Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	poly(A) binding	PABPC1 PABPC4L PABPC3	4.78e-06	29	23	3	GO:0008143
GeneOntologyMolecularFunction	ligand-gated calcium channel activity	TRPM4 RYR2 ITPR2	5.88e-06	31	23	3	GO:0099604
GeneOntologyMolecularFunction	poly(U) RNA binding	PABPC1 PABPC4L PABPC3	7.80e-06	34	23	3	GO:0008266
GeneOntologyMolecularFunction	poly-purine tract binding	PABPC1 PABPC4L PABPC3	1.01e-05	37	23	3	GO:0070717
GeneOntologyMolecularFunction	poly-pyrimidine tract binding	PABPC1 PABPC4L PABPC3	1.19e-05	39	23	3	GO:0008187
GeneOntologyMolecularFunction	calcium ion binding	TRPM4 PLS3 RYR2 CIB2 CAPNS1 ITPR2	1.59e-04	749	23	6	GO:0005509
GeneOntologyMolecularFunction	intracellularly gated calcium channel activity	RYR2 ITPR2	1.92e-04	18	23	2	GO:0015278
GeneOntologyMolecularFunction	single-stranded RNA binding	PABPC1 PABPC4L PABPC3	2.73e-04	111	23	3	GO:0003727
GeneOntologyMolecularFunction	calcium channel activity	TRPM4 RYR2 ITPR2	4.24e-04	129	23	3	GO:0005262
GeneOntologyMolecularFunction	ligand-gated monoatomic cation channel activity	TRPM4 RYR2 ITPR2	5.39e-04	140	23	3	GO:0099094
GeneOntologyMolecularFunction	intracellularly ligand-gated monoatomic ion channel activity	RYR2 ITPR2	6.56e-04	33	23	2	GO:0005217
GeneOntologyMolecularFunction	calcium ion transmembrane transporter activity	TRPM4 RYR2 ITPR2	6.72e-04	151	23	3	GO:0015085
GeneOntologyMolecularFunction	ligand-gated monoatomic ion channel activity	TRPM4 RYR2 ITPR2	1.37e-03	193	23	3	GO:0015276
GeneOntologyMolecularFunction	ligand-gated channel activity	TRPM4 RYR2 ITPR2	1.45e-03	197	23	3	GO:0022834
GeneOntologyMolecularFunction	protein kinase A binding	RYR2 LRBA	2.02e-03	58	23	2	GO:0051018
GeneOntologyMolecularFunction	mRNA 3'-UTR binding	PABPC1 PABPC4L PABPC3	3.77e-03	276	23	3	GO:0003730
GeneOntologyMolecularFunction	cysteine-type endopeptidase activity	USP34 CAPNS1	4.37e-03	86	23	2	GO:0004197
GeneOntologyMolecularFunction	scaffold protein binding	RYR2 ITPR2	5.09e-03	93	23	2	GO:0097110
GeneOntologyMolecularFunction	gated channel activity	TRPM4 RYR2 ITPR2	6.41e-03	334	23	3	GO:0022836
GeneOntologyMolecularFunction	monoatomic cation channel activity	TRPM4 RYR2 ITPR2	6.90e-03	343	23	3	GO:0005261
GeneOntologyBiologicalProcess	response to purine-containing compound	TRPM4 RYR2 CIB2 PENK ITPR2	9.51e-07	166	23	5	GO:0014074
GeneOntologyBiologicalProcess	regulation of atrial cardiac muscle cell action potential	TRPM4 RYR2	7.13e-06	4	23	2	GO:0098910
GeneOntologyBiologicalProcess	response to organophosphorus	TRPM4 CIB2 PENK ITPR2	1.72e-05	142	23	4	GO:0046683
GeneOntologyBiologicalProcess	Purkinje myocyte to ventricular cardiac muscle cell communication	TRPM4 RYR2	1.78e-05	6	23	2	GO:0086068
GeneOntologyBiologicalProcess	Purkinje myocyte to ventricular cardiac muscle cell signaling	TRPM4 RYR2	1.78e-05	6	23	2	GO:0086029
GeneOntologyBiologicalProcess	cellular response to organic cyclic compound	TRPM4 FKBP4 RYR2 CIB2 PENK ITPR2	4.09e-05	605	23	6	GO:0071407
GeneOntologyBiologicalProcess	regulation of ventricular cardiac muscle cell action potential	TRPM4 RYR2	7.80e-05	12	23	2	GO:0098911
GeneOntologyBiologicalProcess	AV node cell to bundle of His cell signaling	TRPM4 RYR2	7.80e-05	12	23	2	GO:0086027
GeneOntologyBiologicalProcess	AV node cell action potential	TRPM4 RYR2	7.80e-05	12	23	2	GO:0086016
GeneOntologyBiologicalProcess	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	PABPC1 PABPC3	1.07e-04	14	23	2	GO:0060213
GeneOntologyBiologicalProcess	regulation of mRNA 3'-end processing	PABPC1 PABPC3	1.07e-04	14	23	2	GO:0031440
GeneOntologyBiologicalProcess	AV node cell to bundle of His cell communication	TRPM4 RYR2	1.24e-04	15	23	2	GO:0086067
GeneOntologyBiologicalProcess	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	PABPC1 PABPC3	1.41e-04	16	23	2	GO:1900153
GeneOntologyBiologicalProcess	regulation of nuclear-transcribed mRNA poly(A) tail shortening	PABPC1 PABPC3	1.41e-04	16	23	2	GO:0060211
GeneOntologyBiologicalProcess	response to epinephrine	RYR2 PENK	1.60e-04	17	23	2	GO:0071871
GeneOntologyBiologicalProcess	atrial cardiac muscle cell to AV node cell communication	TRPM4 RYR2	2.01e-04	19	23	2	GO:0086066
GeneOntologyBiologicalProcess	atrial cardiac muscle cell to AV node cell signaling	TRPM4 RYR2	2.01e-04	19	23	2	GO:0086026
GeneOntologyBiologicalProcess	atrial cardiac muscle cell action potential	TRPM4 RYR2	2.01e-04	19	23	2	GO:0086014
GeneOntologyBiologicalProcess	cellular response to ATP	TRPM4 CIB2	2.47e-04	21	23	2	GO:0071318
GeneOntologyBiologicalProcess	regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	PABPC1 PABPC3	4.10e-04	27	23	2	GO:1900151
GeneOntologyBiologicalProcess	regulation of cardiac conduction	TRPM4 RYR2	4.74e-04	29	23	2	GO:1903779
GeneOntologyBiologicalProcess	regulation of cardiac muscle cell action potential	TRPM4 RYR2	5.08e-04	30	23	2	GO:0098901
GeneOntologyBiologicalProcess	nuclear-transcribed mRNA poly(A) tail shortening	PABPC1 PABPC3	6.15e-04	33	23	2	GO:0000289
GeneOntologyBiologicalProcess	cell-cell signaling involved in cardiac conduction	TRPM4 RYR2	6.53e-04	34	23	2	GO:0086019
GeneOntologyBiologicalProcess	positive regulation of heart rate	TRPM4 RYR2	6.92e-04	35	23	2	GO:0010460
GeneOntologyBiologicalProcess	ventricular cardiac muscle cell action potential	TRPM4 RYR2	7.74e-04	37	23	2	GO:0086005
GeneOntologyBiologicalProcess	response to organic cyclic compound	TRPM4 FKBP4 RYR2 CIB2 PENK ITPR2	8.12e-04	1048	23	6	GO:0014070
GeneOntologyBiologicalProcess	response to ATP	TRPM4 CIB2	9.04e-04	40	23	2	GO:0033198
GeneOntologyBiologicalProcess	regulation of cardiac muscle cell contraction	TRPM4 RYR2	1.04e-03	43	23	2	GO:0086004
GeneOntologyBiologicalProcess	mRNA 3'-end processing	PABPC1 PABPC3	1.19e-03	46	23	2	GO:0031124
GeneOntologyBiologicalProcess	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	PABPC1 PABPC3	1.19e-03	46	23	2	GO:0000184
GeneOntologyBiologicalProcess	cellular response to nitrogen compound	TRPM4 RYR2 CIB2 PENK ITPR2	1.24e-03	752	23	5	GO:1901699
GeneOntologyBiologicalProcess	positive regulation of heart contraction	TRPM4 RYR2	1.35e-03	49	23	2	GO:0045823
GeneOntologyBiologicalProcess	positive regulation of blood circulation	TRPM4 RYR2	1.58e-03	53	23	2	GO:1903524
GeneOntologyBiologicalProcess	cellular response to cAMP	PENK ITPR2	1.58e-03	53	23	2	GO:0071320
GeneOntologyBiologicalProcess	regulation of actin filament-based movement	TRPM4 RYR2	1.58e-03	53	23	2	GO:1903115
GeneOntologyBiologicalProcess	positive regulation of cytosolic calcium ion concentration	TRPM4 RYR2 CIB2	1.91e-03	224	23	3	GO:0007204
GeneOntologyBiologicalProcess	cell communication involved in cardiac conduction	TRPM4 RYR2	1.96e-03	59	23	2	GO:0086065
GeneOntologyBiologicalProcess	cardiac muscle cell action potential involved in contraction	TRPM4 RYR2	2.16e-03	62	23	2	GO:0086002
GeneOntologyBiologicalProcess	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	PABPC1 PABPC3	2.37e-03	65	23	2	GO:0000288
GeneOntologyBiologicalProcess	calcium-mediated signaling	TRPM4 RYR2 ITPR2	3.10e-03	266	23	3	GO:0019722
GeneOntologyBiologicalProcess	positive regulation of fat cell differentiation	TRPM4 RREB1	3.48e-03	79	23	2	GO:0045600
GeneOntologyCellularComponent	mCRD-mediated mRNA stability complex	PABPC1 PABPC3	1.58e-05	6	22	2	GO:0106002
GeneOntologyCellularComponent	cytoplasmic stress granule	PABPC1 PABPC4L PABPC3	1.36e-04	96	22	3	GO:0010494
GeneOntologyCellularComponent	sarcoplasmic reticulum membrane	RYR2 ITPR2	1.02e-03	45	22	2	GO:0033017
GeneOntologyCellularComponent	cell-substrate junction	GDI2 PABPC1 MISP CIB2	1.08e-03	443	22	4	GO:0030055
GeneOntologyCellularComponent	stereocilium	PLS3 CIB2	2.38e-03	69	22	2	GO:0032420
GeneOntologyCellularComponent	cytoplasmic ribonucleoprotein granule	PABPC1 PABPC4L PABPC3	2.71e-03	269	22	3	GO:0036464
GeneOntologyCellularComponent	anchoring junction	ARVCF GDI2 PABPC1 MISP CIB2	2.98e-03	976	22	5	GO:0070161
GeneOntologyCellularComponent	stereocilium bundle	PLS3 CIB2	3.10e-03	79	22	2	GO:0032421
GeneOntologyCellularComponent	ribonucleoprotein granule	PABPC1 PABPC4L PABPC3	3.25e-03	287	22	3	GO:0035770
Domain	PABC	PABPC1 PABPC3	1.32e-05	5	22	2	PS51309
Domain	PolyA	PABPC1 PABPC3	1.32e-05	5	22	2	SM00517
Domain	PABP_1234	PABPC1 PABPC3	1.32e-05	5	22	2	IPR006515
Domain	PABP_HYD	PABPC1 PABPC3	1.32e-05	5	22	2	IPR002004
Domain	-	PABPC1 PABPC3	1.32e-05	5	22	2	1.10.1900.10
Domain	PABP	PABPC1 PABPC3	1.32e-05	5	22	2	PF00658
Domain	RIH_assoc	RYR2 ITPR2	1.98e-05	6	22	2	PF08454
Domain	RIH_assoc-dom	RYR2 ITPR2	1.98e-05	6	22	2	IPR013662
Domain	RYDR_ITPR	RYR2 ITPR2	1.98e-05	6	22	2	PF01365
Domain	RIH_dom	RYR2 ITPR2	1.98e-05	6	22	2	IPR000699
Domain	Ins145_P3_rcpt	RYR2 ITPR2	1.98e-05	6	22	2	IPR014821
Domain	Ryanodine_recept-rel	RYR2 ITPR2	1.98e-05	6	22	2	IPR015925
Domain	Ins145_P3_rec	RYR2 ITPR2	1.98e-05	6	22	2	PF08709
Domain	-	RYR2 ITPR2	1.98e-05	6	22	2	1.25.10.30
Domain	EF-hand_1	PLS3 RYR2 CIB2 CAPNS1	2.75e-05	152	22	4	PF00036
Domain	EFh	PLS3 RYR2 CIB2 CAPNS1	3.20e-05	158	22	4	SM00054
Domain	MIR	RYR2 ITPR2	5.93e-05	10	22	2	PS50919
Domain	MIR	RYR2 ITPR2	5.93e-05	10	22	2	PF02815
Domain	MIR	RYR2 ITPR2	5.93e-05	10	22	2	SM00472
Domain	MIR_motif	RYR2 ITPR2	5.93e-05	10	22	2	IPR016093
Domain	EF_HAND_2	PLS3 RYR2 CIB2 CAPNS1	1.40e-04	231	22	4	PS50222
Domain	EF_hand_dom	PLS3 RYR2 CIB2 CAPNS1	1.42e-04	232	22	4	IPR002048
Domain	-	PLS3 RYR2 CIB2 CAPNS1	2.24e-04	261	22	4	1.10.238.10
Domain	Ion_trans_dom	TRPM4 RYR2 ITPR2	3.13e-04	114	22	3	IPR005821
Domain	Ion_trans	TRPM4 RYR2 ITPR2	3.13e-04	114	22	3	PF00520
Domain	EF-hand-dom_pair	PLS3 RYR2 CIB2 CAPNS1	3.21e-04	287	22	4	IPR011992
Domain	RRM_dom_euk	PABPC1 PABPC3	3.30e-04	23	22	2	IPR003954
Domain	RRM_1	PABPC1 PABPC3	3.30e-04	23	22	2	SM00361
Domain	ARM-type_fold	ARVCF USP34 LRBA ITPR2	6.02e-04	339	22	4	IPR016024
Domain	EF-hand_8	RYR2 CAPNS1	7.26e-04	34	22	2	PF13833
Domain	EF_Hand_1_Ca_BS	PLS3 CIB2 CAPNS1	1.09e-03	175	22	3	IPR018247
Domain	EF_HAND_1	PLS3 CIB2 CAPNS1	1.70e-03	204	22	3	PS00018
Domain	-	ARVCF RIPOR3 LRBA	2.16e-03	222	22	3	1.25.10.10
Domain	ARM-like	ARVCF RIPOR3 LRBA	3.75e-03	270	22	3	IPR011989
Domain	EF-hand_7	PLS3 CIB2	4.46e-03	85	22	2	PF13499
Pathway	KEGG_MEDICUS_VARIANT_SCRAPIE_CONFORMATION_PRPSC_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY	RYR2 ITPR2	2.04e-04	19	16	2	M47760
Pathway	BIOCARTA_EIF4_PATHWAY	PABPC1 PABPC3	3.01e-04	23	16	2	MM1470
Pathway	REACTOME_DEADENYLATION_OF_MRNA	PABPC1 PABPC3	3.29e-04	24	16	2	MM15090
Pubmed	Functional local crosstalk of inositol 1,4,5-trisphosphate receptor- and ryanodine receptor-dependent Ca2+ release in atrial cardiomyocytes.	RYR2 ITPR2	4.18e-07	2	23	2	28158491
Pubmed	Characterization of two cytoplasmic poly(A)-binding proteins, PABPC1 and PABPC2, in mouse spermatogenic cells.	PABPC1 PABPC3	4.18e-07	2	23	2	19020299
Pubmed	Functional compensation for the loss of testis-specific poly(A)-binding protein, PABPC2, during mouse spermatogenesis.	PABPC1 PABPC3	4.18e-07	2	23	2	26971890
Pubmed	The promoter of the Poly(A) binding protein 2 (Pabp2) retroposon is derived from the 5'-untranslated region of the Pabp1 progenitor gene.	PABPC1 PABPC3	4.18e-07	2	23	2	10534404
Pubmed	Nucleotide sequence of a mouse testis poly(A) binding protein cDNA.	PABPC1 PABPC3	4.18e-07	2	23	2	1630930
Pubmed	The mouse gene encoding the testis-specific isoform of Poly(A) binding protein (Pabp2) is an expressed retroposon: intimations that gene expression in spermatogenic cells facilitates the creation of new genes.	PABPC1 PABPC3	4.18e-07	2	23	2	9732454
Pubmed	Mitochondrial calcium overload is a key determinant in heart failure.	RYR2 ITPR2	4.18e-07	2	23	2	26217001
Pubmed	Developmental expression of poly(A) binding protein mRNAs during spermatogenesis in the mouse.	PABPC1 PABPC3	4.18e-07	2	23	2	7893484
Pubmed	Levels of free PABP are limited by newly polyadenylated mRNA in early Spisula embryogenesis.	PABPC1 PABPC3	4.18e-07	2	23	2	10954604
Pubmed	Epab is dispensable for mouse spermatogenesis and male fertility.	PABPC1 PABPC3	1.25e-06	3	23	2	24599567
Pubmed	Embryonic Poly(A)-Binding Protein Is Required During Early Stages of Mouse Oocyte Development for Chromatin Organization, Transcriptional Silencing, and Meiotic Competence.	PABPC1 PABPC3	1.25e-06	3	23	2	26134869
Pubmed	Nuclear relocalisation of cytoplasmic poly(A)-binding proteins PABP1 and PABP4 in response to UV irradiation reveals mRNA-dependent export of metazoan PABPs.	PABPC1 PABPC3	1.25e-06	3	23	2	21940797
Pubmed	Epab and Pabpc1 are differentially expressed in the postnatal mouse ovaries.	PABPC1 PABPC3	1.25e-06	3	23	2	25370180
Pubmed	Epab and Pabpc1 are differentially expressed during male germ cell development.	PABPC1 PABPC3	1.25e-06	3	23	2	22814100
Pubmed	Human testis expresses a specific poly(A)-binding protein.	PABPC1 PABPC3	1.25e-06	3	23	2	11328870
Pubmed	Differential 3' Processing of Specific Transcripts Expands Regulatory and Protein Diversity Across Neuronal Cell Types.	PABPC1 PABPC3	1.25e-06	3	23	2	29578408
Pubmed	Cytoplasmic poly(A)-binding protein 1 (PABPC1) interacts with the RNA-binding protein hnRNPLL and thereby regulates immunoglobulin secretion in plasma cells.	PABPC1 PABPC3	1.25e-06	3	23	2	28611064
Pubmed	SIRT1 Functions as a Negative Regulator of Eukaryotic Poly(A)RNA Transport.	PABPC1 PABPC3	1.25e-06	3	23	2	28756945
Pubmed	Translation repression via modulation of the cytoplasmic poly(A)-binding protein in the inflammatory response.	PABPC1 PABPC3	1.25e-06	3	23	2	28635594
Pubmed	The poly(A)-binding protein genes, EPAB, PABPC1, and PABPC3 are differentially expressed in infertile men with non-obstructive azoospermia.	PABPC1 PABPC3	1.25e-06	3	23	2	26843391
Pubmed	Superovulation alters embryonic poly(A)-binding protein (Epab) and poly(A)-binding protein, cytoplasmic 1 (Pabpc1) gene expression in mouse oocytes and early embryos.	PABPC1 PABPC3	1.25e-06	3	23	2	25034140
Pubmed	A twin UGUA motif directs the balance between gene isoforms through CFIm and the mTORC1 signaling pathway.	PABPC1 PABPC3	1.25e-06	3	23	2	37665675
Pubmed	Domain-functional analyses of PIWIL1 and PABPC1 indicate their synergistic roles in protein translation via 3'-UTRs of meiotic mRNAs.	PABPC1 PABPC3	1.25e-06	3	23	2	29701755
Pubmed	De novo variants in the PABP domain of PABPC1 lead to developmental delay.	PABPC1 PABPC3	1.25e-06	3	23	2	35511136
Pubmed	The mouse Y-box protein, MSY2, is associated with a kinase on non-polysomal mouse testicular mRNAs.	PABPC1 PABPC3	1.25e-06	3	23	2	10076007
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	ARVCF GDI2 PACSIN1 PABPC1 PLS3 MISP PABPC3 ITPR2	2.27e-06	1431	23	8	37142655
Pubmed	UNR, a new partner of poly(A)-binding protein, plays a key role in translationally coupled mRNA turnover mediated by the c-fos major coding-region determinant.	PABPC1 PABPC3	2.51e-06	4	23	2	15314026
Pubmed	Regulation of poly(A) binding protein function in translation: Characterization of the Paip2 homolog, Paip2B.	PABPC1 PABPC3	2.51e-06	4	23	2	16804161
Pubmed	Stress granules inhibit apoptosis by reducing reactive oxygen species production.	PABPC1 PABPC3	2.51e-06	4	23	2	23230274
Pubmed	Evolution of complexity in the zebrafish synapse proteome.	PABPC1 PABPC3	2.51e-06	4	23	2	28252024
Pubmed	RNA-binding proteins in mouse oocytes and embryos: expression of genes encoding Y box, DEAD box RNA helicase, and polyA binding proteins.	PABPC1 PABPC3	2.51e-06	4	23	2	9883581
Pubmed	An embryonic poly(A)-binding protein (ePAB) is expressed in mouse oocytes and early preimplantation embryos.	PABPC1 PABPC3	2.51e-06	4	23	2	15630085
Pubmed	Hypoxia differently modulates gene expression of inositol 1,4,5-trisphosphate receptors in mouse kidney and HEK 293 cell line.	RYR2 ITPR2	2.51e-06	4	23	2	19120137
Pubmed	Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.	PABPC1 PABPC3	2.51e-06	4	23	2	24129315
Pubmed	cTag-PAPERCLIP Reveals Alternative Polyadenylation Promotes Cell-Type Specific Protein Diversity and Shifts Araf Isoforms with Microglia Activation.	PABPC1 PABPC3	2.51e-06	4	23	2	28910620
Pubmed	Transthyretin Upregulates Long Non-Coding RNA MEG3 by Affecting PABPC1 in Diabetic Retinopathy.	PABPC1 PABPC3	2.51e-06	4	23	2	31847264
Pubmed	Neural RNA-binding protein Musashi1 inhibits translation initiation by competing with eIF4G for PABP.	PABPC1 PABPC3	2.51e-06	4	23	2	18490513
Pubmed	ATXN2-CAG42 sequesters PABPC1 into insolubility and induces FBXW8 in cerebellum of old ataxic knock-in mice.	PABPC1 PABPC3	2.51e-06	4	23	2	22956915
Pubmed	Functional cloning of genes that suppress oxidative stress-induced cell death: TCTP prevents hydrogen peroxide-induced cell death.	PABPC1 PABPC3	2.51e-06	4	23	2	19328788
Pubmed	Embryonic Poly(A)-Binding Protein (EPAB) Is Required for Granulosa Cell EGF Signaling and Cumulus Expansion in Female Mice.	PABPC1 PABPC3	4.18e-06	5	23	2	26492470
Pubmed	Isolation of cDNAs from a mouse astroglial cell line by a subtracted cDNA library.	PABPC1 PABPC3	4.18e-06	5	23	2	1701491
Pubmed	AKAP3 synthesis is mediated by RNA binding proteins and PKA signaling during mouse spermiogenesis.	PABPC1 PABPC3	4.18e-06	5	23	2	24648398
Pubmed	HIV- 1 protease inhibits Cap- and poly(A)-dependent translation upon eIF4GI and PABP cleavage.	PABPC1 PABPC3	4.18e-06	5	23	2	19956697
Pubmed	MKRN3-mediated ubiquitination of Poly(A)-binding proteins modulates the stability and translation of GNRH1 mRNA in mammalian puberty.	PABPC1 PABPC3	4.18e-06	5	23	2	33744966
Pubmed	Interaction of HuDA and PABP at 5'UTR of mouse insulin2 regulates insulin biosynthesis.	PABPC1 PABPC3	4.18e-06	5	23	2	29590218
Pubmed	Poly(A) tail length regulates PABPC1 expression to tune translation in the heart.	PABPC1 PABPC3	4.18e-06	5	23	2	28653618
Pubmed	IP3Rs are sufficient for dendritic cell Ca2+ signaling in the absence of RyR1.	RYR2 ITPR2	6.26e-06	6	23	2	16844763
Pubmed	Embryonic poly(A)-binding protein is differently expressed and interacts with the messenger RNAs in the mouse oocytes and early embryos.	PABPC1 PABPC3	6.26e-06	6	23	2	30302808
Pubmed	Roles of I(f) and intracellular Ca2+ release in spontaneous activity of ventricular cardiomyocytes during murine embryonic development.	RYR2 ITPR2	6.26e-06	6	23	2	23463619
Pubmed	A calcium-induced calcium release mechanism supports luteinizing hormone-induced testosterone secretion in mouse Leydig cells.	RYR2 ITPR2	6.26e-06	6	23	2	20519450
Pubmed	Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging.	RYR2 ITPR2	6.26e-06	6	23	2	25966694
Pubmed	Translation of insulin granule proteins are regulated by PDI and PABP.	PABPC1 PABPC3	6.26e-06	6	23	2	32248978
Pubmed	Disruption of mouse poly(A) polymerase mGLD-2 does not alter polyadenylation status in oocytes and somatic cells.	PABPC1 PABPC3	6.26e-06	6	23	2	17927953
Pubmed	The eukaryotic polypeptide chain releasing factor (eRF3/GSPT) carrying the translation termination signal to the 3'-Poly(A) tail of mRNA. Direct association of erf3/GSPT with polyadenylate-binding protein.	PABPC1 PABPC3	6.26e-06	6	23	2	10358005
Pubmed	NMD abnormalities during brain development in the Fmr1-knockout mouse model of fragile X syndrome.	PABPC1 PABPC3	8.77e-06	7	23	2	34784943
Pubmed	Developmental expression of the calcium release channels during early neurogenesis of the mouse cerebral cortex.	RYR2 ITPR2	8.77e-06	7	23	2	11860456
Pubmed	E3 ligase MKRN3 is a tumor suppressor regulating PABPC1 ubiquitination in non-small cell lung cancer.	PABPC1 PABPC3	8.77e-06	7	23	2	34143182
Pubmed	Genetic imbalances in preleukemic thymuses.	PABPC1 PABPC3	8.77e-06	7	23	2	11322760
Pubmed	Chromosomal localization of three human poly(A)-binding protein genes and four related pseudogenes.	PABPC1 PABPC3	8.77e-06	7	23	2	10543404
Pubmed	ADAM10 hyperactivation acts on piccolo to deplete synaptic vesicle stores in Huntington's disease.	GDI2 PABPC1 PLS3 PABPC3	8.97e-06	202	23	4	33601422
Pubmed	Embryonic poly(A)-binding protein (EPAB) is required for oocyte maturation and female fertility in mice.	PABPC1 PABPC3	1.17e-05	8	23	2	22621333
Pubmed	Roles of IP3R and RyR Ca2+ channels in endoplasmic reticulum stress and beta-cell death.	RYR2 ITPR2	1.17e-05	8	23	2	19033399
Pubmed	Over-expression of Grhl2 causes spina bifida in the Axial defects mutant mouse.	PABPC1 PABPC3	1.17e-05	8	23	2	21262862
Pubmed	Rho-associated protein kinase-dependent moesin phosphorylation is required for PD-L1 stabilization in breast cancer.	GDI2 PLS3 FKBP4 LRBA	1.35e-05	224	23	4	32941674
Pubmed	Control of Paip1-eukayrotic translation initiation factor 3 interaction by amino acids through S6 kinase.	PABPC1 PABPC3	1.50e-05	9	23	2	24396066
Pubmed	Deadenylation is prerequisite for P-body formation and mRNA decay in mammalian cells.	PABPC1 PABPC3	1.50e-05	9	23	2	18625844
Pubmed	RNA binding protein RBM46 regulates mitotic-to-meiotic transition in spermatogenesis.	PABPC1 PABPC3	1.50e-05	9	23	2	36001654
Pubmed	Embryonic poly(A)-binding protein is required at the preantral stage of mouse folliculogenesis for oocyte-somatic communication.	PABPC1 PABPC3	1.50e-05	9	23	2	28203794
Pubmed	Granzyme B proteolyzes receptors important to proliferation and survival, tipping the balance toward apoptosis.	PABPC1 PABPC3	1.88e-05	10	23	2	16798735
Pubmed	The RNA recognition motif protein RBM11 is a novel tissue-specific splicing regulator.	PABPC1 PABPC3	1.88e-05	10	23	2	21984414
Pubmed	Plasticity in the Glucagon Interactome Reveals Novel Proteins That Regulate Glucagon Secretion in α-TC1-6 Cells.	GDI2 PABPC1 FKBP4 PABPC3	1.98e-05	247	23	4	30713523
Pubmed	Regulation of PKD by the MAPK p38delta in insulin secretion and glucose homeostasis.	GDI2 PABPC1 PLS3	2.32e-05	84	23	3	19135240
Pubmed	The Deubiquitinating Enzyme USP48 Interacts with the Retinal Degeneration-Associated Proteins UNC119a and ARL3.	GDI2 PACSIN1 PABPC1 FKBP4 PABPC3	2.63e-05	552	23	5	36293380
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	USP34 GDI2 PABPC1 PLS3 FKBP4 CAPNS1 LRBA	3.00e-05	1455	23	7	22863883
Pubmed	The arginine methyltransferase CARM1 regulates the coupling of transcription and mRNA processing.	PABPC1 PABPC3	3.25e-05	13	23	2	17218272
Pubmed	Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation.	PABPC1 PABPC3	3.79e-05	14	23	2	19716330
Pubmed	Uncovering a mammalian neural-specific poly(A) binding protein with unique properties.	PABPC1 PABPC3	4.37e-05	15	23	2	37704377
Pubmed	Calcium handling precedes cardiac differentiation to initiate the first heartbeat.	RYR2 ITPR2	5.66e-05	17	23	2	27725084
Pubmed	JAKMIP1, a Novel Regulator of Neuronal Translation, Modulates Synaptic Function and Autistic-like Behaviors in Mouse.	PABPC1 PABPC3	5.66e-05	17	23	2	26627310
Pubmed	Interactome analysis of Bag-1 isoforms reveals novel interaction partners in endoplasmic reticulum-associated degradation.	GDI2 PABPC1 PLS3 FKBP4	5.90e-05	327	23	4	34428256
Pubmed	VCP interaction with HMGB1 promotes hepatocellular carcinoma progression by activating the PI3K/AKT/mTOR pathway.	PABPC1 PLS3 FKBP4 CAPNS1	6.04e-05	329	23	4	35562734
Pubmed	The functional interactome of PYHIN immune regulators reveals IFIX is a sensor of viral DNA.	PABPC1 PLS3 FKBP4 RREB1	7.59e-05	349	23	4	25665578
Pubmed	Proteomic analysis of integrin-associated complexes identifies RCC2 as a dual regulator of Rac1 and Arf6.	GDI2 PABPC1 FKBP4 CAPNS1 LRBA	8.50e-05	707	23	5	19738201
Pubmed	A genome-scale RNAi screen for Oct4 modulators defines a role of the Paf1 complex for embryonic stem cell identity.	PABPC1 PABPC3	8.72e-05	21	23	2	19345177
Pubmed	RUNX1 maintains the identity of the fetal ovary through an interplay with FOXL2.	RYR2 ITPR2	8.72e-05	21	23	2	31712577
Pubmed	Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma.	GDI2 PABPC4L PLS3 FKBP4 ITPR2	1.00e-04	732	23	5	34732716
Pubmed	LINC01554-Mediated Glucose Metabolism Reprogramming Suppresses Tumorigenicity in Hepatocellular Carcinoma via Downregulating PKM2 Expression and Inhibiting Akt/mTOR Signaling Pathway.	GDI2 PABPC1 ITPR2	1.11e-04	142	23	3	30809309
Pubmed	Temporally defined neocortical translation and polysome assembly are determined by the RNA-binding protein Hu antigen R.	PABPC1 PABPC3	1.14e-04	24	23	2	25157170
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	PABPC1 PLS3 MISP FKBP4 CAPNS1 ITPR2	1.31e-04	1257	23	6	36526897
Pubmed	WDFY4 is required for cross-presentation in response to viral and tumor antigens.	PABPC1 PLS3 PABPC3	1.47e-04	156	23	3	30409884
Pubmed	Cell cycle-dependent palmitoylation of protocadherin 7 by ZDHHC5 promotes successful cytokinesis.	GDI2 PABPC1 FKBP4	1.55e-04	159	23	3	36762613
Pubmed	TERRA transcripts are bound by a complex array of RNA-binding proteins.	PABPC1 PABPC3	1.56e-04	28	23	2	20975687
Pubmed	Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.	GDI2 PABPC1 FKBP4 CAPNS1 LRBA	1.58e-04	807	23	5	30575818
Pubmed	Interaction of tau with the RNA-Binding Protein TIA1 Regulates tau Pathophysiology and Toxicity.	PACSIN1 PABPC1 PABPC3	1.76e-04	166	23	3	27160897
Pubmed	NFX1-123 and poly(A) binding proteins synergistically augment activation of telomerase in human papillomavirus type 16 E6-expressing cells.	PABPC1 PABPC3	2.05e-04	32	23	2	17267499
Pubmed	Expression of genes involved in mammalian meiosis during the transition from egg to embryo.	PABPC1 PABPC3	2.18e-04	33	23	2	11389549
Pubmed	LKB1 deletion causes early changes in atrial channel expression and electrophysiology prior to atrial fibrillation.	RYR2 ITPR2	2.32e-04	34	23	2	26378152
Pubmed	CDK7/GRP78 signaling axis contributes to tumor growth and metastasis in osteosarcoma.	PLS3 MISP PABPC3 CAPNS1	2.34e-04	468	23	4	36042349
Pubmed	PINK1 Content in Mitochondria is Regulated by ER-Associated Degradation.	PABPC1 PLS3 MISP FKBP4	2.52e-04	477	23	4	31300519
Pubmed	AMPK, a Regulator of Metabolism and Autophagy, Is Activated by Lysosomal Damage via a Novel Galectin-Directed Ubiquitin Signal Transduction System.	GDI2 PABPC1 PLS3 FKBP4	2.66e-04	484	23	4	31995728
Interaction	CAST interactions	PABPC1 PLS3 CAPNS1 LRBA	6.62e-06	109	23	4	int:CAST
GeneFamily	EF-hand domain containing	PLS3 RYR2 CIB2 CAPNS1	7.04e-05	219	19	4	863
GeneFamily	RNA binding motif containing	PABPC1 PABPC4L PABPC3	1.36e-03	213	19	3	725
Coexpression	GSE369_SOCS3_KO_VS_IFNG_KO_LIVER_UP	ING5 PLS3 MISP ITPR2	2.55e-05	199	23	4	M5978
Coexpression	GSE37301_HEMATOPOIETIC_STEM_CELL_VS_MULTIPOTENT_PROGENITOR_UP	USP34 FKBP4 RYR2 LRBA	2.60e-05	200	23	4	M8836
Coexpression	GSE17721_PAM3CSK4_VS_CPG_12H_BMDC_UP	USP34 FKBP4 CIB2 LRBA	2.60e-05	200	23	4	M3867
Coexpression	GROSS_HYPOXIA_VIA_HIF1A_ONLY	PABPC1 PABPC3	3.30e-05	10	23	2	MM1122
Coexpression	LIU_OVARIAN_CANCER_TUMORS_AND_XENOGRAFTS_XDGS_UP	PACSIN1 PABPC1 PABPC3	1.13e-04	108	23	3	MM1334
Coexpression	PARK_HSC_VS_MULTIPOTENT_PROGENITORS_UP	PABPC1 CAPNS1	1.25e-04	19	23	2	M1412
Coexpression	TABULA_MURIS_SENIS_AORTA_AORTIC_ENDOTHELIAL_CELL_AGEING	PABPC1 PABPC4L PABPC3 CAPNS1	1.79e-04	329	23	4	MM3671
Coexpression	VALK_AML_WITH_11Q23_REARRANGED	TRPM4 PENK	1.84e-04	23	23	2	M9270
Coexpression	VALK_AML_CLUSTER_16	TRPM4 PENK	2.75e-04	28	23	2	M16673
Coexpression	HSIAO_HOUSEKEEPING_GENES	GDI2 PABPC1 FKBP4 CAPNS1	3.65e-04	397	23	4	M11197
Coexpression	GSE13547_2H_VS_12_H_ANTI_IGM_STIM_ZFX_KO_BCELL_UP	PACSIN1 PENK ITPR2	4.10e-04	167	23	3	M2995
Coexpression	PAL_PRMT5_TARGETS_DN	PABPC1 PABPC3	4.31e-04	35	23	2	MM674
Coexpression	GAUSSMANN_MLL_AF4_FUSION_TARGETS_C_UP	PABPC1 PABPC3 RREB1	4.85e-04	177	23	3	MM479
Coexpression	CUI_TCF21_TARGETS_2_UP	TRPM4 MISP FKBP4 PENK	5.25e-04	437	23	4	M1610
Coexpression	CUI_TCF21_TARGETS_2_UP	TRPM4 MISP FKBP4 PENK	6.11e-04	455	23	4	MM1189
Coexpression	GSE360_L_MAJOR_VS_M_TUBERCULOSIS_MAC_UP	PABPC1 MISP CIB2	6.53e-04	196	23	3	M5252
Coexpression	GSE17186_MEMORY_VS_CD21HIGH_TRANSITIONAL_BCELL_UP	TRPM4 LRBA ITPR2	6.73e-04	198	23	3	M7200
Coexpression	GSE3982_DC_VS_MAC_LPS_STIM_DN	PLS3 CAPNS1 LRBA	6.83e-04	199	23	3	M5390
Coexpression	GSE46242_CTRL_VS_EGR2_DELETED_TH1_CD4_TCELL_UP	GDI2 TRPM4 CAPNS1	6.83e-04	199	23	3	M9705
Coexpression	GSE17721_LPS_VS_CPG_12H_BMDC_UP	MISP PENK RREB1	6.83e-04	199	23	3	M4005
Coexpression	GSE360_L_DONOVANI_VS_T_GONDII_MAC_UP	ARVCF MISP PENK	6.83e-04	199	23	3	M5233
Coexpression	GSE15930_STIM_VS_STIM_AND_IL12_48H_CD8_T_CELL_DN	PLS3 FKBP4 LRBA	6.93e-04	200	23	3	M3631
Coexpression	GSE21927_SPLEEN_C57BL6_VS_4T1_TUMOR_BALBC_MONOCYTES_UP	USP34 PABPC1 PABPC3	6.93e-04	200	23	3	M7594
Coexpression	GSE44649_NAIVE_VS_ACTIVATED_CD8_TCELL_MIR155_KO_DN	PLS3 LRBA RREB1	6.93e-04	200	23	3	M9777
Coexpression	GSE12003_MIR223_KO_VS_WT_BM_PROGENITOR_4D_CULTURE_UP	USP34 MISP PENK	6.93e-04	200	23	3	M387
Coexpression	GSE46606_DAY1_VS_DAY3_CD40L_IL2_IL5_STIMULATED_IRF4_KO_BCELL_DN	USP34 TRPM4 RYR2	6.93e-04	200	23	3	M9827
Coexpression	GSE13229_MATURE_VS_INTMATURE_NKCELL_UP	ARVCF PACSIN1 PENK	6.93e-04	200	23	3	M3213
Coexpression	GSE40273_GATA1_KO_VS_WT_TREG_DN	ING5 GIMAP8 ITPR2	6.93e-04	200	23	3	M9133
Coexpression	GSE26912_TUMORICIDAL_VS_CTRL_MACROPHAGE_UP	WNT10A PLS3 PENK	6.93e-04	200	23	3	M8205
Coexpression	GSE360_L_DONOVANI_VS_M_TUBERCULOSIS_MAC_UP	GDI2 PABPC1 MISP	6.93e-04	200	23	3	M5241
Coexpression	GSE360_L_DONOVANI_VS_L_MAJOR_MAC_UP	GDI2 MISP LRBA	6.93e-04	200	23	3	M5231
Coexpression	GSE7831_UNSTIM_VS_CPG_STIM_PDC_4H_DN	PACSIN1 PLS3 RYR2	6.93e-04	200	23	3	M6954
ToppCell	Influenza_Severe-pDC\|World / Disease group and Cell class	PACSIN1 PLS3 PABPC3 CIB2	1.50e-06	166	23	4	bd25ce4c03c3d6cd9d986b9be1d355da52f0f2d7
ToppCell	Influenza_Severe-pDC\|Influenza_Severe / Disease group and Cell class	PACSIN1 PLS3 PABPC3 CIB2	1.50e-06	166	23	4	b43a5cd4d28118cf6e56a435deb8ea9435608a90
ToppCell	severe_influenza-pDC\|severe_influenza / disease group, cell group and cell class (v2)	PACSIN1 PLS3 PABPC3 CIB2	1.81e-06	174	23	4	d8d2ded5812ed3b3db4109585714a6513c13326a
ToppCell	healthy_donor-Lymphocytic-Dendritic\|healthy_donor / Disease condition, Lineage, Cell class and subclass	WNT10A PACSIN1 PLS3 CIB2	2.35e-06	186	23	4	916f2aeea4989ba7a29e071e348a51010f010223
ToppCell	control-Myeloid-pDC\|control / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	WNT10A PACSIN1 PLS3 CIB2	2.35e-06	186	23	4	fe31e9cf4575ee40b50489593c51d8c36c3cc532
ToppCell	control-Myeloid-pDC\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	WNT10A PACSIN1 PLS3 CIB2	2.35e-06	186	23	4	fccee4cfcc887358cf916d974f29627095b5ad9c
ToppCell	healthy_donor-Lymphocytic-Dendritic-pDC\|healthy_donor / Disease condition, Lineage, Cell class and subclass	WNT10A PACSIN1 PLS3 CIB2	2.35e-06	186	23	4	45f66619e45d590c7365a51782d4ac46b7d31fde
ToppCell	droplet-Skin-nan-21m-Epithelial-basal_cell_of_epidermis\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WNT10A CIB2 CAPNS1 ITPR2	2.56e-06	190	23	4	c1bfc1960a3df49c0f459454a7363804c32418ee
ToppCell	PBMC-Control-cDC_3\|Control / Compartment, Disease Groups and Clusters	GDI2 PABPC1 PABPC3 CAPNS1	2.90e-06	196	23	4	09d197b321ff9f13c0672ea059c850845b0dbbd5
ToppCell	mild-pDC\|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	WNT10A PACSIN1 PLS3 CIB2	2.96e-06	197	23	4	15230a54fa5903dd728de1a0ad633bd2d2c7a04d
ToppCell	Sepsis-Leuk-UTI-Myeloid-pDC\|Leuk-UTI / Disease, condition lineage and cell class	WNT10A PACSIN1 PLS3 CIB2	3.08e-06	199	23	4	2f8d297afd26ae1e9fb66d8573274452c4133b6c
ToppCell	10x_3'_v3-lymph_node_(10x_3'_v3)-myeloid-myeloid_dendritic-plasmacytoid_dendritic_cell\|lymph_node_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	PACSIN1 PLS3 CIB2	5.65e-05	146	23	3	bee5074c29b132180d35f57d307e342efa9b8cd1
ToppCell	severe_COVID-19-pDC\|World / disease group, cell group and cell class (v2)	WNT10A PACSIN1 CIB2	7.28e-05	159	23	3	e1c48c4ceda116826819ff9adeed7bad6a58844d
ToppCell	severe_COVID-19-pDC\|severe_COVID-19 / disease group, cell group and cell class (v2)	WNT10A PACSIN1 CIB2	7.28e-05	159	23	3	ea5088d27e42b8850455764d53b757ea8d8f14bc
ToppCell	LPS-IL1RA-Myeloid-Dendritic_cells-pDC\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	WNT10A PACSIN1 CIB2	7.42e-05	160	23	3	dee756a2dc9725520d439e7273c489c2284015d8
ToppCell	LAM-Lymphoid-pDC\|LAM / Condition, Lineage and Cell class	WNT10A PACSIN1 CIB2	7.56e-05	161	23	3	bb5b44713e4da4406cdaa79dcf2aa9f97e3cf75a
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell-Plasmacytoid_DCs-Plasmacytoid_DCs_L.1.5.1.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	WNT10A PACSIN1 CIB2	8.13e-05	165	23	3	e2a70dd5870fe8708bf630ed3e6eb3f295df0cdf
ToppCell	NS-critical-d_07-13-Myeloid-pDC\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	WNT10A PACSIN1 CIB2	8.13e-05	165	23	3	17d5c4a111d9b5400780bc5e7b93ce2f5d69ceb7
ToppCell	3'-Parenchyma_lung-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ARVCF MISP ITPR2	8.42e-05	167	23	3	49d9220f22d10ff06c0512c9c40c26ad51728e4f
ToppCell	3'-Parenchyma_lung-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte-Ionocyte_L.0.7.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ARVCF MISP ITPR2	8.42e-05	167	23	3	7ec032a98a13504d15c7e3a4e259278d07f40180
ToppCell	mild_COVID-19_(asymptomatic)-pDC\|World / disease group, cell group and cell class (v2)	TRPM4 PLS3 CIB2	8.42e-05	167	23	3	bf08f17965a4dd03f371b4ed0ab0d5e62ed61307
ToppCell	3'-Parenchyma_lung-Epithelial-Neuro-endocrine/ionocytic-ionocyte\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ARVCF MISP ITPR2	8.42e-05	167	23	3	5e3588eee73693a996bb4846427cf0038ceafbca
ToppCell	mild_COVID-19_(asymptomatic)-pDC\|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)	PACSIN1 PLS3 CIB2	8.57e-05	168	23	3	968405ea56f7d001ef83ff9274610923c3b2d55d
ToppCell	(3)_MNP-(3)_DC_plasmacytoid\|(3)_MNP / Lung cell shreds - cell class (v4) and cell subclass (v4)	WNT10A PACSIN1 CIB2	8.57e-05	168	23	3	13c160ea1a19b47d2e7e2dae818c8dcde4e3e377
ToppCell	Healthy_Control-Lymphoid-pDC\|Healthy_Control / Condition, Lineage, Cell class and cell subclass	WNT10A PACSIN1 CIB2	8.72e-05	169	23	3	a4e9b8b2f0338203455ba941b8f99bf4884d26f0
ToppCell	Healthy_Control-Lymphoid-pDC-\|Healthy_Control / Condition, Lineage, Cell class and cell subclass	WNT10A PACSIN1 CIB2	8.72e-05	169	23	3	338ce99897cb522b86edd603f75bc15ec4dfcda3
ToppCell	severe_influenza-pDC\|World / disease group, cell group and cell class (v2)	PACSIN1 PABPC3 CIB2	8.88e-05	170	23	3	b9c08af83241666bbdbed9109cadcd088c0f647d
ToppCell	COVID_vent-Lymphocytic-Dendritic-pDC\|COVID_vent / Disease condition, Lineage, Cell class and subclass	PACSIN1 PLS3 CIB2	9.03e-05	171	23	3	779c951d274ecbd1d546ac425d6c8e718623be5a
ToppCell	COVID_vent-Lymphocytic-Dendritic\|COVID_vent / Disease condition, Lineage, Cell class and subclass	PACSIN1 PLS3 CIB2	9.03e-05	171	23	3	debbb071d260639b16269c94d172766908325c58
ToppCell	normal_Lymph_Node-Myeloid_cells-pDCs\|Myeloid_cells / Location, Cell class and cell subclass	PACSIN1 CIB2 LRBA	9.51e-05	174	23	3	2274648b80dd74f3c948a779bba3391095964c34
ToppCell	BAL-Control-Myeloid-pDC-pDC-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	WNT10A PACSIN1 CIB2	9.51e-05	174	23	3	ab654e87c7eab7f33adc61be7a86da5c4d88008d
ToppCell	BAL-Control-Myeloid-pDC-pDC\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	WNT10A PACSIN1 CIB2	9.51e-05	174	23	3	2453419842fd22d066631615403393bfe4449bb8
ToppCell	3'-Broncho-tracheal-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell-EC_arterial-EC_arterial_L.2.4.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PABPC4L GIMAP8 ITPR2	9.51e-05	174	23	3	18ab52d8bbca0507fee220e0c4fc765fc47dda34
ToppCell	BAL-Control-Myeloid-pDC\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	WNT10A PACSIN1 CIB2	9.51e-05	174	23	3	d9bccff5258c4277bdd1edbd87e17c327ec125e8
ToppCell	droplet-Kidney-KIDNEY-30m-Mesenchymal-podocyte\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRPM4 MISP CIB2	9.67e-05	175	23	3	31f0fb2e47e357dbf9c15436b7df85b3c370ded7
ToppCell	BAL-Control-Myeloid-pDC\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	WNT10A PACSIN1 CIB2	9.67e-05	175	23	3	6d5bdfbe53608e01c3845ecd908ca6d0fecc58f8
ToppCell	10x_3'_v3-tissue-resident_(10x_3'_v3)-myeloid-myeloid_dendritic-plasmacytoid_dendritic_cell\|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	WNT10A PACSIN1 CIB2	9.67e-05	175	23	3	97fe431f224b592b3076632d101e19136c138dcc
ToppCell	BAL-Control-Myeloid-pDC-pDC-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	WNT10A PACSIN1 CIB2	9.67e-05	175	23	3	6839ee3bb4457d13cb08ca8eb79ae33ddd256783
ToppCell	BAL-Control-Myeloid-pDC-pDC\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	WNT10A PACSIN1 CIB2	9.67e-05	175	23	3	9d6135e183179968555670abec39dff9da2c3219
ToppCell	mild-Myeloid-pDC\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	WNT10A PACSIN1 CIB2	9.84e-05	176	23	3	59a9c262c252b7d220a025837922d98e9d6b0a24
ToppCell	Control-Myeloid-pDC\|Control / Disease group,lineage and cell class （2021.01.30）	WNT10A PACSIN1 CIB2	9.84e-05	176	23	3	baa3563973ea1a351fe028f55828463d2a51bf1a
ToppCell	droplet-Kidney-KIDNEY-30m-Epithelial-Epcam____podocyte-2\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PABPC4L MISP CIB2	1.00e-04	177	23	3	8f0873d348f37c823294b698043319b6608b678a
ToppCell	myeloid-Dendritic_cell-Plasmacytoid_dendritic_cell\|myeloid / Lineage, cell class and subclass	WNT10A PACSIN1 CIB2	1.02e-04	178	23	3	f75591988bbbeba073b66329a3437cb9b02f7648
ToppCell	normal_Lung-B_lymphocytes\|normal_Lung / Location, Cell class and cell subclass	WNT10A PACSIN1 CIB2	1.03e-04	179	23	3	5b89193486100b6754c1c5eca3105ea955805eae
ToppCell	moderate-Myeloid-pDC\|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	WNT10A PACSIN1 CIB2	1.05e-04	180	23	3	a0751ad5e42a21cb107d900abfa9ee967a0069fc
ToppCell	moderate-Myeloid-pDC\|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	WNT10A PACSIN1 CIB2	1.05e-04	180	23	3	1d8df7df03a71f49d6683554d3c948ce90dda42e
ToppCell	NS-moderate-d_16-33-Myeloid-pDC\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	WNT10A PACSIN1 CIB2	1.05e-04	180	23	3	144818e69613296cde43f29cb8c20899c670b319
ToppCell	metastatic_Lymph_Node-Myeloid_cells-pDCs\|Myeloid_cells / Location, Cell class and cell subclass	WNT10A PACSIN1 CIB2	1.09e-04	182	23	3	02e04294fce12591c32d7bd0e866a000ad1f836e
ToppCell	normal_Lung-B_lymphocytes-GrB-secreting_B_cells\|normal_Lung / Location, Cell class and cell subclass	WNT10A PACSIN1 CIB2	1.10e-04	183	23	3	c930b957d16f9b0904b6c424acd914532e5cc137
ToppCell	droplet-Kidney-KIDNEY-1m-Epithelial-Epcam____podocyte-2\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PABPC4L MISP CIB2	1.12e-04	184	23	3	e123ad8ee46a032825a0bd4b3586ddcb3eda03d4
ToppCell	ICU-NoSEP-Myeloid-pDC\|ICU-NoSEP / Disease, Lineage and Cell Type	WNT10A PACSIN1 CIB2	1.14e-04	185	23	3	7564a47df4a4e3af30d40aa0f48bd9d9c82358ae
ToppCell	myeloid-Dendritic_cell-Plasmacytoid_dendritic_cell\|Dendritic_cell / Lineage, cell class and subclass	WNT10A PACSIN1 CIB2	1.16e-04	186	23	3	858134580a09ed8a5eb6d6413d8ca9265904dfc1
ToppCell	5'-Airway_Nasal-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	WNT10A PACSIN1 CIB2	1.16e-04	186	23	3	0096a61b1841784c913752b4f3639200446cc02c
ToppCell	5'-Airway_Nasal-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell-Plasmacytoid_DCs\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	WNT10A PACSIN1 CIB2	1.16e-04	186	23	3	9e159ad7289dcae2ec7ce655df746f46801b81d3
ToppCell	tumor_Lung-Myeloid_cells-pDCs\|Myeloid_cells / Location, Cell class and cell subclass	WNT10A PACSIN1 CIB2	1.16e-04	186	23	3	3d7c1a281fb82db4471283f39937007d889a5f38
ToppCell	5'-Airway_Nasal-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell-Plasmacytoid_DCs-Plasmacytoid_DCs_L.1.5.1.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	WNT10A PACSIN1 CIB2	1.16e-04	186	23	3	6345777847960c71a2ba3ce5a49c72c34ebd0e73
ToppCell	LAM-Lymphoid-pDC\|Lymphoid / Condition, Lineage and Cell class	PACSIN1 TRPM4 CIB2	1.18e-04	187	23	3	4d9ffd2bbdf1c9869e28991ce9331e4ccf3c0166
ToppCell	Leuk-UTI-Myeloid-pDC\|Leuk-UTI / Disease, Lineage and Cell Type	PACSIN1 PLS3 CIB2	1.18e-04	187	23	3	e3035b1f65ab12b8f01799b8e5d6633b9b584a06
ToppCell	control-pDC\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	PACSIN1 PLS3 CIB2	1.18e-04	187	23	3	c78aee98b32719aa45811b620fc97be1ecf5fd53
ToppCell	(0)_Myeloid-(011)_pDC\|(0)_Myeloid / immune cells in Peripheral Blood (logTPM normalization)	WNT10A PACSIN1 CIB2	1.20e-04	188	23	3	a81b5d840490d6a636fe168f8cff2c4984369f09
ToppCell	COVID-19_Mild-pDC\|COVID-19_Mild / Disease condition and Cell class	WNT10A PACSIN1 CIB2	1.20e-04	188	23	3	62d33d2990d4a2d32bd0863147e47f656df1966e
ToppCell	myeloid-pDC\|myeloid / Lineage and Cell class	WNT10A PACSIN1 CIB2	1.20e-04	188	23	3	a2dc4bbeca2bdc00c51825dd65a699c54c72f241
ToppCell	droplet-Kidney-nan-3m-Epithelial-Epcam____podocyte-2\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PABPC4L MISP CIB2	1.20e-04	188	23	3	c300accbac71a3bc075fe985543d8a8ead82531b
ToppCell	COVID-19_Mild-pDC-\|COVID-19_Mild / Disease condition and Cell class	WNT10A PACSIN1 CIB2	1.20e-04	188	23	3	a75c2cf2f8dae343c13aaa66b637658b935ed10a
ToppCell	Int-URO-Myeloid-pDC\|Int-URO / Disease, Lineage and Cell Type	WNT10A PACSIN1 CIB2	1.21e-04	189	23	3	37aee7a0acd5fd5dd62f22608d72ff8afe210e5c
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_II-Z\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	RIPOR3 FKBP4 PABPC3	1.23e-04	190	23	3	4d401b73c0e7eb38e95d0851a128bf12bb0d3a9f
ToppCell	Control\|World / Disease, Lineage and Cell Type	WNT10A PACSIN1 CIB2	1.23e-04	190	23	3	015a2703618710fd4a74f687f8b2bada586d99f4
ToppCell	Control-pDC-\|Control / Disease condition and Cell class	WNT10A PACSIN1 CIB2	1.25e-04	191	23	3	1d7b0fae4d114d6db933c18b4eb2066ffa61356d
ToppCell	Control-pDC\|Control / Disease condition and Cell class	WNT10A PACSIN1 CIB2	1.25e-04	191	23	3	543e1437a52d04436862dd1c27b4fae95c44fcc8
ToppCell	renal_papilla_nuclei-Adult_normal_reference\|renal_papilla_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group	MGAM RIPOR3 LRBA	1.27e-04	192	23	3	6c106b91e46eabbe686a52a65a9c94ad9cbe9390
ToppCell	control-pDC\|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	PACSIN1 PLS3 CIB2	1.29e-04	193	23	3	30a6559c9a9e8941861cb259b4836acccc427e68
ToppCell	medial-Hematologic-Plasmacytoid_Dendritic\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	WNT10A PACSIN1 CIB2	1.31e-04	194	23	3	bb36274d6fe2d18c545a17d3809f331586502d01
ToppCell	medial-2-Hematologic-Plasmacytoid_Dendritic\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	WNT10A PACSIN1 CIB2	1.31e-04	194	23	3	d58be6454a0795d6771036a1620553a153861615
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-DC-DC3\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	WNT10A PACSIN1 CIB2	1.31e-04	194	23	3	3f9e4a8e5699bc379e8a0d337e0daef09632e71c
ToppCell	medial-Hematologic-Plasmacytoid_Dendritic-2\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	WNT10A PACSIN1 CIB2	1.31e-04	194	23	3	0117cd68750153fd6b8978c8b4ce3589486d2b5f
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-DC-DC3-Z\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	WNT10A PACSIN1 CIB2	1.31e-04	194	23	3	5250736b608001fb73aa74dee8cb8465a1d2f372
ToppCell	10x_3'_v3-blood_(10x_3'_v3)-myeloid-myeloid_monocytic-classical_monocyte\|blood_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	GDI2 PABPC1 CAPNS1	1.35e-04	196	23	3	28e9e191361966df3a9bd48450090577aa72a999
ToppCell	Biopsy_Other_PF-Immune-pDCs\|Biopsy_Other_PF / Sample group, Lineage and Cell type	WNT10A PACSIN1 CIB2	1.37e-04	197	23	3	598a130eb7afb1bb95da64a964218362627feb49
ToppCell	mild-pDC\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	PACSIN1 PLS3 CIB2	1.37e-04	197	23	3	0cb00daa6943f7a7fb34a8fdf51188646af65686
ToppCell	Bronchial_Biopsy-Epithelial-Basal_1\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	WNT10A PABPC1 PLS3	1.37e-04	197	23	3	61c1c29a62d4c033999b7f0183c1e9cdd6a62925
ToppCell	Influenza-Influenza_Severe-Myeloid-pDC\|Influenza_Severe / Disease, condition lineage and cell class	PACSIN1 PLS3 CIB2	1.37e-04	197	23	3	e8e6f71e6dc8a695e4321a18543c1df63dd62f3e
ToppCell	distal-Hematologic-Plasmacytoid_Dendritic-3\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	WNT10A PACSIN1 CIB2	1.37e-04	197	23	3	3a5908deb5c5a2bf06019a102fb1652233cf2a2a
ToppCell	distal-1-Hematologic-Plasmacytoid_Dendritic\|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	WNT10A PACSIN1 CIB2	1.37e-04	197	23	3	166d47359df9279ea8c3946f10bd3d4b88c95857
ToppCell	Biopsy_IPF-Immune-pDCs\|Biopsy_IPF / Sample group, Lineage and Cell type	WNT10A PACSIN1 CIB2	1.39e-04	198	23	3	aa8943e6796f619406056cf763b751fe9a9a3e0c
ToppCell	Parenchymal-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_airway_ASM\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	MGAM RYR2 CIB2	1.39e-04	198	23	3	d1827e3707b929e3a3562989a0c11537d344e164
ToppCell	10x_3'_v3-blood_(10x_3'_v3)-myeloid-myeloid_monocytic\|blood_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	GDI2 PABPC1 CAPNS1	1.39e-04	198	23	3	f3346c26b9647a199faf3cd7ab19c3a963dbabc2
ToppCell	Sepsis-ICU-SEP-Myeloid-pDC\|ICU-SEP / Disease, condition lineage and cell class	PACSIN1 PLS3 CIB2	1.39e-04	198	23	3	fe8a68bff8c1b9566eee4bfcab564f206a20ae7b
ToppCell	distal-Hematologic-Plasmacytoid_Dendritic\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	WNT10A PACSIN1 CIB2	1.39e-04	198	23	3	bb03744d8372405c278a0781e2f513bed00cf2b3
ToppCell	Tracheal-NucSeq\|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations	USP34 LRBA ITPR2	1.41e-04	199	23	3	94b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCell	Sepsis-Int-URO-Myeloid-pDC\|Int-URO / Disease, condition lineage and cell class	WNT10A PACSIN1 CIB2	1.41e-04	199	23	3	a41c3c3360b1b4546c9b2c49bda595feef6a4a4a
ToppCell	Control-Control-Myeloid-pDC\|Control / Disease, condition lineage and cell class	WNT10A PACSIN1 CIB2	1.41e-04	199	23	3	8e9cac53fabe497ffa27fca0627eafe883af2534
ToppCell	distal-2-Hematologic-Plasmacytoid_Dendritic\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	WNT10A PACSIN1 CIB2	1.41e-04	199	23	3	78796b05d28b35e7361b6271d4a3858faa39c45c
ToppCell	Basal-basal-2\|World / Class top	WNT10A PABPC1 CAPNS1	1.41e-04	199	23	3	a728d8675d01f1b3143f06adfceca74d17f58477
ToppCell	COVID-19-COVID-19_Mild-Myeloid-pDC\|COVID-19_Mild / Disease, condition lineage and cell class	WNT10A PACSIN1 CIB2	1.41e-04	199	23	3	9de61e5189d907cc969ac3043d68204f70acc0bf
ToppCell	Sepsis-ICU-NoSEP-Myeloid-pDC\|ICU-NoSEP / Disease, condition lineage and cell class	WNT10A PACSIN1 CIB2	1.41e-04	199	23	3	a199e67438eeed903d0996605591ec54400fdd66
ToppCell	distal-Hematologic-Plasmacytoid_Dendritic-2\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	WNT10A PACSIN1 CIB2	1.44e-04	200	23	3	ef42753c9fbe3770e3f415cd7ab412654d359edb
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW16-Neuronal-Interneuron\|GW16 / Sample Type, Dataset, Time_group, and Cell type.	WNT10A PLS3	7.33e-04	78	23	2	8ad496ccbffb62a50f195c3789a95d8c80e2272d
ToppCell	Thalamus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Chrnb3_(interneuron,_Lateral_Geniculate_Nucleus__(LGN))--\|Thalamus / BrainAtlas - Mouse McCarroll V32	MGAM MISP	7.52e-04	79	23	2	5c37af70dca7e9847f44d7f5969d4b06c32b4ca0
ToppCell	Thalamus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Chrnb3_(interneuron,_Lateral_Geniculate_Nucleus__(LGN))-\|Thalamus / BrainAtlas - Mouse McCarroll V32	MGAM MISP	7.52e-04	79	23	2	d4f9297084aea33203dd98d7f6f837b6eb00b6c3
ToppCell	Thalamus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Chrnb3_(interneuron,_Lateral_Geniculate_Nucleus__(LGN))\|Thalamus / BrainAtlas - Mouse McCarroll V32	MGAM MISP	7.52e-04	79	23	2	75d8cbf8c7a6a4a825143f7d04a604e97bab0fe5
Drug	AC1L1IZ2	TRPM4 MGAM PLS3 RYR2 LRBA	1.13e-05	304	23	5	CID000004795
Drug	KS24	PABPC1 PABPC3	1.46e-05	6	23	2	CID000099135
Drug	pteridine analog	MGAM LRBA	2.04e-05	7	23	2	CID000160723
Drug	Levodopa [59-92-7]; Up 200; 20.2uM; HL60; HG-U133A	PACSIN1 MGAM MISP FKBP4	4.23e-05	197	23	4	1972_UP
Drug	AC1L1D8L	FKBP4 RYR2 PENK	4.92e-05	71	23	3	CID000002241
Drug	C13932	PACSIN1 TRPM4 MGAM RYR2	5.04e-05	206	23	4	CID000168297
Drug	Sub P	MGAM PENK	5.34e-05	11	23	2	CID003035700
Drug	A-Cw	MGAM LRBA	6.40e-05	12	23	2	CID013891726
Drug	x Ma	MGAM LRBA	6.40e-05	12	23	2	CID000446331
Drug	3-(1H-pyrrole-2-carboxylate	FKBP4 RYR2 CAPNS1 LRBA	8.12e-05	233	23	4	CID000005114
Drug	FPL 64176	RYR2 CAPNS1	1.02e-04	15	23	2	CID000003423
Drug	Ici 154129	CAPNS1 PENK	1.16e-04	16	23	2	CID003035055
Drug	methylcoumarin	RYR2 CAPNS1	1.48e-04	18	23	2	CID000007092
Drug	beryllium fluoride	MGAM PLS3 FKBP4	1.49e-04	103	23	3	CID000024589
Drug	AC1L380G	MGAM RYR2	1.65e-04	19	23	2	CID000084698
Drug	Baclofen	RYR2 PENK	1.83e-04	20	23	2	ctd:D001418
Drug	CGP7040	MGAM FKBP4	1.83e-04	20	23	2	CID006436259
Drug	silver hydride	MGAM LRBA	1.83e-04	20	23	2	CID000139654
Drug	lactobionic acid	MGAM LRBA	2.03e-04	21	23	2	CID000007314
Drug	Mgamp-pnp	MGAM PLS3	2.03e-04	21	23	2	CID005311323
Drug	Npys	CAPNS1 PENK	2.03e-04	21	23	2	CID000129283
Drug	taxol	GDI2 PACSIN1 PLS3 CAPNS1 PENK	2.06e-04	560	23	5	CID000004666
Drug	NSC406942	PABPC1 MGAM PLS3 RYR2 LRBA	2.15e-04	565	23	5	CID000001115
Drug	K-Cl	WNT10A MGAM PLS3 RYR2 PENK	2.18e-04	567	23	5	CID000004873
Drug	isocycloheximide	PABPC1 PLS3 FKBP4 CAPNS1 PENK LRBA	2.19e-04	905	23	6	CID000002900
Drug	D-myo-inositol-1,4,5-triphosphate	TRPM4 PLS3 RYR2 CAPNS1 LRBA	2.20e-04	568	23	5	CID000000806
Drug	noradrealine	ARVCF PLS3 RYR2 PENK LRBA	2.33e-04	575	23	5	CID000000951
Drug	Deltakephalin	CAPNS1 PENK	2.66e-04	24	23	2	CID000119319
Drug	BAPTA	GDI2 RYR2 CAPNS1 LRBA	2.88e-04	324	23	4	CID000104751
Drug	lanthanum	TRPM4 MGAM RYR2	3.38e-04	136	23	3	CID000023926
Drug	Lb I	FKBP4 LRBA	3.63e-04	28	23	2	CID000161844
Drug	LB-2	MGAM LRBA	3.63e-04	28	23	2	CID000129887
Drug	Kelatorphan	CAPNS1 PENK	4.17e-04	30	23	2	CID000123982
Drug	delta3-piperidine	CAPNS1 PENK	4.17e-04	30	23	2	CID000012750
Drug	Bay K 8644	MGAM RYR2 LRBA	4.51e-04	150	23	3	CID000002303
Drug	carbodiimide	MGAM PLS3 LRBA	4.59e-04	151	23	3	CID000009864
Drug	geldanamicin	PACSIN1 FKBP4 CAPNS1 PENK	4.90e-04	373	23	4	CID000003460
Drug	CaCl2	MGAM PLS3 CAPNS1	5.05e-04	156	23	3	CID000024854
Drug	RU 58668	FKBP4 CAPNS1	5.06e-04	33	23	2	CID000119604
Drug	glibenclamide	TRPM4 MGAM PENK LRBA	5.37e-04	382	23	4	CID000003488
Drug	1,N6-ethenoadenosine 5'-diphosphate	MGAM PLS3	5.37e-04	34	23	2	CID000001312
Drug	calmidazolium chloride	CAPNS1 PENK LRBA	5.44e-04	160	23	3	CID000002531
Drug	NSC717865	GDI2 PLS3 FKBP4 RYR2	5.63e-04	387	23	4	CID000005372
Drug	chlorothalonil	PACSIN1 FKBP4 PENK	5.64e-04	162	23	3	CID000015910
Drug	(2S,3R)-Sphingosine	PLS3 RYR2 PENK LRBA	5.74e-04	389	23	4	CID000001104
Drug	MG-262; Up 200; 0.1uM; PC3; HT_HG-U133A	FKBP4 CIB2 ITPR2	5.85e-04	164	23	3	7079_UP
Drug	pMDI	MGAM PLS3	6.02e-04	36	23	2	CID000007570
Drug	mag-fura-2	MGAM RYR2	6.36e-04	37	23	2	CID000123839
Drug	AC1L1BDQ	TRPM4 PLS3 LRBA	6.83e-04	173	23	3	CID000001394
Drug	3-nitropropionic acid	PACSIN1 CAPNS1 PENK	7.42e-04	178	23	3	CID000001678
Drug	L000369	TRPM4 PENK	7.81e-04	41	23	2	CID003931705
Drug	epsilon-ATP	MGAM PLS3	7.81e-04	41	23	2	CID000162262
Drug	NSC7524	MGAM RYR2 PENK	7.91e-04	182	23	3	CID000005657
Drug	Thiostrepton [1393-48-2]; Up 200; 2.4uM; HL60; HT_HG-U133A	FKBP4 CIB2 ITPR2	8.16e-04	184	23	3	2462_UP
Drug	CTK8G2960	PACSIN1 FKBP4 PENK	8.42e-04	186	23	3	CID005361912
Drug	calphostin C	TRPM4 PLS3 CAPNS1 LRBA	8.43e-04	431	23	4	CID000002533
Drug	arabinosyladenine	PABPC1 MGAM PLS3 RYR2 LRBA	8.44e-04	762	23	5	CID000000191
Drug	17-AAG; Up 200; 1uM; PC3; HT_HG-U133A	TRPM4 FKBP4 CIB2	8.55e-04	187	23	3	5958_UP
Drug	Lovastatin [75330-75-5]; Up 200; 9.8uM; MCF7; HT_HG-U133A	ARVCF USP34 PACSIN1	8.69e-04	188	23	3	2854_UP
Drug	ATP,Gamma S	TRPM4 MGAM LRBA	8.82e-04	189	23	3	CID000002028
Drug	Apigenin [520-36-5]; Up 200; 14.8uM; MCF7; HT_HG-U133A	ARVCF MGAM RYR2	8.96e-04	190	23	3	3257_UP
Drug	Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; HL60; HG-U133A	ARVCF MGAM LRBA	8.96e-04	190	23	3	1971_UP
Drug	thapsigargin; Down 200; 0.1uM; MCF7; HT_HG-U133A	ARVCF TRPM4 MISP	9.09e-04	191	23	3	7100_DN
Drug	AC1L96VB	TRPM4 RYR2 CAPNS1	9.09e-04	191	23	3	CID000439200
Drug	Alsterpaullone; Up 200; 10uM; PC3; HT_HG-U133A	CIB2 LRBA ITPR2	9.09e-04	191	23	3	7078_UP
Drug	Cetirizine dihydrochloride [83881-52-1]; Up 200; 8.6uM; MCF7; HT_HG-U133A	ARVCF PACSIN1 TRPM4	9.37e-04	193	23	3	2829_UP
Drug	cellopentaose	MGAM LRBA	9.41e-04	45	23	2	CID000440949
Drug	Promethazine hydrochloride [58-33-3]; Up 200; 12.4uM; HL60; HT_HG-U133A	ARVCF PENK ITPR2	9.51e-04	194	23	3	3100_UP
Drug	2-deoxy-D-glucose; Down 200; 10000uM; MCF7; HG-U133A	ARVCF PACSIN1 ITPR2	9.51e-04	194	23	3	344_DN
Drug	Bufexamac [2438-72-4]; Up 200; 18uM; MCF7; HT_HG-U133A	ARVCF USP34 PACSIN1	9.51e-04	194	23	3	7413_UP
Drug	pioglitazone HCl; Up 200; 10uM; MCF7; HT_HG-U133A	ARVCF RYR2 ITPR2	9.51e-04	194	23	3	7523_UP
Drug	Karakoline [39089-30-0]; Down 200; 10.6uM; MCF7; HT_HG-U133A	USP34 TRPM4 RYR2	9.66e-04	195	23	3	6059_DN
Drug	Heliotrine [303-33-3]; Down 200; 12.8uM; MCF7; HT_HG-U133A	ARVCF TRPM4 ITPR2	9.66e-04	195	23	3	6035_DN
Drug	Testosterone propionate [57-85-2]; Up 200; 11.6uM; MCF7; HT_HG-U133A	ARVCF TRPM4 ITPR2	9.66e-04	195	23	3	5636_UP
Drug	Scopoletin [92-61-5]; Down 200; 20.8uM; MCF7; HT_HG-U133A	USP34 TRPM4 RYR2	9.66e-04	195	23	3	6510_DN
Drug	pioglitazone HCl; Down 200; 10uM; MCF7; HT_HG-U133A	ARVCF USP34 TRPM4	9.80e-04	196	23	3	7083_DN
Drug	Alfuzosin hydrochloride [81403-68-1]; Up 200; 9.4uM; PC3; HT_HG-U133A	MGAM RYR2 PENK	9.80e-04	196	23	3	4644_UP
Drug	LY 294002; Down 200; 0.1uM; PC3; HT_HG-U133A	USP34 CIB2 ITPR2	9.80e-04	196	23	3	1216_DN
Drug	Amphotericin B [1397-89-3]; Down 200; 4.4uM; MCF7; HT_HG-U133A	ARVCF TRPM4 RYR2	9.80e-04	196	23	3	5404_DN
Drug	Edrophonium chloride [116-38-1]; Up 200; 19.8uM; HL60; HG-U133A	ARVCF PACSIN1 FKBP4	9.80e-04	196	23	3	2019_UP
Drug	Methylhydantoin-5-(D) [55147-68-7]; Up 200; 35uM; PC3; HT_HG-U133A	ARVCF CIB2 ITPR2	9.80e-04	196	23	3	3994_UP
Drug	Ceforanide [60925-61-3]; Up 200; 7.6uM; HL60; HT_HG-U133A	ARVCF RYR2 CIB2	9.80e-04	196	23	3	2447_UP
Drug	AC1L3R33	MGAM FKBP4	9.83e-04	46	23	2	CID000145386
Drug	withaferin A	PLS3 LRBA	9.83e-04	46	23	2	CID000265237
Drug	estradiol, USP; Down 200; 0.1uM; HL60; HT_HG-U133A	USP34 RYR2 ITPR2	9.94e-04	197	23	3	2668_DN
Drug	Ajmaline [4360-12-7]; Up 200; 12.2uM; MCF7; HT_HG-U133A	TRPM4 RYR2 ITPR2	9.94e-04	197	23	3	7484_UP
Drug	Calciferol [50-14-6]; Up 200; 10uM; MCF7; HT_HG-U133A	ARVCF PACSIN1 ITPR2	9.94e-04	197	23	3	3304_UP
Drug	Oxyphenbutazone [129-20-4]; Down 200; 12.4uM; MCF7; HT_HG-U133A	ARVCF PACSIN1 RYR2	9.94e-04	197	23	3	3582_DN
Drug	Pirenzepine dihydrochloride [29868-97-1]; Up 200; 9.4uM; MCF7; HT_HG-U133A	ARVCF PACSIN1 PENK	1.01e-03	198	23	3	2234_UP
Drug	Clorsulon [60200-06-8]; Up 200; 10.6uM; HL60; HG-U133A	USP34 PACSIN1 PENK	1.01e-03	198	23	3	1735_UP
Drug	Niridazole [61-57-4]; Up 200; 18.6uM; MCF7; HT_HG-U133A	USP34 PACSIN1 RYR2	1.01e-03	198	23	3	5682_UP
Drug	Nitrendipine [39562-70-4]; Down 200; 11uM; MCF7; HT_HG-U133A	ARVCF USP34 RYR2	1.01e-03	198	23	3	5405_DN
Drug	Dydrogesterone [152-62-5]; Up 200; 12.8uM; MCF7; HT_HG-U133A	ARVCF RYR2 CIB2	1.01e-03	198	23	3	2811_UP
Drug	Riboflavine [83-88-5]; Up 200; 10.6uM; MCF7; HT_HG-U133A	ARVCF PACSIN1 ITPR2	1.01e-03	198	23	3	2760_UP
Drug	Mephenesin [59-47-2]; Down 200; 22uM; MCF7; HT_HG-U133A	ARVCF TRPM4 RYR2	1.01e-03	198	23	3	4698_DN
Disease	22q11 partial monosomy syndrome	ARVCF RREB1	1.90e-05	9	22	2	C3266101
Disease	Asymmetric crying face association	ARVCF RREB1	2.38e-05	10	22	2	C0431406
Disease	22q11 Deletion Syndrome	ARVCF RREB1	2.38e-05	10	22	2	C2936346
Disease	DiGeorge Syndrome	ARVCF RREB1	6.33e-05	16	22	2	C0012236
Disease	CONOTRUNCAL ANOMALY FACE SYNDROME	ARVCF RREB1	6.33e-05	16	22	2	C0795907
Disease	Shprintzen syndrome	ARVCF RREB1	6.33e-05	16	22	2	C0220704
Disease	platelet component distribution width	ING5 ARVCF PACSIN1 PLS3 RIPOR3	1.98e-04	755	22	5	EFO_0007984
Disease	Huntington's disease (implicated_via_orthology)	PACSIN1 PLS3	2.60e-04	32	22	2	DOID:12858 (implicated_via_orthology)
Disease	lymphocyte count	ARVCF PACSIN1 RIPOR3 GIMAP8 ITPR2 RREB1	5.54e-04	1464	22	6	EFO_0004587
Disease	FEV/FEC ratio	ARVCF USP34 PABPC4L MGAM RREB1	1.80e-03	1228	22	5	EFO_0004713
Disease	vital capacity	USP34 FKBP4 RYR2 LRBA RREB1	1.86e-03	1236	22	5	EFO_0004312
Disease	neutrophil count	ARVCF RIPOR3 LRBA ITPR2 RREB1	3.02e-03	1382	22	5	EFO_0004833
Disease	birth weight	PABPC4L ITPR2 RREB1	3.12e-03	399	22	3	EFO_0004344

Protein segments in the cluster

Peptide	Gene	Start	Entry
KKDGEMDRNFDTLDL	ARVCF	631	O00192
FKEKAGEGSMLRLED	ITPR2	526	Q14571
KNFGEDMDDERLKDL	PABPC1	196	P11940
DMDDERLKDLFGKFG	PABPC1	201	P11940
YGGFMKKDAEEDDSL	PENK	136	P01210
GEDKEMKTYRLDAGD	MISP	116	Q8IVT2
GSEFDFEEMKRKKND	GDI2	426	P50395
RQKFMGFKIALDDEG	MGAM	2626	O43451
MLDGDRNKDGKISFD	PLS3	61	P13797
AGEKLDMFGNDDKLI	LRBA	1141	P50851
KNFGEDMDDERLKDL	PABPC3	196	Q9H361
DMDDERLKDLFGKFG	PABPC3	201	Q9H361
MGGFKETKEAEDGFR	PACSIN1	126	Q9BY11
LDAMFRAFKSLDKDG	CAPNS1	236	P04632
RKEDLGAGNLEDFMK	GIMAP8	566	Q8ND71
RFEADLKDKMEGSDF	ING5	106	Q8WYH8
LDRKDKFSFDLGKGE	FKBP4	71	Q02790
GMDKAALDFSDAREK	RYR2	4671	Q92736
NFGGDMDDERLKDVF	PABPC4L	196	P0CB38
DGKLGFADFEDMIAK	CIB2	161	O75838
LSFGEKGRLAFEKMD	RIPOR3	911	Q96MK2
ATKLMDFKLAEGDGE	RREB1	1366	Q92766
DFLMGKSERKEGFKE	USP34	2121	Q70CQ2
PDMGFGERFSKDFLD	WNT10A	216	Q9GZT5
RRKDLAFKFEGMGVD	TRPM4	611	Q8TD43