Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionG protein-coupled receptor activity

VN1R4 TAS2R16 ADRA1D OR8U1 OR8B4 SSTR1 OR11H2 GPR176 OR1L1 CNR2 OR8U8 OR4E1

2.46e-088843612GO:0004930
GeneOntologyMolecularFunctiontransmembrane signaling receptor activity

VN1R4 TAS2R16 ERBB3 ERBB4 ADRA1D OR8U1 OR8B4 SSTR1 OR11H2 GPR176 OR1L1 CNR2 OR8U8 OR4E1

3.71e-0813533614GO:0004888
GeneOntologyMolecularFunctionodorant binding

VN1R4 OR8U1 OR8B4 OR8U8 OR4E1

3.09e-06127365GO:0005549
GeneOntologyMolecularFunctionneuregulin receptor activity

ERBB3 ERBB4

9.47e-063362GO:0038131
GeneOntologyMolecularFunctionneuregulin binding

ERBB3 ERBB4

4.72e-056362GO:0038132
GeneOntologyMolecularFunctionolfactory receptor activity

OR8U1 OR8B4 OR11H2 OR1L1 OR8U8 OR4E1

1.10e-04431366GO:0004984
GeneOntologyBiologicalProcesssensory perception of chemical stimulus

VN1R4 TAS2R16 OR8U1 OR8B4 OR11H2 CNGA4 OR1L1 OR8U8 OR4E1

3.02e-07547369GO:0007606
GeneOntologyBiologicalProcessG protein-coupled receptor signaling pathway

VN1R4 TAS2R16 ADRA1D OR8U1 OR8B4 SSTR1 OR11H2 GPR176 OR1L1 CNR2 OR8U8 OR4E1

2.38e-0613953612GO:0007186
GeneOntologyBiologicalProcesssensory perception of smell

OR8U1 OR8B4 OR11H2 CNGA4 OR1L1 OR8U8 OR4E1

1.34e-05465367GO:0007608
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception

TAS2R16 OR8U1 OR8B4 OR11H2 OR1L1 OR8U8 OR4E1

1.76e-05485367GO:0050907
GeneOntologyBiologicalProcessdetection of chemical stimulus

TAS2R16 OR8U1 OR8B4 OR11H2 OR1L1 OR8U8 OR4E1

2.89e-05524367GO:0009593
GeneOntologyBiologicalProcessdetection of stimulus involved in sensory perception

TAS2R16 OR8U1 OR8B4 OR11H2 OR1L1 OR8U8 OR4E1

5.63e-05582367GO:0050906
GeneOntologyBiologicalProcesssensory perception

VN1R4 TAS2R16 OR8U1 OR8B4 OR11H2 CNGA4 OR1L1 OR8U8 OR4E1

7.05e-051072369GO:0007600
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception of smell

OR8U1 OR8B4 OR11H2 OR1L1 OR8U8 OR4E1

9.32e-05432366GO:0050911
GeneOntologyBiologicalProcessdetection of stimulus

TAS2R16 OR8U1 OR8B4 OR11H2 OR1L1 OR8U8 OR4E1

2.15e-04722367GO:0051606
GeneOntologyBiologicalProcessmammary gland epithelial cell differentiation

IRF6 ERBB4

4.97e-0419362GO:0060644
GeneOntologyBiologicalProcesspositive regulation of synaptic transmission

SLC8A2 ERBB4 CACNG5 CLSTN2

7.04e-04233364GO:0050806
MousePhenodecreased transitional stage T3 B cell number

ATP11C SPPL2A

7.09e-063222MP:0010228
MousePhenoabnormal transitional stage T3 B cell morphology

ATP11C SPPL2A

1.42e-054222MP:0009921
DomainGPCR_Rhodpsn_7TM

VN1R4 ADRA1D OR8U1 OR8B4 SSTR1 OR11H2 GPR176 OR1L1 CNR2 OR8U8

1.98e-076703410IPR017452
DomainG_PROTEIN_RECEP_F1_2

VN1R4 ADRA1D OR8U1 OR8B4 SSTR1 OR11H2 GPR176 OR1L1 CNR2 OR8U8

2.64e-076913410PS50262
DomainGPCR_Rhodpsn

VN1R4 ADRA1D OR8U1 OR8B4 SSTR1 OR11H2 GPR176 OR1L1 CNR2 OR8U8

2.67e-076923410IPR000276
DomainG_PROTEIN_RECEP_F1_1

VN1R4 ADRA1D OR8U1 OR8B4 SSTR1 GPR176 OR1L1 CNR2 OR8U8

2.62e-06685349PS00237
DomainTyr_kinase_EGF/ERB/XmrK_rcpt

ERBB3 ERBB4

1.93e-054342IPR016245
Domain7tm_1

ADRA1D OR8U1 OR8B4 SSTR1 GPR176 OR1L1 CNR2 OR8U8

2.25e-05677348PF00001
DomainGF_recep_IV

ERBB3 ERBB4

4.80e-056342PF14843
DomainGF_recep_IV

ERBB3 ERBB4

4.80e-056342IPR032778
DomainFurin-like

ERBB3 ERBB4

6.72e-057342PF00757
DomainRcpt_L-dom

ERBB3 ERBB4

6.72e-057342IPR000494
DomainFurin-like_Cys-rich_dom

ERBB3 ERBB4

6.72e-057342IPR006211
DomainRecep_L_domain

ERBB3 ERBB4

6.72e-057342PF01030
Domain-

ERBB3 ERBB4

6.72e-0573423.80.20.20
DomainFurin_repeat

ERBB3 ERBB4

4.83e-0418342IPR006212
DomainFU

ERBB3 ERBB4

4.83e-0418342SM00261
DomainOlfact_rcpt

OR8U1 OR8B4 OR11H2 OR1L1 OR8U8

6.77e-04393345IPR000725
Domain7TM_GPCR_Srsx

ADRA1D SSTR1 CNR2

1.10e-03112343SM01381
DomainTyrKc

ERBB3 ERBB4

1.12e-0288342SM00219
DomainTyr_kinase_cat_dom

ERBB3 ERBB4

1.12e-0288342IPR020635
DomainPROTEIN_KINASE_TYR

ERBB3 ERBB4

1.34e-0297342PS00109
DomainTyr_kinase_AS

ERBB3 ERBB4

1.34e-0297342IPR008266
DomainPkinase_Tyr

ERBB3 ERBB4

2.30e-02129342PF07714
PathwayREACTOME_OLFACTORY_SIGNALING_PATHWAY

OR8U1 OR8B4 OR11H2 CNGA4 OR1L1 OR8U8 OR4E1

1.67e-05417297M4072
PathwayREACTOME_SENSORY_PERCEPTION

TAS2R16 OR8U1 OR8B4 OR11H2 CNGA4 OR1L1 OR8U8 OR4E1

3.03e-05636298M41834
PathwayREACTOME_ERBB2_ACTIVATES_PTK6_SIGNALING

ERBB3 ERBB4

2.22e-0411292MM15478
PathwayREACTOME_ERBB2_REGULATES_CELL_MOTILITY

ERBB3 ERBB4

3.14e-0413292MM15320
PathwayREACTOME_ERBB2_ACTIVATES_PTK6_SIGNALING

ERBB3 ERBB4

3.14e-0413292M27729
PathwayREACTOME_PI3K_EVENTS_IN_ERBB2_SIGNALING

ERBB3 ERBB4

3.66e-0414292MM14761
PathwayREACTOME_SHC1_EVENTS_IN_ERBB2_SIGNALING

ERBB3 ERBB4

3.66e-0414292MM14531
PathwayREACTOME_COPII_MEDIATED_VESICLE_TRANSPORT

TRAPPC10 GOSR2 SEC23A

3.74e-0469293M27113
PathwayPID_ERBB_NETWORK_PATHWAY

ERBB3 ERBB4

4.22e-0415292M201
PathwayREACTOME_ERBB2_REGULATES_CELL_MOTILITY

ERBB3 ERBB4

4.22e-0415292M27608
PathwayKEGG_CALCIUM_SIGNALING_PATHWAY

SLC8A2 ERBB3 ERBB4 ADRA1D

4.56e-04178294M2890
PathwayREACTOME_PI3K_EVENTS_IN_ERBB2_SIGNALING

ERBB3 ERBB4

4.82e-0416292M570
PathwayWP_GPCRS_CLASS_A_RHODOPSINLIKE

ADRA1D OR8B4 SSTR1 CNR2

5.38e-04186294MM15994
PathwayREACTOME_COPII_MEDIATED_VESICLE_TRANSPORT

TRAPPC10 GOSR2 SEC23A

6.44e-0483293MM14819
PathwayREACTOME_SHC1_EVENTS_IN_ERBB2_SIGNALING

ERBB3 ERBB4

9.20e-0422292M26929
PathwayBIOCARTA_HER2_PATHWAY

ERBB3 ERBB4

1.01e-0323292MM1480
PathwayBIOCARTA_HER2_PATHWAY

ERBB3 ERBB4

1.01e-0323292M18719
PathwayKEGG_OLFACTORY_TRANSDUCTION

OR8U1 OR8B4 CNGA4 OR1L1 OR8U8

1.07e-03389295M14091
PathwayKEGG_MEDICUS_REFERENCE_REGULATION_OF_GF_RTK_RAS_ERK_SIGNALING_UBIQUITINATION_OF_RTK_BY_CBL

ERBB3 ERBB4

1.19e-0325292M47934
PathwayREACTOME_SIGNALING_BY_ERBB2_IN_CANCER

ERBB3 ERBB4

1.29e-0326292M29535
PathwayREACTOME_DOWNREGULATION_OF_ERBB2_SIGNALING

ERBB3 ERBB4

1.29e-0326292MM15501
PathwayREACTOME_DOWNREGULATION_OF_ERBB2_SIGNALING

ERBB3 ERBB4

1.60e-0329292M27756
PathwayWP_GPCRS_NONODORANT

TAS2R16 ADRA1D SSTR1 CNR2

2.03e-03266294MM15843
PathwayWP_MAMMARY_GLAND_DEVELOPMENT_PREGNANCY_AND_LACTATION_STAGE_3_OF_4

ERBB3 ERBB4

2.07e-0333292M39455
PathwayREACTOME_CARGO_CONCENTRATION_IN_THE_ER

GOSR2 SEC23A

2.07e-0333292M27591
PathwayREACTOME_SIGNALING_BY_ERBB4

ERBB3 ERBB4

2.07e-0333292MM14523
PathwayREACTOME_CARGO_CONCENTRATION_IN_THE_ER

GOSR2 SEC23A

2.47e-0336292MM15300
PathwayREACTOME_SIGNALING_BY_ERBB2

ERBB3 ERBB4

3.66e-0344292MM14520
PathwayREACTOME_ER_TO_GOLGI_ANTEROGRADE_TRANSPORT

TRAPPC10 GOSR2 SEC23A

3.93e-03156293M27097
PathwayWP_ERBB_SIGNALING_PATHWAY

ERBB3 ERBB4

4.00e-0346292MM15950
PathwayREACTOME_SIGNALING_BY_PTK6

ERBB3 ERBB4

4.35e-0348292MM15479
PathwayREACTOME_SIGNALING_BY_ERBB2

ERBB3 ERBB4

4.71e-0350292M553
PathwayREACTOME_ER_TO_GOLGI_ANTEROGRADE_TRANSPORT

TRAPPC10 GOSR2 SEC23A

4.84e-03168293MM14785
PathwayREACTOME_SIGNALING_BY_PTK6

ERBB3 ERBB4

5.47e-0354292M29742
PathwayKEGG_MEDICUS_REFERENCE_RTK_PLCG_ITPR_SIGNALING_PATHWAY

ERBB3 ERBB4

5.67e-0355292M47952
Pubmed

The upgraded role of HER3 and HER4 receptors in breast cancer.

ERBB3 ERBB4

1.04e-06236219481955
Pubmed

Cytogenetic analysis of HER1/EGFR, HER2, HER3 and HER4 in 278 breast cancer patients.

ERBB3 ERBB4

1.04e-06236218182100
Pubmed

Prognostic significance of serum ERBB3 and ERBB4 mRNA in lung adenocarcinoma patients.

ERBB3 ERBB4

1.04e-06236226254096
Pubmed

4-Phenybutyric acid promotes gastric cancer cell migration via histone deacetylase inhibition-mediated HER3/HER4 up-regulation.

ERBB3 ERBB4

1.04e-06236228851073
Pubmed

HER3, but Not HER4, Plays an Essential Role in the Clinicopathology and Prognosis of Gastric Cancer: A Meta-Analysis.

ERBB3 ERBB4

1.04e-06236227536774
Pubmed

Quantitative Phosphoproteomics Analysis of ERBB3/ERBB4 Signaling.

ERBB3 ERBB4

1.04e-06236226745281
Pubmed

[Expression and significance of ErbB3 and ErbB4 in patients with laryngeal squamous cell carcinomas].

ERBB3 ERBB4

1.04e-06236217969526
Pubmed

ErbB family immunohistochemical expression in colorectal cancer patients with higher risk of recurrence after radical surgery.

ERBB3 ERBB4

1.04e-06236219390858
Pubmed

HER3 and HER4 are highly expressed in human meningiomas.

ERBB3 ERBB4

1.04e-06236231400925
Pubmed

The developmental transcription factor IRF6 attenuates ABCG2 gene expression and distinctively reverses stemness phenotype in nasopharyngeal carcinoma.

IRF6 ABCG2

1.04e-06236229111349
Pubmed

Specific antibodies and sensitive immunoassays for the human epidermal growth factor receptors (HER2, HER3, and HER4).

ERBB3 ERBB4

3.12e-06336228653892
Pubmed

Expression of ErbB3, ErbB4, and neuregulin-1 mRNA during tooth development.

ERBB3 ERBB4

3.12e-06336212112465
Pubmed

Analysis of Grb7 recruitment by heregulin-activated erbB receptors reveals a novel target selectivity for erbB3.

ERBB3 ERBB4

3.12e-0633629516479
Pubmed

The ErbB3 receptor tyrosine kinase negatively regulates Paneth cells by PI3K-dependent suppression of Atoh1.

ERBB3 ERBB4

3.12e-06336228304405
Pubmed

Binding interaction of the heregulinbeta egf domain with ErbB3 and ErbB4 receptors assessed by alanine scanning mutagenesis.

ERBB3 ERBB4

3.12e-0633629565587
Pubmed

ErbB receptor signaling directly controls oligodendrocyte progenitor cell transformation and spontaneous remyelination after spinal cord injury.

ERBB3 ERBB4

3.12e-06336230637799
Pubmed

An RBCC protein implicated in maintenance of steady-state neuregulin receptor levels.

ERBB3 ERBB4

3.12e-06336211867753
Pubmed

Dynamically varying interactions between heregulin and ErbB proteins detected by single-molecule analysis in living cells.

ERBB3 ERBB4

3.12e-06336222891299
Pubmed

Evaluation of type 1 growth factor receptor family expression in benign and malignant thyroid lesions.

ERBB3 ERBB4

3.12e-06336218424286
Pubmed

Characterization of a breast cancer cell differentiation factor that specifically activates the HER4/p180erbB4 receptor.

ERBB3 ERBB4

3.12e-0633627689552
Pubmed

Expression and significance of HER family receptors in neuroblastic tumors.

ERBB3 ERBB4

3.12e-06336221203803
Pubmed

Protein expression of HER2, 3, 4 in gastric cancer: correlation with clinical features and survival.

ERBB3 ERBB4

3.12e-06336225731189
Pubmed

erbB genes in the mouse uterus: cell-specific signaling by epidermal growth factor (EGF) family of growth factors during implantation.

ERBB3 ERBB4

3.12e-0633629851845
Pubmed

ErbB receptor tyrosine kinase family expression levels in urothelial bladder carcinoma.

ERBB3 ERBB4

3.12e-06336223333248
Pubmed

Expression and potential role of ErbB receptors in type II endometrial cancer.

ERBB3 ERBB4

3.12e-06336223395558
Pubmed

High incidence of ErbB3, ErbB4, and MET expression in ovarian cancer.

ERBB3 ERBB4

3.12e-06336224901400
Pubmed

The relation between survival and expression of HER1 and HER2 depends on the expression of HER3 and HER4: a study in bladder cancer patients.

ERBB3 ERBB4

6.24e-06436216685269
Pubmed

Characterisation of HER heterodimers in breast cancer using in situ proximity ligation assay.

ERBB3 ERBB4

6.24e-06436224557338
Pubmed

Analysis of ErbB receptors in pulmonary carcinoid tumors.

ERBB3 ERBB4

6.24e-06436219447869
Pubmed

HER2 phosphorylation is maintained by a PKB negative feedback loop in response to anti-HER2 herceptin in breast cancer.

ERBB3 ERBB4

6.24e-06436221203579
Pubmed

Laminin-1 and epidermal growth factor family members co-stimulate fetal pancreas cell proliferation and colony formation.

ERBB3 ERBB4

6.24e-06436215733067
Pubmed

Inverse regulation of EGFR/HER1 and HER2-4 in normal and malignant human breast tissue.

ERBB3 ERBB4

6.24e-06436223991224
Pubmed

Evaluation of the prognostic and predictive value of HER family mRNA expression in high-risk early breast cancer: a Hellenic Cooperative Oncology Group (HeCOG) study.

ERBB3 ERBB4

6.24e-06436218985033
Pubmed

Neuregulin signaling regulates neural precursor growth and the generation of oligodendrocytes in vitro.

ERBB3 ERBB4

6.24e-06436211425901
Pubmed

HER Family Protein Expression in a Greek Population with Gastric Cancer. A Retrospective Hellenic Cooperative Oncology Group Study.

ERBB3 ERBB4

6.24e-06436227069134
Pubmed

[Neuregulin-1 promotes proliferation and migration of human coronary artery smooth muscle cells by enhancing its receptor phosphorylation].

ERBB3 ERBB4

6.24e-06436226648299
Pubmed

Expression of heregulin, phosphorylated HER-2, HER-3 and HER-4 in HER-2 negative breast cancers.

ERBB3 ERBB4

6.24e-06436219148499
Pubmed

A hierarchical network of interreceptor interactions determines signal transduction by Neu differentiation factor/neuregulin and epidermal growth factor.

ERBB3 ERBB4

6.24e-0643628816440
Pubmed

Expression of epidermal growth factors, erbBs, in the nasal mucosa of patients with chronic hypertrophic rhinitis.

ERBB3 ERBB4

6.24e-06436222327010
Pubmed

Evaluation of the prognostic significance of HER family mRNA expression in high-risk early breast cancer: a Hellenic Cooperative Oncology Group (HeCOG) validation study.

ERBB3 ERBB4

6.24e-06436226021752
Pubmed

Activated HER-receptors in predicting outcome of ER-positive breast cancer patients treated with adjuvant endocrine therapy.

ERBB3 ERBB4

6.24e-06436222854050
Pubmed

Epidermal growth factor receptor activation in glioblastoma through novel missense mutations in the extracellular domain.

ERBB3 ERBB4

6.24e-06436217177598
Pubmed

Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases.

ERBB3 ERBB4

6.24e-0643629168115
Pubmed

The erbB/HER type 1 tyrosine kinase receptor family.

ERBB3 ERBB4

6.24e-0643629771475
Pubmed

Expression of the HER-1-4 family of receptor tyrosine kinases in neuroendocrine tumours.

ERBB3 ERBB4

6.24e-06436220204273
Pubmed

Localization of phosphorylated ErbB1-4 and heregulin in colorectal cancer.

ERBB3 ERBB4

1.04e-05536225416285
Pubmed

An activated ErbB3/NRG1 autocrine loop supports in vivo proliferation in ovarian cancer cells.

ERBB3 ERBB4

1.04e-05536220227043
Pubmed

Synapse-associated expression of an acetylcholine receptor-inducing protein, ARIA/heregulin, and its putative receptors, ErbB2 and ErbB3, in developing mammalian muscle.

ERBB3 ERBB4

1.04e-0553627589796
Pubmed

Heregulin (HRG)-induced mitogenic signaling and cytotoxic activity of a HRG/PE40 ligand toxin in human breast cancer cells.

ERBB3 ERBB4

1.04e-0553629019162
Pubmed

Tissue interaction mediated by neuregulin-1 and ErbB receptors regulates epithelial morphogenesis of mouse embryonic submandibular gland.

ERBB3 ERBB4

1.04e-05536215254894
Pubmed

Leucine-rich repeat and immunoglobulin domain-containing protein-1 (Lrig1) negative regulatory action toward ErbB receptor tyrosine kinases is opposed by leucine-rich repeat and immunoglobulin domain-containing protein 3 (Lrig3).

ERBB3 ERBB4

1.04e-05536223723069
Pubmed

Gene expression pattern of the epidermal growth factor receptor family and LRIG1 in renal cell carcinoma.

ERBB3 ERBB4

1.04e-05536222554477
Pubmed

Developmental profile of ErbB receptors in murine central nervous system: implications for functional interactions.

ERBB3 ERBB4

1.04e-05536215682390
Pubmed

Neuregulin-1 induces branching morphogenesis in the developing lung through a P13K signal pathway.

ERBB3 ERBB4

1.04e-05536215524405
Pubmed

Dominance of ErbB-1 heterodimers in lung epithelial cells overexpressing ErbB-2. Both ErbB-1 and ErbB-2 contribute significantly to tumorigenicity.

ERBB3 ERBB4

1.04e-05536210572067
Pubmed

Heregulin targets gamma-catenin to the nucleolus by a mechanism dependent on the DF3/MUC1 oncoprotein.

ERBB3 ERBB4

1.04e-05536212939402
Pubmed

Hepatitis C Virus Activates a Neuregulin-Driven Circuit to Modify Surface Expression of Growth Factor Receptors of the ErbB Family.

ERBB3 ERBB4

1.04e-05536226886748
Pubmed

Segregation of receptor and ligand regulates activation of epithelial growth factor receptor.

ERBB3 ERBB4

1.04e-05536212646923
Pubmed

Expression of epidermal growth factors and a tight junction protein in the nasal mucosa of patients with chronic hypertrophic rhinitis.

ERBB3 ERBB4

1.04e-05536223137868
Pubmed

Alternative HER/PTEN/Akt pathway activation in HPV positive and negative penile carcinomas.

ERBB3 ERBB4

1.04e-05536221407808
Pubmed

Neuregulins with an Ig-like domain are essential for mouse myocardial and neuronal development.

ERBB3 ERBB4

1.04e-0553628643489
Pubmed

Isoform-specific expression and function of neuregulin.

ERBB3 ERBB4

1.04e-0553629342050
Pubmed

Ligands for ErbB-family receptors encoded by a neuregulin-like gene.

ERBB3 ERBB4

1.04e-0553629168114
Pubmed

Wnt and Neuregulin1/ErbB signalling extends 3D culture of hormone responsive mammary organoids.

ERBB3 ERBB4

1.56e-05636227782124
Pubmed

Transgenic MUC1 interacts with epidermal growth factor receptor and correlates with mitogen-activated protein kinase activation in the mouse mammary gland.

ERBB3 ERBB4

1.56e-05636211278868
Pubmed

Myocilin mediates myelination in the peripheral nervous system through ErbB2/3 signaling.

ERBB3 GLDN

1.56e-05636223897819
Pubmed

Neuroglycan C, a novel member of the neuregulin family.

ERBB3 ERBB4

1.56e-05636215358134
Pubmed

Modulation of Erbb2 signaling during development: a threshold level of Erbb2 signaling is required for development.

ERBB3 ERBB4

1.56e-05636215496447
Pubmed

LRIG1 restricts growth factor signaling by enhancing receptor ubiquitylation and degradation.

ERBB3 ERBB4

1.56e-05636215282549
Pubmed

The S100A4 Protein Signals through the ErbB4 Receptor to Promote Neuronal Survival.

ERBB3 ERBB4

1.56e-05636230083275
Pubmed

Endocrine resistance associated with activated ErbB system in breast cancer cells is reversed by inhibiting MAPK or PI3K/Akt signaling pathways.

ERBB3 ERBB4

2.18e-05736219609946
Pubmed

Vertebrate Lrig3-ErbB interactions occur in vitro but are unlikely to play a role in Lrig3-dependent inner ear morphogenesis.

ERBB3 ERBB4

2.18e-05736220126551
Pubmed

Neuregulin-1/ErbB4 signaling controls the migration of oligodendrocyte precursor cells during development.

ERBB3 ERBB4

2.18e-05736222504067
Pubmed

A comprehensive study of the association between the EGFR and ERBB2 genes and glioma risk.

ERBB3 ERBB4

2.18e-05736220446891
Pubmed

Multiple essential functions of neuregulin in development.

ERBB3 ERBB4

2.18e-0573627477375
Pubmed

Stretch-induced fetal type II cell differentiation is mediated via ErbB1-ErbB4 interactions.

ERBB3 ERBB4

2.18e-05736222493501
Pubmed

Embryo-uterine interactions via the neuregulin family of growth factors during implantation in the mouse.

ERBB3 ERBB4

2.91e-05836215306553
Pubmed

Differential expression of neuregulins and their receptors in the olfactory bulb layers of the developing mouse.

ERBB3 ERBB4

2.91e-05836216488402
Pubmed

Dynamic expression of Erbb pathway members during early mammary gland morphogenesis.

ERBB3 ERBB4

2.91e-05836217960183
Pubmed

ERBB3-dependent AKT and ERK pathways are essential for atrioventricular cushion development in mouse embryos.

ERBB3 ERBB4

3.73e-05936234714866
Pubmed

Defects in pathfinding by cranial neural crest cells in mice lacking the neuregulin receptor ErbB4.

ERBB3 ERBB4

3.73e-05936210655590
Pubmed

EGFR Ligands Differentially Stabilize Receptor Dimers to Specify Signaling Kinetics.

ERBB3 ERBB4

3.73e-05936228988771
Pubmed

Somatic mutations in epidermal growth factor receptor signaling pathway genes in non-small cell lung cancers.

ERBB3 ERBB4

4.66e-051036220881644
Pubmed

The epidermal growth factor receptor couples transforming growth factor-alpha, heparin-binding epidermal growth factor-like factor, and amphiregulin to Neu, ErbB-3, and ErbB-4.

ERBB3 ERBB4

4.66e-05103628702723
Pubmed

In situ hybridization reveals developmental regulation of ErbB1-4 mRNA expression in mouse midbrain: implication of ErbB receptors for dopaminergic neurons.

ERBB3 ERBB4

4.66e-051036219298847
Pubmed

Structural basis of cargo membrane protein discrimination by the human COPII coat machinery.

GOSR2 SEC23A

4.66e-051036218843296
Pubmed

Evidence for new homotypic and heterotypic interactions between transmembrane helices of proteins involved in receptor tyrosine kinase and neuropilin signaling.

ERBB3 ERBB4

5.70e-051136225315821
Pubmed

Impaired migration and delayed differentiation of pancreatic islet cells in mice lacking EGF-receptors.

ERBB3 ERBB4

5.70e-051136210821760
Pubmed

Altered trophoblast proliferation is insufficient to account for placental dysfunction in Egfr null embryos.

ERBB3 ERBB4

5.70e-051136217822758
Pubmed

Cysteine-rich domain isoforms of the neuregulin-1 gene are required for maintenance of peripheral synapses.

ERBB3 ERBB4

8.07e-051336210707974
Pubmed

An EGFR-ERK-SOX9 signaling cascade links urothelial development and regeneration to cancer.

ERBB3 ERBB4

8.07e-051336221512138
Pubmed

Regulation of epidermal growth factor receptor trafficking by lysine deacetylase HDAC6.

ERBB3 ERBB4 SPCS2

8.84e-058336320029029
Pubmed

Neuregulin-1/ErbB signaling serves distinct functions in myelination of the peripheral and central nervous system.

ERBB3 ERBB4

1.08e-041536218760695
Pubmed

Cdk5 phosphorylation of ErbB4 is required for tangential migration of cortical interneurons.

ERBB3 ERBB4

1.24e-041636224142862
Pubmed

Chromosomal location-dependent nonstochastic onset of odor receptor expression.

OR8B4 OR4E1

1.40e-041736220668191
Pubmed

Fibulin-1 is required during cardiac ventricular morphogenesis for versican cleavage, suppression of ErbB2 and Erk1/2 activation, and to attenuate trabecular cardiomyocyte proliferation.

ERBB3 ERBB4

1.40e-041736222183742
Pubmed

Jun and JunD-dependent functions in cell proliferation and stress response.

ERBB3 ERBB4

1.40e-041736220300111
Pubmed

Phosphotyrosine interactome of the ErbB-receptor kinase family.

ERBB3 ERBB4

1.76e-041936216729043
Pubmed

Notch signaling is essential for ventricular chamber development.

ERBB3 ERBB4

3.60e-042736217336907
Pubmed

Lrp4 and Wise interplay controls the formation and patterning of mammary and other skin appendage placodes by modulating Wnt signaling.

ERBB3 ERBB4

5.72e-043436223293290
InteractionNPC1 interactions

ATP11C ABCG2 CNGA4 SEC23A TM9SF3 SPCS2

8.97e-06364286int:NPC1
InteractionNRN1 interactions

ATP11C RPRM SPCS2

2.29e-0540283int:NRN1
InteractionTMEM230 interactions

ATP11C ERBB3 ERBB4

3.50e-0546283int:TMEM230
InteractionBTN2A3P interactions

SPCS2 BTN2A3P

3.89e-057282int:BTN2A3P
InteractionNRG2 interactions

ERBB3 ERBB4

3.89e-057282int:NRG2
InteractionSELENOK interactions

ERBB3 ERBB4 CNR2

5.37e-0553283int:SELENOK
InteractionMUC4 interactions

ERBB3 ERBB4

6.66e-059282int:MUC4
InteractionPTPN20 interactions

ERBB3 ERBB4

1.68e-0414282int:PTPN20
InteractionSMIM20 interactions

ERBB3 ERBB4

1.68e-0414282int:SMIM20
InteractionTMEM134 interactions

ERBB3 ERBB4

2.50e-0417282int:TMEM134
InteractionSHD interactions

ERBB3 ERBB4

2.81e-0418282int:SHD
InteractionFATE1 interactions

RPRM GOSR2 SEC23A

3.55e-04100283int:FATE1
InteractionSHC4 interactions

ERBB3 ERBB4

4.23e-0422282int:SHC4
InteractionCLEC17A interactions

RPRM SEC23A

4.63e-0423282int:CLEC17A
InteractionGPR42 interactions

RPRM GOSR2 PAEP

4.82e-04111283int:GPR42
InteractionDUSP18 interactions

ERBB3 ERBB4

5.04e-0424282int:DUSP18
InteractionSLA2 interactions

ERBB3 ERBB4

5.04e-0424282int:SLA2
InteractionSOCS5 interactions

ERBB3 ERBB4

5.04e-0424282int:SOCS5
InteractionSH2B3 interactions

ERBB3 ERBB4

5.48e-0425282int:SH2B3
InteractionHSH2D interactions

ERBB3 ERBB4

5.48e-0425282int:HSH2D
InteractionCRTAC1 interactions

TRAPPC10 TXNDC16

6.39e-0427282int:CRTAC1
InteractionZNF532 interactions

ERBB3 ERBB4

6.39e-0427282int:ZNF532
InteractionSTAP1 interactions

ERBB3 ERBB4

6.39e-0427282int:STAP1
InteractionSLA interactions

ERBB3 ERBB4

7.38e-0429282int:SLA
Cytoband15q21.2

GLDN SPPL2A

2.40e-042936215q21.2
CytobandEnsembl 112 genes in cytogenetic band chr14q21

SSTR1 SEC23A

2.66e-0397362chr14q21
GeneFamilyErb-b2 receptor tyrosine kinases

ERBB3 ERBB4

1.29e-0542721096
GeneFamilyOlfactory receptors, family 8

OR8U1 OR8B4 OR8U8

5.23e-0549273155
ToppCellPosterior_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

ERBB4 CACNG5 GLDN GPR176

6.53e-06155354105d59d8a1bb8cb37eef2c1767d737b2108ac7c5
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Crispld2_Kcne4|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ERBB4 CACNG5 CLSTN2 GPR176

7.59e-06161354be77e99faf653480c166305df3a4e93db76f0dcb
ToppCellBAL-Severe-cDC_8|Severe / Compartment, Disease Groups and Clusters

TXNDC16 SLC8A2 ABCG2 GPR176

8.16e-06164354e8cbe7e01eca32886eb44e02d5333056b6bebc50
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CACNG5 CLSTN2 RPRM DNAH6

1.01e-05173354ee972d9cc68755926512fd3bbe1267098c67cd94
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_RPL31P31|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

NIPAL2 CLSTN2 RPRM DNAH6

1.18e-05180354b7513b9816a9cb9f3caaddb2a9fed0be1c7f9805
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

NIPAL2 CLSTN2 RPRM DNAH6

1.18e-05180354f96c5be4705e3d338c0393d2885ac8d5beccd6fd
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-5_VIP_TOX2|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ERBB4 ADRA1D CACNG5 RPRM

1.20e-0518135435bcdcd2651149692e5b150e887c0f450c81d2d4
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_RPL31P31|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

NIPAL2 CLSTN2 RPRM DNAH6

1.26e-051833543ebe334ad570e3525341badb558f369c61daf3d3
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1_LAMP5_NDNF|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ATP11C ERBB4 ADRA1D SSTR1

1.34e-05186354310d16f4e5cffee3ea6d7635508c513a3b92131e
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1_LAMP5_NDNF|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CTXND1 ATP11C ERBB4 ADRA1D

1.40e-05188354433a25fe52914e07e7ba695881f9bcca2d9467ff
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1_LAMP5_NDNF|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ATP11C ERBB4 ADRA1D SSTR1

1.43e-05189354f0aaf2994d319a39877d2845eaab9f166adead4e
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CTXND1 ATP11C ERBB4 ADRA1D

1.46e-0519035456cc761e50fddfb5366391518b4d8e16589b6b42
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_1|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CTXND1 ATP11C ERBB4 ADRA1D

1.46e-0519035425d4b591f75c26e404a34c42f1742d580af6598d
ToppCell3'-Pediatric_IBD-SmallIntestine-Epithelial-goblet|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ANO7 IRF6 ERBB3 TM9SF3

1.61e-05195354c5f33b420c9ac14dc67fea632b8c2bc2442cbf3d
ToppCell3'-Pediatric_IBD-SmallIntestine-Epithelial-goblet-Goblet_cell|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ANO7 IRF6 ERBB3 TM9SF3

1.61e-05195354219c5d0cde7f6082755154f54db221413ec555cb
ToppCellNeuronal-Inhibitory-iA-iA_1(SST_PAX6)-NMBR-|Neuronal / cells hierarchy compared to all cells using T-Statistic

CTXND1 ATP11C ERBB4 ADRA1D

1.78e-05200354d416a7be1a4e6232fb58a9687774da24821f1fdd
ToppCellNeuronal-Inhibitory-iA-iA_1(SST_PAX6)-NMBR|Neuronal / cells hierarchy compared to all cells using T-Statistic

CTXND1 ATP11C ERBB4 ADRA1D

1.78e-05200354862db57d043bdf3cb059fbfc8b29bc1eafdf64ec
ToppCellNeuronal-Excitatory-eB(RORB)|Neuronal / cells hierarchy compared to all cells using T-Statistic

CACNG5 CLSTN2 RPRM DNAH6

1.78e-0520035451265e30f1138fd79733001d0db759f3dab0aaeb
ToppCellNeuronal-Inhibitory-iA-iA_1(SST_PAX6)-NMBR--L1|Neuronal / cells hierarchy compared to all cells using T-Statistic

CTXND1 ATP11C ERBB4 ADRA1D

1.78e-05200354a91345f268f13170c27309333603eb82400c9947
ToppCellLPS-IL1RA+antiTNF-Unknown-Endothelial-Pericyte_2|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ADRA1D DNAH6 PAEP

1.76e-041393532fb51abb3ce88c21726c026d6365b2582e2e79f6
ToppCellPosterior_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Synpr|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

ERBB4 GLDN GPR176

1.95e-0414435304f9054895be2275eecda687a6eeb02fa5ec69b9
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-Degenerative_Endothelial_Cell-Degenerative_Peritubular_Capilary_Endothelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ANO7 SLC8A2 RPRM

2.07e-04147353c8e5bdc3538089acd35a4b41390afaec0ac6d1aa
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Lmo1_Fam159b|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ERBB4 CACNG5 RPRM

2.11e-041483539205b26e0d042b342cc643cda0f4f3f8bb392d00
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Lmo1_Fam159b|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ERBB4 CACNG5 RPRM

2.16e-0414935398ae408d2d0347865875ff8bbd89d359decea526
ToppCellPND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_G2M|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NIPAL2 CTXND1 IRF6

2.42e-041553538e239470799426ea474a36f57e1b7e0d9365ca5f
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Crispld2_Kcne4|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ERBB4 CLSTN2 GPR176

2.47e-04156353896e2d958be0a5c62fb6eebad2dfb7e1ce69f3ad
ToppCellBAL-Severe-Myeloid-cDC-cDC-cDC_8|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

TXNDC16 SLC8A2 GPR176

2.71e-041613537e0b8119cea208c0b4a0dffdf94ff6137d0b4c90
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Pygm_C1ql1|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ERBB4 CACNG5 CLSTN2

2.71e-041613533b5d7a3dab479c6959a428f3954dedd989900276
ToppCellBAL-Severe-Myeloid-cDC-cDC-cDC_8|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TXNDC16 SLC8A2 GPR176

2.76e-041623532fd6e8f48b48d509a7533cec2f79089513c34a2f
ToppCellPosterior_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

SLC8A2 CLSTN2 RPRM

2.81e-04163353218b9ba099cb27aa91c6b73bf89b44895f5dddc3
ToppCellfacs-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l32-30|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CTXND1 ERBB3 CACNG5

2.86e-041643533caf4cdaa0164907893fea61e251fd8b5fa926e4
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Crispld2_Htr2c|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ERBB4 CACNG5 CLSTN2

2.91e-04165353c6b23013d77fa9aa967b76e451c8e42b0a657c30
ToppCellSubstantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Th|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

ANO7 CLSTN2 GLDN

2.96e-041663536a6ed5c7a43fee9a8a9be42dfa99303815b8e8ef
ToppCellLA-16._Neuronal|LA / Chamber and Cluster_Paper

CTXND1 ERBB3 GLDN

3.07e-04168353c55bbfbde8bb954f1cb9af82007bdd1f8070fee3
ToppCellPCW_05-06-Neuronal-Neuronal_SCP-neuro_proliferating_SCP3_(1)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

CTXND1 ERBB3 ERBB4

3.12e-04169353d9c3b22f62b882b8a2ea6fd9cf7afbe6d1775745
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_LCN15|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CACNG5 CLSTN2 DNAH6

3.23e-041713539e00c8191ca9d52151a49baf39f8581cb176fb76
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1_VIP_PCDH20|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ATP11C ERBB4 ADRA1D

3.28e-0417235335e961c88bfe79046533396912cedf00ca81db7b
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_LCN15|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CACNG5 CLSTN2 DNAH6

3.28e-0417235392e76cbf4807704790f42cf2507e92f85cd3bc92
ToppCellfacs-Large_Intestine-Proximal-3m-Epithelial|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CTXND1 ERBB3 ABCG2

3.34e-04173353e1378201b15ffb98e196ac39fe3ee4b4078953bd
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_LCN15|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CACNG5 CLSTN2 DNAH6

3.34e-041733535aa4d45a01d2d09eff8b4deb32bd91ab2471210a
ToppCellfacs-Large_Intestine-Proximal-3m|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CTXND1 ERBB3 ABCG2

3.34e-0417335399532bb768ee35fed939a377acb5215d3f8904bd
ToppCell5'-GW_trimst-1.5-LargeIntestine-Neuronal-Glial_immature-Glia_1_(DHH+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CTXND1 ERBB3 CLSTN2

3.34e-04173353789ab8b2709f4b8728e3733bc72744e9d92ea5ea
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_LCN15|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CACNG5 CLSTN2 DNAH6

3.40e-041743532947e5906b172d149412fa4e77476fce4ea695d2
ToppCellmetastatic_Brain-Endothelial_cells-Stalk-like_ECs|Endothelial_cells / Location, Cell class and cell subclass

ANO7 IRF6 GPR176

3.45e-04175353f6a6db992e803d36c866a91706b02f67e0fd3e09
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

NIPAL2 CLSTN2 DNAH6

3.45e-0417535306af6629766e2054e6995e8cdb3907658fec49d3
ToppCell5'-GW_trimst-1.5-LargeIntestine-Epithelial-epithelial_progenitor_cell-TA|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CTXND1 IRF6 ERBB3

3.51e-04176353e7502a345b2da83a9a60f50cf78f1aef385c99df
ToppCellfacs-Lung-24m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l25-31|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TXNDC16 CTXND1 ERBB3

3.57e-041773536b4fe717928814dafcd13090b1c90ea973938c6d
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1-3_VIP_SSTR1|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CTXND1 ERBB4 SSTR1

3.57e-04177353fdab7b7ddfb06f913b8224c0c80574dc3cf4cbd4
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6-Exc_L6_THEMIS_LINC00343|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SLC8A2 CLSTN2 DNAH6

3.57e-04177353921783ed0fe20294d2f384d9136924b679df01bb
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CLSTN2 RPRM DNAH6

3.57e-041773537e799333307448c6a94d1f33dbc59c543336f45e
ToppCellPCW_05-06-Neuronal-Neuronal_SCP-neuro_pre_proliferating_SCP_(4)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

CTXND1 ERBB3 ERBB4

3.57e-0417735359726bfd98f656fdcedf448a7e2e76a9bfad8285
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_FAM95C|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SLC8A2 CLSTN2 RPRM

3.63e-04178353431e7557b8e8764e16e9e48368ce6bfa3c61561a
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CLSTN2 RPRM DNAH6

3.63e-04178353a48739a588f361b4bc69405d7e256c11f61cf43c
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_RPL31P31|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CLSTN2 RPRM DNAH6

3.69e-04179353b35a7f8115c997c390201da01d7cb10b10769aec
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Macroglial-astrocyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CTXND1 CACNG5 CNR2

3.69e-041793537ae67e1c09a4ce9b3bcec4c48ee9cf2b1cb4e339
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_FAM95C|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SLC8A2 CLSTN2 RPRM

3.75e-04180353b514c55e52b46e8a1a2f09ed2c59a7683367a505
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1_LAMP5_GGT8P|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CTXND1 ATP11C ERBB4

3.81e-041813539842537f9a607d8557c43790008d175edab1f32c
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CLSTN2 SSTR1 DNAH6

3.87e-0418235331efc06d6b073e8e341648207093e5f33c6f9183
ToppCellPCW_05-06-Neuronal-Neuronal_SCP|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

CTXND1 ERBB3 ERBB4

3.87e-04182353b4fc5e4f5d8440a3c9ee0a6fd0da87b43cabc8c6
ToppCellPCW_05-06-Neuronal-Neuronal_SCP-neuro_SCP_(0)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

CTXND1 ERBB3 ERBB4

3.94e-04183353f517215ff45dec914af52dfdbc4579c19654c3aa
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_RPL31P31|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CLSTN2 RPRM DNAH6

4.00e-041843539cc5c588f7c6631b3fb8a522214a09ca32947e72
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L5-6_LAMP5_SFTA3_(Lamp5_Lhx6_2)|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CTXND1 ATP11C ERBB4

4.00e-04184353e2de27cee3ea80f9b7a9a7884ceceeaa67b3214a
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-6_LAMP5_CA13_(Lamp5_Lhx6_1)|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CTXND1 ATP11C ERBB4

4.00e-04184353ae0a77e3e520a246b17776bb19503519636b02ee
ToppCelldroplet-Limb_Muscle-nan-3m-Macroglial-nan|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CTXND1 ERBB3 GLDN

4.06e-04185353554c5d812197fbf66bf279fcc953277e926ade15
ToppCell367C-Endothelial_cells-Endothelial-B_(Artery)-|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

IRF6 ERBB4 SSTR1

4.06e-04185353b57dae20c21f984edd2acee4344d86f033108ebf
ToppCell367C-Endothelial_cells-Endothelial-B_(Artery)|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

IRF6 ERBB4 SSTR1

4.06e-04185353d3b054d203e575c1bb5455aa7a2e551a0957a760
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-5_VIP_TOX2|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ERBB4 CACNG5 RPRM

4.06e-04185353caf4f57f2db9ff72a652c8573e16e7ab180ffc05
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_RPL31P31|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CLSTN2 RPRM DNAH6

4.06e-04185353a1b2525da018abe458908cab7268bd403ee98d92
ToppCellfacs-Heart-LA-18m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADRA1D CLSTN2 GPR176

4.13e-04186353e2ba9f3518d87a44537a57a648df17ab98fbbb39
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SLC8A2 CLSTN2 DNAH6

4.13e-0418635384ba666237c18189d7e7556bd92dd953af733c00
ToppCellControl-Epithelial-Club|World / Disease state, Lineage and Cell class

ERBB3 ERBB4 PAEP

4.13e-041863539798428691408e17ff2af2fe2d1b345f074d67e4
ToppCellfacs-Heart-LA-18m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADRA1D CLSTN2 GPR176

4.13e-04186353fda3415222f688ef5cd8de4b0b79daa2493c585f
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-6_LAMP5_CA13_(Lamp5_Lhx6_1)|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CTXND1 ATP11C ERBB4

4.13e-0418635377592a6397b44b2b59a4fc39d7224dd95343efe6
ToppCelldroplet-Heart-nan-18m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADRA1D CACNG5 GLDN

4.19e-041873532591fe1552cd10925ad1d8d1f062a057ce6bdad9
ToppCelldroplet-Heart-nan-18m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADRA1D CACNG5 GLDN

4.19e-0418735359313a47a6012b2413d7d3673bb05fb7e49fd88f
ToppCellE12.5-Epithelial-alveolar_epithelial_cell-type_I_pneumocyte|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

IRF6 ERBB3 RPRM

4.19e-04187353baff4edc1bf64e3e03864a434fa47075ff7372fd
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L5-6_LAMP5_SFTA3_(Lamp5_Lhx6_2)|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CTXND1 ATP11C ERBB4

4.26e-041883538268574584e5fb869a6cb8bbd7135cd7454a6a25
ToppCelldroplet-Limb_Muscle-Pre-Sort-18m-Macroglial-Schwann_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CTXND1 CACNG5 GLDN

4.26e-041883533b8b9161f0fdcbde302ce5b4c0bc874628211109
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1_LAMP5_NDNF|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ATP11C ERBB4 ADRA1D

4.26e-041883530501a8aa850bd2e347020abd1cac4d8075738189
ToppCellfacs-Trachea-nan-3m-Mesenchymal-smooth_muscle_cell_of_trachea|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CTXND1 ADRA1D CACNG5

4.26e-04188353794fc1d9a726945c42f7eac221eed938309b47a9
ToppCelldroplet-Limb_Muscle-Pre-Sort-18m-Macroglial|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CTXND1 CACNG5 GLDN

4.26e-04188353c2101ded71fb16b8ddbc1f883911b1ed2a533ffc
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L5-6_LAMP5_SFTA3_(Lamp5_Lhx6_2)|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CTXND1 ATP11C ERBB4

4.26e-041883534544552ebd67e9eb3e40d8511bb2b03a6e1178f8
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-6_LAMP5_CA13_(Lamp5_Lhx6_1)|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CTXND1 ATP11C ERBB4

4.26e-041883533139540a656c0436b2123ea50741ff8d00112165
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L5-6_LAMP5_SFTA3_(Lamp5_Lhx6_2)|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CTXND1 ATP11C ERBB4

4.33e-04189353222e67d3fd106c43b0cae6538dddeaa7be1f759f
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-4_LAMP5_DUSP4_(Lamp5_Rosehip)|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CTXND1 ATP11C ERBB4

4.33e-04189353979b7fa947538aa7ca4a219263da2575869a2caa
ToppCelldroplet-Kidney-nan-3m-Epithelial-Stroma____kidney_mesangial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC8A2 CLSTN2 GLDN

4.33e-04189353a959c9d6a0866582688a4204d625c1e5a123e93d
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-6_LAMP5_CA13_(Lamp5_Lhx6_1)|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CTXND1 ATP11C ERBB4

4.39e-041903532f54da2bee411f8868348a4c37034184b8f58a89
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CTXND1 ATP11C ERBB4

4.39e-041903533b8d1e66ae68c1eee64095e75195d76d97e24026
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L5-6_LAMP5_SFTA3_(Lamp5_Lhx6_2)|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CTXND1 ATP11C ERBB4

4.39e-0419035359720dfe9de1b980807644536c919d2a02ba69dd
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-4_LAMP5_DUSP4_(Lamp5_Rosehip)|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CTXND1 ATP11C ERBB4

4.39e-04190353be2b184a3559da41ba387ae0fdbeb9ae532868a5
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_1|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CTXND1 ATP11C ERBB4

4.39e-04190353dc655e4782aab274f0c9b6e36a5ce315e3a1a4b9
ToppCelldroplet-Kidney-nan-21m-Epithelial-Stroma____kidney_mesangial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC8A2 CACNG5 CLSTN2

4.39e-04190353e04f47705851563515b6a66a2634cf7a574f7bda
ToppCellPCW_07-8.5-Epithelial-Epithelial_airway-epi_proximal_secretory_(0)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

IRF6 ERBB3 ERBB4

4.46e-0419135360ff989fe99d243a3d52955223680cdd1f1917a4
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1_LAMP5_NDNF|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ATP11C ERBB4 ADRA1D

4.46e-04191353fa50a3c7ff86e1ee07100da1ace0b0fa1b0ab26b
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1_LAMP5_NDNF|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ATP11C ERBB4 ADRA1D

4.46e-041913537b386512284dfaa0e95358b28ee82632ee965e64
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-4_LAMP5_DUSP4_(Lamp5_Rosehip)|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CTXND1 ATP11C ERBB4

4.53e-04192353bd3fa6c8fcb618db64d11f25cabaf08608957c35
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CTXND1 ATP11C ERBB4

4.53e-04192353f6ec683b2133b3095a1fcc06ca8605cf38f774b5
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_1|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CTXND1 ATP11C ERBB4

4.53e-04192353690b3d17c481159bc96b8bc7f6a66b51343ee858
ToppCellControl-Epithelial-Club|Control / Disease state, Lineage and Cell class

ERBB3 ERBB4 PAEP

4.53e-04192353d84ed1ea4a03edaa18c804f75afb03bd7b1f0e16
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-4_LAMP5_DUSP4_(Lamp5_Rosehip)|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CTXND1 ATP11C ERBB4

4.53e-0419235363d1b3efe93e5ff939278ebe40bacb38218ea09b
Drug4-anilinoquinazoline

ERBB3 ERBB4 ABCG2

1.53e-0616333CID000324081
DrugN1-aminopropylagmatine

ERBB3 ERBB4 SSTR1

4.19e-0622333CID000541551
DrugPD168393

ERBB3 ERBB4

1.22e-054332CID000004708
DrugRG 14921

ERBB3 ERBB4

2.03e-055332CID000197517
Drug6-quinolinecarbaldehyde

ERBB3 ERBB4

2.03e-055332CID000765653
DrugSnCe6

ERBB3 ERBB4

3.04e-056332CID000164259
DrugCochliobolic acid

ERBB3 ERBB4

3.04e-056332CID006450172
Drugdiethyl ester

ERBB3 ERBB4

3.04e-056332CID000264327
DrugSSFSB

ERBB3 ERBB4

4.26e-057332CID003035734
DrugRG 14467

ERBB3 ERBB4

4.26e-057332CID000132069
DrugD07907

ERBB3 ERBB4 ABCG2

5.84e-0552333CID011954378
DrugCI-1033

ERBB3 ERBB4 ABCG2

6.19e-0553333CID000156413
Drugindole-3-carbinol

ERBB3 ERBB4 ABCG2 GPR176

7.07e-05154334CID000003712
DrugPC9

ERBB3 ERBB4 ABCG2

8.53e-0559333CID016040245
Drug6-(methylamino)pyrido(3,4-d)pyrimidine

ERBB3 ERBB4

9.10e-0510332ctd:C107875
DrugH 661

ERBB3 ERBB4

9.10e-0510332CID003056529
DrugBE-23372M

ERBB3 ERBB4

1.11e-0411332CID005311105
Drug4,5-dianilinophthalimide

ERBB3 ERBB4

1.11e-0411332CID000001697
Drug2nq6

ERBB3 ERBB4

1.57e-0413332CID011809364
DrugHymecromone [90-33-5]; Down 200; 22.8uM; PC3; HT_HG-U133A

ABCG2 GPR176 SEC23A CNR2

1.69e-041933344623_DN
DrugCyanocobalamin [68-19-9]; Up 200; 3uM; PC3; HT_HG-U133A

NIPAL2 ADRA1D ABCG2 CNR2

1.83e-041973344572_UP
DrugMyosmine [532-12-7]; Down 200; 27.4uM; MCF7; HT_HG-U133A

IRF6 ADRA1D GOSR2 CNR2

1.83e-041973346055_DN
Drug(R) -Naproxen sodium salt [26159-34-2]; Up 200; 15.8uM; MCF7; HT_HG-U133A

ADRA1D CACNG5 CLSTN2 GPR176

1.83e-041973346096_UP
DrugClopamide [636-54-4]; Down 200; 11.6uM; MCF7; HT_HG-U133A

NIPAL2 IRF6 GOSR2 CNR2

1.83e-041973343220_DN
DrugTocainide hydrochloride; Down 200; 17.4uM; MCF7; HT_HG-U133A

NIPAL2 ADRA1D GOSR2 CNR2

1.86e-041983344838_DN
DrugQuinidine hydrochloride monohydrate [6151-40-2]; Up 200; 10.6uM; MCF7; HT_HG-U133A

NIPAL2 IRF6 CLSTN2 CNR2

1.86e-041983346267_UP
DrugDihydrostreptomycin sulfate [5490-27-7]; Up 200; 2.8uM; MCF7; HT_HG-U133A

IRF6 ADRA1D GOSR2 GPR176

1.90e-041993346228_UP
DrugTetrahydroalstonine [6474-90-4]; Up 200; 11.4uM; PC3; HT_HG-U133A

NIPAL2 ABCG2 RPRM GOSR2

1.90e-041993345728_UP
DrugDiphenylpyraline hydrochloride [132-18-3]; Down 200; 12.6uM; MCF7; HT_HG-U133A

NIPAL2 ADRA1D CLSTN2 CNR2

1.90e-041993344765_DN
Drug2aq7

ERBB3 ERBB4

2.11e-0415332CID005494446
Drugpropanedinitrile

ERBB3 ERBB4

2.41e-0416332CID000008010
Diseasegallbladder neoplasm

ERBB3 ERBB4

7.04e-0511342C0016978
DiseaseMalignant neoplasm of gallbladder

ERBB3 ERBB4

7.04e-0511342C0153452
Diseasemedian neuropathy (biomarker_via_orthology)

ERBB3 ERBB4

1.16e-0414342DOID:571 (biomarker_via_orthology)
Diseaselaryngeal squamous cell carcinoma (is_marker_for)

ERBB3 ERBB4

2.18e-0419342DOID:2876 (is_marker_for)
Diseasestomach carcinoma (is_marker_for)

ERBB3 ERBB4

3.50e-0424342DOID:5517 (is_marker_for)
DiseaseBreast Carcinoma

ERBB3 ERBB4 ABCG2 CNR2 PAEP

3.56e-04538345C0678222
Diseaseintestinal cancer (implicated_via_orthology)

ERBB3 ERBB4

6.25e-0432342DOID:10155 (implicated_via_orthology)
Diseasetongue squamous cell carcinoma (is_marker_for)

ERBB3 ERBB4

8.37e-0437342DOID:0050865 (is_marker_for)
Diseaseductal carcinoma in situ (is_marker_for)

ERBB3 ERBB4

9.30e-0439342DOID:0060074 (is_marker_for)
Diseasealcohol use disorder (implicated_via_orthology)

ERBB3 ERBB4 ADRA1D

1.46e-03195343DOID:1574 (implicated_via_orthology)
Diseaselung adenocarcinoma (is_implicated_in)

ERBB3 ERBB4

1.46e-0349342DOID:3910 (is_implicated_in)
DiseaseOrofacial cleft

IRF6 GOSR2

1.59e-0351342HP_0000202
DiseaseSkin Neoplasms

ERBB3 ERBB4

2.12e-0359342C0037286
DiseaseMalignant neoplasm of skin

ERBB3 ERBB4

2.12e-0359342C0007114
DiseaseBipolar Disorder

ERBB3 ERBB4 CACNG5 CNR2

2.13e-03477344C0005586
Diseasepolycystic ovary syndrome

ERBB3 ERBB4

2.19e-0360342EFO_0000660
Diseasetransitional cell carcinoma (is_marker_for)

ERBB3 ERBB4

2.41e-0363342DOID:2671 (is_marker_for)
Diseaseurolithiasis

NIPAL2 ABCG2

2.41e-0363342MONDO_0024647
Diseasecarcinoma (implicated_via_orthology)

ERBB3 ERBB4

2.48e-0364342DOID:305 (implicated_via_orthology)
DiseaseAlcohol abuse

TAS2R16 CNR2

2.72e-0367342C0085762
DiseaseMammary Neoplasms, Human

ERBB3 ABCG2 CNR2 PAEP

3.01e-03525344C1257931

Protein segments in the cluster

PeptideGeneStartEntry
VIMIILMIPIAICIY

BTN2A3P

251

Q96KV6
AQPQICTIDVYMVMV

ERBB3

931

P21860
QPPICTIDVYMVMVK

ERBB4

941

Q15303
MRMLPSIIFTCIVYF

ABCG2

481

Q9UNQ0
TYSMVPIRVMVDLCN

GLDN

116

Q6ZMI3
VCMLVFVVAMGVYRV

CLSTN2

841

Q9H4D0
VMIIRCAKVIMDPYS

CTXND1

31

A0A1B0GTU2
MLCLINSMVNPVIYA

CNR2

286

P34972
RYVAICNPLLYMVTM

OR8B4

121

Q96RC9
VVMCLVSIILYRAIM

ANO7

511

Q6IWH7
LYMVVMTPGICIQLV

OR8U8

131

P0C7N1
PIQSMMCQYLARVLV

PAEP

131

P09466
AVVSLCYSPLMVMYV

OR11H2

261

Q8NH07
MVMVFILCSVPYATL

GPR176

271

Q14439
GMLLTCVVMFLVVQY

GOSR2

196

O14653
ICYVTVIIPKMLVNF

OR1L1

121

Q8NH94
RCFTIEYVMPMNTQL

CACNG5

71

Q9UF02
LQPEMCMVRKVIQFY

DNAH6

1726

Q9C0G6
LVQVIPVVARMIYEM

IRF6

391

O14896
LYMVVMTPGICIQLV

OR8U1

131

Q8NH10
MIPIQLTVFFMIIYV

TAS2R16

1

Q9NYV7
VVMVFVICWMPFYVV

SSTR1

276

P30872
PIFYIMFIIMIASCV

NIPAL2

246

Q9H841
QMPLIFLYVVDTCME

SEC23A

126

Q15436
PMAVIVVMYCRVYVV

ADRA1D

266

P25100
MVFPVMYNLIILVCR

CNGA4

41

Q8IV77
MVLFNFIIPVSMYVT

ATP11C

351

Q8NB49
GISFVIMCIFYMPTV

TXNDC16

11

Q9P2K2
RYVAICKPLQYMIVM

OR4E1

126

P0C645
LYIMRVVQIAVMCVL

RPRM

51

Q9NS64
KPVLALCVISYFVMM

SPCS2

111

Q15005
LCVISYFVMMGILTI

SPCS2

116

Q15005
KLIYFSVMSVCLMPV

SPPL2A

391

Q8TCT8
IVCMLVNIIFPMYVT

VN1R4

136

Q7Z5H5
YGFMMLVLVILCIVT

TM9SF3

481

Q9HD45
LCVEITMYSQMPVPV

TRAPPC10

606

P48553
FNMFVVIAVCIYVIP

SLC8A2

171

Q9UPR5