Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor	TXNRD3 TXNRD2 GSR	7.43e-06	12	66	3	GO:0016668
GeneOntologyMolecularFunction	protein tyrosine kinase activity	MAP2K4 TTBK1 FER ALK NRP1	1.18e-04	145	66	5	GO:0004713
GeneOntologyMolecularFunction	thioredoxin-disulfide reductase (NADPH) activity	TXNRD3 TXNRD2	2.24e-04	7	66	2	GO:0004791
GeneOntologyMolecularFunction	protein-disulfide reductase (NAD(P)H) activity	TXNRD3 TXNRD2	3.82e-04	9	66	2	GO:0047134
GeneOntologyMolecularFunction	disulfide oxidoreductase activity	TXNRD3 TXNRD2 GSR	3.87e-04	43	66	3	GO:0015036
GeneOntologyMolecularFunction	tau protein binding	TTBK2 TTBK1 HSPA2	4.73e-04	46	66	3	GO:0048156
GeneOntologyMolecularFunction	oxidoreductase activity, acting on a sulfur group of donors	TXNRD3 TXNRD2 GSR	8.88e-04	57	66	3	GO:0016667
Domain	Pyr_OxRdtase_I_AS	TXNRD3 TXNRD2 GSR	4.00e-07	5	65	3	IPR012999
Domain	Pyr_redox_dim	TXNRD3 TXNRD2 GSR	4.00e-07	5	65	3	PF02852
Domain	PYRIDINE_REDOX_1	TXNRD3 TXNRD2 GSR	4.00e-07	5	65	3	PS00076
Domain	-	TXNRD3 TXNRD2 GSR	1.39e-06	7	65	3	3.30.390.30
Domain	Pyr_nucl-diS_OxRdtase_dimer	TXNRD3 TXNRD2 GSR	2.23e-06	8	65	3	IPR004099
Domain	FAD/NAD-linked_Rdtase_dimer	TXNRD3 TXNRD2 GSR	2.23e-06	8	65	3	IPR016156
Domain	Thioredoxin/glutathione_Rdtase	TXNRD3 TXNRD2	3.57e-05	3	65	2	IPR006338
Domain	Pyr_redox_2	TXNRD3 TXNRD2 GSR	3.75e-05	19	65	3	PF07992
Domain	BTB-kelch_protein	KLHL34 KLHL33 KLHL20	4.49e-04	43	65	3	IPR017096
Domain	-	TXNRD3 TXNRD2 GSR	9.78e-04	56	65	3	3.50.50.60
Domain	FAD/NAD-binding_dom	TXNRD3 TXNRD2 GSR	1.03e-03	57	65	3	IPR023753
Domain	Kelch	KLHL34 KLHL33 KLHL20	1.08e-03	58	65	3	SM00612
Domain	BACK	KLHL34 KLHL33 KLHL20	1.19e-03	60	65	3	SM00875
Domain	BACK	KLHL34 KLHL33 KLHL20	1.25e-03	61	65	3	PF07707
Domain	BACK	KLHL34 KLHL33 KLHL20	1.25e-03	61	65	3	IPR011705
Domain	MAM_1	ALK NRP1	1.39e-03	16	65	2	PS00740
Domain	Acyl_Trfase/lysoPLipase	FASN PNPLA6	1.57e-03	17	65	2	IPR016035
Domain	MAM	ALK NRP1	1.76e-03	18	65	2	PF00629
Domain	ALDEHYDE_DEHYDR_GLU	ALDH16A1 ALDH3A1	1.76e-03	18	65	2	PS00687
Domain	MAM_dom	ALK NRP1	1.76e-03	18	65	2	IPR000998
Domain	MAM_2	ALK NRP1	1.76e-03	18	65	2	PS50060
Domain	ALDEHYDE_DEHYDR_CYS	ALDH16A1 ALDH3A1	1.76e-03	18	65	2	PS00070
Domain	Kelch_1	KLHL34 KLHL33 KLHL20	1.86e-03	70	65	3	PF01344
Domain	Kelch_1	KLHL34 KLHL33 KLHL20	1.86e-03	70	65	3	IPR006652
Domain	Ald_DH_C	ALDH16A1 ALDH3A1	1.96e-03	19	65	2	IPR016163
Domain	Ald_DH_N	ALDH16A1 ALDH3A1	1.96e-03	19	65	2	IPR016162
Domain	Ald_DH/histidinol_DH	ALDH16A1 ALDH3A1	1.96e-03	19	65	2	IPR016161
Domain	-	ALDH16A1 ALDH3A1	1.96e-03	19	65	2	3.40.605.10
Domain	Aldedh	ALDH16A1 ALDH3A1	1.96e-03	19	65	2	PF00171
Domain	Aldehyde_DH_dom	ALDH16A1 ALDH3A1	1.96e-03	19	65	2	IPR015590
Domain	-	ALDH16A1 ALDH3A1	1.96e-03	19	65	2	3.40.309.10
Domain	Protein_kinase_ATP_BS	TTBK2 MAP2K4 TTBK1 OBSCN FER ALK	2.02e-03	379	65	6	IPR017441
Domain	fn3	LRFN4 TRIM67 TSPOAP1 OBSCN	2.45e-03	162	65	4	PF00041
Domain	FN3	LRFN4 TRIM67 TSPOAP1 OBSCN	3.94e-03	185	65	4	SM00060
Domain	DnaJ_domain_CS	DNAJB13 DNAJB14	3.96e-03	27	65	2	IPR018253
Domain	SKP1/BTB/POZ	KCNS1 KLHL34 KLHL33 KLHL20	4.25e-03	189	65	4	IPR011333
Domain	PROTEIN_KINASE_TYR	OBSCN FER ALK	4.70e-03	97	65	3	PS00109
Domain	Tyr_kinase_AS	OBSCN FER ALK	4.70e-03	97	65	3	IPR008266
Domain	FN3	LRFN4 TRIM67 TSPOAP1 OBSCN	5.10e-03	199	65	4	PS50853
Domain	PROTEIN_KINASE_ATP	TTBK2 MAP2K4 TTBK1 OBSCN FER ALK	5.18e-03	459	65	6	PS00107
Domain	FN3_dom	LRFN4 TRIM67 TSPOAP1 OBSCN	6.06e-03	209	65	4	IPR003961
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	PRR12 FLNA FASN PNPLA6 ZNRF3 MTG2 KHNYN OBSCN TXNRD3 LHPP TXNRD2 ANKHD1 TBC1D24	1.62e-07	1105	67	13	35748872
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	FLNA MAP2K4 RAB3GAP1 NYAP2 FAM171A2 TSPOAP1 TEX2 SRCIN1 HSPA2 SLC39A7 TBC1D24 ATP5F1B	1.64e-06	1139	67	12	36417873
Pubmed	Large-scale proteomics and phosphoproteomics of urinary exosomes.	FLNA FASN RAB3GAP1 PRSS8 EML5 SLC13A2 ALDOC HSPA2 ALK GSR ATP5F1B	3.61e-06	1016	67	11	19056867
Pubmed	Pathological phosphorylation of tau and TDP-43 by TTBK1 and TTBK2 drives neurodegeneration.	TTBK2 TTBK1	3.66e-06	2	67	2	29409526
Pubmed	No selenium required: reactions catalyzed by mammalian thioredoxin reductase that are independent of a selenocysteine residue.	TXNRD3 TXNRD2	3.66e-06	2	67	2	19366212
Pubmed	Mechanisms of Regulation and Diverse Activities of Tau-Tubulin Kinase (TTBK) Isoforms.	TTBK2 TTBK1	3.66e-06	2	67	2	32424773
Pubmed	Modulation of tau tubulin kinases (TTBK1 and TTBK2) impacts ciliogenesis.	TTBK2 TTBK1	3.66e-06	2	67	2	37059819
Pubmed	The cytoplasmic domain of neuropilin-1 regulates focal adhesion turnover.	FLNA NRP1	3.66e-06	2	67	2	24021649
Pubmed	Plasticity in the Glucagon Interactome Reveals Novel Proteins That Regulate Glucagon Secretion in α-TC1-6 Cells.	FLNA FASN EFCAB6 ELN HSPA2 ATP5F1B	8.39e-06	247	67	6	30713523
Pubmed	Tau-tubulin kinase 1 (TTBK1), a neuron-specific tau kinase candidate, is involved in tau phosphorylation and aggregation.	TTBK2 TTBK1	1.10e-05	3	67	2	16923168
Pubmed	Redox regulation of cell signaling by selenocysteine in mammalian thioredoxin reductases.	TXNRD3 TXNRD2	1.10e-05	3	67	2	10455115
Pubmed	Selenoprotein oxidoreductase with specificity for thioredoxin and glutathione systems.	TXNRD3 TXNRD2	1.10e-05	3	67	2	11259642
Pubmed	The tau tubulin kinases TTBK1/2 promote accumulation of pathological TDP-43.	TTBK2 TTBK1	1.10e-05	3	67	2	25473830
Pubmed	Neuropilin 1 directly interacts with Fer kinase to mediate semaphorin 3A-induced death of cortical neurons.	FER NRP1	1.10e-05	3	67	2	20133938
Pubmed	Additional evidence for the role of chromosomal imbalances and SOX8, ZNRF3 and HHAT gene variants in early human testis development.	ZNRF3 SOX8	1.10e-05	3	67	2	36631813
Pubmed	The ubiquitin E3 ligase ARIH1 regulates hnRNP E1 protein stability, EMT and breast cancer progression.	FLNA FASN HSPA2 ATP5F1B	1.31e-05	74	67	4	35102251
Pubmed	Mammalian selenoprotein thioredoxin-glutathione reductase. Roles in disulfide bond formation and sperm maturation.	TXNRD3 TXNRD2	2.19e-05	4	67	2	15901730
Pubmed	Filamin associates with stress signalling kinases MKK7 and MKK4 and regulates JNK activation.	FLNA MAP2K4	2.19e-05	4	67	2	20156194
Pubmed	The selenoproteins GPx2, TrxR2 and TrxR3 are regulated by Wnt signalling in the intestinal epithelium.	TXNRD3 TXNRD2	2.19e-05	4	67	2	22683372
Pubmed	Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis.	FASN PITRM1 ALDH16A1 OBSCN TXNRD2 ALDOC HSPA2 GSR ATP5F1B	3.89e-05	859	67	9	31536960
Pubmed	Lysyl oxidase is essential for normal development and function of the respiratory system and for the integrity of elastic and collagen fibers in various tissues.	COL4A2 ELN	5.46e-05	6	67	2	16192629
Pubmed	Actin-binding protein-280 binds the stress-activated protein kinase (SAPK) activator SEK-1 and is required for tumor necrosis factor-alpha activation of SAPK in melanoma cells.	FLNA MAP2K4	5.46e-05	6	67	2	9006895
Pubmed	Update on the Kelch-like (KLHL) gene family.	KLHL34 KLHL33 KLHL20	6.91e-05	41	67	3	23676014
Pubmed	High-resolution comparative mapping of the proximal region of the mouse X chromosome.	CLCN5 CFP	7.63e-05	7	67	2	8530041
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	FLNA FASN NAT14 RAB3GAP1 PNPLA6 FAM171A2 ZNRF3 HSPA2 DNAJB14	7.91e-05	942	67	9	31073040
Pubmed	A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition.	TXNRD3 TXNRD2 HSPA2 GSR	8.45e-05	119	67	4	17601350
Pubmed	MYH9-dependent polarization of ATG9B promotes colorectal cancer metastasis by accelerating focal adhesion assembly.	FLNA FASN	1.02e-04	8	67	2	34131310
Pubmed	TTBK2 with EB1/3 regulates microtubule dynamics in migrating cells through KIF2A phosphorylation.	TTBK2 TTBK1	1.02e-04	8	67	2	26323690
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	DNAJB13 COL4A2 RAB3GAP1 PNPLA6 FAM171A2 TEX2 ALAS1 HSPA2 DNAJB14 GSR ATP5F1B	1.19e-04	1487	67	11	33957083
Pubmed	A new paradigm for MAPK: structural interactions of hERK1 with mitochondria in HeLa cells.	FASN ATP5F1B	1.30e-04	9	67	2	19847302
Pubmed	A mitochondrial SCF-FBXL4 ubiquitin E3 ligase complex degrades BNIP3 and NIX to restrain mitophagy and prevent mitochondrial disease.	FLNA FASN HSPA2	1.33e-04	51	67	3	36896912
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	PRR12 FLNA FASN SOX8 ANKHD1 SLC39A7	1.56e-04	418	67	6	34709266
Pubmed	Targeting the interaction of AIMP2-DX2 with HSP70 suppresses cancer development.	FLNA HSPA2 ATP5F1B	1.58e-04	54	67	3	31792442
Pubmed	Tagging single-nucleotide polymorphisms in antioxidant defense enzymes and susceptibility to breast cancer.	TXNRD2 GSR	1.63e-04	10	67	2	16424062
Pubmed	Interactions between genes involved in the antioxidant defence system and breast cancer risk.	TXNRD2 GSR	1.63e-04	10	67	2	16868544
Pubmed	OTUD4-mediated GSDME deubiquitination enhances radiosensitivity in nasopharyngeal carcinoma by inducing pyroptosis.	FLNA FASN	1.99e-04	11	67	2	36411454
Pubmed	Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin.	FLNA FASN HSPA2 GSR	2.01e-04	149	67	4	26370502
Pubmed	Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways.	FLNA FASN GSR ATP5F1B	2.17e-04	152	67	4	16009940
Pubmed	Desert hedgehog-primary cilia cross talk shapes mitral valve tissue by organizing smooth muscle actin.	FLNA ELN	3.28e-04	14	67	2	32151560
Pubmed	Epithelial β1 integrin is required for lung branching morphogenesis and alveolarization.	ELN GSR	3.28e-04	14	67	2	25395457
Pubmed	KIF7 Controls the Proliferation of Cells of the Respiratory Airway through Distinct Microtubule Dependent Mechanisms.	FASN ELN	3.78e-04	15	67	2	26439735
Pubmed	Defining the membrane proteome of NK cells.	FLNA FASN PNPLA6 CLCN5 ALDH16A1 PARP9 HSPA2 DNAJB14 ATP5F1B	3.92e-04	1168	67	9	19946888
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	FLNA MAP2K4 FASN PNPLA6 SRCIN1 ALDOC HSPA2 SLC39A7 TBC1D24 ATP5F1B	3.95e-04	1431	67	10	37142655
Pubmed	Elucidation of the AGR2 Interactome in Esophageal Adenocarcinoma Cells Identifies a Redox-Sensitive Chaperone Hub for the Quality Control of MUC-5AC.	FASN ALDH3A1 ATP5F1B	4.02e-04	74	67	3	31436131
Pubmed	CYLD Regulates Centriolar Satellites Proteostasis by Counteracting the E3 Ligase MIB1.	FASN PNPLA6 ALDH16A1 ALDOC	4.30e-04	182	67	4	31067453
Pubmed	Chemical Crosslinking Mass Spectrometry Analysis of Protein Conformations and Supercomplexes in Heart Tissue.	COL4A2 PITRM1 OBSCN TXNRD2 ATP5F1B	4.51e-04	331	67	5	29199018
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	COL4A2 NAT14 TLL1 HSPA2 DNAJB14 SLC39A7 GSR ATP5F1B NRP1	4.79e-04	1201	67	9	35696571
Pubmed	LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow.	FLNA FASN PITRM1 ALDOC ATP5F1B	5.37e-04	344	67	5	30333137
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	NYAP2 PITRM1 TEX2 SRCIN1 ANKHD1 TBC1D24	5.48e-04	529	67	6	14621295
Pubmed	Low 8-oxo-7,8-dihydro-2'-deoxyguanosine levels and influence of genetic background in an Andean population exposed to high levels of arsenic.	TXNRD2 GSR	5.48e-04	18	67	2	19896490
Pubmed	Type IV collagen drives alveolar epithelial-endothelial association and the morphogenetic movements of septation.	COL4A2 ELN	5.48e-04	18	67	2	27412481
Pubmed	Agrin has a pathological role in the progression of oral cancer.	COL4A2 PNPLA6 ALDOC SLC39A7	5.79e-04	197	67	4	29872149
Pubmed	Interactome of the Autoimmune Risk Protein ANKRD55.	FLNA FASN PNPLA6 ATP5F1B	5.79e-04	197	67	4	31620119
Pubmed	AIMP2-DX2 provides therapeutic interface to control KRAS-driven tumorigenesis.	FLNA FASN GSR ATP5F1B	6.13e-04	200	67	4	35546148
Pubmed	HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.	FLNA FASN NAT14 LRFN4 TEX2 TXNRD2 SLC39A7	6.16e-04	754	67	7	35906200
Pubmed	Compartmentalization of the SUMO/RNF4 pathway by SLX4 drives DNA repair.	FLNA FASN ANKHD1 GSR ATP5F1B	6.35e-04	357	67	5	37059091
Pubmed	The interactome of CLUH reveals its association to SPAG5 and its co-translational proximity to mitochondrial proteins.	FLNA PITRM1 ALDOC ATP5F1B	6.48e-04	203	67	4	35012549
Pubmed	Morphogenesis of the telencephalic commissure requires scaffold protein JNK-interacting protein 3 (JIP3).	MAP2K4 NRP1	6.79e-04	20	67	2	12897243
Pubmed	Defects of pelage hairs in 20 mouse mutations.	PRSS8 KRT25	6.79e-04	20	67	2	7738386
Pubmed	Proteomic identification of the TRAF6 regulation of vacuolar ATPase for osteoclast function.	HSPA2 ATP5F1B	7.50e-04	21	67	2	16196101
Pubmed	Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein.	FLNA FASN OBSCN ELN	7.89e-04	214	67	4	22199357
Pubmed	The interactome of intact mitochondria by cross-linking mass spectrometry provides evidence for coexisting respiratory supercomplexes.	PITRM1 OBSCN ALAS1 TXNRD2 ATP5F1B	8.61e-04	382	67	5	29222160
Pubmed	Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation.	COL4A2 COL6A6 ELN	8.85e-04	97	67	3	27559042
Pubmed	A mitochondrial protein compendium elucidates complex I disease biology.	FASN PITRM1 MTG2 ALAS1 ELN TXNRD2 GSR ATP5F1B	8.90e-04	1047	67	8	18614015
Pubmed	Aldehyde dehydrogenase 1a1 is dispensable for stem cell function in the mouse hematopoietic and nervous systems.	ALDH16A1 ALDH3A1	9.01e-04	23	67	2	18971422
Pubmed	Systematic identification of cancer cell vulnerabilities to natural killer cell-mediated immune surveillance.	FLNA FASN ALDH16A1 OBSCN	9.66e-04	226	67	4	31452512
Pubmed	Highly efficient purification of protein complexes from mammalian cells using a novel streptavidin-binding peptide and hexahistidine tandem tag system: application to Bruton's tyrosine kinase.	FLNA ATP5F1B	9.82e-04	24	67	2	21080425
Pubmed	In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.	COL4A2 FLNA FASN PRSS8 ALDOC KRT25 GSR ATP5F1B	1.02e-03	1070	67	8	23533145
Pubmed	Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.	LRFN4 GAL3ST3 ALAS1	1.02e-03	102	67	3	21926972
Pubmed	KCTD9 inhibits the Wnt/β-catenin pathway by decreasing the level of β-catenin in colorectal cancer.	FLNA FASN ATP5F1B	1.08e-03	104	67	3	36055981
Pubmed	Proteomic Analysis of the Spinophilin Interactome in Rodent Striatum Following Psychostimulant Sensitization.	FASN SRCIN1 ALDOC HSPA2 ATP5F1B	1.09e-03	403	67	5	30562941
Pubmed	Expanding the Interactome of TES by Exploiting TES Modules with Different Subcellular Localizations.	FLNA RAB3GAP1 KIF27 ATP5F1B	1.12e-03	235	67	4	28378594
Pubmed	Targeted deletion of the mitogen-activated protein kinase kinase 4 gene in the nervous system causes severe brain developmental defects and premature death.	FLNA MAP2K4	1.15e-03	26	67	2	17875933
Pubmed	Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage.	TTBK2 FLNA FASN ALDOC HSPA2 GSR ATP5F1B	1.19e-03	844	67	7	25963833
Pubmed	Same but different - Molecular comparison of human KTI12 and PSTK.	RAB3GAP1 FAM171A2	1.24e-03	27	67	2	33417976
Pubmed	Mice carrying a hypomorphic Evi1 allele are embryonic viable but exhibit severe congenital heart defects.	FLNA NRP1	1.24e-03	27	67	2	24586749
Pubmed	Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer.	FBXO10 TXNRD2 GSR	1.52e-03	117	67	3	19124506
Pubmed	Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey.	TXNRD2 HSPA2 GSR	1.52e-03	117	67	3	18977241
Pubmed	Multi-omics profiling identifies a deregulated FUS-MAP1B axis in ALS/FTD-associated UBQLN2 mutants.	FLNA FASN ALDOC ATP5F1B	1.53e-03	256	67	4	35777956
Pubmed	Tissue-Specific Regulation of the Wnt/β-Catenin Pathway by PAGE4 Inhibition of Tankyrase.	FLNA FASN GSR ATP5F1B	1.53e-03	256	67	4	32698014
Pubmed	Heritable Thoracic Aortic Disease Overview	FLNA ELN	1.54e-03	30	67	2	20301299
Pubmed	Tumor suppressor BAP1 nuclear import is governed by transportin-1.	FLNA FASN KHNYN ANKHD1 ALDOC HSPA2 GSR ATP5F1B	1.61e-03	1149	67	8	35446349
Pubmed	Maternal synchronization of gestational length and lung maturation.	FASN ELN	1.64e-03	31	67	2	22096492
Pubmed	Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function.	HSPA2 KLHL20	1.75e-03	32	67	2	12493773
Pubmed	A germline-specific class of small RNAs binds mammalian Piwi proteins.	GOLGA8DP TTBK2 GOLGA8CP ALDH16A1 ALAS1	1.77e-03	450	67	5	16751776
Pubmed	Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.	FLNA FASN CLCN5 PITRM1 ALAS1 SLC39A7 GSR ATP5F1B NRP1	1.81e-03	1451	67	9	30550785
Pubmed	Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.	PRR12 PNPLA6 ALDH16A1 ANKHD1 GSR	1.90e-03	457	67	5	32344865
GeneFamily	Kelch like\|BTB domain containing	KLHL34 KLHL33 KLHL20	1.65e-04	42	46	3	617
GeneFamily	Fibronectin type III domain containing	LRFN4 TRIM67 TSPOAP1 OBSCN	7.22e-04	160	46	4	555
GeneFamily	Aldehyde dehydrogenases	ALDH16A1 ALDH3A1	1.05e-03	19	46	2	398
GeneFamily	Selenoproteins	TXNRD3 TXNRD2	1.83e-03	25	46	2	890
GeneFamily	Collagens	COL4A2 COL6A6	6.10e-03	46	46	2	490
GeneFamily	DNAJ (HSP40) heat shock proteins\|C2 tensin-type domain containing	DNAJB13 DNAJB14	6.90e-03	49	46	2	584
ToppCell	Differ-Basal\|World / shred by cell class for mouse tongue	ZNRF3 ALAS1 ELN ALDH3A1 ALDOC GSR	4.77e-07	194	67	6	851eff82c9f3d44c86e3e127a804bbd1fced6a7c
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Neuronal-neurons_A-Branch_A4_(IN)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TRIM67 EML5 GAL3ST3 SRCIN1 ALK	8.08e-06	182	67	5	be32b5b8153c1053cbb55f1fccfa27c3ee97c1e1
ToppCell	10x3'2.3-week_14-16-Mesenchymal_fibro-stroma-endosteal_fibroblast\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	COL6A6 TLL1 ELN SOX8 KRT25	9.45e-06	188	67	5	0e2d1b21f0a7ee306e7dae16fc8c19d16a467883
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PRSS8 CLCN5 HSPA2 TBC1D24 ATP5F1B	1.05e-05	192	67	5	8769b67d1cad1be65da3938f916e5bf88f88f6b8
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PRSS8 CLCN5 HSPA2 TBC1D24 ATP5F1B	1.05e-05	192	67	5	7af2b5240b1fad2177d8022e5f4fc1fe9e8f03b5
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PRSS8 CLCN5 HSPA2 TBC1D24 ATP5F1B	1.05e-05	192	67	5	32e4a180037e516c5cc798cd9dada9385e0f43ae
ToppCell	LPS_anti-TNF-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	FASN EML5 ALAS1 SLC13A2 SLC39A7	1.19e-05	197	67	5	1485933986921ff45669d9b7501c8d17050b3e97
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW26\|fetalBrain_Zhong_nature / Sample Type, Dataset, Time_group, and Cell type.	FASN TRIM67 OBSCN SRCIN1 ALDOC	1.27e-05	200	67	5	61d7dd0a78942b069c3f5e75044368dc00e6e8e6
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW26\|organoid_Tanaka_cellReport / Sample Type, Dataset, Time_group, and Cell type.	FASN TRIM67 OBSCN SRCIN1 ALDOC	1.27e-05	200	67	5	5c7263c862093ad9dbc81d06b16b6f74e8a6b634
Disease	Depressive Symptoms	FASN KCNS1 TXNRD2	2.22e-05	26	62	3	C0086132
Disease	triglyceride change measurement, response to exercise	NYAP2 DPEP2	1.55e-04	9	62	2	EFO_0007681, EFO_0007768
Disease	Small cell carcinoma of lung	COL4A2 TTBK2 FER	2.03e-04	54	62	3	C0149925
Disease	BMI-adjusted adiponectin measurement	NYAP2 ALK	4.48e-04	15	62	2	EFO_0007737
Disease	progranulin measurement	MAP2K4 FAM171A2	9.77e-04	22	62	2	EFO_0004625
Disease	Ovarian Serous Adenocarcinoma	MAP2K4 ALK	1.07e-03	23	62	2	C1335177
Disease	Pancreatic Neoplasm	MAP2K4 ZNRF3 NRP1	1.24e-03	100	62	3	C0030297
Disease	Malignant neoplasm of pancreas	MAP2K4 ZNRF3 NRP1	1.31e-03	102	62	3	C0346647
Disease	prostate carcinoma in situ (is_marker_for)	MAP2K4 PRSS8	1.59e-03	28	62	2	DOID:8634 (is_marker_for)
Disease	aortic measurement	MAP2K4 TLL1 ELN SOX8	1.94e-03	251	62	4	EFO_0020865

Protein segments in the cluster

Peptide	Gene	Start	Entry
GYVAEGGAKDIRGAV	ALDH16A1	556	Q8IZ83
GLAAQGKYEGSGEDG	ALDOC	336	P09972
GKYEGSGEDGGAAAQ	ALDOC	341	P09972
GLIEGQKVAYGGTGD	ALDH3A1	296	P30838
DYLVIGGGSGGLASA	GSR	66	P00390
FGYSDGVVVGDEGKG	FBXO10	621	Q9UK96
RGLGFYGVKGEKGDV	COL4A2	231	P08572
GRAGLYGEIGATGDF	COL4A2	1076	P08572
YAKGGKIGLFGGAGV	ATP5F1B	196	P06576
DLKDLGEIGRGAYGS	MAP2K4	101	P45985
IDALVGGEVGGLEFG	RAB3GAP1	251	Q15042
KDADGFYQGEGGGRT	TSPOAP1	1666	O95153
GGGLALALVKAGGFE	PARP9	146	Q8IXQ6
GDGVAAGGDYKGHSK	GOLGA8F;	326	Q08AF8
GSGKKELVGEYGRGD	PNPLA6	681	Q8IY17
LGGRLYVAGGLGETE	KLHL33	416	A6NCF5
GDRGVVYISGGKAGR	KLHL34	471	Q8N239
VYISGGKAGRGEGGA	KLHL34	476	Q8N239
ALDAAAGEYSGGVLG	NKX2-4	331	Q9H2Z4
VVQLGGKGYGSESGE	NEIL1	236	Q96FI4
DEVHAVGLYGARGGG	ALAS1	411	P13196
AIAYGLDKKGCAGGE	HSPA2	181	P54652
YQEAGDGVLKPEGGG	KIF27	1241	Q86VH2
VGGMLEGCGYQAEGG	NAT14	176	Q8WUY8
LIGGDDGACKSGGYK	KRT25	386	Q7Z3Z0
LAGVALGDQGGKEFG	KCNS1	321	Q96KK3
LDISGVLYDSGAGGG	LHPP	16	Q9H008
YEESSGKCKGLLGGG	CFP	36	P27918
GGEVGRGHEGSYVGK	NYAP2	76	Q9P242
YVRLGGEAGAAGVGD	FAM171A2	546	A8MVW0
GGGLCGYRVEVKEGA	OBSCN	4551	Q5VST9
KFSLGGRGGYAGVAG	OBSCN	7176	Q5VST9
FEGEIGKGNLGGIAV	NRP1	781	O14786
KVDIMGYDLPGGGAG	GAL3ST3	361	Q96A11
GDGVAAGGDYKGHSK	GOLGA8DP	326	Q0D2H9
AVLGGFLYAVGGSDG	KLHL20	456	Q9Y2M5
GGIDLYINGIKRGGG	EFCAB6	136	Q5THR3
GELLGKGNFGEVYKG	FER	566	P16591
GEGGKGYTKDQVDGV	DNAJB14	86	Q8TBM8
LVSAYGAGLEGGVTG	FLNA	2431	P21333
GKVGAHAGEYGAEAL	HBA1;	16	P69905
REVGEDKSYNGGGIG	CLCN5	51	P51795
RGIYDKFGEEGLKGG	DNAJB13	61	P59910
IGSKFIGIGGDYDGA	DPEP2	341	Q9H4A9
IGIGGDYDGAGKFPQ	DPEP2	346	Q9H4A9
ALGKEEIALGGGGFC	KHNYN	306	O15037
AGGGLIGRKGYIGTL	EML5	846	Q05BV3
LRAKTGGAYGEDLGA	FASN	2446	P49327
AAKYGAAGLGGVLGG	ELN	736	P15502
GGGYALAKGSERSGL	SLC13A2	426	Q13183
FKGSEGYLGEEGIAG	COL6A6	1411	A6NMZ7
AGGGGSRVELLVFGY	SFSWAP	26	Q12872
GKGFAAVYEAICGGE	TLL1	451	O43897
HTEIREKGGAYGGGA	PITRM1	896	Q5JRX3
VGDEYIAALGGAGGK	MTG2	176	Q9H4K7
PGGGAVYKAEAGLGD	SOX8	196	P57073
GAGGYKGKGDGSELL	PRR12	611	Q9ULL5
YVEGGKDACQGDSGG	PRSS8	226	Q16651
AAGGGGRAYGAKTDT	ALK	841	Q9UM73
SGGYAEVGRVLLDKG	ANKHD1	1266	Q8IWZ3
LIVGGGGGQALYIDG	TBC1D24	506	Q9ULP9
GAGGGGDHADKLSLY	TRIM67	91	Q6ZTA4
VLKKIGGGGFGEIYE	TTBK1	36	Q5TCY1
DLEDSLYKAAGGGGP	SRCIN1	446	Q9C0H9
LGGVIDAGGETQGYL	ROM1	296	Q03395
GYGESGAPGIKQDLD	SLC39A7	116	Q92504
KIGGGGFGEIYDALD	TTBK2	26	Q6IQ55
GQRDYDLLVVGGGSG	TXNRD2	36	Q9NNW7
FYEEKQVARGGGGGS	ZNRF3	781	Q9ULT6
DYDLIIIGGGSGGLS	TXNRD3	156	Q86VQ6
GGDKQLLPGAEGYVG	TEX2	966	Q8IWB9
AAGAAGGKGEERYAE	TEX13B	191	Q9BXU2
AAGDGVAAGGDYKGH	GOLGA8CP	491	A6NN73
LEIGVTGAGDAGGYT	LRFN4	336	Q6PJG9