Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	UTP binding	CAD HSP90AB1	1.02e-04	4	83	2	GO:0002134
GeneOntologyMolecularFunction	pyrimidine ribonucleotide binding	CAD HSP90AB1	1.69e-04	5	83	2	GO:0032557
GeneOntologyMolecularFunction	histone H3K4me/H3K4me2/H3K4me3 demethylase activity	KDM5C KDM5D	2.53e-04	6	83	2	GO:0034647
GeneOntologyMolecularFunction	histone H3K4 demethylase activity	KDM5C KDM5D	4.70e-04	8	83	2	GO:0032453
GeneOntologyBiologicalProcess	homophilic cell adhesion via plasma membrane adhesion molecules	FAT2 PCDHGA11 PCDHGA10 PCDHGA5 CNTN5 DCHS1 ROBO3	9.64e-06	187	82	7	GO:0007156
Domain	MITF_TFEB_C_3_N	TFEB TFE3	5.98e-05	3	84	2	PF15951
Domain	MiT/TFE_N	TFEB TFE3	5.98e-05	3	84	2	IPR031867
Domain	Lys_sp_deMease-like_dom	KDM5C KDM5D	1.19e-04	4	84	2	IPR013637
Domain	DUF3371	TFEB TFE3	1.19e-04	4	84	2	PF11851
Domain	PLU-1	KDM5C KDM5D	1.19e-04	4	84	2	PF08429
Domain	MiT/TFE_C	TFEB TFE3	1.19e-04	4	84	2	IPR021802
Domain	Cadherin_CS	FAT2 PCDHGA11 PCDHGA10 PCDHGA5 DCHS1	1.32e-04	109	84	5	IPR020894
Domain	CADHERIN_1	FAT2 PCDHGA11 PCDHGA10 PCDHGA5 DCHS1	1.57e-04	113	84	5	PS00232
Domain	Cadherin	FAT2 PCDHGA11 PCDHGA10 PCDHGA5 DCHS1	1.57e-04	113	84	5	PF00028
Domain	CADHERIN_2	FAT2 PCDHGA11 PCDHGA10 PCDHGA5 DCHS1	1.63e-04	114	84	5	PS50268
Domain	-	FAT2 PCDHGA11 PCDHGA10 PCDHGA5 DCHS1	1.63e-04	114	84	5	2.60.40.60
Domain	CA	FAT2 PCDHGA11 PCDHGA10 PCDHGA5 DCHS1	1.70e-04	115	84	5	SM00112
Domain	Cadherin-like	FAT2 PCDHGA11 PCDHGA10 PCDHGA5 DCHS1	1.77e-04	116	84	5	IPR015919
Domain	Cadherin	FAT2 PCDHGA11 PCDHGA10 PCDHGA5 DCHS1	1.92e-04	118	84	5	IPR002126
Domain	zf-C5HC2	KDM5C KDM5D	1.98e-04	5	84	2	PF02928
Domain	Znf_C5HC2	KDM5C KDM5D	1.98e-04	5	84	2	IPR004198
Domain	Cadherin_tail	PCDHGA11 PCDHGA10 PCDHGA5	6.11e-04	37	84	3	PF15974
Domain	Cadherin_CBD	PCDHGA11 PCDHGA10 PCDHGA5	6.11e-04	37	84	3	IPR031904
Domain	BTB	ZBTB43 ZBTB10 KCTD11 ZBTB3 KLHL32	7.76e-04	160	84	5	PS50097
Domain	JmjN	KDM5C KDM5D	8.79e-04	10	84	2	SM00545
Domain	JMJN	KDM5C KDM5D	8.79e-04	10	84	2	PS51183
Domain	JmjN	KDM5C KDM5D	8.79e-04	10	84	2	PF02375
Domain	JmjN	KDM5C KDM5D	8.79e-04	10	84	2	IPR003349
Domain	Cadherin_C	PCDHGA11 PCDHGA10 PCDHGA5	8.88e-04	42	84	3	IPR032455
Domain	Cadherin_C_2	PCDHGA11 PCDHGA10 PCDHGA5	8.88e-04	42	84	3	PF16492
Domain	BTB/POZ_dom	ZBTB43 ZBTB10 KCTD11 ZBTB3 KLHL32	1.48e-03	185	84	5	IPR000210
Domain	SKP1/BTB/POZ	ZBTB43 ZBTB10 KCTD11 ZBTB3 KLHL32	1.63e-03	189	84	5	IPR011333
Domain	-	KDM5C KDM5D	2.02e-03	15	84	2	1.10.150.60
Domain	BRIGHT	KDM5C KDM5D	2.02e-03	15	84	2	SM00501
Domain	ARID_dom	KDM5C KDM5D	2.02e-03	15	84	2	IPR001606
Domain	ARID	KDM5C KDM5D	2.02e-03	15	84	2	PS51011
Domain	-	GBF1 PSD4	2.02e-03	15	84	2	1.10.1000.11
Domain	ARID	KDM5C KDM5D	2.02e-03	15	84	2	PF01388
Domain	Sec7	GBF1 PSD4	2.02e-03	15	84	2	PF01369
Domain	Sec7_alpha_orthog	GBF1 PSD4	2.02e-03	15	84	2	IPR023394
Domain	Sec7	GBF1 PSD4	2.30e-03	16	84	2	SM00222
Domain	SEC7	GBF1 PSD4	2.30e-03	16	84	2	PS50190
Domain	Sec7_dom	GBF1 PSD4	2.30e-03	16	84	2	IPR000904
Domain	BTB	ZBTB43 ZBTB10 ZBTB3 KLHL32	2.89e-03	131	84	4	PF00651
Domain	Cadherin_2	PCDHGA11 PCDHGA10 PCDHGA5	3.14e-03	65	84	3	PF08266
Domain	Cadherin_N	PCDHGA11 PCDHGA10 PCDHGA5	3.14e-03	65	84	3	IPR013164
Domain	PDZ	INTU AHNAK DLG1 PARD3	4.47e-03	148	84	4	SM00228
Pubmed	An expanded Oct4 interaction network: implications for stem cell biology, development, and disease.	TFEB CAD ZBTB43 NFRKB ZBTB10 ZFHX3 XRCC5 TFE3	5.94e-11	91	84	8	20362542
Pubmed	Dynamic patterns of histone H3 lysine 4 methyltransferases and demethylases during mouse preimplantation development.	KDM5C SETD7 KDM5D	3.82e-06	13	84	3	24619213
Pubmed	Molecular genetics and cellular features of TFE3 and TFEB fusion kidney cancers.	TFEB TFE3	5.76e-06	2	84	2	25048860
Pubmed	TFEB and TFE3: The art of multi-tasking under stress conditions.	TFEB TFE3	5.76e-06	2	84	2	27892768
Pubmed	Diagnostic utility of one-stop fusion gene panel to detect TFE3/TFEB gene rearrangement and amplification in renal cell carcinomas.	TFEB TFE3	5.76e-06	2	84	2	34148064
Pubmed	TFEB and TFE3 are novel components of the integrated stress response.	TFEB TFE3	5.76e-06	2	84	2	26813791
Pubmed	Translocation renal cell carcinomas in adults: a single-institution experience.	TFEB TFE3	5.76e-06	2	84	2	22446944
Pubmed	TFEB and TFE3 cooperate in the regulation of the innate immune response in activated macrophages.	TFEB TFE3	5.76e-06	2	84	2	27171064
Pubmed	Mouse H-Y encoding Smcy gene and its X chromosomal homolog Smcx.	KDM5C KDM5D	5.76e-06	2	84	2	10441747
Pubmed	Inefficient purifying selection: the mammalian Y chromosome in the rodent genus Mus.	KDM5C KDM5D	5.76e-06	2	84	2	16416087
Pubmed	Impaired TFEB-mediated lysosomal biogenesis promotes the development of pancreatitis in mice and is associated with human pancreatitis.	TFEB TFE3	5.76e-06	2	84	2	30894069
Pubmed	TFEB/3 Govern Repair Schwann Cell Generation and Function Following Peripheral Nerve Injury.	TFEB TFE3	5.76e-06	2	84	2	39054068
Pubmed	Mutations of histone demethylase genes encoded by X and Y chromosomes, Kdm5c and Kdm5d, lead to noncompaction cardiomyopathy in mice.	KDM5C KDM5D	5.76e-06	2	84	2	32081420
Pubmed	Targeting of VPS18 by the lysosomotropic agent RDN reverses TFE3-mediated drug resistance.	VPS18 TFE3	5.76e-06	2	84	2	34099617
Pubmed	Association of CILP2 and ACE gene polymorphisms with cardiovascular risk factors in Slovak midlife women.	CILP2 ACE	5.76e-06	2	84	2	24350279
Pubmed	Analysis of mutation rates in the SMCY/SMCX genes shows that mammalian evolution is male driven.	KDM5C KDM5D	5.76e-06	2	84	2	9060413
Pubmed	Transcription factor EB and TFE3: new metabolic coordinators mediating adaptive responses to exercise in skeletal muscle?	TFEB TFE3	5.76e-06	2	84	2	32830550
Pubmed	TFEB- and TFE3-dependent autophagy activation supports cancer proliferation in the absence of centrosomes.	TFEB TFE3	5.76e-06	2	84	2	35316161
Pubmed	TFE3 regulates whole-body energy metabolism in cooperation with TFEB.	TFEB TFE3	5.76e-06	2	84	2	28283651
Pubmed	TFE3 contains two activation domains, one acidic and the other proline-rich, that synergistically activate transcription.	TFEB TFE3	5.76e-06	2	84	2	7479029
Pubmed	A mouse Y chromosome gene encoded by a region essential for spermatogenesis and expression of male-specific minor histocompatibility antigens.	KDM5C KDM5D	5.76e-06	2	84	2	7524912
Pubmed	Maintenance of neural stem-progenitor cells by the lysosomal biosynthesis regulators TFEB and TFE3 in the embryonic mouse telencephalon.	TFEB TFE3	5.76e-06	2	84	2	33609411
Pubmed	A regulatory circuit that involves HR23B and HDAC6 governs the biological response to HDAC inhibitors.	CAD GBF1 XRCC5 HSP90AB1	6.70e-06	50	84	4	23703321
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	INTU AMER1 PCDHGA11 PCDHGA10 PCDHGA5 AHNAK CC2D2A DLG1 ALDH2 XRCC5 CFAP46 ABCB4 RPS6KC1 HSP90AB1	8.73e-06	1442	84	14	35575683
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	RHBDL2 AMER1 FAM168A NFRKB OBSCN ZBTB10 CRYBG1 DLG1 PARD3 CPLANE1 KLHL32 RPS6KC1	1.13e-05	1084	84	12	11544199
Pubmed	A crucial role for Arf6 in the response of commissural axons to Slit.	GBF1 ROBO3 PSD4	1.28e-05	19	84	3	30674481
Pubmed	RagD auto-activating mutations impair MiT/TFE activity in kidney tubulopathy and cardiomyopathy syndrome.	TFEB TFE3	1.73e-05	3	84	2	37188688
Pubmed	Acetyltransferase GCN5 regulates autophagy and lysosome biogenesis by targeting TFEB.	TFEB TFE3	1.73e-05	3	84	2	31750630
Pubmed	Identification of a mouse male-specific transplantation antigen, H-Y.	KDM5C KDM5D	1.73e-05	3	84	2	7544442
Pubmed	The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis.	TFEB TFE3	1.73e-05	3	84	2	22692423
Pubmed	Cathepsin-K immunoreactivity distinguishes MiTF/TFE family renal translocation carcinomas from other renal carcinomas.	TFEB TFE3	1.73e-05	3	84	2	19396149
Pubmed	MiT/TFE factors control ER-phagy via transcriptional regulation of FAM134B.	TFEB TFE3	1.73e-05	3	84	2	32716134
Pubmed	Transcription factors TFE3 and TFEB are critical for CD40 ligand expression and thymus-dependent humoral immunity.	TFEB TFE3	1.73e-05	3	84	2	16936731
Pubmed	Transcriptional activation of RagD GTPase controls mTORC1 and promotes cancer growth.	TFEB TFE3	1.73e-05	3	84	2	28619945
Pubmed	Neurodegenerative VPS41 variants inhibit HOPS function and mTORC1-dependent TFEB/TFE3 regulation.	TFEB TFE3	1.73e-05	3	84	2	33851776
Pubmed	MITF and TFEB cross-regulation in melanoma cells.	TFEB TFE3	1.73e-05	3	84	2	32881934
Pubmed	TFEB and TFE3 drive kidney cystogenesis and tumorigenesis.	TFEB TFE3	1.73e-05	3	84	2	36987696
Pubmed	The transcription factors TFE3 and TFEB amplify p53 dependent transcriptional programs in response to DNA damage.	TFEB TFE3	1.73e-05	3	84	2	30520728
Pubmed	Nutrient-sensitive transcription factors TFEB and TFE3 couple autophagy and metabolism to the peripheral clock.	TFEB TFE3	1.73e-05	3	84	2	31126958
Pubmed	Tfe3 and Tfeb Transcriptionally Regulate Peroxisome Proliferator-Activated Receptor γ2 Expression in Adipocytes and Mediate Adiponectin and Glucose Levels in Mice.	TFEB TFE3	1.73e-05	3	84	2	28483914
Pubmed	A striking organization of a large family of human neural cadherin-like cell adhesion genes.	FAT2 PCDHGA11 PCDHGA10 PCDHGA5	2.87e-05	72	84	4	10380929
Pubmed	Novel JARID1C/SMCX mutations in patients with X-linked mental retardation.	KDM5C KDM5D	3.45e-05	4	84	2	16541399
Pubmed	Cloning and characterization of the murine genes for bHLH-ZIP transcription factors TFEC and TFEB reveal a common gene organization for all MiT subfamily members.	TFEB TFE3	3.45e-05	4	84	2	10036191
Pubmed	The ciliopathy-associated CPLANE proteins direct basal body recruitment of intraflagellar transport machinery.	INTU CPLANE1	3.45e-05	4	84	2	27158779
Pubmed	Dectin-1/CARD9 induction of the TFEB and TFE3 gene network is dispensable for phagocyte anti-Aspergillus activity in the lung.	TFEB TFE3	3.45e-05	4	84	2	37861312
Pubmed	TFEB regulates lysosomal positioning by modulating TMEM55B expression and JIP4 recruitment to lysosomes.	TFEB TFE3	3.45e-05	4	84	2	29146937
Pubmed	The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases.	KDM5C KDM5D	3.45e-05	4	84	2	17320160
Pubmed	Mitf and Tfe3, two members of the Mitf-Tfe family of bHLH-Zip transcription factors, have important but functionally redundant roles in osteoclast development.	TFEB TFE3	3.45e-05	4	84	2	11930005
Pubmed	Renal carcinoma-associated transcription factors TFE3 and TFEB are leukemia inhibitory factor-responsive transcription activators of E-cadherin.	TFEB TFE3	3.45e-05	4	84	2	15994295
Pubmed	X- and Y-Linked Chromatin-Modifying Genes as Regulators of Sex-Specific Cancer Incidence and Prognosis.	KDM5C KDM5D	3.45e-05	4	84	2	32732223
Pubmed	A novel X gene with a widely transcribed Y-linked homologue escapes X-inactivation in mouse and human.	KDM5C KDM5D	3.45e-05	4	84	2	7951230
Pubmed	TFEB and TFE3 control glucose homeostasis by regulating insulin gene expression.	TFEB TFE3	3.45e-05	4	84	2	37712288
Pubmed	Activation of Tripartite Motif Containing 63 Expression by Transcription Factor EB and Transcription Factor Binding to Immunoglobulin Heavy Chain Enhancer 3 Is Regulated by Protein Kinase D and Class IIa Histone Deacetylases.	TFEB TFE3	3.45e-05	4	84	2	33519497
Pubmed	Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members.	FAT2 PCDHGA11 PCDHGA10 PCDHGA5	3.75e-05	77	84	4	10835267
Pubmed	Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes.	FAT2 PCDHGA11 PCDHGA10 PCDHGA5	4.35e-05	80	84	4	10716726
Pubmed	AMPK-SKP2-CARM1 signalling cascade in transcriptional regulation of autophagy.	TFEB TFE3	5.74e-05	5	84	2	27309807
Pubmed	mTORC1-independent TFEB activation via Akt inhibition promotes cellular clearance in neurodegenerative storage diseases.	TFEB TFE3	5.74e-05	5	84	2	28165011
Pubmed	Sumoylation of MITF and its related family members TFE3 and TFEB.	TFEB TFE3	5.74e-05	5	84	2	15507434
Pubmed	A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies.	TGM1 CAD AHNAK ZBTB10 RYR3 HSP90AB1	6.70e-05	284	84	6	29459677
Pubmed	Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells.	TFEB AHNAK NFRKB EML2 XRCC5	7.20e-05	177	84	5	26206133
Pubmed	Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies.	ZFHX3 ALDH2	8.59e-05	6	84	2	23041239
Pubmed	GEP100 links epidermal growth factor receptor signalling to Arf6 activation to induce breast cancer invasion.	GBF1 PSD4	1.20e-04	7	84	2	18084281
Pubmed	Expression of mouse dchs1, fjx1, and fat-j suggests conservation of the planar cell polarity pathway identified in Drosophila.	FAT2 DCHS1	1.20e-04	7	84	2	16059920
Pubmed	Mice lacking HSP90beta fail to develop a placental labyrinth.	TFEB HSP90AB1	1.20e-04	7	84	2	10654595
Pubmed	Testing genetic susceptibility loci for alcoholic heart muscle disease.	ALDH2 ACE	1.20e-04	7	84	2	11696658
Pubmed	Direct binding of CoREST1 to SUMO-2/3 contributes to gene-specific repression by the LSD1/CoREST1/HDAC complex.	CAD AHNAK XRCC5 HSP90AB1	1.30e-04	106	84	4	19394292
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	CAD GBF1 AHNAK CRYBG1 XRCC5	1.34e-04	202	84	5	33005030
Pubmed	Genome-wide association study of the child behavior checklist dysregulation profile.	TMEM132D NUDT22	1.60e-04	8	84	2	21784300
Pubmed	Genotype announcement in a genetic polymorphism study for health checkup examinees at Nagoya University Hospital.	ALDH2 ACE	1.60e-04	8	84	2	15279067
Pubmed	The bHLH-Zip transcription factor Tfeb is essential for placental vascularization.	TFEB TFE3	1.60e-04	8	84	2	9806910
Pubmed	Alterations in the brain interactome of the intrinsically disordered N-terminal domain of the cellular prion protein (PrPC) in Alzheimer's disease.	NAE1 APEH DLG1 SETD7 XRCC5 CNDP1	1.82e-04	341	84	6	29791485
Pubmed	TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.	RBM12 SNW1 ZBTB10 ZFHX3 XRCC5	1.99e-04	220	84	5	35785414
Pubmed	AMPK Interactome Reveals New Function in Non-homologous End Joining DNA Repair.	AMER1 ZFHX3 XRCC5 CFAP46	2.17e-04	121	84	4	31900314
Pubmed	Identification of Jmjd3 as an Essential Epigenetic Regulator of Hox Gene Temporal Collinear Activation for Body Axial Patterning in Mice.	KDM5C SETD7 KDM5D	2.31e-04	49	84	3	34368113
Pubmed	Sex differences in environmental and genetic factors for hypertension.	ALDH2 ACE	2.56e-04	10	84	2	18724972
Pubmed	KSHV episome tethering sites on host chromosomes and regulation of latency-lytic switch by CHD4.	CAD RBM12 SNW1 AHNAK	2.85e-04	130	84	4	35545047
Pubmed	Reprogramming tumour-associated macrophages to outcompete cancer cells.	TFEB TFE3	3.13e-04	11	84	2	37380769
Pubmed	Microsatellite scan identifies new candidate genes for susceptibility to alcoholic chronic pancreatitis in Japanese patients.	ALDH2 RYR3	3.13e-04	11	84	2	19096130
Pubmed	Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.	TFEB VPS13D CSRNP3 MTFR1 DLG1 ZFHX3 PARD3	3.23e-04	536	84	7	15840001
Pubmed	Exchangeable gene trap using the Cre/mutated lox system.	TFEB VPS13D CSRNP3 MTFR1 DLG1 ZFHX3 PARD3	3.31e-04	538	84	7	10512203
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	TFEB GBF1 AHNAK OBSCN APEH EML2 SUFU FEM1A TFE3 THAP11	3.31e-04	1105	84	10	35748872
Pubmed	TRIM21 ameliorates hepatic glucose and lipid metabolic disorders in type 2 diabetes mellitus by ubiquitination of PEPCK1 and FASN.	CAD P3H2 AHNAK SPRYD3 XRCC5 HSP90AB1	3.34e-04	382	84	6	37249651
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	INTU KDM5C NFRKB ZBTB10 HLCS ECT2L ZFHX3 SIRPB1 CLSPN PARD3	3.57e-04	1116	84	10	31753913
Pubmed	Proteomic analysis of the NOS2 interactome in human airway epithelial cells.	CAD COPRS XRCC5 HSP90AB1	3.58e-04	138	84	4	23438482
Pubmed	New nomenclature for chromatin-modifying enzymes.	KDM5C SETD7 KDM5D	3.62e-04	57	84	3	18022353
Pubmed	Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.	CAD GBF1 PARD3 TFE3 HSP90AB1	3.92e-04	255	84	5	15324660
Pubmed	Identification of phagocytosis regulators using magnetic genome-wide CRISPR screens.	TFEB CAD CRYBG1 APOBR	4.10e-04	143	84	4	30397336
Pubmed	Sex differences in structure and expression of the sex chromosome genes CHD1Z and CHD1W in zebra finches.	KDM5C KDM5D	4.42e-04	13	84	2	14660691
Pubmed	Formation of the Mouse Internal Capsule and Cerebral Peduncle: A Pioneering Role for Striatonigral Axons as Revealed in Isl1 Conditional Mutants.	CNTN5 ZFHX3	4.42e-04	13	84	2	35273083
Pubmed	The Rab7 effector PLEKHM1 binds Arl8b to promote cargo traffic to lysosomes.	VPS18 SNW1	4.42e-04	13	84	2	28325809
Pubmed	ZBTB20 is crucial for the specification of a subset of callosal projection neurons and astrocytes in the mammalian neocortex.	ZBTB43 ZBTB10 ZBTB3	4.86e-04	63	84	3	34351428
Pubmed	A central role for regulated protein stability in the control of TFE3 and MITF by nutrients.	TFEB TFE3	5.15e-04	14	84	2	36608670
Pubmed	Selection system for genes encoding nuclear-targeted proteins.	RBM12 THAP11	5.15e-04	14	84	2	9853615
Pubmed	The Tumor Suppressor CIC Directly Regulates MAPK Pathway Genes via Histone Deacetylation.	CAD SNW1 ZBTB43 ZBTB10 ZFHX3 XRCC5 HSP90AB1	5.33e-04	583	84	7	29844126
Pubmed	Proteomic Analysis of the EWS-Fli-1 Interactome Reveals the Role of the Lysosome in EWS-Fli-1 Turnover.	FAM168A COPRS NFRKB XRCC5 ACE TFE3	5.85e-04	425	84	6	24999758
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	AMER1 MTFR1 AHNAK APEH DLG1 ZFHX3 CLSPN PARD3	5.86e-04	777	84	8	35844135
Pubmed	Pals1 is a major regulator of the epithelial-like polarization and the extension of the myelin sheath in peripheral nerves.	DLG1 PARD3	5.93e-04	15	84	2	20237282
Pubmed	Maturation of postnatally generated olfactory bulb granule cells depends on functional γ-protocadherin expression.	PCDHGA11 PCDHGA10	5.93e-04	15	84	2	23515096
Pubmed	Evolutionary strata on the mouse X chromosome correspond to strata on the human X chromosome.	KDM5C KDM5D	5.93e-04	15	84	2	14762062
Pubmed	Comparative DNA sequence analysis of mouse and human protocadherin gene clusters.	PCDHGA11 PCDHGA10 PCDHGA5	6.08e-04	68	84	3	11230163
Cytoband	15q14-q15	VPS18 RYR3	3.30e-05	5	84	2	15q14-q15
GeneFamily	Basic leucine zipper proteins\|BTB domain containing	ZBTB43 ZBTB10 ZBTB3 KLHL32	7.86e-04	134	56	4	861
GeneFamily	AT-rich interaction domain containing	KDM5C KDM5D	9.64e-04	15	56	2	418
GeneFamily	Clustered protocadherins	PCDHGA11 PCDHGA10 PCDHGA5	1.03e-03	64	56	3	20
GeneFamily	Cadherin related	FAT2 DCHS1	1.24e-03	17	56	2	24
GeneFamily	PDZ domain containing	INTU AHNAK DLG1 PARD3	1.26e-03	152	56	4	1220
GeneFamily	PHD finger proteins\|Lysine demethylases	KDM5C KDM5D	2.49e-03	24	56	2	485
Disease	alcohol use disorder (implicated_via_orthology)	RHBDL2 KDM5C CLIC6 KDM5D RYR3 PSD4	1.91e-05	195	83	6	DOID:1574 (implicated_via_orthology)
Disease	Colorectal Carcinoma	VPS18 CAD HOXD9 CSRNP3 OBSCN DCHS1 EML2 ALDH2 ABCC6 ABCB4	2.78e-05	702	83	10	C0009402
Disease	trans fatty acid measurement, trans/trans-18:2 fatty acid measurement	INTU CNTN5 RYR3	4.16e-05	24	83	3	EFO_0006821, EFO_0006826
Disease	syndromic X-linked intellectual disability Claes-Jensen type (implicated_via_orthology)	KDM5C KDM5D	4.67e-05	4	83	2	DOID:0060809 (implicated_via_orthology)
Disease	childhood trauma measurement, alcohol consumption measurement	INTU PCDHGA11 PCDHGA10 PCDHGA5	4.90e-05	71	83	4	EFO_0007878, EFO_0007979
Disease	Sudden death	SCN10A ACE	7.77e-05	5	83	2	C0011071
Disease	MiT family translocation renal cell carcinoma	TFEB TFE3	1.63e-04	7	83	2	C4518356
Disease	familial sick sinus syndrome	SCN10A ZFHX3	2.16e-04	8	83	2	MONDO_0012061
Disease	sick sinus syndrome	SCN10A ZFHX3	2.16e-04	8	83	2	MONDO_0001823
Disease	mitral valve prolapse (is_implicated_in)	DCHS1 ACE	2.78e-04	9	83	2	DOID:988 (is_implicated_in)
Disease	cholestasis (implicated_via_orthology)	VPS18 ABCB4	2.78e-04	9	83	2	DOID:13580 (implicated_via_orthology)
Disease	cholestasis (biomarker_via_orthology)	XDH ACE ABCB4	3.60e-04	49	83	3	DOID:13580 (biomarker_via_orthology)
Disease	stroke	FAT2 CRYBG1 ZFHX3 ALDH2	7.41e-04	144	83	4	EFO_0000712
Disease	phosphatidylcholine 36:3 measurement	TMEM132D F9	8.02e-04	15	83	2	EFO_0010381
Disease	syndromic intellectual disability (implicated_via_orthology)	KDM5C KDM5D	9.14e-04	16	83	2	DOID:0050888 (implicated_via_orthology)
Disease	lysosomal storage disease (implicated_via_orthology)	TFEB TFE3	9.14e-04	16	83	2	DOID:3211 (implicated_via_orthology)
Disease	gout, hyperuricemia	CNTN5 ALDH2	9.14e-04	16	83	2	EFO_0004274, EFO_0009104
Disease	Non-alcoholic Fatty Liver Disease	ALDH2 ACE ABCB4	1.03e-03	70	83	3	C0400966
Disease	Nonalcoholic Steatohepatitis	ALDH2 ACE ABCB4	1.03e-03	70	83	3	C3241937
Disease	renal fibrosis (implicated_via_orthology)	XDH ACE	1.03e-03	17	83	2	DOID:0050855 (implicated_via_orthology)
Disease	Disease Exacerbation	FAM168A CRYBG1 ABCC6 ABCB4	1.23e-03	165	83	4	C0235874
Disease	intellectual disability (implicated_via_orthology)	KANSL1L KDM5C KDM5D	1.25e-03	75	83	3	DOID:1059 (implicated_via_orthology)
Disease	Familial aplasia of the vermis	CC2D2A CPLANE1	1.44e-03	20	83	2	cv:C0431399
Disease	hepatocellular carcinoma (is_implicated_in)	ZFHX3 ALDH2 ACE RYR3	1.73e-03	181	83	4	DOID:684 (is_implicated_in)
Disease	mean reticulocyte volume	INTU CAD PCDHGA5 CNTN5 CC2D2A SLC12A7 ABCB4 HSP90AB1	1.84e-03	799	83	8	EFO_0010701
Disease	Sarcosine measurement	PCDHGA5 CNTN5	1.90e-03	23	83	2	EFO_0021668
Disease	sciatic neuropathy (implicated_via_orthology)	SNW1 SCN10A	1.90e-03	23	83	2	DOID:11446 (implicated_via_orthology)
Disease	creatinine measurement	TFEB INTU CILP2 OBSCN DLG1 ZFHX3 PARD3 SUFU PSD4	1.92e-03	995	83	9	EFO_0004518
Disease	pulmonary embolism	TMEM132D RPS6KC1	2.25e-03	25	83	2	EFO_0003827
Disease	mental development measurement	PCDHGA10 PCDHGA5	2.25e-03	25	83	2	EFO_0008230
Disease	acute kidney failure (implicated_via_orthology)	XDH ACE	2.62e-03	27	83	2	DOID:3021 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
GANPGFHEAIGDVLA	ACE	411	P12821
FSIAGGTDNPHIGDD	DLG1	236	Q12959
NGETGRDLDGTSFPH	CFAP46	1586	Q8IYW2
EVGFHGAAPDISVKG	AHNAK	5531	Q09666
EAAHGPEDVVSEGTG	AMER1	101	Q5JTC6
EGGHVDFFVPLGASE	ECT2L	386	Q008S8
TRGAHGETEAEEGAP	CLIC6	76	Q96NY7
HLAEEGPAEGSGEAA	CLIC6	416	Q96NY7
GQPIDFEEEGGHFES	CNTN5	611	O94779
GIPSAGGEEHAFLTV	RBM12	696	Q9NTZ6
ASEPGLFAVGLHTGE	PCDHGA5	611	Q9Y5G8
KASEPGLFAVGEHTG	PCDHGA11	611	Q9Y5H2
DGGAHPELGSAFVTV	DCHS1	336	Q96JQ0
GRSGGHSLSPEENEF	PODN	31	Q7Z5L7
AGGSFTVRADHGEPI	HSP90AB1	161	P08238
AFHGEIFGTSVPENG	KANSL1L	946	A0AUZ9
GTEGTFHLPVDTGTE	FAM168A	76	Q92567
HGFESVVGPVKGVFD	NFRKB	541	Q6P4R8
GGPEAHESTGIFFVE	NUDT22	241	Q9BRQ3
GAGVAGVEDIKSHPF	RPS6KC1	1041	Q96S38
GADIHSKEFGSGFPV	KDM5D	431	Q9BY66
FHTTFVGPGGEVISD	KCNH5	266	Q8NCM2
GGEVVTVHPDGNSFD	HLCS	701	P50747
DGFVEGLGTHAEVVP	CSRNP3	391	Q8WYN3
VESVEVVGGDPGKHF	FAT2	286	Q9NYQ8
EETLGRHFSVGAPDG	FAT2	3571	Q9NYQ8
SEPGLFAVGEHTGEV	PCDHGA10	616	Q9Y5H3
FAPSGHIEGFTAEIG	FAM214B	361	Q7L5A3
SGGPHVTEVEGTSFL	F9	411	P00740
SPARGEGTHSEEEGF	COPRS	66	Q9NQ92
IGHEGDEVFAARFGP	HOXD9	26	P28356
VPSGVNVEGAEVHGF	P3H2	411	Q8IVL5
AGFEDGVIVEQGSHS	ABCB4	601	P21439
EGGEDDGFSPHTTPD	INTU	721	Q9ULD6
GVTPEDAGTVSFHLG	OBSCN	4221	Q5VST9
SHPGEDAVASFADVG	MTFR1	66	Q15390
TLDHEGVGSGVPFSF	CC2D2A	771	Q9P2K1
HPFGVGGVDSVSEST	CPLANE1	3151	Q9H799
SHGDVVFAGDGIEGS	FUT2	256	Q10981
GEGALPHEFLEGVEG	B3GALNT2	256	Q8NCR0
PHEFLEGVEGVAGGF	B3GALNT2	261	Q8NCR0
ASVEAGGSVHFDGET	FEM1A	66	Q9BSK4
GGSVHFDGETIEGAP	FEM1A	71	Q9BSK4
AEIFHSADARGGGPS	GBF1	1681	Q92538
DFGPVRTVAEGHGDT	EML2	336	O95834
GGETEEATGDDHLPF	CRYBG1	1246	Q9Y4K1
GHGFITPENGSEDIF	CSDC2	81	Q9Y534
AGGIGPTHDDVTFEA	FLAD1	176	Q8NFF5
TVVPVEAHADGGGDE	SLC12A7	6	Q9Y666
EPGFGSSLAFVGAEH	IKZF4	366	Q9H2S9
REAEHGPEVSSGEGT	MTBP	21	Q96DY7
VAVFDEQDPHHGGDG	PARD3	76	Q8TEW0
FGVASGDRAEGSPHF	KCTD11	141	Q693B1
FSHSLSFGGREDEGP	TFEB	396	P19484
DGSPVSFAAHIAGGF	RHBDL2	241	Q9NX52
TQFVAEAAGPGGHLA	TMEM132D	581	Q14C87
DSFPEGIHTSIGEQG	ABCC6	736	O95255
ESEPDLGDGAAISGH	PSD4	301	Q8NDX1
AVEGHLDDDGLPHGF	SETD7	11	Q8WTS6
GSPDHVEFKSGAGTE	SIRPB1	126	Q5TFQ8
HDGDSVVFAGPAGNS	APEH	71	P13798
FGPTAGAAIASHEDV	ALDH2	241	P05091
PHISAAGAGEALEGV	APOBR	771	Q0VD83
DHPGGDGDFESLAAI	CILP2	66	Q8IUL8
SLSIHGIEGAFDEPG	CNDP1	346	Q96KN2
GGLVAFEPHALEGEG	CLSPN	446	Q9HAW4
LVESFELGSGGHTDF	ZBTB43	151	O43298
GHDPSSGVQEFISGI	URGCP	541	Q8TCY9
DDGKIFHGSGVGDPF	SPRYD3	301	Q8NCJ5
IEEEGRPGAATFHVG	TFE3	466	P19532
SGAHIRDPVGGSVEF	RYR3	1706	Q15413
DPSVFGEHSAGTEEG	RYR3	1751	Q15413
TDDGVFPGDHESHRG	SCN10A	521	Q9Y5Y9
TIDPAGEELQTFHGG	ROBO3	1021	Q96MS0
QGHIFEAELSASEGG	VPS18	166	Q9P253
DNRVHEFTGTDGPSG	SUFU	101	Q9UMX1
DGPTEESALIGHFCG	TLL2	526	Q9Y6L7
ELNSVEHGPDGISFG	XDH	286	P47989
EDFGDGGAFPEIHVA	SNW1	56	Q13573
EPGGTHKEDFASGTA	CAD	1476	P27708
FSDAGGDSHLGETIP	TGM1	796	P22735
SGVGAGEGETVQHFP	ZBTB10	221	Q96DT7
GAAEPHTIAAFLGGA	NAE1	486	Q13564
VVGEEGFPDTGSDHS	THAP11	231	Q96EK4
PSGDTAAVFEEGGDV	XRCC5	711	P13010
NESTEGDDGGFVPHH	ZFHX3	606	Q15911
GVVPEGNGTFLDDTH	VPS13D	2921	Q5THJ4
GAAGLEEVGPSDHFL	ZBTB3	401	Q9H5J0
DFLFVAGGEVEHASG	KLHL32	346	Q96NJ5
GADIHSKEFGSGFPV	KDM5C	441	P41229