Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ATP hydrolysis activity	ATP11B ABCA5 SMC3 ABCC8 RECQL5 CHD1 CHD2 RFC5 DDX10	8.92e-05	441	83	9	GO:0016887
GeneOntologyMolecularFunction	ribonucleoside triphosphate phosphatase activity	ATP11B ABCA5 SMC3 ABCC8 RECQL5 CHD1 CHD2 RFC5 RGS16 DDX10 SEPTIN2	3.54e-04	775	83	11	GO:0017111
GeneOntologyMolecularFunction	helicase activity	RECQL5 CHD1 CHD2 RFC5 DDX10	5.14e-04	158	83	5	GO:0004386
GeneOntologyMolecularFunction	pyrophosphatase activity	ATP11B ABCA5 SMC3 ABCC8 RECQL5 CHD1 CHD2 RFC5 RGS16 DDX10 SEPTIN2	6.88e-04	839	83	11	GO:0016462
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides	ATP11B ABCA5 SMC3 ABCC8 RECQL5 CHD1 CHD2 RFC5 RGS16 DDX10 SEPTIN2	6.95e-04	840	83	11	GO:0016817
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	ATP11B ABCA5 SMC3 ABCC8 RECQL5 CHD1 CHD2 RFC5 RGS16 DDX10 SEPTIN2	6.95e-04	840	83	11	GO:0016818
Domain	DUF4208	CHD1 CHD2	5.98e-05	3	84	2	PF13907
Domain	DUF4208	CHD1 CHD2	5.98e-05	3	84	2	SM01176
Domain	DUF4208	CHD1 CHD2	5.98e-05	3	84	2	IPR025260
Domain	-	ORC5 NLRP9 ABCA5 SMC3 ABCC8 RECQL5 CHD1 CHD2 RFC5 CNP DDX10 SEPTIN2	1.22e-04	746	84	12	3.40.50.300
Domain	P-loop_NTPase	ORC5 NLRP9 ABCA5 SMC3 ABCC8 RECQL5 CHD1 CHD2 RFC5 CNP DDX10 SEPTIN2	3.95e-04	848	84	12	IPR027417
Domain	DNA/RNA_helicase_DEAH_CS	RECQL5 CHD1 CHD2	5.18e-04	35	84	3	IPR002464
Domain	-	CPA2 CPA3	5.50e-04	8	84	2	3.30.70.340
Domain	Propep_M14	CPA2 CPA3	5.50e-04	8	84	2	PF02244
Domain	M14A_act_pep	CPA2 CPA3	5.50e-04	8	84	2	IPR003146
Domain	DEAH_ATP_HELICASE	RECQL5 CHD1 CHD2	6.61e-04	38	84	3	PS00690
Domain	Tyr_kinase_rcpt_2_CS	NTRK2 INSRR	1.07e-03	11	84	2	IPR002011
Domain	RECEPTOR_TYR_KIN_II	NTRK2 INSRR	1.28e-03	12	84	2	PS00239
Domain	Helicase_C	RECQL5 CHD1 CHD2 DDX10	1.38e-03	107	84	4	PF00271
Domain	HELICc	RECQL5 CHD1 CHD2 DDX10	1.38e-03	107	84	4	SM00490
Domain	Helicase_C	RECQL5 CHD1 CHD2 DDX10	1.43e-03	108	84	4	IPR001650
Domain	HELICASE_CTER	RECQL5 CHD1 CHD2 DDX10	1.48e-03	109	84	4	PS51194
Domain	HELICASE_ATP_BIND_1	RECQL5 CHD1 CHD2 DDX10	1.48e-03	109	84	4	PS51192
Domain	DEXDc	RECQL5 CHD1 CHD2 DDX10	1.48e-03	109	84	4	SM00487
Domain	Helicase_ATP-bd	RECQL5 CHD1 CHD2 DDX10	1.53e-03	110	84	4	IPR014001
Domain	Propept_inh	CPA2 CPA3	2.60e-03	17	84	2	IPR009020
Domain	Chromodomain_CS	CHD1 CHD2	2.92e-03	18	84	2	IPR023779
Domain	Zn_pept	CPA2 CPA3	2.92e-03	18	84	2	SM00631
Domain	CARBOXYPEPT_ZN_2	CPA2 CPA3	3.25e-03	19	84	2	PS00133
Domain	CARBOXYPEPT_ZN_1	CPA2 CPA3	3.60e-03	20	84	2	PS00132
Domain	Peptidase_M14	CPA2 CPA3	4.76e-03	23	84	2	PF00246
Domain	Peptidase_M14	CPA2 CPA3	4.76e-03	23	84	2	IPR000834
Domain	Chromo_domain	CHD1 CHD2	5.17e-03	24	84	2	IPR023780
Domain	KRAB	ZNF560 ZNF559 ZNF596 ZFP1 ZNF737 ZNF99	5.52e-03	358	84	6	PS50805
Domain	KRAB	ZNF560 ZNF559 ZNF596 ZFP1 ZNF737 ZNF99	5.52e-03	358	84	6	PF01352
Domain	Chromo	CHD1 CHD2	6.06e-03	26	84	2	PF00385
Domain	KRAB	ZNF560 ZNF559 ZNF596 ZFP1 ZNF737 ZNF99	6.37e-03	369	84	6	SM00349
Domain	KRAB	ZNF560 ZNF559 ZNF596 ZFP1 ZNF737 ZNF99	6.45e-03	370	84	6	IPR001909
Domain	CHROMO_1	CHD1 CHD2	7.00e-03	28	84	2	PS00598
Domain	CHROMO_2	CHD1 CHD2	7.00e-03	28	84	2	PS50013
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	ORC5 SMC3 PTBP2 RECQL5 NIP7 ZFP1 ZBTB10 CHD1 CHD2 RFC5 SPEN DDX10	3.01e-08	608	85	12	36089195
Pubmed	The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells.	TNPO1 SMC3 USP9X NIP7 ZBTB10 SSB SPEN CNP	4.74e-07	282	85	8	23667531
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	TNPO1 NOLC1 RBM45 P4HB PTBP2 SAP18 MRPL44 NIP7 CHD2 SSB SPEN DDX10	6.27e-07	807	85	12	22681889
Pubmed	Human transcription factor protein interaction networks.	NOLC1 SMC3 P4HB USP9X MRPL44 RECQL5 NIP7 ZBTB10 SMARCD3 IRF2BPL SSB SPEN TRAPPC9 SLX4 DDX10	1.79e-06	1429	85	15	35140242
Pubmed	CHD1 and CHD2 are positive regulators of HIV-1 gene expression.	CHD1 CHD2	5.90e-06	2	85	2	25297984
Pubmed	TrkB Agonist LM22A-4 Increases Oligodendroglial Populations During Myelin Repair in the Corpus Callosum.	NTRK2 CNP	5.90e-06	2	85	2	31507374
Pubmed	Usp9y (ubiquitin-specific protease 9 gene on the Y) is associated with a functional promoter and encodes an intact open reading frame homologous to Usp9x that is under selective constraint.	USP9X USP9Y	5.90e-06	2	85	2	12925892
Pubmed	Ubiquitin-specific protease activity of USP9Y, a male infertility gene on the Y chromosome.	USP9X USP9Y	5.90e-06	2	85	2	12895410
Pubmed	The Drosophila developmental gene fat facets has a human homologue in Xp11.4 which escapes X-inactivation and has related sequences on Yq11.2.	USP9X USP9Y	5.90e-06	2	85	2	8922996
Pubmed	Development of a deer mouse whole-genome radiation hybrid panel and comparative mapping of Mus chromosome 11 loci.	P4HB SCN4A UGP2	1.12e-05	18	85	3	16416089
Pubmed	ZBTB2 protein is a new partner of the Nucleosome Remodeling and Deacetylase (NuRD) complex.	NOLC1 P4HB SAP18 NIP7 ZBTB10 CHD1 DDX10	1.70e-05	330	85	7	33301849
Pubmed	Targeted inactivation of the Septin2 and Septin9 genes in myelinating Schwann cells of mice.	CNP SEPTIN2	1.77e-05	3	85	2	36378242
Pubmed	Targeting TrkB with a Brain-Derived Neurotrophic Factor Mimetic Promotes Myelin Repair in the Brain.	NTRK2 CNP	1.77e-05	3	85	2	29976621
Pubmed	Phosphorylation of aryl hydrocarbon receptor interacting protein by TBK1 negatively regulates IRF7 and the type I interferon response.	TBK1 AHR	1.77e-05	3	85	2	38043800
Pubmed	TBK1 Knockdown Alleviates Axonal Transport Deficits in Retinal Ganglion Cells Via mTORC1 Activation in a Retinal Damage Mouse Model.	USP9X TBK1	1.77e-05	3	85	2	37395713
Pubmed	CHD1 and SPOP synergistically protect prostate epithelial cells from DNA damage.	CHD1 CHD2	1.77e-05	3	85	2	33022763
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	NOLC1 CHD1 GREB1 RFC5 KAT6B SPEN DDX10	2.10e-05	341	85	7	32971831
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	TNPO1 NOLC1 P4HB USP9X CHD1 CHD2 SSB SPEN DDX10	3.18e-05	653	85	9	22586326
Pubmed	Characterization of the CHD family of proteins.	CHD1 CHD2	3.53e-05	4	85	2	9326634
Pubmed	Molecular Tuning of the Axonal Mitochondrial Ca2+ Uniporter Ensures Metabolic Flexibility of Neurotransmission.	MICU3 MCU	3.53e-05	4	85	2	31862210
Pubmed	MICU2, a paralog of MICU1, resides within the mitochondrial uniporter complex to regulate calcium handling.	MICU3 MCU	3.53e-05	4	85	2	23409044
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	TNPO1 NOLC1 SMC3 P4HB USP9X TBK1 CHD1 RFC5 SPEN CNP DDX10	3.99e-05	1024	85	11	24711643
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	TNPO1 NOLC1 SMC3 P4HB USP9X TBK1 MRPL44 CHD1 SSB RFC5 SPEN DDX10 SEPTIN2	4.12e-05	1425	85	13	30948266
Pubmed	TrkB regulates neocortex formation through the Shc/PLCgamma-mediated control of neuronal migration.	NTRK2 CNP	5.87e-05	5	85	2	15372074
Pubmed	Purification and properties of five different forms of human procarboxypeptidases.	CPA2 CPA3	5.87e-05	5	85	2	2920728
Pubmed	HIF-1 recruits NANOG as a coactivator for TERT gene transcription in hypoxic breast cancer stem cells.	USP9X TERT	5.87e-05	5	85	2	34592152
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	TNPO1 NOLC1 RBM45 P4HB PTBP2 SAP18 MRPL44 SMARCD3 CHD2 USP9Y SPEN	6.54e-05	1082	85	11	38697112
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	NOLC1 SMC3 SAP18 MCU NIP7 CHD1 CHD2 SSB PIP4K2C RFC5 TERT DDX10	8.54e-05	1318	85	12	30463901
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	NOLC1 SPAM1 TBK1 ZFP1 ZBTB10 AHR SMARCD3 PIP4K2C RFC5 KAT6B SIRT5	8.61e-05	1116	85	11	31753913
Pubmed	CYLD Regulates Centriolar Satellites Proteostasis by Counteracting the E3 Ligase MIB1.	TNPO1 P4HB SSB RFC5 SEPTIN2	8.68e-05	182	85	5	31067453
Pubmed	Ankyrin-B regulates Kir6.2 membrane expression and function in heart.	ABCC8 NTRK2	8.80e-05	6	85	2	20610380
Pubmed	Genome-wide association study of bipolar disorder in European American and African American individuals.	BTBD16 NTRK2	1.64e-04	8	85	2	19488044
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	TNPO1 SMC3 P4HB PTBP2 USP9X SSB CNP SEPTIN2	1.71e-04	638	85	8	33239621
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	NOLC1 KIAA0825 P4HB PTBP2 CIAO3 SCN4A NIP7 UGP2 CC2D1B CHD2 SPEN ERICH6	1.97e-04	1442	85	12	35575683
Pubmed	TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.	TNPO1 SMC3 ZBTB10 IRF2BPL SSB	2.10e-04	220	85	5	35785414
Pubmed	ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents.	NOLC1 ORC5 SMC3 SAP18 NIP7 RFC5 CNP SEPTIN2	2.15e-04	660	85	8	32780723
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	KIAA0825 SMC3 USP9X CHD2 USP9Y RFC5 ZNF99	2.20e-04	497	85	7	36774506
Pubmed	Misregulation of Alternative Splicing in a Mouse Model of Rett Syndrome.	SMC3 SAP18 SMARCD3	2.39e-04	49	85	3	27352031
Pubmed	The neuropeptide neuromedin U stimulates innate lymphoid cells and type 2 inflammation.	CPA3 NMU	2.62e-04	10	85	2	28869965
Pubmed	Uncontrolled mitochondrial calcium uptake underlies the pathogenesis of neurodegeneration in MICU1-deficient mice and patients.	MICU3 MCU	2.62e-04	10	85	2	35302860
Pubmed	Expression and localization of Inter-alpha Inhibitors in rodent brain.	ITIH1 CNP	2.62e-04	10	85	2	26964679
Pubmed	Generation of GABAergic and dopaminergic interneurons from endogenous embryonic olfactory bulb precursor cells.	NTRK2 SV2C	2.62e-04	10	85	2	17038521
Pubmed	Characterisation of the coding sequence and fine mapping of the human DFFRY gene and comparative expression analysis and mapping to the Sxrb interval of the mouse Y chromosome of the Dffry gene.	USP9X USP9Y	2.62e-04	10	85	2	9384609
Pubmed	Large-scale mapping of human protein-protein interactions by mass spectrometry.	NOLC1 SMC3 P4HB SAP18 USP9X MRPL44 UGP2 CHD1 SSB RFC5 SEPTIN2	2.91e-04	1284	85	11	17353931
Pubmed	Cloning of the genes encoding two murine and human cochlear unconventional type I myosins.	USP9X SPEN	3.20e-04	11	85	2	9119401
Pubmed	Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.	NOLC1 SAP18 CHD1 CHD2 PIP4K2C RFC5 DDX10	3.36e-04	533	85	7	30554943
Pubmed	Proteomic analysis of exosomes from human neural stem cells by flow field-flow fractionation and nanoflow liquid chromatography-tandem mass spectrometry.	TNPO1 GREB1 PIP4K2C	3.37e-04	55	85	3	18570454
Pubmed	Loss of Usp9x disrupts cortical architecture, hippocampal development and TGFβ-mediated axonogenesis.	USP9X USP9Y	3.83e-04	12	85	2	23861879
Pubmed	Prohibitin 1 regulates tumor cell apoptosis via the interaction with X-linked inhibitor of apoptosis protein.	SMC3 P4HB PTBP2 MRPL44 SSB USP9Y RFC5 CNP	4.03e-04	725	85	8	27025967
Pubmed	Characterizing ZC3H18, a Multi-domain Protein at the Interface of RNA Production and Destruction Decisions.	NOLC1 SMC3 P4HB SAP18 NIP7 SSB SPEN DDX10	4.25e-04	731	85	8	29298432
Pubmed	Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma.	P4HB PTBP2 PPFIBP2 UGP2 SSB RFC5 ITIH1 SEPTIN2	4.29e-04	732	85	8	34732716
Pubmed	SNIP1 Recruits TET2 to Regulate c-MYC Target Genes and Cellular DNA Damage Response.	NOLC1 SAP18 NIP7 KAT6B DDX10	4.45e-04	259	85	5	30404004
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	NOLC1 SMC3 P4HB RECQL5 ZBTB10 CHD1 CHD2 PIP4K2C RFC5 CNP DDX10	4.52e-04	1353	85	11	29467282
Pubmed	Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins.	ABCA5 CSMD3 TRAPPC9	5.03e-04	63	85	3	11572484
Pubmed	MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity.	SMC3 CIAO3 RFC5 CNP	5.13e-04	150	85	4	22678362
Pubmed	SHLD2/FAM35A co-operates with REV7 to coordinate DNA double-strand break repair pathway choice.	ORC5 SMC3 MCU CHD2	5.13e-04	150	85	4	30154076
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	TNPO1 NOLC1 ORC5 RBM45 SMC3 PTBP2 RFC5	5.67e-04	582	85	7	20467437
Pubmed	Nucleolar proteome dynamics.	SMC3 SAP18 NIP7 RFC5 DDX10 SEPTIN2	5.79e-04	419	85	6	15635413
Pubmed	Deubiquitinating enzymes: a new class of biological regulators.	USP9X USP9Y	6.07e-04	15	85	2	9827704
Pubmed	Evolutionary strata on the mouse X chromosome correspond to strata on the human X chromosome.	USP9X USP9Y	6.07e-04	15	85	2	14762062
Pubmed	A yeast two-hybrid screen reveals that osteopontin associates with MAP1A and MAP1B in addition to other proteins linked to microtubule stability, apoptosis and protein degradation in the human brain.	CC2D1B CHD1 SSB	6.30e-04	68	85	3	22779921
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	NOLC1 SMC3 P4HB USP9X NIP7 CHD1 SSB PIP4K2C RFC5 SIRT5 CNP	6.56e-04	1415	85	11	28515276
Pubmed	TRIM28-mediated nucleocapsid protein SUMOylation enhances SARS-CoV-2 virulence.	NOLC1 SMC3 NIP7 CHD1 SSB DDX10	6.62e-04	430	85	6	38172120
Pubmed	Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS.	TNPO1 NOLC1 SAP18 USP9X PIP4K2C USP9Y	6.79e-04	432	85	6	23455922
Pubmed	HSP27 and HSP70 interact with CD10 in C4-2 prostate cancer cells.	TNPO1 NOLC1 MRPL44	6.85e-04	70	85	3	17342744
Pubmed	Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells.	ZNF737 ZNF99	6.93e-04	16	85	2	8467795
Pubmed	Disease mutant analysis identifies a new function of DAXX in telomerase regulation and telomere maintenance.	NOLC1 TERT	6.93e-04	16	85	2	25416818
Pubmed	Targeting USP9X-AMPK Axis in ARID1A-Deficient Hepatocellular Carcinoma.	USP9X SMARCD3	6.93e-04	16	85	2	35390516
Pubmed	A strategy for modulation of enzymes in the ubiquitin system.	USP9X USP9Y	7.84e-04	17	85	2	23287719
Pubmed	Wnt regulation: exploring Axin-Disheveled interactions and defining mechanisms by which the SCF E3 ubiquitin ligase is recruited to the destruction complex.	TNPO1 SMC3 P4HB TBK1 MRPL44 SSB RFC5 SEPTIN2	8.24e-04	809	85	8	32129710
Pubmed	Proteolysis of fibrillin-2 microfibrils is essential for normal skeletal development.	GDF5 ADAMTS6	8.80e-04	18	85	2	35503090
Pubmed	Sex differences in sex chromosome gene expression in mouse brain.	USP9X USP9Y	8.80e-04	18	85	2	12023983
Pubmed	Cancer-associated FBXW7 loss is synthetic lethal with pharmacological targeting of CDC7.	CIAO3 USP9X RFC5 DDX10	9.13e-04	175	85	4	37866880
Pubmed	Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.	TNPO1 NOLC1 SMC3 P4HB SAP18 PPFIBP2 TBK1 AHR SSB RFC5	9.26e-04	1247	85	10	27684187
Pubmed	A protein interaction landscape of breast cancer.	SAP18 USP9X MCU AHR SMARCD3 PIP4K2C CNP	9.36e-04	634	85	7	34591612
Pubmed	Comparative transcription map of the wobbler critical region on mouse chromosome 11 and the homologous region on human chromosome 2p13-14.	UGP2 PEX13	9.83e-04	19	85	2	12174196
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	TNPO1 NOLC1 SMC3 P4HB SAP18 NIP7 RFC5 SPEN CNP SEPTIN2	9.83e-04	1257	85	10	36526897
Pubmed	Sequential genome-wide CRISPR-Cas9 screens identify genes regulating cell-surface expression of tetraspanins.	GDF5 MICU3 ZNF559 INSRR UGP2 SSB ITIH1 SLX4	9.86e-04	832	85	8	36724073
Pubmed	Comparative interactome analysis of α-arrestin families in human and Drosophila.	NOLC1 ATP11B SAP18 USP9X SPEN	1.04e-03	313	85	5	38270169
Pubmed	Genetic evidence of the programming of beta cell mass and function by glucocorticoids in mice.	ABCC8 CPA2	1.09e-03	20	85	2	20857084
Pubmed	Two-Dimensional Fractionation Method for Proteome-Wide Cross-Linking Mass Spectrometry Analysis.	TNPO1 SMC3 PTBP2 USP9X SMARCD3 PIP4K2C RFC5 SEPTIN2	1.11e-03	847	85	8	35235311
Pubmed	Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.	SMC3 SAP18 NIP7 ZBTB10 IRF2BPL CHD1 SSB RFC5	1.11e-03	847	85	8	35850772
Pubmed	An improved method for the synthesis of cellulose membrane-bound peptides with free C termini is useful for PDZ domain binding studies.	ADAMTS6 SCN4A NMU	1.16e-03	84	85	3	15123239
Pubmed	The Deubiquitinase USP37 Regulates Chromosome Cohesion and Mitotic Progression.	SMC3 SAP18 SPEN	1.16e-03	84	85	3	26299517
Pubmed	Proteomic analysis of the epidermal growth factor receptor (EGFR) interactome and post-translational modifications associated with receptor endocytosis in response to EGF and stress.	ORC5 SMC3 TBK1 RFC5 CNP	1.20e-03	323	85	5	24797263
Pubmed	Proteomic analysis of steady-state nuclear hormone receptor coactivator complexes.	SAP18 TBK1 IRF2BPL	1.20e-03	85	85	3	16051665
Pubmed	Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.	TNPO1 UGP2 PEX13 SMARCD3 SPEN	1.30e-03	329	85	5	17474147
Pubmed	CHK2-BRCA1 tumor-suppressor axis restrains oncogenic Aurora-A kinase to ensure proper mitotic microtubule assembly.	TNPO1 NOLC1 SMC3 P4HB SSB SEPTIN2	1.35e-03	494	85	6	26831064
Pubmed	In vitro nuclear interactome of the HIV-1 Tat protein.	ORC5 SMC3 SAP18 SPEN	1.36e-03	195	85	4	19454010
Pubmed	Myosin-X recruits lamellipodin to filopodia tips.	NOLC1 USP9X UGP2	1.37e-03	89	85	3	36861887
Pubmed	Detection of genes regulated by Lmx1b during limb dorsalization.	GDF5 INSYN2B	1.44e-03	23	85	2	22417325
Pubmed	Identification of ten loci associated with height highlights new biological pathways in human growth.	GDF5 ANKFN1	1.44e-03	23	85	2	18391950
Pubmed	Proteomics analysis of the estrogen receptor alpha receptosome.	SMC3 P4HB SEPTIN2	1.56e-03	93	85	3	20348541
Pubmed	hnRNPA1 couples nuclear export and translation of specific mRNAs downstream of FGF-2/S6K2 signalling.	GDF5 P4HB USP9X MRPL44 SSB	1.62e-03	346	85	5	25324306
Pubmed	A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain.	RBM45 PTBP2 MRPL44 SSB SPEN	1.64e-03	347	85	5	16033648
Pubmed	Stabilization of the methyl-CpG binding protein ZBTB38 by the deubiquitinase USP9X limits the occurrence and toxicity of oxidative stress in human cells.	TNPO1 USP9X RFC5	1.66e-03	95	85	3	29490077
Pubmed	Interaction network of human early embryonic transcription factors.	TNPO1 TBK1 SMARCD3 SPEN SLX4	1.73e-03	351	85	5	38297188
Pubmed	Affinity purification strategies for proteomic analysis of transcription factor complexes.	SMC3 SAP18 RFC5	1.76e-03	97	85	3	23937658
Pubmed	Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.	TNPO1 NOLC1 P4HB USP9X UGP2 IRF2BPL SSB RFC5 CNP SEPTIN2	1.84e-03	1367	85	10	32687490
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	RBM45 P4HB SAP18 TBK1 AHR CHD2 SSB TBC1D8B CNP DDX10	1.88e-03	1371	85	10	36244648
Coexpression	GSE7218_IGM_VS_IGG_SIGNAL_THGOUGH_ANTIGEN_BCELL_DN	PLA2G4C SCN4A INSRR SV2C AIDA CCR8 RGS16	1.38e-06	170	85	7	M6808
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ Genital tubercle M_emap-6706_top-relative-expression-ranked_1000	ORC5 ZNF560 ABCA5 SMC3 PTBP2 USP9X UGP2 PEX13 INSYN2B CPA3 CHD1 KAT6B TBC1D8B	2.06e-05	836	83	13	gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle M_1000
Disease	Ovarian cyst	GREB1 TERT	7.59e-05	5	82	2	HP_0000138
Disease	Uterine leiomyoma, estrogen-receptor negative breast cancer	TERT DDX10	3.38e-04	10	82	2	EFO_1000650, HP_0000131
Disease	Major Depressive Disorder	ADRA1A NTRK2 TERT ITIH1 CNP	5.92e-04	243	82	5	C1269683
Disease	Unipolar Depression	ADRA1A NTRK2 TERT ITIH1 CNP	7.89e-04	259	82	5	C0041696
Disease	cleft lip	ABCC8 CPA2 KAT6B ANKFN1 SEPTIN2	1.19e-03	284	82	5	EFO_0003959
Disease	serum albumin measurement	TNPO1 ABCA5 NYNRIN IRF2BPL TERT ITIH1 SEPTIN2	1.31e-03	592	82	7	EFO_0004535
Disease	Osteoarthritis of hip	GDF5 ITIH1	1.40e-03	20	82	2	C0029410
Disease	polycystic ovary syndrome (biomarker_via_orthology)	ADRA1A HSD17B7	1.55e-03	21	82	2	DOID:11612 (biomarker_via_orthology)
Disease	Prostatic Neoplasms	P4HB PPFIBP2 AHR CHD1 GREB1 SPEN TERT	1.64e-03	616	82	7	C0033578
Disease	Malignant neoplasm of prostate	P4HB PPFIBP2 AHR CHD1 GREB1 SPEN TERT	1.64e-03	616	82	7	C0376358

Protein segments in the cluster

Peptide	Gene	Start	Entry
FKKSKHVGIVEFFVT	ABCA5	321	Q8WWZ7
TIAKFHFFTLKRESK	ABCA5	846	Q8WWZ7
RTKNFIFRTKHKLDF	AHR	281	P35869
SSHKSFPKIFQTFRK	ERICH6	131	Q7L0X2
HRVKKAIDFKSRGFK	CSMD3	446	Q7Z407
GFFFKIKGLKHDTTS	BTBD16	401	Q32M84
AKTKTHFSVRLLKFS	ADRA1A	251	P35348
DFIKSHGKVKAFITL	CPA2	291	P48052
FHGSIIFFDKKALSF	AADACL4	376	Q5VUY2
EKLTKGAAIFFEFKH	AIDA	231	Q96BJ3
FVSKFTEFDARKLHK	CHD1	1481	O14646
AVSKLFFKLSAYGKH	ADAMTS6	81	Q9UKP5
HTKESKGIAFVKFAR	RBM45	61	Q8IUH3
VLKFTKGKSFRHEKT	NOLC1	661	Q14978
GSIFKAIAHFKRTTF	KAT6B	611	Q8WYB5
VHEKALFLVFGRTKK	GDF5	336	P43026
LFFHKGAKKSRFDLE	MCU	301	Q8NE86
SFISHGDLIKFFKTL	KIAA0825	86	Q8IV33
LHKAFKGSIFVVFDS	SSB	146	P05455
TKRFLFHYSKTQKLG	NMU	101	P48645
SFVGASFLKKFHFLK	GREB1	1881	Q4ZG55
SFLKKFHFLKGATLC	GREB1	1886	Q4ZG55
IKKSFSGKKGHVLFR	ITIH1	221	P19827
FKTNRKTRFIIHGFI	PNLIP	81	P16233
RFKKDHSLLGRVFAF	IRF2BPL	391	Q9H1B7
SKILKAIALKEGFHF	PGM2L1	391	Q6PCE3
TLLVHFFGKKGKAEL	MICU3	341	Q86XE3
KTAAESFKGKILFIF	P4HB	276	P07237
LGFSHFGNIRKKKFD	PPFIBP2	816	Q8ND30
GAFVSITHFGSKFKK	PLA2G4C	206	Q9UP65
ITHFGSKFKKGRLVR	PLA2G4C	211	Q9UP65
LRKLFDQHKTKFGIS	AWAT2	311	Q6E213
IKHTFAFELRDKGKF	CPA3	371	P15088
KRFFAFSVGRKTALH	C1QTNF6	141	Q9BXI9
FVSKFTEFDARKLHK	CHD2	1536	O14647
AFVGEKFKKHLSEIF	CCR8	301	P51685
HRGFKRVIQSKGIKF	CC2D1B	766	Q5T0F9
KGIKFEIFHKGSFFR	CC2D1B	776	Q5T0F9
SRKSHTFLPKIFFRK	CNP	6	P09543
IKALFFGLFSRKVIH	HSD17B7	101	P56937
FLKIKHSFALVSLGF	INSRR	381	P14616
CFFKSFKGKLHKDRS	FAM167A-AS1	6	Q96KT0
FKHIFFRSFVKSSGV	SPAM1	6	P38567
SFLRSHLKKKSIVFF	DDX10	306	Q13206
VKKRINTRFFLKHGS	PIWIL3	761	Q7Z3Z3
EFKRALKEFIFLHGK	NYNRIN	1721	Q9P2P1
GFGFASKTKKKHFVQ	PIP4K2C	21	Q8TBX8
FLFTTGFHTKKVVRG	USP9X	2051	Q93008
VKKGFRAAFRFQKEL	MRPL44	31	Q9H9J2
KAFKHVFGKTLICRS	SMC3	621	Q9UQE7
RFIGVKFKSVTFKDS	SV2C	501	Q496J9
KTFIVLNKGKAIFRF	SCN4A	91	P35499
FSKFGAVLKIITFTK	PTBP2	201	Q9UKA9
LSFASTRTIFKKGFK	RFC5	106	P40937
LGTCFGKFTKTHKFR	NIP7	66	Q9Y221
RFFLKHHGKIKKTNF	ORC5	326	O43913
FRKKFKFEGEIVVHT	PRAM1	576	Q96QH2
RKATKSKLFEFLVHG	SMARCD3	11	Q6STE5
LKIHFTKVFSAFALV	PEX13	171	Q92968
RKKGTHFNFAIVFTD	SAP18	81	O00422
FIFVVRKKSHGKDTK	SLCO1B7	596	G3V0H7
ASFFQRVKKHGIKEV	SLX4	56	Q8IY92
AFITKTIKFVKFLDH	ABCC8	146	Q09428
TIKFVKFLDHAIGFS	ABCC8	151	Q09428
LFHSSNKFVKTLKRG	ANKFN1	426	Q8N957
ARKLTSFFKKIGVHF	CIAO3	136	Q9H6Q4
RFKFLSKLLFVHGHF	ATP11B	856	Q9Y2G3
FGEKSKALKVFNFVR	NLRP9	311	Q7RTR0
SGLKFVAHKAFLKNS	NTRK2	101	Q16620
VRSTLKKVFGFDSFK	RECQL5	16	O94762
KFASKELFKGFARHL	RECQL5	931	O94762
KAFSFKSLLISHKRI	ZFP1	191	Q6P2D0
GKAFKRFSALRKHKI	ZNF99	431	A8MXY4
TKKDLDGFRKLFHRF	UGP2	51	Q16851
TKHFVSKKFGKIFSD	ZNF596	136	Q8TC21
FHEFKKFGKVTSVQI	SPEN	356	Q96T58
ISIKGKTAFRFHEVK	TBC1D8B	361	Q0IIM8
AKEFKTRLGIFLHKS	RGS16	16	O15492
RFLFTTGFHTKKIVR	USP9Y	2051	O00507
KFLQFFKHSSPKIRS	TNPO1	186	Q92973
QVHRKSVKKGFEFTL	SEPTIN2	26	Q15019
ELIGFHRKSAFFKRV	TRAPPC9	396	Q96Q05
KAHKNILVAGSRFFK	ZBTB10	376	Q96DT7
LIRFGKKKNTHSLFV	SOHLH2	86	Q9NX45
ADFRKFFAKAKHIVI	SIRT5	41	Q9NXA8
KAFRKPSIFTLHKKT	ZNF559	126	Q9BR84
RFLRNTKKFISLGKH	TERT	486	O14746
GRHKKTGDLFAIKVF	TBK1	26	Q9UHD2
IRKVSVFSKHGKSFR	ZNF560	261	Q96MR9
GKAFKCFSILTTHKR	ZNF737	431	O75373
HFPVFKRKRLTASKS	INSYN2B	106	A6NMK8