Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	palmitoyl-CoA 9-desaturase activity	SCD5 SCD	2.04e-06	2	29	2	GO:0032896
GeneOntologyMolecularFunction	stearoyl-CoA 9-desaturase activity	SCD5 SCD	1.22e-05	4	29	2	GO:0004768
GeneOntologyMolecularFunction	acyl-CoA desaturase activity	SCD5 SCD	2.03e-05	5	29	2	GO:0016215
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	SCD5 SCD	1.57e-04	13	29	2	GO:0016717
GeneOntologyBiologicalProcess	monounsaturated fatty acid biosynthetic process	SCD5 SCD	1.91e-06	2	29	2	GO:1903966
GeneOntologyBiologicalProcess	tarsal gland development	SCD5 SCD	5.72e-06	3	29	2	GO:1903699
GeneOntologyBiologicalProcess	monounsaturated fatty acid metabolic process	SCD5 SCD	5.72e-06	3	29	2	GO:1903964
GeneOntologyBiologicalProcess	sulfur amino acid metabolic process	MPST DPEP1 CSAD	2.38e-05	40	29	3	GO:0000096
GeneOntologyBiologicalProcess	sulfur compound catabolic process	MPST DPEP1 CSAD	5.58e-05	53	29	3	GO:0044273
GeneOntologyBiologicalProcess	sulfur amino acid catabolic process	MPST CSAD	1.04e-04	11	29	2	GO:0000098
GeneOntologyBiologicalProcess	homocysteine metabolic process	MPST DPEP1	1.98e-04	15	29	2	GO:0050667
GeneOntologyBiologicalProcess	sebaceous gland development	SCD5 SCD	1.98e-04	15	29	2	GO:0048733
GeneOntologyBiologicalProcess	cysteine metabolic process	MPST CSAD	2.26e-04	16	29	2	GO:0006534
GeneOntologyBiologicalProcess	white fat cell differentiation	SCD5 SCD	5.61e-04	25	29	2	GO:0050872
MousePheno	small perianal sebaceous gland	SCD5 SCD	7.09e-06	3	22	2	MP:0013382
MousePheno	abnormal perianal sebaceous gland morphology	SCD5 SCD	7.09e-06	3	22	2	MP:0013381
MousePheno	blindness	STRA6 SCD5 SCD	1.34e-05	30	22	3	MP:0002001
MousePheno	sebaceous gland atrophy	SCD5 SCD	1.42e-05	4	22	2	MP:0000649
MousePheno	enlarged hair follicles	SCD5 SCD	2.36e-05	5	22	2	MP:0000381
MousePheno	increased saturated fatty acids level	SCD5 SCD	2.36e-05	5	22	2	MP:0005284
MousePheno	photophobia	SCD5 SCD	2.36e-05	5	22	2	MP:0013787
MousePheno	sebaceous gland hypoplasia	SCD5 SCD	4.94e-05	7	22	2	MP:0013193
MousePheno	matted coat	SCD5 SCD	4.94e-05	7	22	2	MP:0003846
MousePheno	Meibomian gland atrophy	SCD5 SCD	4.94e-05	7	22	2	MP:0001345
MousePheno	abnormal cutaneous elastic fiber morphology	SCD5 SCD	6.58e-05	8	22	2	MP:0008418
MousePheno	abnormal behavioral response to light	SCD5 SCD	6.58e-05	8	22	2	MP:0011275
MousePheno	small Meibomian gland	SCD5 SCD	8.46e-05	9	22	2	MP:0013388
MousePheno	distorted hair follicle pattern	SCD5 SCD	8.46e-05	9	22	2	MP:0000384
MousePheno	progressive hair loss	SCD5 SCD	8.46e-05	9	22	2	MP:0009004
MousePheno	decreased unsaturated fatty acids level	SCD5 SCD	1.06e-04	10	22	2	MP:0005285
MousePheno	photosensitivity	SCD5 SCD	1.06e-04	10	22	2	MP:0001999
MousePheno	abnormal sebocyte morphology	SCD5 SCD	1.29e-04	11	22	2	MP:0013375
MousePheno	abnormal sebaceous lipid secretion	SCD5 SCD	1.29e-04	11	22	2	MP:0002992
MousePheno	abnormal piliary canal morphology	SCD5 SCD	1.55e-04	12	22	2	MP:0030570
MousePheno	abnormal hair follicle bulb morphology	SCD5 SCD	1.55e-04	12	22	2	MP:0010681
MousePheno	abnormal hair follicle outer root sheath morphology	SCD5 SCD	2.80e-04	16	22	2	MP:0010684
MousePheno	orthokeratosis	SCD5 SCD	2.80e-04	16	22	2	MP:0009675
MousePheno	short hair	SCD5 SCD	2.80e-04	16	22	2	MP:0000417
MousePheno	abnormal hair follicle inner root sheath morphology	SCD5 SCD	3.17e-04	17	22	2	MP:0010685
MousePheno	abnormal vision	STRA6 SCD5 SCD	3.52e-04	89	22	3	MP:0002090
MousePheno	abnormal sebaceous gland physiology	SCD5 SCD	4.42e-04	20	22	2	MP:0002991
MousePheno	abnormal holocrine gland physiology	SCD5 SCD	4.42e-04	20	22	2	MP:0013556
MousePheno	flaky skin	SCD5 SCD	4.88e-04	21	22	2	MP:0001195
MousePheno	eyelids fail to open	SCD5 SCD	4.88e-04	21	22	2	MP:0005176
MousePheno	renal glomerulus cyst	PKHD1 LTBP1	4.88e-04	21	22	2	MP:0011682
MousePheno	thick dermal layer	SCD5 SCD	5.36e-04	22	22	2	MP:0001245
MousePheno	small sebaceous gland	SCD5 SCD	5.86e-04	23	22	2	MP:0012725
MousePheno	abnormal Meibomian gland morphology	SCD5 SCD	5.86e-04	23	22	2	MP:0005252
MousePheno	abnormal skin sebaceous gland morphology	SCD5 SCD	6.94e-04	25	22	2	MP:0009535
MousePheno	dry skin	SCD5 SCD	6.94e-04	25	22	2	MP:0003853
MousePheno	parakeratosis	SCD5 SCD	6.94e-04	25	22	2	MP:0003427
MousePheno	decreased skin tensile strength	SCD5 SCD	7.51e-04	26	22	2	MP:0003089
MousePheno	abnormal cutaneous collagen fibril morphology	SCD5 SCD	8.10e-04	27	22	2	MP:0008438
MousePheno	spontaneous skin ulceration	SCD5 SCD	9.36e-04	29	22	2	MP:0001209
MousePheno	prolonged diestrus	SCD5 SCD	1.00e-03	30	22	2	MP:0009011
MousePheno	wrinkled skin	SCD5 SCD	1.07e-03	31	22	2	MP:0001211
MousePheno	abnormal skin tensile strength	SCD5 SCD	1.14e-03	32	22	2	MP:0005275
MousePheno	neonatal lethality	PKHD1 PPME1 LTBP1 BCL11A SCD CSAD	1.16e-03	799	22	6	MP:0002058
MousePheno	abnormal diestrus	SCD5 SCD	1.36e-03	35	22	2	MP:0009010
MousePheno	granulomatous inflammation	SCD5 SCD	1.44e-03	36	22	2	MP:0002500
MousePheno	increased circulating ketone body level	SCD5 SCD	1.69e-03	39	22	2	MP:0002575
MousePheno	decreased hair follicle number	SCD5 SCD	1.87e-03	41	22	2	MP:0000379
MousePheno	ketosis	SCD5 SCD	2.05e-03	43	22	2	MP:0030970
MousePheno	acanthosis	SCD5 SCD	2.05e-03	43	22	2	MP:0001874
MousePheno	epidermis stratum spinosum hyperplasia	SCD5 SCD	2.25e-03	45	22	2	MP:0009611
MousePheno	narrow eye opening	SCD5 SCD	2.77e-03	50	22	2	MP:0005287
MousePheno	increased insulin sensitivity	STRA6 SCD5 SCD	3.05e-03	188	22	3	MP:0002891
MousePheno	abnormal circulating ketone body level	SCD5 SCD	3.22e-03	54	22	2	MP:0003457
MousePheno	abnormal hair follicle development	SCD5 SCD	3.22e-03	54	22	2	MP:0003704
MousePheno	scaly skin	SCD5 SCD	3.34e-03	55	22	2	MP:0001192
MousePheno	abnormal hair cycle	SCD5 SCD	3.34e-03	55	22	2	MP:0000427
Domain	FATTY_ACID_DESATUR_1	SCD5 SCD	2.33e-06	2	29	2	PS00476
Domain	FADS-1_CS	SCD5 SCD	2.33e-06	2	29	2	IPR001522
Domain	Acyl-CoA_DS	SCD5 SCD	2.33e-06	2	29	2	IPR015876
Domain	FA_desaturase_dom	SCD5 SCD	6.48e-05	8	29	2	IPR005804
Domain	FA_desaturase	SCD5 SCD	6.48e-05	8	29	2	PF00487
Pathway	WP_TRANSSULFURATION_PATHWAY	MPST CSAD	6.89e-05	10	18	2	M39324
Pathway	WP_ELONGATION_OF_VERY_LONG_CHAIN_FATTY_ACIDS	SCD5 SCD	1.01e-04	12	18	2	MM17077
Pathway	WP_OMEGA9_FATTY_ACID_SYNTHESIS	SCD5 SCD	1.39e-04	14	18	2	M39780
Pathway	REACTOME_DEGRADATION_OF_CYSTEINE_AND_HOMOCYSTEINE	MPST CSAD	1.60e-04	15	18	2	M26981
Pathway	WP_CYSTEINE_AND_METHIONINE_CATABOLISM	MPST CSAD	1.60e-04	15	18	2	M39790
Pathway	KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS	SCD5 SCD	3.50e-04	22	18	2	M11673
Pathway	WP_FATTY_ACID_BIOSYNTHESIS	SCD5 SCD	3.83e-04	23	18	2	MM15885
Pathway	REACTOME_SULFUR_AMINO_ACID_METABOLISM	MPST CSAD	5.71e-04	28	18	2	M547
Pathway	REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS	SCD5 SCD	9.99e-04	37	18	2	M729
Pathway	REACTOME_FATTY_ACID_METABOLISM	DPEP1 SCD5 SCD	1.36e-03	176	18	3	M27854
Pathway	WP_CHOLESTEROL_METABOLISM_WITH_BLOCH_AND_KANDUTSCHRUSSELL_PATHWAYS	SCD5 SCD	1.97e-03	52	18	2	MM15920
Pathway	REACTOME_REGULATION_OF_CHOLESTEROL_BIOSYNTHESIS_BY_SREBP_SREBF	MBTPS1 SCD	2.20e-03	55	18	2	M27001
Pubmed	Early-life exposure to bisphenol A induces dysregulation of lipid homeostasis by the upregulation of SCD1 in male mice.	SCD5 SCD	6.71e-07	2	29	2	35341816
Pubmed	SCD1 deficiency protects mice against ethanol-induced liver injury.	SCD5 SCD	6.71e-07	2	29	2	27477676
Pubmed	Clofibrate treatment increases stearoyl-CoA desaturase mRNA level and enzyme activity in mouse liver.	SCD5 SCD	6.71e-07	2	29	2	8541340
Pubmed	Polyunsaturated fatty acids do not activate AMP-activated protein kinase in mouse tissues.	SCD5 SCD	6.71e-07	2	29	2	15916750
Pubmed	Skin-specific deletion of stearoyl-CoA desaturase-1 alters skin lipid composition and protects mice from high fat diet-induced obesity.	SCD5 SCD	6.71e-07	2	29	2	19429677
Pubmed	Overexpression of stearoyl-coenzyme A desaturase 1 in macrophages promotes reverse cholesterol transport.	SCD5 SCD	6.71e-07	2	29	2	23747827
Pubmed	Interplay between Thyroid Hormones and Stearoyl-CoA Desaturase 1 in the Regulation of Lipid Metabolism in the Heart.	SCD5 SCD	6.71e-07	2	29	2	33374300
Pubmed	Diet-dependent alterations of hepatic Scd1 expression are accompanied by differences in promoter methylation.	SCD5 SCD	6.71e-07	2	29	2	23803969
Pubmed	Stearoyl-CoA Desaturase 1 Is a Key Determinant of Membrane Lipid Composition in 3T3-L1 Adipocytes.	SCD5 SCD	6.71e-07	2	29	2	27632198
Pubmed	Obesity resistance of the stearoyl-CoA desaturase-deficient (scd1-/-) mouse results from disruption of the epidermal lipid barrier and adaptive thermoregulation.	SCD5 SCD	6.71e-07	2	29	2	17391062
Pubmed	Increased hydrophilic plasma bile acids are correlated with protection from adiposity in skin-specific stearoyl-CoA desaturase-1 deficient mice.	SCD5 SCD	6.71e-07	2	29	2	29965978
Pubmed	Effects of CRISPR/Cas9-mediated stearoyl-Coenzyme A desaturase 1 knockout on mouse embryo development and lipid synthesis.	SCD5 SCD	6.71e-07	2	29	2	36124130
Pubmed	[Role of stearoyl-CoA desaturase in regulation of energy metabolism].	SCD5 SCD	6.71e-07	2	29	2	18788462
Pubmed	Lack of stearoyl-CoA desaturase-1 function induces a palmitoyl-CoA Delta6 desaturase and represses the stearoyl-CoA desaturase-3 gene in the preputial glands of the mouse.	SCD5 SCD	6.71e-07	2	29	2	12454277
Pubmed	Reduced SCD1 activity alters markers of fatty acid reesterification, glyceroneogenesis, and lipolysis in murine white adipose tissue and 3T3-L1 adipocytes.	SCD5 SCD	6.71e-07	2	29	2	28659287
Pubmed	beta-Adrenergic control of stearoyl-CoA desaturase 1 repression in relation to sympathoadrenal regulation of thermogenesis.	SCD5 SCD	6.71e-07	2	29	2	16801925
Pubmed	Reduced levels of SCD1 accentuate palmitate-induced stress in insulin-producing β-cells.	SCD5 SCD	6.71e-07	2	29	2	20920255
Pubmed	Polyunsaturated fatty acids inhibit hepatic stearoyl-CoA desaturase-1 gene in diabetic mice.	SCD5 SCD	6.71e-07	2	29	2	8729090
Pubmed	Stearoyl-CoA desaturase 1 activity is required for autophagosome formation.	SCD5 SCD	6.71e-07	2	29	2	25023287
Pubmed	Compensatory increases in tear volume and mucin levels associated with meibomian gland dysfunction caused by stearoyl-CoA desaturase-1 deficiency.	SCD5 SCD	6.71e-07	2	29	2	29463801
Pubmed	Scd1 is expressed in sebaceous glands and is disrupted in the asebia mouse.	SCD5 SCD	6.71e-07	2	29	2	10545940
Pubmed	Stearoyl-CoA desaturase regulates inflammatory gene expression by changing DNA methylation level in 3T3 adipocytes.	SCD5 SCD	6.71e-07	2	29	2	25130896
Pubmed	Combined deletion of SCD1 from adipose tissue and liver does not protect mice from obesity.	SCD5 SCD	6.71e-07	2	29	2	22669918
Pubmed	Discovery of potent and liver-selective stearoyl-CoA desaturase (SCD) inhibitors in an acyclic linker series.	SCD5 SCD	6.71e-07	2	29	2	22101133
Pubmed	Compartmentalization of stearoyl-coenzyme A desaturase 1 activity in HepG2 cells.	SCD5 SCD	6.71e-07	2	29	2	18599738
Pubmed	Hereditary Absence of Sebaceous Glands in the Mouse.	SCD5 SCD	6.71e-07	2	29	2	17738154
Pubmed	Metabolic changes in skin caused by Scd1 deficiency: a focus on retinol metabolism.	SCD5 SCD	6.71e-07	2	29	2	21573029
Pubmed	Characterization of human SCD2, an oligomeric desaturase with improved stability and enzyme activity by cross-linking in intact cells.	SCD5 SCD	6.71e-07	2	29	2	15610069
Pubmed	Characterization of HSCD5, a novel human stearoyl-CoA desaturase unique to primates.	SCD5 SCD	6.71e-07	2	29	2	15907797
Pubmed	Stearoyl-CoA Desaturase Regulates Angiogenesis and Energy Metabolism in Ischemic Cardiomyocytes.	SCD5 SCD	6.71e-07	2	29	2	36142371
Pubmed	Structure and Mechanism of a Unique Diiron Center in Mammalian Stearoyl-CoA Desaturase.	SCD5 SCD	6.71e-07	2	29	2	32470559
Pubmed	Nuclear factor 1 is essential for the expression of stearoyl-CoA desaturase 1 gene during preadipocyte differentiation.	SCD5 SCD	6.71e-07	2	29	2	9689914
Pubmed	Stearoyl-CoA desaturase 1 deficiency increases insulin signaling and glycogen accumulation in brown adipose tissue.	SCD5 SCD	6.71e-07	2	29	2	15494611
Pubmed	Role of stearoyl-CoA desaturase-1 in skeletal muscle function and metabolism.	SCD5 SCD	6.71e-07	2	29	2	23941875
Pubmed	Hepatic lipid partitioning and liver damage in nonalcoholic fatty liver disease: role of stearoyl-CoA desaturase.	SCD5 SCD	6.71e-07	2	29	2	19119140
Pubmed	Sebaceous Gland Atrophy in Psoriasis: An Explanation for Psoriatic Alopecia?	SCD5 SCD	6.71e-07	2	29	2	27312025
Pubmed	Absence of stearoyl-CoA desaturase-1 does not promote DSS-induced acute colitis.	SCD5 SCD	6.71e-07	2	29	2	19695343
Pubmed	Dietary fat is a lipid source in 2,3,7,8-tetrachlorodibenzo-ρ-dioxin (TCDD)-elicited hepatic steatosis in C57BL/6 mice.	SCD5 SCD	6.71e-07	2	29	2	22539624
Pubmed	Elevated stearoyl-CoA desaturase in brains of patients with Alzheimer's disease.	SCD5 SCD	6.71e-07	2	29	2	22046234
Pubmed	Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity.	SCD5 SCD	6.71e-07	2	29	2	12177411
Pubmed	Stearoyl CoA Desaturase Is Essential for Regulation of Endoplasmic Reticulum Homeostasis and Tumor Growth in Glioblastoma Cancer Stem Cells.	SCD5 SCD	6.71e-07	2	29	2	30930246
Pubmed	Scd1ab-Xyk: a new asebia allele characterized by a CCC trinucleotide insertion in exon 5 of the stearoyl-CoA desaturase 1 gene in mouse.	SCD5 SCD	6.71e-07	2	29	2	15278437
Pubmed	Dietary regulation of stearoyl-CoA desaturase 1 gene expression in mouse liver.	SCD5 SCD	6.71e-07	2	29	2	1350282
Pubmed	Loss of Stearoyl-CoA desaturase-1 attenuates adipocyte inflammation: effects of adipocyte-derived oleate.	SCD5 SCD	6.71e-07	2	29	2	19910642
Pubmed	The expression of the gene asebia in the laboratory mouse. I. Epidermis and dermis.	SCD5 SCD	6.71e-07	2	29	2	631559
Pubmed	Dyslipidemia and atherosclerosis induced by chronic intermittent hypoxia are attenuated by deficiency of stearoyl coenzyme A desaturase.	SCD5 SCD	6.71e-07	2	29	2	18832746
Pubmed	Differentiation-induced gene expression in 3T3-L1 preadipocytes. Characterization of a differentially expressed gene encoding stearoyl-CoA desaturase.	SCD5 SCD	6.71e-07	2	29	2	2903162
Pubmed	SCD1 is nutritionally and spatially regulated in the intestine and influences systemic postprandial lipid homeostasis and gut-liver crosstalk.	SCD5 SCD	6.71e-07	2	29	2	35718096
Pubmed	Stearoyl-CoA desaturase 1 deficiency protects mice from immune-mediated liver injury.	SCD5 SCD	6.71e-07	2	29	2	19002112
Pubmed	Deletion of Stearoyl-CoA Desaturase-1 From the Intestinal Epithelium Promotes Inflammation and Tumorigenesis, Reversed by Dietary Oleate.	SCD5 SCD	6.71e-07	2	29	2	30063922
Pubmed	Aberrant lipid metabolism in anaplastic thyroid carcinoma reveals stearoyl CoA desaturase 1 as a novel therapeutic target.	SCD5 SCD	6.71e-07	2	29	2	25675381
Pubmed	Targeted disruption of stearoyl-CoA desaturase1 gene in mice causes atrophy of sebaceous and meibomian glands and depletion of wax esters in the eyelid.	SCD5 SCD	6.71e-07	2	29	2	11533264
Pubmed	Glycerol regulates stratum corneum hydration in sebaceous gland deficient (asebia) mice.	SCD5 SCD	6.71e-07	2	29	2	12713573
Pubmed	Stearoyl-CoA Desaturase Promotes Liver Fibrosis and Tumor Development in Mice via a Wnt Positive-Signaling Loop by Stabilization of Low-Density Lipoprotein-Receptor-Related Proteins 5 and 6.	SCD5 SCD	6.71e-07	2	29	2	28143772
Pubmed	Cholestasis and hypercholesterolemia in SCD1-deficient mice fed a low-fat, high-carbohydrate diet.	SCD5 SCD	6.71e-07	2	29	2	17005996
Pubmed	Hepatic stearoyl-CoA desaturase-1 deficiency protects mice from carbohydrate-induced adiposity and hepatic steatosis.	SCD5 SCD	6.71e-07	2	29	2	18054317
Pubmed	Role of stearoyl-CoA desaturase-1 in skin integrity and whole body energy balance.	SCD5 SCD	6.71e-07	2	29	2	24356954
Pubmed	Skin lipids of a normal and mutant (asebic) mouse strain.	SCD5 SCD	6.71e-07	2	29	2	5924301
Pubmed	Membrane topology of mouse stearoyl-CoA desaturase 1.	SCD5 SCD	6.71e-07	2	29	2	16275639
Pubmed	Liver X receptor agonist TO-901317 upregulates SCD1 expression in renal proximal straight tubule.	SCD5 SCD	6.71e-07	2	29	2	16368743
Pubmed	SCD1 promotes lipid mobilization in subcutaneous white adipose tissue.	SCD5 SCD	6.71e-07	2	29	2	32978274
Pubmed	Stearoyl-CoA desaturase 1 (Scd1) gene overexpression is associated with genetic predisposition to hepatocarcinogenesis in mice and rats.	SCD5 SCD	6.71e-07	2	29	2	12419843
Pubmed	Lack of stearoyl-CoA desaturase 1 upregulates basal thermogenesis but causes hypothermia in a cold environment.	SCD5 SCD	6.71e-07	2	29	2	15210843
Pubmed	Positive association of SCD1 genetic variation and metabolic syndrome in dialysis patients in China.	SCD5 SCD	6.71e-07	2	29	2	32125933
Pubmed	Inhibition of stearoyl-CoA desaturase-1 in differentiating 3T3-L1 preadipocytes upregulates elongase 6 and downregulates genes affecting triacylglycerol synthesis.	SCD5 SCD	6.71e-07	2	29	2	24566853
Pubmed	cDNA nucleotide sequence coding for stearoyl-CoA desaturase and its expression in the zebrafish (Danio rerio) embryo.	SCD5 SCD	6.71e-07	2	29	2	14579408
Pubmed	Stearoyl-CoA desaturase 1 deficiency elevates insulin-signaling components and down-regulates protein-tyrosine phosphatase 1B in muscle.	SCD5 SCD	6.71e-07	2	29	2	12960377
Pubmed	The biosynthesis of hepatic cholesterol esters and triglycerides is impaired in mice with a disruption of the gene for stearoyl-CoA desaturase 1.	SCD5 SCD	6.71e-07	2	29	2	10899171
Pubmed	Susceptibility of podocytes to palmitic acid is regulated by stearoyl-CoA desaturases 1 and 2.	SCD5 SCD	6.71e-07	2	29	2	23867797
Pubmed	Liver gene expression analysis reveals endoplasmic reticulum stress and metabolic dysfunction in SCD1-deficient mice fed a very low-fat diet.	SCD5 SCD	6.71e-07	2	29	2	18381840
Pubmed	Metabolomics reveals that hepatic stearoyl-CoA desaturase 1 downregulation exacerbates inflammation and acute colitis.	SCD5 SCD	6.71e-07	2	29	2	18249173
Pubmed	Altered fatty acid metabolism and reduced stearoyl-coenzyme a desaturase activity in asthma.	SCD5 SCD	6.71e-07	2	29	2	28397284
Pubmed	Identification of a novel SCD gene and expression of the SCD gene family in mouse skin.	SCD5 SCD	6.71e-07	2	29	2	10674390
Pubmed	Mice fed a lipogenic methionine-choline-deficient diet develop hypermetabolism coincident with hepatic suppression of SCD-1.	SCD5 SCD	6.71e-07	2	29	2	16829692
Pubmed	Differential expression of hepatic stearoyl-CoA desaturase gene 1 in male and female mice.	SCD5 SCD	6.71e-07	2	29	2	8954132
Pubmed	Overexpression of stearoyl-CoA desaturase 1 in bone-marrow mesenchymal stem cells increases osteogenesis.	SCD5 SCD	6.71e-07	2	29	2	24088802
Pubmed	Dietary cholesterol opposes PUFA-mediated repression of the stearoyl-CoA desaturase-1 gene by SREBP-1 independent mechanism.	SCD5 SCD	6.71e-07	2	29	2	12364560
Pubmed	Stearoly-CoA desaturase 1 differentiates early and advanced dengue virus infections and determines virus particle infectivity.	SCD5 SCD	6.71e-07	2	29	2	30118512
Pubmed	Hepatic oleate regulates adipose tissue lipogenesis and fatty acid oxidation.	SCD5 SCD	6.71e-07	2	29	2	25555387
Pubmed	Stearoyl CoA desaturase is required to produce active, lipid-modified Wnt proteins.	SCD5 SCD	6.71e-07	2	29	2	24055053
Pubmed	Asebia-2J (Scd1(ab2J)): a new allele and a model for scarring alopecia.	SCD5 SCD	6.71e-07	2	29	2	10854228
Pubmed	Diet-induced changes in stearoyl-CoA desaturase 1 expression in obesity-prone and -resistant mice.	SCD5 SCD	6.71e-07	2	29	2	15340109
Pubmed	Stearoyl-CoA desaturase-1 mediates the pro-lipogenic effects of dietary saturated fat.	SCD5 SCD	6.71e-07	2	29	2	17127673
Pubmed	A lipogenic diet in mice with a disruption of the stearoyl-CoA desaturase 1 gene reveals a stringent requirement of endogenous monounsaturated fatty acids for triglyceride synthesis.	SCD5 SCD	6.71e-07	2	29	2	11441127
Pubmed	Loss of stearoyl-CoA desaturase activity leads to free cholesterol synthesis through increased Xbp-1 splicing.	SCD5 SCD	6.71e-07	2	29	2	20923962
Pubmed	SCD1 inhibition during 3T3-L1 adipocyte differentiation remodels triacylglycerol, diacylglycerol and phospholipid fatty acid composition.	SCD5 SCD	6.71e-07	2	29	2	25959085
Pubmed	Lipid level and type alter stearoyl CoA desaturase mRNA abundance differently in mice with distinct susceptibilities to diet-influenced diseases.	SCD5 SCD	6.71e-07	2	29	2	9109606
Pubmed	Metabolic rerouting via SCD1 induction impacts X-linked adrenoleukodystrophy.	SCD5 SCD	6.71e-07	2	29	2	33690217
Pubmed	Systemic down-regulation of delta-9 desaturase promotes muscle oxidative metabolism and accelerates muscle function recovery following nerve injury.	SCD5 SCD	6.71e-07	2	29	2	23785402
Pubmed	Stearoyl-CoA Desaturase-1 Protects Cells against Lipotoxicity-Mediated Apoptosis in Proximal Tubular Cells.	SCD5 SCD	6.71e-07	2	29	2	27834856
Pubmed	Hair Growth Cycle Is Arrested in SCD1 Deficiency by Impaired Wnt3a-Palmitoleoylation and Retrieved by the Artificial Lipid Barrier.	SCD5 SCD	6.71e-07	2	29	2	28259688
Pubmed	Loss of stearoyl-CoA desaturase 1 inhibits fatty acid oxidation and increases glucose utilization in the heart.	SCD5 SCD	6.71e-07	2	29	2	18042664
Pubmed	Stearoyl-CoA Desaturase-2 in Murine Development, Metabolism, and Disease.	SCD5 SCD	6.71e-07	2	29	2	33207603
Pubmed	Dynamic role of Scd1 gene during mouse oocyte growth and maturation.	SCD5 SCD	6.71e-07	2	29	2	37315672
Pubmed	Human stearoyl-CoA desaturase 1 (SCD-1) gene expression is negatively regulated by thyroid hormone without direct binding of thyroid hormone receptor to the gene promoter.	SCD5 SCD	6.71e-07	2	29	2	23221600
Pubmed	Biochemical and physiological function of stearoyl-CoA desaturase.	SCD5 SCD	6.71e-07	2	29	2	19066317
Pubmed	Lung fibroblasts promote metastatic colonization through upregulation of stearoyl-CoA desaturase 1 in tumor cells.	SCD5 SCD	6.71e-07	2	29	2	29326439
Pubmed	Alpha-linolenic acid increases cholesterol efflux in macrophage-derived foam cells by decreasing stearoyl CoA desaturase 1 expression: evidence for a farnesoid-X-receptor mechanism of action.	SCD5 SCD	6.71e-07	2	29	2	21658928
Pubmed	Regulation of stearoyl-CoA desaturase by polyunsaturated fatty acids and cholesterol.	SCD5 SCD	6.71e-07	2	29	2	10484602
Pubmed	SCD1 promotes the stemness of gastric cancer stem cells by inhibiting ferroptosis through the SQLE/cholesterol/mTOR signalling pathway.	SCD5 SCD	6.71e-07	2	29	2	38972654
Cytoband	22q13.1	MPST CACNA1I	1.33e-03	85	29	2	22q13.1
Cytoband	Ensembl 112 genes in cytogenetic band chr16q24	DPEP1 MBTPS1	3.36e-03	136	29	2	chr16q24
GeneFamily	Fatty acid desaturases	SCD5 SCD	1.79e-05	8	15	2	553
ToppCell	droplet-Lung-nan-3m-Lymphocytic-Zbtb32+_B\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1I BCL11A RPS6KL1 SCD	3.25e-06	158	29	4	66c011e9de002224f70725dfe8e7871c8d304492
ToppCell	facs-Heart-RA-24m-Lymphocytic-B_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC39A4 CACNA1I BCL11A SCD	3.86e-06	165	29	4	36415924d05373e9dd3665be599f4f3f40bf0497
ToppCell	facs-Heart-RA-24m-Lymphocytic-B_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC39A4 CACNA1I BCL11A SCD	3.86e-06	165	29	4	56310fddd3d8e4afdfde066d26cee9747e5b8c6a
ToppCell	Goblet-gob-2\|World / Class top	BCL11A MAMDC4 PGAP6	1.06e-04	142	29	3	9b058dc313d1f0edcd8473e342852632e17536a6
ToppCell	droplet-Lung-3m-Hematologic-lymphocytic-Zbtb32+_B_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CACNA1I BCL11A SCD	1.53e-04	161	29	3	98be0cf8228496b31f7f3e0efd8787e95eb626d1
ToppCell	facs-Mammary_Gland-Mammary_Gland-18m-Epithelial-nan\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC39A4 LTBP1 BCL11A	1.53e-04	161	29	3	b9a63fc9becc44d305fc7c221283bf59ec06b10f
ToppCell	droplet-Lung-3m-Hematologic-lymphocytic-Zbtb32+_B_cell-Zbtb32+_B_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CACNA1I BCL11A SCD	1.53e-04	161	29	3	7af3b0d4fc7967f6b3e2d255d23fd8b1fd01a7af
ToppCell	facs-Large_Intestine-Proximal-24m-Epithelial-enterocyte_of_epithelium_of_large_intestine\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MPST DPEP1 SLC39A4	1.62e-04	164	29	3	2a00515d91ea03efcfc2a3d3c805dc2711867fcd
ToppCell	facs-Large_Intestine-Proximal-24m-Epithelial-Enterocyte_(Proximal)\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MPST DPEP1 SLC39A4	1.65e-04	165	29	3	ce79d217df88035457cd58f679e72dd98722ae22
ToppCell	droplet-Lung-nan-18m-Lymphocytic-Zbtb32+_B\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1I BCL11A SCD	1.68e-04	166	29	3	3e3e9296e6919a38602e417a6606c046af3bd101
ToppCell	facs-Kidney-nan-3m-Lymphocytic-B_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1I BCL11A MAMDC4	1.68e-04	166	29	3	6a948aefd283a2572da37b59dbc142b6e686b024
ToppCell	facs-Kidney-nan-3m-Lymphocytic-B_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1I BCL11A MAMDC4	1.68e-04	166	29	3	8d0c4eb90a2c006f96ae61d3d94c96fb64bc0c4d
ToppCell	droplet-Kidney-nan-18m-Epithelial-Epcam____brush_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MPST SCD CSAD	1.71e-04	167	29	3	ed7e785dcd25777f64e0c2596ada4f5a5ea17121
ToppCell	facs-Lung-EPCAM-24m-Lymphocytic-B_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1I BCL11A SCD	1.71e-04	167	29	3	691f3589de0f8c13f9137812cfa9040c07d237b4
ToppCell	severe-Myeloid-mDC\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	BCL11A ZBED3 RPS6KL1	1.74e-04	168	29	3	eff37a92d41624924201372cc09f9eb07b60aec1
ToppCell	droplet-Kidney-nan-18m-Epithelial-brush_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MPST SCD CSAD	1.77e-04	169	29	3	f00741203efa0b948db7223ee8c19bdd0918258a
ToppCell	droplet-Kidney-nan-21m-Epithelial-brush_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MPST SCD CSAD	1.83e-04	171	29	3	007f148f4611ea1826edfa9f91ced36541ad9f5a
ToppCell	droplet-Kidney-nan-21m-Epithelial-Epcam____brush_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MPST SCD CSAD	1.83e-04	171	29	3	8e7223ba447947cdf4e1c82a52fd90439cf3d8f6
ToppCell	droplet-Heart-HEART-1m-Endothelial-leukocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC39A4 STRA6 RPS6KL1	1.90e-04	173	29	3	9dc7746a84f0e268a7c061e1bbcd5e31903034dc
ToppCell	facs-Marrow-T-cells-24m-Lymphocytic-naive_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DPEP1 SLC39A4 SCD	1.93e-04	174	29	3	9f7b983459d47b12a1b64e17e29b85a6ff4dc258
ToppCell	facs-Marrow-T-cells-24m-Lymphocytic-naive_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DPEP1 SLC39A4 SCD	1.93e-04	174	29	3	ba909e8789a62968e90bc1c4ab614de738c130f7
ToppCell	356C-Lymphocytic-NK_cells-NK_cell_E\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	SCD5 MAMDC4 RNF212	1.93e-04	174	29	3	a79ebb01a5849c314e02594a9c95009dbb03cb8c
ToppCell	facs-Kidney-nan-18m-Epithelial-epithelial_cell_of_proximal_tubule\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MPST SCD CSAD	1.96e-04	175	29	3	076ad81d6cbeea5512393d192af3ab5aa1f82975
ToppCell	facs-Kidney-nan-18m-Epithelial-epithelial_cell_of_proximal_tubule\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MPST SCD CSAD	1.96e-04	175	29	3	445ccb9744a3a9ff37164c532afbe769d306b6c8
ToppCell	facs-Lung-24m-Hematologic-lymphocytic-B_cell-B_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CACNA1I BCL11A SCD	2.00e-04	176	29	3	27c132e9852717cbc345af7a1fc390e9ea589416
ToppCell	droplet-Large_Intestine-COLON_-_"PROM_Tm"\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MPST DPEP1 SCD	2.00e-04	176	29	3	3c3b6c02d7acdc1305878ee34e9cbabbf9e87892
ToppCell	droplet-Large_Intestine-COLON_-_"PROM_Tm"-30m\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MPST DPEP1 SCD	2.00e-04	176	29	3	7c743b7e954c1ebfa289ed529abacb88504112ea
ToppCell	droplet-Large_Intestine-COLON_-_"PROM_Tm"-30m-Epithelial-Enterocyte\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MPST DPEP1 SCD	2.00e-04	176	29	3	ce950805aaa3d39630376028ecd7da584fdb4394
ToppCell	facs-Heart-LA-24m-Lymphocytic-B_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1I BCL11A SCD	2.00e-04	176	29	3	fc2ba468677b19b55130c1f06737f40300cd9d2e
ToppCell	facs-Heart-LA-24m-Lymphocytic-B_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1I BCL11A SCD	2.00e-04	176	29	3	077f3fe5e3482ea3f639d789bd3d584161b36c02
ToppCell	droplet-Large_Intestine-COLON_-_"PROM_Tm"-30m-Epithelial-enterocyte_of_epithelium_of_large_intestine\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MPST DPEP1 SCD	2.00e-04	176	29	3	5b65693833e02c08530488cbe37883e7c75f312e
ToppCell	facs-Lung-24m-Hematologic-lymphocytic-B_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CACNA1I BCL11A SCD	2.00e-04	176	29	3	259d1864fb0a6d2feddc90bc715e2bccbb373792
ToppCell	facs-Lung-ENDOMUCIN-18m-Lymphocytic-B_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1I BCL11A SCD	2.06e-04	178	29	3	ba5a477257877f4a15a91c1762ffcc6f2e9f7357
ToppCell	facs-Lung-ENDOMUCIN-18m-Lymphocytic-B_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1I BCL11A SCD	2.06e-04	178	29	3	5634c1fbc817758092af4feafff94d107412d89b
ToppCell	facs-GAT-Fat-3m-Lymphocytic-B_cell\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1I BCL11A SCD	2.06e-04	178	29	3	5b6f7e8a930c239db1f31edfb61b2b9228d28663
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SCD5 PGAP6 RNF212	2.10e-04	179	29	3	d0fa700648db8ce76a8aa689879a25048299fa40
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SCD5 PGAP6 RNF212	2.10e-04	179	29	3	2e49b215b71438400aebb483f2c2c08d5e956961
ToppCell	facs-MAT-Fat-24m-Lymphocytic-B_cell\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1I BCL11A SCD	2.13e-04	180	29	3	711719219bcbafdd505790eda895e7a33f21bed2
ToppCell	droplet-Lung-nan-21m-Lymphocytic-B_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1I BCL11A SCD	2.13e-04	180	29	3	b673d11d764e275883fc5edbad97137a6549df6a
ToppCell	droplet-Large_Intestine-COLON_-_"PROM_Tm"-30m-Epithelial\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MPST DPEP1 SCD	2.17e-04	181	29	3	a52e367f0909689174b3534f0cd51f36abe1b49f
ToppCell	droplet-Lung-LUNG-30m-Lymphocytic-B_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1I BCL11A SCD	2.17e-04	181	29	3	46de8c18e4ec8dc9d07f7c8cc7b5f48b9c613aae
ToppCell	facs-Lung-EPCAM-18m-Lymphocytic-B_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1I BCL11A SCD	2.17e-04	181	29	3	2c2b812cdd350271935d7007665c26093756ebee
ToppCell	droplet-Lung-30m-Hematologic-lymphocytic-B_cell\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CACNA1I BCL11A SCD	2.17e-04	181	29	3	477c572c5c1efceee49732cc9e8b1dad68a7e6e5
ToppCell	droplet-Lung-30m-Hematologic-lymphocytic-B_cell-B_cell\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CACNA1I BCL11A SCD	2.17e-04	181	29	3	909280b44085d8e96fcd3cbcba6bff94badd41e8
ToppCell	droplet-Thymus-nan-24m-Myeloid-nan\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DPEP1 BCL11A SCD	2.17e-04	181	29	3	2a3092fbadd18967199f1203c11f0dd956417254
ToppCell	facs-Lung-EPCAM-18m-Lymphocytic-B_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1I BCL11A SCD	2.17e-04	181	29	3	ce30724788d9b5c6dfa4f9f8d318c3d2565165ed
ToppCell	facs-Lung-EPCAM-24m-Lymphocytic-B_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1I BCL11A SCD	2.24e-04	183	29	3	1614704fe0d8cd4c54c49f93f0cefb790ca897c7
ToppCell	LA-11._Adipocyte\|World / Chamber and Cluster_Paper	ZBED3 SCD CSAD	2.24e-04	183	29	3	b177be283e1553fb1f69a346f1ba79ad00297fa2
ToppCell	LA-11._Adipocyte\|LA / Chamber and Cluster_Paper	ZBED3 SCD CSAD	2.24e-04	183	29	3	3f9011976782fa8aa95cdd6f00f07a91094d411b
ToppCell	facs-Lung-18m-Hematologic-lymphocytic-B_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CACNA1I BCL11A SCD	2.27e-04	184	29	3	eb41dce59eb0384c1671fbc76eb15daab2c8c49a
ToppCell	facs-Lung-18m-Hematologic-lymphocytic-B_cell-B_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CACNA1I BCL11A SCD	2.27e-04	184	29	3	991500a874c5dd0d9111399520071da67bc6ac3d
ToppCell	facs-GAT-Fat-18m-Lymphocytic-B_cell\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1I BCL11A SCD	2.31e-04	185	29	3	1eba3b058e23a7d19024b4363dfeb522a8af313d
ToppCell	droplet-Lung-nan-18m-Lymphocytic-B_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1I BCL11A SCD	2.31e-04	185	29	3	d4076294571557c223f5b68244e9c53e1d8f0343
ToppCell	droplet-Mammary_Gland-nan-18m-Lymphocytic-B_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1I BCL11A SCD	2.35e-04	186	29	3	124a618a0911aba9fc2a071dc3ca40fc003bb1ed
ToppCell	facs-SCAT-Fat-3m-Lymphocytic-B_cell\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1I BCL11A SCD	2.35e-04	186	29	3	d5d990d8b6ccd8ca8fe7d0d7dedbe2359ae7b582
ToppCell	droplet-Fat-BAT+GAT+MAT-30m-Lymphocytic-B_cell\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1I BCL11A SCD	2.35e-04	186	29	3	0018a949f9f5bfc17f823601303f04dfd56c9a38
ToppCell	droplet-Lung-nan-18m-Lymphocytic-B_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1I BCL11A SCD	2.35e-04	186	29	3	683f59985fbc5d3ba2412c788b4647dbbf42699a
ToppCell	pdx-Tumor_cells-T5\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	DPEP1 CACNA1I STRA6	2.38e-04	187	29	3	7e376831a11ee72ed87abcdac631ca46ae29c250
ToppCell	facs-Spleen-nan-3m-Lymphocytic-CD79a_B_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DPEP1 BCL11A SCD	2.38e-04	187	29	3	b51af2824e65734f333b1325117f4a2e88b17c23
ToppCell	facs-Spleen-nan-3m-Lymphocytic-B_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DPEP1 BCL11A SCD	2.38e-04	187	29	3	3ca3954f45f167e98a230f2847f0582d74fcd32e
ToppCell	facs-Lung-3m-Hematologic-lymphocytic-B_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CACNA1I BCL11A SCD	2.38e-04	187	29	3	57f9c9162694c184a8fd6634ee0fad511ca71c9e
ToppCell	facs-Lung-3m-Hematologic-lymphocytic-B_cell-B_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CACNA1I BCL11A SCD	2.38e-04	187	29	3	6ce6d3678026101c4397320430433c9f05740883
ToppCell	facs-Marrow-T-cells-3m-Lymphocytic-naive_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1I BCL11A SCD	2.42e-04	188	29	3	1f07e3ab87173426fe0c429f5c084fb3425effd3
ToppCell	facs-Marrow-T-cells-3m-Lymphocytic-naive_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1I BCL11A SCD	2.42e-04	188	29	3	85746f95319e494efdc1bbc24331698688d3a900
ToppCell	droplet-Lung-nan-21m-Lymphocytic-B_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1I BCL11A SCD	2.50e-04	190	29	3	046de398870b6d483466f369813b100c22743301
ToppCell	droplet-Lung-1m-Hematologic-lymphocytic-B_cell\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CACNA1I BCL11A SCD	2.54e-04	191	29	3	6729b71fb674aea770a4a3167ccfc07acbf9f302
ToppCell	droplet-Lung-1m-Hematologic-lymphocytic-B_cell-B_cell\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CACNA1I BCL11A SCD	2.54e-04	191	29	3	f9fed8dbc4e4e34e59d8c4154e4e3fb320b12257
ToppCell	droplet-Lung-21m-Hematologic-lymphocytic-B_cell\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CACNA1I BCL11A SCD	2.58e-04	192	29	3	b0686c0676f7658b560967840adb6c182792b075
ToppCell	severe-Others-CD34+_GATA2+_cells\|Others / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	BCL11A ZBED3 SCD	2.58e-04	192	29	3	2e80755627d0350be8976324329e106e808d5574
ToppCell	droplet-Lung-21m-Hematologic-lymphocytic-B_cell-B_cell\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CACNA1I BCL11A SCD	2.58e-04	192	29	3	7e626ec5a4615e7e04a324937d5f0147dd17ca8e
ToppCell	droplet-Lung-18m-Hematologic-lymphocytic-B_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CACNA1I BCL11A SCD	2.62e-04	193	29	3	a808eb426b4ce9ddf7d6556b083abd9232a218b1
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DPEP1 LTBP1 SCD	2.62e-04	193	29	3	0a665531d581d4e3941e29d3f95569da8f166447
ToppCell	droplet-Lung-18m-Hematologic-lymphocytic-B_cell-B_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CACNA1I BCL11A SCD	2.62e-04	193	29	3	e1d0b2d2d6b65d32922e22d092848ac4200669d5
ToppCell	facs-Trachea-18m-Mesenchymal-fibroblast\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DPEP1 LTBP1 SCD	2.62e-04	193	29	3	25248b8e65d558b1a96a87c93e3e5b4c0ba168fe
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Mesenchymal-fibroblast\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DPEP1 LTBP1 SCD	2.62e-04	193	29	3	24ce1f37cca655415410d2403a52d1ebb3332280
ToppCell	facs-Trachea-18m-Mesenchymal-fibroblast-fibroblast_of_trachea\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DPEP1 LTBP1 SCD	2.62e-04	193	29	3	f1f1097204e07a7bed416425b8256942038a734f
ToppCell	3'-Child04-06-SmallIntestine-Mesenchymal-stromal_related-FDC\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LTBP1 STRA6 RPS6KL1	2.66e-04	194	29	3	f9fbb043411546d8c9e0321a64165d411f44aeb7
ToppCell	(3)_Chondrocytes-(33)_Chondro-prol/rest\|(3)_Chondrocytes / Cell class and subclass of bone marrow stroma cells in homeostatis	NDC1 SCD5 SCD	2.66e-04	194	29	3	4a207630d72059345b10010f5cfd3b1462458324
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Mesenchymal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DPEP1 LTBP1 SCD	2.66e-04	194	29	3	2d0cff9dc538a14518741e2a96d9d78442c81a72
ToppCell	5'-GW_trimst-2-LargeIntestine-Epithelial-mature_enterocytic-Enterocyte\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DPEP1 SLC39A4 MAMDC4	2.66e-04	194	29	3	fcbf9c4f3801ab1a34fcd62c752fabc97fc7bde1
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-2M-Neuronal-cortical_neurons_1\|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.	BCL11A RPS6KL1 CSAD	2.82e-04	198	29	3	d81f35c0066558ff96dd06f58fca72cd82e681e8
ToppCell	3'-Child09-12-SmallIntestine-Epithelial-mature_enterocytic\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MPST DPEP1 SLC39A4	2.82e-04	198	29	3	222a060c2c63d30da34e4b71c37aa27a048d7d09
ToppCell	Brain_organoid-organoid_Velasco_nature-3_mon-Neuronal\|3_mon / Sample Type, Dataset, Time_group, and Cell type.	BCL11A SCD5 RPS6KL1	2.82e-04	198	29	3	a0032e3ed259e39324a659490b9d340c5d9ba0fc
ToppCell	3'-Child04-06-SmallIntestine-Epithelial-mature_enterocytic-Enterocyte\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MPST DPEP1 SLC39A4	2.86e-04	199	29	3	0181c13379f869be47804cdb11bbdabcd30b9b23
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-3.5_mon-Neuronal\|3.5_mon / Sample Type, Dataset, Time_group, and Cell type.	BCL11A SCD5 RPS6KL1	2.86e-04	199	29	3	0cd3e4e0fba000c996feaf012ff32198e1048c9d
ToppCell	5'-GW_trimst-2-SmallIntestine-Epithelial\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DPEP1 SLC39A4 MAMDC4	2.86e-04	199	29	3	914f66e2b4af323d09fa2340a39cf8051d00a422
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_arterial-F\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	DPEP1 EXOC3L1 STRA6	2.86e-04	199	29	3	463ba77dc4c85eebb343f29a42c7ac889b0497c9
ToppCell	3'-Child04-06-SmallIntestine-Epithelial-mature_enterocytic\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MPST DPEP1 SLC39A4	2.86e-04	199	29	3	ee981046217e8759610eb58a670d98f32cd83abc
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW10-Neuronal\|GW10 / Sample Type, Dataset, Time_group, and Cell type.	BCL11A SCD5 RPS6KL1	2.90e-04	200	29	3	04699d1149a143b96d6f292c0d70c4d3e6dfc611
ToppCell	5'-GW_trimst-2-SmallIntestine-Epithelial-mature_enterocytic-Enterocyte\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DPEP1 SLC39A4 MAMDC4	2.90e-04	200	29	3	3e13c9a4ba99a7dfbf738b0fb63fb54b4dee5897
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-3m-Neuronal-Cortical_neuron\|3m / Sample Type, Dataset, Time_group, and Cell type.	BCL11A SCD5 RPS6KL1	2.90e-04	200	29	3	c248233b004f8ef0bab3c65ecfe295887966f2ee
ToppCell	5'-GW_trimst-2-SmallIntestine-Epithelial-mature_enterocytic\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DPEP1 SLC39A4 MAMDC4	2.90e-04	200	29	3	73bfdf068a8ecbefc1e6afe9686df73658ee042f
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-4M-Neuronal-cortical_neurons_2\|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.	BCL11A RPS6KL1 CSAD	2.90e-04	200	29	3	0cb0755a101ec655359d051d6a8807408d727c55
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-3m-Neuronal\|3m / Sample Type, Dataset, Time_group, and Cell type.	BCL11A SCD5 RPS6KL1	2.90e-04	200	29	3	af99d90070e2933fd2e9512590c6cf3bd6e15539
Drug	I2-15	SCD5 SCD	4.70e-06	3	29	2	CID000013388
Drug	9-hexadecenal	SCD5 SCD	9.38e-06	4	29	2	CID000092066
Drug	16-methylprogesterone	SCD5 SCD	1.56e-05	5	29	2	CID000134874
Drug	1-penten-3-ol	SCD5 SCD	1.56e-05	5	29	2	CID000012020
Drug	methyl sterculate	SCD5 SCD	1.56e-05	5	29	2	CID000115261
Drug	C19:0	SCD5 SCD	2.34e-05	6	29	2	CID000012591
Drug	7-hydroxytestosterone	SCD5 SCD	2.34e-05	6	29	2	CID000065541
Drug	C20:1n-9	SCD5 SCD	3.28e-05	7	29	2	CID000142770
Drug	4,4-dimethyloxazoline	SCD5 SCD	3.28e-05	7	29	2	CID000121630
Drug	sterculic acid	SCD5 SCD	3.28e-05	7	29	2	CID000012921
Drug	AC1L9LQQ	SCD5 GFER SCD	5.19e-05	57	29	3	CID000448224
Drug	1,2-dibromo-1,2-dichloroethane	SCD5 SCD	7.00e-05	10	29	2	CID000079092
Drug	HCNO	SCD5 SCD	1.03e-04	12	29	2	CID000521293
Drug	AC1L1R7G	SCD5 SCD	1.21e-04	13	29	2	CID000008542
Drug	6,9,12-octadecatrienoic acid	CACNA1I SCD5 SCD	1.33e-04	78	29	3	CID000003453
Drug	hydroxybutanone	SCD5 SCD	1.41e-04	14	29	2	CID000521300
Disease	restrictive cardiomyopathy (implicated_via_orthology)	SCD5 SCD	6.73e-05	13	28	2	DOID:397 (implicated_via_orthology)
Disease	venous thromboembolism, response to antineoplastic agent	PKHD1 RIC1	6.96e-04	41	28	2	EFO_0004286, GO_0097327
Disease	body mass index, osteoarthritis	DPEP1 LTBP1	1.21e-03	54	28	2	EFO_0004340, MONDO_0005178
Disease	urate measurement, spine bone mineral density	LTBP1 RIC1	1.39e-03	58	28	2	EFO_0004531, EFO_0007701
Disease	alkaline phosphatase measurement	USP43 DPEP1 SLC39A4 SCD RIC1	2.42e-03	1015	28	5	EFO_0004533
Disease	schizophrenia (is_implicated_in)	CACNA1I BCL11A	2.49e-03	78	28	2	DOID:5419 (is_implicated_in)
Disease	physical activity	PKHD1 RNF212	3.16e-03	88	28	2	EFO_0003940
Disease	cognitive function measurement, self reported educational attainment	PKHD1 CACNA1I BCL11A	4.53e-03	355	28	3	EFO_0004784, EFO_0008354

Protein segments in the cluster

Peptide	Gene	Start	Entry
LSLSAHGGLAWRLGS	MAMDC4	916	Q6UXC1
QLWAHTLHSGLRRSL	EXOC3L1	306	Q86VI1
LESQGLSTLLGHRHW	RIC1	466	Q4ADV7
LLHGGGHSALSWAVF	PPME1	81	Q9Y570
SLSLGSGFWHATGRH	MBTPS1	166	Q14703
LLHWRGLSSPRSAHG	BCL11A	131	Q9H165
LLWAGLLASSAHGRL	LTBP1	11	Q14766
HLSHLLLTHVADAWG	PCED1A	256	Q9H1Q7
THSIWHILLAGSAAL	PGAP6	721	Q9HCN3
GLWLHGLLSFLAALH	C6orf47	216	O95873
HAAALAHGLARSPSW	CACNA1I	2166	Q9P0X4
WGGSVLLSQTHRHLL	CSAD	276	Q9Y600
GASSLHRHWGLLLAS	DPEP1	386	P16444
GAALLLSHIFWTHGD	TAF6L	266	Q9Y6J9
GHHAVSLLDGGLRHW	MPST	121	P25325
SGKLHSHRLLSTEWG	PRELID3B	46	Q9Y3B1
WRGGAHGLSRSHSLS	TMEM184B	376	Q9Y519
AGLWASHADHLLALL	SLC39A4	116	Q6P5W5
ALGVTAGAHRLWSHR	SCD5	86	Q86SK9
LLWSDNVAHSSLHGL	PKHD1	3116	P08F94
AAHLLGSTLSWAHLG	STRA6	171	Q9BX79
HALSGNLTDFHLWAR	ADGRD2	266	Q7Z7M1
ELGRHSWAVLHTLAA	GFER	101	P55789
GFHAGTSALWRHLRS	ZBED3	81	Q96IU2
PHWLLLLAFSSGRHG	RNF212	231	Q495C1
SDHWLLRLGSHAGST	USP43	731	Q70EL4
WSHLLSQAHSRHSGL	RPS6KL1	226	Q9Y6S9
SALGITAGAHRLWSH	SCD	111	O00767
HIWALEGLSHLVAAS	NDC1	561	Q9BTX1