Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	structural constituent of eye lens	CRYGB CRYGC	4.08e-04	24	25	2	GO:0005212
Domain	LAM_G_DOMAIN	LAMA3 CELSR1 NRXN2	1.53e-05	38	24	3	PS50025
Domain	Laminin_G_2	LAMA3 CELSR1 NRXN2	1.79e-05	40	24	3	PF02210
Domain	LamG	LAMA3 CELSR1 NRXN2	2.39e-05	44	24	3	SM00282
Domain	Laminin_G	LAMA3 CELSR1 NRXN2	5.49e-05	58	24	3	IPR001791
Domain	Crystall	CRYGB CRYGC	1.64e-04	15	24	2	PF00030
Domain	CRYSTALLIN_BETA_GAMMA	CRYGB CRYGC	1.64e-04	15	24	2	PS50915
Domain	Beta/gamma_crystallin	CRYGB CRYGC	1.64e-04	15	24	2	IPR001064
Domain	XTALbg	CRYGB CRYGC	1.64e-04	15	24	2	SM00247
Domain	-	LAMA3 CELSR1 NRXN2	2.39e-04	95	24	3	2.60.120.200
Domain	G_crystallin-rel	CRYGB CRYGC	2.39e-04	18	24	2	IPR011024
Domain	EGF_LAM_2	LAMA3 CELSR1	6.73e-04	30	24	2	PS50027
Domain	EGF_LAM_1	LAMA3 CELSR1	6.73e-04	30	24	2	PS01248
Domain	Laminin_EGF	LAMA3 CELSR1	9.18e-04	35	24	2	PF00053
Domain	EGF_Lam	LAMA3 CELSR1	9.18e-04	35	24	2	SM00180
Domain	Laminin_EGF	LAMA3 CELSR1	1.08e-03	38	24	2	IPR002049
Domain	ConA-like_dom	LAMA3 CELSR1 NRXN2	2.68e-03	219	24	3	IPR013320
Domain	EGF	LAMA3 CELSR1 NRXN2	3.27e-03	235	24	3	SM00181
Domain	RNaseH-like_dom	ZBED6 ZMYM6	3.52e-03	69	24	2	IPR012337
Domain	EGF-like_dom	LAMA3 CELSR1 NRXN2	3.85e-03	249	24	3	IPR000742
Domain	EGF_1	LAMA3 CELSR1 NRXN2	4.12e-03	255	24	3	PS00022
Domain	EGF-like_CS	LAMA3 CELSR1 NRXN2	4.39e-03	261	24	3	IPR013032
Domain	EGF_2	LAMA3 CELSR1 NRXN2	4.59e-03	265	24	3	PS01186
Domain	EGF	CELSR1 NRXN2	1.13e-02	126	24	2	PF00008
Domain	Growth_fac_rcpt_	LAMA3 CELSR1	1.70e-02	156	24	2	IPR009030
Pubmed	Two human gamma-crystallin genes are linked and riddled with Alu-repeats.	CRYGB CRYGC	5.80e-07	2	27	2	4065573
Pubmed	Nucleotide sequence of the rat gamma-crystallin gene region and comparison with an orthologous human region.	CRYGB CRYGC	5.80e-07	2	27	2	2777080
Pubmed	A crystallin mutant cataract with mineral deposits.	CRYGB CRYGC	5.80e-07	2	27	2	37331601
Pubmed	Genomic sequences of murine gamma B- and gamma C-crystallin-encoding genes: promoter analysis and complete evolutionary pattern of mouse, rat and human gamma-crystallins.	CRYGB CRYGC	1.74e-06	3	27	2	8293998
Pubmed	Methylation and carbamylation of human gamma-crystallins.	CRYGB CRYGC	1.74e-06	3	27	2	12876325
Pubmed	The gamma-crystallins and human cataracts: a puzzle made clearer.	CRYGB CRYGC	1.74e-06	3	27	2	10521291
Pubmed	Temporal regulation of six crystallin transcripts during mouse lens development.	CRYGB CRYGC	3.48e-06	4	27	2	1623964
Pubmed	Genetic and allelic heterogeneity of Cryg mutations in eight distinct forms of dominant cataract in the mouse.	CRYGB CRYGC	3.48e-06	4	27	2	15037589
Pubmed	Assignment of the human gamma-crystallin gene cluster (CRYG) to the long arm of chromosome 2, region q33-36.	CRYGB CRYGC	3.48e-06	4	27	2	3011643
Pubmed	Partially folded aggregation intermediates of human gammaD-, gammaC-, and gammaS-crystallin are recognized and bound by human alphaB-crystallin chaperone.	CRYGB CRYGC	3.48e-06	4	27	2	20621668
Pubmed	Differential regulation of gamma-crystallin genes during mouse lens development.	CRYGB CRYGC	3.48e-06	4	27	2	3792630
Pubmed	The mouse eye lens obsolescence (Elo) mutant: studies on crystallin gene expression and linkage analysis between the mutant locus and the gamma-crystallin genes.	CRYGB CRYGC	3.48e-06	4	27	2	3428594
Pubmed	Novel mutations in the gamma-crystallin genes cause autosomal dominant congenital cataracts.	CRYGB CRYGC	3.48e-06	4	27	2	12011157
Pubmed	Homology models of human gamma-crystallins: structural study of the extensive charge network in gamma-crystallins.	CRYGB CRYGC	3.48e-06	4	27	2	12507494
Pubmed	The crystallins: genes, proteins and diseases.	CRYGB CRYGC	5.80e-06	5	27	2	9426193
Pubmed	Structure of the crystallins.	CRYGB CRYGC	5.80e-06	5	27	2	10627816
Pubmed	Human gamma-crystallin genes. A gene family on its way to extinction.	CRYGB CRYGC	8.69e-06	6	27	2	2258929
Pubmed	Gamma-crystallins of the human eye lens: expression analysis of five members of the gene family.	CRYGB CRYGC	8.69e-06	6	27	2	3670288
Pubmed	Sox1 directly regulates the gamma-crystallin genes and is essential for lens development in mice.	CRYGB CRYGC	2.60e-05	10	27	2	9512512
Pubmed	ZBED evolution: repeated utilization of DNA transposons as regulators of diverse host functions.	ZBED6 ZMYM6	2.60e-05	10	27	2	23533661
Pubmed	Regulation of lens fiber cell differentiation by transcription factor c-Maf.	CRYGB CRYGC	2.60e-05	10	27	2	10383433
Pubmed	Disruption of Trkb-mediated signaling induces disassembly of postsynaptic receptor clusters at neuromuscular junctions.	CRYGB CRYGC	3.18e-05	11	27	2	10595510
Pubmed	Shotgun identification of protein modifications from protein complexes and lens tissue.	CRYGB CRYGC	3.18e-05	11	27	2	12060738
Pubmed	E2F1 mediates ectopic proliferation and stage-specific p53-dependent apoptosis but not aberrant differentiation in the ocular lens of Rb deficient fetuses.	CRYGB CRYGC	3.18e-05	11	27	2	11146559
Pubmed	Multiple developmental defects derived from impaired recruitment of ASC-2 to nuclear receptors in mice: implication for posterior lenticonus with cataract.	CRYGB CRYGC	3.18e-05	11	27	2	12446761
Pubmed	Altered aggregation properties of mutant gamma-crystallins cause inherited cataract.	CRYGB CRYGC	3.81e-05	12	27	2	12426373
Pubmed	The orchestration of mammalian tissue morphogenesis through a series of coherent feed-forward loops.	CRYGB CRYGC	5.25e-05	14	27	2	21998302
Pubmed	Prox1 function is crucial for mouse lens-fibre elongation.	CRYGB CRYGC	6.06e-05	15	27	2	10080188
Pubmed	Unique contribution of heat shock transcription factor 4 in ocular lens development and fiber cell differentiation.	CRYGB CRYGC	6.92e-05	16	27	2	15593327
Pubmed	HSF4 is required for normal cell growth and differentiation during mouse lens development.	CRYGB CRYGC	7.84e-05	17	27	2	15483628
Pubmed	Regulation of ocular lens development by Smad-interacting protein 1 involving Foxe3 activation.	CRYGB CRYGC	8.81e-05	18	27	2	16162653
Pubmed	Genome-wide association study of periodontal health measured by probing depth in adults ages 18-49 years.	HSP90AB2P STT3B	1.59e-04	24	27	2	24347629
Pubmed	TGFβ attenuates cartilage extracellular matrix degradation via enhancing FBXO6-mediated MMP14 ubiquitination.	LAMA3 MUC5B STT3B	2.77e-04	164	27	3	32409323
Pubmed	Dual regulation of planar polarization by secreted Wnts and Vangl2 in the developing mouse cochlea.	CELSR1 WNT16	3.40e-04	35	27	2	32907846
Pubmed	Malformation of Tear Ducts Underlies the Epiphora and Precocious Eyelid Opening in Prickle 1 Mutant Mice: Genetic Implications for Tear Duct Genesis.	CELSR1 WNT16	6.14e-04	47	27	2	33141892
Interaction	CRYGB interactions	CRYGB CRYGC	1.47e-05	5	25	2	int:CRYGB
Interaction	GEMIN8P4 interactions	CRYGB CRYGC	1.47e-05	5	25	2	int:GEMIN8P4
Interaction	CYP4F3 interactions	CYP4F3 TM4SF20	1.47e-05	5	25	2	int:CYP4F3
Interaction	CRYGC interactions	CRYGB CRYGC	1.33e-04	14	25	2	int:CRYGC
Interaction	TM4SF20 interactions	CYP4F3 TM4SF20	2.49e-04	19	25	2	int:TM4SF20
Cytoband	Ensembl 112 genes in cytogenetic band chr2q33	CRYGB CRYGC	6.47e-03	205	27	2	chr2q33
Cytoband	Ensembl 112 genes in cytogenetic band chr22q13	CELSR1 TMEM184B	1.61e-02	330	27	2	chr22q13
GeneFamily	Beta-gamma crystallins	CRYGB CRYGC	6.70e-05	15	15	2	1359
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Lymphocytic_B-B_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ZNF804A WNT16 SUN5	1.55e-04	174	27	3	1b2a2129c08bac01fc638692313b196759a1e0d7
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-AT_1-AT2_Progenitor\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	LAMA3 CELSR1 EBPL	1.55e-04	174	27	3	d0e3d15731de6c19c232e3aa492c39d8151cf4ed
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Lymphocytic_B-B_Cell-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ZNF804A WNT16 SUN5	1.55e-04	174	27	3	5bde24eb588dc588efc413811379548120ec0c7f
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_2\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GSG1L ZNF804A WNT16	1.58e-04	175	27	3	11f49f00e000cbc137e3540a6d6805cde21d96e6
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_2\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GSG1L ZNF804A WNT16	1.69e-04	179	27	3	3b0f8781232e1d42b6f8913bc989a14b3f978e79
ToppCell	hematopoetic_progenitors-CD34+_MEP_2\|World / Lineage and Cell class	MS4A3 ZNF804A EBPL	1.77e-04	182	27	3	a7e7aa10f14111a6c7ba22e0f1668dcaa124714d
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_1\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	LAMA3 CELSR1 EBPL	1.80e-04	183	27	3	ff6dde877659cde9daa3263db0932c9c9ef1adac
ToppCell	LPS-IL1RA-Epithelial_alveolar-AT_1\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	LAMA3 CELSR1 EBPL	1.83e-04	184	27	3	cdf6f1c6cce97a7effa0c55959652e2c0b6992b3
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_1-AT2_Progenitor\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	LAMA3 CELSR1 EBPL	1.83e-04	184	27	3	7cc5796557379c3d1db078c1aeda40659c6e401c
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-AT_1\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	LAMA3 CELSR1 EBPL	1.86e-04	185	27	3	c82eab551f65ecebe6db908eda9f9eb3414693c7
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_1-AT1-AT2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	LAMA3 CELSR1 EBPL	1.86e-04	185	27	3	3bef59cc0aa939d2a7e52f0f6c61bc00528fe50b
ToppCell	LPS-antiTNF-Epithelial_alveolar\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	LAMA3 CELSR1 EBPL	1.92e-04	187	27	3	201ff693e4756ee3e44762885b3a303a77eb535b
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	LAMA3 CELSR1 EBPL	1.95e-04	188	27	3	43a0508d2524a5b310e89e9422843dcaab999bc3
ToppCell	LPS-IL1RA-Epithelial_alveolar-AT_1-AT2_Progenitor\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	LAMA3 CELSR1 EBPL	1.98e-04	189	27	3	5f883ef4cc0383142d538ae61f4fb40dfdb8ef18
ToppCell	390C-Epithelial_cells-Epithelial-I_(AT1)-\|390C / Donor, Lineage, Cell class and subclass (all cells)	LAMA3 UBR2 CELSR1	2.14e-04	194	27	3	a71728202493d4858342ea2756ea281cd0d99a3a
ToppCell	390C-Epithelial_cells-Epithelial-I_(AT1)\|390C / Donor, Lineage, Cell class and subclass (all cells)	LAMA3 UBR2 CELSR1	2.14e-04	194	27	3	88db9f9e80c20ff3474f1f6459dcbdc25aec0b6d
ToppCell	Control_saline-Epithelial_alveolar-AT_1-Differentiating_AT1\|Control_saline / Treatment groups by lineage, cell group, cell type	LAMA3 CELSR1 EBPL	2.27e-04	198	27	3	85f424cd9bb3117c9e322031024aabb87696ce47
ToppCell	LPS_IL1RA_TNF-Epithelial_alveolar-AT_1\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	LAMA3 CELSR1 EBPL	2.31e-04	199	27	3	1c70e7d6bd25980e1b92aa1cac3f3c95d9651b4b
ToppCell	Neuronal-Excitatory-eH(THEMIS)-FGF10---L5-6\|Neuronal / cells hierarchy compared to all cells using T-Statistic	GSG1L ZNF804A STT3B	2.34e-04	200	27	3	67ba7e5703842e38fa3508ac644461489043626f
ToppCell	Neuronal-Excitatory-eH(THEMIS)-FGF10-\|Neuronal / cells hierarchy compared to all cells using T-Statistic	GSG1L ZNF804A STT3B	2.34e-04	200	27	3	0248fe1eac23704687a2f11c6a3775bceae7a2b1
ToppCell	Neuronal-Excitatory-eH(THEMIS)-FGF10--\|Neuronal / cells hierarchy compared to all cells using T-Statistic	GSG1L ZNF804A STT3B	2.34e-04	200	27	3	f545ae8486bd72159247e055f0bb2796c254af61
ToppCell	Neuronal-Excitatory-eH(THEMIS)-FGF10\|Neuronal / cells hierarchy compared to all cells using T-Statistic	GSG1L ZNF804A STT3B	2.34e-04	200	27	3	8acccefa60031541277fe6c1a7f58f7450961836
Disease	inferior parietal cortex volume measurement	CRYGB CRYGC	1.37e-04	19	27	2	EFO_0010307
Disease	corpus callosum posterior volume measurement	ZNF804A WNT16	1.04e-03	52	27	2	EFO_0010298
Disease	response to calcium channel blocker	GML EBPL	1.20e-03	56	27	2	EFO_0007767
Disease	susceptibility to scarlet fever measurement	CELSR1 PRSS58	2.38e-03	79	27	2	EFO_0008409
Disease	treatment-resistant hypertension	GML EBPL	4.47e-03	109	27	2	EFO_1002006
Disease	cranial vault morphology measurement	LAMA3 RNF32-DT	5.47e-03	121	27	2	EFO_0009278
Disease	Intellectual Disability	NRXN2 ZMYM6 STT3B	7.71e-03	447	27	3	C3714756
Disease	osteoarthritis, knee	HSP90AB2P RNF32-DT	9.16e-03	158	27	2	EFO_0004616

Protein segments in the cluster

Peptide	Gene	Start	Entry
CLAWGSFTCCMAASV	GSG1L	221	Q6UXU4
LMSTIQESYCSNWRC	C14orf28	146	Q4W4Y0
GGTCVNRWNMYLCEC	CELSR1	1661	Q9NYQ6
CECICSMWGGSHYST	MUC5B	5071	Q9HC84
CVSCFVGLAVCVWMQ	RNF32-DT	186	Q8NI28
CWCSALGSYQMPCSS	LAMA3	536	Q16787
SCCIVTSTYSWTANM	HSP90AB2P	361	Q58FF8
CLQQWDGFTCDCTMT	NRXN2	1111	Q9P2S2
QITLCVCELYGCWMT	EBPL	131	Q9BY08
WLTCSCQGMLTCVGV	ITFG2	56	Q969R8
RSQMWTITGEYCCSC	CALHM4	71	Q5JW98
YQQWMGLSDSIRSCC	CRYGB	66	P07316
YQQWMGLSDSIRSCC	CRYGC	66	P07315
YTQSLACTFGDMCCW	CYP4F3	76	Q08477
TNSFYWVCCCNSMVC	GML	96	Q99445
CGWACTQAMSTRSNC	FAM87A	101	P0C7U9
CVTISTIAMWCNANC	MS4A3	186	Q96HJ5
TMCSVSTWSYNVCDI	PRSS58	131	Q8IYP2
SSCMYGTCCLWGKTY	TMEM184B	151	Q9Y519
MTCCEGWTSCNGFSL	TM4SF20	1	Q53R12
TCTGCMQYFCWICMG	RNF14	421	Q9UBS8
GLTQCMLGCVSWFTC	SUN5	61	Q8TC36
MLGCVSWFTCFACSL	SUN5	66	Q8TC36
VKTGSVFWTMCCCLS	STT3B	241	Q8TCJ2
WCCYVRCRRCESMTD	WNT16	346	Q9UBV4
LSCPMCSWQSECIFT	ZBED6	906	P86452
WGNYCKMCSYCSQTS	ZMYM6	511	O95789
MCWGSCAYTIQSIER	UBR2	1331	Q8IWV8
TYCCWKTKMSSCSQD	ZNF804A	721	Q7Z570