Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ATP-dependent chromatin remodeler activity	CHD8 CHD6 RAD54L	6.40e-05	37	42	3	GO:0140658
GeneOntologyMolecularFunction	N-acetylglucosamine 6-O-sulfotransferase activity	CHST1 CHST7	9.01e-05	7	42	2	GO:0001517
GeneOntologyMolecularFunction	catalytic activity, acting on DNA	CHD8 CHD6 DCLRE1C POLD1 RAD54L	2.14e-04	262	42	5	GO:0140097
GeneOntologyCellularComponent	juxtaparanode region of axon	EPB41L3 LGI3	2.69e-04	12	43	2	GO:0044224
Domain	Band_4.1_C	EPB41L3 EPB41 EPB41L1	4.87e-08	4	44	3	IPR008379
Domain	4_1_CTD	EPB41L3 EPB41 EPB41L1	4.87e-08	4	44	3	PF05902
Domain	SAB	EPB41L3 EPB41 EPB41L1	4.87e-08	4	44	3	PF04382
Domain	SAB_dom	EPB41L3 EPB41 EPB41L1	4.87e-08	4	44	3	IPR007477
Domain	FA	EPB41L3 EPB41 EPB41L1	3.43e-06	13	44	3	SM01195
Domain	FERM-adjacent	EPB41L3 EPB41 EPB41L1	3.43e-06	13	44	3	IPR014847
Domain	FA	EPB41L3 EPB41 EPB41L1	3.43e-06	13	44	3	PF08736
Domain	Ez/rad/moesin-like	EPB41L3 EPB41 EPB41L1	1.58e-05	21	44	3	IPR000798
Domain	FERM_CS	EPB41L3 EPB41 EPB41L1	2.39e-05	24	44	3	IPR019747
Domain	FERM_C	EPB41L3 EPB41 EPB41L1	3.05e-05	26	44	3	PF09380
Domain	FERM_C	EPB41L3 EPB41 EPB41L1	3.43e-05	27	44	3	SM01196
Domain	FERM_PH-like_C	EPB41L3 EPB41 EPB41L1	3.43e-05	27	44	3	IPR018980
Domain	SNF2_N	CHD8 CHD6 RAD54L	5.77e-05	32	44	3	PF00176
Domain	SNF2_N	CHD8 CHD6 RAD54L	5.77e-05	32	44	3	IPR000330
Domain	FERM_N	EPB41L3 EPB41 EPB41L1	6.33e-05	33	44	3	IPR018979
Domain	FERM_N	EPB41L3 EPB41 EPB41L1	6.33e-05	33	44	3	PF09379
Domain	BRK	CHD8 CHD6	8.09e-05	6	44	2	SM00592
Domain	BRK_domain	CHD8 CHD6	8.09e-05	6	44	2	IPR006576
Domain	BRK	CHD8 CHD6	8.09e-05	6	44	2	PF07533
Domain	-	NDUFAF6 FDPS	8.09e-05	6	44	2	1.10.600.10
Domain	Carbohydrate_sulfotransferase	CHST1 CHST7	1.13e-04	7	44	2	IPR016469
Domain	FERM_M	EPB41L3 EPB41 EPB41L1	1.73e-04	46	44	3	PF00373
Domain	Isoprenoid_synthase_dom	NDUFAF6 FDPS	1.93e-04	9	44	2	IPR008949
Domain	FERM_central	EPB41L3 EPB41 EPB41L1	2.08e-04	49	44	3	IPR019748
Domain	FERM_domain	EPB41L3 EPB41 EPB41L1	2.08e-04	49	44	3	IPR000299
Domain	-	EPB41L3 EPB41 EPB41L1	2.08e-04	49	44	3	1.20.80.10
Domain	FERM_1	EPB41L3 EPB41 EPB41L1	2.21e-04	50	44	3	PS00660
Domain	FERM_2	EPB41L3 EPB41 EPB41L1	2.21e-04	50	44	3	PS00661
Domain	Band_41_domain	EPB41L3 EPB41 EPB41L1	2.21e-04	50	44	3	IPR019749
Domain	B41	EPB41L3 EPB41 EPB41L1	2.21e-04	50	44	3	SM00295
Domain	FERM/acyl-CoA-bd_prot_3-hlx	EPB41L3 EPB41 EPB41L1	2.21e-04	50	44	3	IPR014352
Domain	FERM_3	EPB41L3 EPB41 EPB41L1	2.21e-04	50	44	3	PS50057
Domain	TPR	DNAH2 CEP70 SRP72 CDC16	6.05e-04	165	44	4	PS50005
Domain	TPR_REGION	DNAH2 CEP70 SRP72 CDC16	6.05e-04	165	44	4	PS50293
Domain	Chromo_domain	CHD8 CHD6	1.45e-03	24	44	2	IPR023780
Domain	-	DNAH2 ABCG4 CHD8 CHD6 CHST1 CHST7 RAD54L	1.66e-03	746	44	7	3.40.50.300
Domain	Chromo	CHD8 CHD6	1.70e-03	26	44	2	PF00385
Domain	CHROMO_2	CHD8 CHD6	1.97e-03	28	44	2	PS50013
Domain	CHROMO_1	CHD8 CHD6	1.97e-03	28	44	2	PS00598
Domain	Helicase_C	CHD8 CHD6 RAD54L	2.04e-03	107	44	3	PF00271
Domain	HELICc	CHD8 CHD6 RAD54L	2.04e-03	107	44	3	SM00490
Domain	Helicase_C	CHD8 CHD6 RAD54L	2.10e-03	108	44	3	IPR001650
Domain	HELICASE_CTER	CHD8 CHD6 RAD54L	2.15e-03	109	44	3	PS51194
Domain	HELICASE_ATP_BIND_1	CHD8 CHD6 RAD54L	2.15e-03	109	44	3	PS51192
Domain	DEXDc	CHD8 CHD6 RAD54L	2.15e-03	109	44	3	SM00487
Domain	Helicase_ATP-bd	CHD8 CHD6 RAD54L	2.21e-03	110	44	3	IPR014001
Domain	Chromodomain-like	CHD8 CHD6	2.57e-03	32	44	2	IPR016197
Domain	CHROMO	CHD8 CHD6	2.73e-03	33	44	2	SM00298
Domain	Chromo/shadow_dom	CHD8 CHD6	2.73e-03	33	44	2	IPR000953
Domain	DNA/RNA_helicase_DEAH_CS	CHD8 CHD6	3.07e-03	35	44	2	IPR002464
Domain	Sulfotransferase_dom	CHST1 CHST7	3.25e-03	36	44	2	IPR000863
Domain	Sulfotransfer_1	CHST1 CHST7	3.25e-03	36	44	2	PF00685
Domain	P-loop_NTPase	DNAH2 ABCG4 CHD8 CHD6 CHST1 CHST7 RAD54L	3.42e-03	848	44	7	IPR027417
Domain	DEAH_ATP_HELICASE	CHD8 CHD6	3.61e-03	38	44	2	PS00690
Domain	TPR_repeat	CEP70 SRP72 CDC16	3.78e-03	133	44	3	IPR019734
Pubmed	Cardiac muscle cell cytoskeletal protein 4.1: analysis of transcripts and subcellular location--relevance to membrane integrity, microstructure, and possible role in heart failure.	EPB41L3 EPB41 EPB41L1	7.55e-09	4	44	3	15834631
Pubmed	Surface expression of GluR-D AMPA receptor is dependent on an interaction between its C-terminal domain and a 4.1 protein.	EPB41L3 EPB41 EPB41L1	1.89e-08	5	44	3	12574408
Pubmed	Structural diversity of band 4.1 superfamily members.	EPB41L3 EPB41 EPB41L1	1.05e-07	8	44	3	7983158
Pubmed	New insights into potential functions for the protein 4.1 superfamily of proteins in kidney epithelium.	EPB41L3 EPB41 EPB41L1	5.36e-07	13	44	3	16368544
Pubmed	Apoptosis signal-regulating kinase 1 and cyclin D1 compose a positive feedback loop contributing to tumor growth in gastric cancer.	CCND1 MAP3K5	1.56e-06	2	44	2	21187402
Pubmed	Protein 4.1 and the control of ion channels.	EPB41 EPB41L1	1.56e-06	2	44	2	19272819
Pubmed	The 4.1B cytoskeletal protein regulates the domain organization and sheath thickness of myelinated axons.	EPB41L3 EPB41	1.56e-06	2	44	2	23109359
Pubmed	Proviral insertions near cyclin D1 in mouse lymphomas: a parallel for BCL1 translocations in human B-cell neoplasms.	FGF4 CCND1	1.56e-06	2	44	2	1461646
Pubmed	Alterations of protein 4.1 family members in ependymomas: a study of 84 cases.	EPB41L3 EPB41	1.56e-06	2	44	2	15731777
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	TRIM33 SRP72 CHD8 CHD6 SUPT6H ASH2L POLD1 CDC16 EPB41 PIEZO1 EPB41L1	1.87e-06	1497	44	11	31527615
Pubmed	Four paralogous protein 4.1 genes map to distinct chromosomes in mouse and human.	EPB41L3 EPB41 EPB41L1	2.12e-06	20	44	3	9828140
Pubmed	The histone chaperone Spt6 is required for activation-induced cytidine deaminase target determination through H3K4me3 regulation.	AICDA SUPT6H	4.69e-06	3	44	2	22843687
Pubmed	Protein 4.1 expression in the developing hair cells of the mouse inner ear.	EPB41L3 EPB41	4.69e-06	3	44	2	19853587
Pubmed	The ATP-dependent chromatin remodeling enzymes CHD6, CHD7, and CHD8 exhibit distinct nucleosome binding and remodeling activities.	CHD8 CHD6	4.69e-06	3	44	2	28533432
Pubmed	Isoforms of protein 4.1 are differentially distributed in heart muscle cells: relation of 4.1R and 4.1G to components of the Ca2+ homeostasis system.	EPB41L3 EPB41	4.69e-06	3	44	2	22429617
Pubmed	Transcription factor Foxp3 and its protein partners form a complex regulatory network.	SRP72 CHD8 ARIH1 ADAR ASH2L POLD1	6.99e-06	370	44	6	22922362
Pubmed	The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1.	USP34 ARIH1 SUPT6H POLD1 CDC16	7.18e-06	212	44	5	33853758
Pubmed	Analysis of DNA double-strand break repair pathways in mice.	DCLRE1C RAD54L	9.37e-06	4	44	2	16797606
Pubmed	Histone chaperone Spt6 is required for class switch recombination but not somatic hypermutation.	AICDA SUPT6H	9.37e-06	4	44	2	21518874
Pubmed	Protein 4.1B associates with both Caspr/paranodin and Caspr2 at paranodes and juxtaparanodes of myelinated fibres.	EPB41L3 EPB41	9.37e-06	4	44	2	12542678
Pubmed	Regulation of HOXA2 gene expression by the ATP-dependent chromatin remodeling enzyme CHD8.	CHD8 ASH2L	9.37e-06	4	44	2	20085832
Pubmed	Diverging regulation of Bach2 protein and RNA expression determine cell fate in early B cell response.	IRF4 AICDA	1.56e-05	5	44	2	35793628
Pubmed	Band 4.1 proteins regulate integrin-dependent cell spreading.	EPB41L3 EPB41L1	1.56e-05	5	44	2	22982319
Pubmed	DNA-PKcs and Artemis function in the end-joining phase of immunoglobulin heavy chain class switch recombination.	AICDA DCLRE1C	1.56e-05	5	44	2	18316419
Pubmed	The Ash2l SDI Domain Is Required to Maintain the Stability and Binding of DPY30.	CCND1 ASH2L	1.56e-05	5	44	2	35563756
Pubmed	An incoherent regulatory network architecture that orchestrates B cell diversification in response to antigen signaling.	IRF4 AICDA	1.56e-05	5	44	2	21613984
Pubmed	Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.	TRIM33 FGF4 SRP72 CHD8 NDUFAF6 RUBCN FDPS CDC16 PIEZO1	1.77e-05	1215	44	9	15146197
Pubmed	CHARGE and Kabuki syndromes: a phenotypic and molecular link.	CHD8 ASH2L	2.34e-05	6	44	2	24705355
Pubmed	The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells.	USP34 TRIM33 SRP72 CHD8 CHD6	2.84e-05	282	44	5	23667531
Pubmed	Early embryonic death in mice lacking the beta-catenin-binding protein Duplin.	CHD8 CCND1	3.27e-05	7	44	2	15367660
Pubmed	TET enzymes augment activation-induced deaminase (AID) expression via 5-hydroxymethylcytosine modifications at the Aicda superenhancer.	IRF4 AICDA	3.27e-05	7	44	2	31028100
Pubmed	Chromosomal localization and genomic organization for the galactose/ N-acetylgalactosamine/N-acetylglucosamine 6-O-sulfotransferase gene family.	CHST1 CHST7	3.27e-05	7	44	2	11181564
Pubmed	D2 and D3 dopamine receptor cell surface localization mediated by interaction with protein 4.1N.	EPB41 EPB41L1	3.27e-05	7	44	2	12181426
Pubmed	Common genetic variants in candidate genes and risk of familial lymphoid malignancies.	IRF4 CCND1 AICDA RAD54L	3.46e-05	145	44	4	19573080
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	USP34 TRIM33 CHD8 ARIH1 ADAR SUPT6H POLD1 CDC16	3.54e-05	1014	44	8	32416067
Pubmed	HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.	DNAH2 DOCK5 TRIM33 CHD6 SUPT6H FDPS CDC16	4.17e-05	754	44	7	35906200
Pubmed	LEF1 is a critical epithelial survival factor during tooth morphogenesis.	FGF4 CCND1	4.36e-05	8	44	2	15649466
Pubmed	β8 integrin and band 4.1B cooperatively regulate morphogenesis of the embryonic heart.	EPB41L3 EPB41	4.36e-05	8	44	2	21181944
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	USP34 TRIM33 CHD8 SUPT6H FDPS PIEZO1	5.20e-05	529	44	6	14621295
Pubmed	Comprehensive analysis of DNA repair gene variants and risk of meningioma.	DCLRE1C POLD1 RAD54L	5.27e-05	57	44	3	18270339
Pubmed	Regulation of B cell fate by chronic activity of the IgE B cell receptor.	IRF4 AICDA	5.60e-05	9	44	2	27935477
Pubmed	Sulfation of the human immunodeficiency virus envelope glycoprotein.	CHST1 CHST7	6.99e-05	10	44	2	1433500
Pubmed	Complex-type N-linked oligosaccharides of gp120 from human immunodeficiency virus type 1 contain sulfated N-acetylglucosamine.	CHST1 CHST7	8.54e-05	11	44	2	8419650
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	DOCK5 SRP72 CHD8 EPB41L3 POLD1 CDC16	8.80e-05	582	44	6	20467437
Pubmed	Comprehensive screen of genetic variation in DNA repair pathway genes and postmenopausal breast cancer risk.	DCLRE1C POLD1 RAD54L	8.94e-05	68	44	3	20496165
Pubmed	TRIM28 protects TRIM24 from SPOP-mediated degradation and promotes prostate cancer progression.	TRIM33 SUPT6H	1.02e-04	12	44	2	30479348
Pubmed	Customised molecular diagnosis of primary immune deficiency disorders in New Zealand: an efficient strategy for a small developed country.	AICDA DCLRE1C	1.21e-04	13	44	2	19859091
Pubmed	Temporal requirements for ISL1 in sympathetic neuron proliferation, differentiation, and diversification.	CCND1 ECEL1 LMO1	1.29e-04	77	44	3	29445148
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	DOCK5 SRP72 CHD8 ASH2L RUBCN EPB41L1	1.61e-04	650	44	6	38777146
Pubmed	The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets.	SRP72 ARIH1 EPB41L3 EPB41L1	1.89e-04	225	44	4	25277244
Pubmed	Transcriptional intermediary factor 1γ binds to the anaphase-promoting complex/cyclosome and promotes mitosis.	TRIM33 CDC16	2.10e-04	17	44	2	23160376
Pubmed	Chromatin boundaries require functional collaboration between the hSET1 and NURF complexes.	CHD8 ASH2L	2.10e-04	17	44	2	21653943
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	CHD8 ADAR SUPT6H ASH2L CDC16	2.29e-04	440	44	5	34244565
Pubmed	USF1 recruits histone modification complexes and is critical for maintenance of a chromatin barrier.	CHD8 ASH2L	2.36e-04	18	44	2	17846119
Pubmed	Single nucleotide polymorphisms in the Wnt and BMP pathways and colorectal cancer risk in a Spanish cohort.	CCND1 ADAR	2.36e-04	18	44	2	20844743
Pubmed	Risk of non-Hodgkin lymphoma associated with germline variation in genes that regulate the cell cycle, apoptosis, and lymphocyte development.	CCND1 AICDA	2.93e-04	20	44	2	19336552
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	TRIM33 CHD8 CHD6 SUPT6H ASH2L	3.07e-04	469	44	5	27634302
Pubmed	Inflammation-dependent overexpression of c-Myc enhances CRL4DCAF4 E3 ligase activity and promotes ubiquitination of ST7 in colitis-associated cancer.	USP34 ASH2L POLD1 MAP3K5	3.13e-04	257	44	4	30945288
Pubmed	Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity.	IRF4 CCND1 AICDA RAD54L	3.42e-04	263	44	4	19773279
Pubmed	Genome-wide association study identifies five new breast cancer susceptibility loci.	FGF4 CCND1	3.56e-04	22	44	2	20453838
Pubmed	Differential expression and function of ABCG1 and ABCG4 during development and aging.	ABCG4 FDPS	3.56e-04	22	44	2	19633360
Pubmed	TBX3 is essential for establishment of the posterior boundary of anterior genes and upregulation of posterior genes together with HAND2 during the onset of limb bud development.	FGF4 LMO1	3.89e-04	23	44	2	38828908
Pubmed	Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development.	PSMB8 DOCK5 EPB41L3 CTDNEP1 POLD1	3.97e-04	496	44	5	31343991
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	CHD8 EPB41L3 ADAR CDC16 EPB41L1	4.23e-04	503	44	5	16964243
Pubmed	Negative control of Smad activity by ectodermin/Tif1gamma patterns the mammalian embryo.	TRIM33 FGF4	4.24e-04	24	44	2	20573697
Pubmed	Severe anemia in the Nan mutant mouse caused by sequence-selective disruption of erythroid Kruppel-like factor.	CCND1 EPB41	4.61e-04	25	44	2	20696915
Pubmed	Islet1 regulates establishment of the posterior hindlimb field upstream of the Hand2-Shh morphoregulatory gene network in mouse embryos.	FGF4 CCND1	4.61e-04	25	44	2	22438573
Pubmed	Quantitative dissection and stoichiometry determination of the human SET1/MLL histone methyltransferase complexes.	DCLRE1C ASH2L CDC16	4.67e-04	119	44	3	23508102
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	DOCK5 CCND1 CHD6 ARIH1 GPR137C SUPT6H EPB41 EPB41L1	4.96e-04	1489	44	8	28611215
Pubmed	Motor Nerve Arborization Requires Proteolytic Domain of Damage-Induced Neuronal Endopeptidase (DINE) during Development.	CCND1 ECEL1	4.99e-04	26	44	2	27122033
Pubmed	Evidence that autocrine signaling through Bmpr1a regulates the proliferation, survival and morphogenetic behavior of distal lung epithelial cells.	FGF4 CCND1	4.99e-04	26	44	2	16414041
Pubmed	Lack of Prox1 Downregulation Disrupts the Expansion and Maturation of Postnatal Murine β-Cells.	FGF4 CCND1	5.38e-04	27	44	2	26631740
Pubmed	Gamma-radiation sensitivity and polymorphisms in RAD51L1 modulate glioma risk.	DCLRE1C RAD54L	5.38e-04	27	44	2	20610542
Pubmed	Host E3 ligase HUWE1 attenuates the proapoptotic activity of the MERS-CoV accessory protein ORF3 by promoting its ubiquitin-dependent degradation.	TRIM33 CHD8 ADAR POLD1 EPB41	5.55e-04	534	44	5	35032548
Pubmed	ASK1 mediates the teratogenicity of diabetes in the developing heart by inducing ER stress and inhibiting critical factors essential for cardiac development.	CCND1 MAP3K5	5.79e-04	28	44	2	26173459
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	CHD8 ADAR ASH2L CDC16 EPB41	6.29e-04	549	44	5	38280479
Pubmed	A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.	TRIM33 ADAR SUPT6H ASH2L CDC16	6.88e-04	560	44	5	35241646
Pubmed	Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF.	CHD8 ASH2L	7.11e-04	31	44	2	15960975
Pubmed	Mapping the interactome of HPV E6 and E7 oncoproteins with the ubiquitin-proteasome system.	ASB17 ARIH1 CDC16	7.19e-04	138	44	3	28786561
Pubmed	The COMPASS Family Protein ASH2L Mediates Corticogenesis via Transcriptional Regulation of Wnt Signaling.	CCND1 ASH2L	7.57e-04	32	44	2	31315048
Pubmed	The non-canonical BMP and Wnt/β-catenin signaling pathways orchestrate early tooth development.	FGF4 CCND1	7.57e-04	32	44	2	25428587
Pubmed	Cell-Type-Specific Alternative Splicing Governs Cell Fate in the Developing Cerebral Cortex.	EPB41L3 EPB41L1	1.01e-03	37	44	2	27565344
Pubmed	Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells.	ECEL1 ARIH1 EPB41L3 ADAR MYORG	1.03e-03	613	44	5	22268729
Pubmed	The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1.	CHD8 CHD6 ASH2L	1.04e-03	157	44	3	30186101
Pubmed	The Vertebrate Genome Annotation browser 10 years on.	CFAP47 ECEL1 DCLRE1C	1.16e-03	163	44	3	24316575
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	TRIM33 SRP72 CHD8 EPB41L3 ADAR EPB41	1.22e-03	954	44	6	36373674
Interaction	CDC27 interactions	TRIM33 CHD8 CCND1 DCLRE1C ASH2L FDPS CDC16	8.91e-07	249	43	7	int:CDC27
Interaction	SRP9 interactions	USP34 SRP72 CHD8 ARIH1 ADAR SUPT6H CDC16	3.04e-05	427	43	7	int:SRP9
Interaction	NUMA1 interactions	DNAH2 CCND1 EPB41L3 ADAR CDC16 EPB41 EPB41L1	5.52e-05	469	43	7	int:NUMA1
Interaction	KRT222 interactions	EPB41L3 EPB41 EPB41L1	5.65e-05	35	43	3	int:KRT222
GeneFamily	Erythrocyte membrane protein band 4.1\|FERM domain containing	EPB41L3 EPB41 EPB41L1	1.05e-08	4	26	3	951
GeneFamily	Ankyrin repeat domain containing\|FERM domain containing	EPB41L3 EPB41 EPB41L1	4.95e-05	50	26	3	1293
GeneFamily	Sulfotransferases, membrane bound	CHST1 CHST7	1.28e-03	37	26	2	763
GeneFamily	PHD finger proteins	TRIM33 ASH2L	7.37e-03	90	26	2	88
GeneFamily	Tetratricopeptide repeat domain containing\|Bardet-Biedl syndrome associated\|BBSome	SRP72 CDC16	1.18e-02	115	26	2	769
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NDUFAF6 GPR137C POLD1 RAD54L	2.11e-05	165	44	4	88681101d7cf60b99b8ace5d8c0944323b937306
ToppCell	droplet-Lung-1m-Hematologic-myeloid-myeloid_dendritic_cell-proliferating_dendritic\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CCND1 LMO1 POLD1 RAD54L	2.37e-05	170	44	4	badbe200e9d5003d23d115955b10b4ea767f6c26
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NDUFAF6 GPR137C POLD1 RAD54L	2.90e-05	179	44	4	88d44b04eb5c079531db663ed98ddb20b60feb9a
ToppCell	saliva-Severe-critical_progression_d28-40-Myeloid-Dendritic-plasmacytoid_dendritic_cell\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CFAP47 CCDC106 CCND1 RAD54L	3.30e-05	185	44	4	c357fa098b561da16c9fa82b0c3563b5cd3fa875
ToppCell	saliva-Severe-critical_progression_d28-40-Myeloid-Dendritic-plasmacytoid_dendritic_cell-DC_c4-LILRA4\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CFAP47 CCDC106 CCND1 RAD54L	3.30e-05	185	44	4	ef3c1fd52d21d96f81fb0e5097b24be0ce16e222
ToppCell	(2)_Fibroblasts-(21)_Fibro-2\|World / Cell class and subclass of bone marrow stroma cells in homeostatis	ECEL1 LMO1 EPB41L1 LGI3	3.74e-05	191	44	4	5ee353c79055c08e8a3e2b43a0345bceb09f3890
ToppCell	BAL-Control-Myeloid-cDC-cDC-cDC_5\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	FNIP2 IRF4 CCND1 CHST7	3.90e-05	193	44	4	704378de39e1b6f108ab5b0ecbd594d414ec8ae4
ToppCell	BAL-Control-Myeloid-cDC-cDC-cDC_5\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FNIP2 IRF4 CCND1 CHST7	3.98e-05	194	44	4	36f8ae4f2b3bf802f6ff0e9fc79e7f170f96ae8b
ToppCell	10x_3'_v3-spleen_(10x_3'_v3)-myeloid-myeloid_macrophage\|spleen_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	FNIP2 CCND1 ECEL1 EPB41L3	4.30e-05	198	44	4	9aaff68107ae4542f904b142d23669f2fcd557ac
ToppCell	10x_3'_v3-spleen_(10x_3'_v3)-myeloid-myeloid_macrophage-macrophage\|spleen_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	FNIP2 CCND1 ECEL1 EPB41L3	4.30e-05	198	44	4	5aaf3861c53763cf09bb628c9d2eabb6a7277021
ToppCell	(7)_Epithelial_cells-(7)_Epithelial-A_(AT2)\|(7)_Epithelial_cells / Lung cell shreds - cell class (v4) and cell subclass (v4)	FNIP2 TRABD2A EPB41 LGI3	4.39e-05	199	44	4	09cf004032e5af912ee0cdde6e24ce3bcf7673cd
ToppCell	Bronchial-NucSeq-Epithelial-Epi_alveolar-Dividing_AT2\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	EPB41L3 GPR137C POLD1 RAD54L	4.39e-05	199	44	4	1d5a3366474c17e3df0ba5cf11b586655529e9bd
Disease	inflammatory bowel disease (implicated_via_orthology)	EPB41L3 EPB41 EPB41L1	6.03e-06	25	42	3	DOID:0050589 (implicated_via_orthology)
Disease	CHARGE syndrome (implicated_via_orthology)	CHD8 CHD6	4.13e-05	7	42	2	DOID:0050834 (implicated_via_orthology)
Disease	non-Hodgkin lymphoma (is_implicated_in)	CCND1 RAD54L	2.65e-04	17	42	2	DOID:0060060 (is_implicated_in)
Disease	non-melanoma skin carcinoma	DNAH2 IRF4 EPB41 EPB41L1	5.44e-04	265	42	4	EFO_0009260
Disease	lymphocyte measurement	IRF4 NDUFAF6 PIEZO1	6.23e-04	117	42	3	EFO_0803546
Disease	melanoma	IRF4 CCND1 EPB41L1	7.73e-04	126	42	3	EFO_0000756
Disease	Mammary Carcinoma, Human	FGF4 CCND1 EPB41L3 ADAR RAD54L	8.65e-04	525	42	5	C4704874
Disease	Mammary Neoplasms, Human	FGF4 CCND1 EPB41L3 ADAR RAD54L	8.65e-04	525	42	5	C1257931
Disease	Mammary Neoplasms	FGF4 CCND1 EPB41L3 ADAR RAD54L	8.79e-04	527	42	5	C1458155
Disease	Breast Carcinoma	FGF4 CCND1 EPB41L3 ADAR RAD54L	9.64e-04	538	42	5	C0678222
Disease	acute lymphoblastic leukemia (is_marker_for)	CCND1 AICDA	1.08e-03	34	42	2	DOID:9952 (is_marker_for)
Disease	Autoinflammatory disorder	PSMB8 ADAR	1.14e-03	35	42	2	C3860213
Disease	multiple myeloma (is_marker_for)	IRF4 CCND1	1.21e-03	36	42	2	DOID:9538 (is_marker_for)

Protein segments in the cluster

Peptide	Gene	Start	Entry
LTEDITRYYLCLQLR	EPB41	296	P11171
RLLAYLVLRYRVKSE	ABCG4	631	Q9H172
CLDILEDYLIQRRYL	CHD8	1161	Q9HCK8
LRIFTARLYFCEDRK	AICDA	106	Q9GZX7
YYRLTRFLSRVIKCD	CCND1	226	P24385
DLYRACLYERVLLAL	ASH2L	371	Q9UBL3
LDLFEKLCRARRYLY	RAD54L	526	Q92698
KLCRARRYLYVRLDG	RAD54L	531	Q92698
LAKECRLYYLRNGER	PSMB8	131	P28062
YTKANLILCRRDYLR	LMO1	66	P25800
QDKYRYCESRRRVLL	ARIH1	526	Q9Y4X5
DITRYYLCLQLRADI	EPB41L1	186	Q9H4G0
RLHICLYYREILVKE	IRF4	251	Q15306
LEACIYRLLKLYCRE	FDPS	201	P14324
RIYRSLAKILRYVDL	ASB17	46	Q8WXJ9
LLLYRERRLSYQSLC	GPR137C	71	Q8N3F9
YLLGIKRLRRLYCNV	FGF4	76	P08620
CLELLRKRDYEGYLC	NDUFAF6	61	Q330K2
SRFLRKAECIVRLYD	ECEL1	641	O95672
RSRKLDKLYEACRYL	CDC16	61	Q13042
TLKRRLECSLKVYLY	DCLRE1C	46	Q96SD1
IRYLYKLRDLHRDCE	DOCK5	1241	Q9H7D0
KKLCSFRYRRDLLRL	ADAR	1166	P55265
ERLLEYSRRCFLALD	CCDC106	241	Q9BWC9
RQLLCLIDYYESKIR	CEP70	211	Q8NHQ1
CLDILEDYLIQRRYT	CHD6	811	Q8TD26
RILYVLTYFLRCSEL	FNIP2	516	Q9P278
ELRRYTYLAKAVLRR	KRBOX1	96	C9JBD0
YRYTCRTLFERHKLL	DNAH2	3671	Q9P225
IRTDPDYIKRLRYCE	RUBCN	726	Q92622
RYPCKILLKSRYDVR	CFAP47	2291	Q6ZTR5
RRLAVYCLKDAYLPL	POLD1	506	P28340
YCLKDAYLPLRLLER	POLD1	511	P28340
LSEDITRYYLCLQLR	EPB41L3	196	Q9Y2J2
LYYVTRDDLKCLRLR	MAP3K5	1341	Q99683
VDQRKCERLLLYLYC	TRIM33	961	Q9UPN9
RLERYDECLAVYRDL	SRP72	121	O76094
RDLLRSLYDCDLYFL	CHST1	121	O43916
RRRREYCKFALLLVL	CHST7	6	Q9NS84
ILKRRYYRQHCTLEL	CTDNEP1	151	O95476
ITLYDIRAELSCRYK	SUPT6H	1121	Q7KZ85
PRDIYCRLKRHLEYV	TRABD2A	116	Q86V40
LLCYATASLRKLRAY	PIEZO1	321	Q92508
YVIRYLCKLSDQELR	USP34	271	Q70CQ2
YLCLSRYIGDSKILR	LGI3	436	Q8N145
CYYSVSLRKAERLRA	MYORG	76	Q6NSJ0