Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyCellularComponentspectrin-associated cytoskeleton

SPTBN1 SPTBN2

4.15e-059232GO:0014731
GeneOntologyCellularComponentspectrin

SPTBN1 SPTBN2

4.15e-059232GO:0008091
GeneOntologyCellularComponentcuticular plate

SNX9 SPTBN1

8.97e-0513232GO:0032437
GeneOntologyCellularComponentcortical actin cytoskeleton

SNX9 SPTBN1 SPTBN2

1.42e-0493233GO:0030864
GeneOntologyCellularComponentcortical cytoskeleton

SNX9 SPTBN1 SPTBN2

3.71e-04129233GO:0030863
GeneOntologyCellularComponentsperm flagellum

DNAH2 MROH2B SPEF2

1.61e-03214233GO:0036126
GeneOntologyCellularComponent9+2 motile cilium

DNAH2 MROH2B SPEF2

2.18e-03238233GO:0097729
GeneOntologyCellularComponentsperm midpiece

MROH2B SPEF2

2.24e-0364232GO:0097225
DomainSpectrin_bsu

SPTBN1 SPTBN2

8.69e-064232IPR016343
DomainPH_dom-spectrin-type

SPTBN1 SPTBN2

5.19e-059232IPR001605
DomainCH

SPEF2 SPTBN1 SPTBN2

9.59e-0573233PS50021
DomainCH-domain

SPEF2 SPTBN1 SPTBN2

1.04e-0475233IPR001715
DomainACTININ_2

SPTBN1 SPTBN2

3.61e-0423232PS00020
DomainActinin_actin-bd_CS

SPTBN1 SPTBN2

3.61e-0423232IPR001589
DomainACTININ_1

SPTBN1 SPTBN2

3.61e-0423232PS00019
DomainSpectrin

SPTBN1 SPTBN2

3.61e-0423232PF00435
DomainSpectrin_repeat

SPTBN1 SPTBN2

5.77e-0429232IPR002017
DomainSpectrin/alpha-actinin

SPTBN1 SPTBN2

7.04e-0432232IPR018159
DomainSPEC

SPTBN1 SPTBN2

7.04e-0432232SM00150
DomainCH

SPTBN1 SPTBN2

2.88e-0365232SM00033
DomainCH

SPTBN1 SPTBN2

3.33e-0370232PF00307
Domain-

SPTBN1 SPTBN2

3.42e-03712321.10.418.10
PathwayREACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS

SPTBN1 SPTBN2

5.41e-0510162MM15112
Pubmed

Caspase-3/7-mediated Cleavage of β2-spectrin is Required for Acetaminophen-induced Liver Damage.

SPTBN1 SPTBN2

4.56e-07224226884715
Pubmed

E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.

DNAH2 IVNS1ABP REXO4 SPTBN2 ACVR1B INTS1 CTPS1

4.67e-0773624729676528
Pubmed

Loss of β2-spectrin prevents cardiomyocyte differentiation and heart development.

SPTBN1 SPTBN2

2.74e-06424224064296
Pubmed

Apparent structural differences at the tetramerization region of erythroid and nonerythroid beta spectrin as discriminated by phage displayed scFvs.

SPTBN1 SPTBN2

2.74e-06424221412925
Pubmed

TGF-β/β2-spectrin/CTCF-regulated tumor suppression in human stem cell disorder Beckwith-Wiedemann syndrome.

SPTBN1 SPTBN2

4.56e-06524226784546
Pubmed

ST3GAL1 and βII-spectrin pathways control CAR T cell migration to target tumors.

SPTBN1 SPTBN2

6.83e-06624237069398
Pubmed

Cell organization, growth, and neural and cardiac development require αII-spectrin.

SPTBN1 SPTBN2

2.05e-051024222159418
Pubmed

Brain proteins interacting with the tetramerization region of non-erythroid alpha spectrin.

SPTBN1 SPTBN2

2.50e-051124217607528
Pubmed

mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis.

SNX9 SPTBN1 SPTBN2 CTPS1

3.54e-0527424434244482
Pubmed

alphaII-betaV spectrin bridges the plasma membrane and cortical lattice in the lateral wall of the auditory outer hair cells.

SPTBN1 SPTBN2

3.54e-051324218796539
Pubmed

Proteomic discovery of Max as a novel interacting partner of C/EBPalpha: a Myc/Max/Mad link.

ZNF45 SPTBN1

4.13e-051424217082780
Pubmed

The Tumor Suppressor CIC Directly Regulates MAPK Pathway Genes via Histone Deacetylation.

IVNS1ABP SNX9 SPTBN1 INTS1 CTPS1

4.25e-0558324529844126
Pubmed

Organization of focal adhesion plaques is disrupted by action of the HIV-1 protease.

SPTBN1 SPTBN2

6.94e-051824212119179
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

SNX9 REXO4 SPTBN1 SPTBN2 INTS1

7.26e-0565324522586326
Pubmed

Tumor suppressor BAP1 nuclear import is governed by transportin-1.

IVNS1ABP SNX9 PCYOX1L SPTBN1 SPTBN2 CTPS1

1.04e-04114924635446349
Pubmed

NDP52 interacts with mitochondrial RNA poly(A) polymerase to promote mitophagy.

SPTBN1 SPTBN2

1.36e-042524230309841
Pubmed

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.

MAP3K20 REXO4 SPTBN1 SPTBN2 COL17A1 CTPS1

1.69e-04125724636526897
Pubmed

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.

CCND3 MAP3K20 SNX9 ACVR1B INTS1

3.41e-0491024536736316
Pubmed

E-cadherin interactome complexity and robustness resolved by quantitative proteomics.

SNX9 SPTBN1 SPTBN2 COL17A1

5.66e-0456524425468996
InteractionRNF123 interactions

DNAH2 IVNS1ABP REXO4 SPTBN2 ACVR1B INTS1 CTPS1

2.57e-05824237int:RNF123
CytobandEnsembl 112 genes in cytogenetic band chr5p13

MROH2B SPEF2

2.40e-03139242chr5p13
CytobandEnsembl 112 genes in cytogenetic band chr6q25

SNX9 ULBP1

3.32e-03164242chr6q25
GeneFamilyEF-hand domain containing|Spectrins

SPTBN1 SPTBN2

1.54e-0571621113
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

SPTBN1 SPTBN2

1.40e-02206162682
CoexpressionMARZEC_IL2_SIGNALING_UP

CCND3 MAP3K20 ACVR1B CTPS1

3.49e-06115244M13984
CoexpressionELVIDGE_HYPOXIA_BY_DMOG_DN

CCND3 SLC24A3 CTPS1

2.12e-0559243M7030
CoexpressionELVIDGE_HIF1A_TARGETS_UP

CCND3 SLC24A3 CTPS1

3.11e-0567243M17905
ToppCellfacs-Tongue-nan-3m-Epithelial-nan|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MAP3K20 IVNS1ABP SPTBN1 COL17A1

3.68e-061992448d50e1ee58710d896c0204937331d9f4dcd38de0
ToppCellThalamus-Macroglia-POLYDENDROCYTE-P1-P1_1-Tnr-Polydendrocyte.Tnr.Ctps_(Ctps)|Thalamus / BrainAtlas - Mouse McCarroll V32

MROH2B CTPS1 TEX11

8.09e-06732430ea6106a85b31d037c9aa16e1ad6a9bcb5b2eda9
ToppCellThalamus-Macroglia-POLYDENDROCYTE-P1-P1_1-Tnr|Thalamus / BrainAtlas - Mouse McCarroll V32

MROH2B CTPS1 TEX11

8.09e-0673243f2361804ed2e052efc1236d8abfa39ab7cb68dd8
DrugResveratrol [501-36-0]; Up 200; 17.6uM; MCF7; HT_HG-U133A

ULBP1 SLC24A3 ZNF45 SPTBN1 ACVR1B

1.80e-061992455509_UP
DrugPiperacetazine [3819-00-9]; Down 200; 9.8uM; MCF7; HT_HG-U133A

CCND3 RAB3IL1 SLC24A3 SPTBN1 ACVR1B

1.80e-061992453574_DN
DrugSTOCK1N-35215; Down 200; 10uM; PC3; HT_HG-U133A

ZNF45 PCYOX1L ZNF302 COL17A1

4.66e-051932446427_DN
DrugTocopherol (R,S) [10191-41-0]; Up 200; 9.2uM; MCF7; HT_HG-U133A

SLC24A3 SPTBN1 ACVR1B COL17A1

4.95e-051962443256_UP
DrugBeta-Escin [11072-93-8]; Down 200; 3.2uM; MCF7; HT_HG-U133A

SLC24A3 ZNF45 SPTBN2 ACVR1B

5.04e-051972446050_DN
DrugEsculetin [305-01-1]; Up 200; 22.4uM; MCF7; HT_HG-U133A

RAB3IL1 ZNF45 SPTBN1 SPTBN2

5.04e-051972447459_UP
DrugTodralazine hydrochloride [3778-76-5]; Up 200; 14.8uM; MCF7; HT_HG-U133A

ULBP1 SLC24A3 SPTBN1 ACVR1B

5.04e-051972445512_UP
DrugDisulfiram [97-77-8]; Down 200; 13.4uM; PC3; HT_HG-U133A

RAB3IL1 ZNF45 SPTBN1 ACVR1B

5.14e-051982445729_DN
DrugADPribulose

SPTBN1 SPTBN2

8.25e-0513242CID000197570
Drugplakin

SPTBN1 SPTBN2 COL17A1

8.63e-0582243CID000018752
Diseasespinocerebellar ataxia type 5 (implicated_via_orthology)

SPTBN1 SPTBN2

3.48e-064232DOID:0050882 (implicated_via_orthology)
Diseasephosphatidylcholine 38:2 measurement

RAB3IL1 TMEM74

3.40e-0435232EFO_0010384
DiseaseUterine leiomyoma

DNAH2 TEX11

2.28e-0391232HP_0000131
Diseasemonocyte count

CCND3 CREBL2 SPEF2 SPTBN1 SPTBN2

3.05e-031320235EFO_0005091
Diseaset-tau measurement

SNX9 TMEM74

4.32e-03126232EFO_0004760
Diseasered blood cell density measurement

DNAH2 CCND3 SPTBN1 ACVR1B

4.43e-03880234EFO_0007978
DiseaseGlobal developmental delay

SPTBN2 INTS1

4.79e-03133232C0557874
Diseasemajor depressive disorder

SPTBN2 ACVR1B

6.45e-03155232MONDO_0002009
Diseasealkaline phosphatase measurement

SNX9 ZNF45 REXO4 SPTBN1

7.31e-031015234EFO_0004533
Diseasesexual dimorphism measurement

CCND3 TBC1D29P TMEM74 CTPS1

9.84e-031106234EFO_0021796
Diseaseuterine fibroid

DNAH2 TEX11

1.04e-02199232EFO_0000731

Protein segments in the cluster

PeptideGeneStartEntry
EELWMFVRKKLMMEQ

COL17A1

546

Q9UMD9
MRKMLAYWMLEVCEE

CCND3

56

P30281
LRVMGKMMRECWYAN

ACVR1B

466

P36896
AEPMFWEIMRLRKEM

RAB3IL1

356

Q8TBN0
AWEEYPTLKMLMEMV

INTS1

756

Q8N201
VEMYDPTRNEWKMMG

IVNS1ABP

576

Q9Y6Y0
MWVEEVMEKFMRIYK

PCYOX1L

146

Q8NBM8
LMDLVGEDRKWMMAR

SLC24A3

51

Q9HC58
REELEMYKQWCMAMD

CREBL2

66

O60519
KWKMYMEMDGDEIAI

MAP3K20

456

Q9NYL2
WMLYMIRLDRMMEDA

DNAH2

821

Q9P225
MRLYVMVKKEWESMA

REXO4

391

Q9GZR2
EEFIKMRMERLQAWM

SNX9

321

Q9Y5X1
LMEKWLGERYLNEMA

SPEF2

1391

Q9C093
MLMKWKEMADRYDRL

CTPS1

281

P17812
MDALGKLLKTMMWDN

MROH2B

866

Q7Z745
QKIFQEMLYIMDWMD

SPTBN1

531

Q01082
EMLYIMDWMDEMKVL

SPTBN1

536

Q01082
LYLMDWMEEMKGRLQ

SPTBN2

541

O15020
LIMMNMRIGKEWLDA

TEX11

121

Q8IYF3
WDMYLLEGEQMLMLI

TBC1D29P

36

Q9UFV1
KMWLEEFLMYWEQML

ULBP1

191

Q9BZM6
LSCLLMMSMWKGELY

TMEM74

246

Q96NL1
LPQLEREEKLWMMKM

ZNF45

56

Q02386
YVIMLLEDGKEPWMM

ZNF302

51

Q9NR11