Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	microtubule motor activity	DNAH12 KIF26B KIF4A KIF4B	1.55e-04	70	77	4	GO:0003777
GeneOntologyCellularComponent	symmetric, GABA-ergic, inhibitory synapse	NLGN4X NLGN4Y	8.00e-05	4	77	2	GO:0098983
GeneOntologyCellularComponent	inhibitory synapse	NLGN4X NLGN4Y BSN	2.01e-04	31	77	3	GO:0060077
Domain	CUB	MASP1 TLL1 TLL2 DMBT1 CUBN	1.62e-06	49	76	5	PF00431
Domain	CUB	MASP1 TLL1 TLL2 DMBT1 CUBN	1.79e-06	50	76	5	SM00042
Domain	-	MASP1 TLL1 TLL2 DMBT1 CUBN	2.19e-06	52	76	5	2.60.120.290
Domain	CUB	MASP1 TLL1 TLL2 DMBT1 CUBN	2.41e-06	53	76	5	PS01180
Domain	CUB_dom	MASP1 TLL1 TLL2 DMBT1 CUBN	3.47e-06	57	76	5	IPR000859
Domain	NLGN4	NLGN4X NLGN4Y	1.63e-05	2	76	2	IPR030025
Domain	BMP_1/tolloid-like	TLL1 TLL2	4.89e-05	3	76	2	IPR015446
Domain	Nlgn	NLGN4X NLGN4Y	1.62e-04	5	76	2	IPR000460
Domain	Peptidase_M12A	TLL1 TLL2	2.43e-04	6	76	2	IPR001506
Domain	Astacin	TLL1 TLL2	2.43e-04	6	76	2	PF01400
Domain	EGF_CA	MASP1 TLL1 TLL2 CUBN	4.18e-04	86	76	4	PF07645
Domain	EGF_Ca-bd_CS	MASP1 TLL1 TLL2 CUBN	6.59e-04	97	76	4	IPR018097
Domain	Kinesin-like_fam	KIF26B KIF4A KIF4B	7.11e-04	43	76	3	IPR027640
Domain	EGF_CA	MASP1 TLL1 TLL2 CUBN	7.11e-04	99	76	4	PS01187
Domain	KINESIN_MOTOR_1	KIF26B KIF4A KIF4B	7.61e-04	44	76	3	PS00411
Domain	-	KIF26B KIF4A KIF4B	7.61e-04	44	76	3	3.40.850.10
Domain	Kinesin_motor_dom	KIF26B KIF4A KIF4B	7.61e-04	44	76	3	IPR001752
Domain	Kinesin	KIF26B KIF4A KIF4B	7.61e-04	44	76	3	PF00225
Domain	KINESIN_MOTOR_2	KIF26B KIF4A KIF4B	7.61e-04	44	76	3	PS50067
Domain	KISc	KIF26B KIF4A KIF4B	7.61e-04	44	76	3	SM00129
Domain	EGF-type_Asp/Asn_hydroxyl_site	MASP1 TLL1 TLL2 CUBN	9.19e-04	106	76	4	IPR000152
Domain	Carboxylesterase_B_CS	NLGN4X NLGN4Y	1.24e-03	13	76	2	IPR019819
Domain	CARBOXYLESTERASE_B_2	NLGN4X NLGN4Y	1.44e-03	14	76	2	PS00941
Domain	COesterase	NLGN4X NLGN4Y	1.44e-03	14	76	2	PF00135
Domain	CarbesteraseB	NLGN4X NLGN4Y	1.44e-03	14	76	2	IPR002018
Domain	LRR_6	TONSL NLRC5 NRROS	1.46e-03	55	76	3	PF13516
Domain	EGF_CA	MASP1 TLL1 TLL2 CUBN	1.55e-03	122	76	4	SM00179
Domain	EGF-like_Ca-bd_dom	MASP1 TLL1 TLL2 CUBN	1.64e-03	124	76	4	IPR001881
Domain	EGF	TLL1 TLL2 CUBN ITGB5	1.74e-03	126	76	4	PF00008
Domain	Rib_L2_dom2	HERC2 UHRF2	2.40e-03	18	76	2	IPR014722
Domain	ZZ	HERC2 DMD	2.40e-03	18	76	2	PF00569
Domain	-	HERC2 UHRF2	2.40e-03	18	76	2	2.30.30.30
Domain	ZF_ZZ_2	HERC2 DMD	2.40e-03	18	76	2	PS50135
Domain	ZF_ZZ_1	HERC2 DMD	2.40e-03	18	76	2	PS01357
Domain	Znf_ZZ	HERC2 DMD	2.67e-03	19	76	2	IPR000433
Domain	ZnF_ZZ	HERC2 DMD	2.67e-03	19	76	2	SM00291
Domain	-	PIK3AP1 ASAP2 TONSL ANKS1B ANKRD30A	3.40e-03	248	76	5	1.25.40.20
Domain	Ankyrin_rpt-contain_dom	PIK3AP1 ASAP2 TONSL ANKS1B ANKRD30A	3.77e-03	254	76	5	IPR020683
Domain	EGF_1	MASP1 TLL1 TLL2 CUBN ITGB5	3.83e-03	255	76	5	PS00022
Domain	Actinin_actin-bd_CS	FLNA DMD	3.91e-03	23	76	2	IPR001589
Domain	ACTININ_2	FLNA DMD	3.91e-03	23	76	2	PS00020
Domain	ACTININ_1	FLNA DMD	3.91e-03	23	76	2	PS00019
Domain	EGF-like_CS	MASP1 TLL1 TLL2 CUBN ITGB5	4.23e-03	261	76	5	IPR013032
Domain	EGF_2	MASP1 TLL1 TLL2 CUBN ITGB5	4.51e-03	265	76	5	PS01186
Domain	HECT	HERC2 SMURF2	5.37e-03	27	76	2	PF00632
Domain	HECTc	HERC2 SMURF2	5.37e-03	27	76	2	SM00119
Domain	HECT_dom	HERC2 SMURF2	5.37e-03	27	76	2	IPR000569
Domain	HECT	HERC2 SMURF2	5.37e-03	27	76	2	PS50237
Domain	PID	APBA2 ANKS1B	5.77e-03	28	76	2	PF00640
Domain	TRYPSIN_SER	MASP1 KLK8 KLK1	5.90e-03	90	76	3	IPR033116
Domain	ZnMc	TLL1 TLL2	6.18e-03	29	76	2	SM00235
Domain	Peptidase_Metallo	TLL1 TLL2	6.18e-03	29	76	2	IPR006026
Domain	-	ASAP2 DNMBP	6.60e-03	30	76	2	1.20.1270.60
Domain	AH/BAR-dom	ASAP2 DNMBP	6.60e-03	30	76	2	IPR027267
Domain	SAM	DLC1 UBP1 ANKS1B	7.26e-03	97	76	3	IPR001660
Domain	PID	APBA2 ANKS1B	7.49e-03	32	76	2	PS01179
Domain	PH_dom-like	PPP4R3B ASAP2 APBA2 ANKS1B NBEA PSD4	7.76e-03	426	76	6	IPR011993
Pathway	KEGG_MEDICUS_REFERENCE_BCR_BCAP_CD19_PI3K_SIGNALING_PATHWAY	PIK3AP1 PIK3R3 SYK	4.28e-05	15	66	3	M47971
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	PPP4R3B USP34 DLGAP1 SNRNP48 ZNF334 MTIF2 APBA2 ANKS1B NBEA DNAAF9 HERC2 CBS SMURF2 SNX5	1.09e-06	1285	79	14	35914814
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	DLGAP1 ASAP2 PDE4D NLGN4X NLGN4Y ANKS1B NBEA	3.68e-06	281	79	7	28706196
Pubmed	KIF4 regulates neuronal morphology and seizure susceptibility via the PARP1 signaling pathway.	KIF4A KIF4B	5.09e-06	2	79	2	36482480
Pubmed	The multiple functions of kinesin-4 family motor protein KIF4 and its clinical potential.	KIF4A KIF4B	5.09e-06	2	79	2	30081192
Pubmed	Chromokinesin Kif4 promotes proper anaphase in mouse oocyte meiosis.	KIF4A KIF4B	5.09e-06	2	79	2	31067151
Pubmed	Development of an autism severity score for mice using Nlgn4 null mutants as a construct-valid model of heritable monogenic autism.	NLGN4X NLGN4Y	5.09e-06	2	79	2	23183221
Pubmed	Juvenile manifestation of ultrasound communication deficits in the neuroligin-4 null mutant mouse model of autism.	NLGN4X NLGN4Y	5.09e-06	2	79	2	24855039
Pubmed	Cellular motor protein KIF-4 associates with retroviral Gag.	KIF4A KIF4B	5.09e-06	2	79	2	10559369
Pubmed	Sex-specific microglia state in the Neuroligin-4 knock-out mouse model of autism spectrum disorder.	NLGN4X NLGN4Y	5.09e-06	2	79	2	37001827
Pubmed	Huntingtin interacts with cystathionine beta-synthase.	CBS HTT	5.09e-06	2	79	2	9466992
Pubmed	Huntingtin is associated with cytomatrix proteins at the presynaptic terminal.	BSN HTT	5.09e-06	2	79	2	25461618
Pubmed	KIF4 regulates midzone length during cytokinesis.	KIF4A KIF4B	5.09e-06	2	79	2	21565503
Pubmed	A novel microtubule-based motor protein (KIF4) for organelle transports, whose expression is regulated developmentally.	KIF4A KIF4B	5.09e-06	2	79	2	7929562
Pubmed	Whole genome expression microarray reveals novel roles for Kif4 in monocyte/macrophage cells.	KIF4A KIF4B	5.09e-06	2	79	2	31486502
Pubmed	Assignment of the kinesin family member 4 genes (KIF4A and KIF4B) to human chromosome bands Xq13.1 and 5q33.1 by in situ hybridization.	KIF4A KIF4B	5.09e-06	2	79	2	10773663
Pubmed	The localization and interactions of huntingtin.	CBS HTT	5.09e-06	2	79	2	10434301
Pubmed	Missense Pathogenic variants in KIF4A Affect Dental Morphogenesis Resulting in X-linked Taurodontism, Microdontia and Dens-Invaginatus.	KIF4A KIF4B	5.09e-06	2	79	2	31616463
Pubmed	Unusually rapid evolution of Neuroligin-4 in mice.	NLGN4X NLGN4Y	5.09e-06	2	79	2	18434543
Pubmed	Kif4 regulates the expression of VEGFR1 through the PI3K/Akt signaling pathway in RAW264.7 monocytes/macrophages.	KIF4A KIF4B	5.09e-06	2	79	2	28350061
Pubmed	Syk protein tyrosine kinase involves PECAM-1 signaling through tandem immunotyrosine inhibitory motifs in human THP-1 macrophages.	PECAM1 SYK	5.09e-06	2	79	2	22000807
Pubmed	A novel interaction between FlnA and Syk regulates platelet ITAM-mediated receptor signaling and function.	FLNA SYK	5.09e-06	2	79	2	20713593
Pubmed	Kif4 interacts with EB1 and stabilizes microtubules downstream of Rho-mDia in migrating fibroblasts.	KIF4A KIF4B	5.09e-06	2	79	2	24658398
Pubmed	Increased Network Inhibition in the Dentate Gyrus of Adult Neuroligin-4 Knock-Out Mice.	NLGN4X NLGN4Y	5.09e-06	2	79	2	37080762
Pubmed	Autism Related Neuroligin-4 Knockout Impairs Intracortical Processing but not Sensory Inputs in Mouse Barrel Cortex.	NLGN4X NLGN4Y	5.09e-06	2	79	2	29106499
Pubmed	Perturbed Hippocampal Synaptic Inhibition and γ-Oscillations in a Neuroligin-4 Knockout Mouse Model of Autism.	NLGN4X NLGN4Y	5.09e-06	2	79	2	26456829
Pubmed	Nlgn4 knockout induces network hypo-excitability in juvenile mouse somatosensory cortex in vitro.	NLGN4X NLGN4Y	5.09e-06	2	79	2	24104404
Pubmed	A Cluster of Autism-Associated Variants on X-Linked NLGN4X Functionally Resemble NLGN4Y.	NLGN4X NLGN4Y	5.09e-06	2	79	2	32243781
Pubmed	Identification and characterization of Dlc1 isoforms in the mouse and study of the biological function of a single gene trapped isoform.	DLC1 PECAM1	5.09e-06	2	79	2	20199662
Pubmed	Absence of deficits in social behaviors and ultrasonic vocalizations in later generations of mice lacking neuroligin4.	NLGN4X NLGN4Y	5.09e-06	2	79	2	22989184
Pubmed	Structural basis for the ATP-induced isomerization of kinesin.	KIF4A KIF4B	5.09e-06	2	79	2	23500491
Pubmed	Binding of murine leukemia virus Gag polyproteins to KIF4, a microtubule-based motor protein.	KIF4A KIF4B	5.09e-06	2	79	2	9658142
Pubmed	Multiple bone morphogenetic protein 1-related mammalian metalloproteinases process pro-lysyl oxidase at the correct physiological site and control lysyl oxidase activation in mouse embryo fibroblast cultures.	TLL1 TLL2	5.09e-06	2	79	2	11313359
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	FLNA PDE4D IPO7 ANKRD30A ITPRID2 HERC2	6.96e-06	202	79	6	33005030
Pubmed	Regulation of cell surface protease matriptase by HAI2 is essential for placental development, neural tube closure and embryonic survival in mice.	PECAM1 KLK8 KLK1	1.46e-05	21	79	3	19592578
Pubmed	Choroideremia gene product affects trophoblast development and vascularization in mouse extra-embryonic tissues.	PECAM1 CHM	1.53e-05	3	79	2	15242790
Pubmed	Structural basis for the substrate specificity of bone morphogenetic protein 1/tolloid-like metalloproteases.	TLL1 TLL2	1.53e-05	3	79	2	18824173
Pubmed	Tumor formation via loss of a molecular motor protein.	KIF4A KIF4B	1.53e-05	3	79	2	16890532
Pubmed	KIF4 mediates anterograde translocation and positioning of ribosomal constituents to axons.	KIF4A KIF4B	1.53e-05	3	79	2	19158085
Pubmed	Identification of the human homologue of mouse KIF4, a kinesin superfamily motor protein.	KIF4A KIF4B	1.53e-05	3	79	2	10978527
Pubmed	Evolution of the Autism-Associated Neuroligin-4 Gene Reveals Broad Erosion of Pseudoautosomal Regions in Rodents.	NLGN4X NLGN4Y	1.53e-05	3	79	2	32011705
Pubmed	Targeted disruption of cubilin reveals essential developmental roles in the structure and function of endoderm and in somite formation.	PECAM1 CUBN	1.53e-05	3	79	2	16787536
Pubmed	B-cell adaptor for PI3K (BCAP) negatively regulates Toll-like receptor signaling through activation of PI3K.	PIK3AP1 SYK	1.53e-05	3	79	2	22187458
Pubmed	Analysis of the neuroligin 4Y gene in patients with autism.	NLGN4X NLGN4Y	1.53e-05	3	79	2	18628683
Pubmed	Assignment of TLL1 and TLL2, which encode human BMP-1/Tolloid-related metalloproteases, to chromosomes 4q32-->q33 and 10q23-->q24 and assignment of murine Tll2 to chromosome 19.	TLL1 TLL2	1.53e-05	3	79	2	10516436
Pubmed	KIF4 motor regulates activity-dependent neuronal survival by suppressing PARP-1 enzymatic activity.	KIF4A KIF4B	1.53e-05	3	79	2	16630823
Pubmed	Association of Y chromosome haplotypes with autism.	TBL1Y NLGN4Y	1.53e-05	3	79	2	19605777
Pubmed	CircKIF4A enhances osteosarcoma proliferation and metastasis by sponging MiR-515-5p and upregulating SLC7A11.	KIF4A KIF4B	1.53e-05	3	79	2	35579738
Pubmed	Neuroligin-4 is localized to glycinergic postsynapses and regulates inhibition in the retina.	NLGN4X NLGN4Y	1.53e-05	3	79	2	21282647
Pubmed	Compartmentalization of the SUMO/RNF4 pathway by SLX4 drives DNA repair.	CDCA2 ZNF384 FLNA EXOSC10 IPO7 KIF4A MCCC1	1.74e-05	357	79	7	37059091
Pubmed	Kinesin KIF4 regulates intracellular trafficking and stability of the human immunodeficiency virus type 1 Gag polyprotein.	KIF4A KIF4B	3.05e-05	4	79	2	18684836
Pubmed	DPP9 is a novel component of the N-end rule pathway targeting the tyrosine kinase Syk.	FLNA SYK	3.05e-05	4	79	2	27614019
Pubmed	Kif4 Is Essential for Mouse Oocyte Meiosis.	KIF4A KIF4B	3.05e-05	4	79	2	28125646
Pubmed	Mammalian tolloid proteinases: role in growth factor signalling.	TLL1 TLL2	3.05e-05	4	79	2	27391803
Pubmed	Four and half lim protein 2 (FHL2) stimulates osteoblast differentiation.	FLNA ITGB5	3.05e-05	4	79	2	16355270
Pubmed	Protein kinase B (AKT) regulates SYK activity and shuttling through 14-3-3 and importin 7.	IPO7 SYK	3.05e-05	4	79	2	27381982
Pubmed	Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism.	NLGN4X NLGN4Y	3.05e-05	4	79	2	12669065
Pubmed	Homodimerization and isoform-specific heterodimerization of neuroligins.	NLGN4X NLGN4Y	3.05e-05	4	79	2	22671294
Pubmed	Ultrasonic vocalizations in mouse models for speech and socio-cognitive disorders: insights into the evolution of vocal communication.	NLGN4X NLGN4Y	3.05e-05	4	79	2	20579107
Pubmed	Expression and activity-dependent changes of a novel limbic-serine protease gene in the hippocampus.	KLK8 KLK1	3.05e-05	4	79	2	7623137
Pubmed	Analysis of four neuroligin genes as candidates for autism.	NLGN4X NLGN4Y	3.05e-05	4	79	2	16077734
Pubmed	Neuroligins 3 and 4X interact with syntrophin-gamma2, and the interactions are affected by autism-related mutations.	NLGN4X NLGN4Y	3.05e-05	4	79	2	17292328
Pubmed	Genetic risk profiling and prediction of disease course in Crohn's disease patients.	DNAH12 HERC2 BSN	3.55e-05	28	79	3	19422935
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	USP34 ZNF384 FLNA SZT2 NLRC5 LTK HERC2 DNMBP ITGB5 SMURF2 HTT	3.97e-05	1105	79	11	35748872
Pubmed	Neuroligins and neurexins link synaptic function to cognitive disease.	NLGN4X NLGN4Y	5.07e-05	5	79	2	18923512
Pubmed	BCAP: the tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation.	PIK3AP1 SYK	5.07e-05	5	79	2	11163197
Pubmed	Gradient of integrin alpha 6A distribution in the myocardium during early heart development.	PECAM1 ITGB5	5.07e-05	5	79	2	7583004
Pubmed	Filamin B deficiency in mice results in skeletal malformations and impaired microvascular development.	FLNA PECAM1	5.07e-05	5	79	2	17360453
Pubmed	Multiple N-linked glycosylation sites critically modulate the synaptic abundance of neuroligin isoforms.	NLGN4X NLGN4Y	5.07e-05	5	79	2	37865312
Pubmed	Synapse formation: if it looks like a duck and quacks like a duck ...	NLGN4X NLGN4Y	5.07e-05	5	79	2	10996085
Pubmed	Mammalian BMP-1/Tolloid-related metalloproteinases, including novel family member mammalian Tolloid-like 2, have differential enzymatic activities and distributions of expression relevant to patterning and skeletogenesis.	TLL1 TLL2	5.07e-05	5	79	2	10479448
Pubmed	Pooled analysis of phosphatidylinositol 3-kinase pathway variants and risk of prostate cancer.	PIK3AP1 PIK3R3	5.07e-05	5	79	2	20197460
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	ASAP2 FAF2 IPO7 PIK3R3 TONSL ITPRID2 BSN	5.67e-05	430	79	7	35044719
Pubmed	The synaptic protein neuroligin-1 interacts with the amyloid β-peptide. Is there a role in Alzheimer's disease?	NLGN4X NLGN4Y	7.60e-05	6	79	2	21838267
Pubmed	Autism-associated neuroligin-4 mutation selectively impairs glycinergic synaptic transmission in mouse brainstem synapses.	NLGN4X NLGN4Y	7.60e-05	6	79	2	29724786
Pubmed	Alternative utrophin mRNAs contribute to phenotypic differences between dystrophin-deficient mice and Duchenne muscular dystrophy.	PECAM1 DMD	7.60e-05	6	79	2	29772070
Pubmed	Involvement of p72syk kinase, p53/56lyn kinase and phosphatidyl inositol-3 kinase in signal transduction via the human B lymphocyte antigen CD22.	PIK3R3 SYK	7.60e-05	6	79	2	8647200
Pubmed	Association of gene polymorphisms with chronic kidney disease in high- or low-risk subjects defined by conventional risk factors.	PDE4D PECAM1	7.60e-05	6	79	2	19424605
Pubmed	All kinesin superfamily protein, KIF, genes in mouse and human.	KIF26B KIF4A KIF4B	8.29e-05	37	79	3	11416179
Pubmed	Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor.	PIK3AP1 FLNA ASAP2 PIK3R3	9.19e-05	103	79	4	21706016
Pubmed	Genetic mapping in the mouse of Kif4, a gene encoding a kinesin-like motor protein.	KIF4A KIF4B	1.06e-04	7	79	2	9196009
Pubmed	Unusual chromatin status and organization of the inactive X chromosome in murine trophoblast giant cells.	KIF4A KIF4B	1.06e-04	7	79	2	23362347
Pubmed	Kinesin family in murine central nervous system.	KIF4A KIF4B	1.06e-04	7	79	2	1447303
Pubmed	Talin1 has unique expression versus talin 2 in the heart and modifies the hypertrophic response to pressure overload.	PECAM1 DMD	1.06e-04	7	79	2	23266827
Pubmed	HSPB7 interacts with dimerized FLNC and its absence results in progressive myopathy in skeletal muscles.	FLNA DMD	1.06e-04	7	79	2	26929074
Pubmed	Defective extraembryonic angiogenesis in mice lacking LBP-1a, a member of the grainyhead family of transcription factors.	UBP1 PECAM1	1.06e-04	7	79	2	15282311
Pubmed	Filamin A (FLNA) is required for cell-cell contact in vascular development and cardiac morphogenesis.	FLNA PECAM1	1.06e-04	7	79	2	17172441
Pubmed	A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome.	USP34 DLC1 KIF26B NLRC5 NBEA	1.07e-04	205	79	5	12040188
Pubmed	Rab11-FIP1 and Rab11-FIP5 Regulate pIgR/pIgA Transcytosis through TRIM21-Mediated Polyubiquitination.	FLNA NBEA MCCC1	1.13e-04	41	79	3	34638806
Pubmed	Sequential genome-wide CRISPR-Cas9 screens identify genes regulating cell-surface expression of tetraspanins.	USP34 FLNA VPS18 PLB1 NLGN4X KIF26B PIK3R3 NBEA DNAAF9	1.13e-04	832	79	9	36724073
Pubmed	A human MAP kinase interactome.	FLNA DLGAP1 ASAP2 KIF26B ITPRID2 HERC2 DMD	1.21e-04	486	79	7	20936779
Pubmed	Discovery and refinement of loci associated with lipid levels.	DAGLB TYW1B CUBN ABCA8 SNX5	1.23e-04	211	79	5	24097068
Pubmed	Cellular localization of the vesicular inhibitory amino acid transporter in the mouse and human retina.	DMD BSN	1.41e-04	8	79	2	12115694
Pubmed	Neuroligin-1 Signaling Controls LTP and NMDA Receptors by Distinct Molecular Pathways.	NLGN4X NLGN4Y	1.41e-04	8	79	2	30871858
Pubmed	Genetic utility of broadly defined bipolar schizoaffective disorder as a diagnostic concept.	AUTS2 BSN	1.41e-04	8	79	2	19567891
Pubmed	Genetic variations strongly influence phenotypic outcome in the mouse retina.	KIF4A KIF4B ITGB5	1.60e-04	46	79	3	21779340
Pubmed	Praja1, a novel gene encoding a RING-H2 motif in mouse development.	FLNA DMD	1.82e-04	9	79	2	9393880
Pubmed	Using mouse models of autism spectrum disorders to study the neurotoxicology of gene-environment interactions.	NLGN4X NLGN4Y	1.82e-04	9	79	2	23010509
Pubmed	Loss of the proteostasis factor AIRAPL causes myeloid transformation by deregulating IGF-1 signaling.	FAF2 HERC2	1.82e-04	9	79	2	26692333
Pubmed	Microglia ablation alleviates myelin-associated catatonic signs in mice.	NLGN4X NLGN4Y	1.82e-04	9	79	2	29252214
Pubmed	Structure of the Toll/Interleukin-1 Receptor (TIR) Domain of the B-cell Adaptor That Links Phosphoinositide Metabolism with the Negative Regulation of the Toll-like Receptor (TLR) Signalosome.	PIK3AP1 SYK	1.82e-04	9	79	2	27909057
Cytoband	12p12	ZNF384 BORCS5	2.25e-04	13	79	2	12p12
GeneFamily	Bone morphogenetic proteins\|Astacins	TLL1 TLL2	1.21e-04	6	52	2	894
GeneFamily	Kinesins\|Pleckstrin homology domain containing	KIF26B KIF4A KIF4B	3.12e-04	46	52	3	622
GeneFamily	X-linked mental retardation\|Angiotensin receptors	ZNF41 KIF4A DMD	4.75e-04	53	52	3	103
GeneFamily	Kallikreins	KLK8 KLK1	9.49e-04	16	52	2	616
GeneFamily	Zinc fingers ZZ-type\|Lysine acetyltransferases	HERC2 DMD	1.21e-03	18	52	2	91
GeneFamily	Ankyrin repeat domain containing	ASAP2 TONSL ANKS1B ANKRD30A	5.13e-03	242	52	4	403
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Gen_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	USP34 ASAP2 DLC1 USHBP1 PECAM1 ITPRID2	1.52e-06	200	79	6	dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCell	saliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_B-B_cell-B_c01-TCL1A\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	FHAD1 PDE4D DNAH12 NLGN4Y CUBN	1.23e-05	168	79	5	9a8709d34865cfa668d8f3335dc34fc86fc32482
ToppCell	343B-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_1\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	PECAM1 ANKS1B NLRC5 LTK DNMBP	1.38e-05	172	79	5	d65ffff3e341af34a043a0d802d7ba4b69de36e9
ToppCell	5'-Adult-Appendix-Mesenchymal-myocytic-myofibroblast\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FLNA DLGAP1 PDE4D ZNF334 DMD	1.59e-05	177	79	5	e65c0568dc5852108e9802273499bc7cf88fafab
ToppCell	PBMC-Convalescent-Lymphocyte-B-B_cell-B_intermediate-B_intermediate-1\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	DLGAP1 DNAH12 SYK DMD KLK1	1.63e-05	178	79	5	812e261d9cbdc74fafe3c5c3422151c1cfacb22d
ToppCell	Control-Epithelial_cells-AT2\|Control / group, cell type (main and fine annotations)	DLGAP1 PDE4D DLC1 AUTS2 DMBT1	1.72e-05	180	79	5	198b19e7910b4a8cc7e820c525ab357c7f99f578
ToppCell	5'-Adult-SmallIntestine-Mesenchymal-myocytic-myofibroblast\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FLNA DLGAP1 ZNF334 ANKS1B DMD	1.77e-05	181	79	5	fc51468c74534b60b4e786bd512d0f1c5dc05de7
ToppCell	droplet-Kidney-nan-3m-Endothelial-Pecam____kidney_capillary_endothelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ASAP2 DLC1 USHBP1 PECAM1 KLK8	1.81e-05	182	79	5	f4a5f1c3a04c0566eb96607dab7a0d9a5ebc3fd1
ToppCell	RA-13._Vascular_Smooth_Muscle\|World / Chamber and Cluster_Paper	FLNA PDE4D DLC1 ANKS1B DMD	1.86e-05	183	79	5	cae2ee08f985a6f005b4b8e959e465350315156a
ToppCell	droplet-Lung-21m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l25\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ASAP2 PIK3R3 PECAM1 ITPRID2 CUBN	1.91e-05	184	79	5	087666ba949b129c53d7ace40f9e543e3875a7de
ToppCell	COVID-19_Severe-gd_T\|COVID-19_Severe / Disease condition and Cell class	PIK3AP1 PPP4R3B FHAD1 FLNA PIK3R3	1.91e-05	184	79	5	791f1bcb954aadc63d4117c400537d036f68734d
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2-D231\|Adult / Lineage, Cell type, age group and donor	DLGAP1 PDE4D DLC1 AUTS2 DMBT1	2.17e-05	189	79	5	dab54a52358f66a8a9460cd6089a06c5fa7e7a5d
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DLC1 KIF26B AUTS2 DMD ABCA8	2.29e-05	191	79	5	107113b930d9ad171f1b2aa20df4567c94fae7d8
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DLC1 KIF26B AUTS2 DMD ABCA8	2.29e-05	191	79	5	bc353a79a1d11ca52bba5e3874a80d432e1a7715
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW23-Stem_cells\|GW23 / Sample Type, Dataset, Time_group, and Cell type.	CDCA2 PIK3AP1 NLRC5 KIF4A DNMBP	2.34e-05	192	79	5	1fc95f7e1a71683c8176693c79ee19eabae8b203
ToppCell	Epithelial-alveolar_epithelial_cell_type_2\|World / Lineage, Cell type, age group and donor	PDE4D DLC1 AUTS2 MCCC1 DMBT1	2.34e-05	192	79	5	58c3737be7acce39fd2b91d70d6d7b2bbaa4f710
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2-D122\|Adult / Lineage, Cell type, age group and donor	PDE4D DLC1 TBL1Y AUTS2 MCCC1	2.34e-05	192	79	5	06013a07e3a873b1d1c0451643c528593ac32a9c
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW23-Stem_cells-Stem_cells\|GW23 / Sample Type, Dataset, Time_group, and Cell type.	CDCA2 PIK3AP1 NLRC5 KIF4A DNMBP	2.34e-05	192	79	5	378b994d8879512e2769760cfa900aebde90a3e2
ToppCell	droplet-Lung-30m-Endothelial-venous_endothelial-vein_endothelial_cell-vein_endothelial_cell\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ASAP2 DLC1 USHBP1 TLL1 PECAM1	2.34e-05	192	79	5	452d54f0aca8657722d7ac61e8422921d08c06b3
ToppCell	droplet-Lung-30m-Endothelial-venous_endothelial-vein_endothelial_cell\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ASAP2 DLC1 USHBP1 TLL1 PECAM1	2.34e-05	192	79	5	7ddaca206599603d4d0b2afb73ed2850225d277d
ToppCell	droplet-Lung-30m-Endothelial-venous_endothelial\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ASAP2 DLC1 USHBP1 TLL1 PECAM1	2.34e-05	192	79	5	bf0b996aeedc34a79c71df3379ec9c1aabe06a8c
ToppCell	nucseq-Epithelial-Epithelial_Alveolar-AT2-AT2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	PDE4D DLC1 AUTS2 MCCC1 DMBT1	2.40e-05	193	79	5	fd4d3c0d7caf8a2fff5b3d901fc28d19a8163cdf
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2\|Adult / Lineage, Cell type, age group and donor	PDE4D DLC1 AUTS2 MCCC1 DMBT1	2.40e-05	193	79	5	738f4f0a9ddde2432b429ab46838e353b1790589
ToppCell	nucseq-Epithelial-Epithelial_Alveolar-AT2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	PDE4D DLC1 AUTS2 MCCC1 DMBT1	2.40e-05	193	79	5	f3cc7cfdbc164a4ed42f87647111522b7d393bcb
ToppCell	10x_3'_v2v3-Non-neoplastic-Lymphoid-CD4/CD8-CD8_NK_sig-D\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	FLNA PDE4D BORCS5 AUTS2 PSD4	2.59e-05	196	79	5	c57a95f8b4d8d6334f269d3c16246684f4222a3e
ToppCell	367C-Fibroblasts-Fibroblast-G-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	DLGAP1 NLGN4X FIBCD1 PSD4	2.69e-05	97	79	4	a1279377bf0ee5662db8b9303f5f1fd418dee6df
ToppCell	367C-Fibroblasts-Fibroblast-G\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	DLGAP1 NLGN4X FIBCD1 PSD4	2.69e-05	97	79	4	12cbd03b33e76e5e471bbee2a9c11f27e8b21123
ToppCell	mLN-T_cell-cycling_gd_T\|T_cell / Region, Cell class and subclass	CDCA2 PIK3AP1 KIF26B SYK KIF4A	2.78e-05	199	79	5	c81a194f8c2f120c6c4d74857912865a3c2fe1e7
ToppCell	Tracheal-NucSeq\|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations	USP34 PDE4D AUTS2 NBEA DMD	2.78e-05	199	79	5	94b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCell	LPS_IL1RA-Endothelial-Endothelial\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	ASAP2 DLC1 USHBP1 PECAM1 ITPRID2	2.85e-05	200	79	5	72ea9882a8ed26fa1534aeb6ba0d1897dccc20c5
ToppCell	390C-Endothelial_cells-Endothelial-B_(Artery)-\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	PIK3R3 ITPRID2 CUBN ITGB5 SMURF2	2.85e-05	200	79	5	c32ad15dede3f879007c0b856f2fed1f5b058103
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Activated_Gen_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	ASAP2 DLC1 PECAM1 ITPRID2 SMURF2	2.85e-05	200	79	5	2d07237022b409c4fac6fcf99b68c8affb3007cd
ToppCell	LPS_only-Endothelial-Endothelial-Gen_Cap\|LPS_only / Treatment groups by lineage, cell group, cell type	ASAP2 DLC1 USHBP1 PECAM1 NRROS	2.85e-05	200	79	5	eb94a5111ef0e903ee5be9f7efe571b4e6d5fce1
ToppCell	LPS_IL1RA-Endothelial\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	ASAP2 DLC1 USHBP1 PECAM1 ITPRID2	2.85e-05	200	79	5	5c092b2ecc081b5d04476c56333c338cd89ab984
ToppCell	LPS_only-Endothelial\|LPS_only / Treatment groups by lineage, cell group, cell type	DLC1 USHBP1 PECAM1 ITPRID2 NRROS	2.85e-05	200	79	5	81e76508c9050d533853d5fd2f3097b27613d836
ToppCell	Tracheal-NucSeq-Epithelial-Epi_submucosal-gland-SMG_Serous\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	PIK3AP1 DLGAP1 ANKS1B DMBT1 DMD	2.85e-05	200	79	5	7c2d499af60654b7b28f172ac2c914ad49fb74b4
ToppCell	Neuronal-Inhibitory-iB-iB_4(SST)\|Neuronal / cells hierarchy compared to all cells using T-Statistic	DLGAP1 KIF26B TLL2 AUTS2 ITGB5	2.85e-05	200	79	5	347a510755374c6a66acee326565dfc447993f18
ToppCell	LPS_anti-TNF-Endothelial-Endothelial-Gen_Cap\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	ASAP2 DLC1 USHBP1 PECAM1 ITPRID2	2.85e-05	200	79	5	a2b9d1cd291d17abddc3ee2e242121412c864b8b
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW10-Mesenchymal\|GW10 / Sample Type, Dataset, Time_group, and Cell type.	PIK3AP1 USHBP1 FIBCD1 SYK PSD4	2.85e-05	200	79	5	5c638c80661017c85f9390f1b398ac7728c8f001
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW10-Mesenchymal-BMP_responsible_cell\|GW10 / Sample Type, Dataset, Time_group, and Cell type.	PIK3AP1 USHBP1 FIBCD1 SYK PSD4	2.85e-05	200	79	5	604a88633d4162337e394155c7346dbdef8b9f5a
ToppCell	390C-Endothelial_cells-Endothelial-B_(Artery)\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	PIK3R3 ITPRID2 CUBN ITGB5 SMURF2	2.85e-05	200	79	5	8a2c6c53a39fab86750526083f7254b7413b29af
ToppCell	LPS_only-Endothelial-Endothelial\|LPS_only / Treatment groups by lineage, cell group, cell type	DLC1 USHBP1 PECAM1 ITPRID2 NRROS	2.85e-05	200	79	5	4bb609a284d4e6066f17470a1736076aa4a1f84c
ToppCell	343B-Lymphocytic-CD8+_Cytotoxic_T-cell\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	EXOSC10 ANKS1B NLRC5 LTK	1.32e-04	146	79	4	bb7bf20245d93c8812920dd0debbf1ed00add378
ToppCell	facs-Lung-3m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CDCA2 DLGAP1 NBEA CUBN	1.39e-04	148	79	4	5983c4546f527a0b599cfcbd8a6cb937a1d6f895
ToppCell	LPS-IL1RA+antiTNF-Unknown-Endothelial-Myofibroblast\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SIN3B VPS18 NLGN4Y APBA2	1.62e-04	154	79	4	16fdafb5c64d2db321554f87129a962d113f1668
ToppCell	E18.5-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_B\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	M1AP SYK BSN PSD4	1.71e-04	156	79	4	55ba43cec9d79f309e9f633a6469cf03bb621e64
ToppCell	E18.5-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_B-B\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	M1AP SYK BSN PSD4	1.71e-04	156	79	4	44ff0acdd5cc3575d6c24a1c2ba11cd9f55359d1
ToppCell	356C-Fibroblasts-Fibroblast-B_(Myofibroblast)\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	DNAH12 KIF26B KIF4A BSN	1.75e-04	157	79	4	f6210be2362d833c6d869ff921188bfc85dda11d
ToppCell	356C-Fibroblasts-Fibroblast-B_(Myofibroblast)-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	DNAH12 KIF26B KIF4A BSN	1.75e-04	157	79	4	43a6b423fd70479822a564ff4225a1e4951ae5ed
ToppCell	TCGA-Kidney-Primary_Tumor-Renal_Cell_Carcinoma-Kidney_Clear_Cell_Renal_Carcinoma-1\|TCGA-Kidney / Sample_Type by Project: Shred V9	CDCA2 USHBP1 TLL1 PECAM1	1.93e-04	161	79	4	6cacae4a759ace763597ee394cff498dc5d96f74
ToppCell	10x5'-bone_marrow-Lymphocytic_B-ABC_aged-B_memory\|bone_marrow / Manually curated celltypes from each tissue	NLGN4X SYK NRROS KLK1	2.07e-04	164	79	4	746833f74095c0f25ce76baf1069f1848c231933
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_G2M\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CDCA2 TONSL KIF4A DMBT1	2.07e-04	164	79	4	1642a67c66eeb77a218e7814e3cfe517d9822955
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CDCA2 TONSL KIF4A DMBT1	2.07e-04	164	79	4	25758fb8112baf296264122d5d4121f1ebb3d0fa
ToppCell	LV-16._Neuronal\|World / Chamber and Cluster_Paper	ASAP2 DLC1 NLGN4X ABCA8	2.12e-04	165	79	4	6ed52cb756d21addf46c7f6c457458b01339fe04
ToppCell	facs-GAT-Fat-3m-Lymphocytic-CD8-positive,_alpha-beta_T_cell\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE4D FIBCD1 KLK8 NLRC5	2.16e-04	166	79	4	3695407e4638f3c18fbff63daba52baa9256c429
ToppCell	Control\|World / group, cell type (main and fine annotations)	DLGAP1 DLC1 ANKS1B DMBT1	2.27e-04	168	79	4	a3511faf2cd2c2b9c8363c8b99da3f3609c43ed6
ToppCell	5'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FHAD1 DNAH12 DMD CUBN	2.32e-04	169	79	4	8bca402e144819cb9a8d431d6bf9429be2fff6d6
ToppCell	LV-16._Neuronal\|LV / Chamber and Cluster_Paper	ASAP2 DLC1 NLGN4X ABCA8	2.32e-04	169	79	4	a8fc8ab0f0757e939e213efb61c03cfe390bf7d2
ToppCell	10x5'-Liver-Lymphocytic_B-ABC_aged-B_memory\|Liver / Manually curated celltypes from each tissue	NLGN4X SYK KLK1 IGLV4-3	2.42e-04	171	79	4	eb47f4a09a630ed14a0898377039ed50ef7cc292
ToppCell	3'-Child09-12-SmallIntestine-Hematopoietic-T_cells-Th1\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PDE4D ANKS1B LTK MCCC1	2.48e-04	172	79	4	c0c9a3f5b5fb942b049bc159fd9f21b5b706edd2
ToppCell	Adult-Endothelial-endothelial_cell_of_bronchial_vessel\|Adult / Lineage, Cell type, age group and donor	NLGN4Y TLL1 PIK3R3 PECAM1	2.48e-04	172	79	4	ad4ffdb3fc0c560a9cbaa2bc048476cbc43e8fd6
ToppCell	facs-Pancreas-Exocrine-3m-Epithelial-pancreatic_acinar_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ITPRID2 DMBT1 KLK1 CBS	2.53e-04	173	79	4	c62e3ffed55bbb00dcaef6da0aab8446f3f55085
ToppCell	facs-Pancreas-Exocrine-3m-Epithelial-pancreatic_acinar_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ITPRID2 DMBT1 KLK1 CBS	2.53e-04	173	79	4	f612d4ea9ab8dcde475f4118bca3e49be786e7fa
ToppCell	facs-Pancreas-Exocrine-18m-Epithelial-pancreatic_acinar_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ITPRID2 DMBT1 KLK1 CBS	2.59e-04	174	79	4	165e14cad57e90aa247dcecfaa3c2e8ff2a470ad
ToppCell	PBMC-Convalescent-Lymphocyte-B-B_cell-B_intermediate-B_intermediate-10\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CDCA2 NLGN4Y SYK DNMBP	2.59e-04	174	79	4	59ccc5a82507463e0a316ba6286cb25ec1a4091b
ToppCell	facs-Pancreas-Exocrine-18m-Epithelial-pancreatic_acinar_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ITPRID2 DMBT1 KLK1 CBS	2.59e-04	174	79	4	4289dfc7613db4bb3d706b9b65d06e84c0c53558
ToppCell	facs-Pancreas-Exocrine-18m-Epithelial\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PIK3AP1 DMBT1 KLK1 CBS	2.65e-04	175	79	4	3f1b2e23fec953148fb0711e523c463adb07dca4
ToppCell	COVID-matDC-\|COVID / Condition, Cell_class and T cell subcluster	ASAP2 ZNF334 NLGN4Y ANKS1B	2.65e-04	175	79	4	db5e170411dfa62074c4b8311bb8c589d1c4279b
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Neuronal-interneuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DLGAP1 ANKS1B DMBT1 KLK1	2.65e-04	175	79	4	65571d775d26a40e979dbf290a8e4320c0d9fb3f
ToppCell	COVID-matDC\|COVID / Condition, Cell_class and T cell subcluster	ASAP2 ZNF334 NLGN4Y ANKS1B	2.65e-04	175	79	4	e2b638109c9ffd10430e6e134035622b7605ce23
ToppCell	3'-Child09-12-SmallIntestine-Mesenchymal-myocytic-myofibroblast_(RSPO2+)\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FHAD1 FLNA NBEA DMD	2.70e-04	176	79	4	a8875b4ba4abf6625cdeb67bf544ce1573c59060
ToppCell	droplet-Pancreas-Exocrine-18m-Endothelial-endothelial_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DLC1 USHBP1 TLL1 PECAM1	2.70e-04	176	79	4	eb63eb2c301e785196ccadac74a2940b2c524c62
ToppCell	CV-Severe-7\|Severe / Virus stimulation, Condition and Cluster	DAGLB SIN3B NLGN4Y HTT	2.76e-04	177	79	4	82fdd6185b368f54f03de389427cbe3071d21a99
ToppCell	ILEUM-inflamed-(9)_Enteric_neurons\|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	ASAP2 NLGN4X ANKRD30A ABCA8	2.82e-04	178	79	4	d9142151819afb0dc22bfb32a9c9dba5f553067d
ToppCell	356C-Lymphocytic-CD4_T-cell-Treg_cell_2\|356C / Donor, Lineage, Cell class and subclass (all cells)	TONSL ANKS1B NRROS UHRF2	2.82e-04	178	79	4	8b939659f713eea50a1a6e28b571f680ca0b4c12
ToppCell	kidney_cells-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell__prolif\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SIN3B DLC1 USHBP1 PECAM1	2.82e-04	178	79	4	375156ba1c7b8592bf733c75f24968161f7cfa09
ToppCell	ILEUM-inflamed-(9)_Neuro_cell\|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	ASAP2 NLGN4X ANKRD30A ABCA8	2.82e-04	178	79	4	611504b0a9e6318b18fba83787b03f9245c82252
ToppCell	droplet-Bladder-nan-24m-Epithelial-endothelial_cell\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DLGAP1 APBA2 KLK8 ANKS1B	2.88e-04	179	79	4	3d6bb3cfe89d60f2f00aead9341f9967e5313763
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PIK3AP1 MASP1 PDE4D CUBN	2.88e-04	179	79	4	58ae5a97fe2a14e1c6fdeb886397eb06fdaf0428
ToppCell	facs-Pancreas-Exocrine-18m\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PIK3AP1 DMBT1 KLK1 CBS	2.88e-04	179	79	4	bbfbfb32773346080127055b5aafa36bbf7d0942
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DLGAP1 PDE4D ANKS1B CUBN	3.01e-04	181	79	4	9542c19edc9bd2cba68c01c2a8407705398e3011
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DLGAP1 PDE4D ANKS1B CUBN	3.01e-04	181	79	4	8f04f8cac5d705dc5f6cf6f4516d6e45b0aa4ae5
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	M1AP PDE4D KIF26B SYK	3.01e-04	181	79	4	b7c85fbef3c06d5dc32a2a58f8d3dfabf1d79d9f
ToppCell	droplet-Limb_Muscle-nan-21m-Macroglial-nan\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DLGAP1 KLK8 ANKS1B KIF4A	3.07e-04	182	79	4	a512863304fad80acaab60a8c6107eb7c9cbac99
ToppCell	facs-Pancreas-Exocrine\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PIK3AP1 DMBT1 KLK1 CBS	3.07e-04	182	79	4	45faefd7cbeac84d2c58650530b902af6ce921f8
ToppCell	10x5'-Liver-Lymphocytic_T_CD4/8-lo-Cycling_T\|Liver / Manually curated celltypes from each tissue	CDCA2 USHBP1 KIF4A KIF4B	3.07e-04	182	79	4	81557cdc88777f3bd4e1dd18a760b08fc29122ef
ToppCell	COVID-19-Heart-Fib_+_EC_+_Pericyte\|COVID-19 / Disease (COVID-19 only), tissue and cell type	DLC1 NLGN4X ANKS1B ABCA8	3.07e-04	182	79	4	fbd5e332df73bf7141c822fa67b76367dc962017
ToppCell	RA-13._Vascular_Smooth_Muscle\|RA / Chamber and Cluster_Paper	FLNA DLC1 ANKS1B DMD	3.14e-04	183	79	4	818fd886e0188091310825f9145fa53328f2c979
ToppCell	TCGA-Liver-Primary_Tumor-Hepatocellular_Carcinoma-Hepatocellular_Carcinoma-5\|TCGA-Liver / Sample_Type by Project: Shred V9	CDCA2 EXOSC10 TONSL KIF4A	3.14e-04	183	79	4	f604a8b62c7088fad8365dbf8d910fc980bd3ba8
ToppCell	356C-Lymphocytic-CD4_T-cell-Treg_cell_2\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	TONSL ANKS1B NRROS UHRF2	3.14e-04	183	79	4	f142b320023eef00b48d4820c46214c9794d37e7
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb-3m-Lymphocytic-B_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PIK3AP1 SYK NRROS SNX5	3.14e-04	183	79	4	20f7b6ec2462032eda957a893ca76d5a5a01333d
ToppCell	Mild/Remission-B_intermediate-10\|Mild/Remission / disease group and sub_cluster of B and Plasma cells(res = 0.5)	FLNA SYK NRROS DNMBP	3.14e-04	183	79	4	278064c9f0582463b83bf156d34e77f60187613b
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FHAD1 NLGN4Y DMD ITGB5	3.20e-04	184	79	4	689a8af81a79a4bb3123cfa01958c953eab5de98
ToppCell	Mild/Remission-B_intermediate-6\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	FLNA SYK NRROS KLK1	3.20e-04	184	79	4	3d4864605c812862cf8926e02370eea3b8ccf32f
ToppCell	COVID-19-Epithelial_cells-AT2\|COVID-19 / group, cell type (main and fine annotations)	DLGAP1 PDE4D AUTS2 DMBT1	3.20e-04	184	79	4	369b82f793deab672204558ae4e112cfa5aa9ccc
ToppCell	3'-GW_trimst-2-LargeIntestine-Neuronal-Glial_immature\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NLGN4X ANKS1B DMD ABCA8	3.20e-04	184	79	4	226ccac00ac1c3a0ad7283785fd14312320e0ca6
ToppCell	ILEUM-inflamed-(1)_T_cell-(1)_CD8_Trm\|(1)_T_cell / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	PDE4D PIK3R3 APBA2 AUTS2	3.20e-04	184	79	4	cef3ee2a4a0af961aa3b4c92150d423e841ae8c1
ToppCell	356C-Lymphocytic-CD4_T-cell-Treg_cell_2\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	TONSL ANKS1B NRROS UHRF2	3.27e-04	185	79	4	e06a784a297f357f3f8e761c24fa70722048ab42
ToppCell	droplet-Limb_Muscle-nan-21m-Macroglial\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DLGAP1 KLK8 ANKS1B KIF4A	3.27e-04	185	79	4	3d1353dbcb60e2531ef67e1bd218b7bc4d7c7c9b
ToppCell	droplet-Limb_Muscle-nan-21m-Macroglial-Schwann_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DLGAP1 KLK8 ANKS1B KIF4A	3.27e-04	185	79	4	995a8ddc3fd8e6879d8b5de8cbdefe232d34833b
Disease	coronary artery disease (is_implicated_in)	TLL1 PECAM1 CUBN CBS	1.25e-04	100	75	4	DOID:3393 (is_implicated_in)
Disease	epithelial cell adhesion molecule measurement	PPP4R3B USP34 MTIF2	3.01e-04	51	75	3	EFO_0010574
Disease	diffuse plaque measurement	FHAD1 DLC1 KIF26B SYK ANKS1B KIF4B DMBT1 ABCA8	6.77e-04	758	75	8	EFO_0010699
Disease	synophrys measurement	AUTS2 HERC2 HTT	7.02e-04	68	75	3	EFO_0007906
Disease	ovarian carcinoma	DLC1 USHBP1 TONSL AUTS2 DMD	1.37e-03	321	75	5	EFO_0001075
Disease	eye color	PDE4D APBA2 HERC2	1.58e-03	90	75	3	EFO_0003949
Disease	Colorectal Carcinoma	VPS18 DLC1 NLGN4X DMD CUBN UHRF2 ABCA8	2.05e-03	702	75	7	C0009402

Protein segments in the cluster

Peptide	Gene	Start	Entry
ALHLALQYSEHCEEA	USHBP1	341	Q8N6Y0
SHTHENENYLLHENC	ANKRD30A	1091	Q9BXX3
NHYHACAADDDFDTD	DLGAP1	746	O14490
YAEAHCDFVHQALEQ	DNMBP	1186	Q6XZF7
YLAHSAHPVDTDECQ	APBA2	121	Q99767
EAHDQEEDGHYCASK	APBA2	176	Q99767
EAHTDVYHNLDENSQ	DMD	2746	P11532
SQDLLEDNSHLYRHC	ANGEL2	176	Q5VTE6
RDQCHLGQEEDVYHT	PIK3AP1	501	Q6ZUJ8
QHVEVFCYASQDLHE	CHM	96	P24386
SYLDHVHALEEANAD	KRT26	96	Q7Z3Y9
EDLCHTISDHYLDNL	ANKS1B	346	Q7Z6G8
DELETNQQHFHALCH	M1AP	341	Q8TC57
LENHTRQADEDYSHD	KLK1	106	P06870
DTYDASHECELELVH	MTIF2	536	P46199
IHYSYNEEKDEDHCS	HERC2	1351	O95714
ADLCHYHSQESDGLV	SYK	86	P43405
HDRTYHFQAEDEQEC	ASAP2	371	O43150
SHQQDCDEDDHRNSH	KIF26B	666	Q2KJY2
LDDSHCVVSDSEAYH	BSN	3561	Q9UPA5
DIAQGCHYLEENHFI	LTK	626	P29376
GLKRAYACHAEHEND	IPO7	871	O95373
YACHAEHENDSDDDD	IPO7	876	O95373
HADVAYHNNIHAADV	PDE4D	456	Q08499
DVEYQCVADNCHSHA	PECAM1	471	P16284
HHYSSDRENDRNLCQ	AUTS2	146	Q8WXX7
YHEFLECAHEACNVH	DNAH12	1491	Q6ZR08
HHFSDVVDQCLDEYN	DNAH12	2206	Q6ZR08
ACENLENTEGLHHLY	PPP4R3B	181	Q5MIZ7
EANHLHESDAQIENC	ITPRID2	121	P28290
HDGQCHLNEANEYTA	ITGB5	296	P18084
CHHLEELDLSNNQFD	NLRC5	1521	Q86WI3
QELSHALYQHDAACR	PRPF19	101	Q9UMS4
QLEHDHECESLQAHD	NLGN4Y	736	Q8NFZ3
FEEQCHTQEQHSKEY	PIK3R3	226	Q92569
SLEHHDDCNKDYLEI	CUBN	636	O60494
DLEHHINCSTDYLEL	CUBN	1326	O60494
NCQEFAVDLEHHSYR	EXOSC10	306	Q01780
DNHHALIEYNEAECS	FHAD1	36	B1AJZ9
LFCDYVCQNLHDSEH	HTT	1901	P42858
SQEADLDAELENCHH	DAGLB	266	Q8NCG7
LDAELENCHHYMQFA	DAGLB	271	Q8NCG7
HEAEIVEGENHTYCI	FLNA	2186	P21333
YQDHLHQCAEAVAFD	BORCS5	96	Q969J3
AHYDTTADEILQQCD	CBS	231	P35520
NLHFHCMTENEYEDE	DNAAF9	126	Q5TEA3
YHGEDQSDQCLKEHA	MCCC1	181	Q96RQ3
REDEELSCDHYCHNY	MASP1	146	P48740
ESLQEHCNNLYDDDG	CDCA2	341	Q69YH5
DRDSDHSENNCAAFY	FIBCD1	391	Q8N539
IEDLKYCSEHSVNEH	KIF4A	1041	O95239
IEDLKYCSEHSVNEH	KIF4B	1041	Q2VIQ3
HPCYNSSDVEDHNHD	KLK8	106	O60259
LKLEAHHNCSFDYVE	DMBT1	1811	Q9UGM3
QLEHDHECESLQAHD	NLGN4X	736	Q8N0W4
CLSENYEETAAALHA	NRROS	116	Q86YC3
YKEAANHCALLQEHA	SZT2	1286	Q5T011
IEQHQECAYDHLEVF	TLL1	821	O43897
LQSDDEAEYHCGESH	IGLV4-3	101	A0A075B6K6
DVHKHAEFESQCAQY	NBEA	1996	Q8NFP9
YLHGDDHQDSDEFCR	FAF2	176	Q96CS3
QHRSHENCLDAAADD	PSD4	926	Q8NDX1
EHDAKSHSYDCTVDL	SHLD3	76	Q6ZNX1
NEIESVYDEHQEQHS	SIN3B	626	O75182
NDLCHYCENPEAHLA	PLB1	1211	Q6P1J6
DDSADYQHFLQDCVD	DLC1	1316	Q96QB1
NATDEEIDHYCKHSE	SIX6OS1	56	Q8N1H7
HKDHTAHCYETNEDV	ABCA8	151	O94911
DHTFCVEHNAYGEII	SMURF2	546	Q9HAU4
SNSDCVAADEDVIYH	UHRF2	196	Q96PU4
HNCHRAYTDAASLEV	ZNF384	406	Q8TF68
IHESHHNGDFCYQDV	ZNF761	76	Q86XN6
HNGDFCYQDVDKDIH	ZNF761	81	Q86XN6
NTKENLYECSEHGHA	ZNF334	511	Q9HCZ1
THLDIYDHCQSRDAL	TONSL	116	Q96HA7
AYHCQHEAYEEALAV	VPS18	571	Q9P253
FEIEQHQECAYDHLE	TLL2	821	Q9Y6L7
SHKNVADDYIHTAAC	SNX5	236	Q9Y5X3
DACVHDLQAHSKEIY	TBL1Y	391	Q9BQ87
HCHVSDVEVQEHYDS	U2AF1L4	66	Q8WU68
HTCHNEHSNLEELFQ	TMEM87B	96	Q96K49
NENGEYTDHLHSASC	UBP1	216	Q9NZI7
ENAKTGANSCEHDHY	ZNF41	276	P51814
HCLVEDSECYDDALH	USP34	1016	Q70CQ2
AEDEVVICPYDSNHH	SNRNP48	51	Q6IEG0
EYEIACEHEHSNCLL	TYW1B	576	Q6NUM6