to diverse extracellular signals.	POLR2A SNAPC1	2.58e-05	2	177	2	22966203
Pubmed	Phosphatidic acid-dependent localization and basal de-phosphorylation of RA-GEFs regulate lymphocyte trafficking.	RAPGEF6 RAPGEF2	2.58e-05	2	177	2	32600317
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	ITSN1 POLR2A BCORL1 LAMA1 RNF213 HUWE1 ZZEF1 QRICH2 PRDM2 TBC1D4 MDN1 PRKDC JAKMIP1 DYNC1H1	2.69e-05	736	177	14	29676528
Pubmed	Netrin1/DCC signaling promotes neuronal migration in the dorsal spinal cord.	ISL2 ISL1 MKI67	2.76e-05	12	177	3	27784329
Pubmed	∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis.	RPL28 MYH7 EPPK1 MYO18A HUWE1 TRIM29 CBR1 ESYT2 MDN1 LTN1 ADAM17 PRKDC DYNC1H1	3.00e-05	647	177	13	26618866
Pubmed	Expression pattern of transcriptional enhanced associate domain family member 1 (Tead1) in developing mouse molar tooth.	TEAD2 TEAD1 MKI67	3.57e-05	13	177	3	33984529
Pubmed	Defective postnatal neurogenesis and disorganization of the rostral migratory stream in absence of the Vax1 homeobox gene.	ISL2 ISL1 MKI67	3.57e-05	13	177	3	15590934
Pubmed	Prdx4 is a compartment-specific H2O2 sensor that regulates neurogenesis by controlling surface expression of GDE2.	ISL2 ISL1 MKI67	3.57e-05	13	177	3	25943695
Pubmed	The antioxidant enzyme Prdx1 controls neuronal differentiation by thiol-redox-dependent activation of GDE2.	ISL2 ISL1 MKI67	3.57e-05	13	177	3	19766572
Pubmed	Cep120 and TACCs control interkinetic nuclear migration and the neural progenitor pool.	PDE4DIP CDK5RAP2 NIN	3.57e-05	13	177	3	17920017
Pubmed	Neurogenin2 identifies a transplantable dopamine neuron precursor in the developing ventral mesencephalon.	ISL2 ISL1 MKI67	3.57e-05	13	177	3	16438966
Pubmed	A Second Heart Field-Derived Vasculogenic Niche Contributes to Cardiac Lymphatics.	FLT4 POLR2A ISL1	3.57e-05	13	177	3	31928974
Pubmed	Destabilization of Atoh1 by E3 Ubiquitin Ligase Huwe1 and Casein Kinase 1 Is Essential for Normal Sensory Hair Cell Development.	RNF213 HUWE1 MDN1 PRKDC DYNC1H1	4.45e-05	76	177	5	27542412
Pubmed	Cux2 (Cutl2) integrates neural progenitor development with cell-cycle progression during spinal cord neurogenesis.	ISL2 ISL1 MKI67	4.53e-05	14	177	3	18223201
Pubmed	p190RhoGAP Filters Competing Signals to Resolve Axon Guidance Conflicts.	RASA1 ISL2 ISL1	4.53e-05	14	177	3	30902550
Pubmed	Pituitary adenylyl cyclase-activating peptide counteracts hedgehog-dependent motor neuron production in mouse embryonic stem cell cultures.	ISL2 ISL1 MKI67	4.53e-05	14	177	3	21674568
Pubmed	A novel view of the transcriptome revealed from gene trapping in mouse embryonic stem cells.	ITSN1 SRGAP2 RNF111 SEC14L1	5.14e-05	40	177	4	17540781
Pubmed	Substrate trapping proteomics reveals targets of the βTrCP2/FBXW11 ubiquitin ligase.	DENND4C TBC1D4 NFKB2 RAPGEF2 CLSPN MTSS2	5.18e-05	128	177	6	25332235
Pubmed	Functional proteomics mapping of a human signaling pathway.	RPL28 FLT4 THSD7A DOCK8 ITSN1 HUWE1 TRIM29 ZZEF1 ZNF106 PDE4DIP DYNC1H1 RNF111	5.52e-05	591	177	12	15231748
Pubmed	Determination of retinal cell fates is affected in the absence of extraocular striated muscles.	ISL2 ISL1 STX1A	5.64e-05	15	177	3	12619134
Pubmed	IKAP localizes to membrane ruffles with filamin A and regulates actin cytoskeleton organization and cell migration.	ELP2 PRKDC DYNC1H1	5.64e-05	15	177	3	18303054
Pubmed	Identification of potential protein interactors of Lrrk2.	LRRK2 MDN1 PRKDC	5.64e-05	15	177	3	17400507
Pubmed	FBW7 suppresses ovarian cancer development by targeting the N6-methyladenosine binding protein YTHDF2.	RPL28 POLR2A MYO18A RNF213 WDR37 ARHGEF10 ARHGEF1 NFKB2 OTUD4 UHRF1 PRKDC DYNC1H1	6.48e-05	601	177	12	33658012
Pubmed	NOVA regulates Dcc alternative splicing during neuronal migration and axon guidance in the spinal cord.	ISL2 ISL1 MKI67	6.91e-05	16	177	3	27223328
Pubmed	Nf2-Yap signaling controls the expansion of DRG progenitors and glia during DRG development.	ISL2 ISL1 MKI67	6.91e-05	16	177	3	25433207
Pubmed	Foxp-mediated suppression of N-cadherin regulates neuroepithelial character and progenitor maintenance in the CNS.	ISL2 ISL1 MKI67	6.91e-05	16	177	3	22542185
Pubmed	Dynamic expression of the Onecut transcription factors HNF-6, OC-2 and OC-3 during spinal motor neuron development.	ISL2 ISL1 MKI67	6.91e-05	16	177	3	19800948
Pubmed	Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.	PIK3AP1 ANO2 CACNB1 ACO1 ZNF385D EYS JAKMIP1	7.62e-05	199	177	7	23382691
Pubmed	Inhibition of SRGAP2 function by its human-specific paralogs induces neoteny during spine maturation.	SRGAP2 SRGAP2B	7.70e-05	3	177	2	22559944
Pubmed	Differential Islet-1 expression among lumbosacral spinal motor neurons in prenatal mouse.	ISL2 ISL1	7.70e-05	3	177	2	19236857
Pubmed	A new Prdm1-Cre line is suitable for studying the second heart field development.	ISL1 MKI67	7.70e-05	3	177	2	38880275
Pubmed	Initial trajectories of sensory axons toward laminar targets in the developing mouse spinal cord.	ISL2 ISL1	7.70e-05	3	177	2	9100133
Pubmed	Activated Alk triggers prolonged neurogenesis and Ret upregulation providing a therapeutic target in ALK-mutated neuroblastoma.	ISL1 MKI67	7.70e-05	3	177	2	24811913
Pubmed	ECEL1 mutation implicates impaired axonal arborization of motor nerves in the pathogenesis of distal arthrogryposis.	ISL2 ISL1	7.70e-05	3	177	2	26951213
Pubmed	Host B7-H4 regulates antitumor T cell responses through inhibition of myeloid-derived suppressor cells in a 4T1 tumor transplantation model.	VTCN1 PRKDC	7.70e-05	3	177	2	23686485
Pubmed	Islet-1 expression in thoracic spinal motor neurons in prenatal mouse.	ISL2 ISL1	7.70e-05	3	177	2	21651972
Pubmed	STRA13 interacts with STAT3 and modulates transcription of STAT3-dependent targets.	BHLHE40 ELP2	7.70e-05	3	177	2	15223310
Pubmed	Emergence of sigh rhythmogenesis in the embryonic mouse.	ISL2 ISL1	7.70e-05	3	177	2	24591570
Pubmed	Glycine release from radial cells modulates the spontaneous activity and its propagation during early spinal cord development.	ISL2 ISL1	7.70e-05	3	177	2	20053920
Pubmed	Comprehensive behavioral analysis of mice deficient in Rapgef2 and Rapgef6, a subfamily of guanine nucleotide exchange factors for Rap small GTPases possessing the Ras/Rap-associating domain.	RAPGEF6 RAPGEF2	7.70e-05	3	177	2	29747665
Pubmed	Functional interaction between the p160 coactivator proteins and the transcriptional enhancer factor family of transcription factors.	TEAD2 TEAD1	7.70e-05	3	177	2	10934189
Pubmed	Cell competition in mouse NIH3T3 embryonic fibroblasts is controlled by the activity of Tead family proteins and Myc.	TEAD2 TEAD1	7.70e-05	3	177	2	25588835
Pubmed	HUWE1-dependent DNA-PKcs neddylation modulates its autophosphorylation in DNA damage response.	HUWE1 PRKDC	7.70e-05	3	177	2	32457294
Pubmed	Expression of sorting nexin 18 (SNX18) is dynamically regulated in developing spinal motor neurons.	ISL2 ISL1	7.70e-05	3	177	2	21339182
Pubmed	IkappaB kinase epsilon interacts with p52 and promotes transactivation via p65.	IKBKE NFKB2	7.70e-05	3	177	2	17003035
Pubmed	Wnt5a and Wnt11 are essential for second heart field progenitor development.	ISL1 BHLHE40 MKI67	8.36e-05	17	177	3	22569553
Pubmed	Role of motoneuron-derived neurotrophin 3 in survival and axonal projection of sensory neurons during neural circuit formation.	ISL2 ISL1 MKI67	8.36e-05	17	177	3	22318233
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	USP36 POLR2A RNF213 HUWE1 ESYT2 TBC1D4 PTPRB TTC7B MTMR14 PRPF4 LTN1 MKI67 OTUD4 CDK5RAP2 ELP2 NIN	9.95e-05	1049	177	16	27880917
Pubmed	Identification of different proteins binding to Na, K-ATPase α1 in LPS-induced ARDS cell model by proteomic analysis.	POLR2A RNF213 MYOF NFKB2 PRKDC DYNC1H1	9.95e-05	144	177	6	35681168
Pubmed	The graded response to Sonic Hedgehog depends on cilia architecture.	ISL2 ISL1 MKI67	1.00e-04	18	177	3	17488627
Pubmed	Generalist genes analysis of DNA markers associated with mathematical ability and disability reveals shared influence across ages and abilities.	FRAS1 SRGAP2 BDKRB2	1.00e-04	18	177	3	20602751
Pubmed	A Cranial Mesoderm Origin for Esophagus Striated Muscles.	MYH7 ISL1 MKI67	1.00e-04	18	177	3	26387456
Pubmed	Disruption of a ciliary B9 protein complex causes Meckel syndrome.	ISL2 ISL1 NIN	1.00e-04	18	177	3	21763481
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	PIK3AP1 ITSN1 POLR2A MCC DYNC2I1 RNF213 SRGAP2 HUWE1 DENND4C ZNF106 FARSA ARHGEF10 CLSPN	1.06e-04	733	177	13	34672954
Pubmed	Cross-Linking Mass Spectrometry Uncovers Interactions Between High-Density Lipoproteins and the SARS-CoV-2 Spike Glycoprotein.	MYH7 MYOF CFAP54 DYNC1H1 SPINK5	1.11e-04	92	177	5	37343697
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	CBLL1 USP36 RPL28 POLR2A BCORL1 ZNF629 TEAD1 BHLHE40 DNTTIP2 PRDM2 ZNF106 ESYT2 MDN1 USP42 PRPF4 MKI67 UHRF1 PRKDC	1.16e-04	1294	177	18	30804502
Pubmed	Asb2α-Filamin A Axis Is Essential for Actin Cytoskeleton Remodeling During Heart Development.	MYH7 ISL1 MKI67	1.18e-04	19	177	3	29374072
Pubmed	m6A regulation of cortical and retinal neurogenesis is mediated by the redundant m6A readers YTHDFs.	ISL2 ISL1 MKI67	1.18e-04	19	177	3	36039295
Pubmed	Oligodendrocyte precursors migrate along vasculature in the developing nervous system.	ISL2 ISL1 MKI67	1.39e-04	20	177	3	26798014
Pubmed	Runx1 expression defines a subpopulation of displaced amacrine cells in the developing mouse retina.	ISL1 STX1A MKI67	1.39e-04	20	177	3	16026391
Pubmed	Overexpression of TEAD-1 in transgenic mouse striated muscles produces a slower skeletal muscle contractile phenotype.	TEAD2 MYH7 TEAD1	1.39e-04	20	177	3	18978355
Pubmed	SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling.	RPL28 ACO1 RNF213 FARSA MTMR14 PDE4DIP OTUD4 PRKDC KRT25 DYNC1H1 CCSER1	1.46e-04	558	177	11	27591049
Pubmed	Evolution of human-specific neural SRGAP2 genes by incomplete segmental duplication.	SRGAP2 SRGAP2B	1.53e-04	4	177	2	22559943
Pubmed	Coordinated changes in cellular behavior ensure the lifelong maintenance of the hippocampal stem cell population.	HUWE1 MKI67	1.53e-04	4	177	2	33581058
Pubmed	The transcription factor EPAS1 links DOCK8 deficiency to atopic skin inflammation via IL-31 induction.	DOCK8 OSMR	1.53e-04	4	177	2	28067314
Pubmed	Nuclear factor κB2 p52 protein has a role in antiviral immunity through IκB kinase epsilon-dependent induction of Sp1 protein and interleukin 15.	IKBKE NFKB2	1.53e-04	4	177	2	23873932
Pubmed	Robo1 and 2 Repellent Receptors Cooperate to Guide Facial Neuron Cell Migration and Axon Projections in the Embryonic Mouse Hindbrain.	ISL2 ISL1	1.53e-04	4	177	2	30685539
Interaction	YWHAG interactions	BNIP5 RAPGEF6 RPS6KA4 MYO9A TNIP2 LRRK2 ZNF629 MCC SRGAP2 HUWE1 WDR37 VIRMA DENND4C DNTTIP2 CCDC88C KSR1 DFFA ZNF106 ESYT2 TBC1D4 MDN1 ARHGEF1 OSBPL6 FAM83G PRKDC JAKMIP1 RAPGEF2 DYNC1H1 ARAP2 MTSS2 TPD52L1 CCSER1	1.95e-08	1248	172	32	int:YWHAG
Interaction	YWHAH interactions	RAPGEF6 EPPK1 RPS6KA4 MYO9A LRRK2 ZNF629 SRGAP2 HUWE1 POLA2 WDR37 VIRMA DENND4C CCDC88C KSR1 ZNF106 ESYT2 TBC1D4 IKBKE OSBPL6 FAM83G MAST1 JAKMIP1 RAPGEF2 ARAP2 MTSS2 TPD52L1 CCSER1 NIN	2.08e-07	1102	172	28	int:YWHAH
Interaction	YWHAZ interactions	CPA6 BNIP5 RAPGEF6 MYO9A LRRK2 MYO18A ZNF629 MCC SRGAP2 HUWE1 WDR37 CBR1 VIRMA DENND4C CCDC88C KSR1 DFFA TBC1D4 OSBPL6 FAM83G OTUD4 MAST1 CDK5RAP2 JAKMIP1 RAPGEF2 DYNC1H1 ARAP2 MTSS2 TPD52L1 CCSER1 NIN	2.36e-07	1319	172	31	int:YWHAZ
Interaction	YWHAQ interactions	CBLL1 MYH7 RAPGEF6 EPPK1 RPS6KA4 MYO9A SPTB LRRK2 ZNF629 SRGAP2 WDR37 VIRMA DENND4C CCDC88C KSR1 ZNF106 TBC1D4 USP42 PRPF4 OSBPL6 FAM83G PRKDC RAPGEF2 DYNC1H1 ARAP2 MTSS2 TPD52L1 CCSER1	2.78e-07	1118	172	28	int:YWHAQ
Interaction	YWHAB interactions	RAPGEF6 RPS6KA4 MYO9A LRRK2 ZNF629 MCC SRGAP2 WDR37 VIRMA DENND4C CCDC88C KSR1 ZNF106 ESYT2 TBC1D4 OSBPL6 FAM83G MAST1 JAKMIP1 RAPGEF2 DYNC1H1 ARAP2 MTSS2 TPD52L1 CCSER1	1.74e-06	1014	172	25	int:YWHAB
Interaction	YWHAE interactions	BNIP5 CACNB1 RAPGEF6 MYO9A DOCK8 TNIP2 LRRK2 ZNF629 MCC SRGAP2 HUWE1 WDR37 CBR1 VIRMA DENND4C CCDC88C KSR1 ZNF106 TBC1D4 OSBPL6 FAM83G MAST1 JAKMIP1 RAPGEF2 DYNC1H1 ARAP2 CCSER1 NIN	2.77e-06	1256	172	28	int:YWHAE
Interaction	DYNC1H1 interactions	USP36 FLT4 EPPK1 ITSN1 LRRK2 HUWE1 MTHFS VIRMA CCDC88C HEATR6 PRKDC SCLT1 HYDIN DYNC1H1 NIN	2.15e-05	491	172	15	int:DYNC1H1
Interaction	KRT8 interactions	RAPGEF6 EPPK1 TNIP2 OVCH1 VIRMA NLN ESYT2 FARSA TBC1D4 LTN1 OTUD4 CDK5RAP2 KRT25 NIN	2.68e-05	441	172	14	int:KRT8
Interaction	BRCA2 interactions	CBLL1 SHLD2 POLR2A LRRK2 HUWE1 TRIM29 HELQ VIRMA F8 MKI67 CLSPN DYNC1H1 NIN	2.70e-05	384	172	13	int:BRCA2
Interaction	DUSP16 interactions	RAPGEF6 TNIP2 SRGAP2 POLA2 VIRMA DENND4C ARHGEF1 CDK5RAP2 HPS5 DYNC1H1	3.80e-05	237	172	10	int:DUSP16
Interaction	JAK1 interactions	LAMP2 TSHR ISL1 VIRMA KIF24 ACAD11 LTN1 ELP2 JAKMIP1 OSMR	5.57e-05	248	172	10	int:JAK1
Interaction	KCNA3 interactions	RPL28 EPPK1 AFF2 MYO9A LAMA1 LRRK2 MYO18A RNF213 LAMP2 THSD1 HELQ DENND4C PRDM2 CCDC88C ESYT2 FARSA TBC1D4 CDK5RAP2 PRKDC DYNC1H1	5.62e-05	871	172	20	int:KCNA3
Interaction	PMS2 interactions	RASA1 ZNF189 TRIM29 PRKDC CLSPN CCDC180	6.31e-05	80	172	6	int:PMS2
Interaction	CTDP1 interactions	POLR2A RNF213 VIRMA ESYT2 HEATR6 MDN1 LTN1 ELP2 PRKDC	7.42e-05	207	172	9	int:CTDP1
GeneFamily	TEA domain transcription factors	TEAD2 TEAD1	2.35e-04	4	114	2	1183
GeneFamily	EF-hand domain containing\|Spectrins	SPTB SPTBN5	8.11e-04	7	114	2	1113
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	RASA1 ITSN1 EXT1 SRGAP2 TEAD1 WDR37 ZZEF1 BHLHE40 CEMIP MYOF MDN1 ATP11B ARHGEF10 LTN1 OTUD4 ADAM17 OSMR RAPGEF2 ARAP2 SEC14L1	1.38e-06	856	176	20	M4500
Coexpression	MANNO_MIDBRAIN_NEUROTYPES_HGABA	RAPGEF6 THSD7A AFF2 CCDC186 LRRK2 CHST1 PRDM2 CEMIP ZNF385D NLN MDN1 PDE4DIP RASGEF1B OSBPL6 ZNF816 OTUD4 MAST1 GOLGA7B HYDIN FRMD3 TPD52L1 CCSER1	5.43e-06	1106	176	22	M39071
Coexpression	ZAK_PBMC_MRKAD5_HIV_1_GAG_POL_NEF_AGE_20_50YO_1DY_UP	PIK3AP1 ATP8B4 RNF19B LRRK2 RNF213 LAMP2 EXT1 SRGAP2 ISG20 CBR1 KSR1 MYOF NLN RASGEF1B ADAM17 SRGAP2B RAPGEF2 SCLT1 FRMD3 SEC14L1	1.64e-05	1012	176	20	M40868
Coexpression	DEBIASI_APOPTOSIS_BY_REOVIRUS_INFECTION_DN	ITSN1 POLR2A SRGAP2 POLA2 CBR1 ARHGEF10 MKI67 ADAM17 ABCC10 SEC14L1	1.86e-05	276	176	10	M3063
Coexpression	GSE18791_UNSTIM_VS_NEWCATSLE_VIRUS_DC_6H_DN	MYH7 SWT1 RNF213 SRGAP2 ISG20 CBR1 USP42 IKBKE	5.44e-05	195	176	8	M4292
Coexpression	GSE20727_CTRL_VS_ROS_INH_AND_DNFB_ALLERGEN_TREATED_DC_UP	ACO1 LRRK2 CCDC88C TADA1 HEATR6 TBC1D4 IKBKE NIN	5.85e-05	197	176	8	M9250
Coexpression	GSE24634_IL4_VS_CTRL_TREATED_NAIVE_CD4_TCELL_DAY5_DN	RPL28 AFF2 ISG20 LCT PRDM2 CCDC88C PTPRB NFKB2	6.28e-05	199	176	8	M4635
Coexpression	GSE36888_STAT5_AB_KNOCKIN_VS_WT_TCELL_IL2_TREATED_6H_UP	PIK3AP1 SCRN3 AFF2 RASA1 POLR2A DYNC2I1 TBC1D4 MAPKBP1	6.28e-05	199	176	8	M8744
Coexpression	GSE9509_LPS_VS_LPS_AND_IL10_STIM_IL10_KO_MACROPHAGE_10MIN_UP	PIK3AP1 EPPK1 RNF19B EXT1 ISG20 PKHD1L1 MYOF ARHGEF10	6.28e-05	199	176	8	M6895
Coexpression	GSE3982_MAC_VS_TH1_DN	USP36 ATP8B4 ISG20 BHLHE40 PRDM2 PITPNM1 PRPF4 CLSPN	6.28e-05	199	176	8	M5511
Coexpression	GSE37301_MULTIPOTENT_PROGENITOR_VS_PRO_BCELL_UP	ACO1 LCT BDKRB2 ARG2 TTC7B NFKB2 PDE4DIP UHRF1	6.50e-05	200	176	8	M8843
Coexpression	GSE2770_IL4_ACT_VS_ACT_CD4_TCELL_2H_DN	USP36 ATP8B4 RAPGEF6 HUWE1 BHLHE40 ATP11B ARAP2 RNF111	6.50e-05	200	176	8	M6095
ToppCell	Control-Myeloid-ncMonocyte\|Myeloid / Disease state, Lineage and Cell class	LRRK2 EXT1 SRGAP2 ISG20 CCDC88C SRGAP2B SCLT1 ARAP2 SEC14L1 NIN	5.46e-09	193	176	10	3479c01aaae7afd7e02d00e0cb21951c0106a0fd
ToppCell	COPD-Endothelial-VE_Peribronchial\|Endothelial / Disease state, Lineage and Cell class	USP36 ANO2 BDKRB2 ZNF385D MYOF MDN1 OTUD4 ARAP2 TPD52L1	8.35e-08	194	176	9	8dcde77767b23e75360adb316cdccf56a00e3726
ToppCell	normal-na-Lymphocytic_T-T4_reg-male\|normal / PBMC cell types (v2) per disease, treatment status, and sex	CPA6 THSD7A MYO18A TSHR TBC1D4 ADGRG2 ARHGEF1 JAKMIP1	2.90e-07	163	176	8	43887e7687fc6367efac0c1f56a9534b06f47b7f
ToppCell	droplet-Heart-nan-24m-Hematologic-coronary_vascular_endothelial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNB1 FLT4 PSKH1 ATP11B MKI67 UHRF1 CLSPN ABCC10	3.49e-07	167	176	8	bad33497ceeab968a7eb8a48b921c6f936390743
ToppCell	Fetal_29-31_weeks-Epithelial-basal_cell-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	FRAS1 VTCN1 MCC ISL1 TRIM29 BHLHE40 SPINK5 CCSER1	3.65e-07	168	176	8	6521bead9789d626b86cbd08692c621c5a5aef33
ToppCell	Fetal_29-31_weeks-Epithelial-basal_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	FRAS1 VTCN1 MCC ISL1 TRIM29 BHLHE40 SPINK5 CCSER1	3.82e-07	169	176	8	c3ee781735a9288ce1822b230d39bb91c1415589
ToppCell	facs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRAS1 AFF2 TMEM217 F8 DENND4C HEATR6 PDE4DIP FAM83G	5.66e-07	178	176	8	fcbbcc44271515de1969b4732b6441c012693d5f
ToppCell	343B-Lymphocytic-CD4_T-cell-Treg_cell_4\|343B / Donor, Lineage, Cell class and subclass (all cells)	ZNF586 CCDC168 ISG20 CCDC88C TADA1 TBC1D4 NFKB2 CLSPN	5.90e-07	179	176	8	c09c3eed43d1aa3b7aa8f3021e6f2737840cde16
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Epithelial-neuroepithelial_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRRC34 TOGARAM2 TSHR CFAP100 CFAP54 CCDC180 METTL15 HYDIN	7.58e-07	185	176	8	05bc89a566b0db90ae06506e067190a4739a0974
ToppCell	COVID-19-Endothelial_cells-Systemic_venous_endothelial_cells\|COVID-19 / group, cell type (main and fine annotations)	ANO2 THSD7A F8 ZNF385D PTPRB TPD52L1 SEC14L1 CCSER1	7.58e-07	185	176	8	f5e14181f45c37d13ee9e017a4c8bc248c353676
ToppCell	COVID-19-Heart-EC_2\|Heart / Disease (COVID-19 only), tissue and cell type	ANO2 THSD7A F8 CCDC88C CFAP54 PTPRB RAPGEF2 SEC14L1	8.21e-07	187	176	8	40ffc06a3e3251d9b12da390210d3e045af7537a
ToppCell	COVID-19-Heart-EC_1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	ANO2 MCC F8 ZNF385D PTPRB RAPGEF2 FRMD3 SEC14L1	8.90e-07	189	176	8	fe49852ba15f948b384d6b4c258927c70b741357
ToppCell	Epithelial-D_(Ciliated)\|World / shred on cell class and cell subclass (v4)	LRRC34 TOGARAM2 DYNC2I1 CFAP100 CFAP54 OSBPL6 CCDC180 HYDIN	8.90e-07	189	176	8	0bf560b595c7a8450a46bc821b742b67965bd9f9
ToppCell	renal_medulla_nuclei-Adult_normal_reference\|renal_medulla_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group	THSD7A DYNC2I1 TEAD1 ARG2 ESYT2 PDE4DIP TPD52L1 SEC14L1	9.26e-07	190	176	8	f1363f7806cfc4f14fbc1b0e8dac2de813a88eee
ToppCell	RV-08._Macrophage\|World / Chamber and Cluster_Paper	PIK3AP1 ATP8B4 DOCK8 RNF213 SRGAP2 COLEC12 MKI67 SRGAP2B	1.00e-06	192	176	8	a1b5dc5beb97a23729b97b54fb4574d10d8fbfb3
ToppCell	Control-Myeloid-ncMonocyte\|Control / Disease state, Lineage and Cell class	LRRK2 EXT1 SRGAP2 CCDC88C SRGAP2B SCLT1 SEC14L1 NIN	1.13e-06	195	176	8	fcb05948e7480dc53f06f3fc9b9c3fc129874edd
ToppCell	Control_saline-Epithelial_airway-airway_epithelial-Ciliated\|Control_saline / Treatment groups by lineage, cell group, cell type	TOGARAM2 KIF24 CFAP100 CFAP54 OSBPL6 VWA3B CCDC180 HYDIN	1.13e-06	195	176	8	60067b5359174f0d1a8b5748bfc0690762e9e740
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Endothelial\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FLT4 THSD7A THSD1 MYZAP PKHD1L1 CCDC88C PTPRB SEC14L1	1.17e-06	196	176	8	629236f95c838a473b5964a49b7c1b7ad863ea12
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TOGARAM2 DYNC2I1 CFAP100 CFAP54 OSBPL6 VWA3B CCDC180 HYDIN	1.22e-06	197	176	8	74a2c6cb8fcfe53dd9a2b36492a16c58f38e51c9
ToppCell	Control_saline-Epithelial_airway\|Control_saline / Treatment groups by lineage, cell group, cell type	VTCN1 TOGARAM2 TEX55 CFAP100 CFAP54 CCDC180 HYDIN SPINK5	1.26e-06	198	176	8	e6863238e022ecfb6a8e3f4b7661b376e92c5d8f
ToppCell	Smart-start-Cell-Wel_seq-Neoplastic-Stem-like-OPC-like-OPC-like-E\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	EPPK1 TOGARAM2 DYNC2I1 CFAP100 KIF9 CFAP54 CLSPN HYDIN	1.26e-06	198	176	8	1847ce8c344c8a3e50f3cbbf758a38aba69f85b0
ToppCell	Control_saline-Epithelial_airway-airway_epithelial\|Control_saline / Treatment groups by lineage, cell group, cell type	VTCN1 TOGARAM2 TEX55 CFAP100 CFAP54 CCDC180 HYDIN SPINK5	1.26e-06	198	176	8	e7aa42e5fbd42c68f50cda4a8f3aa464c862c007
ToppCell	IPF-Endothelial-VE_Peribronchial\|Endothelial / Disease state, Lineage and Cell class	USP36 ANO2 BDKRB2 ZNF385D MYOF MDN1 OTUD4 TPD52L1	1.26e-06	198	176	8	b8bd1ba268480f54451648e01631b615a3401144
ToppCell	control-unassigned\|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SCRN3 BCORL1 STX1A TADA1 ACAD11 ZNF660 SCLT1 CCDC180	1.31e-06	199	176	8	5db7c8089172ac8e796613b3cef618d87007a0ab
ToppCell	LPS_IL1RA-Epithelial_airway-airway_epithelial\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	VTCN1 TEX55 TRIM29 CFAP100 CFAP54 CCDC180 HYDIN SPINK5	1.36e-06	200	176	8	cf191104484bfb2b9f87de416b9453135f8833c1
ToppCell	LPS_IL1RA-Epithelial_airway\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	VTCN1 TEX55 TRIM29 CFAP100 CFAP54 CCDC180 HYDIN SPINK5	1.36e-06	200	176	8	a5ae33dd4dc1ff6e1a1eec22c4d523d5ab657607
ToppCell	Control-Epithelial_airway-Ciliated_cells-Ciliated\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TOGARAM2 ISL1 CFAP100 CFAP54 VWA3B CCDC180 HYDIN	2.72e-06	154	176	7	4e3bc24043144143842627cacf6f90dda2228910
ToppCell	Control-Epithelial_airway-Ciliated_cells\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TOGARAM2 ISL1 CFAP100 CFAP54 VWA3B CCDC180 HYDIN	2.72e-06	154	176	7	7556a4b2b062da5ae7ec2bbb66e745e7662db628
ToppCell	Healthy_Control-Myeloid-Macrophages-FCN1_high\|Healthy_Control / Condition, Lineage, Cell class and cell subclass	BEX1 RNF19B MCC EXT1 ISG20 QRICH2 MYOF	2.84e-06	155	176	7	cd2ccb4632713b4def3a1064599b78207e2e44c0
ToppCell	facs-Liver-Non-hepatocytes-3m-Endothelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT4 TOGARAM2 F8 CEMIP PTPRB OSMR HYDIN	2.84e-06	155	176	7	8fdda4e3657ac56188ae88ed3caf145f4d9d1567
ToppCell	Adult-Endothelial-endothelial_cell_of_artery-D231\|Adult / Lineage, Cell type, age group and donor	ANO2 THSD7A SPTB MCC OVCH1 F8 PTPRB	4.84e-06	168	176	7	aca34c51758c65925ad24110294a72b2dea6db72
ToppCell	facs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRAS1 AFF2 POLR2A F8 DENND4C PDE4DIP FAM83G	6.09e-06	174	176	7	f1fe1f4216748a9562dd03bd48c70b23c7ff4d1d
ToppCell	368C-Endothelial_cells-Endothelial-D\|368C / Donor, Lineage, Cell class and subclass (all cells)	ANO2 THSD7A CHST1 F8 ZNF385D PTPRB TPD52L1	6.32e-06	175	176	7	c4088b5f9fa145869cf5dd8bee7680b1c8fada42
ToppCell	368C-Endothelial_cells-Endothelial-D-\|368C / Donor, Lineage, Cell class and subclass (all cells)	ANO2 THSD7A CHST1 F8 ZNF385D PTPRB TPD52L1	6.32e-06	175	176	7	ca0d3e3a0a271cccdd3881b055fecb626712478d
ToppCell	facs-Limb_Muscle-Muscle_Diaphragm-18m-Lymphocytic-T_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ENGASE BNIP5 UNC13D UHRF1 PRKDC CLSPN TPD52L1	7.07e-06	178	176	7	5ac5257d88fa0dc67714881d6f005f6cea925710
ToppCell	COPD-Endothelial-VE_Venous\|Endothelial / Disease state, Lineage and Cell class	ANO2 EXT1 BDKRB2 ZNF385D MYOF PTPRB TPD52L1	7.33e-06	179	176	7	e816dd846a6918ec143b57a380c3a47ed073b66e
ToppCell	COVID-19-Heart-EC_2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	ANO2 THSD7A MCC F8 PTPRB RAPGEF2 SEC14L1	7.33e-06	179	176	7	2a53d94f6c30bf887dfe88f1693ea057218c852d
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PIK3AP1 MYO9A DOCK8 LRRK2 CFAP54 HYDIN FRMD3	7.88e-06	181	176	7	6956ecd6264f7469a25e555673bce4eb97d28f7a
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Mesenchymal-ependymal_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPPK1 TOGARAM2 CFAP100 KIF9 CFAP54 CCDC180 HYDIN	8.17e-06	182	176	7	587636c0f127231de21acd8aa632b74ff22ca8c2
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Mesenchymal-Ependyma\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPPK1 TOGARAM2 CFAP100 KIF9 CFAP54 CCDC180 HYDIN	8.17e-06	182	176	7	adfadd7893e74b3002f13f00875e3667d3493e0c
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PIK3AP1 DOCK8 LRRK2 CFAP54 TBC1D4 HYDIN FRMD3	8.17e-06	182	176	7	5e1b316599436740f1b30875f0ebd33c3edfb2b6
ToppCell	facs-Lung-nan-3m-Endothelial-Artery_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TEAD2 THSD7A PKHD1L1 MYOF PTPRB FRMD3 SEC14L1	8.47e-06	183	176	7	12e876d6205af8aad74265c668b5e95b9e7487f3
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L4_RORB_CACNG5\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CPA6 THSD7A LRRK2 CEMIP TADA1 CLEC3A SEC14L1	8.77e-06	184	176	7	658f2e522055e88c92bc482a845c40f8f5f1a8e3
ToppCell	COPD-Myeloid-Macrophage_Alveolar\|World / Disease state, Lineage and Cell class	DOCK8 ACO1 DENND4C COLEC12 RASGEF1B ADAM17 CCSER1	8.77e-06	184	176	7	7fd0b227c3750ffb80e41e92c60fcce46656be14
ToppCell	COVID-19-kidney-FLT1+PLVAP+EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	USP36 FLT4 ISG20 BHLHE40 ESYT2 PTPRB SEC14L1	9.09e-06	185	176	7	673308ca0514a4d3629d61fe91e9d8fb31b72166
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	CACNB1 EXT1 STX1A RASGEF1B GOLGA7B ARAP2 TPD52L1	9.41e-06	186	176	7	56c139e679d640ea901ead657a8e8887e0fca098
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PIK3AP1 MYO9A DOCK8 LRRK2 CFAP54 TBC1D4 HYDIN	9.41e-06	186	176	7	5c4ffe4e4d5536ae9f8794277fe032c693e7dd56
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FRAS1 THSD7A MYO9A LAMA1 LRRK2 CFAP54 HYDIN	9.41e-06	186	176	7	f0c8de4f6ae9047b9108a47a2af8c5f42bc103b0
ToppCell	NS-critical-d_16-33-Epithelial-Ciliated\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	LRRC34 TOGARAM2 CFAP100 CFAP54 VWA3B CCDC180 HYDIN	9.41e-06	186	176	7	76033438426d8f9c72cd6691a7baf92104c9f03d
ToppCell	Control-Endothelial-VE_Peribronchial\|Endothelial / Disease state, Lineage and Cell class	USP36 BDKRB2 ZNF385D MYOF OTUD4 ARAP2 TPD52L1	9.75e-06	187	176	7	5429ae85942b8ec3895cceb63c663de3c24ca064
ToppCell	PCW_13-14-Endothelial-Endothelial_immature-endo_immature_arterial2_(6)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	ANO2 FLT4 CHST1 THSD1 BHLHE40 CCDC88C PTPRB	1.01e-05	188	176	7	b66f1f08827dd6c48583d871f9f33ea41e48bfb2
ToppCell	Epithelial-Epithelial-D_(Ciliated)\|Epithelial / shred on cell class and cell subclass (v4)	LRRC34 TOGARAM2 DYNC2I1 CFAP100 CFAP54 CCDC180 HYDIN	1.01e-05	188	176	7	8f30535a32968a81a304315a49c0d90a77d36948
ToppCell	COVID-19-kidney-DCT\|COVID-19 / Disease (COVID-19 only), tissue and cell type	FRAS1 THSD7A LAMA1 ZNF385D ATP6V0A4 TPD52L1 CCSER1	1.01e-05	188	176	7	1d56cd409793f05cca20757ab26e91f1a1ee67b5
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_lymph_vessel-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	FLT4 THSD7A THSD1 PKHD1L1 F8 EYS PTPRB	1.01e-05	188	176	7	2db80767903703e7e0a1a37c598f7877a909ee94
ToppCell	PND10-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated-Ciliated_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	LRRC34 TOGARAM2 CFAP100 CFAP54 OSBPL6 CCDC180 HYDIN	1.04e-05	189	176	7	02c6128a9ab5818e0881dcadafdad5f08b9a67cf
ToppCell	PND10-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	LRRC34 TOGARAM2 CFAP100 CFAP54 OSBPL6 CCDC180 HYDIN	1.04e-05	189	176	7	164ea92ff6a1aa2ead1c9b8f64f99a9d65437232
ToppCell	RA-10._Endothelium_II\|World / Chamber and Cluster_Paper	ANO2 THSD7A EXT1 PKHD1L1 F8 PTPRB OSMR	1.04e-05	189	176	7	75c248b9de5e2fb7a0baa8cdbab516e575cc4394
ToppCell	IPF-Myeloid-ncMonocyte\|Myeloid / Disease state, Lineage and Cell class	LRRK2 EXT1 SRGAP2 ISG20 CCDC88C SCLT1 SEC14L1	1.04e-05	189	176	7	5c22d2d935f7bb270260b8bc6be67b565ec401bf
ToppCell	PND10-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	LRRC34 TOGARAM2 CFAP100 CFAP54 OSBPL6 CCDC180 HYDIN	1.04e-05	189	176	7	a85099bd598a27ee64ee0664d051d89fa8d62fc9
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MYO9A LRRK2 VTCN1 MYOF CFAP54 HYDIN CCSER1	1.08e-05	190	176	7	3fc9e18c7441c0ae8cda65753cc42d0520f4e116
ToppCell	PND14-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	LRRC34 TOGARAM2 CFAP100 CFAP54 OSBPL6 CCDC180 HYDIN	1.08e-05	190	176	7	35248a8be476ea8d06d67c3d98a25be1f7c150b7
ToppCell	PND14-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated-Ciliated_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	LRRC34 TOGARAM2 CFAP100 CFAP54 OSBPL6 CCDC180 HYDIN	1.08e-05	190	176	7	5f5206f9e725070d865f4c891ff08bb750e58582
ToppCell	PCW_10-12-Endothelial-Endothelial_immature-endo_immature_arterial2_(6)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	ANO2 FLT4 CHST1 THSD1 BHLHE40 CCDC88C PTPRB	1.08e-05	190	176	7	7ba2be2630183df86de21689289a8620a4cd507e
ToppCell	COPD-Myeloid-ncMonocyte\|World / Disease state, Lineage and Cell class	LRRK2 EXT1 SRGAP2 ISG20 SRGAP2B SCLT1 SEC14L1	1.08e-05	190	176	7	aece860b5609ad5a8fc920d685f0d0ec71bf9018
ToppCell	COPD-Myeloid-ncMonocyte\|Myeloid / Disease state, Lineage and Cell class	LRRK2 EXT1 ISG20 CCDC88C SCLT1 SEC14L1 NIN	1.08e-05	190	176	7	ed978cd5d9da87b49878a330e362762c487f849f
ToppCell	COVID-19-lung-Artery_EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	ANO2 THSD7A MCC BHLHE40 F8 PTPRB SEC14L1	1.08e-05	190	176	7	07b675befcd1d0a9c90cb17b5d22323468325d51
ToppCell	PND14-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	LRRC34 TOGARAM2 CFAP100 CFAP54 OSBPL6 CCDC180 HYDIN	1.08e-05	190	176	7	088e3f39a1e5e11354d6e7458e8e6a39f14936b3
ToppCell	COVID-19-Heart-EC_+_Pericyte\|Heart / Disease (COVID-19 only), tissue and cell type	ANO2 THSD7A F8 PTPRB RAPGEF2 FRMD3 SEC14L1	1.08e-05	190	176	7	a21653bfb7bafbc273f94fa7c13bfb48cf8fd562
ToppCell	COVID-19-Endothelial_cells\|COVID-19 / group, cell type (main and fine annotations)	ANO2 THSD7A F8 ZNF385D PTPRB ARHGEF10 SEC14L1	1.08e-05	190	176	7	9fbd92cd6d4683b2490504d29c43cf42020433d4
ToppCell	PND03-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	LRRC34 DYNC2I1 CFAP100 CFAP54 OSBPL6 CCDC180 HYDIN	1.12e-05	191	176	7	bda8faf92495c8b362850c0aff4fc6fbdd9c563b
ToppCell	PND03-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated-Ciliated_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	LRRC34 DYNC2I1 CFAP100 CFAP54 OSBPL6 CCDC180 HYDIN	1.12e-05	191	176	7	6880fb348bb0915db9a5da4f3566ca9ff93ed258
ToppCell	IPF-Myeloid-ncMonocyte\|IPF / Disease state, Lineage and Cell class	LRRK2 EXT1 SRGAP2 ISG20 SRGAP2B SCLT1 SEC14L1	1.16e-05	192	176	7	e9fb8c57d8094f70fb492909b2bec40aa5f2e5b8
ToppCell	PND03-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	LRRC34 DYNC2I1 CFAP100 CFAP54 OSBPL6 CCDC180 HYDIN	1.16e-05	192	176	7	b5cdc2dae3154b1e4ade88f841f38584402ffe33
ToppCell	LV-08._Macrophage\|LV / Chamber and Cluster_Paper	PIK3AP1 ATP8B4 DOCK8 SRGAP2 COLEC12 SRGAP2B ARAP2	1.16e-05	192	176	7	7be12d580aaf2f2f1562203fcad3a44639b8c5a6
ToppCell	droplet-Pancreas-Exocrine-18m-Endothelial-nan\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT4 CHST1 MYZAP MYOF PTPRB MKI67 NIN	1.16e-05	192	176	7	a42aed9e563f5f4af029b8804c104f11ad227a8f
ToppCell	PND03-Epithelial-Epithelial_Airway\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	LRRC34 DYNC2I1 CFAP100 CFAP54 OSBPL6 CCDC180 HYDIN	1.16e-05	192	176	7	2d8d5a38e205339eda9c8aca1ca9ba3dcbe5ae56
ToppCell	3'-GW_trimst-1-LargeIntestine-Endothelial-blood_vessel_EC-Fetal_arterial_EC\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FLT4 THSD7A CHST1 THSD1 BHLHE40 PTPRB SEC14L1	1.16e-05	192	176	7	1f35efb0765e05f7f9c881849953bef3965be25a
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MYO9A LAMA1 ZNF385D TBC1D4 PDE4DIP MST1L CCSER1	1.16e-05	192	176	7	ee27d27e3d269764dbe8711d0b37ff9331a298a9
ToppCell	RV-08._Macrophage\|RV / Chamber and Cluster_Paper	PIK3AP1 ATP8B4 DOCK8 SRGAP2 COLEC12 MKI67 SRGAP2B	1.20e-05	193	176	7	12bf98a280f87e4d8f0c6887dfc855da72e47ac1
ToppCell	RV-09._Endothelium_I\|World / Chamber and Cluster_Paper	ANO2 FLT4 F8 PTPRB FRMD3 SEC14L1 SPINK5	1.20e-05	193	176	7	e3fa47e2c7cd8a5b69186711c57751f2296de8ae
ToppCell	Fetal_29-31_weeks-Endothelial-capillary_endothelial_cell_(Cap1)-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ANO2 TEAD2 FLT4 MCC THSD1 PTPRB SEC14L1	1.20e-05	193	176	7	ad2df9b77999780860141be6ec366afc0172a331
ToppCell	moderate-Myeloid-Monocyte-derived_Macrophage\|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	MYH7 TMEM217 RNF19B RNF213 SRGAP2 ISG20 MYOF	1.20e-05	193	176	7	22455801194bd8c73c5c397f5eac4f723429c383
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	MYO9A LRRK2 RNF213 MYOF TBC1D4 HYDIN CCSER1	1.24e-05	194	176	7	e577d9e88390b36b5a09b97fe1026089892275a3
ToppCell	NS-critical-d_07-13-Epithelial-Ciliated\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	LRRC34 TOGARAM2 CFAP100 CFAP54 VWA3B CCDC180 HYDIN	1.24e-05	194	176	7	1ae8a10e508e672e6677f0e3c986ac30d05adeb3
ToppCell	systemic_lupus_erythematosus-flare-Lymphocytic-lymphocyte-male\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	ACO1 POLA2 MKI67 JAKMIP1 CLSPN FRMD3 ZNF222	1.24e-05	194	176	7	8f4b63b0b9a40765205e4ca6bd94a675a83dbe3d
ToppCell	RV-09._Endothelium_I\|RV / Chamber and Cluster_Paper	ANO2 FLT4 F8 PTPRB FRMD3 SEC14L1 SPINK5	1.24e-05	194	176	7	7b408096e717f2327c12aea35a8d5fc4621d3b06
ToppCell	LA-08._Macrophage\|World / Chamber and Cluster_Paper	PIK3AP1 ATP8B4 DOCK8 SRGAP2 COLEC12 SRGAP2B ARAP2	1.24e-05	194	176	7	c1805572bcc11b1cd29083329d7b5911489fb758
ToppCell	10x_3'_v2v3-Non-neoplastic-Lymphoid-CD4/CD8-CD8_cytotoxic-C\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	RAPGEF6 RNF213 ISG20 TSHR CCDC88C MDN1 ACAD11	1.28e-05	195	176	7	83c125223e7ca0f08a31414b3a16347912564765
ToppCell	IPF-Endothelial-VE_Peribronchial\|World / Disease state, Lineage and Cell class	ANO2 THSD7A BDKRB2 ZNF385D PTPRB OSMR TPD52L1	1.28e-05	195	176	7	120296531bbc8080dcabacbd64733cc1dc34603a
ToppCell	background-Endothelial_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	FLT4 THSD7A F8 PTPRB RASGEF1B OSMR CCSER1	1.28e-05	195	176	7	c7d60dabfc7cb310e002cab10003dadfcc34fe33
ToppCell	moderate-Epithelial-Ciliated\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	LRRC34 TOGARAM2 CFAP100 CFAP54 VWA3B CCDC180 HYDIN	1.28e-05	195	176	7	3486eae5fdb062a75a907b896c9d7b396d2aa195
ToppCell	Tracheal-NucSeq-Endothelial-Endothelia_lymphatic-Endothelia_Lymphatic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ANO2 FLT4 THSD1 PKHD1L1 F8 COLEC12 PTPRB	1.32e-05	196	176	7	09a7edf4a7defb7fe70d9777dd9500ee8421ff31
ToppCell	Tracheal-NucSeq-Endothelial-Endothelia_lymphatic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ANO2 FLT4 THSD1 PKHD1L1 F8 COLEC12 PTPRB	1.32e-05	196	176	7	e50d2c66d5c5cd25fdfecdcc4c8506a1d0a85755
ToppCell	background-Endothelial_cells\|background / Sample and Cell Type and Tumor Cluster (all cells)	FLT4 THSD7A F8 DENND4C PTPRB SEC14L1 CCSER1	1.32e-05	196	176	7	e6fb0bfab1779ec64a8c35d01519eaafbf62e977
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FRAS1 MYO9A LAMA1 LRRK2 ATP6V0A4 HYDIN CCSER1	1.32e-05	196	176	7	6ce74aa3f0ce3ca284b67e5a4660ffd2cc9611e0
ToppCell	3'-GW_trimst-1-SmallIntestine-Endothelial-blood_vessel_EC-Fetal_arterial_EC\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FLT4 THSD7A THSD1 BHLHE40 CCDC88C PTPRB SEC14L1	1.37e-05	197	176	7	98e34e8612f111bb667a574de1faaa785d318ca4
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	EPPK1 TRIM29 CEMIP MYOF MKI67 UHRF1 CLSPN	1.37e-05	197	176	7	2430f31d9312338e0ca23bfc6bdb0365340860fd
ToppCell	Tracheal-NucSeq-Endothelial-Endothelia_vascular-VE_systemic_venous\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ANO2 TEAD2 FLT4 THSD7A ZNF385D PTPRB SEC14L1	1.41e-05	198	176	7	5c82dad416938d5c460069796d808170e7dbc8d9
ToppCell	ASK428-Endothelial\|ASK428 / Donor, Lineage and Cell class of Lung cells from Dropseq	FLT4 MCC THSD1 PKHD1L1 F8 ZNF385D PTPRB	1.41e-05	198	176	7	d69d0ff115298596173a4278897a65007a71f5df
ToppCell	5'-Adult-Appendix-Endothelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FLT4 THSD7A PKHD1L1 F8 ZNF385D PTPRB OSMR	1.41e-05	198	176	7	90e85fe7a0ab376a41666dfff6c0e95b7f1c9475
Drug	Natamycin [7681-93-8]; Up 200; 6uM; MCF7; HT_HG-U133A	FLT4 TRIM29 BDKRB2 PITPNM1 NFKB2 ATP6V0A4 PDE4DIP ADAM17 OSMR SPINK5	3.12e-06	196	176	10	7167_UP
Drug	Aconitine [302-27-2]; Down 200; 6.2uM; MCF7; HT_HG-U133A	BCORL1 ISG20 THSD1 MYOF ZNF35 ADGRG2 ARHGEF10 IKBKE NFKB2 PDE4DIP	3.27e-06	197	176	10	6797_DN
Drug	prochlorperazine dimaleate salt; Up 200; 10uM; MCF7; HT_HG-U133A_EA	ISG20 TRIM29 BHLHE40 BDKRB2 CEMIP PITPNM1 ARHGEF10 PDE4DIP OTUD4	8.40e-06	173	176	9	995_UP
Drug	Methamphetamine	CBLL1 PIK3AP1 MYH7 PCNX3 SWT1 ACO1 ZNF189 MYO18A MCC LAMP2 SRGAP2 ISG20 THSD1 POLA2 ZZEF1 CBR1 PRDM2 ARG2 ZNF385D TADA1 TBC1D4 ARHGEF10 ARHGEF1 PDE4DIP MKI67 FASTKD3 SEC14L1	1.03e-05	1401	176	27	ctd:D008694
Drug	Conessine [546-06-5]; Down 200; 11.2uM; MCF7; HT_HG-U133A	FRAS1 FLT4 EPPK1 DYNC2I1 ZZEF1 PITPNM1 TBC1D4 IKBKE NFKB2	2.10e-05	194	176	9	2792_DN
Drug	Ritodrine hydrochloride [23239-51-2]; Down 200; 12.4uM; MCF7; HT_HG-U133A	USP36 CCDC186 RNF19B DYNC2I1 ADGRG2 PDE4DIP OSMR SEC14L1 SPINK5	2.28e-05	196	176	9	5680_DN
Drug	Dicloxacillin sodium salt [13412-64-1]; Down 200; 8.2uM; PC3; HT_HG-U133A	CACNB1 ITSN1 ISL1 ARHGEF1 NFKB2 PDE4DIP ADAM17 MTSS2 SPINK5	2.28e-05	196	176	9	6666_DN
Drug	Spironolactone [52-01-7]; Up 200; 9.6uM; PC3; HT_HG-U133A	CACNB1 FLT4 POLR2A HUWE1 PRDM2 COLEC12 OTUD4 MTSS2 SPINK5	2.28e-05	196	176	9	5781_UP
Drug	Meclofenoxate hydrochloride [3685-84-5]; Down 200; 13.6uM; MCF7; HT_HG-U133A	USP36 AFF2 CCDC186 EXT1 PRDM2 ZNF35 ADGRG2 IKBKE ARHGEF1	2.47e-05	198	176	9	4729_DN
Disease	uric acid measurement	SHLD2 FRAS1 FLT4 RPS6KA4 PCNX3 SWT1 MYO9A TSHR POLA2 QRICH2 CEMIP MYOF ZNF816	5.38e-05	610	169	13	EFO_0004761
Disease	Cleft palate, cleft lip, alcohol exposure measurement, parental genotype effect measurement	ANO2 ARHGEF10	3.22e-04	5	169	2	EFO_0003959, EFO_0005939, EFO_0009113, HP_0000175
Disease	YKL40 measurement, cerebrospinal fluid biomarker measurement	MYOF EYS	3.22e-04	5	169	2	EFO_0004869, EFO_0006794
Disease	response to platinum based chemotherapy, cytotoxicity measurement	FRAS1 EYS	3.22e-04	5	169	2	EFO_0004647, EFO_0006952
Disease	Cerebral ventriculomegaly	CCDC88C HYDIN	6.72e-04	7	169	2	C1531647
Disease	Hydrocephalus Ex-Vacuo	CCDC88C HYDIN	6.72e-04	7	169	2	C0270720
Disease	Communicating Hydrocephalus	CCDC88C HYDIN	6.72e-04	7	169	2	C0009451
Disease	Fetal Cerebral Ventriculomegaly	CCDC88C HYDIN	6.72e-04	7	169	2	C2936718
Disease	Post-Traumatic Hydrocephalus	CCDC88C HYDIN	6.72e-04	7	169	2	C0477432
Disease	Obstructive Hydrocephalus	CCDC88C HYDIN	6.72e-04	7	169	2	C0549423
Disease	AUTISM, SUSCEPTIBILITY TO, 15	POLR2A WDR37	8.93e-04	8	169	2	C2677504
Disease	Congenital Hydrocephalus	CCDC88C HYDIN	8.93e-04	8	169	2	C0020256
Disease	Aqueductal Stenosis	CCDC88C HYDIN	8.93e-04	8	169	2	C2936786
Disease	Hydrocephalus	CCDC88C HYDIN	1.14e-03	9	169	2	C0020255
Disease	severe acute respiratory syndrome, COVID-19	THSD7A SRGAP2 HELQ KSR1 NLN EYS PDE4DIP RASGEF1B ELP2	1.15e-03	447	169	9	EFO_0000694, MONDO_0100096
Disease	Profound Mental Retardation	DOCK8 LAMA1 MCC ELP2 DYNC1H1	1.26e-03	139	169	5	C0020796
Disease	Mental Retardation, Psychosocial	DOCK8 LAMA1 MCC ELP2 DYNC1H1	1.26e-03	139	169	5	C0025363
Disease	Mental deficiency	DOCK8 LAMA1 MCC ELP2 DYNC1H1	1.26e-03	139	169	5	C0917816
Disease	theophylline measurement	LRRK2 CCSER1	1.42e-03	10	169	2	EFO_0021180
Disease	thyroid gland carcinoma (is_marker_for)	FLT4 PTPRB	2.07e-03	12	169	2	DOID:3963 (is_marker_for)
Disease	Autosomal Dominant Myotubular Myopathy	MYH7 MTMR14	2.44e-03	13	169	2	C3661489
Disease	Centronuclear myopathy	MYH7 MTMR14	2.44e-03	13	169	2	C0175709
Disease	X-linked centronuclear myopathy	MYH7 MTMR14	2.44e-03	13	169	2	C0410203
Disease	Myopathy, Centronuclear, 1	MYH7 MTMR14	2.44e-03	13	169	2	C4551952
Disease	Congenital Structural Myopathy	MYH7 MTMR14	2.44e-03	13	169	2	C0752282
Disease	Myopathy, Centronuclear, Autosomal Dominant	MYH7 MTMR14	2.84e-03	14	169	2	C1834558
Disease	Tubular Aggregate Myopathy	MYH7 MTMR14	2.84e-03	14	169	2	C0410207
Disease	asymmetric dimethylarginine measurement	MTHFS ZZEF1	2.84e-03	14	169	2	EFO_0010463
Disease	asthma, body mass index	USP36 UNC13D	2.84e-03	14	169	2	EFO_0004340, MONDO_0004979
Disease	Autosomal Recessive Centronuclear Myopathy	MYH7 MTMR14	3.26e-03	15	169	2	C3645536
Disease	serum IgG glycosylation measurement	PIK3AP1 ANO2 CACNB1 THSD7A ACO1 TSHR ZNF385D EYS JAKMIP1	3.31e-03	523	169	9	EFO_0005193
Disease	Metastatic melanoma	FLT4 MAST1 PRKDC	3.70e-03	54	169	3	C0278883
Disease	level of Phosphatidylethanolamine (16:0_20:4) in blood serum	MYZAP RNF111	3.71e-03	16	169	2	OBA_2045137
Disease	pyruvate measurement	MYO18A ISG20 TSHR OTUD4 HYDIN CCSER1	4.59e-03	268	169	6	EFO_0010117
Disease	Congenital Fiber Type Disproportion	MYH7 MTMR14	4.70e-03	18	169	2	C0546264
Disease	Hallux valgus	TSHR EYS ARHGEF1	4.97e-03	60	169	3	HP_0001822
Disease	cardiomyopathy (is_implicated_in)	MYH7 TSHR	5.23e-03	19	169	2	DOID:0050700 (is_implicated_in)
Disease	level of Phosphatidylethanolamine (18:0_20:4) in blood serum	MYZAP RNF111	5.23e-03	19	169	2	OBA_2045140
Disease	hypertension, white matter hyperintensity measurement	ZNF385D CCDC88C ZNF106	5.45e-03	62	169	3	EFO_0000537, EFO_0005665
Disease	urate measurement	SHLD2 TMCO5A RPS6KA4 PCNX3 MYO9A EXT1 CHST1 TRIM29 QRICH2 CEMIP ZNF816 UHRF1	5.60e-03	895	169	12	EFO_0004531

Protein segments in the cluster

Peptide	Gene	Start	Entry
ARLERKNKTLVHSIT	TMCO5A	86	Q8N6Q1
VNSETQLKQHISSRR	ZNF385D	276	Q9H6B1
TSTDIVLTITKHLRQ	ACO1	256	P21399
QLTIRHSSQRNKLIV	ESYT2	791	A0FGR8
RTSISVERQIHKLQD	BDKRB2	371	P30411
VTQRRKHASSIKDLT	CCDC186	681	Q7Z3E2
QDERLLLKSHSRTLT	ARHGEF1	681	Q92888
RTKSLIAQDHRSSLE	ARHGEF10	376	O15013
LSNIITITQRRLHSD	CFAP54	1061	Q96N23
SLSRLLQTRVHSILK	ARG2	6	P78540
KHIIIERSNTRSSLA	CACNB1	286	Q02641
LREKQLSHSLRAVST	BEX1	96	Q9HBH7
ENTRDLKSSQLVTHL	BHLHE40	161	O14503
VVILNSTLIHSNRKS	AFF2	141	P51816
RNLTRNVTVTLKHIN	ADGRG2	546	Q8IZP9
QKTSSSQSLEHRLRN	BCORL1	1366	Q5H9F3
TLAIRIQSIHLSSSK	BTBD11	1086	A6QL63
RTQKALILDSVNRHS	ARAP2	436	Q8WZ64
TNLKVRHALSVTSEL	ATP8B4	171	Q8TF62
IVSQNLSTRDRKAIH	CCSER1	746	Q9C0I3
RLQQTQSLHSLRSIS	DFFA	296	O00273
ALSLNKATRSNVRVT	ANO2	566	Q9NQ90
ATRSQKLVTLSNTLH	CCDC180	991	Q9P1Z9
FLSSRQVRSQKILTH	PIK3AP1	31	Q6ZUJ8
LEKGSSLHTQRNRRS	CPA6	116	Q8N4T0
SILSDVHNRLLKQTS	CEMIP	1091	Q8WUJ3
IVLGRTQNTSLSRHK	ACAD11	551	Q709F0
QNLTKSTENHRLRRS	CDK5RAP2	386	Q96SN8
RESLSRKTVSLEHLQ	CDK5RAP2	1481	Q96SN8
SLKVSTNSTRQSLHL	OSMR	36	Q99650
SEHKNLSRTPSQIIR	OTUD4	406	Q01804
SNKRLRQVSSLVLHI	RASA1	586	P20936
STKASSQIIRELLHA	QRICH2	1516	Q9H0J4
RVLSERLLHKSIQNS	ISG20	131	Q96AZ6
AKRNHLRVVDSLQTS	MYH7	1586	P12883
NERKSEQHLRFLSTL	LTN1	606	O94822
RSRESLSVHQTLSAI	ANKRD31	1321	Q8N7Z5
RQSRVLSQKVIAHSE	MTHFS	31	P49914
KTVLTIAHRLNTILN	ABCC10	1431	Q5T3U5
LQLRVKHANETSLSI	PTPRB	471	P23467
LTSHNRSLKALSVVS	LRRC34	346	Q8IZ02
THRSTAKLLSVLAQV	MDN1	4631	Q9NU22
RSEIHSINITIERKN	FRAS1	1941	Q86XX4
ISKQVTILNSSALHR	EYS	1501	Q5T1H1
SHISTDLRQKNTRAS	MST1L	281	Q2TV78
STVQVSKLQDLIHRS	MTMR14	106	Q8NCE2
NLIRQTNTHIRSTGK	SPINK5	1031	Q9NQ38
HNLQELRRSASLATK	GOLGA7B	6	Q2TAP0
QNSVIASRARKTLTA	HPS5	381	Q9UPZ3
SSLNRELVKSRDQVH	IKBKE	521	Q14164
NLHRSISQNLLKRAS	PSKH1	366	P11801
NRKVSSLHTSRVQRQ	DYNC2I1	641	Q8WVS4
LTKQVTVHARTLTTL	CCDC88C	896	Q9P219
KRVDHSNTRLVTQLD	PCNX3	1316	Q9H6A9
LTRSKSHESQLGNRI	KSR1	306	Q8IVT5
ATKLHSQLRTTVLAA	MTSS2	36	Q765P7
LLVSLVNRALKSSQH	MYO18A	766	Q92614
HLRTLTSNLNEVRTT	COLEC12	356	Q5KU26
IRHKDVNVRVSSLTL	HEATR6	571	Q6AI08
RHLQTSSLRIKSQEL	KIF24	76	Q5T7B8
QRSKILTTRLHSLEE	KRT25	431	Q7Z3Z0
KVGNRSELQHLATSR	LCT	1171	P09848
QDKASLTRTLQHRIA	LRRK2	1961	Q5S007
RSHTALLRLNSSTIK	LAMP2	266	P13473
VLKRHQREITRTTLQ	F8	1661	P00451
SLKRHTSLNDLSLTR	JAKMIP1	376	Q96N16
ALVQRAKTQEHTRTE	RPS6KA4	71	O75676
SKRVSISRSQHDILQ	MKI67	626	P46013
RRKRASETTQHINAI	KIF9	606	Q9HAQ2
RSTHIATKTFQALRI	METTL15	276	A6NJ78
AQRSLTAHSSREKIV	RASGEF1B	356	Q0VAM2
THRTVLNQILRQSTT	HUWE1	3961	Q7Z6Z7
TSSQRDSRQSIHILE	OSBPL6	26	Q9BZF3
RKITKQSNLLHTSRS	MAST1	1096	Q9Y2H9
TFRISTRKHSNLITV	CBLL1	281	Q75N03
TQSRSSHSLNKQLII	FRMD3	361	A2A2Y4
RLTKSSEIRHQQSAE	MCC	746	P23508
VRSKHTQTILLSNRT	HYDIN	4641	Q4G0P3
TLRSQVAHSSKLDRN	BNIP5	581	P0C671
VQRKAVSAIHSLLSS	DOCK8	1181	Q8NF50
STIRSIHQDKILALR	EXT1	391	Q16394
QQNSLHRDSLVTLKR	ITSN1	556	Q15811
NSLSKRNVSLTRSHS	DENND4C	1626	Q5VZ89
SAKHTSLRRQLQLED	CFAP100	96	Q494V2
VTVLSRIHARKLSEQ	CBR1	201	P16152
STLHRNILSSDLIKI	MAPKBP1	436	O60336
VHQRDVTRSLIKSKI	DYNC1H1	1816	Q14204
ISVLNAETSSRHSLR	ENGASE	526	Q8NFI3
ETSQSQSHTLAIRKL	ELP2	771	Q6IA86
DTLRIIRLSHSASKQ	CCDC168	866	Q8NDH2
TVTHRIRKQSLQSQI	FCRL2	181	Q96LA5
DHLSRRQAKQIVSSA	HELQ	1051	Q8TDG4
VQKNSLNSRERTLHI	SEC14L1	81	Q92503
DAQSLISISLRKIHS	IER5L	6	Q5T953
ISISLRKIHSSRTQR	IER5L	11	Q5T953
AQLSSKTSRSLHVRV	PRDM2	1601	Q13029
TTRVRTVLNEKQLHT	ISL2	191	Q96A47
RIKIRDTSQASAQHQ	FAM83G	446	A6ND36
IKLRNAIHLSNLTVS	TAS2R36	166	P0DTE0
KQTREQLHSISDSVL	TRIM29	361	Q14134
TSEQITHRLSKLSER	TEX55	206	Q96M34
QQRAQTLRVRTKHTS	RNF19B	256	Q6ZMZ0
EILRNNTHLALTVKT	RAPGEF6	596	Q8TEU7
LSRNKETELLRQTHS	SPATA22	166	Q8NHS9
LDEARKNLLRTHTTS	FARSA	316	Q9Y285
DSSIRKQSRHRVIIQ	THSD7A	791	Q9UPZ6
NHLKDILTSVVSRRK	TADA1	181	Q96BN2
TNLRSKVSHLAISTL	TOGARAM2	541	Q6ZUX3
LTLRNTTLFLRHNKD	LINC00869	86	P0C866
THSREKVRQLESNLL	NIN	1871	Q8N4C6
TRTSQMQELHKSLRS	PRPF4	206	O43172
ISNQLSITTKIAREH	SCRN3	186	Q0VDG4
KITRLSQSSNREHLV	OVCH1	966	Q7RTY7
KESHLDTLSRAQLTQ	FASTKD3	481	Q14CZ7
ASLSRVNTTLRETHQ	LAMA1	2041	P25391
NSRVIDQKTLHTLRV	EPPK1	1861	P58107
SEVQRRIHLQTKSDS	SETMAR	176	Q53H47
NIESQKIHSSRLSDI	SHLD2	101	Q86V20
LLLNQVKRESRDHTT	SRGAP2B	101	P0DMP2
TRKQVSSHIQVLARR	TEAD2	96	Q15562
TSDRFSRILKHILTQ	POLA2	491	Q14181
TTRVRTVLNEKQLHT	ISL1	181	P61371
SLNVTRQKTEHLLSD	SWT1	276	Q5T5J6
LRIRSTQGQHKAIST	OR8U3	226	Q8NH85
TINKNARATLSSIRH	RPL28	81	P46779
QISRHNETKALSETL	SIX6OS1	226	Q8N1H7
RLQKRHQQLESESRT	SPTBN5	1456	Q9NRC6
SVVIQASKSRRHRQV	SNAPC1	271	Q16533
SLSNIQQHSVRKRDL	ADAM17	46	P78536
RKRDLQTSTHVETLL	ADAM17	56	P78536
NLSRKTHILILATTR	CHST1	56	O43916
LLDQTTSHTSRLKAR	CLEC3A	16	O75596
LKQLHSETQRLIRES	CLSPN	286	Q9HAW4
TEHQRNSSKILRFIS	ATP11B	326	Q9Y2G3
LRQIVLSKVDQSLHT	NLN	576	Q9BYT8
TRQTSHLQARSLSEI	DNTTIP2	241	Q5QJE6
SLANETHQLRRTLTA	TNIP2	146	Q8NFZ5
VKIRNVTSNHRASDT	PITPNM1	911	O00562
EILRNNTHLSITVKT	RAPGEF2	451	Q9Y4G8
RHSQDLSSKRLNDTV	RNF213	1181	Q63HN8
KTFTRSSNLIVHQRI	ZNF35	341	P13682
KTFSVSSTLIRHQRI	ZNF189	211	O75820
QSSSLLQRQTLHTRE	ZNF586	161	Q9NXT0
SKRFTIHRSSNVLTL	USP42	301	Q9H9J4
IHRSSNVLTLSLKRF	USP42	306	Q9H9J4
VSVRHSQTILNAKSR	RNF111	161	Q6ZNA4
SQTILNAKSRSHSAR	RNF111	166	Q6ZNA4
LNRSSADLRIRKTQH	STX1A	106	Q16623
ADLRIRKTQHSTLSR	STX1A	111	Q16623
NILHKTDQTLRRIVS	PSTK	271	Q8IV42
LEHTTLRKVTANTAI	POLR2A	1161	P24928
SQTLIRKSQARHVGS	THSD1	621	Q9NS62
LLLNQVKRESRDHTT	SRGAP2	101	O75044
LNSISRHSSLKNRLD	SRGAP2	901	O75044
ERRSQQTHTELSSIL	FLT4	281	P35916
KTFRQTSQVILHLRT	ZNF660	281	Q6AZW8
SELSRQKLHTQELLS	SCLT1	611	Q96NL6
KTQHLSAARSSDLRL	SPTB	1371	P11277
TNVSLQRISLHKASE	PKHD1L1	806	Q86WI1
AKLVIQRHLSSLTDN	TBC1D4	476	O60343
LHQSRLTKLQSVQAL	PRKDC	3121	P78527
TTLRQVLSAKERHLV	TPD52L1	51	Q16890
ILRASHRKSQLQASR	ATP6V0A4	661	Q9HBG4
QKRKSHSLSIRRTNS	WDR37	16	Q9Y2I8
RQTHTVDSLSRLTKV	UHRF1	11	Q96T88
HKSDRLISLQSASVV	TTC7B	351	Q86TV6
DQSLSHRSVVKVLSL	ZZEF1	1566	O43149
KSFTQSSGLIRHQRI	ZSCAN9	261	O15535
VLHAESTKTSLLRSQ	VWA3B	766	Q502W6
TRKQVSSHIQVLARR	TEAD1	86	P28347
TAEILHSRNKRLSIS	TMEM217	171	Q8N7C4
KTFTLSATLLRHQRT	ZNF629	381	Q9UEG4
NSSALHSLLKRVVST	VIRMA	1371	Q69YN4
QLIHKRRATSASRSQ	UNC13D	281	Q70J99
ASLQRDLTRHISLKS	ZNF106	726	Q9H2Y7
KSFLTSSRLIQHIRT	ZNF426	371	Q9BUY5
ASKRFTIHRTSNVLT	USP36	311	Q9P275
TIHRTSNVLTLSLKR	USP36	316	Q9P275
ESQRISCRLKTHISN	ZNF816	191	Q0VGE8
SQIKARLSTVHTREK	ZNF222	101	Q9UK12
TESEIKRRSHLQLLN	VTCN1	241	Q7Z7D3
SKVTHIEIRNTRNLT	TSHR	101	P16473
SLKHLTRLTLQDRIT	MYO9A	861	B2RTY4
TRLTLQDRITKSLLH	MYO9A	866	B2RTY4
QIRKLRSRSLSQIHE	MYOF	721	Q9NZM1
VSKQERLLQSTTEHL	PDE4DIP	2286	Q5VU43
SQLTRTHDVLKKART	PDE4DIP	2316	Q5VU43
RQKIRQLTQELSVSH	MYZAP	126	P0CAP1
THLVTKLRANVNART	NFKB2	651	Q00653