Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionguanyl-nucleotide exchange factor activity

DENND5B DOCK8 DOCK7 KIAA1755 PLCD4 DENND4C

4.98e-05231576GO:0005085
DomainNPIP

NPIPA1 NPIPA3 NPIPA7 NPIPA2

7.63e-0814574IPR009443
DomainARM-type_fold

FOCAD DOCK8 RTTN ATM ARID1A TRRAP GCN1

7.40e-05339577IPR016024
DomainDUF3398

DOCK8 DOCK7

1.36e-046572PF11878
DomainFAT

ATM TRRAP

1.36e-046572PS51189
DomainFATC

ATM TRRAP

1.36e-046572PS51190
DomainFAT

ATM TRRAP

1.36e-046572PF02259
DomainPIK-rel_kinase_FAT

ATM TRRAP

1.36e-046572IPR003151
DomainFATC_dom

ATM TRRAP

1.36e-046572IPR003152
DomainDOCK_C/D_N

DOCK8 DOCK7

1.36e-046572IPR021816
DomainPIK_FAT

ATM TRRAP

1.36e-046572IPR014009
DomainFATC

ATM TRRAP

1.36e-046572SM01343
DomainDOCK_C

DOCK8 DOCK7

4.94e-0411572IPR010703
DomainDHR-1_domain

DOCK8 DOCK7

4.94e-0411572IPR027007
DomainDHR_2

DOCK8 DOCK7

4.94e-0411572PS51651
DomainDHR_1

DOCK8 DOCK7

4.94e-0411572PS51650
DomainDOCK-C2

DOCK8 DOCK7

4.94e-0411572PF14429
DomainDHR-2

DOCK8 DOCK7

4.94e-0411572IPR027357
DomainDHR-2

DOCK8 DOCK7

4.94e-0411572PF06920
DomainDOCK

DOCK8 DOCK7

4.94e-0411572IPR026791
DomainUDENN

DENND5B DENND4C

1.07e-0316572PS50946
DomainDDENN

DENND5B DENND4C

1.07e-0316572PS50947
DomainDENN

DENND5B DENND4C

1.07e-0316572SM00799
Domain-

ATM TRRAP

1.07e-03165721.10.1070.11
DomaindDENN

DENND5B DENND4C

1.07e-0316572SM00801
DomainDENN

DENND5B DENND4C

1.07e-0316572PF02141
DomaindDENN_dom

DENND5B DENND4C

1.07e-0316572IPR005112
DomainuDENN_dom

DENND5B DENND4C

1.07e-0316572IPR005113
DomaindDENN

DENND5B DENND4C

1.07e-0316572PF03455
DomainDENN

DENND5B DENND4C

1.07e-0316572PS50211
DomainDENN_dom

DENND5B DENND4C

1.07e-0316572IPR001194
DomainPI3Kc

ATM TRRAP

1.07e-0316572SM00146
DomainPI3/4_kinase_cat_dom

ATM TRRAP

1.36e-0318572IPR000403
DomainPI3_PI4_kinase

ATM TRRAP

1.36e-0318572PF00454
DomainPI3_4_KINASE_3

ATM TRRAP

1.36e-0318572PS50290
DomainPI3_4_KINASE_1

ATM TRRAP

1.36e-0318572PS00915
DomainPI3_4_KINASE_2

ATM TRRAP

1.36e-0318572PS00916
DomainARM-like

DOCK8 RTTN ARID1A TRRAP GCN1

1.38e-03270575IPR011989
Domain-

RTTN ARID1A TRRAP GCN1

4.69e-032225741.25.10.10
Domainzf-C3HC4

MID1 OBI1 RNF43 RING1

4.77e-03223574PF00097
Pubmed

Novel retinal and cone photoreceptor transcripts revealed by human macular expression profiling.

NPIPA1 NPIPA3 NPIPA2

2.16e-08462318055785
Pubmed

Activator-Mediator binding regulates Mediator-cofactor interactions.

ATM TRRAP GCN1

8.81e-071162320534441
Pubmed

Positive selection of a gene family during the emergence of humans and African apes.

NPIPA1 NPIPA8

3.13e-06262211586358
Pubmed

Overexpression of the novel senescence marker β-galactosidase (GLB1) in prostate cancer predicts reduced PSA recurrence.

GLB1 KLK3

3.13e-06262225876105
Pubmed

The clinical phenotype of YWHAE-NUTM2B/E positive pediatric clear cell sarcoma of the kidney.

NUTM2E NUTM2B

9.37e-06362226542179
Pubmed

XRRA1 Targets ATM/CHK1/2-Mediated DNA Repair in Colorectal Cancer.

XRRA1 ATM

1.87e-05462229082250
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

PTK2B KARS1 NRDC DOCK8 MINK1 DOCK7 KIAA1549 ARID1A RHOT1 SCAI WDR47

4.06e-051431621137142655
Pubmed

Tel2 regulates the stability of PI3K-related protein kinases.

ATM TRRAP

1.39e-041062218160036
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

PTK2B RADIL MINK1 DOCK7 BOD1L1 FAM117B OBI1 DENND4C

1.42e-0486162836931259
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

FOCAD PIKFYVE RADIL RTTN ARID1A TRRAP GCN1 RNF43 ADCY9

1.43e-04110562935748872
Pubmed

Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.

RADIL DOCK8 DOCK7 KIAA1549 ARID1A DENND4C

1.44e-0444662624255178
Pubmed

Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly.

ATM TRRAP

1.70e-041162220427287
Pubmed

Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.

PLCD4 BOD1L1 ARID1A TRRAP GCN1 HYDIN

1.89e-0446962627634302
Pubmed

E3 ubiquitin ligase MID1 ubiquitinates and degrades type-I interferon receptor 2.

MID1 RING1

2.04e-041262235794827
Pubmed

An ATM/TRIM37/NEMO Axis Counteracts Genotoxicity by Activating Nuclear-to-Cytoplasmic NF-κB Signaling.

DOCK7 ATM

2.41e-041362230254148
Pubmed

IgD class switching is initiated by microbiota and limited to mucosa-associated lymphoid tissue in mice.

DOCK8 ATM

2.41e-041362228137874
Pubmed

BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.

MINK1 DOCK7 SPART BOD1L1 GCN1 ADCY9 DENND4C

2.62e-0470862739231216
Pubmed

Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity.

DOCK8 DOCK7

2.81e-041462212432077
Pubmed

The CRL4DCAF6 E3 ligase ubiquitinates CtBP1/2 to induce apoptotic signalling and promote intervertebral disc degeneration.

DOCK8 ARID1A KLK3 RING1

4.48e-0419962436688959
Pubmed

BioID Performed on Golgi Enriched Fractions Identify C10orf76 as a GBF1 Binding Protein Essential for Golgi Maintenance and Secretion.

PIKFYVE SPART GCN1 DENND4C

6.09e-0421662431519766
Pubmed

P300 Interacted With N-Myc and Regulated Its Protein Stability via Altering Its Post-Translational Modifications in Neuroblastoma.

TRRAP RING1

9.14e-042562236708875
Pubmed

Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

FOCAD RADIL HYDIN

9.38e-0410762311347906
Pubmed

PROTAC-mediated degradation reveals a non-catalytic function of AURORA-A kinase.

FRY DOCK8 DOCK7 OBI1

1.00e-0324762432989298
Pubmed

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.

GLB1 NRDC MINK1 MID1 DOCK7 RHOT1

1.05e-0365062638777146
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

KARS1 DOCK7 ATM ARID1A TRRAP GCN1

1.08e-0365362622586326
Pubmed

Gene knockouts that cause female infertility: search for novel contraceptive targets.

ATM GDF9

1.15e-032862215970507
Pubmed

RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.

KIAA1549 ARID1A GCN1 RNF43

1.26e-0326362434702444
Pubmed

A Single Adaptable Cochaperone-Scaffold Complex Delivers Nascent Iron-Sulfur Clusters to Mammalian Respiratory Chain Complexes I-III.

RCE1 GLB1 TREM1 OBI1 DENND4C RHOT1

1.39e-0368662628380382
Pubmed

Mouse screen reveals multiple new genes underlying mouse and human hearing loss.

NUTM2E NUTM2B TREM1 TRRAP ADCY9 DENND4C RHOT1 WDR47

1.58e-03124262830973865
Cytoband16p13.11

NPIPA1 NPIPA3 NPIPA2

4.07e-062362316p13.11
CytobandEnsembl 112 genes in cytogenetic band chr16p13

NPIPA1 NPIPA3 NPIPA7 NPIPA2 ADCY9

2.82e-04426625chr16p13
Cytoband10q22.3

NUTM2E NUTM2B

1.56e-034362210q22.3
GeneFamilyGuanylate cyclase receptors|DENN/MADD domain containing

DENND5B DENND4C

1.06e-0325352504
GeneFamilyRing finger proteins

MID1 OBI1 RNF43 RING1

1.89e-0327535458
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FRY MID1 DOCK7 SLC38A11 NAALADL2 SLC14A2

2.33e-071896168ff3c3232eff9de4b5c9b22ecb82bc509d773f58
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FRY MID1 DOCK7 SLC38A11 NAALADL2 SLC14A2

2.40e-071906164836ea19308d2a96694f12ab0653b7ce7b101d2f
ToppCell5'-GW_trimst-2-LargeIntestine-Epithelial-mature_enterocytic-Paneth|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FAM117B SLC38A11 KLK3 SLC14A2 RNF43

4.43e-061776153743a7d69db9ac4cad70eb531f7075849f34f16b
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MID1 DOCK7 SLC38A11 NAALADL2 SLC14A2

5.94e-061886154154f4787483c7e076e87a187733a9f666742c3d
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MID1 DOCK7 SLC38A11 NAALADL2 SLC14A2

6.10e-0618961590aae7e806882bebfad78a78e9a16cf56af3ecd4
ToppCelldroplet-Heart-HEART-1m-Hematologic-nan|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTK2B DOCK8 ABHD2 TREM1

2.79e-05127614983489a69d3b1f1fe21110a862ac1dba53e9d31c
Diseasecancer aggressiveness measurement, Gleason score measurement, prostate carcinoma

KLK3 NAALADL2

3.52e-055562EFO_0001663, EFO_0006999, EFO_0007000
DiseaseClear cell sarcoma of kidney

NUTM2E NUTM2B

5.28e-056562C0334488
Disease1-palmitoyl-2-linoleoyl-GPI (16:0/18:2) measurement

DOCK7 TMC4

7.38e-057562EFO_0800609
DiseaseGastric Adenocarcinoma

MINK1 ATM TRRAP

8.68e-0545563C0278701
Diseaselevel of Phosphatidylinositol (16:0_18:2) in blood serum

DOCK7 TMC4

9.83e-058562OBA_2045153
Disease1-palmitoyl-2-oleoyl-GPI (16:0/18:1) measurement

DOCK7 TMC4

1.26e-049562EFO_0800439
Disease1-palmitoyl-2-arachidonoyl-GPI (16:0/20:4) measurement

DOCK7 TMC4

1.26e-049562EFO_0800412
Disease1-stearoyl-2-oleoyl-GPI (18:0/18:1) measurement

DOCK7 TMC4

1.58e-0410562EFO_0800469
Diseasetriglycerides to total lipids in small VLDL percentage

DOCK7 NPIPA1 NPIPA2

1.86e-0458563EFO_0022338
DiseaseIntellectual Disability

SNX14 FRY KARS1 DOCK8 RTTN TRRAP

2.00e-04447566C3714756
Diseaselevel of Phosphatidylinositol (16:0_18:1) in blood serum

DOCK7 TMC4

2.31e-0412562OBA_2045152
Diseasephosphatidylcholine 40:7 measurement

NPIPA1 NPIPA2

2.72e-0413562EFO_0021477
Disease1-stearoyl-2-linoleoyl-GPI (18:0/18:2) measurement

DOCK7 TMC4

2.72e-0413562EFO_0800413
DiseaseAdenocarcinoma Of Esophagus

SPART ARID1A

3.17e-0414562C0279628
Disease1-stearoyl-2-dihomo-linolenoyl-GPI (18:0/20:3n3 or 6) measurement

DOCK7 TMC4

3.17e-0414562EFO_0022085
Disease1-stearoyl-2-arachidonoyl-GPI (18:0/20:4) measurement

DOCK7 TMC4

4.17e-0416562EFO_0800184
DiseaseHMG CoA reductase inhibitor use measurement

DOCK7 FAM117B ARID1A DENND4C

4.62e-04189564EFO_0009932
Diseaselevel of Phosphatidylinositol (18:0_18:1) in blood serum

DOCK7 TMC4

5.31e-0418562OBA_2045155
Diseaseintrahepatic cholangiocarcinoma (is_marker_for)

ARID1A RNF43

5.93e-0419562DOID:4928 (is_marker_for)
Diseasecholesteryl ester measurement, intermediate density lipoprotein measurement

DOCK7 NPIPA1 NPIPA2

7.68e-0494563EFO_0008595, EFO_0010351
DiseaseGranulomatous Slack Skin

ATM ARID1A

7.98e-0422562C0376407
DiseaseAdenocarcinoma of large intestine

ATM TRRAP RNF43

8.16e-0496563C1319315
Diseaselipid measurement, intermediate density lipoprotein measurement

DOCK7 NPIPA1 NPIPA2

8.16e-0496563EFO_0004529, EFO_0008595
Diseasetotal cholesterol measurement, very low density lipoprotein cholesterol measurement

DOCK7 NPIPA1 ARID1A NPIPA2

8.72e-04224564EFO_0004574, EFO_0008317
DiseaseLymphoma, T-Cell, Cutaneous

ATM ARID1A

8.72e-0423562C0079773
Diseasecholesteryl ester measurement, very low density lipoprotein cholesterol measurement

DOCK7 NPIPA1 ARID1A NPIPA2

8.86e-04225564EFO_0008317, EFO_0010351
Diseasephospholipids:total lipids ratio

DOCK7 NPIPA1 ARID1A NPIPA2

9.16e-04227564EFO_0020946
DiseaseIntrahepatic Cholangiocarcinoma

ARID1A RNF43

9.51e-0424562C0345905
DiseaseExtrahepatic Cholangiocarcinoma

ARID1A RNF43

9.51e-0424562C3805278
DiseaseCholangiocarcinoma

ARID1A RNF43

1.12e-0326562C0206698
Diseasecomparative body size at age 10, self-reported

FOCAD PLCD4 SDR16C5 GCN1 ADCY9

1.20e-03420565EFO_0009819
Diseaseimmature platelet fraction

SH2D4A DOCK8 RTTN

1.34e-03114563EFO_0009187
Diseaselongitudinal BMI measurement, response to amisulpride

SLC14A2 ADCY9

1.39e-0329562EFO_0005937, EFO_0010718

Protein segments in the cluster

PeptideGeneStartEntry
VYKIPPTTTKALCPL

TREM1

151

Q9NP99
PPSLETASPLYLLLK

EPB42

466

P16452
LKSCPLLTKEYIPPL

ABHD2

56

P08910
CISYSFLPKPDLPQL

DEFB132

56

Q7Z7B7
TGCPSLLPILEPKYA

SDR16C5

236

Q8N3Y7
LKTPAECLLYPLPPS

NPIPA1

286

Q9UND3
PTLATAKPPYVCDIT

KIAA1549

936

Q9HCM3
KSLYICLPALLECPP

RADIL

576

Q96JH8
LDLSPYPESICLPVL

ARID1A

2071

O14497
LCLPISLIPGLTLYS

ERVFC1-1

376

P60608
EVTKLLSYLCTIPRP

KIAA1755

611

Q5JYT7
CCYKKLLSPPIIPSD

HECTD2

526

Q5U5R9
ILCPSGPIKSLYPLT

GLB1

391

P16278
PLTDPKLYGSLPLCV

RCE1

301

Q9Y256
YLFPLLKIPPDCTTE

RHOT1

286

Q8IXI2
EELYDLPAPCTPLSL

OBI1

381

Q5W0B1
VKPPKYLLDSCAPLL

GCN1

236

Q92616
LKTPAECLLYPLPPS

NPIPA3

286

F8WFD2
KTPAECLLYPLPPSA

NPIPA2

306

E9PIF3
CLLYPLPPSADDNLK

NPIPA2

311

E9PIF3
PPATYSVALLAPKCE

BOD1L1

2586

Q8NFC6
SYSPIRLLEVCVPLP

PIKFYVE

1381

Q9Y2I7
SKYPASLPNCELSPL

ATM

421

Q13315
REVPCKTPYTELLPI

HYDIN

4736

Q4G0P3
YVTLNLPCSLLTPPA

DOCK7

1131

Q96N67
TGSYCLPVALEKLPP

DOCK8

681

Q8NF50
AFCLVSILKPLLPTP

FAM117B

511

Q6P1L5
LYVSKSICLITPLPF

DENND5B

186

Q6ZUT9
CPYIPLCPLSLAAVL

DENND4C

446

Q5VZ89
PLLLLYVSLCPDSSV

ADCY9

931

O60503
RPSCVPAKYSPLSVL

GDF9

416

O60383
LPPLYSVSLALLSCE

FRY

1311

Q5TBA9
KPDLCPPVLYTLMTR

PTK2B

646

Q14289
VPLSCALPKVTLPNY

CLIP3

266

Q96DZ5
PLIFIIPSACYLKLS

SLC38A11

316

Q08AI6
VSRPLELCYAPTKDP

RING1

391

Q06587
GSCYLKLLSLTPPLV

FOCAD

756

Q5VW36
IDTCLIKTYLSRPPT

MINK1

266

Q8N4C8
LSLKTPSECVLYPLP

NPIPA7

261

E9PJI5
KTPAECLLYPLPPSA

NPIPA7

306

E9PJI5
CLLYPLPPSADDNLK

NPIPA7

311

E9PJI5
LSLKTPSECVLYPLP

NPIPA8

261

P0DM63
KTPAECLLYPLPPSA

NPIPA8

306

P0DM63
CLLYPLPPSADDNLK

NPIPA8

311

P0DM63
TPPDPGLLSYIDKLC

NUTM2B

556

A6NNL0
TPPDPGLLSYIDKLC

NUTM2E

556

B1AL46
PLPKLCVFVTPSLLS

RTTN

1601

Q86VV8
KPILCPALSSLVIYL

PLCD4

486

Q9BRC7
LSIIPYEITLLSPCL

KARS1

196

Q15046
YRLSPPVLPLCSLKE

NSUN7

466

Q8NE18
LDKRLLPETPGPCYS

RNF43

706

Q68DV7
LVPLDYTTCPDVKVP

CIB3

41

Q96Q77
ADLLTPLISKLSPYP

WDR47

281

O94967
YPLVPDRSPVLKCTA

SPART

276

Q8N0X7
IALTSLTIKLPYCGP

OR4E1

161

P0C645
LFPYILPPKATDCRS

SNX14

251

Q9Y5W7
LLYSIFLIPPSKLCG

TMC4

606

Q7Z404
KLLECLDYLTAPNPP

MID1

371

O15344
TYLPTSPLLADCIIP

NRDC

1116

O43847
PLVCLLSPTAYPKAL

SCAI

451

Q8N9R8
EPITSLGKELLLYPC

SH2D4A

426

Q9H788
SSPLLPEPLSSRYKL

SLC14A2

6

Q15849
YLVSCLKLLPPALLT

WDR87

631

Q6ZQQ6
TKLPCYKSLPSLVPL

TRRAP

1351

Q9Y4A5
TTKICSLPPIFEILP

XRRA1

341

Q6P2D8
SEPCALPERPSLYTK

KLK3

231

P07288
LLYIDPCDLPKTVNP

NAALADL2

326

Q58DX5