Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	protein serine/threonine kinase activity	SPEG MINK1 OBSCN CCNK MAP3K5 MKNK1 TTBK2 PRKAB1 ALPK3 TAF1L MAP4K4 EIF2AK3	5.89e-06	446	109	12	GO:0004674
GeneOntologyMolecularFunction	protein kinase activity	SPEG MINK1 OBSCN CCNK MAP3K5 MKNK1 TTBK2 PRKAB1 ALPK3 TAF1L MAP4K4 EIF2AK3	1.07e-04	600	109	12	GO:0004672
GeneOntologyMolecularFunction	protein serine kinase activity	SPEG MINK1 OBSCN MAP3K5 MKNK1 TTBK2 ALPK3 MAP4K4 EIF2AK3	1.69e-04	363	109	9	GO:0106310
GeneOntologyMolecularFunction	L-lactate dehydrogenase activity	LDHAL6B LDHC	2.92e-04	5	109	2	GO:0004459
GeneOntologyMolecularFunction	lactate dehydrogenase activity	LDHAL6B LDHC	4.37e-04	6	109	2	GO:0004457
GeneOntologyMolecularFunction	phosphotransferase activity, alcohol group as acceptor	SPEG MINK1 OBSCN CCNK MAP3K5 MKNK1 TTBK2 PRKAB1 ALPK3 TAF1L MAP4K4 EIF2AK3	4.92e-04	709	109	12	GO:0016773
GeneOntologyMolecularFunction	transferase activity, transferring phosphorus-containing groups	SPEG POLR2C MINK1 CGAS OBSCN CCNK MAP3K5 MKNK1 TTBK2 PRKAB1 ALPK3 TAF1L MAP4K4 EIF2AK3	5.82e-04	938	109	14	GO:0016772
GeneOntologyMolecularFunction	clathrin light chain binding	CLTCL1 CLTC	6.09e-04	7	109	2	GO:0032051
GeneOntologyMolecularFunction	kinase activity	SPEG MINK1 OBSCN CCNK MAP3K5 MKNK1 TTBK2 PRKAB1 ALPK3 TAF1L MAP4K4 EIF2AK3	9.47e-04	764	109	12	GO:0016301
Domain	Clathrin_H-chain_propeller_rpt	CLTCL1 CLTC	3.25e-05	2	107	2	IPR022365
Domain	Clathrin-link	CLTCL1 CLTC	3.25e-05	2	107	2	PF09268
Domain	-	CLTCL1 CLTC	3.25e-05	2	107	2	2.130.10.110
Domain	Clathrin_heavy_chain	CLTCL1 CLTC	3.25e-05	2	107	2	IPR016341
Domain	Clathrin_H-chain_propeller_N	CLTCL1 CLTC	3.25e-05	2	107	2	IPR001473
Domain	Clathrin_H-chain_link/propller	CLTCL1 CLTC	3.25e-05	2	107	2	IPR016025
Domain	Clathrin_propel	CLTCL1 CLTC	3.25e-05	2	107	2	PF01394
Domain	Clathrin_H-chain_linker_core	CLTCL1 CLTC	3.25e-05	2	107	2	IPR015348
Domain	Clathrin_H-chain_linker	CLTCL1 CLTC	9.72e-05	3	107	2	IPR012331
Domain	CBF	CEBPZ NOC4L	9.72e-05	3	107	2	PF03914
Domain	CCAAT-binding_factor	CEBPZ NOC4L	9.72e-05	3	107	2	IPR005612
Domain	CLH	CLTCL1 CLTC	9.72e-05	3	107	2	SM00299
Domain	BAAT_C	ACOT6 ACOT4	3.22e-04	5	107	2	IPR014940
Domain	L_LDH	LDHAL6B LDHC	3.22e-04	5	107	2	PS00064
Domain	L-lactate_DH	LDHAL6B LDHC	3.22e-04	5	107	2	IPR011304
Domain	L-lactate_DH_AS	LDHAL6B LDHC	3.22e-04	5	107	2	IPR018177
Domain	BAAT_C	ACOT6 ACOT4	3.22e-04	5	107	2	PF08840
Domain	Clathrin	CLTCL1 CLTC	6.70e-04	7	107	2	PF00637
Domain	Cullin_CS	CUL9 CUL5	6.70e-04	7	107	2	IPR016157
Domain	CHCR	CLTCL1 CLTC	6.70e-04	7	107	2	PS50236
Domain	Ig_I-set	DSCAM SPEG OBSCN HMCN1 ALPK3 CNTN2	7.91e-04	190	107	6	IPR013098
Domain	I-set	DSCAM SPEG OBSCN HMCN1 ALPK3 CNTN2	7.91e-04	190	107	6	PF07679
Domain	Clathrin_H-chain/VPS_repeat	CLTCL1 CLTC	8.90e-04	8	107	2	IPR000547
Domain	Cullin_neddylation_domain	CUL9 CUL5	8.90e-04	8	107	2	IPR019559
Domain	Lactate/malate_DH_N	LDHAL6B LDHC	8.90e-04	8	107	2	IPR001236
Domain	Cullin_Nedd8	CUL9 CUL5	8.90e-04	8	107	2	PF10557
Domain	L-lactate/malate_DH	LDHAL6B LDHC	8.90e-04	8	107	2	IPR001557
Domain	Cullin_Nedd8	CUL9 CUL5	8.90e-04	8	107	2	SM00884
Domain	Ldh_1_N	LDHAL6B LDHC	8.90e-04	8	107	2	PF00056
Domain	S_TKc	SPEG MINK1 OBSCN MAP3K5 MKNK1 TTBK2 MAP4K4 EIF2AK3	1.08e-03	359	107	8	SM00220
Domain	PROTEIN_KINASE_ST	SPEG MINK1 OBSCN MAP3K5 MKNK1 TTBK2 MAP4K4 EIF2AK3	1.14e-03	362	107	8	PS00108
Domain	-	LDHAL6B LDHC	1.14e-03	9	107	2	3.90.110.10
Domain	Lactate/malate_DH_C	LDHAL6B LDHC	1.14e-03	9	107	2	IPR022383
Domain	Ldh_1_C	LDHAL6B LDHC	1.14e-03	9	107	2	PF02866
Domain	Cullin_homology	CUL9 CUL5	1.14e-03	9	107	2	IPR016158
Domain	Lactate_DH/Glyco_Ohase_4_C	LDHAL6B LDHC	1.14e-03	9	107	2	IPR015955
Domain	Cullin	CUL9 CUL5	1.42e-03	10	107	2	PF00888
Domain	CULLIN_2	CUL9 CUL5	1.42e-03	10	107	2	PS50069
Domain	Cullin_N	CUL9 CUL5	1.42e-03	10	107	2	IPR001373
Domain	CULLIN_1	CUL9 CUL5	1.42e-03	10	107	2	PS01256
Domain	Protein_kinase_ATP_BS	SPEG MINK1 OBSCN MAP3K5 MKNK1 TTBK2 MAP4K4 EIF2AK3	1.52e-03	379	107	8	IPR017441
Domain	Pkinase	SPEG MINK1 OBSCN MAP3K5 MKNK1 TTBK2 MAP4K4 EIF2AK3	1.57e-03	381	107	8	PF00069
Domain	IGc2	DSCAM SPEG OBSCN HMCN1 ALPK3 CNTN2	2.34e-03	235	107	6	SM00408
Domain	Ig_sub2	DSCAM SPEG OBSCN HMCN1 ALPK3 CNTN2	2.34e-03	235	107	6	IPR003598
Domain	CNH	MINK1 MAP4K4	2.83e-03	14	107	2	SM00036
Domain	CNH	MINK1 MAP4K4	3.25e-03	15	107	2	PF00780
Domain	CNH	MINK1 MAP4K4	3.25e-03	15	107	2	PS50219
Domain	CNH_dom	MINK1 MAP4K4	3.25e-03	15	107	2	IPR001180
Domain	Kinase-like_dom	SPEG MINK1 OBSCN MAP3K5 MKNK1 TTBK2 ALPK3 MAP4K4 EIF2AK3	3.95e-03	542	107	9	IPR011009
Domain	Ser/Thr_kinase_AS	SPEG MINK1 OBSCN MAP3K5 MKNK1 MAP4K4 EIF2AK3	4.48e-03	357	107	7	IPR008271
Domain	Kelch	KBTBD6 KLHL9 KLHDC10	4.49e-03	58	107	3	SM00612
Domain	-	DPP6 ACOT6 ACOT4 CES3	4.88e-03	119	107	4	3.40.50.1820
Domain	AB_hydrolase	DPP6 ACOT6 ACOT4 CES3	4.88e-03	119	107	4	IPR029058
Domain	PROTEIN_KINASE_ATP	SPEG MINK1 OBSCN MAP3K5 MKNK1 TTBK2 MAP4K4 EIF2AK3	4.90e-03	459	107	8	PS00107
Domain	Pyr_redox_2	ETFDH DLD	5.22e-03	19	107	2	PF07992
Domain	RhoGAP	INPP5B ARHGAP39 FAM13B	5.41e-03	62	107	3	SM00324
Domain	RhoGAP	INPP5B ARHGAP39 FAM13B	5.66e-03	63	107	3	PF00620
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	GTPBP4 RANBP2 SF3A1 CUL9 NUP214 ACTN1 PRPF8 CEBPZ CLTC XRN1 USP7 DLD NOC4L PDS5A DDX24 PRRC2B	2.36e-10	653	109	16	22586326
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	RANBP2 SF3A1 MINK1 CHD3 NUP214 ARHGAP39 RRBP1 CCNK FANCD2 ESYT2 CHTF18 SVIL CLTC USP7 DDX24 MAP4K4 DYNC1LI2	3.28e-10	774	109	17	15302935
Pubmed	A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies.	SF3A1 ARHGEF12 NUP214 CUL5 CCDC112 GVINP1 MICALL2 CHTF18 CLTC MAP4K4 DYNC1LI2	1.68e-09	284	109	11	29459677
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	HBS1L RANBP2 SF3A1 MINK1 ARHGEF12 NUP214 ARHGAP39 RRBP1 CCNK ESYT2 XRN1 PDS5A MAP4K4 EIF2AK3 GOLGB1	6.39e-09	708	109	15	39231216
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	GTPBP4 HBS1L RANBP2 RRM2B POLR2C NUP214 RRBP1 SRCAP CEBPZ CHTF18 CLTC EIF2AK3	1.50e-08	440	109	12	34244565
Pubmed	Human transcription factor protein interaction networks.	DPF1 GTPBP4 KBTBD6 WDR33 GON4L CUL9 CHD3 NUP214 BRMS1L SRCAP ATXN2 SVIL XRN1 USP7 DLD NOC4L PDS5A DDX24 TAF1L PRRC2B	1.81e-08	1429	109	20	35140242
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	HBS1L RANBP2 POLR2C MINK1 ARHGEF12 GON4L ACTN1 ARHGAP39 CCNK ESYT2 MICALL2 ATXN2 CEBPZ XRN1 USP7 NOC4L PDS5A TAF1L FHIP1A GOLGB1	3.89e-08	1497	109	20	31527615
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	DPF1 GTPBP4 RANBP2 WDR33 SF3A1 POLR2C ARHGAP39 SRCAP PRPF8 CCNK CLTC USP7 NOC4L PDS5A DDX24 MAP4K4 DYNC1LI2	4.69e-08	1082	109	17	38697112
Pubmed	Two-Dimensional Fractionation Method for Proteome-Wide Cross-Linking Mass Spectrometry Analysis.	GTPBP4 DPYSL3 CLTCL1 WDR33 SF3A1 CHD3 ACTN1 NKIRAS2 SRCAP PRPF8 CLTC DLD MAP4K4 GOLGB1 DYNC1LI2	6.75e-08	847	109	15	35235311
Pubmed	TIF1γ inhibits lung adenocarcinoma EMT and metastasis by interacting with the TAF15/TBP complex.	RANBP2 SF3A1 ACTN1 RRBP1 PRPF8 CLTC USP7 GOLGB1	1.03e-07	179	109	8	36261009
Pubmed	Regulation of epidermal differentiation through KDF1-mediated deubiquitination of IKKα.	GTPBP4 RANBP2 WDR33 PRPF8 ATXN2 XRN1 USP7 MAP4K4	1.17e-07	182	109	8	32239614
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	GTPBP4 RANBP2 SF3A1 CHD3 NUP214 ACTN1 RRBP1 SRCAP PRPF8 CEBPZ SVIL CLTC NOC4L MAP4K4 NEURL4 GOLGB1	1.31e-07	1024	109	16	24711643
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	HBS1L DPYSL3 WDR33 ACTN1 SRCAP CCNK CEBPZ CLTC XRN1 USP7 MAP4K4 PRRC2B	1.66e-07	549	109	12	38280479
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	RANBP2 DPYSL3 POLR2C MINK1 ARHGAP39 FANCD2 PTP4A2 ESYT2 ATXN2 CEBPZ SVIL CLTC USP7 NOC4L NEURL4 PRRC2B	1.81e-07	1049	109	16	27880917
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	GTPBP4 RANBP2 DPYSL3 SF3A1 CHD3 NUP214 RRBP1 SRCAP PRPF8 CCNK XRN1 USP7 DLD GOLGB1 PRRC2B	2.36e-07	934	109	15	33916271
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	GTPBP4 HBS1L RANBP2 SF3A1 POLR2C ACTN1 FNBP1L RRBP1 PRPF8 CTPS2 CEBPZ CHTF18 CLTC USP7 PDS5A KLHDC10 DDX24 GOLGB1	4.16e-07	1415	109	18	28515276
Pubmed	WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage.	RANBP2 WDR33 GON4L CHD3 BRMS1L RRBP1 SRCAP USP7 PDS5A DDX24	4.89e-07	394	109	10	27248496
Pubmed	Large-scale mapping of human protein-protein interactions by mass spectrometry.	GTPBP4 RANBP2 WDR33 SF3A1 RRBP1 PRPF8 CUL5 PTP4A2 TTBK2 ATXN2 RASGRP3 PRKAB1 CLTC USP7 PDS5A DDX24 NEURL4	5.24e-07	1284	109	17	17353931
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	RANBP2 CLTCL1 WDR33 NUCB2 CHD3 ACTN1 FNBP1L RRBP1 NKIRAS2 SRCAP PRPF8 CEBPZ CLTC XRN1 CES3 DLD GOLGB1 PRRC2B	5.47e-07	1442	109	18	35575683
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	GTPBP4 RANBP2 WDR33 SF3A1 POLR2C CHD3 NUP214 BRMS1L RRBP1 SRCAP PRPF8 ESYT2 CEBPZ USP7 PDS5A DDX24 TAF1L	5.83e-07	1294	109	17	30804502
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	GTPBP4 MINK1 GON4L PRPF8 CLTC USP7 DDX24 GOLGB1	7.89e-07	234	109	8	36243803
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	GTPBP4 HBS1L RANBP2 POLR2C CGAS NUP214 ACTN1 RRBP1 SRCAP PRPF8 CEBPZ CHTF18 CLTC XRN1 USP7 PDS5A DDX24	1.07e-06	1353	109	17	29467282
Pubmed	Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.	RANBP2 SF3A1 CHD3 NUP214 SRCAP PRPF8 CLTC USP7 PDS5A	1.09e-06	332	109	9	32786267
Pubmed	The PHLPP1 N-Terminal Extension Is a Mitotic Cdk1 Substrate and Controls an Interactome Switch.	RANBP2 CHD3 NUP214 RRBP1 PRPF8 CLTC XRN1 GOLGB1	1.55e-06	256	109	8	33397691
Pubmed	Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.	GTPBP4 RANBP2 WDR33 SF3A1 NUP214 RRBP1 PRPF8 CEBPZ CHTF18 SVIL CLTC XRN1 USP7 DLD DDX24 DYNC1LI2	1.76e-06	1247	109	16	27684187
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	RANBP2 WDR33 SF3A1 CHD3 NUP214 RRBP1 PRPF8 CCNK ATXN2 CEBPZ CLTC PDS5A DDX24 TAF1L	1.78e-06	954	109	14	36373674
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	GTPBP4 RANBP2 DSCAM MINK1 ARHGEF12 ARHGAP39 MAP3K5 ATXN2 SVIL CLTC MAP4K4 NEURL4 GOLGB1 PRRC2B	1.98e-06	963	109	14	28671696
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	GTPBP4 HBS1L RANBP2 SF3A1 NUP214 RRBP1 PRPF8 LAP3 FANCD2 CEBPZ CLTC USP7 DLD NOC4L PDS5A DDX24 MAP4K4	2.17e-06	1425	109	17	30948266
Pubmed	Spatial proteomics reveal that the protein phosphatase PTP1B interacts with and may modify tyrosine phosphorylation of the rhomboid protease RHBDL4.	RANBP2 NUP214 RRBP1 ESYT2 XRN1 EIF2AK3 GOLGB1	2.51e-06	191	109	7	31177093
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	HBS1L RANBP2 DPYSL3 ESYT2 KLHL9 SVIL XRN1 DLD MAP4K4 NEURL4 FHIP1A PRRC2B DYNC1LI2	2.84e-06	853	109	13	28718761
Pubmed	RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.	RANBP2 CLTCL1 DSCAM CHD3 RRBP1 PRPF8 CLTC	3.63e-06	202	109	7	24639526
Pubmed	Defining the membrane proteome of NK cells.	GTPBP4 HBS1L RANBP2 CLTCL1 PRPF8 ESYT2 ATXN2 CHTF18 ENTPD1 CLTC XRN1 DDX24 EIF2AK3 GOLGB1 DYNC1LI2	3.78e-06	1168	109	15	19946888
Pubmed	Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair.	HBS1L RANBP2 KBTBD6 SF3A1 POLR2C CHD3 ACTN1 RRBP1 PRPF8 FANCD2 CUL5 CTPS2 CLTC USP7 DLD DDX24	4.21e-06	1335	109	16	29229926
Pubmed	Mapping the MOB proteins' proximity network reveals a unique interaction between human MOB3C and the RNase P complex.	RANBP2 MINK1 ACTN1 ESYT2 CLTC USP7 PDS5A DDX24 MAP4K4	4.88e-06	399	109	9	37536630
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	SPEG VPS8 ARHGEF12 GON4L CUL9 NUP214 CLTC SEL1L3 PRRC2B	5.73e-06	407	109	9	12693553
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	HBS1L MINK1 GON4L CHD3 RRBP1 DENND3 CUL5 CHTF18 XRN1 MAP4K4 PRRC2B	6.54e-06	650	109	11	38777146
Pubmed	Global mapping of herpesvirus-host protein complexes reveals a transcription strategy for late genes.	DPYSL3 WDR33 POLR2C GPX4 CHD3 NUP214 KLHL9 USP7 NEURL4 DYNC1LI2	7.22e-06	533	109	10	25544563
Pubmed	Charting the landscape of tandem BRCT domain-mediated protein interactions.	WDR33 SF3A1 POLR2C CCNK LDHC LAP3 ESYT2 ATXN2 CLTC DDX24 MAP4K4	8.69e-06	670	109	11	22990118
Pubmed	Characterization of a second human clathrin heavy chain polypeptide gene (CLH-22) from chromosome 22q11.	CLTCL1 CLTC	9.73e-06	2	109	2	8733129
Pubmed	Orthologous relationship of obscurin and Unc-89: phylogeny of a novel family of tandem myosin light chain kinases.	SPEG OBSCN	9.73e-06	2	109	2	15185077
Pubmed	KLHDC10 Deficiency Protects Mice against TNFα-Induced Systemic Inflammation.	MAP3K5 KLHDC10	9.73e-06	2	109	2	27631783
Pubmed	CHC22 and CHC17 clathrins have distinct biochemical properties and display differential regulation and function.	CLTCL1 CLTC	9.73e-06	2	109	2	29097553
Pubmed	The clathrin heavy chain isoform CHC22 functions in a novel endosomal sorting step.	CLTCL1 CLTC	9.73e-06	2	109	2	20065094
Pubmed	Novelty of the pyruvate metabolic enzyme dihydrolipoamide dehydrogenase in spermatozoa: correlation of its localization, tyrosine phosphorylation, and activity during sperm capacitation.	GPX4 DLD	9.73e-06	2	109	2	15888450
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	DPP6 DPYSL3 MINK1 ARHGEF12 CHD3 ACTN1 ARHGAP39 RRBP1 CUL5 SVIL CLTC XRN1 USP7 DLD CNTN2 PRRC2B	1.00e-05	1431	109	16	37142655
Pubmed	Network organization of the human autophagy system.	KBTBD6 SF3A1 LAP3 MAP3K5 ESYT2 PRKAB1 CLTC USP7 KLHDC10	1.01e-05	437	109	9	20562859
Pubmed	Endogenous Cell Type-Specific Disrupted in Schizophrenia 1 Interactomes Reveal Protein Networks Associated With Neurodevelopmental Disorders.	ACTN1 RRBP1 SVIL USP7 NOC4L MAP4K4	1.02e-05	156	109	6	29961565
Pubmed	Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression.	GTPBP4 NUP214 CEBPZ SVIL XRN1 USP7 NOC4L DDX24	1.04e-05	332	109	8	25693804
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	GTPBP4 RANBP2 CLTCL1 VPS8 CGAS PRPF8 FANCD2 CUL5 ESYT2 CEBPZ CLTC USP7 NOC4L PDS5A DDX24 PRRC2B	1.08e-05	1440	109	16	30833792
Pubmed	In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators.	GTPBP4 SPEG SF3A1 ARHGEF12 RRBP1 PRPF8 CCNK ATXN2 CEBPZ USP7 NOC4L PDS5A DDX24	1.14e-05	971	109	13	33306668
Pubmed	PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry.	WDR33 SF3A1 PRPF8 CHTF18 CLTC XRN1 USP7 PDS5A	1.24e-05	340	109	8	24332808
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	GTPBP4 HBS1L RANBP2 SF3A1 CGAS NUP214 RRBP1 PRPF8 LAP3 ESYT2 CEBPZ CLTC DLD NOC4L DDX24	1.59e-05	1318	109	15	30463901
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	GTPBP4 SF3A1 MINK1 NUCB2 RRBP1 PRPF8 ESYT2 CEBPZ CLTC DLD NOC4L DDX24 MAP4K4 EIF2AK3 NEURL4 GOLGB1	1.61e-05	1487	109	16	33957083
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	DPP6 MINK1 NUCB2 OBSCN CHD3 ARHGAP39 FNBP1L RRBP1 CUL5 PCNX2 ESYT2 KLHL9 ATXN2 ENTPD1 SEL1L3 GOLGB1	1.64e-05	1489	109	16	28611215
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	KBTBD6 SF3A1 GPX4 NUP214 PRPF8 CUL5 KLHL9 CTPS2 USP7 DDX24 MAP4K4 NEURL4 PRRC2B	1.64e-05	1005	109	13	19615732
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	WDR33 POLR2C CUL9 FNBP1L SRCAP CLTC USP7 DLD GOLGB1 PRRC2B	1.68e-05	588	109	10	38580884
Pubmed	RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.	RANBP2 ATXN2 SVIL XRN1 MAP4K4 GOLGB1 PRRC2B	2.02e-05	263	109	7	34702444
Pubmed	The DNA sequence and biological annotation of human chromosome 1.	CENPL INPP5B OBSCN GON4L DRAM2 FNBP1L ATP13A2 MKNK1 PTP4A2 VPS13D PIGC HMCN1 CNTN2	2.14e-05	1031	109	13	16710414
Pubmed	The ubiquitin-specific protease USP36 SUMOylates EXOSC10 and promotes the nucleolar RNA exosome function in rRNA processing.	GTPBP4 RANBP2 RRBP1 PRPF8 CEBPZ CLTC USP7 NOC4L DDX24	2.23e-05	483	109	9	36912080
Pubmed	Transcription factor Foxp3 and its protein partners form a complex regulatory network.	GTPBP4 RANBP2 WDR33 NUP214 ATXN2 CEBPZ NOC4L TAF1L	2.27e-05	370	109	8	22922362
Pubmed	Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray.	CUL9 PRPF8 MKNK1 SVIL CLTC SEL1L3 EIF2AK3 PRRC2B	2.31e-05	371	109	8	15747579
Pubmed	A human MAP kinase interactome.	RANBP2 NUP214 ACTN1 FAM13B MAP3K5 MKNK1 CLTC MAP4K4 GOLGB1	2.34e-05	486	109	9	20936779
Pubmed	Generalization of variants identified by genome-wide association studies for electrocardiographic traits in African Americans.	DPP6 HMCN1 FGFBP2	2.36e-05	18	109	3	23534349
Pubmed	Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.	RANBP2 SF3A1 RRM2B NUP214 ACTN1 FNBP1L PRPF8 LAP3 ESYT2 CHTF18 CLTC DLD DDX24 GOLGB1 PRRC2B	2.43e-05	1367	109	15	32687490
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	HBS1L ARHGAP39 DENND3 VPS13D RASGRP3 ZNF616 PDS5A KLHDC10 NEURL4	2.62e-05	493	109	9	15368895
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	SPEG OBSCN NUP214 RRBP1 PRPF8 VPS13D USP7 DDX24 MAP4K4	2.79e-05	497	109	9	36774506
Pubmed	Functional equivalence of the clathrin heavy chains CHC17 and CHC22 in endocytosis and mitosis.	CLTCL1 CLTC	2.91e-05	3	109	2	19509056
Pubmed	DSCAM functions as a netrin receptor in commissural axon pathfinding.	DSCAM CNTN2	2.91e-05	3	109	2	19196994
Pubmed	Clathrin promotes centrosome integrity in early mitosis through stabilization of centrosomal ch-TOG.	CLTCL1 CLTC	2.91e-05	3	109	2	22891263
Pubmed	Junctional Rab13-binding protein (JRAB) regulates cell spreading via filamins.	ACTN1 MICALL2	2.91e-05	3	109	2	23890175
Pubmed	Supervillin-mediated suppression of p53 protein enhances cell survival.	SVIL USP7	2.91e-05	3	109	2	23382381
Pubmed	A non-canonical cGAS-STING-PERK pathway facilitates the translational program critical for senescence and organ fibrosis.	CGAS EIF2AK3	2.91e-05	3	109	2	35501370
Pubmed	Clathrin isoform CHC22, a component of neuromuscular and myotendinous junctions, binds sorting nexin 5 and has increased expression during myogenesis and muscle regeneration.	CLTCL1 CLTC	2.91e-05	3	109	2	15133132
Pubmed	A Noc complex specifically involved in the formation and nuclear export of ribosomal 40 S subunits.	CEBPZ NOC4L	2.91e-05	3	109	2	12446671
Pubmed	A PH domain within OCRL bridges clathrin-mediated membrane trafficking to phosphoinositide metabolism.	INPP5B CLTC	2.91e-05	3	109	2	19536138
Pubmed	The Kelch repeat protein KLHDC10 regulates oxidative stress-induced ASK1 activation by suppressing PP5.	MAP3K5 KLHDC10	2.91e-05	3	109	2	23102700
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	GTPBP4 RANBP2 NUP214 ACTN1 PRPF8 ESYT2 CLTC USP7 NOC4L PDS5A	3.37e-05	638	109	10	33239621
Pubmed	The functional interactome landscape of the human histone deacetylase family.	WDR33 SF3A1 CHD3 BRMS1L CEBPZ SVIL USP7	3.68e-05	289	109	7	23752268
Pubmed	Proteomic analysis of a detergent-resistant membrane skeleton from neutrophil plasma membranes.	ACTN1 SVIL CLTC	3.82e-05	21	109	3	12202484
Pubmed	Proteomic characterization of chromosomal common fragile site (CFS)-associated proteins uncovers ATRX as a regulator of CFS stability.	GTPBP4 RANBP2 SF3A1 POLR2C PRPF8 FANCD2 CEBPZ SVIL CLTC PDS5A	4.04e-05	652	109	10	31180492
Pubmed	SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.	GTPBP4 RANBP2 CHD3 NUP214 RRBP1 PRPF8 ESYT2 DLD DDX24 PRRC2B	4.20e-05	655	109	10	35819319
Pubmed	Diverse functions of myosin VI elucidated by an isoform-specific α-helix domain.	GTPBP4 ARHGEF12 CLTC	4.42e-05	22	109	3	26950368
Pubmed	ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents.	GTPBP4 RANBP2 CGAS NUP214 ACTN1 PRPF8 SVIL CLTC USP7 DLD	4.47e-05	660	109	10	32780723
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	GTPBP4 WDR33 SF3A1 RRBP1 PRPF8 ATXN2 CEBPZ CLTC XRN1 DDX24 PRRC2B	4.78e-05	807	109	11	22681889
Pubmed	Quantitative proteomics reveals that long non-coding RNA MALAT1 interacts with DBC1 to regulate p53 acetylation.	WDR33 SF3A1 POLR2C PRPF8 NOC4L	5.57e-05	129	109	5	28973437
Pubmed	Hyperubiquitylation of wild-type p53 contributes to cytoplasmic sequestration in neuroblastoma.	CUL9 USP7	5.82e-05	4	109	2	17380154
Pubmed	Ursolic acid induces ER stress response to activate ASK1-JNK signaling and induce apoptosis in human bladder cancer T24 cells.	MAP3K5 EIF2AK3	5.82e-05	4	109	2	23000344
Pubmed	HIP1 functions in clathrin-mediated endocytosis through binding to clathrin and adaptor protein 2.	CLTCL1 CLTC	5.82e-05	4	109	2	11517213
Pubmed	Comparative interactome analysis of α-arrestin families in human and Drosophila.	WDR33 CUL9 FANCD2 ESYT2 SVIL MAP4K4 NEURL4	6.08e-05	313	109	7	38270169
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	GTPBP4 WDR33 BRMS1L RRBP1 FANCD2 ESYT2 VPS13D ATXN2 CLTC NOC4L DDX24 EIF2AK3 NEURL4 GOLGB1 PRRC2B	6.77e-05	1496	109	15	32877691
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	RANBP2 SF3A1 NUP214 RRBP1 PRPF8 TTBK2 MICALL2 SVIL CLTC PDS5A NEURL4 PRRC2B DYNC1LI2	6.84e-05	1155	109	13	20360068
Pubmed	The protein interaction landscape of the human CMGC kinase group.	HBS1L RANBP2 WDR33 EPB41L4A PRPF8 MKNK1 FANCD2 ESYT2 USP7 NEURL4	6.87e-05	695	109	10	23602568
Pubmed	KAP1 facilitates reinstatement of heterochromatin after DNA replication.	RANBP2 WDR33 PRPF8 LAP3 FANCD2 CTPS2 CEBPZ CLTC PDS5A DDX24	7.64e-05	704	109	10	29955894
Pubmed	Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis.	RANBP2 INPP5B NUP214 RRBP1 ESYT2 VPS13D PIGC XRN1 EIF2AK3	7.78e-05	568	109	9	37774976
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	RANBP2 SF3A1 CUL9 BRMS1L FNBP1L RRBP1 PRPF8 ESYT2 PDS5A DDX24 EIF2AK3	8.17e-05	857	109	11	25609649
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	GTPBP4 RANBP2 POLR2C CHD3 RRBP1 PRPF8 CCNK FANCD2 CUL5 CHTF18 USP7 PDS5A	8.28e-05	1014	109	12	32416067
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	GTPBP4 RANBP2 WDR33 SF3A1 CHD3 PRPF8 FANCD2 GOLGB1 DYNC1LI2	9.36e-05	582	109	9	20467437
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	RANBP2 MINK1 FNBP1L RRBP1 PRPF8 ATXN2 CEBPZ XRN1 DDX24 PRRC2B	9.62e-05	724	109	10	36232890
Pubmed	A giant nucleopore protein that binds Ran/TC4.	RANBP2 NUP214	9.67e-05	5	109	2	7603572
Pubmed	Fanconi anemia DNA crosslink repair factors protect against LINE-1 retrotransposition during mouse development.	CGAS FANCD2	9.67e-05	5	109	2	37580626
Interaction	SIRT6 interactions	GTPBP4 HBS1L RANBP2 RRM2B POLR2C CHD3 NUP214 ACTN1 RRBP1 SRCAP PRPF8 CEBPZ CHTF18 CLTC USP7 PDS5A EIF2AK3	3.92e-08	628	108	17	int:SIRT6
Interaction	SIRT7 interactions	GTPBP4 RANBP2 SF3A1 CUL9 NUP214 ACTN1 PRPF8 CEBPZ CLTC XRN1 USP7 DLD NOC4L PDS5A DDX24 PRRC2B	2.17e-06	744	108	16	int:SIRT7
Interaction	NXT2 interactions	RANBP2 NUP214 CUL5 KLHL9 USP7	5.74e-06	48	108	5	int:NXT2
Interaction	KDF1 interactions	GTPBP4 RANBP2 WDR33 PRPF8 ATXN2 XRN1 USP7 MAP4K4	9.16e-06	192	108	8	int:KDF1
Interaction	ACTN1 interactions	DSCAM ACTN1 FANCD2 CTPS2 MICALL2 ATXN2 SVIL CLTC DLD GOLGB1	1.50e-05	341	108	10	int:ACTN1
Interaction	TEDC2 interactions	SF3A1 ARHGEF12 CUL5 MICALL2 CHTF18 CLTC MAP4K4 DYNC1LI2	1.53e-05	206	108	8	int:TEDC2
Interaction	RPS6 interactions	GTPBP4 CHD3 ACTN1 RRBP1 PRPF8 FANCD2 CUL5 GVINP1 MICALL2 ATXN2 CEBPZ XRN1 USP7 NOC4L DDX24 GOLGB1	1.65e-05	874	108	16	int:RPS6
Interaction	PRDX4 interactions	ARHGEF12 ACTN1 ARHGAP39 PRPF8 FANCD2 PTP4A2 CLTC USP7	2.01e-05	214	108	8	int:PRDX4
Interaction	RAB5A interactions	GTPBP4 INPP5B MINK1 VPS8 RRBP1 ATP13A2 MKNK1 FANCD2 ESYT2 DDX24 EIF2AK3 NEURL4 FHIP1A GOLGB1	2.46e-05	706	108	14	int:RAB5A
Interaction	NXF1 interactions	RANBP2 CLTCL1 WDR33 SF3A1 ETFDH OBSCN CHD3 NUP214 FNBP1L PRPF8 FANCD2 CUL5 ATXN2 CEBPZ CLTC NOC4L KLHDC10 DDX24 TAF1L PRRC2B	2.75e-05	1345	108	20	int:NXF1
Interaction	RPS16 interactions	GTPBP4 HBS1L CHD3 FNBP1L RRBP1 PRPF8 FANCD2 CUL5 MICALL2 ATXN2 XRN1 NOC4L DDX24 PRRC2B	3.24e-05	724	108	14	int:RPS16
Interaction	XRN2 interactions	GTPBP4 DSCAM WDR33 CHD3 ARHGAP39 FANCD2 CEBPZ XRN1 USP7 NOC4L	3.87e-05	381	108	10	int:XRN2
Interaction	ASB15 interactions	PRPF8 CUL5 SVIL DLD	4.50e-05	37	108	4	int:ASB15
Interaction	HNRNPA2B1 interactions	SF3A1 CUL9 CHD3 RRBP1 PRPF8 FANCD2 CUL5 MICALL2 ATXN2 CLTC XRN1 DLD DDX24 DYNC1LI2	5.03e-05	754	108	14	int:HNRNPA2B1
Interaction	CFAP91 interactions	DSCAM PRKAB1 USP7	5.22e-05	14	108	3	int:CFAP91
Interaction	RPLP0 interactions	GTPBP4 RANBP2 CENPL CHD3 PRPF8 FANCD2 CUL5 MICALL2 ATXN2 CEBPZ XRN1 USP7 DDX24	5.25e-05	660	108	13	int:RPLP0
Interaction	ACTN4 interactions	DSCAM ACTN1 PRPF8 FANCD2 MICALL2 ATXN2 SVIL CLTC DLD DDX24	5.83e-05	400	108	10	int:ACTN4
Interaction	H2BC26 interactions	GON4L SRCAP FANCD2 MICALL2 CEBPZ USP7 MAP4K4	5.85e-05	183	108	7	int:H2BC26
Interaction	KCNA3 interactions	HBS1L RANBP2 SF3A1 MINK1 ARHGEF12 NUP214 ARHGAP39 RRBP1 CCNK ESYT2 XRN1 PDS5A MAP4K4 EIF2AK3 GOLGB1	6.25e-05	871	108	15	int:KCNA3
Interaction	POLR1G interactions	DPF1 GTPBP4 POLR2C GPX4 SRCAP CEBPZ CLTC USP7 DLD PDS5A DDX24	6.36e-05	489	108	11	int:POLR1G
Interaction	H2BC3 interactions	RANBP2 WDR33 GON4L CHD3 RRBP1 SRCAP FANCD2 USP7 PDS5A DDX24	6.60e-05	406	108	10	int:H2BC3
Interaction	ELOB interactions	ARHGAP39 PRPF8 ASB12 FANCD2 CUL5 CTPS2 KLHDC10 SPSB2 DYNC1LI2	6.68e-05	327	108	9	int:ELOB
Interaction	SPTAN1 interactions	NUCB2 ACTN1 EPB41L4A FANCD2 CCDC112 PTP4A2 CTPS2 SVIL CLTC USP7 DDX24	7.22e-05	496	108	11	int:SPTAN1
Interaction	PES1 interactions	GTPBP4 CGAS RRBP1 FANCD2 CEBPZ USP7 NOC4L DDX24	7.56e-05	258	108	8	int:PES1
Interaction	PHLPP1 interactions	RANBP2 CHD3 NUP214 RRBP1 PRPF8 CLTC XRN1 DLD GOLGB1	7.68e-05	333	108	9	int:PHLPP1
Interaction	RPL13A interactions	GTPBP4 KBTBD6 CHD3 PRPF8 FANCD2 CUL5 MICALL2 ATXN2 CEBPZ XRN1 DDX24 PRRC2B	7.78e-05	591	108	12	int:RPL13A
Interaction	EFTUD2 interactions	GTPBP4 HBS1L RANBP2 SF3A1 POLR2C CUL9 CHD3 FNBP1L RRBP1 PRPF8 FANCD2 CUL5 CTPS2 CEBPZ CHTF18 CLTC USP7 PDS5A DDX24 GOLGB1	7.81e-05	1449	108	20	int:EFTUD2
Interaction	DHX15 interactions	RANBP2 SF3A1 POLR2C CHD3 PRPF8 FANCD2 CUL5 PTP4A2 CTPS2 ATXN2 USP7	8.04e-05	502	108	11	int:DHX15
Interaction	STIP1 interactions	GTPBP4 RANBP2 POLR2C GPX4 NUP214 ACTN1 ARHGAP39 PRPF8 FANCD2 ESYT2 ATXN2 CLTC USP7 DLD NOC4L PDS5A	8.91e-05	1006	108	16	int:STIP1
Interaction	MAPRE1 interactions	GTPBP4 RANBP2 CGAS NUP214 ACTN1 RRBP1 TTBK2 SVIL CLTC PRRC2B DYNC1LI2	9.91e-05	514	108	11	int:MAPRE1
Interaction	PEPD interactions	LDHAL6B CUL5 CLTC USP7 DLD	9.93e-05	86	108	5	int:PEPD
Interaction	HSF1 interactions	GTPBP4 RANBP2 DPYSL3 LDHAL6B CHD3 PRPF8 CTPS2 ATXN2 CLTC USP7 GOLGB1 PRRC2B	1.03e-04	609	108	12	int:HSF1
Interaction	DCD interactions	CHD3 PRPF8 FANCD2 MICALL2 USP7 DLD DDX24	1.09e-04	202	108	7	int:DCD
Interaction	MCM3 interactions	CHD3 ACTN1 ARHGAP39 FANCD2 CTPS2 CLTC USP7 DLD DDX24	1.25e-04	355	108	9	int:MCM3
Interaction	RPS14 interactions	GTPBP4 RANBP2 CHD3 ACTN1 PRPF8 FANCD2 CUL5 MICALL2 CEBPZ NOC4L DDX24	1.28e-04	529	108	11	int:RPS14
Interaction	PRMT1 interactions	GTPBP4 WDR33 SPEG SF3A1 VPS8 RRBP1 PRPF8 MAP3K5 FANCD2 PTP4A2 ATXN2 CLTC USP7 SPSB2 PRRC2B	1.28e-04	929	108	15	int:PRMT1
Interaction	MX2 interactions	CGAS NUP214 ACTN1	1.36e-04	19	108	3	int:MX2
Interaction	APOBEC3G interactions	CGAS MAP3K5 CUL5	1.36e-04	19	108	3	int:APOBEC3G
Interaction	KIF20A interactions	GTPBP4 RANBP2 CLTCL1 WDR33 INPP5B MINK1 CGAS ACTN1 PRPF8 PCNX2 SVIL CLTC XRN1 MAP4K4 NEURL4 PRRC2B	1.49e-04	1052	108	16	int:KIF20A
Interaction	MECP2 interactions	DPF1 GTPBP4 RANBP2 WDR33 SF3A1 POLR2C ARHGAP39 SRCAP PRPF8 CCNK CEBPZ CLTC USP7 NOC4L PDS5A DDX24 MAP4K4 DYNC1LI2	1.59e-04	1287	108	18	int:MECP2
Interaction	SNRNP200 interactions	RANBP2 SF3A1 CUL9 CHD3 PRPF8 FANCD2 CUL5 PRKAB1 USP7 PDS5A	1.83e-04	460	108	10	int:SNRNP200
Interaction	DNAJC9 interactions	GTPBP4 MINK1 NUP214 FANCD2 CEBPZ NOC4L DDX24 MAP4K4	1.95e-04	296	108	8	int:DNAJC9
Interaction	PURG interactions	GTPBP4 ATXN2 CEBPZ XRN1 NOC4L ZNF616 DDX24	2.00e-04	223	108	7	int:PURG
Interaction	CLTC interactions	RANBP2 CLTCL1 DSCAM POLR2C ACTN1 PRPF8 FANCD2 CUL5 CTPS2 SVIL CLTC USP7	2.03e-04	655	108	12	int:CLTC
Interaction	KLHDC10 interactions	PRPF8 MICALL2 USP7 KLHDC10	2.16e-04	55	108	4	int:KLHDC10
Interaction	NAA40 interactions	GTPBP4 RANBP2 DPYSL3 SF3A1 CHD3 NUP214 RRBP1 SRCAP PRPF8 CCNK XRN1 USP7 DLD GOLGB1 PRRC2B	2.24e-04	978	108	15	int:NAA40
Interaction	RPL30 interactions	GTPBP4 MINK1 CHD3 PRPF8 FANCD2 CEBPZ XRN1 DLD DDX24 MAP4K4	2.33e-04	474	108	10	int:RPL30
Interaction	DDX39B interactions	GTPBP4 SF3A1 CHD3 ACTN1 PRPF8 FANCD2 GVINP1 SVIL CLTC DLD DYNC1LI2	2.44e-04	570	108	11	int:DDX39B
Interaction	DDX23 interactions	GTPBP4 SF3A1 CHD3 PRPF8 CCNK FANCD2 CEBPZ DLD PDS5A DDX24	2.58e-04	480	108	10	int:DDX23
Interaction	RAC2 interactions	MINK1 ARHGAP39 RRBP1 FANCD2 ESYT2 VPS13D CLTC USP7 MAP4K4 EIF2AK3 GOLGB1 SEC14L2	2.64e-04	674	108	12	int:RAC2
Interaction	POLR1C interactions	GTPBP4 POLR2C CCNK FANCD2 CTPS2 DLD DDX24 DYNC1LI2	2.72e-04	311	108	8	int:POLR1C
Interaction	ANKFY1 interactions	VPS8 CGAS ARHGEF12 ARHGAP39 LAP3 FANCD2 MAP4K4	2.83e-04	236	108	7	int:ANKFY1
Interaction	PLS3 interactions	RRBP1 PRPF8 FANCD2 CUL5 ATXN2 USP7 DLD	2.90e-04	237	108	7	int:PLS3
Interaction	DCTPP1 interactions	FANCD2 CUL5 USP7 DLD	3.02e-04	60	108	4	int:DCTPP1
Interaction	RPL10A interactions	GTPBP4 CHD3 RRBP1 PRPF8 FANCD2 CUL5 MICALL2 XRN1 DLD DDX24	3.04e-04	490	108	10	int:RPL10A
Interaction	GAPDH interactions	RANBP2 OBSCN CHD3 PRPF8 MAP3K5 FANCD2 MICALL2 ATXN2 SVIL CLTC TMC5 DDX24	3.10e-04	686	108	12	int:GAPDH
Interaction	DSCAM interactions	DSCAM CUL9 ACTN1 PRPF8 CLTC MAP4K4	3.20e-04	171	108	6	int:DSCAM
Interaction	ILF2 interactions	GTPBP4 RANBP2 CHD3 PRPF8 FANCD2 CUL5 MICALL2 ATXN2 CEBPZ DLD EIF2AK3	3.27e-04	590	108	11	int:ILF2
Interaction	RAB9A interactions	GTPBP4 INPP5B VPS8 RRBP1 ATP13A2 FANCD2 ESYT2 VPS13D USP7 EIF2AK3 GOLGB1	3.51e-04	595	108	11	int:RAB9A
Interaction	CDKL5 interactions	RANBP2 MINK1 ARHGAP39 XRN1 USP7	3.57e-04	113	108	5	int:CDKL5
Interaction	EBNA1BP2 interactions	GTPBP4 MINK1 CHD3 PRPF8 FANCD2 CEBPZ XRN1 DDX24	3.58e-04	324	108	8	int:EBNA1BP2
Interaction	USP36 interactions	GTPBP4 RANBP2 CHD3 RRBP1 PRPF8 FANCD2 CEBPZ CLTC USP7 NOC4L DDX24	3.71e-04	599	108	11	int:USP36
Interaction	RPL36 interactions	GTPBP4 MINK1 OBSCN CHD3 PRPF8 FANCD2 CEBPZ ZNF616 DDX24 MAP4K4	3.79e-04	504	108	10	int:RPL36
Interaction	H2AC4 interactions	GON4L CHD3 BRMS1L FANCD2 CUL5 MICALL2 SVIL USP7 DLD DDX24	3.91e-04	506	108	10	int:H2AC4
Interaction	NOP2 interactions	GTPBP4 MINK1 CHD3 PRPF8 FANCD2 CEBPZ USP7 DDX24 MAP4K4	4.03e-04	416	108	9	int:NOP2
Interaction	TMPRSS11B interactions	RRM2B RRBP1 FANCD2 ESYT2 CLTC PDS5A EIF2AK3 GOLGB1 DYNC1LI2	4.03e-04	416	108	9	int:TMPRSS11B
Interaction	RPL5 interactions	GTPBP4 CHD3 RRBP1 PRPF8 FANCD2 CUL5 MICALL2 ATXN2 XRN1 DDX24 MAP4K4	4.09e-04	606	108	11	int:RPL5
Interaction	IGLC3 interactions	PRPF8 FANCD2	4.21e-04	6	108	2	int:IGLC3
Interaction	JAKMIP3 interactions	STMND1 USP7	4.21e-04	6	108	2	int:JAKMIP3
Interaction	PIP interactions	RANBP2 CHD3 ARHGAP39 FANCD2 USP7 DDX24	4.33e-04	181	108	6	int:PIP
Interaction	FGF3 interactions	GTPBP4 POLR2C CEBPZ XRN1	4.35e-04	66	108	4	int:FGF3
Interaction	GIPC1 interactions	ARHGEF12 ACTN1 FNBP1L KLHL9 FHIP1A	4.53e-04	119	108	5	int:GIPC1
Interaction	ALG13 interactions	WDR33 CUL9 CCNK ATXN2 XRN1 PRRC2B	4.59e-04	183	108	6	int:ALG13
Interaction	RAC3 interactions	MINK1 CGAS ARHGEF12 ARHGAP39 FNBP1L RRBP1 ESYT2 CLTC MAP4K4 EIF2AK3 GOLGB1	4.89e-04	619	108	11	int:RAC3
Interaction	FZR1 interactions	GTPBP4 SPEG SF3A1 RRM2B ARHGEF12 RRBP1 PRPF8 CCNK MAP3K5 FANCD2 ATXN2 CEBPZ USP7 NOC4L PDS5A DDX24	5.00e-04	1172	108	16	int:FZR1
Interaction	APOBEC3C interactions	CLTCL1 KBTBD6 CGAS CHD3 CUL5 CTPS2	5.15e-04	187	108	6	int:APOBEC3C
Interaction	HNRNPA1 interactions	WDR33 SF3A1 ARHGEF12 CHD3 PRPF8 CCNK FANCD2 CUL5 ATXN2 CLTC XRN1 ALPK3 DDX24 PRRC2B	5.21e-04	945	108	14	int:HNRNPA1
Interaction	G3BP1 interactions	GTPBP4 RANBP2 DPYSL3 GPX4 CHD3 NUP214 PRPF8 FANCD2 MICALL2 ATXN2 DLD MAP4K4 PRRC2B	5.26e-04	835	108	13	int:G3BP1
Interaction	LGR4 interactions	RANBP2 CLTCL1 DSCAM CHD3 RRBP1 PRPF8 CLTC	5.29e-04	262	108	7	int:LGR4
Interaction	MTREX interactions	HBS1L SF3A1 CHD3 PRPF8 FANCD2 XRN1 USP7	5.29e-04	262	108	7	int:MTREX
Interaction	SMARCA1 interactions	CGAS CHD3 BRMS1L FANCD2 USP7 MAP4K4	5.30e-04	188	108	6	int:SMARCA1
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	DSCAM SPEG OBSCN HMCN1 ALPK3 CNTN2	2.43e-05	161	65	6	593
GeneFamily	Cullins	CUL9 CUL5	3.51e-04	8	65	2	1032
GeneFamily	Acyl-CoA thioesterases	ACOT6 ACOT4	5.62e-04	10	65	2	41
ToppCell	RV-15._Ventricular_Cardiomyocyte_III\|World / Chamber and Cluster_Paper	OBSCN ARHGEF12 RASGRP3 SVIL ALPK3 EIF2AK3 FHIP1A	4.29e-07	189	109	7	0a82931b5f6c0a6427ca3edd5e2235ac49099d40
ToppCell	RV-15._Ventricular_Cardiomyocyte_III\|RV / Chamber and Cluster_Paper	OBSCN ARHGEF12 RASGRP3 SVIL ALPK3 EIF2AK3 FHIP1A	4.44e-07	190	109	7	93c3188dfeb0b2f9889f8ae9b9c1f2f34129c99b
ToppCell	PND10\|World / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DPYSL3 ARHGEF12 RRBP1 PTP4A2 HMCN1 MAP4K4 GOLGB1	4.44e-07	190	109	7	d67e2814047c8df2ae4b7bc8be9539f5df6ecef2
ToppCell	facs-Lung-nan-3m-Endothelial-endothelial_cell_of_lung\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGEF12 FNBP1L ATP13A2 DENND3 RASIP1 HMCN1 RASGRP3	5.11e-07	194	109	7	f159ef8541d75a4e98468947f231bb463bec922c
ToppCell	-Hematopoietic_Mast\| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	HBS1L GPX4 PRPF8 PTP4A2	1.11e-06	32	109	4	ca3d87cac849c1b713acd984626f214f5c8e1433
ToppCell	-Hematopoietic_Mast-Mast_cells-Mast-cells\| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	HBS1L GPX4 PRPF8 PTP4A2	1.11e-06	32	109	4	c6b707107c661f81e5afa945dd62b37a73bfadf9
ToppCell	-Hematopoietic_Mast-Mast_cells\| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	HBS1L GPX4 PRPF8 PTP4A2	1.11e-06	32	109	4	de636b6fbdc9368ef6ce7157acbf84e28330cd94
ToppCell	(7)_MNP-(7)_DC_plasmacytoid\|(7)_MNP / Spleen cell shreds - cell class (v1) and cell subclass (v1)	NUCB2 RRBP1 ATP13A2 KCNK10 SEL1L3 PROC	6.35e-06	185	109	6	9f67f652488e17075a372e2a2e1100f6d0af6d7d
ToppCell	COVID-19_Severe-pDC\|World / disease group, cell group and cell class	NUCB2 RRBP1 ATP13A2 KCNK10 SEL1L3 PROC	6.96e-06	188	109	6	4c8e328b8206120708b05ea3c5865a0200dc5c4e
ToppCell	3'_v3-bone_marrow-Myeloid_Dendritic-pDC\|bone_marrow / Manually curated celltypes from each tissue	RRBP1 ATP13A2 KCNK10 SEL1L3 FHIP1A PROC	7.40e-06	190	109	6	dde0e34f6a06cdbbb65c86472360c09f0279a572
ToppCell	Smart-seq2-bone_marrow_(Smart-seq2)-myeloid-myeloid_granulocytic-neutrophil\|bone_marrow_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	CLTCL1 KBTBD6 ACTN1 DENND3 ENTPD1 MAP4K4	7.62e-06	191	109	6	d4f77c73311d1149466bbfe4adbd6a301946ec90
ToppCell	facs-Lung-nan-3m-Endothelial-Capillary_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGEF12 DENND3 RASIP1 HMCN1 RASGRP3 ENTPD1	7.85e-06	192	109	6	4bab9754cfd8b9c2d7cc1490e8a29f58c3c26f6c
ToppCell	Healthy-pDC\|Healthy / disease group, cell group and cell class	RRBP1 ATP13A2 KCNK10 SEL1L3 FHIP1A PROC	7.85e-06	192	109	6	33d695a28d22b4af111df9591830a33bb7ef7b2d
ToppCell	Smart-seq2-bone_marrow_(Smart-seq2)-myeloid-myeloid_granulocytic\|bone_marrow_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	CLTCL1 KBTBD6 ACTN1 DENND3 ENTPD1 MAP4K4	8.09e-06	193	109	6	e1855cff9a6bcfda9188b9fdf6c9d698405da990
ToppCell	LV-10._Endothelium_II\|LV / Chamber and Cluster_Paper	ACTN1 EPB41L4A RASIP1 HMCN1 ENTPD1 RASGEF1B	8.33e-06	194	109	6	b6cc849fa08599bff9839ef382d190cc964e273e
ToppCell	Smart-seq2-lymph_node_(Smart-seq2)-lymphocytic-B_lymphocytic\|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	DRAM2 DENND3 RASGRP3 ENTPD1 SEL1L3 EIF2AK3	9.09e-06	197	109	6	fa3cc33c975648172feabb485c3bdd087f1f8ea7
ToppCell	COVID_non-vent-Lymphocytic-Plasma_cell-IgA_Plasmablast\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	NUCB2 RRBP1 RASGRP3 ENTPD1 SEL1L3 EIF2AK3	9.09e-06	197	109	6	fdbf4eb9fa5aefb4ffb307494fe4774bf5e0aaeb
ToppCell	LPS_IL1RA\|World / Treatment groups by lineage, cell group, cell type	ARHGEF12 RRBP1 LAP3 PTP4A2 SVIL MAP4K4	9.91e-06	200	109	6	a02fa5b3c4723a6eaa3c685588666c710478dd25
ToppCell	ILEUM-non-inflamed-(3)_pDC\|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	DPF1 ATP13A2 KCNK10 FHIP1A PROC	5.06e-05	163	109	5	bc5411702badab39143905aa51676b4bbfad2041
ToppCell	severe_influenza-pDC\|World / disease group, cell group and cell class (v2)	ATP13A2 LDHC KCNK10 FHIP1A PROC	6.18e-05	170	109	5	b9c08af83241666bbdbed9109cadcd088c0f647d
ToppCell	367C-Myeloid-Dendritic-pDC\|Dendritic / Donor, Lineage, Cell class and subclass (all cells)	ATP13A2 KCNK10 SEL1L3 FHIP1A PROC	6.18e-05	170	109	5	fbb7019c6fba87326702b51f6819ea1af5f3a9b7
ToppCell	mild_COVID-19-pDC\|World / disease group, cell group and cell class (v2)	HMCN1 KCNK10 SEL1L3 FHIP1A PROC	6.53e-05	172	109	5	dab2f1a05c7df58d9387b13271b3f1f1583f9ac3
ToppCell	10x5'-blood-Myeloid_Dendritic\|blood / Manually curated celltypes from each tissue	DPYSL3 LAP3 KCNK10 FHIP1A PROC	7.08e-05	175	109	5	1c48eec300d5a6d4a810947b995af3b8c0a5a601
ToppCell	IIF-Myeloid-pDC\|IIF / Disease, Lineage and Cell Type	RRBP1 KCNK10 SEL1L3 FHIP1A PROC	7.08e-05	175	109	5	35cfb7d0b88678ff5b83ad6e19dbc15a908a3fcc
ToppCell	nucseq-Immune-Immune_Myeloid-Myeloid_Dendritic-pDC\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	RRBP1 KCNK10 SEL1L3 FHIP1A PROC	7.08e-05	175	109	5	37c2d4e0b6e9a3171931797ce9a54f3347288e57
ToppCell	10x_3'_v3-tissue-resident_(10x_3'_v3)-myeloid-myeloid_dendritic-plasmacytoid_dendritic_cell\|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	ATP13A2 KCNK10 SEL1L3 FHIP1A PROC	7.08e-05	175	109	5	97fe431f224b592b3076632d101e19136c138dcc
ToppCell	B_cells-pDCs\|B_cells / Immune cells in Kidney/Urine in Lupus Nephritis	FNBP1L ATP13A2 KCNK10 FHIP1A PROC	7.28e-05	176	109	5	ce757de9e09a225f3f96433f103f43619b0e0dda
ToppCell	COPD-Myeloid-pDC\|COPD / Disease state, Lineage and Cell class	RRBP1 KCNK10 SEL1L3 FHIP1A PROC	7.47e-05	177	109	5	415aa023195a7f961c09529f65cdcc7bb90eaf5d
ToppCell	PND28-Immune-Immune_Myeloid-Megakaryocyte/Platelet\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	VPS8 ETFDH GPX4 EPB41L4A SPSB2	7.88e-05	179	109	5	362c003503190dc272fa89185a83a65e063d7a67
ToppCell	PND28-Immune-Immune_Myeloid-Megakaryocyte/Platelet-Megakaryocyte/Platelet\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	VPS8 ETFDH GPX4 EPB41L4A SPSB2	7.88e-05	179	109	5	e0eec8d48868c76c3e879f219357c62ceff1bc76
ToppCell	PND28-Immune-Immune_Myeloid-Megakaryocyte/Platelet-Megakaryocyte/Platelet-Megakaryocyte/Platelet_mature\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	VPS8 ETFDH GPX4 EPB41L4A SPSB2	7.88e-05	179	109	5	7d2e6bde00a9ab4cb21bd48b140ce205e36f9d77
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Endothelial-blood_vessel_EC-venous_capillary\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DENND3 RASIP1 RASGRP3 ENTPD1 ALPK3	8.09e-05	180	109	5	97e0dcb7cfbba60a782824c5e23995058609fcd4
ToppCell	3'_v3-Lung-Myeloid_Dendritic-pDC\|Lung / Manually curated celltypes from each tissue	ATP13A2 KCNK10 SEL1L3 FHIP1A PROC	8.30e-05	181	109	5	3d7f089fb434fbc989f1fa159e22133ae00b2487
ToppCell	tumor_Lung-Myeloid_cells-pDCs\|tumor_Lung / Location, Cell class and cell subclass	ATP13A2 KCNK10 SEL1L3 FHIP1A PROC	8.30e-05	181	109	5	c864ffeb9234b8c29754afc91c85a972889617f4
ToppCell	5'-Adult-SmallIntestine-Hematopoietic-Plasma_cells-IgA_plasma_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NUCB2 DENND3 RASGRP3 SEL1L3 EIF2AK3	8.52e-05	182	109	5	626aabfd9ac662c1d189f7c4b660482914d9e669
ToppCell	5'-Adult-SmallIntestine-Hematopoietic-Plasma_cells\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NUCB2 DENND3 RASGRP3 SEL1L3 EIF2AK3	8.52e-05	182	109	5	a00abff41c12b71d5860c494b8c722d649fd5f36
ToppCell	368C-Lymphocytic-Plasma_cell\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	NUCB2 RRBP1 RASGRP3 ENTPD1 SEL1L3	8.75e-05	183	109	5	7733cf919eda146efe41c93990658ce92db73aa8
ToppCell	normal_Lung-B_lymphocytes-GrB-secreting_B_cells\|normal_Lung / Location, Cell class and cell subclass	ATP13A2 KCNK10 SEL1L3 FHIP1A PROC	8.75e-05	183	109	5	c930b957d16f9b0904b6c424acd914532e5cc137
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Myeloid-Dendritic-plasmacytoid_dendritic_cell-DC_c4-LILRA4\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	ATP13A2 KCNK10 SEL1L3 FHIP1A PROC	8.75e-05	183	109	5	3b123571e10c132227aff65648b4b3c6acb4bd00
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Myeloid-Dendritic-plasmacytoid_dendritic_cell\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	ATP13A2 KCNK10 SEL1L3 FHIP1A PROC	8.75e-05	183	109	5	df6fd0927b6e4cf9a1583969a68096e4bccfbace
ToppCell	368C-Lymphocytic-Plasma_cell-\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	NUCB2 RRBP1 RASGRP3 ENTPD1 SEL1L3	8.75e-05	183	109	5	d91441cbf94f5c3b7c36f2ca3a46895870bd730f
ToppCell	myeloid-Dendritic_cell-Plasmacytoid_dendritic_cell\|World / Lineage, cell class and subclass	RRBP1 ATP13A2 KCNK10 SEL1L3 PROC	8.97e-05	184	109	5	11619778bc773ecd1a9867330be04deaf324f31e
ToppCell	10x5'-bone_marrow-Myeloid_Dendritic-pDC\|bone_marrow / Manually curated celltypes from each tissue	ATP13A2 KCNK10 SEL1L3 FHIP1A PROC	8.97e-05	184	109	5	2817d530863e85dfdcd143b7a3dc5fc58a9cd98b
ToppCell	ILEUM-inflamed-(3)_MNP-(3)_pDC\|(3)_MNP / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	NUCB2 RRBP1 ATP13A2 SEL1L3 PROC	9.20e-05	185	109	5	308a98f111895071d8772bc010554471cc12fab2
ToppCell	tumor_Lung-Myeloid_cells-pDCs\|Myeloid_cells / Location, Cell class and cell subclass	ATP13A2 KCNK10 SEL1L3 FHIP1A PROC	9.44e-05	186	109	5	3d7c1a281fb82db4471283f39937007d889a5f38
ToppCell	droplet-Bladder-nan\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RANBP2 CHD3 CEBPZ DDX24 GOLGB1	9.68e-05	187	109	5	663991a8afe652e92363b64bcbd68c14d0307f0e
ToppCell	(0)_Myeloid-(01)_Dendritic_cell-(011)_pDC\|(01)_Dendritic_cell / immune cells in Peripheral Blood (logTPM normalization)	NUCB2 ATP13A2 KCNK10 SEL1L3 PROC	9.68e-05	187	109	5	068502efa3f0ac4cea2fa4a18d1c2f686a4fba54
ToppCell	Control-Lymphoid-B\|Lymphoid / Disease state, Lineage and Cell class	DRAM2 RASGRP3 SEL1L3 MAP4K4 EIF2AK3	9.68e-05	187	109	5	4e64be635f445276e71f2937f33f041c3a4204ab
ToppCell	systemic_lupus_erythematosus-flare-Myeloid-plasmacytoid_dendritic_cell-male\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	INPP5B ATP13A2 KCNK10 SEL1L3 PROC	9.68e-05	187	109	5	d3563bb087e476baea5b59389e4d34d0ff98cac5
ToppCell	IPF-Lymphoid-B\|Lymphoid / Disease state, Lineage and Cell class	DRAM2 RASGRP3 SEL1L3 MAP4K4 EIF2AK3	9.68e-05	187	109	5	af1327559f7e01bec070881cae52834917c3da65
ToppCell	COVID-19_Severe-pDC-\|COVID-19_Severe / Disease condition and Cell class	NUCB2 ATP13A2 KCNK10 SEL1L3 PROC	9.93e-05	188	109	5	9fd1116e31a05554850b8ed3c005ea660dfbd51c
ToppCell	390C-Lymphocytic-CD4_T-cell-Treg_cell_1\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	KBTBD6 MINK1 ARHGEF12 VPS13D CHTF18	9.93e-05	188	109	5	2c4e791df69a9df29922f9117e5cac7787c129ce
ToppCell	COVID-19_Mild-pDC\|COVID-19_Mild / Disease condition and Cell class	NUCB2 KCNK10 SEL1L3 FHIP1A PROC	9.93e-05	188	109	5	62d33d2990d4a2d32bd0863147e47f656df1966e
ToppCell	390C-Lymphocytic-CD4_T-cell-Treg_cell_1\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	KBTBD6 MINK1 ARHGEF12 VPS13D CHTF18	9.93e-05	188	109	5	b1ec7c45aedcc3d22cac898c6a3679e7f8b44c77
ToppCell	myeloid-pDC\|myeloid / Lineage and Cell class	NUCB2 ATP13A2 KCNK10 SEL1L3 PROC	9.93e-05	188	109	5	a2dc4bbeca2bdc00c51825dd65a699c54c72f241
ToppCell	COVID-19_Mild-pDC-\|COVID-19_Mild / Disease condition and Cell class	NUCB2 KCNK10 SEL1L3 FHIP1A PROC	9.93e-05	188	109	5	a75c2cf2f8dae343c13aaa66b637658b935ed10a
ToppCell	COVID-19_Severe-pDC\|COVID-19_Severe / Disease condition and Cell class	NUCB2 ATP13A2 KCNK10 SEL1L3 PROC	9.93e-05	188	109	5	475008f45673b42b75ef231c2df91f8b9adc9201
ToppCell	IPF-Lymphoid-T_Regulatory\|Lymphoid / Disease state, Lineage and Cell class	HBS1L ARHGEF12 CUL9 MAP3K5 ENTPD1	1.02e-04	189	109	5	7a260485c2a7c743c14d048e5e480ae0a9b8e32c
ToppCell	Int-URO-Myeloid-pDC\|Int-URO / Disease, Lineage and Cell Type	NUCB2 ATP13A2 KCNK10 SEL1L3 PROC	1.02e-04	189	109	5	37aee7a0acd5fd5dd62f22608d72ff8afe210e5c
ToppCell	droplet-Lung-LUNG-30m-Endothelial\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGEF12 FNBP1L RASIP1 HMCN1 RASGRP3	1.02e-04	189	109	5	25db316f66cee53774bb2b286cc457b37353356c
ToppCell	Control-Myeloid-pDC\|Control / Disease group, lineage and cell class	ATP13A2 KCNK10 SEL1L3 FHIP1A PROC	1.02e-04	189	109	5	46770b99da42f11f10cfc67cea8562342d60b867
ToppCell	PBMC-Control-Myeloid-pDC\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	ATP13A2 KCNK10 SEL1L3 FHIP1A PROC	1.04e-04	190	109	5	adffa93635da10251f28b2089fd96b189775c8b4
ToppCell	PBMC-Control-Myeloid-pDC-pDC\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ATP13A2 KCNK10 SEL1L3 FHIP1A PROC	1.04e-04	190	109	5	9a91bf1ea105029e6412d0d9060bca325299ce26
ToppCell	PBMC-Control-Myeloid-pDC-pDC\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	ATP13A2 KCNK10 SEL1L3 FHIP1A PROC	1.04e-04	190	109	5	39c8ddc2639bf3e986dae11fbae61a735614b604
ToppCell	COVID-19-Heart-CM_4\|Heart / Disease (COVID-19 only), tissue and cell type	PTP4A2 RASGRP3 ALPK3 EIF2AK3 FHIP1A	1.04e-04	190	109	5	3729648a17093b438398b82e32bbccc3af7b8c5d
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DPYSL3 SPEG ACTN1 HMCN1 SVIL	1.04e-04	190	109	5	562ee3b025c29edf07b8b344323edb49d82f1c7e
ToppCell	PBMC-Control-Myeloid-pDC\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ATP13A2 KCNK10 SEL1L3 FHIP1A PROC	1.04e-04	190	109	5	2c1c079fd411c03bc3f383aa927eea9446716960
ToppCell	myeloid-pDC\|World / Lineage and Cell class	RRBP1 KCNK10 SEL1L3 FHIP1A PROC	1.04e-04	190	109	5	88c42779ce2f817d28e672d83f3f1158581edf73
ToppCell	3'_v3-bone_marrow-Myeloid_Dendritic\|bone_marrow / Manually curated celltypes from each tissue	ATP13A2 KCNK10 SEL1L3 FHIP1A PROC	1.04e-04	190	109	5	6892c603037b61ef88d6ca01b7592dc0d347d63b
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DPYSL3 SPEG ACTN1 HMCN1 SVIL	1.04e-04	190	109	5	f5fb989afabb49d64d91324570cd8c80a4b9e67d
ToppCell	droplet-Lung-LUNG-30m-Endothelial-endothelial_cell_of_lung\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGEF12 FNBP1L RASIP1 HMCN1 RASGRP3	1.04e-04	190	109	5	e64b191f928935484e2c993d7f8af0572a617a3a
ToppCell	PBMC-Control-Myeloid-pDC-pDC-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ATP13A2 KCNK10 SEL1L3 FHIP1A PROC	1.04e-04	190	109	5	a95aea3aa707fc4574810706341a5f32b3d00209
ToppCell	PBMC-Control-Myeloid-pDC-pDC-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	ATP13A2 KCNK10 SEL1L3 FHIP1A PROC	1.04e-04	190	109	5	18dfa84c62dcf081ce9958a71e76a394ec0968e4
ToppCell	COPD-Lymphoid-B\|Lymphoid / Disease state, Lineage and Cell class	RASGRP3 RASGEF1B SEL1L3 MAP4K4 EIF2AK3	1.04e-04	190	109	5	1e85ee686ff6dd27c69415d524d54fa825b1daad
ToppCell	PBMC-Severe-Lymphocyte-B-Plasmablast-Plasmablast-Plasmablast\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	RRBP1 RASGRP3 ENTPD1 SEL1L3 EIF2AK3	1.04e-04	190	109	5	84eb7761f537d270673909a71d4f122e826769d5
ToppCell	COVID-19_Moderate-pDC\|World / disease group, cell group and cell class	ATP13A2 KCNK10 SEL1L3 FHIP1A PROC	1.07e-04	191	109	5	93adfbc0b22f6006d6d5ad67a99e33cbe9e1dfe9
ToppCell	Control-pDC\|Control / Disease condition and Cell class	NUCB2 ATP13A2 KCNK10 SEL1L3 PROC	1.07e-04	191	109	5	543e1437a52d04436862dd1c27b4fae95c44fcc8
ToppCell	systemic_lupus_erythematosus-managed-Myeloid-plasmacytoid_dendritic_cell-female\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	RRBP1 ATP13A2 KCNK10 FHIP1A PROC	1.07e-04	191	109	5	78d523f562d32fc408a20d99b0c61cc103241bc0
ToppCell	Control-pDC-\|Control / Disease condition and Cell class	NUCB2 ATP13A2 KCNK10 SEL1L3 PROC	1.07e-04	191	109	5	1d7b0fae4d114d6db933c18b4eb2066ffa61356d
ToppCell	Healthy-pDC\|World / disease group, cell group and cell class	ATP13A2 KCNK10 SEL1L3 FHIP1A PROC	1.07e-04	191	109	5	6e1d825dc33b915b95f13ccd237a552160a4be98
ToppCell	COVID-19-Heart-EC_(POSTN)\|Heart / Disease (COVID-19 only), tissue and cell type	ACTN1 EPB41L4A HMCN1 ENTPD1 RASGEF1B	1.10e-04	192	109	5	c0c34785a7bdf461722029b322e9184e3d9b3c26
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Endothelial-Endothelial_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FNBP1L DENND3 RASIP1 ESYT2 HMCN1	1.10e-04	192	109	5	9d53b42cdb537b30233cdfdc08052c8b13a1113f
ToppCell	LPS_only-Endothelial-Endothelial-Vein\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ACTN1 EPB41L4A RASIP1 HMCN1 ENTPD1	1.10e-04	192	109	5	52acaecd3703166f5ce3b328aff7c82bd142fee4
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Endothelial-endothelial_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FNBP1L DENND3 RASIP1 ESYT2 HMCN1	1.10e-04	192	109	5	042391162df2e3d0027688dd14163c4c6821afe0
ToppCell	LPS-antiTNF-Endothelial-Endothelial-Vein\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ACTN1 EPB41L4A RASIP1 HMCN1 ENTPD1	1.10e-04	192	109	5	81baf1c4063469bb0c03a8602b40e387ba7b0dfb
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Endothelial\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FNBP1L DENND3 RASIP1 ESYT2 HMCN1	1.10e-04	192	109	5	71b0bfee0461ff64cef35881db3959c517e9731b
ToppCell	(1)_Control_(PBS)-(1)_VE-Cad+_vascular_cells\|(1)_Control_(PBS) / Stress and Cell class	FNBP1L RASIP1 HMCN1 SVIL CLTC	1.10e-04	192	109	5	e16e49b302019474232ef4cc0ff217d33afe34cf
ToppCell	LPS-IL1RA-Endothelial-Endothelial-Vein\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ACTN1 EPB41L4A RASIP1 HMCN1 ENTPD1	1.10e-04	192	109	5	717f3d3bbee4d0f64ba1341ee2b00a407ba1e0f3
ToppCell	Epithelial-club_cell\|World / Lineage, Cell type, age group and donor	FNBP1L EPB41L4A SEL1L3 TMC5 FHIP1A	1.12e-04	193	109	5	2bdd09004fa433550958ec42ba4b06271a4aaf7c
ToppCell	facs-Lung-18m-Endothelial-capillary_endothelial\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ARHGEF12 FNBP1L RASIP1 HMCN1 RASGRP3	1.12e-04	193	109	5	ee4b31d9c92f8fd0d3ddb5e723b82300fcb459d1
ToppCell	control-pDC\|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	RRBP1 ATP13A2 SEL1L3 FHIP1A PROC	1.12e-04	193	109	5	30a6559c9a9e8941861cb259b4836acccc427e68
ToppCell	LPS-IL1RA+antiTNF-Endothelial-Endothelial-Vein\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DPYSL3 ACTN1 RASIP1 HMCN1 ENTPD1	1.12e-04	193	109	5	7261c1ce30c796b61c6ec58e64a051baa24732ff
ToppCell	facs-Lung-18m-Endothelial-capillary_endothelial-capillary_endothelial_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ARHGEF12 FNBP1L RASIP1 HMCN1 RASGRP3	1.12e-04	193	109	5	7401e276b644b254c692160d0e7417ec28d50aa4
ToppCell	Smart-seq2-lymph_node_(Smart-seq2)-lymphocytic-B_lymphocytic-B_cell\|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	ENTPD1 RASGEF1B SEL1L3 MAP4K4 EIF2AK3	1.15e-04	194	109	5	ff661419b697aef51a53fdeac8d37d870d65f491
ToppCell	control-Lymphoid-B_cell\|Lymphoid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	DRAM2 DENND3 RASGRP3 ENTPD1 RASGEF1B	1.15e-04	194	109	5	a5284adca931a78b1c4592925c4860853ebd24f1
ToppCell	E12.5-Mesenchymal-myocytic_cell-aortic_smooth_muscle_cell\|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	ITLN1 SPEG ACTN1 SVIL ENTPD1	1.18e-04	195	109	5	bff7685784688425bebd78b0f284a6d4475a9415
ToppCell	Bronchial-10x5prime-Immune_Myeloid-Dendritic_cell-DC_plasmacytoid\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	ATP13A2 KCNK10 SEL1L3 FHIP1A PROC	1.18e-04	195	109	5	fbc324c3435f32b9ca269d83333faecfe940d7fe
ToppCell	E12.5-Mesenchymal-myocytic_cell\|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	ITLN1 SPEG ACTN1 SVIL ENTPD1	1.18e-04	195	109	5	aed243418cdb5df4563a7b935c1ecbd744590901
ToppCell	Severe-Plasmablast\|Severe / disease group and sub_cluster of B and Plasma cells(res = 0.5)	NUCB2 RRBP1 ENTPD1 SEL1L3 GOLGB1	1.24e-04	197	109	5	1089aa7991812378668d0f3d57f8000e6245a713
ToppCell	COVID-19_Severe-PLT_0\|COVID-19_Severe / Disease Group and Platelet Clusters	VPS8 ARHGEF12 ACTN1 SEL1L3 SEC14L2	1.24e-04	197	109	5	dbdeefa72d10f2c5f75ad5aac6f31a892d4e94a9
Drug	U-62066 [87151-85-7]; Down 200; 1uM; PC3; HT_HG-U133A	INPP5B MINK1 GON4L DENND3 MAP3K5 PCNX2 USP7 SEC14L2	4.91e-06	197	109	8	4553_DN
Drug	Aceclofenac [89796-99-6]; Down 200; 11.2uM; MCF7; HT_HG-U133A	INPP5B MINK1 SRCAP PCNX2 TTBK2 VPS13D CES3 TMC5	5.09e-06	198	109	8	2281_DN
Drug	Iopamidol [60166-93-0]; Down 200; 5.2uM; PC3; HT_HG-U133A	SPEG POLR2C CUL9 NKIRAS2 VPS13D MICALL2 PDS5A PRRC2B	5.29e-06	199	109	8	5832_DN
Drug	Paroxetine maleate [64006-44-6]; Down 200; 1uM; MCF7; HT_HG-U133A	HBS1L MINK1 ACTN1 CCNK PCNX2 VPS13D ENTPD1 USP7	5.48e-06	200	109	8	3904_DN
Drug	AC1N9ZZC	HBS1L CLTCL1 OBSCN MAP3K5 CUL5 CLTC MAP4K4	7.61e-06	149	109	7	CID004369374
Drug	AC1L19SN	CLTCL1 RRM2B MAP3K5 CLTC EIF2AK3	1.02e-05	60	109	5	CID000000687
Drug	bis-NAD	LDHAL6B LDHC DLD	1.25e-05	10	109	3	CID003081557
Drug	polyvinylpyridine-N-oxide	LDHAL6B LDHC DLD	1.71e-05	11	109	3	CID000024772
Drug	Badg	CLTCL1 CLTC	2.27e-05	2	109	2	CID000125951
Drug	monocrotaline pyrrole	LDHAL6B LDHC CLTC EIF2AK3	2.60e-05	36	109	4	CID000104764
Drug	2-oxohexanoate	LDHAL6B LDHC DLD	2.95e-05	13	109	3	CID000159664
Drug	glycerol;phosphate	RANBP2 LDHAL6B LDHC FANCD2 CNTN2	3.90e-05	79	109	5	CID000082875
Drug	Tranylcypromine hydrochloride [1986-47-6]; Down 200; 23.6uM; PC3; HT_HG-U133A	INPP5B SPEG MINK1 GON4L CHD3 KLHL9 MICALL2	3.92e-05	192	109	7	2101_DN
Drug	Methylhydantoin-5-(L) [40856-73-3]; Down 200; 35uM; MCF7; HT_HG-U133A	WDR33 INPP5B SRCAP CCNK VPS13D PIGC USP7	4.05e-05	193	109	7	3378_DN
Drug	Pivampicillin [33817-20-8]; Down 200; 8.6uM; PC3; HT_HG-U133A	HBS1L DPYSL3 INPP5B ATP13A2 DENND3 CUL5 PRRC2B	4.05e-05	193	109	7	5046_DN
Drug	DAPH; Down 200; 10uM; PC3; HG-U133A	POLR2C RRBP1 DENND3 CEBPZ SEL1L3 PDS5A KLHDC10	4.33e-05	195	109	7	578_DN
Drug	Aceclofenac [89796-99-6]; Up 200; 11.2uM; PC3; HT_HG-U133A	WDR33 NUP214 NKIRAS2 VPS13D PIGC ENTPD1 CES3	4.47e-05	196	109	7	7269_UP
Drug	Protriptyline hydrochloride [1225-55-4]; Down 200; 13.4uM; MCF7; HT_HG-U133A	INPP5B MINK1 ETFDH CUL9 SRCAP ATP13A2 VPS13D	4.47e-05	196	109	7	5438_DN
Drug	LY294002; Down 200; 10uM; PC3; HG-U133A	GTPBP4 ACTN1 RRBP1 LDHC PRKAB1 DDX24 PRRC2B	4.47e-05	196	109	7	461_DN
Drug	Riboflavine [83-88-5]; Down 200; 10.6uM; HL60; HG-U133A	RANBP2 SF3A1 ETFDH DENND3 MAP3K5 KLHDC10 DYNC1LI2	4.47e-05	196	109	7	1767_DN
Drug	CAY10397; Up 200; 10uM; PC3; HT_HG-U133A	ARHGEF12 GON4L SRCAP KLHL9 ENTPD1 USP7 NOC4L	4.47e-05	196	109	7	7071_UP
Drug	Pentylenetetrazole [54-95-5]; Up 200; 29uM; HL60; HG-U133A	HBS1L MINK1 ARHGEF12 RRBP1 SRCAP FAM13B KLHL9	4.62e-05	197	109	7	1408_UP
Drug	Acetaminophen [103-90-2]; Down 200; 26.4uM; MCF7; HT_HG-U133A	GTPBP4 WDR33 INPP5B SPEG GON4L CUL9 SRCAP	4.62e-05	197	109	7	3364_DN
Drug	rottlerin; Down 200; 10uM; MCF7; HT_HG-U133A_EA	GTPBP4 MINK1 ARHGEF12 RRBP1 MAP3K5 VPS13D PRRC2B	4.62e-05	197	109	7	825_DN
Drug	Bucladesine sodium salt [16980-89-5]; Down 200; 7.8uM; PC3; HT_HG-U133A	INPP5B POLR2C ARHGEF12 CHD3 NUP214 TTBK2 VPS13D	4.62e-05	197	109	7	5886_DN
Drug	iloprost; Up 200; 1uM; MCF7; HG-U133A	GTPBP4 MINK1 ACTN1 RRBP1 SRCAP VPS13D CES3	4.77e-05	198	109	7	488_UP
Drug	Oxprenolol hydrochloride [6452-73-9]; Down 200; 13.2uM; PC3; HT_HG-U133A	RANBP2 ARHGEF12 RRBP1 ATP13A2 VPS13D PDS5A TMC5	4.77e-05	198	109	7	5871_DN
Drug	Dihydrostreptomycin sulfate [5490-27-7]; Down 200; 2.8uM; MCF7; HT_HG-U133A	RRBP1 ATP13A2 MAP3K5 CUL5 MICALL2 GOLGB1 PRRC2B	4.77e-05	198	109	7	6228_DN
Drug	Tolazamide [1156-19-0]; Down 200; 12.8uM; MCF7; HT_HG-U133A	WDR33 POLR2C MINK1 ARHGEF12 SRCAP SVIL ENTPD1	4.77e-05	198	109	7	2842_DN
Drug	Vinpocetine [42971-09-5]; Down 200; 11.4uM; HL60; HG-U133A	ARHGEF12 CHD3 ACTN1 NKIRAS2 PTP4A2 EIF2AK3 PRRC2B	4.92e-05	199	109	7	1557_DN
Drug	Condelphine [7633-69-4]; Up 200; 8.8uM; PC3; HT_HG-U133A	DPYSL3 INPP5B MINK1 ARHGEF12 SRCAP PDS5A PROC	4.92e-05	199	109	7	6357_UP
Drug	FK-506; Up 200; 1uM; MCF7; HG-U133A	MINK1 SRCAP DENND3 VPS13D KLHL9 CES3 NOC4L	4.92e-05	199	109	7	169_UP
Drug	clozapine; Up 200; 10uM; MCF7; HG-U133A	SPEG RRBP1 NKIRAS2 CUL5 VPS13D PDS5A KLHDC10	4.92e-05	199	109	7	416_UP
Drug	1,1-dimethylbiguanide hydrochloride; Up 200; 10uM; MCF7; HG-U133A	DPP6 GON4L RRBP1 NKIRAS2 SVIL ENTPD1 NOC4L	4.92e-05	199	109	7	1_UP
Drug	tetraethylenepentamine pentahydrochloride; Up 200; 100uM; MCF7; HG-U133A	FNBP1L DENND3 PTP4A2 VPS13D KLHL9 CES3 DLD	4.92e-05	199	109	7	406_UP
Drug	Netilmicin sulfate [56931-57-2]; Up 200; 2.8uM; MCF7; HT_HG-U133A	DPF1 HBS1L DSCAM RRBP1 SRCAP MAP3K5 VPS13D	5.08e-05	200	109	7	6005_UP
Drug	Saquinavir mesylate [149845-06-7]; Up 200; 5.2uM; MCF7; HT_HG-U133A	INPP5B SF3A1 CHD3 RRBP1 SRCAP ATP13A2 KCNK10	5.08e-05	200	109	7	6246_UP
Drug	prochlorperazine dimaleate salt; Down 200; 10uM; MCF7; HT_HG-U133A	GTPBP4 GON4L CUL9 VPS13D PIGC ENTPD1 TMC5	5.08e-05	200	109	7	5212_DN
Drug	Trileucine	CLTCL1 LAP3 CLTC	5.71e-05	16	109	3	CID000082546
Drug	KU55933	CLTCL1 RRM2B FANCD2 CLTC	8.22e-05	48	109	4	CID005278396
Drug	iodoacetic acid	LDHAL6B NUP214 LDHC LAP3 DLD	8.97e-05	94	109	5	CID000005239
Drug	AC1OAR8J	CLTCL1 CLTC	1.35e-04	4	109	2	CID006834124
Drug	alpha-hydroxybutyrate	LDHAL6B LDHC LAP3 DLD	1.51e-04	56	109	4	CID000011266
Drug	triazin-1-ium	ITLN1 LDHC PTP4A2 DLD	1.73e-04	58	109	4	CID000123047
Drug	AcPyAD	LDHAL6B LDHC DLD	1.76e-04	23	109	3	CID000002010
Drug	fluoropyruvate	LDHAL6B LDHC DLD	1.76e-04	23	109	3	CID000067946
Drug	thioxoboron	HBS1L LDHAL6B LDHC ENTPD1	1.85e-04	59	109	4	CID006327264
Drug	17-AAG; Up 200; 1uM; MCF7; HT_HG-U133A_EA	NUCB2 RRBP1 CUL5 PDS5A EIF2AK3 GOLGB1	1.93e-04	174	109	6	1063_UP
Drug	2-acetolactate	LDHAL6B LDHC DLD	2.01e-04	24	109	3	CID000000022
Drug	(-)-Quinpirole hydrochloride [85760-74-3]; Down 200; 15.6uM; HL60; HT_HG-U133A	GTPBP4 CLTCL1 POLR2C COA4 SRCAP NOC4L	2.18e-04	178	109	6	2977_DN
Drug	spirobishexahydropyrimidine	LDHAL6B LDHC	2.25e-04	5	109	2	CID000100750
Drug	AC1O5TJF	LDHAL6B LDHC	2.25e-04	5	109	2	CID006440410
Drug	1,4-diethoxybutane	LDHAL6B LDHC	2.25e-04	5	109	2	CID000232578
Drug	S-lac-NAD	LDHAL6B LDHC	2.25e-04	5	109	2	CID000194292
Drug	sorbarin	LDHAL6B LDHC	2.25e-04	5	109	2	CID009824100
Drug	AC1O5ZB9	LDHAL6B LDHC	2.25e-04	5	109	2	CID006443605
Drug	AC1L49DG	LDHAL6B LDHC	2.25e-04	5	109	2	CID000152931
Drug	N-trifluoroacetyl-glycine	LDHAL6B LDHC	2.25e-04	5	109	2	CID000136227
Drug	acetylphosphonic acid	LDHAL6B LDHC	2.25e-04	5	109	2	CID000081311
Drug	NSC-60195	LDHAL6B LDHC	2.25e-04	5	109	2	CID000020481
Drug	ethyl gossypol	LDHAL6B LDHC	2.25e-04	5	109	2	CID000374353
Drug	oxyayanin A	LDHAL6B LDHC	2.25e-04	5	109	2	CID005281676
Drug	B-HAD	LDHAL6B LDHC	2.25e-04	5	109	2	CID000131338
Drug	SQ 31,486	LDHAL6B LDHC	2.25e-04	5	109	2	CID000130015
Drug	BMS-188107	LDHAL6B LDHC	2.25e-04	5	109	2	CID000192297
Drug	succinate	RRM2B ETFDH LDHAL6B ACOT4 LDHC LAP3 FANCD2 DLD	2.29e-04	339	109	8	CID000001110
Drug	l 3000	LDHAL6B LDHC LAP3	2.87e-04	27	109	3	CID000102475
Drug	LY 294002; Down 200; 10uM; HL60; HT_HG-U133A	GON4L NKIRAS2 CUL5 SVIL PDS5A MAP4K4	3.01e-04	189	109	6	1168_DN
Drug	Sygen	B3GLCT CLTCL1 SPEG CLTC PROC	3.05e-04	122	109	5	CID006434235
Drug	Pentetic acid [67-43-6]; Down 200; 10.2uM; MCF7; HT_HG-U133A	WDR33 SPEG ARHGEF12 SRCAP PIGC TMC5	3.19e-04	191	109	6	3387_DN
Drug	GSK-3beta Inhibitor VIII; Down 200; 10uM; MCF7; HT_HG-U133A	INPP5B MINK1 RRBP1 MAP3K5 MKNK1 CES3	3.28e-04	192	109	6	7092_DN
Drug	BL-443	LDHAL6B LDHC	3.36e-04	6	109	2	CID000054436
Drug	dansyl-L-lysine	LDHAL6B LDHC	3.36e-04	6	109	2	CID000598797
Drug	I 65	LDHAL6B LDHC	3.36e-04	6	109	2	CID000149068
Drug	D 701	LDHAL6B LDHC	3.36e-04	6	109	2	CID003051460
Drug	2,3-dihydroxy-1-naphthoic acid	LDHAL6B LDHC	3.36e-04	6	109	2	CID000028002
Drug	AC1L1IPS	CLTCL1 CLTC	3.36e-04	6	109	2	CID000004682
Drug	AC1L24G8	LDHAL6B LDHC	3.36e-04	6	109	2	CID000066023
Drug	oxymethacil	LDHAL6B LDHC	3.36e-04	6	109	2	CID000096369
Drug	SQ 32,926	LDHAL6B LDHC	3.36e-04	6	109	2	CID000131363
Drug	Epitiostanol [2363-58-8]; Up 200; 13uM; MCF7; HT_HG-U133A	HBS1L SPEG CCNK PCNX2 RASIP1 CES3	3.37e-04	193	109	6	4788_UP
Drug	Flucytosine [2022-85-7]; Down 200; 31uM; MCF7; HT_HG-U133A	INPP5B POLR2C RRBP1 USP7 PDS5A GOLGB1	3.37e-04	193	109	6	5289_DN
Drug	Dropropizine (R,S) [17692-31-8]; Up 200; 17uM; MCF7; HT_HG-U133A	INPP5B GON4L RRBP1 DENND3 PIGC ENTPD1	3.47e-04	194	109	6	5531_UP
Drug	2-propylpentanoic acid; Up 200; 50uM; MCF7; HT_HG-U133A_EA	ATP13A2 CCNK VPS13D SEL1L3 KLHDC10 GOLGB1	3.47e-04	194	109	6	1060_UP
Drug	chlorpromazine hydrochloride; Down 200; 1uM; PC3; HT_HG-U133A	DPYSL3 MINK1 ARHGEF12 NUP214 MAP3K5 PRRC2B	3.47e-04	194	109	6	1217_DN
Drug	Mefenamic acid [61-68-7]; Down 200; 16.6uM; MCF7; HT_HG-U133A	GTPBP4 GON4L CHD3 RRBP1 ATP13A2 VPS13D	3.47e-04	194	109	6	1699_DN
Drug	Demeclocycline hydrochloride [64-73-3]; Up 200; 8uM; MCF7; HT_HG-U133A	HBS1L ARHGEF12 PCNX2 PIGC USP7 SEC14L2	3.47e-04	194	109	6	3404_UP
Drug	Acebutolol hydrochloride [34381-68-5]; Up 200; 10.8uM; PC3; HG-U133A	SPEG ARHGEF12 SRCAP ATP13A2 PRKAB1 PRRC2B	3.56e-04	195	109	6	1911_UP
Drug	Meptazinol hydrochloride [59263-76-2]; Up 200; 14.8uM; MCF7; HT_HG-U133A	INPP5B MINK1 GON4L CCNK VPS13D CES3	3.56e-04	195	109	6	7326_UP
Drug	Neostigmine bromide [114-80-7]; Down 200; 13.2uM; HL60; HT_HG-U133A	MINK1 FNBP1L RRBP1 SRCAP PCNX2 CES3	3.56e-04	195	109	6	2432_DN
Drug	Piperacillin sodium salt [59703-84-3]; Up 200; 7.4uM; MCF7; HT_HG-U133A	HBS1L MINK1 CUL9 MAP3K5 VPS13D CES3	3.66e-04	196	109	6	3420_UP
Drug	Pirenzepine dihydrochloride [29868-97-1]; Down 200; 9.4uM; MCF7; HT_HG-U133A	POLR2C RRBP1 PCNX2 VPS13D KLHL9 PRRC2B	3.66e-04	196	109	6	7226_DN
Drug	Isoconazole [27523-40-6]; Down 200; 9.6uM; PC3; HT_HG-U133A	ARHGEF12 CUL9 PCNX2 ATXN2 SVIL TMC5	3.66e-04	196	109	6	2056_DN
Drug	Miconazole [22916-47-8]; Down 200; 9.6uM; PC3; HT_HG-U133A	INPP5B POLR2C GON4L PCNX2 VPS13D USP7	3.66e-04	196	109	6	6615_DN
Drug	Mafenide hydrochloride [138-37-4]; Down 200; 18uM; PC3; HT_HG-U133A	INPP5B ARHGEF12 CHD3 NKIRAS2 ATP13A2 PIGC	3.66e-04	196	109	6	5079_DN
Drug	Piroxicam [36322-90-4]; Down 200; 12uM; PC3; HT_HG-U133A	INPP5B GON4L CHD3 ATP13A2 DENND3 SEC14L2	3.66e-04	196	109	6	2089_DN
Drug	Glutethimide, para-amino [125-84-8]; Down 200; 17.2uM; HL60; HT_HG-U133A	ARHGEF12 RRBP1 SRCAP PCNX2 KLHL9 SVIL	3.66e-04	196	109	6	2390_DN
Drug	SB 202190; Up 200; 1uM; MCF7; HT_HG-U133A	INPP5B POLR2C MINK1 GON4L CHD3 MAP3K5	3.66e-04	196	109	6	7054_UP
Drug	Dizocilpine maleate [77086-22-7]; Down 200; 11.8uM; MCF7; HT_HG-U133A	HBS1L MINK1 ARHGEF12 GON4L PCNX2 ENTPD1	3.66e-04	196	109	6	2232_DN
Drug	Scopolamin-N-oxide hydrobromide [6106-81-6]; Down 200; 10uM; PC3; HT_HG-U133A	INPP5B ARHGEF12 CUL9 KLHL9 SVIL PRRC2B	3.66e-04	196	109	6	2099_DN
Disease	platelet crit	DPF1 HBS1L ARHGEF12 ACTN1 RRBP1 FAM13B ATXN2 SVIL ENTPD1 PRKAB1 USP7 FHIP1A SEC14L2	3.41e-05	952	105	13	EFO_0007985
Disease	cardiovascular event measurement, response to placebo	ACOT6 ACOT4	3.75e-05	3	105	2	EFO_0006919, EFO_0008344
Disease	disease of metabolism (implicated_via_orthology)	LDHAL6B LDHC DLD	5.56e-05	21	105	3	DOID:0014667 (implicated_via_orthology)
Disease	Inflammatory Myofibroblastic Tumor	RANBP2 CLTC	1.86e-04	6	105	2	C0334121
Disease	X-16935 measurement	ACOT6 ACOT4	2.60e-04	7	105	2	EFO_0800763
Disease	cortical surface area measurement	DPYSL3 ARHGEF12 CUL9 ACTRT2 ARHGAP39 FNBP1L ATP13A2 DENND3 ATXN2 RASGEF1B KCNK10 XRN1 MAP4K4 PROC	2.97e-04	1345	105	14	EFO_0010736
Disease	X-24747 measurement	ACOT6 ACOT4	3.46e-04	8	105	2	EFO_0022135
Disease	response to darapladib, cardiovascular event measurement	ACOT6 ACOT4	3.46e-04	8	105	2	EFO_0006919, EFO_0008395
Disease	X-17653 measurement	ACOT6 ACOT4	4.44e-04	9	105	2	EFO_0800783
Disease	left ventricular systolic function measurement	OBSCN ATXN2 ALPK3	5.22e-04	44	105	3	EFO_0008206
Disease	event free survival time, type 1 diabetes mellitus, autoantibody measurement	ACTRT2 ATXN2	8.09e-04	12	105	2	EFO_0000482, EFO_0004866, MONDO_0005147
Disease	brain disease (is_implicated_in)	RANBP2 NUP214	8.09e-04	12	105	2	DOID:936 (is_implicated_in)
Disease	von Willebrand factor measurement, coagulation factor measurement	VPS8 EPB41L4A	8.09e-04	12	105	2	EFO_0004629, EFO_0004634
Disease	cerebellar volume measurement	DENND3 EIF2AK3 PROC	8.52e-04	52	105	3	EFO_0020864
Disease	undecenoylcarnitine (C11:1) measurement	ACOT6 ACOT4	9.54e-04	13	105	2	EFO_0800588
Disease	chenodeoxycholate measurement	HMCN1 KCNK10	1.28e-03	15	105	2	EFO_0010471
Disease	chronic kidney disease	GTPBP4 DSCAM ETFDH MKNK1 MICALL2	1.55e-03	235	105	5	EFO_0003884
Disease	Parkinson disease	ATP13A2 ATXN2	2.77e-03	22	105	2	cv:C0030567
Disease	low density lipoprotein cholesterol measurement, response to escitalopram, response to citalopram	DPP6 ACTRT2	3.29e-03	24	105	2	EFO_0004611, EFO_0006329, EFO_0007871
Disease	coronary artery disease	DPP6 HBS1L CLTCL1 DSCAM WDR33 ARHGEF12 ACTRT2 RRBP1 EPB41L4A ATXN2 RASGEF1B	3.52e-03	1194	105	11	EFO_0001645
Disease	cleft lip	GVINP1 SVIL ENTPD1 KCNK10 CNTN2	3.52e-03	284	105	5	EFO_0003959

Protein segments in the cluster

Peptide	Gene	Start	Entry
KEATAPGKWKSHEQV	CHTF18	336	Q8WVB6
DEWFTLDEVPKGKLH	ESYT2	486	A0FGR8
QKASIHEAWTDGKEA	ACTN1	401	P12814
LPGKTQDEVQQHEKW	CCDC112	196	Q8NEF3
PSKEWFLGKALHDEE	B3GLCT	151	Q6Y288
DVHAVCLWDDKGPAK	CUL5	46	Q93034
ISTKHSEDWGKEEGQ	CATSPER1	386	Q8NEC5
AALDPENHGKKQWDL	EIF2AK3	116	Q9NZJ5
KHLFEWELGVKPSDQ	ACTRT2	91	Q8TDY3
KELAWVPEAQRKHTA	DPF1	246	Q92782
IWDPDAVKIVSAKNH	DPYSL3	411	Q14195
TKPGADHDWENLEKD	GVINP1	791	Q7Z2Y8
NLSEKHDKIPEIWEG	GTPBP4	421	Q9BZE4
REIEQSWKHEKAVPG	ALPK3	396	Q96L96
SWKHEKAVPGEVDTL	ALPK3	401	Q96L96
WDKKDLAHTPSQLEG	CCNK	26	O75909
GEPKAHSKAQVDAWQ	ACOT6	386	Q3I5F7
GGEALNPDVREKWKH	ACSM5	346	Q6NUN0
NPDVREKWKHQTGVE	ACSM5	351	Q6NUN0
EDAHPKLWCALSEGK	DENND3	911	A2RUS2
PKHAKEGNGFQEETW	CGAS	361	Q8N884
WFSGPGEEKLKHAAA	ARHGEF12	871	Q9NZN5
WEKIKEIGDRQPENH	RASIP1	611	Q5U651
DRFALVTPKKEGHWD	RANBP2	1406	P49792
LHGEAGKEAAEKVSW	PDS5A	431	Q29RF7
ADPLHVALEVATKGW	ARHGAP39	761	Q9C0H5
VKGITLHDEPVDWAA	HBS1L	531	Q9Y450
LGKKAAGIDEQENWH	LAP3	101	P28838
ILHNDPEVEKKQGWT	MAP4K4	1001	O95819
DIQAKDLGIWHVPNK	ITLN1	141	Q8WWA0
DHGAEANVKAKLPVW	ASB12	151	Q8WXK4
KVNGEHKEKDLEPWD	ATXN2	361	Q99700
PHLDLKNVSDGDKWE	FAM13B	466	Q9NYF5
PAGWDNEKKIAILHE	DYNC1LI2	311	O43237
VQSWKEEEKKPHLQG	MICALL2	691	Q8IY33
FEKKVVICHEGDPAW	PCNX2	1721	A6NKB5
TNAWEEIATKPHEKI	KLHDC10	296	Q6PID8
DIGTDKDPEQWKNVH	LDHAL6B	266	Q9BYZ2
GTDLEQKLHWNPEDK	DRAM2	186	Q6UX65
RPGGNEEAKKKAWEH	FGFBP2	191	Q9BYJ0
DPDVAQHWAKSEKVK	NKIRAS2	131	Q9NYR9
KDEWHKVFDLPESLG	KLHL9	571	Q9P2J3
PKLGTDSDKEHWKNI	LDHC	216	P07864
PAVAEKQGHQWKDSD	NUP214	686	P35658
EEVGEIKAHAAEWKA	KCNK10	331	P57789
KWPAEKENDTGVVHQ	ENTPD1	66	P49961
NHPGSKDQLKEVWEE	NUCB2	221	P80303
EGPENHIEKDRWKSL	RASGEF1B	451	Q0VAM2
WQKDGQPLLEDDHHK	HMCN1	2906	Q96RW7
ELSKAAPVEWRKGHE	OBSCN	3736	Q5VST9
HGHIRDKEAPQKSWA	PROC	446	P04070
IDEKNWKPGRVDHTV	ETFDH	281	Q16134
AVPEGAWKDTAQLHK	ATP13A2	136	Q9NQ11
SLPTKLEEKGEEWHC	FHIP1A	256	Q05DH4
HKNEAWLSEVEGKTG	FNBP1L	466	Q5T0N5
AKALWDSVHKTPGEV	CENPL	261	Q8N0S6
PHCEKEGVQWEAKEE	CHD3	421	Q12873
NHDKETEWPDGAKDC	GON4L	1836	Q3T8J9
SKEERDPVKAHEGWG	CNTN2	136	Q02246
HPEVAWVGKSEEQLK	DLD	396	P09622
KAKTWIPEVHDQKAD	DDX24	176	Q9GZR7
IPEVHDQKADVSAWK	DDX24	181	Q9GZR7
EWFKAVSEGLHPDAK	INPP5B	401	P32019
INHDEVWFKRPDGSK	BRMS1L	291	Q5PSV4
EDKCWEKVEVSSNPH	CUL9	1166	Q8IWT3
FKIHDPEAKWISDTE	DPP6	141	P42658
SKICVNGDDAHPLWK	GPX4	131	P36969
IKPAWVKADHGAEGA	CES3	451	Q6UWW8
ELWKHIQKELVDPSG	EPB41L4A	551	Q9HCS5
GANWKEVLLKHISPD	SEC14L2	221	O76054
VQLEGAHPLEKSKWE	NOC4L	126	Q9BVI4
HFSPAELEWVTKEKG	NEURL4	1536	Q96JN8
VETKKPEVASWVHFD	CEBPZ	671	Q03701
HVAVQWLEAAPKERG	KBTBD6	241	Q86V97
HEKLDPKALEWVGHT	FANCD2	641	Q9BXW9
QTAEGIRKAHPDKDW	MIOX	101	Q9UGB7
PDKDWAHISSEAKDL	MKNK1	336	Q9BUB5
HNDPEVEKKQGWTTV	MINK1	1096	Q8N4C8
VLPDDKKGIHEWNFS	MAP3K5	591	Q99683
AHGEKPIIVRWEKED	DSCAM	811	O60469
EACQEGIVHWKPSEK	RTP2	156	Q5QGT7
DPEKAVVWAKHVAEK	SEL1L3	856	Q68CR1
KHEWFLQKDSEGDTP	SVIL	281	O95425
DSIIWDGEDIKHKGT	TAF1L	431	Q8IZX4
AKWENEKPRVHAGVD	RASGRP3	651	Q8IV61
IPGHSAEEKQSVWQK	VPS8	946	Q8N3P4
KENIHGPWDEAEIKE	PIGC	276	Q92535
DLANKGPKWEKSHAE	SRCAP	81	Q6ZRS2
GPKWEKSHAEIAEQA	SRCAP	86	Q6ZRS2
EEIQKPEEKVTWDGH	SF3A1	491	Q15459
KEHAKWNPTAGVAFE	POLR2C	171	P19387
GEPRAHSKAQEDAWK	ACOT4	386	Q8N9L9
EIKAPEKEEFLAWQH	PRKAB1	51	Q9Y478
HPTDAWKEGQFKDII	CLTC	1381	Q00610
HPTEAWKEGQFKDII	CLTCL1	1381	P53675
PQGHTWTQRVKKDDE	COA4	6	Q9NYJ1
AEEVDLSKDLPHWNK	RRM2B	66	Q7LG56
HAKIMADNPSWDGEK	PRPF8	2196	Q6P2Q9
TETEDPVKFHEAWQK	CTPS2	346	Q9NRF8
WKDGETNDKEVPVPH	ZNF616	101	Q08AN1
IQDTWHKATQKGDPV	RRBP1	681	Q9P2E9
EETLEHPWFKTQAKG	SPEG	1846	Q15772
DKAPVEKEGIHVLDW	PTP4A2	51	Q12974
HGWNPKDCSENIEVK	SPSB2	46	Q99619
GPWAENDHLKKETSG	TTBK2	601	Q6IQ55
PSKVVHLGDKEQSNW	XRN1	756	Q8IZH2
PDEKKPECGSWDVSH	PRRC2B	861	Q5JSZ5
GWKEEFKADVSVPHT	STMND1	21	H3BQB6
ECDWHKSPQGQKLIA	TMC5	341	Q6UXY8
KKEATAVAWHPVHEG	WDR33	331	Q9C0J8
QADAPHGVAWDSKKH	USP7	196	Q93009
VKDNWKHVQDIDVGP	VPS13D	831	Q5THJ4
CTGSSEHWKPELEEK	GOLGB1	1151	Q14789