Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ATP-dependent chromatin remodeler activity	EP400 CHD9 CHD3	1.15e-04	37	51	3	GO:0140658
GeneOntologyMolecularFunction	catalytic activity, acting on a nucleic acid	EP400 EXD2 CHD9 CHD3 SLFN14 FANCM DUS3L FTSJ3	2.12e-04	645	51	8	GO:0140640
GeneOntologyMolecularFunction	ATP-dependent activity, acting on DNA	EP400 CHD9 CHD3 FANCM	3.09e-04	127	51	4	GO:0008094
GeneOntologyMolecularFunction	chloride:bicarbonate antiporter activity	SLC4A3 SLC4A2	4.90e-04	13	51	2	GO:0140900
GeneOntologyMolecularFunction	bicarbonate:monoatomic anion antiporter activity	SLC4A3 SLC4A2	4.90e-04	13	51	2	GO:0140829
GeneOntologyMolecularFunction	catalytic activity, acting on DNA	EP400 EXD2 CHD9 CHD3 FANCM	5.37e-04	262	51	5	GO:0140097
GeneOntologyMolecularFunction	helicase activity	EP400 CHD9 CHD3 FANCM	7.06e-04	158	51	4	GO:0004386
MousePheno	azoospermia	RHBDF2 MAP2 CNBD2 FANCM SLC4A2 MYBL1	1.98e-05	244	33	6	MP:0005159
MousePheno	absent gametes	RHBDF2 MAP2 CNBD2 FANCM SLC4A2 MYBL1	2.60e-05	256	33	6	MP:0001117
Domain	Anion_exchange_CS	SLC4A3 SLC4A2	2.28e-05	3	52	2	IPR018241
Domain	Anion_exchange	SLC4A3 SLC4A2	7.56e-05	5	52	2	IPR001717
Domain	SNF2_N	EP400 CHD9 CHD3	9.54e-05	32	52	3	PF00176
Domain	SNF2_N	EP400 CHD9 CHD3	9.54e-05	32	52	3	IPR000330
Domain	Myb-like_dom	MYPOP EP400	1.13e-04	6	52	2	IPR017877
Domain	DNA/RNA_helicase_DEAH_CS	EP400 CHD3 FANCM	1.25e-04	35	52	3	IPR002464
Domain	ANION_EXCHANGER_2	SLC4A3 SLC4A2	1.58e-04	7	52	2	PS00220
Domain	ANION_EXCHANGER_1	SLC4A3 SLC4A2	1.58e-04	7	52	2	PS00219
Domain	DEAH_ATP_HELICASE	EP400 CHD3 FANCM	1.60e-04	38	52	3	PS00690
Domain	MYB_LIKE	MYPOP EP400 MYBL1	1.60e-04	38	52	3	PS50090
Domain	Helicase_C	EP400 CHD9 CHD3 FANCM	2.23e-04	107	52	4	PF00271
Domain	HELICc	EP400 CHD9 CHD3 FANCM	2.23e-04	107	52	4	SM00490
Domain	Helicase_C	EP400 CHD9 CHD3 FANCM	2.31e-04	108	52	4	IPR001650
Domain	HELICASE_CTER	EP400 CHD9 CHD3 FANCM	2.40e-04	109	52	4	PS51194
Domain	HELICASE_ATP_BIND_1	EP400 CHD9 CHD3 FANCM	2.40e-04	109	52	4	PS51192
Domain	DEXDc	EP400 CHD9 CHD3 FANCM	2.40e-04	109	52	4	SM00487
Domain	Helicase_ATP-bd	EP400 CHD9 CHD3 FANCM	2.48e-04	110	52	4	IPR014001
Domain	Band3_cytoplasmic_dom	SLC4A3 SLC4A2	2.70e-04	9	52	2	IPR013769
Domain	Band_3_cyto	SLC4A3 SLC4A2	2.70e-04	9	52	2	PF07565
Domain	-	SLC4A3 SLC4A2	2.70e-04	9	52	2	3.40.1100.10
Domain	PTrfase/Anion_transptr	SLC4A3 SLC4A2	3.37e-04	10	52	2	IPR016152
Domain	HCO3_cotransp	SLC4A3 SLC4A2	3.37e-04	10	52	2	PF00955
Domain	HCO3_transpt_euk	SLC4A3 SLC4A2	3.37e-04	10	52	2	IPR003020
Domain	HCO3_transpt_C	SLC4A3 SLC4A2	3.37e-04	10	52	2	IPR011531
Domain	SANT	MYPOP EP400 MYBL1	3.64e-04	50	52	3	SM00717
Domain	SANT/Myb	MYPOP EP400 MYBL1	4.09e-04	52	52	3	IPR001005
Domain	DUF4599	SPATA31D1 SPATA31C2	4.93e-04	12	52	2	PF15371
Domain	DUF4599	SPATA31D1 SPATA31C2	4.93e-04	12	52	2	IPR027970
Domain	Chromo_domain	CHD9 CHD3	2.02e-03	24	52	2	IPR023780
Domain	Chromo	CHD9 CHD3	2.37e-03	26	52	2	PF00385
Domain	CHROMO_2	CHD9 CHD3	2.74e-03	28	52	2	PS50013
Domain	CHROMO_1	CHD9 CHD3	2.74e-03	28	52	2	PS00598
Domain	Chromodomain-like	CHD9 CHD3	3.57e-03	32	52	2	IPR016197
Domain	CHROMO	CHD9 CHD3	3.80e-03	33	52	2	SM00298
Domain	Chromo/shadow_dom	CHD9 CHD3	3.80e-03	33	52	2	IPR000953
Pubmed	Human intestinal anion exchanger isoforms: expression, distribution, and membrane localization.	SLC4A3 SLC4A2	2.28e-06	2	53	2	11248201
Pubmed	cDNA cloning and tissue distribution of mRNAs for two proteins that are related to the band 3 Cl-/HCO3- exchanger.	SLC4A3 SLC4A2	2.28e-06	2	53	2	2294114
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	SRRM1 RPL29 RPL31 MYPOP EP400 GPATCH4 CHD3 ARHGAP11A FANCM BAP1 FTSJ3	3.28e-06	1294	53	11	30804502
Pubmed	Expression and function of bicarbonate/chloride exchangers in the preimplantation mouse embryo.	SLC4A3 SLC4A2	6.83e-06	3	53	2	7592657
Pubmed	Pendrin: an apical Cl-/OH-/HCO3- exchanger in the kidney cortex.	SLC4A3 SLC4A2	6.83e-06	3	53	2	11208611
Pubmed	Identification of an apical Cl(-)/HCO3(-) exchanger in the small intestine.	SLC4A3 SLC4A2	1.36e-05	4	53	2	11842009
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	SRRM1 CHD9 GPATCH4 CHD3 PHAX ARHGAP11A BAP1	3.70e-05	608	53	7	36089195
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	SRRM1 SP100 EP400 CHD9 GPATCH4 CHD3 PLEKHN1 TRIP4 FTSJ3	4.35e-05	1116	53	9	31753913
Pubmed	Chloride Accumulators NKCC1 and AE2 in Mouse GnRH Neurons: Implications for GABAA Mediated Excitation.	SLC4A3 SLC4A2	6.34e-05	8	53	2	26110920
Pubmed	Chromosomal location of the murine anion exchanger genes encoding AE2 and AE3.	SLC4A3 SLC4A2	6.34e-05	8	53	2	7894173
Pubmed	Charting the landscape of tandem BRCT domain-mediated protein interactions.	CNTN4 SRRM1 FLII RPL29 GPATCH4 PHAX FANCM	6.82e-05	670	53	7	22990118
Pubmed	FBXO42 facilitates Notch signaling activation and global chromatin relaxation by promoting K63-linked polyubiquitination of RBPJ.	FLII SP100 CHD9 CHD3	1.78e-04	183	53	4	36129980
Pubmed	Ubiquitin-Independent Disassembly by a p97 AAA-ATPase Complex Drives PP1 Holoenzyme Formation.	SRRM1 FLII RPL29 RPL31 FTSJ3	2.23e-04	361	53	5	30344098
Pubmed	TRIM65 regulates microRNA activity by ubiquitination of TNRC6.	SRRM1 GPATCH4 PRR14L PHAX FTSJ3	2.32e-04	364	53	5	24778252
Pubmed	Unpackaging the genetics of mammalian fertility: strategies to identify the "reproductive genome".	MAP2 MYBL1	2.70e-04	16	53	2	29878059
Pubmed	CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.	SRRM1 RPL31 GPATCH4 CHD3 TRIP4 FTSJ3	3.10e-04	605	53	6	28977666
Pubmed	WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage.	SRRM1 EP400 CHD9 CHD3 FTSJ3	3.34e-04	394	53	5	27248496
Pubmed	SPOP promotes ATF2 ubiquitination and degradation to suppress prostate cancer progression.	SRRM1 CHD3	3.43e-04	18	53	2	29996942
Pubmed	The cell proliferation antigen Ki-67 organises heterochromatin.	RPL29 EP400 GPATCH4 CHD3 FTSJ3	4.01e-04	410	53	5	26949251
Pubmed	RioK1, a new interactor of protein arginine methyltransferase 5 (PRMT5), competes with pICln for binding and modulates PRMT5 complex composition and substrate specificity.	RPL29 RPL31 CHD3 PHAX FTSJ3	4.72e-04	425	53	5	21081503
Pubmed	SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.	SRRM1 RPL29 RPL31 GPATCH4 CHD3 FTSJ3	4.72e-04	655	53	6	35819319
Pubmed	Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.	SRRM1 FLII EXD2 CHD9 GPATCH4 ARHGAP11A SLC4A2	4.89e-04	925	53	7	28986522
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	RPL29 EP400 GPATCH4 CHD3 PRR14L PHAX FTSJ3	5.18e-04	934	53	7	33916271
Pubmed	Identification of proteins associated with ligand-activated estrogen receptor α in human breast cancer cell nuclei by tandem affinity purification and nano LC-MS/MS.	SRRM1 RPL29 EP400 FTSJ3	5.37e-04	245	53	4	21182205
Pubmed	Targeted and Interactome Proteomics Revealed the Role of PHD2 in Regulating BRD4 Proline Hydroxylation.	SRRM1 FLII RPL29 RPL31 FTSJ3	5.57e-04	441	53	5	31239290
Pubmed	Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.	SRRM1 FLII RPL29 RPL31 CHD9 GPATCH4 TRIP4 FTSJ3	5.64e-04	1247	53	8	27684187
Pubmed	Helios expression coordinates the development of a subset of striatopallidal medium spiny neurons.	MAP2 IKZF5	5.65e-04	23	53	2	28289129
Pubmed	SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors.	FLII RPL31 CHD3 FTSJ3	5.79e-04	250	53	4	33536335
Pubmed	TWIST1 and chromatin regulatory proteins interact to guide neural crest cell differentiation.	RPL29 CHD9 FTSJ3	6.26e-04	109	53	3	33554859
Pubmed	SNIP1 Recruits TET2 to Regulate c-MYC Target Genes and Cellular DNA Damage Response.	SRRM1 RPL29 RPL31 FTSJ3	6.61e-04	259	53	4	30404004
Pubmed	RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease.	SRRM1 RPL29 RPL31 GPATCH4 PHAX FTSJ3	7.36e-04	713	53	6	29802200
Pubmed	Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair.	FLII RPL29 RPL31 EXD2 CHD3 PHAX DUS3L TRIP4	8.80e-04	1335	53	8	29229926
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	SRRM1 FLII RPL29 EP400 EXD2 CHD3 FTSJ3	8.90e-04	1024	53	7	24711643
Pubmed	KAP1 Recruitment of the 7SK snRNP Complex to Promoters Enables Transcription Elongation by RNA Polymerase II.	RPL29 RPL31 PHAX FTSJ3	8.95e-04	281	53	4	26725010
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	FLII RPL29 RPL31 EP400 GPATCH4 PRR14L DUS3L FTSJ3	9.59e-04	1353	53	8	29467282
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	FLII RPL31 GPATCH4 CHD3 PHAX FTSJ3	1.02e-03	759	53	6	35915203
Pubmed	Polymorphic variants in hereditary pancreatic cancer genes are not associated with pancreatic cancer risk.	SEM1 FANCM	1.03e-03	31	53	2	19690177
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	SRRM1 FLII EP400 GPATCH4 CHD3 PHAX TRIP4 FTSJ3	1.04e-03	1371	53	8	36244648
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	SRRM1 FLII EP400 CHD3 PLCB3 BAP1	1.12e-03	774	53	6	15302935
Pubmed	R2TP/Prefoldin-like component RUVBL1/RUVBL2 directly interacts with ZNHIT2 to regulate assembly of U5 small nuclear ribonucleoprotein.	SRRM1 RPL31 EP400 FTSJ3	1.14e-03	300	53	4	28561026
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	SRRM1 RPL29 RPL31 EP400 EXD2 GPATCH4	1.15e-03	777	53	6	35844135
Pubmed	Genetic mapping of the human and mouse phospholipase C genes.	MAP2 PLCB3	1.17e-03	33	53	2	8672127
Pubmed	Proteomic analysis and identification of cellular interactors of the giant ubiquitin ligase HERC2.	FLII EXD2 PRR14L	1.26e-03	139	53	3	25476789
Pubmed	Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.	SRRM1 FLII CHD9 CHD3 FTSJ3	1.30e-03	533	53	5	30554943
Pubmed	Human transcription factor protein interaction networks.	RPL31 EP400 GPATCH4 CHD3 VSX1 IKZF5 BAP1 FTSJ3	1.36e-03	1429	53	8	35140242
Pubmed	Genetic mapping of the mouse ferritin light chain gene and 11 pseudogenes on 11 mouse chromosomes.	MAP2 PLCB3	1.39e-03	36	53	2	9457670
Pubmed	Nuclear Functions of Nucleolin through Global Proteomics and Interactomic Approaches.	SRRM1 RPL31 FTSJ3	1.43e-03	145	53	3	27049334
Interaction	NES interactions	SRRM1 FLII GPATCH4 RSPRY1 BAP1 FTSJ3	1.78e-06	152	49	6	int:NES
Interaction	GPATCH4 interactions	SP100 RPL31 GPATCH4 CHD3 TRIP4 FTSJ3	2.02e-05	232	49	6	int:GPATCH4
Interaction	RPL28 interactions	SRRM1 RPL29 RPL31 KIAA0232 CHD3 TRIP4 BAP1 FTSJ3	2.30e-05	494	49	8	int:RPL28
Interaction	H1-2 interactions	SRRM1 RPL29 SP100 RPL31 EP400 CHD3 PHAX BAP1 FTSJ3	2.80e-05	666	49	9	int:H1-2
GeneFamily	GATA zinc finger domain containing\|Myb/SANT domain containing	MYPOP EP400 MYBL1	1.46e-04	53	35	3	532
GeneFamily	PHD finger proteins	SP100 PHF11 CHD3	6.96e-04	90	35	3	88
Computational	Neighborhood of REV3L	EP400 ZNF500 CHD9 CHD3	1.42e-05	58	28	4	MORF_REV3L
Computational	Neighborhood of RFC5	EP400 CHD9 ARHGAP11A SLC4A3	4.60e-05	78	28	4	MORF_RFC5
Computational	Neighborhood of BRCA1	EP400 MAP2 ZNF500 CHD9 ARHGAP11A SLC4A3	4.85e-05	263	28	6	MORF_BRCA1
Computational	Neighborhood of PSMF1	EP400 ZNF500 CHD9 CHD3 SLC4A3	6.27e-05	167	28	5	MORF_PSMF1
Computational	Neighborhood of ATRX	EP400 ZNF500 CHD9 CHD3 SLC4A3	2.06e-04	215	28	5	MORF_ATRX
Computational	Neighborhood of CDC2L5	EP400 ZNF500 CHD9 CHD3	4.67e-04	142	28	4	MORF_CDC2L5
Computational	Neighborhood of RUNX1	EP400 ZNF500 CHD9 SLC4A3	6.04e-04	152	28	4	MORF_RUNX1
Computational	Neighborhood of FANCG	ZNF500 CHD9 CHD3 SLC4A3	8.60e-04	167	28	4	MORF_FANCG
Computational	Neighborhood of ESR1	EP400 ZNF500 CHD9 SLC4A3	9.60e-04	172	28	4	MORF_ESR1
Computational	Neighborhood of HEAB	ZNF500 CHD9 CHD3	1.27e-03	83	28	3	MORF_HEAB
Computational	Genes in the cancer module 168.	MAP2 CHD3	1.46e-03	22	28	2	MODULE_168
Computational	Neighborhood of PPP5C	EP400 ZNF500 CHD3	1.65e-03	91	28	3	MORF_PPP5C
Computational	Neighborhood of RBBP8	ZNF500 CHD9 CHD3 SLC4A3	2.11e-03	213	28	4	MORF_RBBP8
Computational	Neighborhood of ERCC2	ZNF500 CHD9 CHD3	2.42e-03	104	28	3	MORF_ERCC2
Disease	anemia (implicated_via_orthology)	SLC4A3 SLC4A2	3.03e-04	15	51	2	DOID:2355 (implicated_via_orthology)
Disease	Malignant Head and Neck Neoplasm	FANCM BAP1	2.65e-03	44	51	2	C0278996

Protein segments in the cluster

Peptide	Gene	Start	Entry
RKKKQRHGEAVVPPR	EP400	2301	Q96L91
VPGVRRHLVRKNAKG	SLC4A2	281	P04920
RRHLVKKPSRTQGGR	SLC4A3	281	P48751
RADGKPIARKARRHK	CNTN4	261	Q8IWV2
IGRLHKQRKPDRRKR	BAP1	706	Q92560
SEGRRKIQRRHKKPL	CFAP92	346	Q9ULG3
KRARGQNKGRPHVKP	DUS3L	101	Q96G46
QKQSKQRKRGRHGPR	H2BW1	56	Q7Z2G1
KQVLGGLRKKRRPCH	FGFBP3	111	Q8TAT2
RKFIIHRGKRKAVQG	FLII	1036	Q13045
KGEKRPRPNHKAVAR	KIAA0895	36	Q8NCT3
KKQQPRKAHRAHRGR	IHO1	441	Q8IYA8
RKGKRARRQGHVNLP	KIAA1109	2491	Q2LD37
ARRGIKVPKRQSHLK	FANCM	1491	Q8IYD8
QGRDPRKHKRKPLGV	EXD2	331	Q9NVH0
RGKRKRQQHPKKERA	GPATCH4	416	Q5T3I0
RHKAREIRNKKGRNG	KIAA0232	316	Q92628
HRRRKHKMVPIKGTR	IKZF5	156	Q9H5V7
GRILVKNKKRHRPSA	PLCB3	461	Q01970
PIVKKRRGRRKNVEG	CHD9	2426	Q3L8U1
RRHGVRAKVQPQARK	CPN1	431	P15169
GTGPGRKRRRKHREK	CHD3	96	Q12873
SRKVPGAQKRRHKPR	IFNL4	131	K9M1U5
KEAKHLGPHRRREKG	FAM186A	951	A6NE01
SKQGHKRLIKGVRRV	H1-9P	211	P60008
KKARVGPHVRQGKRR	HHIPL2	686	Q6UWX4
ILRKKRKMRVGHSPG	MYBL1	446	P10243
PRKRRARGKVKVAGS	PRR14L	2096	Q5THK1
HLKRKRPVKDRLGNR	PHAX	196	Q9H814
HPKLGKRARARIAKG	RPL29	101	P47914
PGKHKKRRGATRERV	RPUSD2	96	Q8IZ73
RHRKKPRDKESVGLG	SYT8	76	Q8NBV8
AGVPRRSKRIAGKKV	ARHGAP11A	396	Q6P4F7
RAQRGRPRVKKLHPQ	SLFN14	156	P0C7P3
FKKGRRRVPVRNLGK	PLEKHN1	81	Q494U1
RGRGPHEPRRKKQNV	RSPRY1	86	Q96DX4
KRKRHLVSQRPAGRR	SPATA31C2	61	B4DYI2
VVAKKGVGRKVRRPA	FTSJ3	801	Q8IY81
RKHGIKRGRRPSIRS	SEM1	21	Q6ZVN7
HREKRRQRNKGGPKW	SEMA3D	736	O95025
KRHKGRKLTVPVRRH	CHSY3	546	Q70JA7
RFGRRRVIIKKGQKG	CNBD2	136	Q96M20
SPTLGKRKKRRHRTV	VSX1	156	Q9NZR4
KRIHGVGFKKRAPRA	RPL31	31	P62899
ARGRLKQRGKKAVPV	SLC35B2	411	Q8TB61
QKHQGRAKRRRKGGT	SPATA31D1	61	Q6ZQQ2
RPKRSHVKNGEVGRR	SRRM1	506	Q8IYB3
GKRRKKRRHRSKVNG	SP100	531	P23497
RKRGRKKPLSGNHVQ	PHF11	176	Q9UIL8
LKNIRHRPGGGRVKI	MAP2	1711	P11137
HLKRGRKKGRNRQEV	TRIP4	101	Q15650
GPRRGKRIASKVKHF	RHBDF2	346	Q6PJF5
EGLQRKPRKHRQRGS	ZNF500	126	O60304
KGGHVQREKAPRRRS	WDR64	1046	B1ANS9
HKRRKGFPTRKRRGR	MYPOP	381	Q86VE0