Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioncalcium- and calmodulin-responsive adenylate cyclase activity

ADCY1 ADCY6

9.74e-055632GO:0008294
GeneOntologyMolecularFunctiontelomerase activity

DKC1 TEP1

2.04e-047632GO:0003720
GeneOntologyMolecularFunctionATPase-coupled lipid transmembrane transporter activity

ABCC4 ABCA12

3.48e-049632GO:0034040
GeneOntologyMolecularFunctionABC-type transporter activity

ABCC4 ABCA12 ABCA9

4.97e-0449633GO:0140359
GeneOntologyMolecularFunctionATP-dependent activity

DNAL4 ABCC4 ABCA12 STARD9 DDX25 ABCA9 DHX8 KIF2C

6.67e-04614638GO:0140657
GeneOntologyMolecularFunctionRNA-directed DNA polymerase activity

DKC1 TEP1

8.70e-0414632GO:0003964
GeneOntologyBiologicalProcessRNA localization

SMG1 ATR DDX25 DKC1 THOC2 NUP160 HTT

4.84e-06217647GO:0006403
GeneOntologyBiologicalProcessregulation of cellular response to heat

ATR MTOR DNAJC7

1.55e-0516643GO:1900034
GeneOntologyBiologicalProcessestablishment of RNA localization

SMG1 ATR DDX25 THOC2 NUP160 HTT

1.88e-05178646GO:0051236
GeneOntologyBiologicalProcessmRNA export from nucleus

SMG1 DDX25 THOC2 NUP160

8.24e-0574644GO:0006406
GeneOntologyBiologicalProcessmRNA transport

SMG1 DDX25 THOC2 NUP160 HTT

8.75e-05145645GO:0051028
GeneOntologyBiologicalProcessnucleobase-containing compound transport

SMG1 ABCC4 DDX25 THOC2 NUP160 HTT

1.22e-04249646GO:0015931
GeneOntologyBiologicalProcessmulticellular organismal-level chemical homeostasis

ABCA12 PLA2G4A ADCY6 HTT

1.76e-0490644GO:0140962
GeneOntologyBiologicalProcessRNA transport

SMG1 DDX25 THOC2 NUP160 HTT

2.11e-04175645GO:0050658
GeneOntologyBiologicalProcessnucleic acid transport

SMG1 DDX25 THOC2 NUP160 HTT

2.11e-04175645GO:0050657
GeneOntologyBiologicalProcessregulation of protein localization to nucleus

LIMK2 MTOR DKC1 PARP9 HTT

2.17e-04176645GO:1900180
GeneOntologyBiologicalProcessRNA export from nucleus

SMG1 DDX25 THOC2 NUP160

2.26e-0496644GO:0006405
GeneOntologyCellularComponentintracellular protein-containing complex

PRAMEF7 KCTD5 MTOR WWP1 RNF144A DNAJC9 ELP1 PSMD4 TADA2A SYVN1 PRAMEF8

1.61e-049726411GO:0140535
DomainARM-like

SMG1 ATR ARMC3 MTOR UNC45B DOCK10 HUWE1 NIPBL TARBP1 HTT

1.35e-082706010IPR011989
DomainFATC

SMG1 ATR MTOR

3.14e-075603PF02260
DomainFAT

SMG1 ATR MTOR

6.26e-076603PS51189
DomainFATC

SMG1 ATR MTOR

6.26e-076603PS51190
DomainFATC_dom

SMG1 ATR MTOR

6.26e-076603IPR003152
DomainPIK_FAT

SMG1 ATR MTOR

6.26e-076603IPR014009
DomainFATC

SMG1 ATR MTOR

6.26e-076603SM01343
DomainARM-type_fold

SMG1 ATR ARMC3 MTOR UNC45B HUWE1 NIPBL TARBP1 HTT

1.26e-06339609IPR016024
DomainHEAT_REPEAT

SMG1 ATR MTOR NIPBL HTT

2.98e-0670605PS50077
DomainPI3/4_kinase_CS

SMG1 ATR MTOR

1.40e-0515603IPR018936
Domain-

SMG1 ATR MTOR

1.71e-05166031.10.1070.11
DomainPI3Kc

SMG1 ATR MTOR

1.71e-0516603SM00146
DomainPI3/4_kinase_cat_dom

SMG1 ATR MTOR

2.49e-0518603IPR000403
DomainPI3_PI4_kinase

SMG1 ATR MTOR

2.49e-0518603PF00454
DomainPI3_4_KINASE_3

SMG1 ATR MTOR

2.49e-0518603PS50290
DomainPI3_4_KINASE_1

SMG1 ATR MTOR

2.49e-0518603PS00915
DomainPI3_4_KINASE_2

SMG1 ATR MTOR

2.49e-0518603PS00916
DomainHEAT

ATR MTOR NIPBL HTT

3.59e-0558604IPR000357
Domain-

ATR ARMC3 MTOR UNC45B NIPBL HTT

7.73e-052226061.25.10.10
DomainFAT

ATR MTOR

1.51e-046602PF02259
DomainPIK-rel_kinase_FAT

ATR MTOR

1.51e-046602IPR003151
DomainAC_N

ADCY1 ADCY6

2.81e-048602IPR032628
DomainAdcy

ADCY1 ADCY6

2.81e-048602IPR030672
DomainAC_N

ADCY1 ADCY6

2.81e-048602PF16214
DomainABC_tran

ABCC4 ABCA12 ABCA9

4.92e-0448603PF00005
DomainABC_TRANSPORTER_2

ABCC4 ABCA12 ABCA9

4.92e-0448603PS50893
DomainABC_TRANSPORTER_1

ABCC4 ABCA12 ABCA9

5.23e-0449603PS00211
Domain-

CFAP54 ATR MTOR UNC45B DNAJC7

5.31e-042076051.25.40.10
DomainElongated_TPR_rpt_dom

UNC45B DNAJC7

5.48e-0411602IPR023114
DomainABC_transporter-like

ABCC4 ABCA12 ABCA9

5.55e-0450603IPR003439
DomainABC_A

ABCA12 ABCA9

6.56e-0412602IPR026082
DomainTPR-like_helical_dom

CFAP54 ATR MTOR UNC45B DNAJC7

9.05e-04233605IPR011990
DomainA/G_cyclase_CS

ADCY1 ADCY6

1.34e-0317602IPR018297
DomainP-loop_NTPase

ABCC4 ABCA12 STARD9 DDX25 EIF5B TEP1 ABCA9 DHX8 KIF2C

1.45e-03848609IPR027417
DomainNucleotide_cyclase

ADCY1 ADCY6

1.50e-0318602IPR029787
Domain-

ADCY1 ADCY6

1.50e-03186023.30.70.1230
DomainGUANYLATE_CYCLASE_1

ADCY1 ADCY6

1.68e-0319602PS00452
DomainGuanylate_cyc

ADCY1 ADCY6

1.68e-0319602PF00211
DomainGUANYLATE_CYCLASE_2

ADCY1 ADCY6

1.68e-0319602PS50125
DomainPRAME_family

PRAMEF7 PRAMEF8

1.68e-0319602IPR026271
DomainA/G_cyclase

ADCY1 ADCY6

1.68e-0319602IPR001054
DomainCYCc

ADCY1 ADCY6

1.68e-0319602SM00044
DomainUIM

PSMD4 HUWE1

2.68e-0324602PS50330
DomainUIM_dom

PSMD4 HUWE1

2.90e-0325602IPR003903
DomainSANT_dom

TADA2A CRAMP1

3.14e-0326602IPR017884
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

STXBP3 ATR MTOR STARD9 DNAJC9 EIF5B ELP1 DKC1 PSMD4 HUWE1 DNAJC7 THOC2 NIPBL NUP160 DHX8

3.45e-081425641530948266
Pubmed

A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability.

SMG1 ATR MTOR

3.31e-07864320810650
Pubmed

Tel2 regulates the stability of PI3K-related protein kinases.

SMG1 ATR MTOR

7.07e-071064318160036
Pubmed

Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly.

SMG1 ATR MTOR

9.70e-071164320427287
Pubmed

Mutant HTT (huntingtin) impairs mitophagy in a cellular model of Huntington disease.

MTOR SYVN1 HTT

9.70e-071164332093570
Pubmed

Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.

SMG1 CCSER2 HECTD4 DNAJC9 ELP1 DKC1 HUWE1 NUP160

1.47e-0644064834244565
Pubmed

The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.

MTOR EIF5B ELP1 DKC1 PSMD4 HUWE1 DNAJC7 THOC2 NUP160

2.49e-0663864933239621
Pubmed

CK2 phospho-dependent binding of R2TP complex to TEL2 is essential for mTOR and SMG1 stability.

SMG1 ATR MTOR

2.66e-061564320864032
Pubmed

Epidermal growth factor induces platelet-activating factor production through receptors transactivation and cytosolic phospholipase A2 in ovarian cancer cells.

EGF PLA2G4A

3.33e-06264224721622
Pubmed

Blockage of cytosolic phospholipase A2 alpha sensitizes aggressive breast cancer to doxorubicin through suppressing ERK and mTOR kinases.

MTOR PLA2G4A

3.33e-06264229307829
Pubmed

Ubiquitin ligase Hrd1 enhances the degradation and suppresses the toxicity of polyglutamine-expanded huntingtin.

SYVN1 HTT

3.33e-06264217141218
Pubmed

A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways.

LIMK2 UNC45B DNAJC9 PSMD4 DNAJC7 TARBP1 DHX8

4.75e-0636364725036637
Pubmed

KAP1 facilitates reinstatement of heterochromatin after DNA replication.

MTOR DNAJC9 ELP1 PSMD4 SMS HUWE1 NIPBL NUP160 DHX8

5.53e-0670464929955894
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

LIMK2 VPS52 ABCA12 WWP1 PCDH19 TADA2A TEP1 PCCA ADCY6 LGALS3BP KNL1

5.54e-061116641131753913
Pubmed

Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.

MTOR DNAJC9 EIF5B PSMD4 PARP9 HUWE1 DNAJC7 PCCA NUP160 LGALS3BP KNL1 KIF2C

6.41e-061367641232687490
Pubmed

Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database.

ABCC4 ABCA12 ABCA9

8.93e-06226438894702
Pubmed

MicroRNA-18a promotes cancer progression through SMG1 suppression and mTOR pathway activation in nasopharyngeal carcinoma.

SMG1 MTOR

9.99e-06364231659158
Pubmed

Epidermal growth factor induces p11 gene and protein expression and down-regulates calcium ionophore-induced arachidonic acid release in human epithelial cells.

EGF PLA2G4A

9.99e-06364212163506
Pubmed

The ATM-related kinase, hSMG-1, bridges genome and RNA surveillance pathways.

SMG1 ATR

9.99e-06364215279777
Pubmed

Identifying biological pathways that underlie primordial short stature using network analysis.

EIF5B ELP1 DKC1 HUWE1 DNAJC7 THOC2 NIPBL NUP160 LGALS3BP DHX8

1.68e-051024641024711643
Pubmed

5-HT(6) receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia.

SMG1 ATR MTOR

1.68e-052764323027611
Pubmed

Cul3-KLHL20 E3 ubiquitin ligase plays a key role in the arms race between HIV-1 Nef and host SERINC5 restriction.

WWP1 HUWE1 SYVN1

1.88e-052864335474067
Pubmed

HUWE1 and TRIP12 collaborate in degradation of ubiquitin-fusion proteins and misframed ubiquitin.

PSMD4 HUWE1

2.00e-05464223209776
Pubmed

RNF144A sustains EGFR signaling to promote EGF-dependent cell proliferation.

EGF RNF144A

2.00e-05464230171075
Pubmed

Quantitative nuclear proteomics identifies mTOR regulation of DNA damage response.

ATR MTOR

2.00e-05464219955088
Pubmed

ADAD1 and ADAD2, testis-specific adenosine deaminase domain-containing proteins, are required for male fertility.

SMG1 DDX25

2.00e-05464232665638
Pubmed

Huntingtin promotes mTORC1 signaling in the pathogenesis of Huntington's disease.

MTOR HTT

2.00e-05464225351248
Pubmed

An evaluation of the assembly of an approximately 15-Mb region on human chromosome 13q32-q33 linked to bipolar disorder and schizophrenia.

ABCC4 MBNL2 PCCA

2.10e-052964311991713
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

MTOR EIF5B ELP1 HUWE1 THOC2 NIPBL NUP160 DHX8

2.60e-0565364822586326
Pubmed

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.

VPS52 KCTD5 DNAJC9 DKC1 PSMD4 SMS TADA2A SYVN1 NIPBL CRAMP1 HTT

2.78e-051327641132694731
Pubmed

Differential regulation of telomerase activity by six telomerase subunits.

DKC1 TEP1

3.32e-05564212135483
Pubmed

Mammalian adenylyl cyclase family members are randomly located on different chromosomes.

ADCY1 ADCY6

3.32e-0556427959689
Pubmed

Epidermal growth factor and hypoxia-induced expression of CXC chemokine receptor 4 on non-small cell lung cancer cells is regulated by the phosphatidylinositol 3-kinase/PTEN/AKT/mammalian target of rapamycin signaling pathway and activation of hypoxia inducible factor-1alpha.

EGF MTOR

3.32e-05564215802268
Pubmed

Disease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation.

HUWE1 DNAJC7 LGALS3BP

4.06e-053664335379950
Pubmed

Direct interaction between the PRDM3 and PRDM16 tumor suppressors and the NuRD chromatin remodeling complex.

DNAJC9 DKC1 THOC2 NUP160 LGALS3BP

4.88e-0521564530462309
Pubmed

Mapping of adenylyl cyclase genes type I, II, III, IV, V, and VI in mouse.

ADCY1 ADCY6

4.98e-0566427766992
Pubmed

Ubiquitination-mediated degradation of SIRT1 by SMURF2 suppresses CRC cell proliferation and tumorigenesis.

WWP1 SYVN1

4.98e-05664232361710
Pubmed

Expression and regulation of adenylyl cyclase isoforms in the human adrenal gland.

ADCY1 ADCY6

4.98e-05664211549699
Pubmed

Differential Alteration in Expression of Striatal GABAAR Subunits in Mouse Models of Huntington's Disease.

GABRB3 HTT

6.96e-05764228676743
Pubmed

Differential expression of adenylyl cyclase mRNAs in lacrimal glands of NZB/NZW and NOD pre-autoimmune mice.

ADCY1 ADCY6

6.96e-05764212613887
Pubmed

A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.

PTPN3 MTOR ELP1 PSMD4 SMS HUWE1 PTPRU NUP160 KIF2C

7.07e-0597464928675297
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

ABCC4 MBNL2 WWP1 RNF144A HECTD4 HUWE1 TEP1 PCCA ADCY1 CRAMP1 HTT

7.86e-051489641128611215
Pubmed

MYC multimers shield stalled replication forks from RNA polymerase.

DNAJC9 DKC1 PSMD4 HUWE1 DNAJC7 THOC2 PCCA KNL1 KIF2C

7.94e-0598964936424410
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

ATR EIF5B DKC1 PLA2G4A HUWE1 THOC2 NIPBL ADCY6

8.56e-0577464815302935
Pubmed

Cloning, characterization, and genomic structure of the mouse Ikbkap gene.

PTPN3 ELP1

9.27e-05864211747609
Pubmed

Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.

ATR ELP1 HUWE1 NIPBL KNL1 DHX8 KIF2C

9.65e-0558264720467437
Pubmed

SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors.

HECTD4 EIF5B DKC1 NUP160 DHX8

9.95e-0525064533536335
Pubmed

The human RNA surveillance factor UPF1 is required for S phase progression and genome stability.

SMG1 ATR

1.19e-04964216488880
Pubmed

Ubiquitin Linkage-Specific Affimers Reveal Insights into K6-Linked Ubiquitin Signaling.

RNF144A HUWE1

1.19e-04964228943312
Pubmed

Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaS.

ADCY1 ADCY6

1.19e-0496429417641
Pubmed

Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms.

ADCY1 ADCY6

1.19e-04964212503609
Pubmed

SNPs in genes coding for ROS metabolism and signalling in association with docetaxel clearance.

DPYD EGF

1.19e-04964220157331
Pubmed

Role of the calcium modulated cyclases in the development of the retinal projections.

ADCY1 ADCY6

1.19e-04964217229090
Pubmed

Proteomic analysis of the NOS2 interactome in human airway epithelial cells.

PSMD4 HUWE1 DNAJC7 LGALS3BP

1.25e-0413864423438482
Pubmed

The human ATP-binding cassette (ABC) transporter superfamily.

ABCA12 ABCA9

1.49e-041064211435397
Pubmed

Purification and characterization of a soluble form of mammalian adenylyl cyclase.

ADCY1 ADCY6

1.49e-04106428663304
Pubmed

Comprehensive analysis of the expression patterns of the adenylate cyclase gene family in the developing and adult mouse brain.

ADCY1 ADCY6

1.49e-041064216615126
Pubmed

A proteomic analysis of ataxia telangiectasia-mutated (ATM)/ATM-Rad3-related (ATR) substrates identifies the ubiquitin-proteasome system as a regulator for DNA damage checkpoints.

ATR HUWE1

1.49e-041064217478428
Pubmed

Mechanism of human immunodeficiency virus-induced complement expression in astrocytes and neurons.

ADCY1 ADCY6

1.49e-041064211884542
Pubmed

Formation of neurodegenerative aggresome and death-inducing signaling complex in maternal diabetes-induced neural tube defects.

MTOR HTT

1.49e-041064228396396
Pubmed

Regulation of error-prone translesion synthesis by Spartan/C1orf124.

PSMD4 HUWE1 DNAJC7

1.79e-045964323254330
Pubmed

Human immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures.

ADCY1 ADCY6

1.81e-041164211299302
Pubmed

A high-coverage shRNA screen identifies TMEM129 as an E3 ligase involved in ER-associated protein degradation.

PSMD4 SYVN1

1.81e-041164224807418
Pubmed

Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 envelope protein of human immunodeficiency virus type 1.

ADCY1 ADCY6

1.81e-041164210089566
Pubmed

gp120- and TNF-alpha-induced modulation of human B cell function: proliferation, cyclic AMP generation, Ig production, and B-cell receptor expression.

ADCY1 ADCY6

1.81e-041164210808179
Pubmed

Rheb binds and regulates the mTOR kinase.

ATR MTOR

2.17e-041264215854902
Pubmed

HIV-1 envelope protein gp41 modulates expression of interleukin-10 and chemokine receptors on monocytes, astrocytes and neurones.

ADCY1 ADCY6

2.17e-041264210807185
Pubmed

Charting the landscape of tandem BRCT domain-mediated protein interactions.

MTOR EIF5B DKC1 PSMD4 TADA2A DNAJC7 KIF2C

2.29e-0467064722990118
Pubmed

K63 ubiquitylation triggers proteasomal degradation by seeding branched ubiquitin chains.

WWP1 PSMD4 HUWE1

2.39e-046564329378950
Pubmed

Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.

DNAJC9 EIF5B ELP1 DKC1 HUWE1 DNAJC7 NIPBL TARBP1 LGALS3BP DHX8

2.46e-041415641028515276
Pubmed

Poly(ADP-ribosyl)ation of BRD7 by PARP1 confers resistance to DNA-damaging chemotherapeutic agents.

DNAJC9 EIF5B DKC1 HUWE1 DNAJC7 THOC2

2.73e-0448664630940648
Pubmed

A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.

SMG1 MTOR EIF5B ELP1 DKC1 PSMD4 HUWE1 DNAJC7 THOC2 LGALS3BP

2.83e-041440641030833792
Pubmed

Isoforms of mammalian adenylyl cyclase: multiplicities of signaling.

ADCY1 ADCY6

2.99e-041464214993377
Pubmed

Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development.

DNAJC9 EIF5B DKC1 PSMD4 HUWE1 LGALS3BP

3.04e-0449664631343991
Pubmed

A high-throughput approach for measuring temporal changes in the interactome.

MTOR EIF5B ELP1 PLA2G4A PSMD4 SMS HUWE1 DNAJC7 NUP160 HTT

3.08e-041455641022863883
Pubmed

The deubiquitinase USP9X regulates FBW7 stability and suppresses colorectal cancer.

MTOR EIF5B HUWE1

3.11e-047164329346117
Pubmed

A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

EIF5B DKC1 PLA2G4A HUWE1 THOC2 NIPBL

3.28e-0450364616964243
Pubmed

Mechanism of GTP hydrolysis by G-protein alpha subunits.

ADCY1 ADCY6

3.45e-04156427937899
Pubmed

cAMP-dependent protein kinase: framework for a diverse family of regulatory enzymes.

ADCY1 ADCY6

3.45e-04156422165385
Pubmed

Huntingtin functions as a scaffold for selective macroautophagy.

MTOR HTT

3.45e-041564225686248
Pubmed

A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins.

SMG1 PTPN3 ABCC4 STXBP3 WWP1 TARBP1 NUP160

3.50e-0471964735337019
Pubmed

Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.

TBX15 GABRB3 EGF ATR NIPBL

3.65e-0433164520634891
Pubmed

Proteome-wide analysis of USP14 substrates revealed its role in hepatosteatosis via stabilization of FASN.

DNAJC9 EIF5B PSMD4 DNAJC7 NUP160

3.80e-0433464530425250
Pubmed

A High-Density Human Mitochondrial Proximity Interaction Network.

VPS52 DNAJC9 ELP1 DKC1 PSMD4 HUWE1 DNAJC7 NUP160 LGALS3BP KIF2C

3.83e-041496641032877691
Pubmed

Combinatorial CRISPR screen identifies fitness effects of gene paralogues.

SMG1 LIMK2 ATR HTT

3.92e-0418664433637726
Pubmed

Assembly and structure of Lys33-linked polyubiquitin reveals distinct conformations.

WWP1 HUWE1

3.93e-041664225723849
Pubmed

Molecular characterization of the ankle-link complex in cochlear hair cells and its role in the hair bundle functioning.

ADCY1 ADCY6

3.93e-041664217567809
Pubmed

Primary Autosomal Recessive Microcephalies and Seckel Syndrome Spectrum Disorders – RETIRED CHAPTER, FOR HISTORICAL REFERENCE ONLY

ATR KNL1

3.93e-041664220301772
Pubmed

PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry.

ATR DNAJC9 PARP9 THOC2 NIPBL

4.12e-0434064524332808
Pubmed

Comprehensive proteomic analysis of interphase and mitotic 14-3-3-binding proteins.

PTPN3 MTOR WWP1 HECTD4

4.24e-0419064415161933
Pubmed

Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.

DNAJC9 EIF5B DKC1 THOC2 NIPBL KIF2C

4.45e-0453364630554943
Pubmed

Global mapping of herpesvirus-host protein complexes reveals a transcription strategy for late genes.

VPS52 KCTD5 WWP1 SYVN1 DNAJC7 KNL1

4.45e-0453364625544563
Pubmed

Differential expression of PRAMEL1, a cancer/testis antigen, during spermatogenesis in the mouse.

PRAMEF7 PRAMEF8

4.45e-041764223565261
Pubmed

Mouse Pramel1 regulates spermatogonial development by inhibiting retinoic acid signaling during spermatogenesis.

PRAMEF7 PRAMEF8

4.45e-041764237781892
Pubmed

C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.

STXBP3 ELP1 DKC1 PSMD4 HUWE1 DNAJC7 THOC2 NUP160 LGALS3BP

4.71e-04125764937317656
Pubmed

The promoter of the oocyte-specific gene, Oog1, functions in both male and female meiotic germ cells in transgenic mice.

PRAMEF7 PRAMEF8

5.00e-041864223894331
Pubmed

Identification of FMRP target mRNAs in the developmental brain: FMRP might coordinate Ras/MAPK, Wnt/β-catenin, and mTOR signaling during corticogenesis.

MTOR NIPBL

5.00e-041864233323119
Pubmed

A systematic study of nuclear interactome of C-terminal domain small phosphatase-like 2 using inducible expression system and shotgun proteomics.

NIPBL NUP160

5.00e-041864226674342
Pubmed

Oogenesin is a novel mouse protein expressed in oocytes and early cleavage-stage embryos.

PRAMEF7 PRAMEF8

5.00e-041864212890732
Pubmed

Oocyte-specific gene Oog1 suppresses the expression of spermatogenesis-specific genes in oocytes.

PRAMEF7 PRAMEF8

5.00e-041864229731491
InteractionHSP90AA1 interactions

SMG1 LIMK2 ATR MTOR UNC45B WWP1 EIF5B PLA2G4A PSMD4 TADA2A HUWE1 SYVN1 DNAJC7 THOC2 NIPBL LGALS3BP HTT

1.59e-0712636217int:HSP90AA1
InteractionTELO2 interactions

SMG1 ATR MTOR HUWE1 PTPRU DNAJC7

3.65e-06135626int:TELO2
Cytoband13q32

ABCC4 PCCA

1.48e-041364213q32
Cytoband9q31

PTPN3 ELP1

2.57e-04176429q31
CytobandEnsembl 112 genes in cytogenetic band chr13q32

ABCC4 MBNL2 PCCA

3.37e-0496643chr13q32
GeneFamilyAdenylate cyclases|Deafness associated genes

ADCY1 ADCY6

2.94e-041047253
GeneFamilyATP binding cassette subfamily A

ABCA12 ABCA9

5.90e-0414472805
GeneFamilyPRAME family

PRAMEF7 PRAMEF8

1.76e-0324472686
CoexpressionHAMAI_APOPTOSIS_VIA_TRAIL_UP

STXBP3 ATR WWP1 DOCK10 EIF5B SMS DNAJC7 PCCA NIPBL ZNF443 KNL1

4.19e-076566311M18979
ToppCellTransverse-Macrophage-LYVE1_Macrophage|Macrophage / Region, Cell class and subclass

CFAP54 MTOR PLA2G4A ABCA9 ZNF443 CRAMP1

4.20e-07199646fd75dccb37d96448edf72b7d042b06833d4ead24
ToppCelldroplet-Marrow-nan-3m-Myeloid-nan|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SMG1 DOCK10 TEP1 NIPBL ABCA9

6.44e-06182645f8c73baaaca145e2efc48f10f636feb79c8fc779
ToppCell(09)_Interm._secr.>cil.-(2)_GFP_FOXI1|(09)_Interm._secr.>cil. / shred by cell type by condition

WWP1 EIF5B PARP9 THOC2 NIPBL

9.93e-06199645fc680f85ebd3bab4c72876a19a461b0afb5f51ce
ToppCellPND10-Immune-Immune_Myeloid-DC-cDC2-cDC2_G2M|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DOCK10 SYVN1 KNL1 KIF2C

1.00e-041686444c402a1613fcf0a6e4d9b9d5551812940e91ff32
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ABCC4 LOXHD1 DOCK10 ADCY1

1.20e-0417664425ebc8716aa44e44fce577701e3e82c6745a75ab
ToppCell368C-Myeloid-Dendritic-cDC_proliferating_1|368C / Donor, Lineage, Cell class and subclass (all cells)

WWP1 DNAJC9 TARBP1 KNL1

1.28e-04179644ec69e1dd897414033ba5b007aa82655a79adca6c
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_ILC-NK_cell-NK_c03-MKI67|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

TBX15 ABCA12 KNL1 KIF2C

1.31e-041806441c1b25f1d22518db5469707131510daae84716a3
ToppCell3'-Distal_airway-Immune_Lymphocytic-Lymphocytic_T/NK-T_cell-T_cells_proliferating-T_cells_proliferating_L.1.1.3.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

HENMT1 DNAJC9 KNL1 KIF2C

1.42e-04184644eaef1dcde60ba14e2c7fd699d01c225487256d82
ToppCell3'-Distal_airway-Immune_Lymphocytic-Lymphocytic_T/NK-T_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

HENMT1 DNAJC9 KNL1 KIF2C

1.42e-04184644fa73738350654066d7f9ebf78359e20ee6cbdd98
ToppCell3'-Distal_airway-Immune_Lymphocytic-Lymphocytic_T/NK-T_cell-T_cells_proliferating|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

HENMT1 DNAJC9 KNL1 KIF2C

1.42e-04184644bba0138c8f7e3645a688b9a4d12f6f2134ee2c08
ToppCelldroplet-Marrow-nan-3m-Myeloid|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SMG1 DOCK10 NIPBL ABCA9

1.45e-041856447adfa929930cfa795cbfbd9f1a0b439e08aa765d
ToppCell10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8|GI_small-bowel / Manually curated celltypes from each tissue

SMG1 DOCK10 HUWE1 NIPBL

1.54e-04188644ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GABRB3 PTPN3 DPYD MBNL2

1.54e-0418864450c1b1d690f0e9443082f2adf4f1b8e9ce4cd337
ToppCellCOVID-19-kidney-DCT|kidney / Disease (COVID-19 only), tissue and cell type

PTPN3 EGF PCCA ABCA9

1.54e-04188644df1fd0819d301679f3c9ea404e942e39095912eb
ToppCell10x_3'_v3-bone_marrow_(10x_3'_v3)-hematologic-hematopoietic_progenitor-common_myeloid_progenitor|bone_marrow_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

ABCC4 DNAJC9 DKC1 ADCY6

1.57e-0418964456156325cc36b1329bf483f81bb74f371ef15e20
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

LOXHD1 RNF144A PLA2G4A ABCA9

1.61e-041906441f83f7f24288a3b9ab33c2e113e845dba96adc8a
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

LOXHD1 RNF144A PLA2G4A ABCA9

1.61e-041906442306aa9dbeaef3be8484a5b236605de23cd75d4c
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

GABRB3 RNF144A PLA2G4A ABCA9

1.61e-04190644445952b70abffadb6ccc1ed4bbf61a88b06b73b3
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

GABRB3 RNF144A PLA2G4A ABCA9

1.61e-041906442e592323085ba9c019d678ac2a784462ab470ed9
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

LOXHD1 RNF144A PLA2G4A ABCA9

1.64e-04191644a58c75e9580139fb370b498d95660f10f3a2a27b
ToppCell368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0.5|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

HENMT1 STARD9 TADA2A HTT

1.64e-04191644cadb7a9de16f4bb21606de0e25cddd2d748c7f0b
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

LOXHD1 RNF144A PLA2G4A ABCA9

1.67e-041926449093a9e94a25682d109a7f6edc256a25a61103a0
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

LOXHD1 RNF144A PLA2G4A ABCA9

1.67e-041926449ed5d49621ec1aa01716dc369bba1450b5f015f5
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

LOXHD1 RNF144A PLA2G4A ABCA9

1.71e-04193644f1199518c3626fd29bfce65070dd21a660671213
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LOXHD1 RNF144A PLA2G4A ABCA9

1.77e-04195644783bfa8110161cbd6def50ce849cae676c39c458
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LOXHD1 RNF144A PLA2G4A ABCA9

1.77e-04195644cad6563cc51d212554152c727fc2c249c6a07e4d
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LOXHD1 RNF144A PLA2G4A ABCA9

1.77e-0419564444d7bef5f59c2c2bad1392ee6aabdaa5d7f531d9
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

LOXHD1 RNF144A PLA2G4A ABCA9

1.81e-04196644a12dd986df65c36f248cf10815c3b8b6238613b0
ToppCellILEUM-non-inflamed-(1)_Highly_activated_T_cells|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

DNAJC9 SMS KNL1 KIF2C

1.81e-041966446a415a2574bd84bd825a2bd6c8e3632a433ff7cf
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LOXHD1 RNF144A PLA2G4A ABCA9

1.81e-04196644ba869f7a86f37fd6d84d6ad69baca0e0faaf5887
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LOXHD1 RNF144A PLA2G4A ABCA9

1.81e-0419664430ad56d49000e4ddce73b4443b3994564bd1e2d6
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

LOXHD1 RNF144A PLA2G4A ABCA9

1.81e-041966443e6803587d8566fd08cb8b290be3b6461743d79c
ToppCellCV-Moderate-6|CV / Virus stimulation, Condition and Cluster

SMG1 DOCK10 EIF5B HUWE1

1.81e-041966447bced0cc2112697593c478fa291b8ed3941fb811
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

LOXHD1 RNF144A PLA2G4A ABCA9

1.84e-04197644b349f8e96d61a4c296af64711e11fc44459a9413
ToppCellLPS_only-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS_only / Treatment groups by lineage, cell group, cell type

PTPN3 ABCC4 PLA2G4A PTPRU

1.84e-041976441a1bee8da6e04b65935c40373eaee4d6c046d9a1
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

LOXHD1 RNF144A PLA2G4A ABCA9

1.84e-041976446d027119a5f7ca2aac1b10837e43f9a2bb54db85
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

LOXHD1 RNF144A PLA2G4A ABCA9

1.84e-04197644c2e390653d5dee7e731c1840cfdab41987dede9b
ToppCellHealthy_donor-T/NK_proliferative|World / disease group, cell group and cell class (v2)

PTPN3 DNAJC9 KNL1 KIF2C

1.92e-041996441311dfd74b991f48b047a439f04f9bf7dfaa0e7a
ToppCellTracheal-NucSeq-Stromal-Peri/Epineurial_-NAF_epineurial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

TBX15 RNF144A PCDH19 ABCA9

1.92e-041996449c2db0bb94cba71a3cc1827844da090e213e0258
ToppCell(03)_KRT6B+-(2)_GFP_FOXI1|(03)_KRT6B+ / shred by cell type by condition

WWP1 EIF5B PARP9 NIPBL

1.92e-04199644c425e7975f492ed5cfcca022248adb627e1d27d4
ToppCell(04)_Interm._basal>secr.-(2)_GFP_FOXI1|(04)_Interm._basal>secr. / shred by cell type by condition

WWP1 EIF5B PARP9 NIPBL

1.92e-0419964453ca3861f9e00dab3f3fbefb0837857ee39ab084
ToppCellTracheal-NucSeq-Stromal-Peri/Epineurial_|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

TBX15 STARD9 RNF144A ABCA9

1.92e-041996443835452e4848d7f7dd8651c17b746b271ef39688
Diseasegallbladder cancer (is_marker_for)

DPYD EGF

8.77e-057612DOID:3121 (is_marker_for)
DiseaseCraniofacial Abnormalities

TBX15 GABRB3 UNC45B NIPBL

3.10e-04156614C0376634
DiseaseDermatitis

EGF PLA2G4A

4.95e-0416612C0011603
Diseasepolycystic kidney disease (biomarker_via_orthology)

MTOR PLA2G4A

7.03e-0419612DOID:0080322 (biomarker_via_orthology)
DiseaseInfiltrating duct carcinoma of female breast

SMG1 ATR

8.61e-0421612C3165106
Diseasehip bone mineral density, fat body mass

MC5R TADA2A

9.46e-0422612EFO_0005409, EFO_0007702
DiseaseLarge cell carcinoma of lung

ATR MTOR

2.00e-0332612C0345958

Protein segments in the cluster

PeptideGeneStartEntry
MEDMIIQCCSEIASL

CFAP54

3031

Q96N23
CCVEMGVDMIEAISL

ADCY6

446

O43306
MAEAEAVCDRVAIMV

ABCA9

1481

Q8IUA7
ANAVCDTMAVTAMIQ

ABCA12

1586

Q86UK0
VEQVVAMIDEEMCIN

DPYD

941

Q12882
VIANCLEDMDTMVQI

ARMC3

256

Q5W041
VVEQMGKFCVDVQVM

DDX25

186

Q9UHL0
VLVTMETAMCLTERN

PTPN3

851

P26045
ADLIEVVMNIEDMLC

PARP9

591

Q8IXQ6
ISLEVMSSSMEICVI

PCDH19

101

Q8TAB3
SNVTMSVDAECVPMV

LGALS3BP

191

Q08380
VMVMKELIRCDEETQ

LIMK2

356

P53671
TLVCEMCAVIDEEEM

LOXHD1

1661

Q8IVV2
MRVETMELCVTACEK

DNAL4

31

O96015
MNESVDVMDVIAICC

NIPBL

2701

Q6KC79
DMDITQSCMVEIDNE

KNL1

1111

Q8NG31
VCVGMNIDIASIDMV

GABRB3

61

P28472
IDLVCDAMRAVMESI

ELP1

816

O95163
VAEGQEICVIEAMKM

PCCA

681

P05165
EVIQPDVMEEMVVSC

HECTD4

896

Q9Y4D8
TEDMVTVLIRACVSM

HUWE1

1751

Q7Z6Z7
LQENEIECMVAAEIM

RNF144A

76

P50876
IVLDVMLDMAECEGV

PTPRU

1096

Q92729
CVRQSAEVENMMISV

ABCC4

996

O15439
DEMTLRHMVQDCTAV

CCSER2

661

Q9H7U1
CVEMGLDMIDTITSV

ADCY1

371

Q08828
KMESMEIIEEIQCQT

ATR

401

Q13535
ITAACEMVAEMVESL

HTT

2356

P42858
CANEEMMRSVIADSI

HENMT1

356

Q5T8I9
SELNQLCTMEEVDMI

DOCK10

2041

Q96BY6
HMLVAEIMVSDQDDC

EGF

821

P01133
ADVAEVVDSQLVCMM

CRAMP1

1211

Q96RY5
VVDSQLVCMMNENSI

CRAMP1

1216

Q96RY5
MDQIMESVLCVQYTE

DNAJC9

141

Q8WXX5
TMIDTSDNTVTVCMD

MBNL2

206

Q5VZF2
NVFDSMICISVVASM

MC5R

116

P33032
MAAAAECDVVMAATE

DNAJC7

1

Q99615
LQCQEEELTQMVSTM

KCTD5

161

Q9NXV2
EQTDMEAVEALVCMS

KLF11

41

O14901
EAICMAIALMTTAVI

DKC1

341

O60832
QASLEMVVMTDCLLS

PRAMEF8

291

Q5VWM4
MVLESTMVCVDNSEY

PSMD4

1

P55036
GEQLIQMETEEMEAC

KIF2C

596

Q99661
CSEEMLTIVSMLSVQ

DHX8

1001

Q14562
QVTEMVLEMSLEVCS

PLA2G4A

126

P47712
EVIMNTGVCVLMASV

OR14A2

131

Q96R54
MQVDATVFTCISMLA

MTOR

476

P42345
AMDNVCIICREEMVT

SYVN1

286

Q86TM6
VTMVEIDQMVIDGCK

SMS

216

P52788
TAQEEMALLEAVMDC

TADA2A

76

O75478
SMELCAAVEVMEQGV

EIF5B

466

O60841
AMSSMEEIQVELQCA

TBX15

106

Q96SF7
VTIMMVVEALCELHC

SMG1

1071

Q96Q15
VVDTSMADVMAACSD

STARD9

4491

Q9P2P6
DAIMETMADQIVTVC

STXBP3

171

O00186
MITIDVENVMEDICS

NUP160

646

Q12769
QASLEMVVMTDCLLS

PRAMEF7

291

Q5VXH5
ITACDAVLERMEQML

VPS52

116

Q8N1B4
ICSLMAVENEEMSLA

UNC45B

226

Q8IWX7
MNLTEDCMVFEDVAI

ZNF749

1

O43361
TSCEMVMAPVHEAVV

THOC2

851

Q8NI27
MMITRAEQVDVVLCG

TEP1

711

Q99973
DVMQETIRNLDCVVM

ZNF443

31

Q9Y2A4
IQRVVSMAALAMVCE

TARBP1

806

Q13395
ELEVMLCGMQEVDLA

WWP1

796

Q9H0M0