Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	peptide lactyltransferase (CoA-dependent) activity	CREBBP EP300	4.97e-06	2	45	2	GO:0120300
GeneOntologyMolecularFunction	histone H3K27 acetyltransferase activity	CREBBP EP300	4.97e-06	2	45	2	GO:0044017
GeneOntologyMolecularFunction	histone H3K18 acetyltransferase activity	CREBBP EP300	1.49e-05	3	45	2	GO:0043993
GeneOntologyMolecularFunction	lncRNA binding	CELF1 CELF2 STAT3	6.66e-05	35	45	3	GO:0106222
GeneOntologyMolecularFunction	histone acetyltransferase activity	NCOA1 CREBBP EP300	2.06e-04	51	45	3	GO:0004402
GeneOntologyMolecularFunction	peptide-lysine-N-acetyltransferase activity	NCOA1 CREBBP EP300	2.59e-04	55	45	3	GO:0061733
GeneOntologyMolecularFunction	interleukin-1 binding	A2M NLRP2	3.23e-04	12	45	2	GO:0019966
GeneOntologyMolecularFunction	peptide N-acetyltransferase activity	NCOA1 CREBBP EP300	3.35e-04	60	45	3	GO:0034212
GeneOntologyMolecularFunction	pre-mRNA binding	CELF1 CELF2 EP300	4.05e-04	64	45	3	GO:0036002
GeneOntologyMolecularFunction	histone H3 acetyltransferase activity	CREBBP EP300	5.12e-04	15	45	2	GO:0010484
GeneOntologyMolecularFunction	chromatin DNA binding	FOXO3 CREBBP EP300 STAT3	5.38e-04	167	45	4	GO:0031490
GeneOntologyMolecularFunction	transcription coactivator activity	NCOA1 KMT2C WWTR1 CREBBP EP300	5.78e-04	303	45	5	GO:0003713
GeneOntologyMolecularFunction	p53 binding	PSME3 CREBBP EP300	6.96e-04	77	45	3	GO:0002039
GeneOntologyMolecularFunction	N-acetyltransferase activity	NCOA1 CREBBP EP300	7.23e-04	78	45	3	GO:0008080
GeneOntologyMolecularFunction	nuclear glucocorticoid receptor binding	EP300 STAT3	9.20e-04	20	45	2	GO:0035259
GeneOntologyMolecularFunction	peroxisome proliferator activated receptor binding	CREBBP EP300	1.01e-03	21	45	2	GO:0042975
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ZNF675 FOXO3 NCOA1 ZNF431 KLF8 RFX7 NACC1 CREBBP EP300 STAT3	1.26e-03	1459	45	10	GO:0000977
GeneOntologyMolecularFunction	N-acyltransferase activity	NCOA1 CREBBP EP300	1.57e-03	102	45	3	GO:0016410
GeneOntologyMolecularFunction	acetyltransferase activity	NCOA1 CREBBP EP300	1.66e-03	104	45	3	GO:0016407
GeneOntologyMolecularFunction	histone modifying activity	NCOA1 KMT2C CREBBP EP300	1.74e-03	229	45	4	GO:0140993
GeneOntologyMolecularFunction	bHLH transcription factor binding	CREBBP EP300	3.15e-03	37	45	2	GO:0043425
GeneOntologyMolecularFunction	transcription coregulator binding	FOXO3 CREBBP EP300	3.86e-03	140	45	3	GO:0001221
GeneOntologyMolecularFunction	protein-macromolecule adaptor activity	NCOA1 KMT2C ZSWIM8 WWTR1 CREBBP EP300 STAT3 TNRC6A	3.99e-03	1160	45	8	GO:0030674
GeneOntologyMolecularFunction	chromatin binding	FOXO3 NCOA1 ZNF431 CREBBP EP300 STAT3	5.99e-03	739	45	6	GO:0003682
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ZNF675 FOXO3 ZNF431 KLF8 RFX7 NACC1 EP300 STAT3	6.07e-03	1244	45	8	GO:0000978
GeneOntologyMolecularFunction	transcription coactivator binding	CREBBP EP300	6.60e-03	54	45	2	GO:0001223
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	ZNF675 FOXO3 ZNF431 KLF8 RFX7 NACC1 EP300 STAT3	6.89e-03	1271	45	8	GO:0000987
GeneOntologyMolecularFunction	polyubiquitin modification-dependent protein binding	UBQLN1 UBQLN4	7.83e-03	59	45	2	GO:0031593
GeneOntologyMolecularFunction	transcription coregulator activity	NCOA1 KMT2C WWTR1 CREBBP EP300	8.38e-03	562	45	5	GO:0003712
GeneOntologyMolecularFunction	nuclear receptor binding	NCOA1 EP300 STAT3	8.59e-03	187	45	3	GO:0016922
GeneOntologyBiologicalProcess	regulation of catabolic process	FOXO3 ZSWIM8 PSME3 NRBP2 UBQLN1 SLC11A1 CELF1 EP300 STAT3 UBQLN4 TNRC6A NLRP5	8.15e-06	1252	44	12	GO:0009894
GeneOntologyBiologicalProcess	positive regulation of muscle atrophy	FOXO3 EP300	1.33e-05	3	44	2	GO:0014737
GeneOntologyBiologicalProcess	cellular response to nutrient levels	FOXO3 NCOA1 SZT2 CREBBP EP300 TNRC6A	1.87e-05	262	44	6	GO:0031669
GeneOntologyBiologicalProcess	N-terminal peptidyl-lysine acetylation	CREBBP EP300	2.66e-05	4	44	2	GO:0018076
GeneOntologyBiologicalProcess	regulation of muscle atrophy	FOXO3 EP300	4.43e-05	5	44	2	GO:0014735
GeneOntologyBiologicalProcess	response to carbon dioxide	A2M TRPA1	6.64e-05	6	44	2	GO:0010037
GeneOntologyBiologicalProcess	regulation of miRNA metabolic process	FOXO3 ZSWIM8 EP300 STAT3	6.83e-05	103	44	4	GO:2000628
GeneOntologyBiologicalProcess	positive regulation of hydrogen peroxide-mediated programmed cell death	FOXO3 EP300	9.28e-05	7	44	2	GO:1901300
GeneOntologyBiologicalProcess	negative regulation of autophagy	NRBP2 EP300 STAT3 UBQLN4	9.46e-05	112	44	4	GO:0010507
GeneOntologyBiologicalProcess	miRNA metabolic process	FOXO3 ZSWIM8 EP300 STAT3	1.20e-04	119	44	4	GO:0010586
GeneOntologyBiologicalProcess	post-transcriptional regulation of gene expression	FOXO3 ZSWIM8 ILF3 SLC11A1 CELF1 CELF2 EP300 STAT3 TNRC6A NLRP5	1.24e-04	1153	44	10	GO:0010608
GeneOntologyBiologicalProcess	response to nutrient levels	A2M FOXO3 NCOA1 SZT2 CREBBP EP300 TNRC6A	1.79e-04	566	44	7	GO:0031667
GeneOntologyBiologicalProcess	multicellular organism growth	KMT2C WWTR1 CELF1 EP300 STAT3	1.82e-04	249	44	5	GO:0035264
GeneOntologyBiologicalProcess	mRNA splice site recognition	CELF1 CELF2 MBNL1	1.86e-04	52	44	3	GO:0006376
GeneOntologyBiologicalProcess	regulation of autophagy	FOXO3 NRBP2 UBQLN1 EP300 STAT3 UBQLN4	1.94e-04	400	44	6	GO:0010506
GeneOntologyBiologicalProcess	regulation of alternative mRNA splicing, via spliceosome	CELF1 CELF2 MBNL1	2.71e-04	59	44	3	GO:0000381
GeneOntologyBiologicalProcess	negative regulation of transcription by RNA polymerase II	ZNF675 FOXO3 ZNF431 KLF8 WWTR1 NACC1 CREBBP EP300 STAT3	3.20e-04	1053	44	9	GO:0000122
GeneOntologyBiologicalProcess	cellular response to hypoxia	FOXO3 UBQLN1 EP300 STAT3	4.57e-04	169	44	4	GO:0071456
GeneOntologyBiologicalProcess	muscle atrophy	FOXO3 EP300	4.59e-04	15	44	2	GO:0014889
GeneOntologyBiologicalProcess	positive regulation of miRNA metabolic process	FOXO3 ZSWIM8 STAT3	5.08e-04	73	44	3	GO:2000630
GeneOntologyBiologicalProcess	positive regulation of muscle adaptation	FOXO3 EP300	5.24e-04	16	44	2	GO:0014744
GeneOntologyBiologicalProcess	N-terminal protein amino acid acetylation	CREBBP EP300	5.24e-04	16	44	2	GO:0006474
GeneOntologyBiologicalProcess	regulation of cellular response to heat	CREBBP EP300	5.24e-04	16	44	2	GO:1900034
GeneOntologyBiologicalProcess	cellular response to decreased oxygen levels	FOXO3 UBQLN1 EP300 STAT3	5.56e-04	178	44	4	GO:0036294
GeneOntologyBiologicalProcess	negative regulation of DNA-templated transcription	ZNF675 FOXO3 ZNF431 KLF8 WWTR1 ILF3 NACC1 CREBBP EP300 STAT3	5.90e-04	1399	44	10	GO:0045892
GeneOntologyBiologicalProcess	nucleobase-containing compound catabolic process	ZSWIM8 SLC11A1 CELF1 EP300 STAT3 TNRC6A NLRP5	6.24e-04	696	44	7	GO:0034655
GeneOntologyBiologicalProcess	negative regulation of RNA biosynthetic process	ZNF675 FOXO3 ZNF431 KLF8 WWTR1 ILF3 NACC1 CREBBP EP300 STAT3	6.38e-04	1413	44	10	GO:1902679
GeneOntologyBiologicalProcess	alternative mRNA splicing, via spliceosome	CELF1 CELF2 MBNL1	6.40e-04	79	44	3	GO:0000380
GeneOntologyBiologicalProcess	cellular response to heat	TRPA1 CREBBP EP300	6.88e-04	81	44	3	GO:0034605
GeneOntologyBiologicalProcess	regulation of hydrogen peroxide-mediated programmed cell death	FOXO3 EP300	7.43e-04	19	44	2	GO:1901298
GeneOntologyBiologicalProcess	negative regulation of miRNA-mediated gene silencing	ZSWIM8 STAT3	7.43e-04	19	44	2	GO:0060965
GeneOntologyBiologicalProcess	cellular response to oxygen levels	FOXO3 UBQLN1 EP300 STAT3	7.82e-04	195	44	4	GO:0071453
GeneOntologyBiologicalProcess	negative regulation of post-transcriptional gene silencing	ZSWIM8 STAT3	8.25e-04	20	44	2	GO:0060149
GeneOntologyBiologicalProcess	negative regulation of post-transcriptional gene silencing by regulatory ncRNA	ZSWIM8 STAT3	8.25e-04	20	44	2	GO:1900369
GeneOntologyBiologicalProcess	negative regulation of gene silencing by regulatory ncRNA	ZSWIM8 STAT3	8.25e-04	20	44	2	GO:0060967
GeneOntologyBiologicalProcess	response to hypoxia	FOXO3 UBQLN1 CREBBP EP300 STAT3	8.41e-04	348	44	5	GO:0001666
GeneOntologyBiologicalProcess	rhythmic process	A2M FOXO3 NCOA1 CREBBP EP300	9.78e-04	360	44	5	GO:0048511
GeneOntologyBiologicalProcess	T-helper 17 cell lineage commitment	EP300 STAT3	1.00e-03	22	44	2	GO:0072540
GeneOntologyBiologicalProcess	hydrogen peroxide-mediated programmed cell death	FOXO3 EP300	1.00e-03	22	44	2	GO:0010421
GeneOntologyBiologicalProcess	response to decreased oxygen levels	FOXO3 UBQLN1 CREBBP EP300 STAT3	1.03e-03	364	44	5	GO:0036293
GeneOntologyBiologicalProcess	ovulation cycle	A2M FOXO3 NCOA1	1.09e-03	95	44	3	GO:0042698
GeneOntologyBiologicalProcess	stimulatory C-type lectin receptor signaling pathway	CREBBP EP300	1.09e-03	23	44	2	GO:0002223
GeneOntologyBiologicalProcess	cellular response to lectin	CREBBP EP300	1.09e-03	23	44	2	GO:1990858
GeneOntologyBiologicalProcess	response to lectin	CREBBP EP300	1.09e-03	23	44	2	GO:1990840
GeneOntologyBiologicalProcess	regulation of defense response	A2M UBQLN1 CELF1 NLRP2 CREBBP EP300 STAT3 NLRP5	1.15e-03	1006	44	8	GO:0031347
GeneOntologyBiologicalProcess	programmed cell death in response to reactive oxygen species	FOXO3 EP300	1.19e-03	24	44	2	GO:0097468
GeneOntologyBiologicalProcess	proteasomal protein catabolic process	KIF14 ZSWIM8 WWTR1 PSME3 UBQLN1 UBQLN4	1.22e-03	567	44	6	GO:0010498
GeneOntologyBiologicalProcess	spliceosomal complex assembly	CELF1 CELF2 MBNL1	1.23e-03	99	44	3	GO:0000245
HumanPheno	Aortic isthmus hypoplasia	CREBBP EP300	9.25e-06	2	16	2	HP:0034227
HumanPheno	Plantar crease between first and second toes	CREBBP EP300	9.25e-06	2	16	2	HP:0008107
HumanPheno	High axial triradius	CREBBP EP300	9.25e-06	2	16	2	HP:0001042
HumanPheno	Humoral immunodeficiency	CREBBP EP300	2.77e-05	3	16	2	HP:0005363
HumanPheno	Prominent nasal septum	CREBBP EP300	2.77e-05	3	16	2	HP:0005322
HumanPheno	Radial deviation of thumb terminal phalanx	CREBBP EP300	2.77e-05	3	16	2	HP:0005895
HumanPheno	Laryngeal cartilage malformation	CREBBP EP300	2.77e-05	3	16	2	HP:0008752
HumanPheno	Phobia	CREBBP EP300	2.77e-05	3	16	2	HP:5200232
HumanPheno	Agoraphobia	CREBBP EP300	2.77e-05	3	16	2	HP:0000756
HumanPheno	Trichiasis	CREBBP EP300	5.53e-05	4	16	2	HP:0001128
HumanPheno	Widened distal phalanges	CREBBP EP300	5.53e-05	4	16	2	HP:0006200
HumanPheno	Visceral hemangioma	CREBBP EP300	5.53e-05	4	16	2	HP:0410266
HumanPheno	Talon cusp	CREBBP EP300	5.53e-05	4	16	2	HP:0011087
HumanPheno	Vascular ring	CREBBP EP300	5.53e-05	4	16	2	HP:0010775
HumanPheno	Hepatic hemangioma	CREBBP EP300	5.53e-05	4	16	2	HP:0031207
HumanPheno	Gastroesophageal reflux	KMT2C SLC11A1 CELF2 SZT2 NACC1 CREBBP EP300 STAT3	6.57e-05	517	16	8	HP:0002020
HumanPheno	Papillary cystadenoma of the epididymis	CREBBP EP300	9.20e-05	5	16	2	HP:0009715
HumanPheno	Supernumerary cusp	CREBBP EP300	9.20e-05	5	16	2	HP:0033777
HumanPheno	Epididymal neoplasm	CREBBP EP300	9.20e-05	5	16	2	HP:0030421
HumanPheno	Large foramen magnum	CREBBP EP300	1.38e-04	6	16	2	HP:0002700
HumanPheno	Deviated nasal septum	CREBBP EP300	1.92e-04	7	16	2	HP:0004411
HumanPheno	Natal tooth	KMT2C CREBBP EP300	2.01e-04	38	16	3	HP:0000695
HumanPheno	Pilomatrixoma	CREBBP EP300	3.29e-04	9	16	2	HP:0030434
HumanPheno	Cervical cord compression	CREBBP EP300	3.29e-04	9	16	2	HP:0002341
HumanPheno	Advanced eruption of teeth	KMT2C CREBBP EP300	3.56e-04	46	16	3	HP:0006288
HumanPheno	Frontal hirsutism	CREBBP EP300	4.10e-04	10	16	2	HP:0011335
HumanPheno	Abnormal subclavian artery morphology	CREBBP EP300	5.00e-04	11	16	2	HP:0031251
HumanPheno	Immunologic hypersensitivity	SLC11A1 RFX7 CREBBP EP300 STAT3	5.32e-04	231	16	5	HP:0100326
HumanPheno	Duodenal ulcer	EP300 STAT3	5.99e-04	12	16	2	HP:0002588
HumanPheno	Facial grimacing	CREBBP EP300	7.07e-04	13	16	2	HP:0000273
HumanPheno	Keloids	CREBBP EP300	7.07e-04	13	16	2	HP:0010562
HumanPheno	Parietal foramina	CREBBP EP300	8.23e-04	14	16	2	HP:0002697
HumanPheno	Duplication of phalanx of hallux	CREBBP EP300	8.23e-04	14	16	2	HP:0010066
HumanPheno	Hypoplastic aortic arch	CREBBP EP300	8.23e-04	14	16	2	HP:0012304
HumanPheno	Abnormal stomach morphology	KMT2C SLC11A1 CELF2 SZT2 NACC1 CREBBP EP300 STAT3	8.48e-04	742	16	8	HP:0002577
HumanPheno	Social and occupational deterioration	CREBBP EP300	9.48e-04	15	16	2	HP:0007086
HumanPheno	Duplication of phalanx of toe	CREBBP EP300	9.48e-04	15	16	2	HP:0010181
HumanPheno	Impulsivity	CELF2 SZT2 CREBBP EP300	9.72e-04	149	16	4	HP:0100710
HumanPheno	Square face	CREBBP EP300	1.08e-03	16	16	2	HP:0000321
HumanPheno	Premature thelarche	CREBBP EP300	1.22e-03	17	16	2	HP:0010314
HumanPheno	Motor stereotypy	RFX7 CELF2 NACC1 CREBBP EP300	1.28e-03	280	16	5	HP:0000733
HumanPheno	Facial hirsutism	CREBBP EP300	1.37e-03	18	16	2	HP:0009937
HumanPheno	Skin appendage neoplasm	CREBBP EP300	1.37e-03	18	16	2	HP:0012842
HumanPheno	Asthma	SLC11A1 RFX7 CREBBP EP300	1.39e-03	164	16	4	HP:0002099
Domain	Nuc_rcpt_coact	NCOA1 CREBBP EP300	2.60e-07	6	45	3	IPR009110
Domain	Nuc_rcpt_coact_CREBbp	CREBBP EP300	5.68e-06	2	45	2	IPR014744
Domain	HAT_KAT11	CREBBP EP300	5.68e-06	2	45	2	PF08214
Domain	KIX	CREBBP EP300	5.68e-06	2	45	2	PS50952
Domain	ZnF_TAZ	CREBBP EP300	5.68e-06	2	45	2	SM00551
Domain	CBP_P300_HAT	CREBBP EP300	5.68e-06	2	45	2	IPR031162
Domain	DUF902	CREBBP EP300	5.68e-06	2	45	2	PF06001
Domain	-	CREBBP EP300	5.68e-06	2	45	2	1.20.1020.10
Domain	RING_CBP-p300	CREBBP EP300	5.68e-06	2	45	2	IPR010303
Domain	-	CREBBP EP300	5.68e-06	2	45	2	1.10.1630.10
Domain	Creb_binding	CREBBP EP300	5.68e-06	2	45	2	PF09030
Domain	-	CREBBP EP300	5.68e-06	2	45	2	1.10.246.20
Domain	zf-TAZ	CREBBP EP300	5.68e-06	2	45	2	PF02135
Domain	ZF_TAZ	CREBBP EP300	5.68e-06	2	45	2	PS50134
Domain	Histone_AcTrfase_Rtt109/CBP	CREBBP EP300	5.68e-06	2	45	2	IPR013178
Domain	KAT11	CREBBP EP300	5.68e-06	2	45	2	SM01250
Domain	Znf_TAZ	CREBBP EP300	5.68e-06	2	45	2	IPR000197
Domain	KIX_dom	CREBBP EP300	5.68e-06	2	45	2	IPR003101
Domain	KIX	CREBBP EP300	5.68e-06	2	45	2	PF02172
Domain	CBP_P300_HAT	CREBBP EP300	5.68e-06	2	45	2	PS51727
Domain	UBA-like	UBQLN1 N4BP2 UBQLN4 TNRC6A	1.68e-05	64	45	4	IPR009060
Domain	Ubiquilin	UBQLN1 UBQLN4	8.46e-05	6	45	2	IPR015496
Domain	STI1	UBQLN1 UBQLN4	2.52e-04	10	45	2	SM00727
Domain	STI1_HS-bd	UBQLN1 UBQLN4	2.52e-04	10	45	2	IPR006636
Domain	Hud_Sxl_RNA	CELF1 CELF2	2.52e-04	10	45	2	IPR002343
Domain	ZZ	CREBBP EP300	8.47e-04	18	45	2	PF00569
Domain	ZF_ZZ_2	CREBBP EP300	8.47e-04	18	45	2	PS50135
Domain	ZF_ZZ_1	CREBBP EP300	8.47e-04	18	45	2	PS01357
Domain	Znf_ZZ	CREBBP EP300	9.46e-04	19	45	2	IPR000433
Domain	6-PGluconate_DH_C-like	UBQLN1 UBQLN4	9.46e-04	19	45	2	IPR008927
Domain	ZnF_ZZ	CREBBP EP300	9.46e-04	19	45	2	SM00291
Domain	DAPIN	NLRP2 NLRP5	1.27e-03	22	45	2	PS50824
Domain	PYRIN	NLRP2 NLRP5	1.27e-03	22	45	2	PF02758
Domain	DAPIN	NLRP2 NLRP5	1.27e-03	22	45	2	IPR004020
Domain	PYRIN	NLRP2 NLRP5	1.27e-03	22	45	2	SM01289
Domain	NACHT	NLRP2 NLRP5	1.39e-03	23	45	2	PS50837
Domain	NACHT_NTPase	NLRP2 NLRP5	1.39e-03	23	45	2	IPR007111
Domain	Bromodomain_CS	CREBBP EP300	1.78e-03	26	45	2	IPR018359
Domain	UBA	UBQLN1 UBQLN4	2.37e-03	30	45	2	SM00165
Domain	UBA	UBQLN1 UBQLN4	3.39e-03	36	45	2	PF00627
Domain	BROMODOMAIN_1	CREBBP EP300	3.58e-03	37	45	2	PS00633
Domain	UBIQUITIN_1	UBQLN1 UBQLN4	3.58e-03	37	45	2	PS00299
Domain	Bromodomain	CREBBP EP300	3.78e-03	38	45	2	PF00439
Domain	P-loop_NTPase	KIF14 MDN1 NUBPL ABCA6 NLRP2 N4BP2 NLRP5	3.90e-03	848	45	7	IPR027417
Domain	BROMODOMAIN_2	CREBBP EP300	4.38e-03	41	45	2	PS50014
Domain	BROMO	CREBBP EP300	4.60e-03	42	45	2	SM00297
Domain	Bromodomain	CREBBP EP300	4.60e-03	42	45	2	IPR001487
Domain	-	CREBBP EP300	4.60e-03	42	45	2	1.20.920.10
Domain	UBQ	UBQLN1 UBQLN4	4.81e-03	43	45	2	SM00213
Domain	UBA	UBQLN1 UBQLN4	5.04e-03	44	45	2	IPR015940
Domain	ubiquitin	UBQLN1 UBQLN4	5.73e-03	47	45	2	PF00240
Domain	UBA	UBQLN1 UBQLN4	5.73e-03	47	45	2	PS50030
Pathway	BIOCARTA_PPARG_PATHWAY	NCOA1 CREBBP EP300	9.24e-07	8	37	3	M22058
Pathway	REACTOME_REGULATION_OF_FOXO_TRANSCRIPTIONAL_ACTIVITY_BY_ACETYLATION	FOXO3 CREBBP EP300	1.97e-06	10	37	3	M27945
Pathway	REACTOME_TRANSCRIPTIONAL_REGULATION_BY_RUNX3	FOXO3 WWTR1 PSME3 CREBBP EP300	4.84e-06	96	37	5	M27784
Pathway	WP_IL6_SIGNALING_PATHWAY	FOXO3 NCOA1 CREBBP EP300 STAT3	5.91e-06	100	37	5	MM15826
Pathway	PID_HES_HEY_PATHWAY	NCOA1 CREBBP EP300 STAT3	7.19e-06	48	37	4	M288
Pathway	REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_CELL_DEATH_GENES	FOXO3 CREBBP EP300	9.10e-06	16	37	3	M27940
Pathway	REACTOME_RORA_ACTIVATES_GENE_EXPRESSION	NCOA1 CREBBP EP300	1.32e-05	18	37	3	M26942
Pathway	WP_HEMATOPOIETIC_STEM_CELL_GENE_REGULATION_BY_GABP_ALPHABETA_COMPLEX	FOXO3 CREBBP EP300	2.14e-05	21	37	3	M39593
Pathway	WP_ADIPOGENESIS	NCOA1 WWTR1 CELF1 STAT3 MBNL1	2.20e-05	131	37	5	M39505
Pathway	WP_PATHWAYS_AFFECTED_IN_ADENOID_CYSTIC_CARCINOMA	FOXO3 KMT2C CREBBP EP300	2.42e-05	65	37	4	M39682
Pathway	REACTOME_FOXO_MEDIATED_TRANSCRIPTION	FOXO3 ABCA6 CREBBP EP300	2.58e-05	66	37	4	M27938
Pathway	WP_ADIPOGENESIS_GENES	NCOA1 WWTR1 CELF1 STAT3 MBNL1	2.74e-05	137	37	5	MM15970
Pathway	BIOCARTA_VDR_PATHWAY	NCOA1 CREBBP EP300	3.24e-05	24	37	3	M13404
Pathway	PID_HDAC_CLASSIII_PATHWAY	FOXO3 CREBBP EP300	4.15e-05	26	37	3	M32
Pathway	PID_SMAD2_3NUCLEAR_PATHWAY	FOXO3 NCOA1 CREBBP EP300	6.07e-05	82	37	4	M2
Pathway	PID_RETINOIC_ACID_PATHWAY	NCOA1 CREBBP EP300	6.44e-05	30	37	3	M207
Pathway	BIOCARTA_PELP1_PATHWAY	CREBBP EP300	6.67e-05	5	37	2	MM1575
Pathway	REACTOME_NFE2L2_REGULATING_INFLAMMATION_ASSOCIATED_GENES	CREBBP EP300	6.67e-05	5	37	2	M48020
Pathway	REACTOME_NFE2L2_REGULATING_ER_STRESS_ASSOCIATED_GENES	CREBBP EP300	6.67e-05	5	37	2	M48023
Pathway	REACTOME_LRR_FLII_INTERACTING_PROTEIN_1_LRRFIP1_ACTIVATES_TYPE_I_IFN_PRODUCTION	CREBBP EP300	6.67e-05	5	37	2	M27228
Pathway	WP_ANDROGEN_RECEPTOR_SIGNALING	NCOA1 CREBBP EP300 STAT3	9.12e-05	91	37	4	M39700
Pathway	BIOCARTA_PELP1_PATHWAY	CREBBP EP300	9.99e-05	6	37	2	M22062
Pathway	REACTOME_REGULATION_OF_FOXO_TRANSCRIPTIONAL_ACTIVITY_BY_ACETYLATION	FOXO3 EP300	9.99e-05	6	37	2	MM15660
Pathway	REACTOME_NR1H3_NR1H2_REGULATE_GENE_EXPRESSION_LINKED_TO_CHOLESTEROL_TRANSPORT_AND_EFFLUX	NCOA1 EP300 TNRC6A	1.22e-04	37	37	3	M29790
Pathway	BIOCARTA_PPARG_PATHWAY	CREBBP EP300	1.40e-04	7	37	2	MM1573
Pathway	PID_IFNG_PATHWAY	CREBBP EP300 STAT3	1.54e-04	40	37	3	M161
Pathway	WP_CATABOLISM_OF_SKELETAL_MUSCLE_IN_CACHEXIA	FOXO3 EP300 STAT3	1.54e-04	40	37	3	M48337
Pathway	REACTOME_NFE2L2_REGULATING_MDR_ASSOCIATED_ENZYMES	CREBBP EP300	1.86e-04	8	37	2	M48022
Pathway	REACTOME_REGULATION_OF_NFE2L2_GENE_EXPRESSION	CREBBP EP300	1.86e-04	8	37	2	M48024
Pathway	REACTOME_NFE2L2_REGULATES_PENTOSE_PHOSPHATE_PATHWAY_GENES	CREBBP EP300	1.86e-04	8	37	2	M46443
Pathway	REACTOME_DEVELOPMENTAL_BIOLOGY	FOXO3 NCOA1 KMT2C ZSWIM8 WWTR1 PSME3 CREBBP LIPM EP300 STAT3 TNRC6A SOS2	1.90e-04	1432	37	12	M509
Pathway	WP_IL6_SIGNALING	NCOA1 CREBBP STAT3	1.91e-04	43	37	3	M39656
Pathway	REACTOME_SUMOYLATION_OF_TRANSCRIPTION_COFACTORS	NCOA1 CREBBP EP300	2.05e-04	44	37	3	M27295
Pathway	REACTOME_CELLULAR_RESPONSE_TO_CHEMICAL_STRESS	NCOA1 PSME3 CREBBP EP300 STAT3	2.07e-04	210	37	5	M41836
Pathway	KEGG_MEDICUS_REFERENCE_TLR3_IRF3_SIGNALING_PATHWAY	CREBBP EP300	2.39e-04	9	37	2	M47451
Pathway	REACTOME_NR1H2_AND_NR1H3_MEDIATED_SIGNALING	NCOA1 EP300 TNRC6A	2.49e-04	47	37	3	M29777
Pathway	REACTOME_ESR_MEDIATED_SIGNALING	FOXO3 NCOA1 CREBBP EP300 TNRC6A	2.57e-04	220	37	5	M27794
Pathway	WP_ENERGY_METABOLISM	FOXO3 NCOA1 EP300	2.65e-04	48	37	3	M39590
Pathway	REACTOME_HEME_SIGNALING	NCOA1 CREBBP EP300	2.82e-04	49	37	3	M41832
Pathway	PID_FOXO_PATHWAY	FOXO3 CREBBP EP300	2.82e-04	49	37	3	M136
Pathway	PID_KIT_PATHWAY	FOXO3 CREBBP STAT3	3.37e-04	52	37	3	M231
Pathway	BIOCARTA_PPARA_PATHWAY	NCOA1 CREBBP EP300	3.37e-04	52	37	3	M2404
Pathway	PID_AR_TF_PATHWAY	NCOA1 CREBBP EP300	3.56e-04	53	37	3	M151
Pathway	WP_TGFBETA_SIGNALING_PATHWAY	CREBBP EP300 STAT3	3.56e-04	53	37	3	MM15880
Pathway	REACTOME_TRANSCRIPTIONAL_REGULATION_BY_RUNX1	KMT2C PSME3 CREBBP EP300 TNRC6A	3.62e-04	237	37	5	M27786
Pathway	BIOCARTA_CARM1_PATHWAY	CREBBP EP300	3.63e-04	11	37	2	MM1521
Pathway	REACTOME_NFE2L2_REGULATING_TUMORIGENIC_GENES	CREBBP EP300	3.63e-04	11	37	2	M48021
Pathway	REACTOME_STAT3_NUCLEAR_EVENTS_DOWNSTREAM_OF_ALK_SIGNALING	EP300 STAT3	3.63e-04	11	37	2	M42523
Pathway	REACTOME_INTERLEUKIN_15_SIGNALING	STAT3 SOS2	3.63e-04	11	37	2	MM15578
Pathway	REACTOME_REGULATION_OF_GENE_EXPRESSION_BY_HYPOXIA_INDUCIBLE_FACTOR	CREBBP EP300	3.63e-04	11	37	2	M26924
Pathway	WP_TGFBETA_RECEPTOR_SIGNALING	CREBBP EP300 STAT3	3.98e-04	55	37	3	M39351
Pathway	BIOCARTA_CARM1_PATHWAY	CREBBP EP300	4.35e-04	12	37	2	M7968
Pathway	REACTOME_ACTIVATION_OF_THE_TFAP2_AP_2_FAMILY_OF_TRANSCRIPTION_FACTORS	CREBBP EP300	4.35e-04	12	37	2	M27765
Pathway	WP_KIT_RECEPTOR_SIGNALING	FOXO3 EP300 STAT3	4.89e-04	59	37	3	M39350
Pathway	WP_TGFBETA_RECEPTOR_SIGNALING_IN_SKELETAL_DYSPLASIAS	CREBBP EP300 STAT3	4.89e-04	59	37	3	M39886
Pathway	REACTOME_NR1H2_AND_NR1H3_MEDIATED_SIGNALING	NCOA1 EP300	5.13e-04	13	37	2	MM15622
Pathway	REACTOME_CYTOPROTECTION_BY_HMOX1	NCOA1 CREBBP STAT3	5.14e-04	60	37	3	M41830
Pathway	PID_MYC_REPRESS_PATHWAY	FOXO3 SLC11A1 EP300	5.93e-04	63	37	3	M254
Pathway	REACTOME_RUNX3_REGULATES_NOTCH_SIGNALING	CREBBP EP300	5.98e-04	14	37	2	M27808
Pathway	REACTOME_INTERLEUKIN_15_SIGNALING	STAT3 SOS2	5.98e-04	14	37	2	M27858
Pathway	REACTOME_ESTROGEN_DEPENDENT_GENE_EXPRESSION	NCOA1 CREBBP EP300 TNRC6A	6.04e-04	149	37	4	M27888
Pathway	WP_HEPATITIS_B_INFECTION	CREBBP EP300 STAT3 SOS2	6.35e-04	151	37	4	M39801
Pathway	PID_HIF1_TFPATHWAY	NCOA1 CREBBP EP300	6.80e-04	66	37	3	M255
Pathway	PID_HDAC_CLASSI_PATHWAY	CREBBP EP300 STAT3	6.80e-04	66	37	3	M101
Pathway	BIOCARTA_RELA_PATHWAY	CREBBP EP300	6.89e-04	15	37	2	MM1339
Pathway	BIOCARTA_RELA_PATHWAY	CREBBP EP300	6.89e-04	15	37	2	M10183
Pathway	BIOCARTA_PITX2_PATHWAY	CREBBP EP300	6.89e-04	15	37	2	MM1439
Pathway	REACTOME_TRAF3_DEPENDENT_IRF_ACTIVATION_PATHWAY	CREBBP EP300	6.89e-04	15	37	2	M953
Pathway	KEGG_JAK_STAT_SIGNALING_PATHWAY	CREBBP EP300 STAT3 SOS2	7.00e-04	155	37	4	M17411
Pathway	WP_UROTENSINIIMEDIATED_SIGNALING	CREBBP EP300 STAT3	7.74e-04	69	37	3	M48052
Pathway	REACTOME_FORMATION_OF_PARAXIAL_MESODERM	PSME3 CREBBP EP300	7.74e-04	69	37	3	M46439
Pathway	REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_LATE_STAGE_BRANCHING_MORPHOGENESIS_PANCREATIC_BUD_PRECURSOR_CELLS	CREBBP EP300	7.86e-04	16	37	2	M27121
Pathway	BIOCARTA_IL7_PATHWAY	CREBBP EP300	7.86e-04	16	37	2	M1296
Pathway	BIOCARTA_IL7_PATHWAY	CREBBP EP300	7.86e-04	16	37	2	MM1420
Pathway	BIOCARTA_PITX2_PATHWAY	CREBBP EP300	7.86e-04	16	37	2	M8516
Pathway	KEGG_RENAL_CELL_CARCINOMA	CREBBP EP300 SOS2	8.07e-04	70	37	3	M13266
Pathway	REACTOME_CIRCADIAN_CLOCK	NCOA1 CREBBP EP300	8.07e-04	70	37	3	M938
Pathway	WP_NONSMALL_CELL_LUNG_CANCER	FOXO3 STAT3 SOS2	8.76e-04	72	37	3	M39738
Pathway	BIOCARTA_TGFB_PATHWAY	CREBBP EP300	8.89e-04	17	37	2	MM1509
Pathway	REACTOME_ZYGOTIC_GENOME_ACTIVATION_ZGA	CREBBP EP300	8.89e-04	17	37	2	M48025
Pathway	REACTOME_SIGNALING_BY_ALK	EP300 STAT3	8.89e-04	17	37	2	MM14790
Pathway	REACTOME_CELLULAR_RESPONSE_TO_HYPOXIA	PSME3 CREBBP EP300	9.87e-04	75	37	3	M641
Pathway	REACTOME_SIGNALING_BY_NUCLEAR_RECEPTORS	FOXO3 NCOA1 CREBBP EP300 TNRC6A	9.91e-04	296	37	5	M27869
Pathway	WP_MECHANISMS_ASSOCIATED_WITH_PLURIPOTENCY	NCOA1 NACC1 CREBBP EP300 STAT3	1.07e-03	301	37	5	MM15983
Pathway	BIOCARTA_TGFB_PATHWAY	CREBBP EP300	1.11e-03	19	37	2	M18933
Pathway	REACTOME_NFE2L2_REGULATING_ANTI_OXIDANT_DETOXIFICATION_ENZYMES	CREBBP EP300	1.11e-03	19	37	2	M46442
Pathway	REACTOME_NOTCH4_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION	CREBBP EP300	1.24e-03	20	37	2	M27881
Pathway	REACTOME_SIGNALING_BY_NOTCH4	PSME3 CREBBP EP300	1.28e-03	82	37	3	M594
Pathway	PID_REG_GR_PATHWAY	NCOA1 CREBBP EP300	1.28e-03	82	37	3	M115
Pathway	REACTOME_CD209_DC_SIGN_SIGNALING	CREBBP EP300	1.36e-03	21	37	2	M27485
Pathway	REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION	NCOA1 CREBBP EP300	1.37e-03	84	37	3	M1008
Pathway	WP_EGFR_TYROSINE_KINASE_INHIBITOR_RESISTANCE	FOXO3 STAT3 SOS2	1.37e-03	84	37	3	M39839
Pathway	WP_CLEAR_CELL_RENAL_CELL_CARCINOMA_PATHWAYS	CREBBP EP300 STAT3	1.47e-03	86	37	3	M39375
Pathway	BIOCARTA_VDR_PATHWAY	CREBBP EP300	1.50e-03	22	37	2	MM1370
Pathway	BIOCARTA_NTHI_PATHWAY	CREBBP EP300	1.50e-03	22	37	2	MM1443
Pathway	REACTOME_FOXO_MEDIATED_TRANSCRIPTION	FOXO3 EP300	1.50e-03	22	37	2	MM15656
Pathway	KEGG_PROSTATE_CANCER	CREBBP EP300 SOS2	1.62e-03	89	37	3	M13191
Pathway	BIOCARTA_NTHI_PATHWAY	CREBBP EP300	1.64e-03	23	37	2	M2821
Pathway	BIOCARTA_HER2_PATHWAY	EP300 STAT3	1.64e-03	23	37	2	MM1480
Pathway	BIOCARTA_HER2_PATHWAY	EP300 STAT3	1.64e-03	23	37	2	M18719
Pubmed	Activation of Stat3 sequence-specific DNA binding and transcription by p300/CREB-binding protein-mediated acetylation.	CREBBP EP300 STAT3	2.02e-09	3	45	3	15649887
Pubmed	Structures of KIX domain of CBP in complex with two FOXO3a transactivation domains reveal promiscuity and plasticity in coactivator recruitment.	FOXO3 CREBBP EP300	2.02e-09	3	45	3	22474372
Pubmed	Functional interaction of STAT3 transcription factor with the coactivator NcoA/SRC1a.	NCOA1 EP300 STAT3	2.02e-09	3	45	3	11773079
Pubmed	Co-activator SRC-1 is dispensable for transcriptional control by STAT3.	NCOA1 EP300 STAT3	2.02e-09	3	45	3	19203349
Pubmed	Human immunodeficiency virus type 1 (HIV-1) accessory protein Vpr induces transcription of the HIV-1 and glucocorticoid-responsive promoters by binding directly to p300/CBP coactivators.	NCOA1 CREBBP EP300	8.09e-09	4	45	3	12208951
Pubmed	The oncoprotein Tax binds the SRC-1-interacting domain of CBP/p300 to mediate transcriptional activation.	NCOA1 CREBBP EP300	8.09e-09	4	45	3	11463834
Pubmed	KLF8 recruits the p300 and PCAF co-activators to its amino terminal activation domain to activate transcription.	KLF8 CREBBP EP300	8.09e-09	4	45	3	20107328
Pubmed	Analysis of the steroid receptor coactivator 1 (SRC1)-CREB binding protein interaction interface and its importance for the function of SRC1.	NCOA1 CREBBP EP300	8.09e-09	4	45	3	11113179
Pubmed	MLL3/MLL4 are required for CBP/p300 binding on enhancers and super-enhancer formation in brown adipogenesis.	KMT2C CREBBP EP300	8.09e-09	4	45	3	28398509
Pubmed	Identification and characterization of BCL-3-binding protein: implications for transcription and DNA repair or recombination.	CREBBP N4BP2 EP300	8.09e-09	4	45	3	12730195
Pubmed	Stat protein transactivation domains recruit p300/CBP through widely divergent sequences.	CREBBP EP300 STAT3	2.02e-08	5	45	3	10464260
Pubmed	Dynamic balance between activation and repression regulates pre-mRNA alternative splicing during heart development.	CELF1 CELF2 MBNL1	2.02e-08	5	45	3	15830352
Pubmed	A Conserved alpha-helical motif mediates the binding of diverse nuclear proteins to the SRC1 interaction domain of CBP.	NCOA1 CREBBP EP300	2.02e-08	5	45	3	14722092
Pubmed	Neurogenin promotes neurogenesis and inhibits glial differentiation by independent mechanisms.	CREBBP EP300 STAT3	2.02e-08	5	45	3	11239394
Pubmed	Angiotensinogen gene expression is dependent on signal transducer and activator of transcription 3-mediated p300/cAMP response element binding protein-binding protein coactivator recruitment and histone acetyltransferase activity.	CREBBP EP300 STAT3	2.02e-08	5	45	3	11923478
Pubmed	Temporal/spatial expression of nuclear receptor coactivators in the mouse lung.	NCOA1 CREBBP EP300	4.04e-08	6	45	3	11076796
Pubmed	MBNL and CELF proteins regulate alternative splicing of the skeletal muscle chloride channel CLCN1.	CELF1 CELF2 MBNL1	4.04e-08	6	45	3	19720736
Pubmed	Bcl3, an IkappaB protein, stimulates activating protein-1 transactivation and cellular proliferation.	NCOA1 CREBBP EP300	4.04e-08	6	45	3	10497212
Pubmed	Role of CBP in regulating HIF-1-mediated activation of transcription.	NCOA1 CREBBP EP300	4.04e-08	6	45	3	15615775
Pubmed	DAF-16 recruits the CREB-binding protein coactivator complex to the insulin-like growth factor binding protein 1 promoter in HepG2 cells.	NCOA1 CREBBP EP300	4.04e-08	6	45	3	10973497
Pubmed	Stat3 dimerization regulated by reversible acetylation of a single lysine residue.	CREBBP EP300 STAT3	4.04e-08	6	45	3	15653507
Pubmed	A WW domain protein TAZ is a critical coactivator for TBX5, a transcription factor implicated in Holt-Oram syndrome.	WWTR1 CREBBP EP300	7.06e-08	7	45	3	16332960
Pubmed	Chromatin remodelling by the glucocorticoid receptor requires the BRG1 complex.	NCOA1 CREBBP EP300	7.06e-08	7	45	3	9590696
Pubmed	HIF-1alpha, STAT3, CBP/p300 and Ref-1/APE are components of a transcriptional complex that regulates Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas.	CREBBP EP300 STAT3	7.06e-08	7	45	3	15735682
Pubmed	Acetylation-dependent signal transduction for type I interferon receptor.	CREBBP EP300 STAT3	1.13e-07	8	45	3	17923090
Pubmed	Aberrant association of promyelocytic leukemia protein-retinoic acid receptor-alpha with coactivators contributes to its ability to regulate gene expression.	NCOA1 CREBBP EP300	1.13e-07	8	45	3	17475621
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	NCOA1 KMT2C PSME3 ILF3 UBQLN1 CELF1 CELF2 NACC1 CREBBP EP300 MBNL1	1.17e-07	1103	45	11	34189442
Pubmed	Nanog binds to Smad1 and blocks bone morphogenetic protein-induced differentiation of embryonic stem cells.	CREBBP EP300 STAT3	1.69e-07	9	45	3	16801560
Pubmed	Human transcription factor protein interaction networks.	NCOA1 KMT2C KLF8 PSME3 RFX7 NACC1 CREBBP EP300 STAT3 MBNL1 MRPL2 TNRC6A	1.80e-07	1429	45	12	35140242
Pubmed	Natural helix 9 mutants of PPARγ differently affect its transcriptional activity.	NCOA1 CREBBP EP300	2.41e-07	10	45	3	30595551
Pubmed	Activating signal cointegrator 1, a novel transcription coactivator of nuclear receptors, and its cytosolic localization under conditions of serum deprivation.	NCOA1 CREBBP EP300	3.32e-07	11	45	3	10454579
Pubmed	Corepressors selectively control the transcriptional activity of PPARgamma in adipocytes.	NCOA1 CREBBP EP300	3.32e-07	11	45	3	15681609
Pubmed	Identification of a transcriptionally active peroxisome proliferator-activated receptor alpha -interacting cofactor complex in rat liver and characterization of PRIC285 as a coactivator.	NCOA1 CREBBP EP300	4.42e-07	12	45	3	12189208
Pubmed	Extensive alternative splicing transitions during postnatal skeletal muscle development are required for calcium handling functions.	CELF1 CELF2 MBNL1	7.29e-07	14	45	3	28826478
Pubmed	MED25 is distinct from TRAP220/MED1 in cooperating with CBP for retinoid receptor activation.	NCOA1 CREBBP EP300	7.29e-07	14	45	3	17641689
Pubmed	Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins.	NCOA1 KMT2C CREBBP	7.29e-07	14	45	3	12482968
Pubmed	New nomenclature for chromatin-modifying enzymes.	NCOA1 KMT2C CREBBP EP300	9.19e-07	57	45	4	18022353
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	FOXO3 KIF14 WWTR1 MDN1 RFX7 DENND1A N4BP2 STAT3 RALGAPB	1.34e-06	861	45	9	36931259
Pubmed	Screening and association testing of common coding variation in steroid hormone receptor co-activator and co-repressor genes in relation to breast cancer risk: the Multiethnic Cohort.	NCOA1 CREBBP EP300	1.36e-06	17	45	3	19183483
Pubmed	The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation.	NCOA1 RFX7 CREBBP EP300 TNRC6A	1.58e-06	152	45	5	38360978
Pubmed	Loss of p300 accelerates MDS-associated leukemogenesis.	CREBBP EP300	1.64e-06	2	45	2	27881875
Pubmed	Molecular characterization of the histone acetyltransferase CREBBP/EP300 genes in myeloid neoplasia.	CREBBP EP300	1.64e-06	2	45	2	34845315
Pubmed	p300 plays a critical role in maintaining cardiac mitochondrial function and cell survival in postnatal hearts.	CREBBP EP300	1.64e-06	2	45	2	19729597
Pubmed	CREB-binding protein/P300 bromodomain inhibition reduces neutrophil accumulation and activates antitumor immunity in triple-negative breast cancer.	CREBBP EP300	1.64e-06	2	45	2	39287984
Pubmed	Exon deletions of the EP300 and CREBBP genes in two children with Rubinstein-Taybi syndrome detected by aCGH.	CREBBP EP300	1.64e-06	2	45	2	20717166
Pubmed	The epigenetic regulators CBP and p300 facilitate leukemogenesis and represent therapeutic targets in acute myeloid leukemia.	CREBBP EP300	1.64e-06	2	45	2	25893291
Pubmed	Human T-lymphotropic virus type 1 p30(II) regulates gene transcription by binding CREB binding protein/p300.	CREBBP EP300	1.64e-06	2	45	2	11559821
Pubmed	CARM1 inhibition reduces histone acetyltransferase activity causing synthetic lethality in CREBBP/EP300-mutated lymphomas.	CREBBP EP300	1.64e-06	2	45	2	32576962
Pubmed	Syndromic features and mild cognitive impairment in mice with genetic reduction on p300 activity: Differential contribution of p300 and CBP to Rubinstein-Taybi syndrome etiology.	CREBBP EP300	1.64e-06	2	45	2	19822209
Pubmed	A specific CBP/p300-dependent gene expression programme drives the metabolic remodelling in late stages of spermatogenesis.	CREBBP EP300	1.64e-06	2	45	2	24522976
Pubmed	CBP is required for environmental enrichment-induced neurogenesis and cognitive enhancement.	CREBBP EP300	1.64e-06	2	45	2	21847097
Pubmed	CUGBP1 and MBNL1 preferentially bind to 3' UTRs and facilitate mRNA decay.	CELF1 MBNL1	1.64e-06	2	45	2	22355723
Pubmed	p300 or CBP is required for insulin-stimulated glucose uptake in skeletal muscle and adipocytes.	CREBBP EP300	1.64e-06	2	45	2	34813504
Pubmed	Rubinstein-Taybi Syndrome	CREBBP EP300	1.64e-06	2	45	2	20301699
Pubmed	Isolation and expression of Napor/CUG-BP2 in embryo development.	CELF1 CELF2	1.64e-06	2	45	2	12763013
Pubmed	Potential biomarker of metformin action.	CREBBP EP300	1.64e-06	2	45	2	24639469
Pubmed	The histone acetyl transferases CBP and p300 regulate stress response pathways in synovial fibroblasts at transcriptional and functional levels.	CREBBP EP300	1.64e-06	2	45	2	37816914
Pubmed	Expression of a dominant negative CELF protein in vivo leads to altered muscle organization, fiber size, and subtype.	CELF1 CELF2	1.64e-06	2	45	2	21541285
Pubmed	Binding of p300/CBP co-activators by polyoma large T antigen.	CREBBP EP300	1.64e-06	2	45	2	11438528
Pubmed	Smad-dependent stimulation of type I collagen gene expression in human skin fibroblasts by TGF-beta involves functional cooperation with p300/CBP transcriptional coactivators.	CREBBP EP300	1.64e-06	2	45	2	10918613
Pubmed	Histone Acetyltransferases p300 and CBP Coordinate Distinct Chromatin Remodeling Programs in Vascular Smooth Muscle Plasticity.	CREBBP EP300	1.64e-06	2	45	2	35502657
Pubmed	p300 and cAMP response element-binding protein-binding protein in skeletal muscle homeostasis, contractile function, and survival.	CREBBP EP300	1.64e-06	2	45	2	31898871
Pubmed	Germline or inducible knockout of p300 or CBP in skeletal muscle does not alter insulin sensitivity.	CREBBP EP300	1.64e-06	2	45	2	30888860
Pubmed	Exploitation of EP300 and CREBBP Lysine Acetyltransferases by Cancer.	CREBBP EP300	1.64e-06	2	45	2	27881443
Pubmed	Spatiotemporal expression of histone acetyltransferases, p300 and CBP, in developing embryonic hearts.	CREBBP EP300	1.64e-06	2	45	2	19272189
Pubmed	Differential contribution of p300 and CBP to regulatory element acetylation in mESCs.	CREBBP EP300	1.64e-06	2	45	2	32690000
Pubmed	CBP/p300 antagonises EGFR-Ras-Erk signalling and suppresses increased Ras-Erk signalling-induced tumour formation in mice.	CREBBP EP300	1.64e-06	2	45	2	30953353
Pubmed	Disrupting the CH1 domain structure in the acetyltransferases CBP and p300 results in lean mice with increased metabolic control.	CREBBP EP300	1.64e-06	2	45	2	21803292
Pubmed	HIV-1 tat transactivator recruits p300 and CREB-binding protein histone acetyltransferases to the viral promoter.	CREBBP EP300	1.64e-06	2	45	2	9811832
Pubmed	Two independent regions of simian virus 40 T antigen increase CBP/p300 levels, alter patterns of cellular histone acetylation, and immortalize primary cells.	CREBBP EP300	1.64e-06	2	45	2	24089570
Pubmed	Genetic heterogeneity in Rubinstein-Taybi syndrome: mutations in both the CBP and EP300 genes cause disease.	CREBBP EP300	1.64e-06	2	45	2	15706485
Pubmed	AR coactivators, CBP/p300, are critical mediators of DNA repair in prostate cancer.	CREBBP EP300	1.64e-06	2	45	2	39266679
Pubmed	A boy with classical Rubinstein-Taybi syndrome but no detectable mutation in the CREBBP and EP300 genes.	CREBBP EP300	1.64e-06	2	45	2	22303793
Pubmed	Inhibition of histone acetyltransferase function radiosensitizes CREBBP/EP300 mutants via repression of homologous recombination, potentially targeting a gain of function.	CREBBP EP300	1.64e-06	2	45	2	34732714
Pubmed	Targeting histone acetylation dynamics and oncogenic transcription by catalytic P300/CBP inhibition.	CREBBP EP300	1.64e-06	2	45	2	34019788
Pubmed	STAT3 nuclear import is independent of tyrosine phosphorylation and mediated by importin-alpha3.	EP300 STAT3	1.64e-06	2	45	2	15919823
Pubmed	MBNL1 is the primary determinant of focus formation and aberrant insulin receptor splicing in DM1.	CELF1 MBNL1	1.64e-06	2	45	2	15546872
Pubmed	Diversity and conservation of CELF1 and CELF2 RNA and protein expression patterns during embryonic development.	CELF1 CELF2	1.64e-06	2	45	2	23468433
Pubmed	Endogenous CCAAT/enhancer binding protein beta and p300 are both regulated by growth hormone to mediate transcriptional activation.	CREBBP EP300	1.64e-06	2	45	2	15860545
Pubmed	Biochanin A enhances RORγ activity through STAT3-mediated recruitment of NCOA1.	NCOA1 STAT3	1.64e-06	2	45	2	28579428
Pubmed	Further delineation of an entity caused by CREBBP and EP300 mutations but not resembling Rubinstein-Taybi syndrome.	CREBBP EP300	1.64e-06	2	45	2	29460469
Pubmed	Expression of p300 and CBP is associated with poor prognosis in small cell lung cancer.	CREBBP EP300	1.64e-06	2	45	2	24551300
Pubmed	Genome-wide CRISPR screens reveal synthetic lethal interaction between CREBBP and EP300 in diffuse large B-cell lymphoma.	CREBBP EP300	1.64e-06	2	45	2	33911074
Pubmed	The adenovirus 12 E1A proteins can bind directly to proteins of the p300 transcription co-activator family, including the CREB-binding protein CBP and p300.	CREBBP EP300	1.64e-06	2	45	2	9018065
Pubmed	Coactivators p300 and CBP maintain the identity of mouse embryonic stem cells by mediating long-range chromatin structure.	CREBBP EP300	1.64e-06	2	45	2	24648406
Pubmed	CBP and P300 regulate distinct gene networks required for human primary myoblast differentiation and muscle integrity.	CREBBP EP300	1.64e-06	2	45	2	30135524
Pubmed	Distribution of co-activators CBP and p300 during mouse oocyte and embryo development.	CREBBP EP300	1.64e-06	2	45	2	16596650
Pubmed	The p300 and CBP Transcriptional Coactivators Are Required for β-Cell and α-Cell Proliferation.	CREBBP EP300	1.64e-06	2	45	2	29217654
Pubmed	Differences in the interactions of oncogenic adenovirus 12 early region 1A and nononcogenic adenovirus 2 early region 1A with the cellular coactivators p300 and CBP.	CREBBP EP300	1.64e-06	2	45	2	10049825
Pubmed	CBP/p300 acetyltransferase activity in hematologic malignancies.	CREBBP EP300	1.64e-06	2	45	2	27380996
Pubmed	CREBBP and p300 lysine acetyl transferases in the DNA damage response.	CREBBP EP300	1.64e-06	2	45	2	29170789
Pubmed	Crebbp haploinsufficiency in mice alters the bone marrow microenvironment, leading to loss of stem cells and excessive myelopoiesis.	CREBBP EP300	1.64e-06	2	45	2	21555743
Pubmed	CBP/p300 induction is required for retinoic acid sensitivity in human mammary cells.	CREBBP EP300	1.64e-06	2	45	2	12646247
Pubmed	Histone acetyltransferase activities of cAMP-regulated enhancer-binding protein and p300 in tissues of fetal, young, and old mice.	CREBBP EP300	1.64e-06	2	45	2	11867645
Pubmed	Expression of the nuclear coactivators CBP and p300 in developing craniofacial tissue.	CREBBP EP300	1.64e-06	2	45	2	11963968
Pubmed	Region 752-761 of STAT3 is critical for SRC-1 recruitment and Ser727 phosphorylation.	NCOA1 STAT3	1.64e-06	2	45	2	15530426
Pubmed	Differential transcriptional activation by human T-cell leukemia virus type 1 Tax mutants is mediated by distinct interactions with CREB binding protein and p300.	CREBBP EP300	1.64e-06	2	45	2	9528808
Pubmed	Analysis of genetic stability at the EP300 and CREBBP loci in a panel of cancer cell lines.	CREBBP EP300	1.64e-06	2	45	2	12696060
Pubmed	Inhibition of ROS and upregulation of inflammatory cytokines by FoxO3a promotes survival against Salmonella typhimurium.	FOXO3 SLC11A1	1.64e-06	2	45	2	27599659
Pubmed	CBP Is Required for Establishing Adaptive Gene Programs in the Adult Mouse Brain.	CREBBP EP300	1.64e-06	2	45	2	36109165
Interaction	DAZL interactions	ZSWIM8 ILF3 CELF1 CELF2 N4BP2 MBNL1 TNRC6A	3.12e-08	145	45	7	int:DAZL
Interaction	BCL3 interactions	NCOA1 CREBBP N4BP2 EP300 STAT3	1.55e-07	56	45	5	int:BCL3
Interaction	RUNX2 interactions	NCOA1 WWTR1 PSME3 CREBBP EP300 STAT3	3.53e-07	126	45	6	int:RUNX2
Interaction	CREBBP interactions	FOXO3 NCOA1 KLF8 WWTR1 PSME3 CREBBP N4BP2 EP300 STAT3 SOS2	6.23e-07	599	45	10	int:CREBBP
Interaction	NCOA6 interactions	NCOA1 KMT2C WWTR1 CREBBP EP300 TNRC6A	8.08e-07	145	45	6	int:NCOA6
Interaction	HNF1A interactions	NCOA1 KMT2C CREBBP EP300 STAT3	9.37e-07	80	45	5	int:HNF1A
Interaction	TFF1 interactions	UBQLN1 CREBBP EP300 UBQLN4	2.07e-06	41	45	4	int:TFF1
Interaction	PRRC2A interactions	KIF14 KLF8 WWTR1 UBQLN1 CELF1 CELF2 UBQLN4 TNRC6A	2.07e-06	389	45	8	int:PRRC2A
Interaction	PRRC2C interactions	KIF14 KLF8 WWTR1 ILF3 UBQLN1 CELF1 UBQLN4	3.38e-06	290	45	7	int:PRRC2C
Interaction	KLF2 interactions	PSME3 CREBBP EP300	4.65e-06	15	45	3	int:KLF2
Interaction	SMG7 interactions	NCOA1 ZSWIM8 WWTR1 CELF1 NACC1 CREBBP TNRC6A	6.31e-06	319	45	7	int:SMG7
Interaction	AGO2 interactions	A2M KIF14 ZSWIM8 WWTR1 ILF3 CELF1 MBNL1 TNRC6A	8.59e-06	472	45	8	int:AGO2
Interaction	RAD23A interactions	A2M UBQLN1 SZT2 CREBBP EP300 UBQLN4	1.00e-05	224	45	6	int:RAD23A
Interaction	SLC5A10 interactions	UBQLN1 UBQLN4	1.46e-05	3	45	2	int:SLC5A10
Interaction	DYNLL1 interactions	KIF14 KMT2C WWTR1 PSME3 ILF3 UBQLN1 N4BP2 UBQLN4	1.51e-05	510	45	8	int:DYNLL1
Interaction	NCOA2 interactions	NCOA1 KLF8 WWTR1 CREBBP EP300	1.52e-05	141	45	5	int:NCOA2
Interaction	CDKN1A interactions	A2M FOXO3 ZNF431 PSME3 CREBBP EP300 STAT3	1.80e-05	375	45	7	int:CDKN1A
Interaction	NR6A1 interactions	NCOA1 CREBBP EP300	2.04e-05	24	45	3	int:NR6A1
Interaction	TP53BP1 interactions	WWTR1 PSME3 ILF3 MDN1 CREBBP EP300 MBNL1 TNRC6A	2.07e-05	533	45	8	int:TP53BP1
Interaction	TLE6 interactions	KIF14 WWTR1 EP300	2.31e-05	25	45	3	int:TLE6
Interaction	TRIM24 interactions	NCOA1 KLF8 ILF3 CREBBP EP300 STAT3 TNRC6A	2.64e-05	398	45	7	int:TRIM24
Interaction	H2BC3 interactions	KMT2C UBQLN1 MDN1 CELF1 CREBBP EP300 UBQLN4	3.00e-05	406	45	7	int:H2BC3
Interaction	ARID1A interactions	FOXO3 NCOA1 WWTR1 CREBBP EP300 TNRC6A	3.25e-05	276	45	6	int:ARID1A
Interaction	ZFPM2 interactions	EP300 STAT3 UBQLN4	3.28e-05	28	45	3	int:ZFPM2
Interaction	SOX7 interactions	NCOA1 KMT2C CREBBP EP300	3.34e-05	82	45	4	int:SOX7
Interaction	RXRA interactions	NCOA1 CREBBP EP300 STAT3 UBQLN4	3.64e-05	169	45	5	int:RXRA
Interaction	KMT2D interactions	KMT2C KLF8 WWTR1 CREBBP EP300	3.64e-05	169	45	5	int:KMT2D
Interaction	TNRC6B interactions	KIF14 WWTR1 CELF1 N4BP2 UBQLN4 TNRC6A	3.67e-05	282	45	6	int:TNRC6B
Interaction	UFD1 interactions	A2M UBQLN1 NUBPL EP300 UBQLN4	3.74e-05	170	45	5	int:UFD1
Interaction	NUP35 interactions	KMT2C WWTR1 ILF3 CREBBP EP300 MBNL1 TNRC6A	3.95e-05	424	45	7	int:NUP35
Interaction	EP300 interactions	FOXO3 NCOA1 KIF14 KLF8 WWTR1 PSME3 ILF3 UBQLN1 CREBBP N4BP2 EP300 STAT3	4.06e-05	1401	45	12	int:EP300
Interaction	STAT6 interactions	NCOA1 CREBBP EP300 STAT3	4.22e-05	87	45	4	int:STAT6
Interaction	PPP1R13L interactions	KIF14 CREBBP EP300 MBNL1	4.41e-05	88	45	4	int:PPP1R13L
Interaction	TEAD1 interactions	NCOA1 KMT2C WWTR1 CREBBP EP300	4.42e-05	176	45	5	int:TEAD1
Interaction	FUBP3 interactions	KIF14 CELF1 CELF2 EP300 TNRC6A SOS2	4.89e-05	297	45	6	int:FUBP3
Interaction	PSMD8 interactions	KLF8 PSME3 UBQLN1 EP300 UBQLN4	5.18e-05	182	45	5	int:PSMD8
Interaction	STAT3 interactions	A2M NCOA1 WWTR1 CREBBP EP300 STAT3 MBNL1	5.44e-05	446	45	7	int:STAT3
Interaction	TP63 interactions	A2M KLF8 WWTR1 N4BP2 EP300 RALGAPB	5.57e-05	304	45	6	int:TP63
Interaction	SP7 interactions	NCOA1 KMT2C NACC1 CREBBP EP300 MBNL1	5.57e-05	304	45	6	int:SP7
Interaction	PPARG interactions	NCOA1 KMT2C WWTR1 ILF3 CREBBP EP300	5.88e-05	307	45	6	int:PPARG
Interaction	RIC8A interactions	KIF14 UBQLN1 EP300 UBQLN4	6.20e-05	96	45	4	int:RIC8A
Interaction	YTHDF2 interactions	KIF14 KLF8 NRBP2 CELF1 CREBBP TNRC6A	6.43e-05	312	45	6	int:YTHDF2
Interaction	SMARCA4 interactions	NCOA1 KIF14 WWTR1 PSME3 CREBBP EP300 STAT3	6.79e-05	462	45	7	int:SMARCA4
Interaction	CEBPA interactions	NCOA1 KMT2C PSME3 ILF3 UBQLN1 CELF1 CELF2 NACC1 CREBBP EP300 MBNL1	6.92e-05	1245	45	11	int:CEBPA
Interaction	MYOD1 interactions	NCOA1 KMT2C CREBBP EP300 STAT3	7.02e-05	194	45	5	int:MYOD1
Interaction	SF3B6 interactions	KIF14 PSME3 ILF3 EP300 SOS2	7.02e-05	194	45	5	int:SF3B6
Interaction	HOXB2 interactions	NCOA1 CREBBP EP300	7.05e-05	36	45	3	int:HOXB2
Interaction	LARP1 interactions	KIF14 KLF8 WWTR1 ILF3 NLRP2 DENND1A EP300	7.07e-05	465	45	7	int:LARP1
Interaction	ZEB1 interactions	KLF8 WWTR1 ILF3 CREBBP EP300	8.10e-05	200	45	5	int:ZEB1
Interaction	BBC3 interactions	FOXO3 CREBBP EP300	8.31e-05	38	45	3	int:BBC3
Interaction	UBE2I interactions	PSME3 ILF3 UBQLN1 NACC1 CREBBP EP300 STAT3 UBQLN4	8.78e-05	654	45	8	int:UBE2I
Interaction	RBM47 interactions	KIF14 CELF1 CELF2 N4BP2 MBNL1	8.90e-05	204	45	5	int:RBM47
Interaction	RORA interactions	NCOA1 CREBBP EP300	8.99e-05	39	45	3	int:RORA
Interaction	RBMS1 interactions	UBQLN1 CELF1 CELF2 N4BP2 TNRC6A	9.53e-05	207	45	5	int:RBMS1
Interaction	CCAR2 interactions	KLF8 PSME3 CELF1 CREBBP EP300 TNRC6A	9.83e-05	337	45	6	int:CCAR2
Interaction	HNRNPUL1 interactions	KIF14 KLF8 ILF3 CELF1 EP300 STAT3	1.23e-04	351	45	6	int:HNRNPUL1
Interaction	NCOA3 interactions	NCOA1 KLF8 PSME3 CREBBP EP300	1.38e-04	224	45	5	int:NCOA3
Interaction	AGO4 interactions	KIF14 ZSWIM8 ILF3 TNRC6A	1.38e-04	118	45	4	int:AGO4
Interaction	NR3C2 interactions	NCOA1 CREBBP EP300	1.48e-04	46	45	3	int:NR3C2
Interaction	MAST1 interactions	A2M ZSWIM8 PSME3 ILF3 MRPL2	1.50e-04	228	45	5	int:MAST1
Interaction	NLRP2 interactions	NLRP2 MBNL1 NLRP5	1.57e-04	47	45	3	int:NLRP2
Interaction	RAD50 interactions	WWTR1 ILF3 NLRP2 CREBBP EP300 STAT3	1.66e-04	371	45	6	int:RAD50
Interaction	ANAPC2 interactions	KIF14 CREBBP N4BP2 EP300 TNRC6A	1.69e-04	234	45	5	int:ANAPC2
Interaction	STRBP interactions	KIF14 PSME3 ILF3 CELF1 EP300	1.69e-04	234	45	5	int:STRBP
Interaction	AP2B1 interactions	KIF14 DENND1A N4BP2 EP300 RALGAPB TNRC6A	1.71e-04	373	45	6	int:AP2B1
Interaction	KHDRBS1 interactions	KIF14 ILF3 CELF1 CREBBP EP300 STAT3	1.71e-04	373	45	6	int:KHDRBS1
Interaction	HOXB3 interactions	CREBBP EP300	1.74e-04	9	45	2	int:HOXB3
Interaction	ARGFX interactions	CREBBP EP300	1.74e-04	9	45	2	int:ARGFX
Interaction	VDR interactions	FOXO3 NCOA1 CREBBP EP300	1.83e-04	127	45	4	int:VDR
Interaction	PML interactions	KIF14 PSME3 ILF3 MDN1 CELF1 NACC1 CREBBP EP300 STAT3	1.85e-04	933	45	9	int:PML
Interaction	R3HDM2 interactions	ZSWIM8 CELF1 N4BP2 TNRC6A	1.95e-04	129	45	4	int:R3HDM2
Interaction	EYA4 interactions	NCOA1 RFX7 CREBBP EP300 TNRC6A	2.02e-04	243	45	5	int:EYA4
Interaction	PCDH8 interactions	KIF14 UBQLN4	2.17e-04	10	45	2	int:PCDH8
Interaction	PSMD3 interactions	KLF8 PSME3 ILF3 UBQLN1 EP300 UBQLN4	2.18e-04	390	45	6	int:PSMD3
Interaction	CDC27 interactions	FOXO3 ILF3 CREBBP EP300 TNRC6A	2.26e-04	249	45	5	int:CDC27
Interaction	PSMC2 interactions	KIF14 KLF8 PSME3 UBQLN1 EP300 UBQLN4	2.27e-04	393	45	6	int:PSMC2
Interaction	HK2 interactions	KIF14 UBQLN1 EP300 UBQLN4	2.32e-04	135	45	4	int:HK2
Interaction	RBM5 interactions	KIF14 ILF3 CELF1 CREBBP	2.32e-04	135	45	4	int:RBM5
Interaction	DDX5 interactions	KIF14 PSME3 ILF3 CELF1 CREBBP EP300 MBNL1	2.44e-04	568	45	7	int:DDX5
Interaction	CRX interactions	NCOA1 KMT2C SZT2 CREBBP EP300	2.47e-04	254	45	5	int:CRX
Interaction	CIITA interactions	NCOA1 CREBBP EP300	2.52e-04	55	45	3	int:CIITA
Interaction	KAT2B interactions	NCOA1 KLF8 CREBBP EP300 STAT3	2.57e-04	256	45	5	int:KAT2B
Interaction	GAS5 interactions	EP300 STAT3	2.65e-04	11	45	2	int:GAS5
Interaction	SLC45A4 interactions	UBQLN1 UBQLN4	2.65e-04	11	45	2	int:SLC45A4
Interaction	PLAAT3 interactions	UBQLN1 UBQLN4	2.65e-04	11	45	2	int:PLAAT3
Interaction	NFIB interactions	KIF14 KMT2C KLF8 CREBBP	2.81e-04	142	45	4	int:NFIB
Interaction	PSMA7 interactions	KIF14 KLF8 PSME3 UBQLN1 UBQLN4	2.86e-04	262	45	5	int:PSMA7
Interaction	PICALM interactions	KIF14 ILF3 DENND1A MBNL1 TNRC6A	2.91e-04	263	45	5	int:PICALM
Interaction	SYNM interactions	KIF14 EP300 TNRC6A	2.95e-04	58	45	3	int:SYNM
Interaction	NR1H3 interactions	FOXO3 NCOA1 EP300	2.95e-04	58	45	3	int:NR1H3
Interaction	ASH2L interactions	KIF14 KMT2C WWTR1 EP300 TNRC6A	3.01e-04	265	45	5	int:ASH2L
Interaction	PRRC2B interactions	KIF14 KLF8 WWTR1 CELF1 TNRC6A	3.01e-04	265	45	5	int:PRRC2B
Interaction	NCOA1 interactions	NCOA1 CREBBP EP300 STAT3	3.13e-04	146	45	4	int:NCOA1
Interaction	ZG16 interactions	UBQLN1 UBQLN4	3.17e-04	12	45	2	int:ZG16
Interaction	FHAD1 interactions	KIF14 KLF8	3.17e-04	12	45	2	int:FHAD1
Interaction	ELF5 interactions	KMT2C ILF3 EP300 UBQLN4	3.21e-04	147	45	4	int:ELF5
Interaction	HOXB6 interactions	PSME3 CREBBP EP300	3.26e-04	60	45	3	int:HOXB6
Interaction	IL1B interactions	ZNF675 A2M EP300	3.26e-04	60	45	3	int:IL1B
Interaction	MAF interactions	PSME3 CREBBP EP300	3.26e-04	60	45	3	int:MAF
Interaction	MAPK3 interactions	KIF14 ILF3 RFX7 CELF1 CREBBP STAT3	3.28e-04	421	45	6	int:MAPK3
GeneFamily	Zinc fingers ZZ-type\|Lysine acetyltransferases	NCOA1 CREBBP EP300	4.84e-06	17	36	3	486
GeneFamily	Ubiquilin family	UBQLN1 UBQLN4	3.84e-05	5	36	2	783
GeneFamily	Zinc fingers ZZ-type\|Lysine acetyltransferases	CREBBP EP300	5.78e-04	18	36	2	91
GeneFamily	Pyrin domain containing\|Pyrin and HIN domain family	NLRP2 NLRP5	1.12e-03	25	36	2	994
GeneFamily	NLR family	NLRP2 NLRP5	1.12e-03	25	36	2	666
Coexpression	GSE27241_WT_VS_RORGT_KO_TH17_POLARIZED_CD4_TCELL_TREATED_WITH_DIGOXIN_UP	KIF14 KMT2C RFX7 CREBBP EP300	1.41e-05	180	45	5	M8239
ToppCell	nucseq\|World / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	FOXO3 KMT2C CELF2 DENND1A MBNL1	1.64e-06	193	46	5	779276e775cb2492e8dd36436295a536084a6415
ToppCell	Tracheal-NucSeq\|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations	NCOA1 KMT2C RFX7 DENND1A TNRC6A	1.90e-06	199	46	5	94b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-Mono-Mono_hypoxia-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	KMT2C ILF3 SLC11A1 SZT2 DENND1A	1.90e-06	199	46	5	379bbd9cecf466b902411c54d74bd9885285b1ba
ToppCell	10x5'-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8\|lymph-node_spleen / Manually curated celltypes from each tissue	KMT2C CELF2 STAT3 MBNL1	4.56e-05	192	46	4	47646d7e4990be85072987f92bf18d52f8da752e
ToppCell	RV-02._Fibroblast_II\|World / Chamber and Cluster_Paper	FOXO3 NCOA1 CELF2 ABCA6	4.84e-05	195	46	4	ce90b30dcdb56d4cd925cdb79fd9d7cefd998f48
ToppCell	IPF-Lymphoid-T\|Lymphoid / Disease state, Lineage and Cell class	CELF2 N4BP2 STAT3 MBNL1	4.94e-05	196	46	4	6e70c48a63d9673eb16b0847c1bd88eecc2f7a3c
ToppCell	severe-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	KMT2C CELF2 STAT3 MBNL1	5.04e-05	197	46	4	57ebd552f10d6278623b52a3d484d4b91ae1d028
ToppCell	PCW_10-12\|World / Celltypes from embryonic and fetal-stage human lung	A2M NCOA1 CELF2 ABCA6	5.04e-05	197	46	4	47fd8b0d596c5db1a722473c8efbb17a6bbe7538
ToppCell	COVID-19\|World / Disease, condition lineage and cell class	KMT2C ILF3 STAT3 MBNL1	5.34e-05	200	46	4	7dec470c379cd89f05a0f37c8628b21f136e52f0
ToppCell	LPS_only-Hematopoietic_Erythro-Megakary\|LPS_only / Treatment groups by lineage, cell group, cell type	FOXO3 KIF14 PKHD1L1 PLCL2	5.34e-05	200	46	4	ce8281c9556a1f64f8ca8a029110077d4ef5b35e
ToppCell	LPS_only-Hematopoietic_Erythro-Megakary-Erythro-Mega-Erythroid\|LPS_only / Treatment groups by lineage, cell group, cell type	FOXO3 KIF14 PKHD1L1 PLCL2	5.34e-05	200	46	4	83c4181c083b364f0d3a89ae7a0504781fa9fa9f
ToppCell	LPS_only-Hematopoietic_Erythro-Megakary-Erythro-Mega\|LPS_only / Treatment groups by lineage, cell group, cell type	FOXO3 KIF14 PKHD1L1 PLCL2	5.34e-05	200	46	4	f15baf287ec467664c23faa53fdea45257f7b9d0
Drug	glutamin	FOXO3 NCOA1 PSME3 UBQLN1 CREBBP EP300 MBNL1 UBQLN4	2.97e-06	461	45	8	CID000000738
Drug	LYR 71	EP300 STAT3	2.29e-05	4	45	2	ctd:C530478
Drug	3,4-dimethoxy-N-((2,2-dimethyl-2H-chromen-6-yl)methyl)-N-phenylbenzenesulfonamide	CREBBP EP300	3.81e-05	5	45	2	ctd:C575894
Drug	Medrysone [2668-66-8]; Down 200; 11.6uM; PC3; HT_HG-U133A	ZNF675 SZT2 MBNL1 PLCL2 SOS2	4.05e-05	195	45	5	3705_DN
Drug	Lisuride (S)(-) [18016-80-3]; Up 200; 11.8uM; MCF7; HT_HG-U133A	ZNF675 CD1E SLC11A1 SZT2 SOS2	4.05e-05	195	45	5	1545_UP
Drug	Ivermectin [70288-86-7]; Down 200; 4.6uM; HL60; HG-U133A	NCOA1 ILF3 SLC11A1 RFX7 MRPL2	4.15e-05	196	45	5	1367_DN
Drug	Gabexate mesilate [56974-61-9]; Up 200; 9.6uM; MCF7; HT_HG-U133A	ZNF675 CELF2 EP300 MBNL1 SOS2	4.36e-05	198	45	5	4804_UP
Drug	Karakoline [39089-30-0]; Down 200; 10.6uM; HL60; HT_HG-U133A	A2M CD1E PSME3 SLC11A1 PLCL2	4.46e-05	199	45	5	2203_DN
Drug	Hydrocortisone base [50-23-7]; Down 200; 11uM; MCF7; HT_HG-U133A	ZNF675 ZSWIM8 WWTR1 CREBBP MBNL1	4.57e-05	200	45	5	5284_DN
Disease	Menke-Hennekam syndrome	CREBBP EP300	2.17e-06	2	44	2	cv:C5681632
Disease	Rubinstein-Taybi syndrome (implicated_via_orthology)	CREBBP EP300	2.17e-06	2	44	2	DOID:1933 (implicated_via_orthology)
Disease	Rubinstein-Taybi syndrome	CREBBP EP300	2.17e-06	2	44	2	cv:C0035934
Disease	RUBINSTEIN-TAYBI SYNDROME 1	CREBBP EP300	2.17e-06	2	44	2	C4551859
Disease	RUBINSTEIN-TAYBI SYNDROME 1	CREBBP EP300	2.17e-06	2	44	2	180849
Disease	Rubinstein-Taybi syndrome due to CREBBP mutations	CREBBP EP300	2.17e-06	2	44	2	cv:C4551859
Disease	Rubinstein-Taybi syndrome (is_implicated_in)	CREBBP EP300	2.17e-06	2	44	2	DOID:1933 (is_implicated_in)
Disease	Rubinstein-Taybi Syndrome	CREBBP EP300	2.17e-06	2	44	2	C0035934
Disease	amyotrophic lateral sclerosis type 15 (implicated_via_orthology)	UBQLN1 UBQLN4	6.51e-06	3	44	2	DOID:0060206 (implicated_via_orthology)
Disease	Adenoid Cystic Carcinoma	FOXO3 KMT2C CREBBP EP300	1.52e-05	100	44	4	C0010606
Disease	Carcinoma, Transitional Cell	KMT2C CREBBP EP300	3.17e-05	41	44	3	C0007138
Disease	lymphoproliferative syndrome (is_implicated_in)	SLC11A1 STAT3	3.25e-05	6	44	2	DOID:0060704 (is_implicated_in)
Disease	mood instability measurement	CELF1 EP300 PLCL2 TNRC6A	4.01e-05	128	44	4	EFO_0008475
Disease	prostate cancer (is_marker_for)	FOXO3 NCOA1 KMT2C EP300	8.65e-05	156	44	4	DOID:10283 (is_marker_for)
Disease	Leukemia, Myelocytic, Acute	KMT2C CREBBP EP300 STAT3	1.29e-04	173	44	4	C0023467
Disease	frontotemporal dementia (implicated_via_orthology)	UBQLN1 UBQLN4	1.42e-04	12	44	2	DOID:9255 (implicated_via_orthology)
Disease	neuroticism measurement, cognitive function measurement	FOXO3 CELF2 DENND1A N4BP2 PLCL2 TNRC6A	1.84e-04	566	44	6	EFO_0007660, EFO_0008354
Disease	T-Cell Lymphoma	EP300 STAT3	2.57e-04	16	44	2	C0079772
Disease	heart disease (biomarker_via_orthology)	EP300 STAT3	2.91e-04	17	44	2	DOID:114 (biomarker_via_orthology)
Disease	ulcerative colitis (is_implicated_in)	SLC11A1 STAT3	2.91e-04	17	44	2	DOID:8577 (is_implicated_in)
Disease	squamous cell carcinoma (is_implicated_in)	KMT2C STAT3	3.27e-04	18	44	2	DOID:1749 (is_implicated_in)
Disease	Squamous cell carcinoma of esophagus	KMT2C CREBBP EP300	3.89e-04	95	44	3	C0279626
Disease	Pancreatic Neoplasm	EP300 STAT3 ANXA10	4.52e-04	100	44	3	C0030297
Disease	Malignant neoplasm of pancreas	EP300 STAT3 ANXA10	4.79e-04	102	44	3	C0346647
Disease	idiopathic pulmonary fibrosis (is_marker_for)	EP300 STAT3	5.39e-04	23	44	2	DOID:0050156 (is_marker_for)
Disease	Sezary Syndrome	KMT2C CREBBP	7.45e-04	27	44	2	C0036920
Disease	Squamous cell carcinoma	CREBBP EP300 STAT3	8.46e-04	124	44	3	C0007137
Disease	Drug-Induced Stevens Johnson Syndrome	CELF2 EP300	8.60e-04	29	44	2	C1274933
Disease	Toxic Epidermal Necrolysis	CELF2 EP300	8.60e-04	29	44	2	C0014518
Disease	Mycoplasma-Induced Stevens-Johnson Syndrome	CELF2 EP300	8.60e-04	29	44	2	C3658301
Disease	Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Spectrum	CELF2 EP300	8.60e-04	29	44	2	C3658302
Disease	amyotrophic lateral sclerosis (implicated_via_orthology)	UBQLN1 UBQLN4	9.21e-04	30	44	2	DOID:332 (implicated_via_orthology)
Disease	Crohn's disease (is_implicated_in)	SLC11A1 STAT3	9.21e-04	30	44	2	DOID:8778 (is_implicated_in)
Disease	Stevens-Johnson Syndrome	CELF2 EP300	9.21e-04	30	44	2	C0038325
Disease	pulse pressure measurement	FOXO3 KLF8 CELF1 CELF2 STAT3 MBNL1 TNRC6A SOS2	9.34e-04	1392	44	8	EFO_0005763
Disease	verbal-numerical reasoning measurement	FOXO3 PLCL2 TNRC6A	9.91e-04	131	44	3	EFO_0008394
Disease	peptic ulcer disease	PLCL2 UBQLN4	1.11e-03	33	44	2	MONDO_0004247
Disease	Bladder Neoplasm	KMT2C CREBBP EP300	1.20e-03	140	44	3	C0005695
Disease	Malignant neoplasm of urinary bladder	KMT2C CREBBP EP300	1.23e-03	141	44	3	C0005684
Disease	Behcet's disease (is_implicated_in)	SLC11A1 STAT3	1.33e-03	36	44	2	DOID:13241 (is_implicated_in)
Disease	neurodegenerative disease (implicated_via_orthology)	WWTR1 UBQLN1 UBQLN4	1.33e-03	145	44	3	DOID:1289 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
ITPQSGLNQFGQMSM	EP300	706	Q09472
SMLSQLASNPGMANL	EP300	2371	Q09472
FSGIQQMAGMNALQL	CELF2	266	O95319
QMAGMNALQLQNLAT	CELF2	271	O95319
NFNPIMDAQMLGGAL	ANXA10	16	Q9UJ72
HPMGGLNAMQLQNLA	CELF1	251	Q92879
ILMNIISNGLLQMFN	ABCA6	976	Q8N139
MNSFNPMSLGNVQLP	CREBBP	721	Q92793
NNMMAQAPAQSQFLP	CREBBP	781	Q92793
GSAMQNTQNLLQMPY	A2M	956	P01023
GIMFQMDNHLPNLVN	KIF14	791	Q15058
NPALLSQNSMQAVML	MDN1	3611	Q9NU22
QGNMPGLQSTFLAMD	NRBP2	46	Q9NSY0
HNQDAFSRMPLMNGL	KMT2C	1551	Q8NEZ4
NIMLLLGGFNTNNMN	LIPM	271	Q5VYY2
SLQGLQQEPAAMAQM	KLF8	246	O95600
SMPTLMQEFANGLLN	SLC11A1	451	P49279
MVSSAQMGFNLQALL	NLRP2	1	Q9NX02
SLNLVQNNFSPKGMM	NLRP5	1126	P59047
LAGCRMNAPQIFLNM	CD1E	126	P15812
MNAPQIFLNMAYQGS	CD1E	131	P15812
NMQNMRLGPSFILTG	LINC02876	41	F2Z3M2
QAMNALMRLNQLKPG	ILF3	401	Q12906
LAQQMQLANAMMPGA	MBNL1	96	Q9NR56
NLSALSMPNLFGQMP	DENND1A	886	Q8TEH3
GSFLQLSMMPQRAGN	KRBA2	76	Q6ZNG9
MMNLKGNPELSQSNL	NUBPL	116	Q8TB37
NFNMMNALDQLPKPF	FNDC8	21	Q8TC99
MMSFAAQPNQGSLVN	FOXO3	516	O43524
MGLLPQCQQLQMFFL	SZT2	996	Q5T011
PMGQAVNSQLSMLFT	SZT2	3016	Q5T011
LNQAITALMNLQGSM	SOS2	371	Q07890
RAMLMRQQSFGNNLP	NCOA1	1131	Q15788
AMNFQTPGLMMDLNI	PLCL2	701	Q9UPR0
VFVMPNGMLKSNQQL	PSME3	101	P61289
CLNPAQQNLYMNVML	ZNF431	51	Q8TF32
GANPNLRNFNMMAPL	TRPA1	121	O75762
MSPRTLDSLMQFGNN	STAT3	726	P40763
MFNTPGMQSLLQQIT	UBQLN1	371	Q9UMX0
QMMLNNPLFAGNPQL	UBQLN1	416	Q9UMX0
SLFPAAQMMNNGLLQ	MRPL2	26	Q5T653
AQMMNNGLLQQPSAL	MRPL2	31	Q5T653
LGMNNLPSNYTARMN	RFX7	1171	Q2KHR2
MFNIIDMRNGSSNPL	PKHD1L1	2936	Q86WI1
PNNTQMILGAMLNIV	RALGAPB	676	Q86X10
GLNQCLPTMQSKMFQ	ZNF675	131	Q8TD23
TPMGMMQFNDILQNL	ZSWIM8	1801	A7E2V4
GMFNSPEMQALLQQI	UBQLN4	376	Q9NRR5
LMQQMIQLLAGSGNS	UBQLN4	536	Q9NRR5
FPIGLNSNLNVNMDM	TNRC6A	1511	Q8NDV7
AGLMSMPNALTTQQQ	WWTR1	216	Q9GZV5
LNGLKPAGMAQLTNM	MORN5	96	Q5VZ52
MAQTLQMEIPNFGNS	NACC1	1	Q96RE7
NMTPIFSTQNMNLNG	N4BP2	186	Q86UW6