Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	serine-type endopeptidase activity	CLPP PRTN3 PRSS22 KLK14 ELANE KLK1	2.97e-05	190	63	6	GO:0004252
GeneOntologyMolecularFunction	serine-type peptidase activity	CLPP PRTN3 PRSS22 KLK14 ELANE KLK1	4.80e-05	207	63	6	GO:0008236
GeneOntologyMolecularFunction	serine hydrolase activity	CLPP PRTN3 PRSS22 KLK14 ELANE KLK1	5.48e-05	212	63	6	GO:0017171
GeneOntologyMolecularFunction	syndecan binding	NF1 CHRD	3.48e-04	9	63	2	GO:0045545
GeneOntologyCellularComponent	receptor complex	TAOK2 IL10RB TRBV5-7 TRBV5-6 TRBV5-4 TRBV5-3 BIRC2 ITGA5 GPRC5B	1.06e-04	581	68	9	GO:0043235
GeneOntologyCellularComponent	plasma membrane signaling receptor complex	IL10RB TRBV5-7 TRBV5-6 TRBV5-4 TRBV5-3 BIRC2 ITGA5	1.40e-04	350	68	7	GO:0098802
GeneOntologyCellularComponent	plasma membrane protein complex	IL10RB HLA-E TRBV5-7 TRBV5-6 KCNAB2 TRBV5-4 TRBV5-3 KCNAB1 BIRC2 ITGA5	2.13e-04	785	68	10	GO:0098797
GeneOntologyCellularComponent	azurophil granule lumen	MPO PRTN3 GUSB ELANE	2.21e-04	91	68	4	GO:0035578
GeneOntologyCellularComponent	side of membrane	JAK3 CD163L1 GAS1 HLA-E KCNAB2 KCNAB1 BIRC2 ITGA5 S1PR1 CD163	5.04e-04	875	68	10	GO:0098552
GeneOntologyCellularComponent	juxtaparanode region of axon	KCNAB2 KCNAB1	6.74e-04	12	68	2	GO:0044224
GeneOntologyCellularComponent	phagocytic vesicle	MPO HLA-E ELANE DMBT1	1.72e-03	157	68	4	GO:0045335
GeneOntologyCellularComponent	azurophil granule	MPO PRTN3 GUSB ELANE	1.84e-03	160	68	4	GO:0042582
GeneOntologyCellularComponent	primary lysosome	MPO PRTN3 GUSB ELANE	1.84e-03	160	68	4	GO:0005766
GeneOntologyCellularComponent	T cell receptor complex	TRBV5-7 TRBV5-6 TRBV5-4 TRBV5-3	1.97e-03	163	68	4	GO:0042101
GeneOntologyCellularComponent	vacuolar lumen	MPO PRTN3 GUSB ELANE	2.71e-03	178	68	4	GO:0005775
GeneOntologyCellularComponent	cell surface	EPHB2 MRC2 CD163L1 HLA-E CHRD ELANE ITGA5 S1PR1 CD163 GPRC5B	3.03e-03	1111	68	10	GO:0009986
GeneOntologyCellularComponent	cytoplasmic side of plasma membrane	JAK3 KCNAB2 KCNAB1 BIRC2	3.11e-03	185	68	4	GO:0009898
Domain	TRYPSIN_SER	PRTN3 PRSS22 KLK14 ELANE KLK1	1.53e-05	90	65	5	IPR033116
Domain	TRYPSIN_HIS	PRTN3 PRSS22 KLK14 ELANE KLK1	2.94e-05	103	65	5	IPR018114
Domain	TRYPSIN_SER	PRTN3 PRSS22 KLK14 ELANE KLK1	3.37e-05	106	65	5	PS00135
Domain	TRYPSIN_HIS	PRTN3 PRSS22 KLK14 ELANE KLK1	3.53e-05	107	65	5	PS00134
Domain	K_chnl_volt-dep_bsu_KCNAB-rel	KCNAB2 KCNAB1	3.57e-05	3	65	2	IPR005399
Domain	K_chnl_volt-dep_bsu_KCNAB	KCNAB2 KCNAB1	3.57e-05	3	65	2	IPR005983
Domain	Peptidase_S1A	PRTN3 PRSS22 KLK14 ELANE KLK1	4.59e-05	113	65	5	IPR001314
Domain	TRYPSIN_DOM	PRTN3 PRSS22 KLK14 ELANE KLK1	4.99e-05	115	65	5	PS50240
Domain	SRCR	CD163L1 DMBT1 CD163	5.12e-05	21	65	3	PF00530
Domain	Tryp_SPc	PRTN3 PRSS22 KLK14 ELANE KLK1	5.42e-05	117	65	5	SM00020
Domain	Trypsin	PRTN3 PRSS22 KLK14 ELANE KLK1	6.36e-05	121	65	5	PF00089
Domain	Trypsin_dom	PRTN3 PRSS22 KLK14 ELANE KLK1	6.36e-05	121	65	5	IPR001254
Domain	Peptidase_S1_PA	PRTN3 PRSS22 KLK14 ELANE KLK1	6.88e-05	123	65	5	IPR009003
Domain	SR	CD163L1 DMBT1 CD163	8.76e-05	25	65	3	SM00202
Domain	-	CD163L1 DMBT1 CD163	8.76e-05	25	65	3	3.10.250.10
Domain	SRCR_1	CD163L1 DMBT1 CD163	9.88e-05	26	65	3	PS00420
Domain	SRCR_2	CD163L1 DMBT1 CD163	9.88e-05	26	65	3	PS50287
Domain	SRCR-like_dom	CD163L1 DMBT1 CD163	9.88e-05	26	65	3	IPR017448
Domain	SRCR	CD163L1 DMBT1 CD163	1.11e-04	27	65	3	IPR001190
Domain	NUT	NUTM2F NUTM2G	1.18e-04	5	65	2	IPR024310
Domain	NUT_N	NUTM2F NUTM2G	1.18e-04	5	65	2	IPR024309
Domain	NUT	NUTM2F NUTM2G	1.18e-04	5	65	2	PF12881
Domain	-	KCNAB2 KCNAB1	1.39e-03	16	65	2	3.20.20.100
Domain	NADP_OxRdtase_dom	KCNAB2 KCNAB1	1.57e-03	17	65	2	IPR023210
Domain	Aldo_ket_red	KCNAB2 KCNAB1	1.57e-03	17	65	2	PF00248
Domain	Aldo/ket_red/Kv-b	KCNAB2 KCNAB1	1.57e-03	17	65	2	IPR001395
Domain	-	BIRC2 DAPK1 NLRC4	4.18e-03	93	65	3	1.10.533.10
Domain	CARD	BIRC2 NLRC4	4.25e-03	28	65	2	PF00619
Domain	Aden_trnslctor	SLC25A15 SLC25A48	4.25e-03	28	65	2	IPR002113
Domain	DEATH-like_dom	BIRC2 DAPK1 NLRC4	4.97e-03	99	65	3	IPR011029
Domain	CARD	BIRC2 NLRC4	5.20e-03	31	65	2	IPR001315
Domain	CARD	BIRC2 NLRC4	5.87e-03	33	65	2	PS50209
Pathway	KEGG_MEDICUS_VARIANT_TEL_AML1_FUSION_TO_TRANSCRIPTIONAL_REPRESSION	MPO ELANE SIN3A	9.07e-06	11	55	3	M47438
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	IGSF8 EPHB2 VMP1 NCAPD3 SCAP NF1 GUSB MRC2 GAS1 HLA-E PTDSS1 ITGA5 SLC4A2	5.97e-07	1201	69	13	35696571
Pubmed	Histone modification signature at myeloperoxidase and proteinase 3 in patients with anti-neutrophil cytoplasmic autoantibody-associated vasculitis.	MPO PRTN3	3.88e-06	2	69	2	27752292
Pubmed	Anti-PR3 and anti-MPO antibodies are not present in sera of patients with pulmonary tuberculosis.	MPO PRTN3	3.88e-06	2	69	2	24719228
Pubmed	Shaker K+ channel beta subunits belong to an NAD(P)H-dependent oxidoreductase superfamily.	KCNAB2 KCNAB1	3.88e-06	2	69	2	8001150
Pubmed	Compared action of neutrophil proteinase 3 and elastase on model substrates. Favorable effect of S'-P' interactions on proteinase 3 catalysts.	PRTN3 ELANE	3.88e-06	2	69	2	12538645
Pubmed	Myocardial Blood Flow Control by Oxygen Sensing Vascular Kvβ Proteins.	KCNAB2 KCNAB1	3.88e-06	2	69	2	33499656
Pubmed	Genetic modifiers of the Kv beta2-null phenotype in mice.	KCNAB2 KCNAB1	3.88e-06	2	69	2	15720404
Pubmed	High PR3 or ELA2 expression by CD34+ cells in advanced-phase chronic myeloid leukemia is associated with improved outcome following allogeneic stem cell transplantation and may improve PR1 peptide-driven graft-versus-leukemia effects.	PRTN3 ELANE	3.88e-06	2	69	2	17412886
Pubmed	Structures of human proteinase 3 and neutrophil elastase--so similar yet so different.	PRTN3 ELANE	3.88e-06	2	69	2	20423453
Pubmed	A large-scale transcriptome analysis identified ELANE and PRTN3 as novel methylation prognostic signatures for clear cell renal cell carcinoma.	PRTN3 ELANE	3.88e-06	2	69	2	31490025
Pubmed	Development and validation of a lateral flow assay (LFA) for the determination of IgG-antibodies to Pr3 (cANCA) and MPO (pANCA).	MPO PRTN3	3.88e-06	2	69	2	24291125
Pubmed	Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps.	MPO ELANE	3.88e-06	2	69	2	20974816
Pubmed	Survival and tumorigenesis in O6-methylguanine DNA methyltransferase-deficient mice following cyclophosphamide exposure.	NF1 MGMT	3.88e-06	2	69	2	18477655
Pubmed	NETosis-associated serum biomarkers are reduced in type 1 diabetes in association with neutrophil count.	PRTN3 ELANE	3.88e-06	2	69	2	26939803
Pubmed	Localization of two potassium channel beta subunit genes, KCNA1B and KCNA2B.	KCNAB2 KCNAB1	3.88e-06	2	69	2	8838324
Pubmed	Antineutrophil cytoplasmic antibody (ANCA) testing of routine sera varies in different laboratories but concordance is greater for cytoplasmic fluorescence (C-ANCA) and myeloperoxidase specificity (MPO-ANCA).	MPO PRTN3	3.88e-06	2	69	2	19490915
Pubmed	Assignment of CD163B, the gene encoding M160, a novel scavenger receptor, to human chromosome 12p13.3 by in situ hybridization and somatic cell hybrid analysis.	CD163L1 CD163	3.88e-06	2	69	2	11124526
Pubmed	Differences in the substrate binding sites of murine and human proteinase 3 and neutrophil elastase.	PRTN3 ELANE	3.88e-06	2	69	2	18023421
Pubmed	Expression of neutrophil elastase and myeloperoxidase mRNA in patients with newly diagnosed type 2 diabetes mellitus.	MPO ELANE	3.88e-06	2	69	2	31991297
Pubmed	Differences between human proteinase 3 and neutrophil elastase and their murine homologues are relevant for murine model experiments.	PRTN3 ELANE	3.88e-06	2	69	2	16182289
Pubmed	Immunopathogenesis of ANCA-Associated Vasculitis.	MPO PRTN3	3.88e-06	2	69	2	33023023
Pubmed	Proteinase 3 Autoreactivity in Anti-Neutrophil Cytoplasmic Antibody-associated vasculitis-Immunological versus clinical features.	MPO PRTN3	3.88e-06	2	69	2	32794199
Pubmed	Elevated first-trimester neutrophil elastase and proteinase 3 increase the risk of gestational diabetes mellitus and adverse fetal outcomes.	PRTN3 ELANE	3.88e-06	2	69	2	38167145
Pubmed	Neutrophil elastase and proteinase 3 trafficking routes in myelomonocytic cells.	PRTN3 ELANE	3.88e-06	2	69	2	20828556
Pubmed	Investigation of MGMT and DAPK1 methylation patterns in diffuse large B-cell lymphoma using allelic MSP-pyrosequencing.	MGMT DAPK1	3.88e-06	2	69	2	24071855
Pubmed	Identification of methylation markers for the prediction of nodal metastasis in oral and oropharyngeal squamous cell carcinoma.	MGMT DAPK1	3.88e-06	2	69	2	26213212
Pubmed	Potent and Broad but not Unselective Cleavage of Cytokines and Chemokines by Human Neutrophil Elastase and Proteinase 3.	PRTN3 ELANE	3.88e-06	2	69	2	31963828
Pubmed	Clinical and prognostic features of Korean patients with MPO-ANCA, PR3-ANCA and ANCA-negative vasculitis.	MPO PRTN3	3.88e-06	2	69	2	28339364
Pubmed	Gene-Specific DNA Methylation Changes Predict Remission in Patients with ANCA-Associated Vasculitis.	MPO PRTN3	3.88e-06	2	69	2	27821628
Pubmed	Influence of charge distribution at the active site surface on the substrate specificity of human neutrophil protease 3 and elastase. A kinetic and molecular modeling analysis.	PRTN3 ELANE	3.88e-06	2	69	2	17088257
Pubmed	Neutrophil activation precedes myocardial injury in patients with acute myocardial infarction.	MPO ELANE	3.88e-06	2	69	2	19362143
Pubmed	Proteinase 3 and neutrophil elastase enhance inflammation in mice by inactivating antiinflammatory progranulin.	PRTN3 ELANE	3.88e-06	2	69	2	18568075
Pubmed	Advanced Glycated End Products Alter Neutrophil Effect on Regulation of CD4+ T Cell Differentiation Through Induction of Myeloperoxidase and Neutrophil Elastase Activities.	MPO ELANE	3.88e-06	2	69	2	30343390
Pubmed	Genomic organization and chromosomal localization of mouse proteinase 3 (Myeloblastin).	PRTN3 ELANE	3.88e-06	2	69	2	10051312
Pubmed	A new proteinase 3 substrate with improved selectivity over human neutrophil elastase.	PRTN3 ELANE	3.88e-06	2	69	2	23911525
Pubmed	Hypertrophic pachymeningitis: significance of myeloperoxidase anti-neutrophil cytoplasmic antibody.	MPO PRTN3	3.88e-06	2	69	2	24271323
Pubmed	Neutrophil elastase and myeloperoxidase mRNA expression in overweight and obese subjects.	MPO ELANE	3.88e-06	2	69	2	30056589
Pubmed	Characterization and localization of the genes for mouse proteinase-3 (Prtn3) and neutrophil elastase (Ela2).	PRTN3 ELANE	3.88e-06	2	69	2	9925946
Pubmed	Myeloperoxidase plays critical roles in killing Klebsiella pneumoniae and inactivating neutrophil elastase: effects on host defense.	MPO ELANE	3.88e-06	2	69	2	15661916
Pubmed	Natural autoantibodies to myeloperoxidase, proteinase 3, and the glomerular basement membrane are present in normal individuals.	MPO PRTN3	3.88e-06	2	69	2	20592714
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	IGSF8 PKMYT1 EPHB2 VMP1 NCAPD3 MRC2 AHCTF1 PTDSS1 SIN3A ITGA5 HERC4 TPI1	3.97e-06	1203	69	12	29180619
Pubmed	Interaction proteomics of canonical Caspr2 (CNTNAP2) reveals the presence of two Caspr2 isoforms with overlapping interactomes.	KCNAB2 KCNAB1 TPI1	9.69e-06	21	69	3	25707359
Pubmed	Population-based case-control study on DAPK1, RAR-β2 and MGMT methylation in liquid-based cytology.	MGMT DAPK1	1.16e-05	3	69	2	22116316
Pubmed	Unopposed cathepsin G, neutrophil elastase, and proteinase 3 cause severe lung damage and emphysema.	PRTN3 ELANE	1.16e-05	3	69	2	24929239
Pubmed	Developmental expression of voltage-gated potassium channel beta subunits.	KCNAB2 KCNAB1	1.16e-05	3	69	2	10536234
Pubmed	Inflammation. Neutrophil extracellular traps license macrophages for cytokine production in atherosclerosis.	PRTN3 ELANE	1.16e-05	3	69	2	26185250
Pubmed	Increased neutrophil elastase and proteinase 3 and augmented NETosis are closely associated with β-cell autoimmunity in patients with type 1 diabetes.	PRTN3 ELANE	1.16e-05	3	69	2	25092677
Pubmed	Gas1 is induced during and participates in excitotoxic neuronal death.	GAS1 BIRC2	1.16e-05	3	69	2	11906213
Pubmed	PR3-ANCA-associated vasculitis is associated with a specific motif in the peptide-binding cleft of HLA-DP molecules.	MPO PRTN3	1.16e-05	3	69	2	30938436
Pubmed	Local structural plasticity of the Staphylococcus aureus evasion protein EapH1 enables engagement with multiple neutrophil serine proteases.	PRTN3 ELANE	1.16e-05	3	69	2	32303641
Pubmed	[The role of lung cancer related gene methylation in the early diagnosis of lung cancer].	MGMT DAPK1	1.16e-05	3	69	2	32867455
Pubmed	Cooperation between integrin alpha5 and tetraspan TM4SF5 regulates VEGF-mediated angiogenic activity.	TM4SF5 ITGA5	1.16e-05	3	69	2	19036703
Pubmed	Pulmonary proteases in the cystic fibrosis lung induce interleukin 8 expression from bronchial epithelial cells via a heme/meprin/epidermal growth factor receptor/Toll-like receptor pathway.	PRTN3 ELANE	1.16e-05	3	69	2	21193404
Pubmed	Three human elastase-like genes coordinately expressed in the myelomonocyte lineage are organized as a single genetic locus on 19pter.	PRTN3 ELANE	1.16e-05	3	69	2	1518849
Pubmed	Long non-coding RNA CRNDE promotes gallbladder carcinoma carcinogenesis and as a scaffold of DMBT1 and C-IAP1 complexes to activating PI3K-AKT pathway.	BIRC2 DMBT1	1.16e-05	3	69	2	27637083
Pubmed	Alternative splicing of the human Shaker K+ channel beta 1 gene and functional expression of the beta 2 gene product.	KCNAB2 KCNAB1	1.16e-05	3	69	2	7649300
Pubmed	Neutrophil elastase and proteinase-3 trigger G protein-biased signaling through proteinase-activated receptor-1 (PAR1).	PRTN3 ELANE	1.16e-05	3	69	2	24052258
Pubmed	Gene methylation profile of gastric cancerous tissue according to tumor site in the stomach.	MGMT DAPK1	1.16e-05	3	69	2	26810771
Pubmed	Structural characterization of mouse neutrophil serine proteases and identification of their substrate specificities: relevance to mouse models of human inflammatory diseases.	PRTN3 ELANE	1.16e-05	3	69	2	19833730
Pubmed	Azacytidine inhibits the proliferation of human promyelocytic leukemia cells (HL60) by demethylation of MGMT, DAPK and p16 genes.	MGMT DAPK1	1.16e-05	3	69	2	22549447
Pubmed	DAPK1, MGMT and RARB promoter methylation as biomarkers for high-grade cervical lesions.	MGMT DAPK1	1.16e-05	3	69	2	26823825
Pubmed	Selective interaction of voltage-gated K+ channel beta-subunits with alpha-subunits.	KCNAB2 KCNAB1	1.16e-05	3	69	2	8636142
Pubmed	Prognostic significance of epigenetic inactivation of p16, p15, MGMT and DAPK genes in follicular lymphoma.	MGMT DAPK1	2.32e-05	4	69	2	23275143
Pubmed	Isolation and preliminary characterization of the human and mouse homologues of the bacterial cell cycle gene era.	MPO NF1	2.32e-05	4	69	2	10945472
Pubmed	A potential role for multiple tissue kallikrein serine proteases in epidermal desquamation.	KLK14 KLK1	2.32e-05	4	69	2	17158887
Pubmed	A new K+ channel beta subunit to specifically enhance Kv2.2 (CDRK) expression.	KCNAB2 KCNAB1	2.32e-05	4	69	2	8824288
Pubmed	Neutrophil serine proteases promote IL-1β generation and injury in necrotizing crescentic glomerulonephritis.	MPO ELANE	2.32e-05	4	69	2	22241891
Pubmed	Promoter hypermethylation of CDKN2A, MGMT, MLH1, and DAPK genes in laryngeal squamous cell carcinoma and their associations with clinical profiles of the patients.	MGMT DAPK1	2.32e-05	4	69	2	23804521
Pubmed	Attenuated kinin release from human neutrophil elastase-pretreated kininogens by tissue and plasma kallikreins.	ELANE KLK1	2.32e-05	4	69	2	12887060
Pubmed	Smoking and matrix metalloproteinases, neutrophil elastase and myeloperoxidase in chronic periodontitis.	MPO ELANE	2.32e-05	4	69	2	20646231
Pubmed	Cutting edge: IL-1β processing during Pseudomonas aeruginosa infection is mediated by neutrophil serine proteases and is independent of NLRC4 and caspase-1.	ELANE NLRC4	2.32e-05	4	69	2	23024281
Pubmed	Genomic structure and chromosomal localization of the murine LIM class homeobox gene Lhx1.	MPO NF1	2.32e-05	4	69	2	9434953
Pubmed	Accessory Kvbeta1 subunits differentially modulate the functional expression of voltage-gated K+ channels in mouse ventricular myocytes.	KCNAB2 KCNAB1	2.32e-05	4	69	2	15662035
Pubmed	Human cathelicidin, hCAP-18, is processed to the antimicrobial peptide LL-37 by extracellular cleavage with proteinase 3.	PRTN3 ELANE	2.32e-05	4	69	2	11389039
Pubmed	Promoter methylation of DAPK1, FHIT, MGMT, and CDKN2A genes in cervical carcinoma.	MGMT DAPK1	2.32e-05	4	69	2	23494221
Pubmed	Promoter hypermethylation of multiple genes in early gastric adenocarcinoma and precancerous lesions.	MGMT DAPK1	2.32e-05	4	69	2	19695681
Pubmed	Human neutrophils secrete bioactive paucimannosidic proteins from azurophilic granules into pathogen-infected sputum.	MPO GUSB ELANE	3.23e-05	31	69	3	25645918
Pubmed	Use of RDA analysis of knockout mice to identify myeloid genes regulated in vivo by PU.1 and C/EBPalpha.	MPO PRTN3 ELANE	3.56e-05	32	69	3	9611252
Pubmed	Characterization of four murine homologs of the human ov-serpin monocyte neutrophil elastase inhibitor MNEI (SERPINB1).	PRTN3 ELANE	3.86e-05	5	69	2	12189154
Pubmed	Frequent intra-tumoural heterogeneity of promoter hypermethylation in malignant melanoma.	MGMT DAPK1	3.86e-05	5	69	2	17523078
Pubmed	Novel effects of neutrophil-derived proteinase 3 and elastase on the vascular endothelium involve in vivo cleavage of NF-kappaB and proapoptotic changes in JNK, ERK, and p38 MAPK signaling pathways.	PRTN3 ELANE	3.86e-05	5	69	2	12444202
Pubmed	Discriminating between the activities of human neutrophil elastase and proteinase 3 using serpin-derived fluorogenic substrates.	PRTN3 ELANE	3.86e-05	5	69	2	12114510
Pubmed	Mice Deficient in the IL-1β Activation Genes Prtn3, Elane, and Casp1 Are Protected Against the Development of Obesity-Induced NAFLD.	PRTN3 ELANE	3.86e-05	5	69	2	32002713
Pubmed	The complete 685-kilobase DNA sequence of the human beta T cell receptor locus.	TRBV5-7 TRBV5-6 TRBV5-4 TRBV5-3	3.94e-05	95	69	4	8650574
Pubmed	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.	EPHB2 IL10RB VMP1 NCAPD3 SCAP NF1 GUSB MRC2 HLA-E SLC4A2	4.45e-05	1061	69	10	33845483
Pubmed	Differential stimulation of PKC phosphorylation of potassium channels by ZIP1 and ZIP2.	KCNAB2 KCNAB1	5.79e-05	6	69	2	10477520
Pubmed	The NLRP3/ASC/Caspase-1 axis regulates IL-1β processing in neutrophils.	PRTN3 ELANE	5.79e-05	6	69	2	22213227
Pubmed	Gene methylation of SFRP2, P16, DAPK1, HIC1, and MGMT and KRAS mutations in sporadic colorectal cancer.	MGMT DAPK1	5.79e-05	6	69	2	20682398
Pubmed	Promoter methylation of TIMP3 and CDH1 predicts better outcome in head and neck squamous cell carcinoma treated by radiotherapy only.	MGMT DAPK1	5.79e-05	6	69	2	19148529
Pubmed	Cloning and characterization of hurpin (protease inhibitor 13): A new skin-specific, UV-repressible serine proteinase inhibitor of the ovalbumin serpin family.	PRTN3 ELANE	5.79e-05	6	69	2	10512713
Pubmed	A single cyclin A gene and multiple cyclin B1-related sequences are dispersed in the mouse genome.	GUSB MECOM KLK1	6.49e-05	39	69	3	1535334
Pubmed	Pyroptosis triggers pore-induced intracellular traps (PITs) that capture bacteria and lead to their clearance by efferocytosis.	MPO ELANE	8.09e-05	7	69	2	27573815
Pubmed	Glutathione S-transferase P1 and NADPH quinone oxidoreductase polymorphisms are associated with aberrant promoter methylation of P16(INK4a) and O(6)-methylguanine-DNA methyltransferase in sputum.	MPO MGMT	8.09e-05	7	69	2	11956078
Pubmed	Nucleotide sequence analysis of 77.7 kb of the human V beta T-cell receptor gene locus: direct primer-walking using cosmid template DNAs.	TRBV5-6 TRBV5-4	8.09e-05	7	69	2	8020962
Pubmed	Killing activity of neutrophils is mediated through activation of proteases by K+ flux.	MPO ELANE	8.09e-05	7	69	2	11907569
Pubmed	A novel chemokine, macrophage inflammatory protein-related protein-2, inhibits colony formation of bone marrow myeloid progenitors.	MPO NF1	8.09e-05	7	69	2	7650394
Pubmed	The elimination of Anaplasma phagocytophilum requires CD4+ T cells, but is independent of Th1 cytokines and a wide spectrum of effector mechanisms.	MPO ELANE	1.08e-04	8	69	2	19039769
Pubmed	Human chromosome 17 comparative anchor loci are conserved on bovine chromosome 19.	MPO NF1	1.08e-04	8	69	2	7557995
Pubmed	Antibiotic proteins of human polymorphonuclear leukocytes.	PRTN3 ELANE	1.08e-04	8	69	2	2501794
Pubmed	Cloning and expression analysis of murine phospholipase D1.	NF1 MECOM	1.08e-04	8	69	2	9307024
Cytoband	7q34	TRBV5-7 TRBV5-6 TRBV5-4 TRBV5-3	1.21e-04	167	69	4	7q34
Cytoband	Ensembl 112 genes in cytogenetic band chr7q34	TRBV5-7 TRBV5-6 TRBV5-4 TRBV5-3	1.80e-04	185	69	4	chr7q34
Cytoband	17q23.1	MPO VMP1	2.64e-04	16	69	2	17q23.1
Cytoband	16p13.3	PKMYT1 C16orf90 PRSS22 CLDN9	5.13e-04	244	69	4	16p13.3
Cytoband	12p13.3	CD163L1 CD163	9.42e-04	30	69	2	12p13.3
Cytoband	Ensembl 112 genes in cytogenetic band chr9q21	GAS1 DAPK1 CARNMT1	3.41e-03	199	69	3	chr9q21
Cytoband	Ensembl 112 genes in cytogenetic band chr16p13	PKMYT1 C16orf90 PRSS22 CLDN9	3.93e-03	426	69	4	chr16p13
GeneFamily	T cell receptor beta locus at 7q34	TRBV5-7 TRBV5-6 TRBV5-4 TRBV5-3	5.86e-05	87	44	4	372
GeneFamily	ADAM metallopeptidase domain containing\|CD molecules	IGSF8 IL10RB MRC2 ITGA5 S1PR1 CD163	3.61e-04	394	44	6	471
GeneFamily	Potassium voltage-gated channel regulatory subunits\|DASH family	KCNAB2 KCNAB1	5.96e-04	15	44	2	858
GeneFamily	Aldo-keto reductases	KCNAB2 KCNAB1	5.96e-04	15	44	2	399
GeneFamily	Kallikreins	KLK14 KLK1	6.80e-04	16	44	2	616
GeneFamily	C2-set domain containing\|Immunoglobulin like domain containing\|Scavenger receptors	CD163L1 CD163	1.95e-03	27	44	2	1253
GeneFamily	WD repeat domain containing\|Caspase recruitment domain containing\|Apoptosome	BIRC2 NLRC4	2.41e-03	30	44	2	959
Coexpression	HAY_BONE_MARROW_CD34_POS_GRAN	MPO GPR12 PRTN3 ELANE	6.95e-07	27	68	4	M39181
Coexpression	GSE8921_UNSTIM_VS_TLR1_2_STIM_MONOCYTE_24H_DN	MPO PRTN3 GUSB KCNAB2 DAPK1 ITGA5	1.35e-05	200	68	6	M6421
Coexpression	DESCARTES_FETAL_HEART_MYELOID_CELLS	MPO PRTN3 CD163L1 NLRC4 CD163	2.80e-05	136	68	5	M40196
Coexpression	LIAN_NEUTROPHIL_GRANULE_CONSTITUENTS	MPO GUSB ELANE	3.69e-05	25	68	3	M1478
Coexpression	LIAN_NEUTROPHIL_GRANULE_CONSTITUENTS	MPO GUSB ELANE	4.16e-05	26	68	3	MM639
Coexpression	JACKSON_DNMT1_TARGETS_UP	IL10RB GPR12 HLA-E SIN3A	6.84e-05	84	68	4	M1604
Coexpression	WANG_IMMORTALIZED_BY_HOXA9_AND_MEIS1_UP	MPO PRTN3 ELANE	7.85e-05	32	68	3	M1450
Coexpression	MILI_PSEUDOPODIA_HAPTOTAXIS_DN	IGSF8 PKMYT1 EPHB2 GUSB MRC2 HLA-E ITGA5 CLDN9 GPRC5B	8.19e-05	703	68	9	MM1055
Coexpression	DESCARTES_FETAL_LUNG_MYELOID_CELLS	MPO PRTN3 CD163L1 NLRC4 CD163	1.01e-04	178	68	5	M40244
Coexpression	JACKSON_DNMT1_TARGETS_UP	IL10RB GPR12 HLA-E SIN3A	1.02e-04	93	68	4	MM1185
Coexpression	DESCARTES_FETAL_LIVER_HEMATOPOIETIC_STEM_CELLS	MPO PRTN3 CPNE7	1.12e-04	36	68	3	M40236
Coexpression	WANG_IMMORTALIZED_BY_HOXA9_AND_MEIS1_UP	MPO PRTN3 ELANE	1.22e-04	37	68	3	MM630
ToppCell	facs-Lung-EPCAM-24m-Hematologic-Proliferating_Immune\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MPO PRTN3 MGMT PRSS22 ELANE SLC25A48	4.45e-07	186	69	6	9ce3bd121869215a4e6114a310f9d2fb5adaef61
ToppCell	facs-Lung-EPCAM-24m-Hematologic\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MPO PRTN3 MGMT PRSS22 ELANE SLC25A48	4.45e-07	186	69	6	18c40203463d4dd8558c04977d52e400a8268f90
ToppCell	facs-Lung-EPCAM-24m-Hematologic-leukocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MPO PRTN3 MGMT PRSS22 ELANE SLC25A48	4.45e-07	186	69	6	a7fd35eabcfb534019dfe5a8a600bf2ec47c1ac2
ToppCell	10x5'v1-week_17-19-Myeloid_neutrophil-granulo-neutrophil-promyelocyte\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	MPO JAK3 PRTN3 SLC25A15 ELANE	6.52e-06	169	69	5	f33f4a0baad1b3cb5be61dfc7b00c7a3845f7120
ToppCell	343B-Myeloid-Dendritic-cDC_proliferating_2\|343B / Donor, Lineage, Cell class and subclass (all cells)	PKMYT1 MPO PRTN3 ELANE CD163	7.51e-06	174	69	5	a75ba49ccea6bd3d78ada1092b46deb5202c58a5
ToppCell	facs-Marrow-KLS-18m-Myeloid\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PKMYT1 MPO PRTN3 GUSB ELANE	1.15e-05	190	69	5	c03c735a0ed850bf460a1847f5e2dd61753e577d
ToppCell	facs-Diaphragm\|facs / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MPO VMP1 PRTN3 SLC10A6 ELANE	1.21e-05	192	69	5	486cbf9791ca619e307e8b18aa70ce22111f4f26
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Endothelial-blood_vessel_EC-Fetal_arterial_EC\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PDE6G HLA-E MECOM S1PR1 GPRC5B	1.21e-05	192	69	5	5a0615fdc217554ccd611504b16e5d97628e207d
ToppCell	10x5'-GI_small-bowel-Myeloid_Mac-Intestinal_macrophages\|GI_small-bowel / Manually curated celltypes from each tissue	EPHB2 MRC2 CD163L1 DAPK1 CD163	1.34e-05	196	69	5	075e5746fa5cb121115a1d51b823c0fbf8d54305
ToppCell	3'_v3-bone_marrow-Hematopoietic_progenitors-HSC-MPP\|bone_marrow / Manually curated celltypes from each tissue	MPO GPR12 PRTN3 ELANE MECOM	1.34e-05	196	69	5	2440201ff08a88d7e4d92dd6e9ff4d0e271605eb
ToppCell	COVID-19_Severe-Classical_Monocyte\|World / disease group, cell group and cell class	EPHB2 MPO PRTN3 ELANE CD163	1.37e-05	197	69	5	344801997b89bd81d8d5c3c872934de523233a8d
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Endothelial-blood_vessel_EC-Fetal_arterial_EC\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PDE6G HLA-E MECOM ITGA5 S1PR1	1.44e-05	199	69	5	b15304d3d3f6c254969b54a61bee3d9f368840b2
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-Mono-Mono_hypoxia-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	KCNAB2 DAPK1 ITGA5 CD163 NUTM2G	1.44e-05	199	69	5	379bbd9cecf466b902411c54d74bd9885285b1ba
ToppCell	droplet-Pancreas-Exocrine-18m-Epithelial-pancreatic_acinar_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MPO ELANE DMBT1 KLK1	2.24e-05	106	69	4	c890c838785dfeda30f3b563194da9cfb49b157a
ToppCell	COVID_non-vent-Myeloid-Monocytic-Developing_Neutrophil\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	MPO PRTN3 ELANE NUTM2G	5.12e-05	131	69	4	5b29f0dc449b9fff5e8bf6365080168f31b7e268
ToppCell	10x5'-bone_marrow-Hematopoietic_progenitors-Progenitor\|bone_marrow / Manually curated celltypes from each tissue	PKMYT1 MPO PRTN3 ELANE	7.81e-05	146	69	4	035393166f3ad5ab95602a8ae11b7d0ee4b1d691
ToppCell	10x5'-bone_marrow-Lymphocytic_T_CD8-Trm_gut_CD8\|bone_marrow / Manually curated celltypes from each tissue	GAS1 PRSS22 KLK14 GPRC5B	9.60e-05	154	69	4	93145a1bc5712ae664690b03a9e00ce1f92cfc7e
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Lect1_Oxtr\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	GAS1 SLC10A6 DMBT1 CPNE7	9.84e-05	155	69	4	99e749f7075e2c64e9a0bf91009f95b6969197c8
ToppCell	facs-Brain_Myeloid-Cerebellum\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MPO PRTN3 ELANE CD163	1.01e-04	156	69	4	28c4fb4d2c6c47696c3a6722998f9da5a8923323
ToppCell	facs-Lung-24m\|Lung / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MPO MGMT PRSS22 ELANE	1.17e-04	162	69	4	4e418bea07e35038b32a78a1e6632b6ec1208cdc
ToppCell	3'_v3-GI_small-bowel-Lymphocytic_T_CD8-Tem/emra_CD8\|GI_small-bowel / Manually curated celltypes from each tissue	MPO PRTN3 ELANE MECOM	1.19e-04	163	69	4	1a8c79903ed416f286ebe8a9922233affbc55d82
ToppCell	356C-Myeloid-Macrophage-SPP1+_Macrophage\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	ZNF776 PDE6G GAS1 KCNAB1	1.22e-04	164	69	4	d6806deabf5f5c355934387be2baae125ac33fb8
ToppCell	facs-Spleen-nan-24m\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MPO PRTN3 MGMT ELANE	1.25e-04	165	69	4	966ed14d479e0f1a507f46d08408aa99bd7682ae
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Myeloid-Macrophage-macrophage,_alveolar\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CD163L1 MECOM DAPK1 CD163	1.28e-04	166	69	4	28a44448a0b0d72459e8fe84ce5d666f16f514b3
ToppCell	facs-Lung-24m-Hematologic-myeloid-interstitial_macrophage-interstitial_macrophage_l12\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	IGSF8 IL10RB PDE6G CD163	1.28e-04	166	69	4	7be2b5c62e2be3437ea50b9a473cf9fc7f05e0b1
ToppCell	facs-Lung-24m-Hematologic-myeloid-interstitial_macrophage\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	IGSF8 IL10RB PDE6G CD163	1.28e-04	166	69	4	8418b191e7f16cb39301df3ddbfb1bab6c0632d6
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Myeloid-Macrophage\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CD163L1 MECOM DAPK1 CD163	1.28e-04	166	69	4	2a04915d534a83e65aa168435d6856125b5bdd78
ToppCell	3'_v3-blood-Hematopoietic_progenitors-HSC-MPP\|blood / Manually curated celltypes from each tissue	MPO PRTN3 ELANE MECOM	1.40e-04	170	69	4	1443d7fccc81088dd42dcbb9361e269872542274
ToppCell	3'_v3-bone_marrow-Hematopoietic_progenitors-Progenitor_pre-Lymphocytic-T\|bone_marrow / Manually curated celltypes from each tissue	MPO PRTN3 ELANE MECOM	1.47e-04	172	69	4	a66402d15853f0c9e3d06394ff9ac08d1da128ff
ToppCell	PND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MPO GAS1 TM4SF5 KLK1	1.50e-04	173	69	4	ee7d1429f23f1b89a9a9f7bc07a84a44cf7acd1c
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Epithelial-neuro-epithelial\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	VWA5B2 PRSS22 TM4SF5 NUTM2G	1.50e-04	173	69	4	46ed379571385684145b5cb6dd4ae340ac546e64
ToppCell	droplet-Lung-LUNG-1m-Myeloid-Interstitial_Macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IGSF8 IL10RB TMEM144 CD163	1.50e-04	173	69	4	26bba58f9fb215d1d155504906cd77e8774f6936
ToppCell	droplet-Lung-LUNG-1m-Myeloid-lung_macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IGSF8 IL10RB TMEM144 CD163	1.50e-04	173	69	4	69b404e92aad3e6dff67e75466f073f20a71f13f
ToppCell	PND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MPO GAS1 TM4SF5 KLK1	1.50e-04	173	69	4	3725525b99a6011eda2ff5459b4fd2e1eab1f090
ToppCell	facs-Brain_Myeloid-Cerebellum-24m-Myeloid-microglial_cell\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MPO PRTN3 PRSS22 ELANE	1.50e-04	173	69	4	ef862e1d626bbc33191b433f483addff7f75ba16
ToppCell	3'_v3-bone_marrow-Hematopoietic_progenitors-Cycling_pre-Lymphocytic-T\|bone_marrow / Manually curated celltypes from each tissue	PKMYT1 MPO PRTN3 ELANE	1.54e-04	174	69	4	1e289b26e2c29dbad15b712a999b96c391a26129
ToppCell	3'_v3-lymph-node_spleen-Hematopoietic_progenitors\|lymph-node_spleen / Manually curated celltypes from each tissue	MPO PRTN3 ELANE MECOM	1.54e-04	174	69	4	6d9bdf4d28ff8ebb66ffd1ccdd6a4fe9440a83f3
ToppCell	droplet-Bladder-Unstain-18m-Hematologic-nan\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD163L1 KCNAB2 CD163 CPNE7	1.54e-04	174	69	4	773329bb91b97578df138446cf62101dd0dad758
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Hematopoietic-B_cells-CLP\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MPO JAK3 PRTN3 ELANE	1.60e-04	176	69	4	f163cc6d632112aad35a0a9217c6c99fbdd1386e
ToppCell	3'_v3-lymph-node_spleen-Hematopoietic_progenitors-HSC-MPP\|lymph-node_spleen / Manually curated celltypes from each tissue	MPO PRTN3 ELANE MECOM	1.60e-04	176	69	4	32ed5623b8809b9f1aaf7a42dff9807d9376e9c2
ToppCell	10x5'-lymph-node_spleen-Hematopoietic_progenitors-HSC-MPP\|lymph-node_spleen / Manually curated celltypes from each tissue	MPO PRTN3 ELANE MECOM	1.60e-04	176	69	4	de67ed15a50d2515ba6d152c1011a3367f77aedd
ToppCell	3'_v3-blood-Hematopoietic_progenitors\|blood / Manually curated celltypes from each tissue	MPO PRTN3 ELANE MECOM	1.64e-04	177	69	4	22c77077951889e63489abfabf90900655655c82
ToppCell	facs-Limb_Muscle-Muscle_Diaphragm-18m-Mesenchymal-skeletal_muscle_satellite_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MPO VMP1 PRTN3 ELANE	1.68e-04	178	69	4	56b19f9c9585538fb8a4c3eea2d132b254cf11ef
ToppCell	3'_v3-Lung-Hematopoietic_progenitors\|Lung / Manually curated celltypes from each tissue	MPO PRTN3 ELANE MECOM	1.68e-04	178	69	4	c7895ba2e2e93b26da91faa2a3bf9d070dd4c3bd
ToppCell	droplet-Spleen-SPLEEN-30m-Hematologic-proerythroblast\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MPO PRTN3 ELANE ITGA5	1.68e-04	178	69	4	be8af4d85b8835a85a168639c37857dcaa6b00bf
ToppCell	343B-Lymphocytic-NK_cells-Proliferating_NK_cell\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	TAOK2 PKMYT1 NCAPD3 SLC25A15	1.68e-04	178	69	4	c7e890cd02206c516cf1d7692ea7abc8ce746482
ToppCell	facs-Marrow-B-cells-18m-Myeloid-granulocyte_monocyte_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MPO NCAPD3 PRTN3 ELANE	1.71e-04	179	69	4	b88791dd4e73bb8410ca090938a1a45b0bc16e69
ToppCell	3'_v3-Lung-Hematopoietic_progenitors-HSC-MPP\|Lung / Manually curated celltypes from each tissue	MPO PRTN3 ELANE MECOM	1.71e-04	179	69	4	2c03b82ec9b4dee2501752b8d83e7028f0aaed77
ToppCell	PBMC-Severe-Myeloid-Neutrophil-immature_Neutrophil-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	PKMYT1 MPO PRTN3 ELANE	1.71e-04	179	69	4	e1bfd553c043ebc070ccf8545d489ba16d9b2ef4
ToppCell	facs-Marrow-B-cells-18m-Myeloid-granulocyte_monocyte_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MPO NCAPD3 PRTN3 ELANE	1.71e-04	179	69	4	c063028b82c68d929aef2421daade9dc189a6963
ToppCell	PND07-Immune-Immune_Myeloid-Monocytic-Macrophage-IM\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	IL10RB GUSB NLRC4 CD163	1.71e-04	179	69	4	fae869fb0a91428481bf8a9c111dcc639e2b4278
ToppCell	10x_3'_v3-spleen_(10x_3'_v3)-hematologic-hematopoietic_progenitor\|spleen_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	MPO PRTN3 ELANE MECOM	1.75e-04	180	69	4	f598bb9df0d784120847fada2d9a2a88b8b68cd1
ToppCell	10x_3'_v3-spleen_(10x_3'_v3)-hematologic-hematopoietic_progenitor-hematopoietic_stem_cell\|spleen_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	MPO PRTN3 ELANE MECOM	1.75e-04	180	69	4	b4fa047f271c7b56940bdc85c912f50aa5b5ca82
ToppCell	IIH-CD8-CD4_Treg\|IIH / Condition, Cell_class and T cell subcluster	TAOK2 KCNAB2 ZNF470 AHCYL2	1.75e-04	180	69	4	d1a8b25115c80e5a5bd0b8244167a98250ab9778
ToppCell	facs-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l17\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MRC2 GAS1 CHRD CPNE7	1.75e-04	180	69	4	39ae8586efd91536e9ac6408d26de7e6d6237c41
ToppCell	droplet-Pancreas-Exocrine-18m-Epithelial-nan\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ELANE DMBT1 KLK1	1.76e-04	70	69	3	26178ee967d647224d93c7a6380f2d15d8fcfb8f
ToppCell	5'-Adult-Appendix-Hematopoietic-Myeloid\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CD163L1 DAPK1 NLRC4 CD163	1.79e-04	181	69	4	79102845baee5af583eec24e9f91dfec46ab7de3
ToppCell	HSPCs-Mono_prog.\|World / Lineage and Cell class	MPO PRTN3 GUSB ELANE	1.86e-04	183	69	4	1b73070baa9e5d5ada4ce25a77741630af9c1a3a
ToppCell	wk_15-18-Epithelial-Proximal_epithelial-GHRL+_neuroendocrine\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	VWA5B2 GPR12 SOHLH1 CLDN9	1.86e-04	183	69	4	8820cfed27b292bc0bc9cde4005219ed41900552
ToppCell	3'_v3-lymph-node_spleen-Hematopoietic_progenitors-Progenitor_pre-Lymphocytic-T\|lymph-node_spleen / Manually curated celltypes from each tissue	MPO PRTN3 ELANE MECOM	1.86e-04	183	69	4	6c55fd737ed31f5b1aa41dc4dba7240521c19022
ToppCell	droplet-Lung-18m-Hematologic-myeloid-classical_monocyte_proliferating\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MPO PRTN3 ELANE CD163	1.86e-04	183	69	4	6c1d7ce60e67bf1df364a4e177c351e7313eb41f
ToppCell	E15.5-Mesenchymal-mesenchymal_fibroblast-mesothelial_cell_of_visceral_pleura\|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	GAS1 KLK14 TM4SF5 KCNAB1	1.86e-04	183	69	4	274f274cf60daa30d6a4cd603a3af7823bfb8016
ToppCell	3'-Child04-06-SmallIntestine-Hematopoietic-Myeloid-Macrophages\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CD163L1 DAPK1 NLRC4 CD163	1.86e-04	183	69	4	92d5a61b57851090eba558f19e2a7010043eff81
ToppCell	Control-Myeloid_G-immature_Neutrophil\|Control / Disease group, lineage and cell class	MPO PRTN3 KCNAB2 ELANE	1.90e-04	184	69	4	45f873236f7e90fb78c8e291d3b5b92d121acec9
ToppCell	3'_v3-lymph-node_spleen-Hematopoietic_progenitors-Cycling_pre-Myeloid-1\|lymph-node_spleen / Manually curated celltypes from each tissue	PKMYT1 MPO PRTN3 ELANE	1.90e-04	184	69	4	f93373fcde5c31f4ffe67ca0f3ea7f4e906dc88b
ToppCell	3'-Child09-12-SmallIntestine-Endothelial-blood_vessel_EC-Mature_arterial_EC\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MECOM ITGA5 S1PR1 GPRC5B	1.90e-04	184	69	4	842473fa415575441b595073a994b6d621169776
ToppCell	facs-Lung-24m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l17\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	EPHB2 SLC25A15 GAS1 CPNE7	1.90e-04	184	69	4	d754c3de621429b220ae4ac426cdfc619e848462
ToppCell	facs-Marrow-KLS-24m-Myeloid-granulocyte_monocyte_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLPP MPO PRTN3 ELANE	1.90e-04	184	69	4	4da04cb74d71fee80ae1d80877f0910718976fc7
ToppCell	facs-Marrow-KLS-24m-Myeloid-granulocyte_monocyte_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLPP MPO PRTN3 ELANE	1.90e-04	184	69	4	5243ca98097b246d5c22dc26c274dab9d593c82c
ToppCell	Mid-temporal_gyrus_(MTG)-Non-neuronal-Endothelial_Myeloid-Endo-Endothelial\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HLA-E MECOM ITGA5 S1PR1	1.94e-04	185	69	4	03df43e9c2ce4ec24ffed8e4e2993f94ba951c8b
ToppCell	droplet-Lung-21m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l17\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	EPHB2 GAS1 CHRD MECOM	1.94e-04	185	69	4	1b990e3089772be2b38c6d7ea0d1bf22461ae3ea
ToppCell	droplet-Kidney-KIDNEY-1m-Epithelial-kidney_loop_of_Henle_ascending_limb_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPHB2 GAS1 MECOM KLK1	1.94e-04	185	69	4	af86e75096c1812ae27a78405355957ee8043d84
ToppCell	Mid-temporal_gyrus_(MTG)-Non-neuronal-Endothelial_Myeloid-Endo-Endothelial-Endo_L2-5_CLDN5\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HLA-E MECOM ITGA5 S1PR1	1.94e-04	185	69	4	dbdbd6593cd98550238519746bb45fbf0617550b
ToppCell	Mid-temporal_gyrus_(MTG)-Non-neuronal-Endothelial_Myeloid-Endo\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HLA-E MECOM ITGA5 S1PR1	1.94e-04	185	69	4	de2c24719946d5a37a982d816776cea7f3984c49
ToppCell	droplet-Marrow-nan-18m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MPO PRTN3 ELANE TPI1	1.98e-04	186	69	4	1bb10a6625c0ada3fe0f0adf7b5899d299d2a9c0
ToppCell	primary_auditory_cortex_(A1C)-Non-neuronal-Endothelial_Myeloid-Endo-Endothelial\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HLA-E MECOM ITGA5 S1PR1	2.02e-04	187	69	4	698ae9eefa8ba97fea8ea61e4e868edd194de03b
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Endothelial-blood_vessel_EC\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HLA-E MECOM ITGA5 S1PR1	2.02e-04	187	69	4	0ef82111b9049cc7ee78d64d240e1f10ab14d6b6
ToppCell	primary_auditory_cortex_(A1C)-Non-neuronal-Endothelial_Myeloid-Endo\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HLA-E MECOM ITGA5 S1PR1	2.02e-04	187	69	4	ed8816433d1086a634892502898255b487a2d4a7
ToppCell	droplet-Lung-1m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l17\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	EPHB2 MRC2 GAS1 KCNAB1	2.02e-04	187	69	4	ed7ab4cf4629d96dad5c74d536fc428d0a8d4eb9
ToppCell	metastatic_Brain-Myeloid_cells-Alveolar_Mac\|Myeloid_cells / Location, Cell class and cell subclass	PRTN3 ELANE KCNAB1 KLK1	2.02e-04	187	69	4	7375f70a970a5d5a58b7c33ada2dcf6dcef525c6
ToppCell	primary_auditory_cortex_(A1C)-Non-neuronal-Endothelial_Myeloid-Endo-Endothelial-Endo_L2-5_CLDN5\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HLA-E MECOM ITGA5 S1PR1	2.02e-04	187	69	4	d8b09398400a178b03e641af1476c4dac0c6e82a
ToppCell	LPS-antiTNF-Endothelial-Endothelial-Alv_Gen_Intermediate\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TPK1 ITGA5 S1PR1 GPRC5B	2.06e-04	188	69	4	789d1be574e693d7bdd488f3c72c6df788e47b47
ToppCell	5'-GW_trimst-2-LargeIntestine-Endothelial-blood_vessel_EC-Fetal_arterial_EC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MECOM ITGA5 S1PR1 GPRC5B	2.11e-04	189	69	4	db09d591b885ce2bc9e353f08b6694e2192582e1
ToppCell	droplet-Kidney-nan-3m-Epithelial-kidney_distal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GAS1 MECOM DAPK1 KLK1	2.11e-04	189	69	4	e127e3be626bc513e151d41812f0b7adb89d5da6
ToppCell	droplet-Kidney-nan-3m-Epithelial-Epcam_____kidney_distal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GAS1 MECOM DAPK1 KLK1	2.11e-04	189	69	4	ff637ae0afdb1fdc67451be7e1e4fe575fbcfff4
ToppCell	COPD-Myeloid-ncMonocyte\|Myeloid / Disease state, Lineage and Cell class	JAK3 VMP1 AHCTF1 KCNAB2	2.15e-04	190	69	4	ed978cd5d9da87b49878a330e362762c487f849f
ToppCell	HSPCs-Gran/Mono_prog.\|World / Lineage and Cell class	MPO PRTN3 GUSB ELANE	2.15e-04	190	69	4	94547c1cc2c3f2ac28a6d07317e50e1e3fd20267
ToppCell	(2)_Fibroblasts-(21)_Fibro-2\|(2)_Fibroblasts / Cell class and subclass of bone marrow stroma cells in homeostatis	IGSF8 GUSB MRC2 GPRC5B	2.15e-04	190	69	4	d2afa08ad868acc6fce308ec21b0bf93591d4010
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-Mono-Mono_anti-infl-A\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	DAPK1 AHCYL2 HERC4 CD163	2.15e-04	190	69	4	63018acb7ad80415e861643162abdc2e55968ee4
ToppCell	PCW_07-8.5-Hematologic_Myeloid-Hem_Myeloid_macrophage-im_immature_macrophage2_(0)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	TMEM144 CD163L1 KCNAB1 CD163	2.15e-04	190	69	4	912aa106581d1ed7e147c92f9a367e8e6b04052b
ToppCell	10x_3'_v3-spleen_(10x_3'_v3)-myeloid-myeloid_monocytic-intermediate_monocyte\|spleen_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	MPO PRTN3 ELANE NLRC4	2.15e-04	190	69	4	896b5825edb30fe62cbbed6078570c1f8057a99e
ToppCell	droplet-Marrow-BM_(NON-STC)-30m-Lymphocytic-naive_T_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLPP MPO PRTN3 ELANE	2.15e-04	190	69	4	a1b5775a21d42633224b7d348f0d12b0589dad12
ToppCell	LV-08._Macrophage\|World / Chamber and Cluster_Paper	TPK1 CD163L1 DAPK1 CD163	2.19e-04	191	69	4	e7a0bc46ba9ba772636a583f3387748418e18832
ToppCell	human_hepatoblastoma-Inflammatory_Monocytes\|World / Sample and Cell Type and Tumor Cluster (all cells)	TPK1 CD163L1 KCNAB2 CD163	2.19e-04	191	69	4	3b59bfc6c106ae8a3fbcd4a74bd128c485724921
ToppCell	HSPCs-Gran/Mono_prog.\|HSPCs / Lineage and Cell class	MPO PRTN3 GUSB ELANE	2.19e-04	191	69	4	54620502e6aea0a615b664e861e0044dd9e0ad91
ToppCell	3'_v3-GI_small-bowel-Lymphocytic_T_CD4/8-lo-Cycling_T\|GI_small-bowel / Manually curated celltypes from each tissue	PKMYT1 MPO PRTN3 ELANE	2.19e-04	191	69	4	e642fa7395c05fb53324c9d46bbc52f89fc9673f
ToppCell	3'-Broncho-tracheal-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell-EC_arterial\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	HLA-E MECOM S1PR1 GPRC5B	2.19e-04	191	69	4	04c7aa2e39fdd08ca24c10d43b29a5e41a73b9e0
ToppCell	3'-Broncho-tracheal-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	HLA-E MECOM S1PR1 GPRC5B	2.19e-04	191	69	4	db8dd6bbba803585bdd6a55d5c403d383f2e9acf
ToppCell	10x5'-bone_marrow\|World / Manually curated celltypes from each tissue	PKMYT1 MPO PRTN3 ELANE	2.24e-04	192	69	4	34777fa7dc001b6d601376a23aab995e2cec043c
ToppCell	droplet-Kidney-nan-18m-Epithelial-Epcam_____kidney_distal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GAS1 MECOM DAPK1 KLK1	2.24e-04	192	69	4	6fb56d062c35617b18b927704bf5fba894faed81
Drug	Trifluridine [70-00-8]; Up 200; 13.6uM; MCF7; HT_HG-U133A	EPHB2 TMEM144 PRTN3 NF1 KCNAB2 KCNAB1 GPRC5B	9.77e-07	188	64	7	3559_UP
Drug	Mepenzolate bromide [76-90-4]; Up 200; 9.6uM; MCF7; HT_HG-U133A	JAK3 NF1 KCNAB2 CHRD DAPK1 HERC4 CPNE7	1.25e-06	195	64	7	3829_UP
Drug	Sulfamethazine sodium salt [1981-58-4]; Up 200; 13.4uM; MCF7; HT_HG-U133A	EPHB2 NF1 MRC2 KCNAB1 MECOM HERC4 CPNE7	1.29e-06	196	64	7	3847_UP
Drug	Lycorine hydrochloride [2188-68-3]; Up 200; 12.4uM; MCF7; HT_HG-U133A	TAOK2 TMEM144 MRC2 MECOM KLK1 HERC4 CPNE7	1.38e-06	198	64	7	3891_UP
Drug	naphthol AS-D chloroacetate	MPO PRTN3 GUSB ELANE ITGA5	1.69e-06	71	64	5	CID000160247
Drug	L-658,758	MPO PRTN3 ELANE	1.76e-06	9	64	3	CID000121963
Drug	AC1L3TUA	PRTN3 ELANE KLK1	7.54e-06	14	64	3	CID000122024
Drug	i14:0	MPO GUSB	7.78e-06	2	64	2	CID000520298
Drug	AC1O43R6	GUSB SLC4A2	7.78e-06	2	64	2	CID006323423
Drug	Antibodies, Antineutrophil Cytoplasmic	PRTN3 ELANE	7.78e-06	2	64	2	ctd:D019268
Drug	Piperacillin sodium salt [59703-84-3]; Up 200; 7.4uM; MCF7; HT_HG-U133A	NF1 MRC2 KCNAB2 CHRD DAPK1 HERC4	1.71e-05	193	64	6	3845_UP
Drug	Quinidine hydrochloride monohydrate [6151-40-2]; Up 200; 10.6uM; PC3; HT_HG-U133A	JAK3 TMEM144 KCNAB1 DMBT1 S1PR1 CPNE7	1.87e-05	196	64	6	5793_UP
Drug	Nabumetone [42924-53-8]; Up 200; 17.6uM; PC3; HT_HG-U133A	TMEM144 PRTN3 NF1 MRC2 KCNAB1 CPNE7	1.98e-05	198	64	6	6327_UP
Drug	2-(2-fluorobenzamido)benzoate ethyl ester	MPO ELANE	2.33e-05	3	64	2	ctd:C560790
Drug	1y2g	MPO PRTN3 ELANE MECOM SLC4A2	3.15e-05	129	64	5	CID005287936
Drug	diisopropylfluorophosphate	CLPP PRTN3 PRSS22 KLK14 ELANE KLK1 SLC4A2	3.24e-05	321	64	7	CID000005936
Drug	O(6)-benzyl-2'-deoxyguanosine	MGMT GUSB	4.65e-05	4	64	2	CID000125392
Drug	NSC-335754	MPO ELANE	4.65e-05	4	64	2	CID000333563
Drug	Malvin chloride	ELANE KLK1	4.65e-05	4	64	2	CID000073608
Drug	AC1N6F23	MPO ELANE	4.65e-05	4	64	2	CID004258953
Drug	NPC 15669	MPO PRTN3 ELANE	4.66e-05	25	64	3	CID000119365
Drug	epanolol	GUSB KLK14 KLK1	4.66e-05	25	64	3	CID000072014
Drug	urinastatin	MPO GUSB ELANE KLK1	7.28e-05	79	64	4	CID000105102
Drug	L-680,833	MPO ELANE	7.74e-05	5	64	2	CID000196813
Drug	imidazo(1,2-a)pyrimidine	MPO ELANE	7.74e-05	5	64	2	CID000577018
Drug	KC-764	MPO GUSB	7.74e-05	5	64	2	CID000146826
Drug	Zfrn-mec	ELANE KLK1 NLRC4	8.15e-05	30	64	3	CID000125187
Drug	Vgvapg	PRTN3 ELANE ITGA5	9.00e-05	31	64	3	CID000124934
Drug	NSC319712	MPO GUSB	1.16e-04	6	64	2	CID000432951
Drug	Alpatp	MPO ELANE	1.16e-04	6	64	2	CID000131722
Drug	AC1NX8KO	PRTN3 ELANE	1.16e-04	6	64	2	CID005748191
Drug	Leupeptin hydrochloride	CLPP GUSB MRC2 KLK14 ELANE KLK1	1.25e-04	276	64	6	CID000003910
Drug	naphthol-AS-D	MPO GUSB ELANE	1.54e-04	37	64	3	CID000067273
Drug	Pgaipg	ELANE ITGA5	1.62e-04	7	64	2	CID000192395
Drug	Metaraminol bitartrate [33402-03-8]; Up 200; 8.6uM; PC3; HT_HG-U133A	TMEM144 NF1 MRC2 DMBT1 CPNE7	1.82e-04	187	64	5	7368_UP
Drug	Nitrarine dihydrochloride [20069-05-0]; Up 200; 10.6uM; PC3; HT_HG-U133A	TAOK2 EPHB2 KCNAB1 AHCYL2 DMBT1	2.06e-04	192	64	5	7382_UP
Drug	sivelestat	MPO PRTN3 ELANE	2.09e-04	41	64	3	CID000107706
Drug	Gh32	TAOK2 NLRC4	2.15e-04	8	64	2	CID000148075
Drug	MeoSuc-AAPV-pNa	PRTN3 ELANE	2.15e-04	8	64	2	CID004419977
Drug	Ono 6818	MPO ELANE	2.15e-04	8	64	2	CID000004596
Drug	alminoprofen	GUSB KLK1	2.15e-04	8	64	2	CID000002097
Drug	Guaifenesin [93-14-1]; Up 200; 20.2uM; MCF7; HT_HG-U133A	EPHB2 MPO TMEM144 NF1 TRIM17	2.16e-04	194	64	5	4371_UP
Drug	Mebeverine hydrochloride [2753-45-9]; Down 200; 8.6uM; MCF7; HT_HG-U133A	TAOK2 MPO PRSS22 ITGA5 HERC4	2.16e-04	194	64	5	3193_DN
Drug	Cyproterone acetate [427-51-0]; Down 200; 9.6uM; PC3; HT_HG-U133A	EPHB2 PHF1 PRSS22 HERC4 CPNE7	2.16e-04	194	64	5	4470_DN
Drug	PNU-0230031 [267429-39-0]; Down 200; 1uM; PC3; HT_HG-U133A	TAOK2 PHF1 NF1 DMBT1 HERC4	2.16e-04	194	64	5	4291_DN
Drug	Trimethoprim [738-70-5]; Up 200; 13.8uM; PC3; HT_HG-U133A	EPHB2 PHF1 AHCYL2 DMBT1 S1PR1	2.22e-04	195	64	5	7377_UP
Drug	H-7 dihydrochloride; Up 200; 100uM; PC3; HT_HG-U133A	EPHB2 NF1 KCNAB1 DMBT1 CPNE7	2.22e-04	195	64	5	5941_UP
Drug	(1)-Nipecotic acid [498-95-3]; Up 200; 31uM; MCF7; HT_HG-U133A	EPHB2 KCNAB2 DMBT1 KLK1 CPNE7	2.27e-04	196	64	5	5999_UP
Drug	Zomepirac sodium salt [64092-48-4]; Up 200; 12.8uM; PC3; HT_HG-U133A	JAK3 TMEM144 NF1 KCNAB1 DMBT1	2.27e-04	196	64	5	4479_UP
Drug	Gemfibrozil [25812-30-0]; Up 200; 16uM; MCF7; HT_HG-U133A	NF1 KCNAB1 DAPK1 ITGA5 HERC4	2.27e-04	196	64	5	5488_UP
Drug	Guaifenesin [93-14-1]; Down 200; 20.2uM; PC3; HT_HG-U133A	EPHB2 NF1 AHCYL2 HERC4 CPNE7	2.27e-04	196	64	5	4549_DN
Drug	Bemegride [64-65-3]; Up 200; 25.8uM; MCF7; HT_HG-U133A	TAOK2 NF1 KCNAB2 DMBT1 HERC4	2.27e-04	196	64	5	5014_UP
Drug	Monensin sodium salt [22373-78-0]; Down 200; 5.8uM; MCF7; HT_HG-U133A	TAOK2 NF1 AHCYL2 GPRC5B CPNE7	2.32e-04	197	64	5	4726_DN
Drug	Mesalamine [89-57-6]; Down 200; 26.2uM; MCF7; HT_HG-U133A	TAOK2 PHF1 NF1 PRSS22 CLDN9	2.32e-04	197	64	5	3584_DN
Drug	PNU-0251126 [267429-19-6]; Up 200; 10uM; PC3; HT_HG-U133A	TAOK2 KCNAB2 KCNAB1 AHCYL2 CPNE7	2.32e-04	197	64	5	7388_UP
Drug	Griseofulvin [126-07-8]; Up 200; 11.2uM; PC3; HT_HG-U133A	TMEM144 PRTN3 MRC2 PRSS22 KLK1	2.32e-04	197	64	5	3664_UP
Drug	Pirenperone [ 75444-65-4]; Down 200; 10.2uM; PC3; HT_HG-U133A	EPHB2 NF1 KCNAB2 KCNAB1 CPNE7	2.32e-04	197	64	5	4679_DN
Drug	Pridinol methanesulfonate salt [6856-31-1]; Up 200; 10.2uM; PC3; HT_HG-U133A	MPO TMEM144 NF1 TM4SF5 DMBT1	2.32e-04	197	64	5	5860_UP
Drug	Ascorbic acid [50-81-7]; Up 200; 22.4uM; PC3; HT_HG-U133A	NF1 MRC2 TM4SF5 KCNAB1 CPNE7	2.32e-04	197	64	5	6306_UP
Drug	Todralazine hydrochloride [3778-76-5]; Up 200; 14.8uM; MCF7; HT_HG-U133A	MPO TPK1 MRC2 KCNAB1 MECOM	2.32e-04	197	64	5	5512_UP
Drug	Phenindione [83-12-5]; Up 200; 18uM; PC3; HT_HG-U133A	TAOK2 EPHB2 TMEM144 KCNAB2 KCNAB1	2.32e-04	197	64	5	7289_UP
Drug	Evoxine [522-11-2]; Up 200; 11.6uM; PC3; HT_HG-U133A	NF1 MRC2 KCNAB1 DMBT1 CLDN9	2.32e-04	197	64	5	3681_UP
Drug	Sparteine (-) [90-39-1]; Up 200; 17uM; MCF7; HT_HG-U133A	TAOK2 PHF1 JAK3 PRTN3 MRC2	2.32e-04	197	64	5	4391_UP
Drug	Acyclovir [59277-89-3]; Up 200; 17.8uM; MCF7; HT_HG-U133A	TAOK2 JAK3 KCNAB1 MECOM KLK1	2.38e-04	198	64	5	5278_UP
Drug	Meprylcaine hydrochloride [956-03-6]; Up 200; 14.8uM; PC3; HT_HG-U133A	NF1 TM4SF5 KCNAB1 S1PR1 GPRC5B	2.38e-04	198	64	5	5723_UP
Drug	Ebselen [60940-34-3]; Up 200; 14.6uM; PC3; HT_HG-U133A	PHF1 MRC2 KCNAB2 KCNAB1 CPNE7	2.38e-04	198	64	5	5778_UP
Drug	Evoxine [522-11-2]; Up 200; 11.6uM; PC3; HT_HG-U133A	NF1 MRC2 KCNAB2 KCNAB1 DMBT1	2.38e-04	198	64	5	7380_UP
Drug	Atropine-N-oxide hydrochloride [4574-60-1]; Up 200; 11.8uM; MCF7; HT_HG-U133A	EPHB2 PHF1 TMEM144 DMBT1 CPNE7	2.38e-04	198	64	5	6812_UP
Drug	Propoxycaine hydrochloride [550-83-4]; Up 200; 12uM; MCF7; HT_HG-U133A	TAOK2 EPHB2 JAK3 NF1 KCNAB2	2.38e-04	198	64	5	3583_UP
Drug	Niridazole [61-57-4]; Up 200; 18.6uM; PC3; HT_HG-U133A	EPHB2 PHF1 TMEM144 NF1 HERC4	2.38e-04	198	64	5	4621_UP
Drug	ionomycin calcium salt; Down 200; 2uM; MCF7; HT_HG-U133A_EA	IL10RB NF1 AHCYL2 ITGA5 HERC4	2.38e-04	198	64	5	871_DN
Drug	Heptaminol hydrochloride [543-15-7]; Up 200; 22uM; PC3; HT_HG-U133A	TAOK2 EPHB2 NF1 KCNAB2 HERC4	2.38e-04	198	64	5	7313_UP
Drug	Mecamylamine hydrochloride [826-39-1]; Up 200; 19.6uM; MCF7; HT_HG-U133A	EPHB2 TPK1 KCNAB2 MECOM ITGA5	2.38e-04	198	64	5	7023_UP
Drug	N-Acetyl-DL-homocysteine Thiolactone [1195-16-0]; Up 200; 25.2uM; HL60; HT_HG-U133A	TAOK2 EPHB2 JAK3 TM4SF5 KCNAB1	2.38e-04	198	64	5	2176_UP
Drug	Isoxicam [34552-84-6]; Up 200; 12uM; HL60; HT_HG-U133A	PHF1 NF1 MGMT KCNAB2 AHCYL2	2.43e-04	199	64	5	1862_UP
Drug	Papaverine hydrochloride [61-25-6]; Up 200; 10.6uM; MCF7; HT_HG-U133A	EPHB2 NF1 PRSS22 TM4SF5 CPNE7	2.43e-04	199	64	5	2747_UP
Drug	Solanine alpha [20562-02-1]; Up 200; 4.6uM; MCF7; HT_HG-U133A	TAOK2 EPHB2 KCNAB2 MECOM DAPK1	2.43e-04	199	64	5	4166_UP
Drug	Tiapride hydrochloride [51012-33-0]; Up 200; 11uM; MCF7; HT_HG-U133A	EPHB2 TPK1 PHF1 KCNAB1 DAPK1	2.43e-04	199	64	5	2292_UP
Drug	C75; Up 200; 10uM; MCF7; HT_HG-U133A	EPHB2 JAK3 PDE6G CD163 CPNE7	2.43e-04	199	64	5	6394_UP
Drug	Mebhydroline 1,5-naphtalenedisulfonate [6153-33-9]; Down 200; 4.8uM; PC3; HT_HG-U133A	TMEM144 NF1 KCNAB1 S1PR1 CPNE7	2.43e-04	199	64	5	4211_DN
Drug	rotenone; Up 200; 1uM; PC3; HT_HG-U133A	PRTN3 NF1 MRC2 PRSS22 KCNAB2	2.43e-04	199	64	5	5920_UP
Drug	Norgestrel-(-)-D [797-63-7]; Up 200; 12.8uM; MCF7; HT_HG-U133A	EPHB2 PHF1 JAK3 NF1 KLK1	2.43e-04	199	64	5	3606_UP
Drug	Moricizine hydrochloride [31883-05-3]; Up 200; 8.6uM; MCF7; HT_HG-U133A	TAOK2 PHF1 KCNAB2 KCNAB1 MECOM	2.43e-04	199	64	5	3520_UP
Drug	Meclozine dihydrochloride [1104-22-9]; Up 200; 8.6uM; PC3; HT_HG-U133A	EPHB2 TMEM144 NF1 KCNAB1 CD163	2.49e-04	200	64	5	4646_UP
Drug	Hoe 140	TRIM17 KLK14 ELANE KLK1	2.62e-04	110	64	4	CID000071362
Drug	IdB 1031	MPO ELANE	2.76e-04	9	64	2	CID000125309
Drug	2 Th	IL10RB ELANE	2.76e-04	9	64	2	CID015991546
Drug	fluoro dihydrogen phosphate	BIRC2 KLK1	2.76e-04	9	64	2	CID003014594
Drug	2',3'-dideoxy-3'-fluoro-5-ethyluridine	MPO ELANE	2.76e-04	9	64	2	CID000451414
Drug	3-deazaadenosylhomocysteine	ELANE AHCYL2	2.76e-04	9	64	2	CID000124126
Drug	AC1Q3O4D	MPO ELANE	2.76e-04	9	64	2	CID000059911
Drug	5-amino-2-nitrobenzoic acid	ELANE KLK1	2.76e-04	9	64	2	CID000083298
Drug	nimesulide	MPO KLK14 ELANE KLK1	3.00e-04	114	64	4	CID000004495
Drug	tetrabutylammonium	MPO GUSB PTDSS1	3.14e-04	47	64	3	CID000016027
Drug	TXB2 (thromboxane B2	MPO GUSB ELANE KLK1	3.43e-04	118	64	4	CID000005461
Drug	YT-146	MPO ELANE	3.45e-04	10	64	2	CID000146207
Drug	Polyanethole-sulfate	MPO GUSB	3.45e-04	10	64	2	CID006443175
Drug	SR 26831	ELANE KLK1	3.45e-04	10	64	2	CID000132270
Drug	AC1L48GE	MPO ELANE	3.45e-04	10	64	2	CID000181132
Drug	AC1OAH54	MPO CHRD	3.45e-04	10	64	2	CID006857729
Disease	neutrophil elastase measurement	PRTN3 ELANE	2.52e-05	4	61	2	EFO_0020605
Disease	kallikrein-7 measurement	CD163L1 CD163	4.19e-05	5	61	2	EFO_0008195
Disease	graft-versus-host disease (implicated_via_orthology)	JAK3 HLA-E	8.77e-05	7	61	2	DOID:0081267 (implicated_via_orthology)
Disease	juvenile myelomonocytic leukemia (is_implicated_in)	JAK3 NF1	8.77e-05	7	61	2	DOID:0050458 (is_implicated_in)
Disease	leukemia	NF1 MGMT BIRC2	2.04e-04	55	61	3	C0023418
Disease	glomerulonephritis (is_marker_for)	MPO CD163	7.03e-04	19	61	2	DOID:2921 (is_marker_for)
Disease	Juvenile Myelomonocytic Leukemia	JAK3 NF1	7.03e-04	19	61	2	C0349639
Disease	Glioma	NF1 MGMT DMBT1	7.87e-04	87	61	3	C0017638
Disease	glioblastoma (is_implicated_in)	MGMT DMBT1	1.13e-03	24	61	2	DOID:3068 (is_implicated_in)
Disease	L lactate dehydrogenase measurement	CD163L1 CD163	1.32e-03	26	61	2	EFO_0004808

Protein segments in the cluster

Peptide	Gene	Start	Entry
DPLGKDWCLLAMNLG	DAPK1	1321	P53355
AMGGICALFGLPWLA	SLC4A2	1041	P04920
VPGAGLGRLAWEIAM	CARNMT1	206	Q8N4J0
GTSICLGLLPVMGWN	GPR12	166	P47775
VGILCANGWGMNIAE	CD163L1	711	Q9NR16
LGPQLDMLWSGSRGC	JAK3	1091	P52333
MASPPRGWGCGELLL	PCDHGA5	1	Q9Y5G8
ELRESNMPGAGLGIW	MECOM	81	Q03112
LQWMHGCELGPDGRF	HLA-E	116	P13747
GPLMCDGVLQGVTSW	KLK1	216	P06870
LTALMLPWGCDVQGS	NLRC4	881	Q9NPP4
QGLVSWGMERCALPG	KLK14	231	Q9P0G3
GAMTWSPLACGIISG	KCNAB1	291	Q14722
AVLGGPEPLMQCTAW	MGMT	51	P16455
DSGGPLMCQVDGAWL	PRSS22	241	Q9GZN4
CNGDGEWLVPIGRCM	EPHB2	241	P29323
CMVDLGPCWAGGLTA	MPO	11	P05164
GPCWAGGLTAEMKLL	MPO	16	P05164
MLCWGNASFGQLGLG	HERC4	1	Q5GLZ8
FNLGTMQCLGTGWPG	MRC2	86	Q9UBG0
EARGGTVPGAWLCLM	GAS1	11	P54826
QCLAMGWGRVGAHDP	PRTN3	151	P24158
IGVGAMTWSPLACGI	KCNAB2	236	Q13303
GPAGWQLVGLALCLM	GPRC5B	156	Q9NZH0
CDLGNPMKAGASLWG	ITGA5	731	P08648
LGMGCWAREVLVPEG	IGSF8	21	Q969P0
LWGCALGLQGGMLYP	GUSB	16	P08236
GGMECTLGQPAQKWL	CPNE7	111	Q9UBL6
SHWLGRLMAGGCLPQ	C16orf90	81	A8MZG2
GSWLGGCLLVSALGM	IL10RB	6	Q08334
GNGVQCLAMGWGLLG	ELANE	146	P08246
IQEGPQCGLVALWMA	C19orf54	126	Q5BKX5
GKWNPDCLMIDGLVS	AHCTF1	716	Q8WYP5
EGTGPIWLDEMKCNG	CD163	776	Q86VB7
VCRQLGCGWAMLAPG	DMBT1	531	Q9UGM3
SLILGGLPIMGWNCI	S1PR1	171	P21453
MVLASGGQDGAICLW	SCAP	1131	Q12770
GMEGLGTDITVICPW	PDE6G	56	P18545
VCGLLVAMAWVGGFL	OR4C5	161	Q8NGB2
CGGPGEWNLKMLQCR	PHF1	191	O43189
PLVWQAPGTLCGGVM	NUTM2F	106	A1L443
PLVWQAPGTLCGGVM	NUTM2G	106	Q5VZR2
LGWLGQAGPLAMGAA	SOHLH1	261	Q5JUK2
GWQPNMILDDGGDLT	AHCYL2	301	Q96HN2
LLLAGECWGQGMAVP	PRORY	76	Q9H606
SKWLMGEGLEGLVPC	SIN3A	1231	Q96ST3
RGLMGVPLGLGAAWL	TAOK2	1036	Q9UL54
PCAVWLAGGMAGAIS	SLC25A48	216	Q6ZT89
PLMLSGGVGGICLWL	SLC25A15	211	Q9Y619
CGLMLDNWKLGDSPI	BIRC2	86	Q13490
LGWAAAALLMLGGGL	CLDN9	166	O95484
MWPGILVGGARVASC	CLPP	1	Q16740
MVALRGLGSGLQPWC	NCAPD3	1	P42695
LGELQMALEWAGRPG	CHRD	376	Q9H2X0
CNMELPHGGEGWQQL	PKMYT1	301	Q99640
PFAMLGGCIWATGNI	TMEM144	66	Q7Z5S9
PGMIKDCGATWVVLG	TPI1	81	P60174
GGMNRGLCPDLECVW	ZNF470	86	Q6ECI4
EWINMTGFLCALGGV	NF1	836	P21359
WGIAVGLLCQFGLMP	SLC10A6	66	Q3KNW5
MGPGLLCWVLLCPLG	TRBV5-7	1	A0A0A0MS05
MGPGLLCWALLCLLG	TRBV5-4	1	A0A0C4DH59
MGPGLLCWALLCLLG	TRBV5-6	1	A0A599
GMNITGDALWALGVC	TRIM17	356	Q9Y577
LCGEQPMCWEVGVGL	VWA5B2	846	Q8N398
GLRNGPRCLMNGEWG	TM4SF5	111	O14894
DILLCNGGGIWLGMV	PTDSS1	221	P48651
NGGGIWLGMVVCRFL	PTDSS1	226	P48651
MGPGLLCWELLYLLG	TRBV5-3	1	A0A0A0MS03
TGMEGDWCGLIPVGQ	TPK1	176	Q9H3S4
ACMWGIGTAIGELPP	VMP1	191	Q96GC9
LWGMCGPLLGDILHQ	ZNF776	91	Q68DI1