Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionpeptidyltransferase activity

GGT2P GGT1 GGT3P

2.94e-076503GO:0000048
GeneOntologyMolecularFunctionleukotriene-C(4) hydrolase

GGT2P GGT1 GGT3P

2.94e-076503GO:0002951
GeneOntologyMolecularFunctionleukotriene C4 gamma-glutamyl transferase activity

GGT2P GGT1 GGT3P

8.20e-078503GO:0103068
GeneOntologyMolecularFunctionglutathione hydrolase activity

GGT2P GGT1 GGT3P

1.23e-069503GO:0036374
GeneOntologyMolecularFunctionomega peptidase activity

GGT2P GGT1 GGT3P

8.09e-0616503GO:0008242
GeneOntologyMolecularFunctionthreonine-type peptidase activity

GGT2P GGT1 GGT3P

1.63e-0520503GO:0070003
GeneOntologyBiologicalProcesscysteine biosynthetic process

GGT2P GGT1 GGT3P

7.44e-078503GO:0019344
GeneOntologyBiologicalProcesspeptide biosynthetic process

FURIN GGT2P GGT1 GGT3P

1.34e-0634504GO:0043043
GeneOntologyBiologicalProcesspeptide modification

GGT2P GGT1 GGT3P

1.59e-0610503GO:0031179
GeneOntologyBiologicalProcessleukotriene D4 biosynthetic process

GGT2P GGT1 GGT3P

1.59e-0610503GO:1901750
GeneOntologyBiologicalProcessglutathione catabolic process

GGT2P GGT1 GGT3P

2.18e-0611503GO:0006751
GeneOntologyBiologicalProcessleukotriene D4 metabolic process

GGT2P GGT1 GGT3P

2.90e-0612503GO:1901748
GeneOntologyBiologicalProcesscysteine metabolic process

GGT2P GGT1 GGT3P

7.34e-0616503GO:0006534
GeneOntologyBiologicalProcessglutathione biosynthetic process

GGT2P GGT1 GGT3P

1.48e-0520503GO:0006750
GeneOntologyBiologicalProcesssulfur amino acid biosynthetic process

GGT2P GGT1 GGT3P

1.73e-0521503GO:0000097
GeneOntologyBiologicalProcessleukotriene biosynthetic process

GGT2P GGT1 GGT3P

2.00e-0522503GO:0019370
GeneOntologyBiologicalProcessnonribosomal peptide biosynthetic process

GGT2P GGT1 GGT3P

2.00e-0522503GO:0019184
GeneOntologyBiologicalProcessserine family amino acid biosynthetic process

GGT2P GGT1 GGT3P

2.97e-0525503GO:0009070
GeneOntologyBiologicalProcesspeptide metabolic process

FURIN GGT2P GGT1 GGT3P

5.11e-0584504GO:0006518
GeneOntologyBiologicalProcessspermatogenesis

SPATA31A1 SPATA31A3 GGN SPATA31A7 SHBG SPATA31A5 GGT2P GGT1 GGT3P

6.55e-05744509GO:0007283
GeneOntologyBiologicalProcessmale gamete generation

SPATA31A1 SPATA31A3 GGN SPATA31A7 SHBG SPATA31A5 GGT2P GGT1 GGT3P

7.86e-05762509GO:0048232
GeneOntologyBiologicalProcessmodified amino acid catabolic process

GGT2P GGT1 GGT3P

9.83e-0537503GO:0042219
GeneOntologyBiologicalProcesssulfur amino acid metabolic process

GGT2P GGT1 GGT3P

1.24e-0440503GO:0000096
GeneOntologyBiologicalProcessleukotriene metabolic process

GGT2P GGT1 GGT3P

1.34e-0441503GO:0006691
GeneOntologyBiologicalProcessserine family amino acid metabolic process

GGT2P GGT1 GGT3P

1.54e-0443503GO:0009069
GeneOntologyBiologicalProcessfatty acid derivative biosynthetic process

GGT2P GGT1 GGT3P

2.72e-0452503GO:1901570
GeneOntologyBiologicalProcessmodified amino acid biosynthetic process

GGT2P GGT1 GGT3P

2.72e-0452503GO:0042398
GeneOntologyBiologicalProcesssulfur compound catabolic process

GGT2P GGT1 GGT3P

2.88e-0453503GO:0044273
GeneOntologyBiologicalProcessglutathione metabolic process

GGT2P GGT1 GGT3P

4.80e-0463503GO:0006749
GeneOntologyBiologicalProcessgamete generation

SPATA31A1 SPATA31A3 GGN SPATA31A7 SHBG SPATA31A5 GGT2P GGT1 GGT3P

5.21e-04982509GO:0007276
GeneOntologyBiologicalProcesszymogen activation

FURIN GGT2P GGT1

5.27e-0465503GO:0031638
GeneOntologyBiologicalProcessicosanoid biosynthetic process

GGT2P GGT1 GGT3P

5.76e-0467503GO:0046456
GeneOntologyBiologicalProcessproteinogenic amino acid biosynthetic process

GGT2P GGT1 GGT3P

6.27e-0469503GO:0170038
GeneOntologyBiologicalProcessL-amino acid biosynthetic process

GGT2P GGT1 GGT3P

6.54e-0470503GO:0170034
GeneOntologyBiologicalProcessalpha-amino acid biosynthetic process

GGT2P GGT1 GGT3P

8.64e-0477503GO:1901607
GeneOntologyBiologicalProcesssulfur compound biosynthetic process

CHST14 GGT2P GGT1 GGT3P

9.06e-04178504GO:0044272
GeneOntologyBiologicalProcesscell-cell adhesion mediated by integrin

PIEZO1 ITGA5

9.59e-0419502GO:0033631
GeneOntologyBiologicalProcessfatty acid derivative metabolic process

GGT2P GGT1 GGT3P

1.04e-0382503GO:1901568
GeneOntologyBiologicalProcesssexual reproduction

SPATA31A1 SPATA31A3 GGN SPATA31A7 SHBG SPATA31A5 SYDE1 GGT2P GGT1 GGT3P

1.04e-0313125010GO:0019953
GeneOntologyBiologicalProcessregulation of hydrolase activity

COL7A1 MYO9B AIFM1 FURIN TBC1D2 ARHGEF26 BBC3 SYDE1

1.15e-03878508GO:0051336
GeneOntologyBiologicalProcessamino acid biosynthetic process

GGT2P GGT1 GGT3P

1.19e-0386503GO:0008652
GeneOntologyBiologicalProcesspositive regulation of hydrolase activity

MYO9B AIFM1 TBC1D2 ARHGEF26 BBC3 SYDE1

1.25e-03499506GO:0051345
GeneOntologyCellularComponentRNA-directed RNA polymerase complex

ZNFX1 TERT

1.68e-053502GO:0031379
MousePhenoabnormal circulating glutathione level

GGT2P GGT1 GGT3P

1.43e-075353MP:0030652
MousePhenoincreased circulating glutathione level

GGT2P GGT1 GGT3P

1.43e-075353MP:0030653
MousePhenoincreased glutathione level

GGT2P GGT1 GGT3P

1.43e-075353MP:0012606
MousePhenoglutathionuria

GGT2P GGT1 GGT3P

1.43e-075353MP:0013730
MousePhenodecreased circulating cysteine level

GGT2P GGT1 GGT3P

5.00e-077353MP:0030626
MousePhenoepididymis hypoplasia

GGT2P GGT1 GGT3P

7.98e-078353MP:0004932
MousePhenodecreased cysteine level

GGT2P GGT1 GGT3P

7.98e-078353MP:0030623
MousePhenonervous

GGT2P GGT1 GGT3P

1.20e-069353MP:0008912
MousePhenofailure of copulatory plug deposition

GGT2P GGT1 GGT3P

1.70e-0610353MP:0030983
MousePhenoseminal vesicle hypoplasia

GGT2P GGT1 GGT3P

1.70e-0610353MP:0005148
MousePhenoovary hypoplasia

GGT2P GGT1 GGT3P

1.70e-0610353MP:0005158
MousePhenoabnormal circulating cysteine level

GGT2P GGT1 GGT3P

2.34e-0611353MP:0030624
MousePhenoabsent tertiary ovarian follicles

GGT2P GGT1 GGT3P

2.34e-0611353MP:0011130
MousePhenoabnormal cysteine level

GGT2P GGT1 GGT3P

4.04e-0613353MP:0030621
MousePhenodecreased glutathione level

GGT2P GGT1 GGT3P

4.04e-0613353MP:0012604
MousePhenoabnormal glutathione level

GGT2P GGT1 GGT3P

4.04e-0613353MP:0012603
MousePhenopriapism

GGT2P GGT1 GGT3P

5.14e-0614353MP:0003415
MousePhenodecreased thyroxine level

TRH GGT2P GGT1 GGT3P

7.57e-0651354MP:0005471
MousePhenoabnormal copulatory plug deposition

GGT2P GGT1 GGT3P

7.87e-0616353MP:0030982
MousePhenodecreased spleen red pulp amount

GGT2P GGT1 GGT3P

7.87e-0616353MP:0008477
MousePhenofailure of superovulation

GGT2P GGT1 GGT3P

1.14e-0518353MP:0031422
MousePhenoabnormal penile erection

GGT2P GGT1 GGT3P

1.14e-0518353MP:0001379
MousePhenooocyte degeneration

GGT2P GGT1 GGT3P

1.14e-0518353MP:0009093
MousePhenoabnormal copulation physiology

GGT2P GGT1 GGT3P

1.36e-0519353MP:0031627
MousePhenoincreased circulating growth hormone level

GGT2P GGT1 GGT3P

1.36e-0519353MP:0005123
MousePhenoabnormal thyroxine level

TRH GGT2P GGT1 GGT3P

2.13e-0566354MP:0005469
MousePhenosmall vertebrae

GGT2P GGT1 GGT3P

2.14e-0522353MP:0004610
MousePhenoincreased growth hormone level

GGT2P GGT1 GGT3P

2.46e-0523353MP:0005137
MousePhenouterus hypoplasia

GGT2P GGT1 GGT3P

2.46e-0523353MP:0001121
MousePhenoabnormal copulation behavior

GGT2P GGT1 GGT3P

2.81e-0524353MP:0009697
MousePhenoabnormal thyroid hormone level

TRH GGT2P GGT1 GGT3P

3.35e-0574354MP:0005468
MousePhenonuclear cataract

GGT2P GGT1 GGT3P

3.59e-0526353MP:0010254
MousePhenoaminoaciduria

GGT2P GGT1 GGT3P

5.02e-0529353MP:0003311
MousePhenodecreased circulating pituitary hormone level

TRH GGT2P GGT1 GGT3P

6.91e-0589354MP:0005118
MousePhenoanovulation

GGT2P GGT1 GGT3P

7.45e-0533353MP:0008869
MousePhenodecreased circulating follicle stimulating hormone level

GGT2P GGT1 GGT3P

8.16e-0534353MP:0002790
MousePhenodecreased amino acid level

TRH GGT2P GGT1 GGT3P

9.67e-0597354MP:0014528
MousePhenodecreased circulating estradiol level

GGT2P GGT1 GGT3P

1.14e-0438353MP:0005181
MousePhenodecreased tertiary ovarian follicle number

GGT2P GGT1 GGT3P

1.24e-0439353MP:0011129
MousePhenodecreased circulating estrogen level

GGT2P GGT1 GGT3P

1.44e-0441353MP:0003371
MousePhenoabnormal limb morphology

COL7A1 CHST14 PIEZO1 FURIN CPLANE1 FAM20A GGT2P GGT1 GGT3P DYRK2

1.49e-0410283510MP:0002109
MousePhenoinduced hyperactivity

GGT2P GGT1 GGT3P

1.54e-0442353MP:0008911
MousePhenodecreased pituitary hormone level

TRH GGT2P GGT1 GGT3P

1.75e-04113354MP:0003972
MousePhenodecreased follicle stimulating hormone level

GGT2P GGT1 GGT3P

1.77e-0444353MP:0005130
MousePhenodecreased long bone epiphyseal plate size

GGT2P GGT1 GGT3P

1.77e-0444353MP:0006396
MousePhenoabsent estrous cycle

GGT2P GGT1 GGT3P

1.77e-0444353MP:0009009
MousePhenoabnormal tertiary ovarian follicle number

GGT2P GGT1 GGT3P

2.16e-0447353MP:0011127
MousePhenoabnormal amino acid derivative level

TRH GGT2P GGT1 GGT3P

2.57e-04125354MP:0021145
MousePhenoincreased pituitary hormone level

TRH GGT2P GGT1 GGT3P

2.82e-04128354MP:0003973
MousePhenoabnormal circulating estradiol level

GGT2P GGT1 GGT3P

2.92e-0452353MP:0005183
MousePhenoaciduria

GGT2P GGT1 GGT3P

3.45e-0455353MP:0010028
MousePhenoabnormal vertebrae morphology

R3HDM1 CPLANE1 TERT GGT2P GGT1 GGT3P DYRK2

3.46e-04546357MP:0000137
MousePhenoabnormal circulating estrogen level

GGT2P GGT1 GGT3P

3.83e-0457353MP:0003369
MousePhenoabnormal tertiary ovarian follicle morphology

GGT2P GGT1 GGT3P

3.83e-0457353MP:0009363
MousePhenodisproportionate dwarf

GGT2P GGT1 GGT3P

3.83e-0457353MP:0002427
MousePhenoabnormal growth hormone level

GGT2P GGT1 GGT3P

3.83e-0457353MP:0003968
MousePhenoabnormal urine amino acid level

GGT2P GGT1 GGT3P

4.25e-0459353MP:0011468
MousePhenoimmotile sperm

GGT2P GGT1 GGT3P

4.25e-0459353MP:0020869
MousePhenodecreased circulating gonadotropin level

GGT2P GGT1 GGT3P

4.46e-0460353MP:0003363
MousePhenodecreased circulating testosterone level

GGT2P GGT1 GGT3P

4.46e-0460353MP:0002780
MousePhenodecreased circulating insulin-like growth factor I level

GGT2P GGT1 GGT3P

4.68e-0461353MP:0004701
MousePhenoimpaired ovarian folliculogenesis

GGT2P GGT1 GGT3P

4.68e-0461353MP:0001129
MousePhenodiluted coat color

GGT2P GGT1 GGT3P

5.40e-0464353MP:0000371
MousePhenoabnormal vertebral column morphology

CNTNAP1 R3HDM1 CPLANE1 TERT GGT2P GGT1 GGT3P DYRK2

5.89e-04787358MP:0004703
MousePhenoabnormal superovulation

GGT2P GGT1 GGT3P

5.91e-0466353MP:0009648
MousePhenoabsent corpus luteum

GGT2P GGT1 GGT3P

5.91e-0466353MP:0001134
MousePhenoabnormal long bone epiphyseal plate proliferative zone

GGT2P GGT1 GGT3P

6.45e-0468353MP:0003662
MousePhenosmall epididymis

GGT2P GGT1 GGT3P

7.02e-0470353MP:0004930
MousePhenolimbs/digits/tail phenotype

COL7A1 CHST14 PIEZO1 FURIN CPLANE1 FAM20A GGT2P GGT1 GGT3P DYRK2

7.60e-0412583510MP:0005371
MousePhenoabnormal circulating insulin-like growth factor I level

GGT2P GGT1 GGT3P

7.62e-0472353MP:0004700
MousePhenoabnormal insulin-like growth factor I level

GGT2P GGT1 GGT3P

8.58e-0475353MP:0008831
MousePhenoabnormal circulating pituitary hormone level

TRH GGT2P GGT1 GGT3P

8.60e-04172354MP:0005116
MousePhenoshort rostral-caudal axis

FURIN ITGA5

9.09e-0418352MP:0012173
MousePhenoincreased osteoclast cell number

GGT2P GGT1 GGT3P

9.26e-0477353MP:0004984
MousePhenohindlimb paralysis

GGT2P GGT1 GGT3P

9.98e-0479353MP:0000755
MousePhenolimb paralysis

GGT2P GGT1 GGT3P

1.15e-0383353MP:0013147
MousePhenodecreased circulating amino acid level

TRH GGT2P GGT1 GGT3P

1.17e-03187354MP:0014531
MousePhenoabnormal circulating testosterone level

GGT2P GGT1 GGT3P

1.19e-0384353MP:0005180
MousePhenoabnormal circulating androgen level

GGT2P GGT1 GGT3P

1.19e-0384353MP:0009819
MousePhenoabnormal long bone morphology

COL7A1 CHST14 CPLANE1 FAM20A GGT2P GGT1 GGT3P

1.23e-03676357MP:0003723
MousePhenoabnormal appendicular skeleton morphology

COL7A1 CHST14 CPLANE1 FAM20A GGT2P GGT1 GGT3P DYRK2

1.38e-03896358MP:0009250
MousePhenoabnormal follicle stimulating hormone level

GGT2P GGT1 GGT3P

1.41e-0389353MP:0003967
MousePhenoabnormal testosterone level

GGT2P GGT1 GGT3P

1.55e-0392353MP:0011385
MousePhenosmall uterus

GGT2P GGT1 GGT3P

1.55e-0392353MP:0002637
MousePhenoabnormal sexual interaction

GGT2P GGT1 GGT3P

1.65e-0394353MP:0002566
MousePhenoabnormal ovulation

GGT2P GGT1 GGT3P

1.80e-0397353MP:0001928
MousePhenoabnormal reproductive system development

GGT2P GGT1 GGT3P

1.91e-0399353MP:0003936
MousePhenoabnormal pituitary hormone level

TRH GGT2P GGT1 GGT3P

1.93e-03214354MP:0003965
MousePhenodecreased bone mass

GGT2P GGT1 GGT3P

1.97e-03100353MP:0004016
MousePhenodecreased somite size

AIFM1 FURIN

2.21e-0328352MP:0011732
MousePhenoabnormal tibia morphology

CHST14 FAM20A GGT2P GGT1 GGT3P

2.26e-03375355MP:0000558
MousePhenoabnormal axial skeleton morphology

CHST14 CNTNAP1 R3HDM1 CPLANE1 FAM20A TERT GGT2P GGT1 GGT3P DYRK2

2.36e-0314583510MP:0002114
MousePhenosmall seminiferous tubules

GGT2P GGT1 GGT3P

2.39e-03107353MP:0001153
MousePhenoabnormal hindlimb zeugopod morphology

CHST14 FAM20A GGT2P GGT1 GGT3P

2.43e-03381355MP:0003857
MousePhenokyphosis

CNTNAP1 GGT2P GGT1 GGT3P

2.47e-03229354MP:0000160
MousePhenoincreased circulating pituitary hormone level

GGT2P GGT1 GGT3P

2.58e-03110353MP:0005117
MousePhenoabnormal spleen red pulp morphology

GGT2P GGT1 GGT3P

2.58e-03110353MP:0002356
MousePhenoabnormal seminiferous tubule size

GGT2P GGT1 GGT3P

2.65e-03111353MP:0006307
MousePhenoabnormal circulating gonadotropin level

GGT2P GGT1 GGT3P

2.72e-03112353MP:0003361
MousePhenoabnormal long bone hypertrophic chondrocyte zone

GGT2P GGT1 GGT3P

2.79e-03113353MP:0000165
DomainDUF4599

SPATA31A3 SPATA31A7 SPATA31A5

3.23e-0612473PF15371
DomainDUF4599

SPATA31A3 SPATA31A7 SPATA31A5

3.23e-0612473IPR027970
DomainGGT_peptidase

GGT1 GGT3P

1.29e-047472IPR000101
DomainG_glu_transpept

GGT1 GGT3P

1.29e-047472PF01019
DomainG_GLU_TRANSPEPTIDASE

GGT1 GGT3P

1.29e-047472PS00462
DomainLAM_G_DOMAIN

CNTNAP1 SHBG

4.11e-0338472PS50025
DomainLamG

CNTNAP1 SHBG

5.48e-0344472SM00282
DomainLaminin_G

CNTNAP1 SHBG

9.37e-0358472IPR001791
DomainRhoGAP

MYO9B SYDE1

1.06e-0262472SM00324
DomainRhoGAP

MYO9B SYDE1

1.10e-0263472PF00620
DomainRHOGAP

MYO9B SYDE1

1.13e-0264472PS50238
DomainRhoGAP_dom

MYO9B SYDE1

1.13e-0264472IPR000198
Domain-

MYO9B SYDE1

1.13e-02644721.10.555.10
DomainKinase-like_dom

WEE1 DSTYK ACAD10 MAP3K21 DYRK2

1.14e-02542475IPR011009
DomainSer/Thr_kinase_AS

WEE1 DSTYK MAP3K21 DYRK2

1.23e-02357474IPR008271
DomainS_TKc

WEE1 DSTYK MAP3K21 DYRK2

1.25e-02359474SM00220
DomainPROTEIN_KINASE_ST

WEE1 DSTYK MAP3K21 DYRK2

1.29e-02362474PS00108
PathwayREACTOME_GLUTATHIONE_SYNTHESIS_AND_RECYCLING

GGT2P GGT1 GGT3P

8.37e-0616363MM14680
PathwayWP_EICOSANOID_SYNTHESIS

GGT2P GGT1 GGT3P

2.28e-0522363MM15961
PathwayWP_OXYLIPINS_PATHWAYS

GGT2P GGT1 GGT3P

2.98e-0524363MM17249
PathwayREACTOME_SYNTHESIS_OF_LEUKOTRIENES_LT_AND_EOXINS_EX

GGT2P GGT1 GGT3P

3.38e-0525363MM14858
PathwayREACTOME_AFLATOXIN_ACTIVATION_AND_DETOXIFICATION

GGT2P GGT1 GGT3P

3.82e-0526363MM15190
PathwayWP_GLUTATHIONE_METABOLISM

GGT2P GGT1 GGT3P

4.29e-0527363MM15908
PathwayWP_EICOSANOID_METABOLISM_VIA_LIPOXYGENASES_LOX

GGT2P GGT1 GGT3P

7.92e-0533363MM15963
PathwayWP_GLUTATHIONE_AND_ONECARBON_METABOLISM

GGT2P GGT1 GGT3P

9.46e-0535363MM15815
PathwayREACTOME_GLUTATHIONE_CONJUGATION

GGT2P GGT1 GGT3P

1.21e-0438363MM14600
PathwayREACTOME_PARACETAMOL_ADME

GGT2P GGT1 GGT3P

1.31e-0439363MM15695
PathwayREACTOME_INDUCTION_OF_CELL_CELL_FUSION

ANO9 FURIN

4.86e-0413362M46426
PathwayREACTOME_ARACHIDONIC_ACID_METABOLISM

GGT2P GGT1 GGT3P

4.97e-0461363MM14861
PathwayREACTOME_FATTY_ACID_METABOLISM

ACAD10 GGT2P GGT1 GGT3P

8.90e-04170364MM15573
Pubmed

The testis-specific VAD1.3/AEP1 interacts with β-actin and syntaxin 1 and directs peri-nuclear/Golgi expression with bipartite nucleus localization (BNL) sequence.

SPATA31A1 SPATA31A3 SPATA31A7 SPATA31A5

5.66e-11650420850414
Pubmed

Targeted disruption of the spermatid-specific gene Spata31 causes male infertility.

SPATA31A1 SPATA31A3 SPATA31A7 SPATA31A5

5.66e-11650425930072
Pubmed

Different gamma-glutamyl transpeptidase mRNAs are expressed in human liver and kidney.

GGT2P GGT1 GGT3P

2.80e-0935032573352
Pubmed

Lung lining fluid glutathione attenuates IL-13-induced asthma.

GGT2P GGT1 GGT3P

2.79e-08550318063838
Pubmed

Gamma-glutamyltranspeptidase knockout mice as a model for understanding the consequences of diminished glutathione on T cell-dependent immune responses.

GGT2P GGT1 GGT3P

2.79e-08550310940879
Pubmed

Cataract development in gamma-glutamyl transpeptidase-deficient mice.

GGT2P GGT1 GGT3P

2.79e-08550311095909
Pubmed

Expression of gamma-glutamyl transpeptidase in midgestation mouse yolk sac and mouse visceral yolk sac carcinoma cells.

GGT2P GGT1 GGT3P

2.79e-0855037641802
Pubmed

Phenotypic characterization of Ggt1(dwg/dwg) mice,a mouse model for hereditary γ-glutamyltransferase deficiency.

GGT2P GGT1 GGT3P

2.79e-08550323615310
Pubmed

The mouse skin carcinogenesis model.

GGT2P GGT1 GGT3P

2.79e-0855039627710
Pubmed

Gamma-glutamyl transpeptidase and its role in melanogenesis: redox reactions and regulation of tyrosinase.

GGT2P GGT1 GGT3P

2.79e-08550312453183
Pubmed

gamma-glutamyltranspeptidase-deficient knockout mice as a model to study the relationship between glutathione status, mitochondrial function, and cellular function.

GGT2P GGT1 GGT3P

2.79e-08550311003618
Pubmed

Gamma-glutamyl transpeptidase gene organization and expression: a comparative analysis in rat, mouse, pig and human species.

GGT2P GGT1 GGT3P

2.79e-08550310392451
Pubmed

Immunocytochemical localization of gamma-glutamyltranspeptidase during fetal development of mouse kidney.

GGT2P GGT1 GGT3P

2.79e-0855032891746
Pubmed

Hyperoxia-induced lung injury in gamma-glutamyl transferase deficiency is associated with alterations in nitrosative and nitrative stress.

GGT2P GGT1 GGT3P

2.79e-08550319850887
Pubmed

Reversible skeletal abnormalities in gamma-glutamyl transpeptidase-deficient mice.

GGT2P GGT1 GGT3P

2.79e-08550312810527
Pubmed

Growth retardation and cysteine deficiency in gamma-glutamyl transpeptidase-deficient mice.

GGT2P GGT1 GGT3P

2.79e-0855038755578
Pubmed

Reproductive defects in gamma-glutamyl transpeptidase-deficient mice.

GGT2P GGT1 GGT3P

2.79e-08550311089562
Pubmed

Liver-Specific Overexpression of Gamma-Glutamyltransferase Ameliorates Insulin Sensitivity of Male C57BL/6 Mice.

GGT2P GGT1 GGT3P

2.79e-08550328660214
Pubmed

Bleomycin-induced pulmonary fibrosis is attenuated in gamma-glutamyl transpeptidase-deficient mice.

GGT2P GGT1 GGT3P

2.79e-08550312468440
Pubmed

N-acetyl-cysteine prevents age-related hearing loss and the progressive loss of inner hair cells in γ-glutamyl transferase 1 deficient mice.

GGT2P GGT1 GGT3P

2.79e-08550326977590
Pubmed

Gamma-glutamyl transferase deficiency results in lung oxidant stress in normoxia.

GGT2P GGT1 GGT3P

2.79e-08550312225953
Pubmed

Identification of a sixth promoter that directs the transcription of gamma-glutamyl transpeptidase type III RNA in mouse.

GGT2P GGT1 GGT3P

2.79e-0855037775425
Pubmed

Cloning of cDNA and genomic structure of the mouse gamma-glutamyl transpeptidase-encoding gene.

GGT2P GGT1 GGT3P

2.79e-0855038566783
Pubmed

Therapeutic Effect of GGsTop, Selective Gamma-glutamyl Transpeptidase Inhibitor, on a Mouse Model of 5-Fluorouracil-induced Oral Mucositis.

GGT2P GGT1 GGT3P

2.79e-08550330591459
Pubmed

Mice with genetic gamma-glutamyl transpeptidase deficiency exhibit glutathionuria, severe growth failure, reduced life spans, and infertility.

GGT2P GGT1 GGT3P

2.79e-0855039139708
Pubmed

Analysis of site-specific glycosylation of renal and hepatic γ-glutamyl transpeptidase from normal human tissue.

GGT2P GGT1 GGT3P

2.79e-08550320622017
Pubmed

Accelerated methylmercury elimination in gamma-glutamyl transpeptidase-deficient mice.

GGT2P GGT1 GGT3P

2.79e-0855039546365
Pubmed

In vivo reversal of glutathione deficiency and susceptibility to in vivo dexamethasone-induced apoptosis by N-acetylcysteine and L-2-oxothiazolidine-4-carboxylic acid, but not ascorbic acid, in thymocytes from gamma-glutamyltranspeptidase-deficient knockout mice.

GGT2P GGT1 GGT3P

2.79e-08550311795900
Pubmed

gamma-Glutamyl transpeptidase. What does the organization and expression of a multipromoter gene tell us about its functions?

GGT2P GGT1 GGT3P

2.79e-0855037485380
Pubmed

Accumulation of DNA damage in the organs of mice deficient in gamma-glutamyltranspeptidase.

GGT2P GGT1 GGT3P

2.79e-08550310751614
Pubmed

Type VI RNA is the major gamma-glutamyl transpeptidase RNA in the mouse small intestine.

GGT2P GGT1 GGT3P

2.79e-0855037523374
Pubmed

Cardio-reno-hepatic interactions in acute heart failure: the role of γ-glutamyl transferase.

GGT2P GGT1 GGT3P

2.79e-08550324698228
Pubmed

Inhibiting lung lining fluid glutathione metabolism with GGsTop as a novel treatment for asthma.

GGT2P GGT1 GGT3P

2.79e-08550325132819
Pubmed

Characterization of the dwg mutations: dwg and dwg(Bayer) are new mutant alleles of the Ggt1 gene.

GGT2P GGT1 GGT3P

2.79e-08550319760322
Pubmed

gamma-Glutamyl transferase (GGT) deficiency in the GGTenu1 mouse results from a single point mutation that leads to a stop codon in the first coding exon of GGT mRNA.

GGT2P GGT1 GGT3P

2.79e-08550310474818
Pubmed

Majority of cerebrospinal fluid-contacting neurons in the spinal cord of C57Bl/6N mice is present in ectopic position unlike in other studied experimental mice strains and mammalian species.

SPATA31A1 SPATA31A3 SPATA31A7 SPATA31A5

3.93e-082450432212159
Pubmed

Gamma-glutamyltranspeptidase stimulates receptor activator of nuclear factor-kappaB ligand expression independent of its enzymatic activity and serves as a pathological bone-resorbing factor.

GGT2P GGT1 GGT3P

5.57e-08650314634009
Pubmed

Overexpression of gamma-glutamyltransferase in transgenic mice accelerates bone resorption and causes osteoporosis.

GGT2P GGT1 GGT3P

5.57e-08650317363454
Pubmed

Six mRNAs with different 5' ends are encoded by a single gamma-glutamyltransferase gene in mouse.

GGT2P GGT1 GGT3P

5.57e-0865038101000
Pubmed

Four distinct membrane-bound dipeptidase RNAs are differentially expressed and show discordant regulation with gamma-glutamyl transpeptidase.

GGT2P GGT1 GGT3P

5.57e-0865038663190
Pubmed

Mapping of human gamma-glutamyl transpeptidase genes on chromosome 22 and other human autosomes.

GGT2P GGT1 GGT3P

5.57e-0865038104871
Pubmed

Disruption of gamma-glutamyl leukotrienase results in disruption of leukotriene D(4) synthesis in vivo and attenuation of the acute inflammatory response.

GGT2P GGT1 GGT3P

5.57e-08650311463821
Pubmed

Effect of atorvastatin on the expression of gamma-glutamyl transferase in aortic atherosclerotic plaques of apolipoprotein E-knockout mice.

GGT2P GGT1 GGT3P

5.57e-08650325326709
Pubmed

Gamma-glutamyl leukotrienase, a novel endothelial membrane protein, is specifically responsible for leukotriene D(4) formation in vivo.

GGT2P GGT1 GGT3P

5.57e-08650312163373
Pubmed

Ablation of Mrds1/Ofcc1 induces hyper-γ-glutamyl transpeptidasemia without abnormal head development and schizophrenia-relevant behaviors in mice.

GGT2P GGT1 GGT3P

5.57e-08650322242126
Pubmed

γ-Glutamyltranspeptidase is an endogenous activator of Toll-like receptor 4-mediated osteoclastogenesis.

GGT2P GGT1 GGT3P

9.75e-08750327775020
Pubmed

Transcriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation.

GGT2P GGT1 GGT3P

9.75e-08750332284594
Pubmed

Defective epidermal growth factor gene expression in mice with polycystic kidney disease.

GGT2P GGT1 GGT3P

9.75e-0875031968405
Pubmed

m6A eraser FTO modulates autophagy by targeting SQSTM1/P62 in the prevention of canagliflozin against renal fibrosis.

GGT2P GGT1 GGT3P

9.75e-08750336685533
Pubmed

Renalase regulates renal dopamine and phosphate metabolism.

GGT2P GGT1 GGT3P

3.33e-071050323863468
Pubmed

The human gamma-glutamyltransferase gene family.

GGT2P GGT1 GGT3P

1.01e-061450318357469
Pubmed

Proprotein convertase furin interacts with and cleaves pro-ADAMTS4 (Aggrecanase-1) in the trans-Golgi network.

ADAMTS4 FURIN

2.03e-06250214744861
Pubmed

Gamma glutamyl transferase activity is independently associated with oxidative stress rather than SYNTAX score.

GGT2P GGT1

2.03e-06250225180444
Pubmed

Combination of DYRK2 and TERT Expression Is a Powerful Predictive Marker for Early-stage Breast Cancer Recurrence.

TERT DYRK2

2.03e-06250235347031
Pubmed

Association between serum γ-glutamyltranspeptidase and atherosclerosis: a population-based cross-sectional study.

GGT2P GGT1

2.03e-06250225280803
Pubmed

Clinical application value of hepatitis B virus basal core promoter 1762/1764 and GGTII and GGT in patients with HBV-DNA-positive primary liver cancer.

GGT2P GGT1

2.03e-06250237904480
Pubmed

Human GGT2 does not autocleave into a functional enzyme: A cautionary tale for interpretation of microarray data on redox signaling.

GGT2P GGT1

2.03e-06250223682772
Pubmed

Gene dosage in the developing and adult brain in a mouse model of 22q11 deletion syndrome.

GGT2P GGT1 GGT3P

2.25e-061850317097888
Pubmed

Acute contact with profibrotic macrophages mechanically activates fibroblasts via αvβ3 integrin-mediated engagement of Piezo1.

PIEZO1 ITGA5

6.07e-06350239441936
Pubmed

Hepatoblast-like cells enriched from mouse embryonic stem cells in medium without glucose, pyruvate, arginine, and tyrosine.

GGT2P GGT1 GGT3P

7.98e-062750318478268
Pubmed

Cell-surface proteomics identifies lineage-specific markers of embryo-derived stem cells.

GGT2P GGT1 GGT3P

9.95e-062950322424930
Pubmed

Dichotomy between the transcriptomic landscape of naturally versus accelerated aged murine hearts.

AIFM1 TERT

1.21e-05450232424227
Pubmed

Cloning and nucleotide sequence of human gamma-glutamyl transpeptidase.

GGT1 GGT3P

2.02e-0555022904146
Pubmed

Expression of multiple gamma-glutamyltransferase genes in man.

GGT1 GGT3P

2.02e-0555027906515
Pubmed

Genomic characterization of the lysophosphatidic acid receptor gene, lp(A2)/Edg4, and identification of a frameshift mutation in a previously characterized cDNA.

NPY1R MYO9B

2.02e-05550210729222
Pubmed

Direct reprogramming of fibroblasts into renal tubular epithelial cells by defined transcription factors.

GGT2P GGT1 GGT3P

2.28e-053850327820600
Pubmed

Dyrk2-associated EDD-DDB1-VprBP E3 ligase inhibits telomerase by TERT degradation.

TERT DYRK2

3.03e-05650223362280
Pubmed

Mouse models of ocular diseases.

GGT2P GGT1 GGT3P

3.55e-054450316332269
Pubmed

A comprehensive analysis of 22q11 gene expression in the developing and adult brain.

GGT2P GGT1 GGT3P

3.80e-054550314614146
Pubmed

Spindle Assembly Checkpoint Inhibition Can Resensitize p53-Null Stem Cells to Cancer Chemotherapy.

SPATA31A1 PVRIG SYT5 DYRK2

4.61e-0513750430862715
Pubmed

Neuropeptide Y receptor genes on human chromosome 4q31-q32 map to conserved linkage groups on mouse chromosomes 3 and 8.

NPY1R MYO9B

5.64e-0585029169155
Pubmed

A mutation in the pericentrin gene causes abnormal interneuron migration to the olfactory bulb in mice.

GGT2P GGT1 GGT3P

7.34e-055650320096683
Pubmed

Neuropeptide Y receptor genes mapped in human and mouse: receptors with high affinity for pancreatic polypeptide are not clustered with receptors specific for neuropeptide Y and peptide YY.

NPY1R MYO9B

1.32e-04125029417917
Pubmed

Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.

COL7A1 MYO9B DSTYK PIEZO1 CPLANE1 GGT3P

1.37e-0455250610737800
Pubmed

A vagal reflex evoked by airway closure.

NPY1R PIEZO1

2.40e-041650238448588
Pubmed

Multiple nonglycemic genomic loci are newly associated with blood level of glycated hemoglobin in East Asians.

MYO9B PIEZO1

2.72e-041750224647736
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

COL7A1 CHST14 PIEZO1 FURIN CNTNAP1 ELP6 ITGA5 R3HDM1

2.92e-04120150835696571
Pubmed

The planar cell polarity gene Vangl2 is required for mammalian kidney-branching morphogenesis and glomerular maturation.

GGT2P GGT1 GGT3P

3.53e-049550320843830
Pubmed

Report of the sixth international workshop on human chromosome 3 mapping 1995.

COL7A1 TRH

4.18e-04215028641130
Pubmed

Regulation of endodermal differentiation of human embryonic stem cells through integrin-ECM interactions.

COL7A1 ITGA5

9.77e-043250223154389
Pubmed

Protein interactome reveals converging molecular pathways among autism disorders.

PLEKHA4 SYT5 BEX4 R3HDM1 CPLANE1

1.24e-0356050521653829
Pubmed

Characterization of the Cardiac Overexpression of HSPB2 Reveals Mitochondrial and Myogenic Roles Supported by a Cardiac HspB2 Interactome.

AIFM1 BEX4 ACAD10

1.25e-0314750326465331
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

WEE1 DSTYK R3HDM1 MAP3K21 SYDE1 DYRK2

1.42e-0386150636931259
CytobandEnsembl 112 genes in cytogenetic band chr9q12

SPATA31A7 SPATA31A5

3.24e-058502chr9q12
Cytoband9p13.1

SPATA31A1 SPATA31A3

3.16e-04245029p13.1
CytobandEnsembl 112 genes in cytogenetic band chr22q11

SLC2A11 GGT2P GGT1 GGT3P

1.13e-03419504chr22q11
Cytoband22q11.23

SLC2A11 GGT1

1.55e-035350222q11.23
CytobandEnsembl 112 genes in cytogenetic band chr19q13

OVOL3 GGN PLEKHA4 APLP1 SYT5 BBC3

1.81e-031192506chr19q13
Cytoband22q11.21

GGT2P GGT3P

6.58e-0311150222q11.21
GeneFamilyCD molecules|Gamma-glutamyltransferases

GGT2P GGT1 GGT3P

6.62e-0713253564
CoexpressionGSE15324_NAIVE_VS_ACTIVATED_CD8_TCELL_UP

COL7A1 FBXL8 DSTYK ZNFX1 ACAD10 SYDE1

1.95e-06200496M3523
ToppCellFetal_29-31_weeks-Mesenchymal-matrix_fibroblast_2_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ADAMTS4 CNTNAP1 PLEKHA4 TNFAIP2 ARHGEF26

2.31e-061905050fea33f2dc1efa23aaa2da1c318482a52a313ff1
ToppCellFetal_29-31_weeks-Mesenchymal-chondrocyte-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

COL7A1 TRH ADAMTS4 TNFAIP2

2.62e-0515350465641cc82883716dba0fefb749a30174a63f4da5
ToppCellTCGA-Ovary-Primary_Tumor-Ovarian_Carcinoma-Serous_Cystadenocarcinoma-5|TCGA-Ovary / Sample_Type by Project: Shred V9

DSTYK ACAD10 CPLANE1 MAP3K21

3.61e-0516650432d2eaf8a5d03881bf74d680825af2d5110b082d
ToppCelldroplet-Pancreas-Exocrine-24m-Epithelial-pancreatic_acinar_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL7A1 CHST14 BBC3 GGT1

3.69e-051675043c06894fc6177f3c204094719904da42f08b9af8
ToppCellRSV-Healthy-1|Healthy / Virus stimulation, Condition and Cluster

ADAMTS4 MYO9B TBC1D2 SYT5

4.43e-05175504ff3a27f512a3a710ebc863b7b75cce8167d5440b
ToppCellRSV-Healthy-1|RSV / Virus stimulation, Condition and Cluster

ADAMTS4 MYO9B TBC1D2 SYT5

4.43e-05175504ca52b99b03535a5b3a2751d6981708dc5b255b91
ToppCellfacs-Marrow-KLS-18m-Lymphocytic-late_pro-B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PI4K2B ITGA5 TERT SYDE1

4.53e-051765043766e0533b103ec92ac75eba3df02e287efc53fa
ToppCellfacs-Marrow-KLS-18m-Lymphocytic-late_pro_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PI4K2B ITGA5 TERT SYDE1

4.53e-05176504aa1bada2175d8370fc71939a607407155259d195
ToppCellE16.5-Epithelial-Epithelial_Airway-Neurosecretory-PNEC-PNEC_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NPY1R APLP1 SYT5 VWA5B1

4.73e-05178504d3a75a8082e70543b84c35d53fe77625300d19fa
ToppCellE16.5-Epithelial-Epithelial_Airway-Neurosecretory-PNEC|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NPY1R APLP1 SYT5 VWA5B1

4.73e-05178504b2cda1df801b1a1a41e3dd2808baef37765cd804
ToppCellCalu_3-infected|Calu_3 / Cell line, Condition and Strain

COL7A1 PLEKHA4 ZNFX1 TNFAIP2

5.27e-051835048f7f5000645f24f20a8d7700c4df1f8953a1780b
ToppCellTCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-4|TCGA-Prostate / Sample_Type by Project: Shred V9

CNTNAP1 TBC1D2 TNFAIP2 SYDE1

6.74e-051955045562665dd3beb70e2358aa32611a337bef5731c1
ToppCell5'-Adult-Appendix|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ADAMTS4 TNFAIP2 ITGA5 FAM20A

6.88e-05196504a579211ef14f348d0c5a290553150222dfbf1515
ToppCellsevere-NK_CD56bright|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

METTL24 TRH FURIN BEX4

7.44e-052005042e67068b98696c313b815a2f0c98643f892e8bc0
DrugAminocaproic acid [60-32-2]; Down 200; 30.4uM; MCF7; HT_HG-U133A

MYO9B FURIN APLP1 TNFAIP2 BBC3 DYRK2

3.20e-061984766501_DN
Diseaseaflatoxins-related hepatocellular carcinoma (biomarker_via_orthology)

GGT2P GGT1 GGT3P

1.24e-077463DOID:5022 (biomarker_via_orthology)
Diseasealcohol dependence (biomarker_via_orthology)

GGT2P GGT1 GGT3P

1.97e-078463DOID:0050741 (biomarker_via_orthology)
Diseasegastric ulcer

MYO9B GGT1

4.90e-0421462EFO_0009454
Diseasediastolic blood pressure, unipolar depression

FURIN ACAD10

1.01e-0330462EFO_0003761, EFO_0006336
Diseasemelanoma (is_marker_for)

TERT GGT1

1.22e-0333462DOID:1909 (is_marker_for)
Diseaseplatelet measurement

MYO9B SYT5 ACAD10 TERT

1.46e-03315464EFO_0005036

Protein segments in the cluster

PeptideGeneStartEntry
RQEEQQRHRPSPWRV

BBC3

156

Q9BXH1
QLGRWVPRLREPRDL

AGBL3

61

Q8NEM8
QARLRVDHRPWVLRP

CNTNAP1

886

P78357
RRLVPNFRWAIPNRH

BEX4

56

Q9NWD9
RNRLPGNLFQRWHVP

AIFM1

31

O95831
HRDLRTGRWEPDPQR

APLP1

66

P51693
ERLIEWLPLHLPRQQ

ACAD10

441

Q6JQN1
PLWRRRSIPQPHQVL

ARHGEF26

16

Q96DR7
VHGQLRILWRRPSQP

ELP6

221

Q0PNE2
RILWRRPSQPAVHRD

ELP6

226

Q0PNE2
SGHLPRDPELRDWRR

ANO9

511

A1A5B4
RWLRDPQSQPRRHPL

R3HDM1

1016

Q15032
QRHGRLPWARLFQPS

GGT3P

146

A6NGU5
QPRHRRLPRNVSAWL

GGN

601

Q86UU5
LWNNVRRGARPERLP

DSTYK

861

Q6XUX3
REPLLPRIAWAHPRR

PI4K2B

26

Q8TCG2
LVRSRRPQPPNWGHL

OVOL3

6

O00110
VERHQLIINPRGWRP

NPY1R

136

P25929
LIINPRGWRPNNRHA

NPY1R

141

P25929
HAVQLRWGPRRRPPL

ITGA5

11

P08648
RPTPQDWLHRRAQIL

ADAMTS4

811

O75173
LHRLNFPRRAQGPTW

SLC2A11

471

Q9BYW1
NPVQQPGHRLLILWR

CPLANE1

756

Q9H799
PLPNEAWVALRRRHP

FBXL8

236

Q96CD0
RPRHSRLQREPQVQW

FURIN

81

P09958
HSLRLRWEPVPRAQG

COL7A1

881

Q02388
PGQALRHPWLRRRLP

DYRK2

526

Q92630
QRHGRLPWARLFQPS

GGT2P

146

P36268
GRPRRKGPRWHIDLQ

METTL24

101

Q5JXM2
ALVLAWDPGVRRHRP

SYDE1

331

Q6ZW31
RPIAQWHSLRPPDRV

SYT5

366

O00445
PRRARRIPPHVLVNW

MAP3K21

226

Q5TCX8
ALRRDPNLPVHIRGW

PLEKHA4

46

Q9H4M7
HLWPQVQRQLRPRER

FAM20A

26

Q96MK3
QHPEWPLLRRQLEGR

SPATA31A7

541

Q8IWB4
LRHTRQGWALRPVLP

SHBG

21

P04278
PWDLPVGQRRTLLRH

CHST14

126

Q8NCH0
QHPEWPLLRRQLEGR

SPATA31A3

541

Q5VYP0
EWGLARVAQPRLRQP

URGCP

571

Q8TCY9
RRWAEDVPPQRLDGH

TNFAIP2

341

Q03169
DQWHEIRQGRLPRIP

WEE1

521

P30291
QHPEWPLLRRQLEGR

SPATA31A1

541

Q5TZJ5
QHPEWPLLRRQLEGR

SPATA31A5

541

Q5VU36
GLRHPRINVLDPGQW

ZNFX1

576

Q9P2E3
RQHPGRRAAWVREPL

TRH

226

P20396
LPGTRLPRWAHRQDA

PIEZO1

716

Q92508
LHPERGIRQWAPARQ

PVRIG

91

Q6DKI7
RLVPPGLWGSRHNER

TERT

471

O14746
LLRAGVPREHRPRVW

TBC1D2

621

Q9BYX2
WVIRQPVHRGHPRLL

VWA5B1

446

Q5TIE3
QRHGRLPWARLFQPS

GGT1

146

P19440
HRVLLWPRRAQDEHP

MYO9B

86

Q13459