Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	L-proline transmembrane transporter activity	SLC6A7 SLC36A3	4.26e-05	7	29	2	GO:0015193
GeneOntologyMolecularFunction	catalytic activity, acting on DNA	CHD7 TOP1MT ARID1A EXD2	5.31e-04	262	29	4	GO:0140097
GeneOntologyMolecularFunction	solute:monoatomic cation symporter activity	SLC6A7 SLC36A3 SLC12A5	6.73e-04	119	29	3	GO:0015294
GeneOntologyMolecularFunction	amino acid:monoatomic cation symporter activity	SLC6A7 SLC36A3	8.07e-04	29	29	2	GO:0005416
GeneOntologyMolecularFunction	ATP-dependent chromatin remodeler activity	CHD7 ARID1A	1.31e-03	37	29	2	GO:0140658
GeneOntologyMolecularFunction	symporter activity	SLC6A7 SLC36A3 SLC12A5	1.32e-03	150	29	3	GO:0015293
GeneOntologyMolecularFunction	RNA polymerase II complex binding	ZNF326 BRD4	1.46e-03	39	29	2	GO:0000993
GeneOntologyMolecularFunction	neutral L-amino acid transmembrane transporter activity	SLC6A7 SLC36A3	1.61e-03	41	29	2	GO:0015175
GeneOntologyMolecularFunction	inorganic cation transmembrane transporter activity	CACNA1B SLC6A7 SLC36A3 TRPV3 SLC12A5	1.91e-03	627	29	5	GO:0022890
GeneOntologyMolecularFunction	RNA polymerase core enzyme binding	ZNF326 BRD4	1.94e-03	45	29	2	GO:0043175
GeneOntologyMolecularFunction	monoatomic cation transmembrane transporter activity	CACNA1B SLC6A7 SLC36A3 TRPV3 SLC12A5	2.45e-03	664	29	5	GO:0008324
GeneOntologyMolecularFunction	RNA polymerase binding	ZNF326 BRD4	4.00e-03	65	29	2	GO:0070063
GeneOntologyMolecularFunction	basal RNA polymerase II transcription machinery binding	ZNF326 BRD4	4.12e-03	66	29	2	GO:0001099
GeneOntologyMolecularFunction	basal transcription machinery binding	ZNF326 BRD4	4.12e-03	66	29	2	GO:0001098
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	CACNA1B SLC6A7 SLC36A3 TRPV3 SLC12A5	4.33e-03	758	29	5	GO:0015318
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	CACNA1B SLC6A7 TRPV3 SLC12A5	4.35e-03	465	29	4	GO:0046873
GeneOntologyMolecularFunction	L-amino acid transmembrane transporter activity	SLC6A7 SLC36A3	4.76e-03	71	29	2	GO:0015179
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	CACNA1B SLC6A7 SLC36A3 TRPV3 SLC12A5	5.24e-03	793	29	5	GO:0015075
GeneOntologyMolecularFunction	p53 binding	BRD4 TP73	5.57e-03	77	29	2	GO:0002039
GeneOntologyMolecularFunction	organic cation transmembrane transporter activity	SLC6A7 SLC36A3	6.44e-03	83	29	2	GO:0015101
GeneOntologyMolecularFunction	promoter-specific chromatin binding	CHD7 ISL1	6.44e-03	83	29	2	GO:1990841
GeneOntologyBiologicalProcess	regulation of calcium ion transport	CACNA1B TRPV3 CHD7 ISL1 AHNAK PRNP	4.94e-06	323	29	6	GO:0051924
GeneOntologyBiologicalProcess	calcium ion import	CACNA1B TRPV3 ISL1 PRNP	1.04e-05	98	29	4	GO:0070509
GeneOntologyBiologicalProcess	import across plasma membrane	CACNA1B SLC6A7 TRPV3 PRNP SLC12A5	1.58e-05	230	29	5	GO:0098739
GeneOntologyBiologicalProcess	monoatomic cation transport	CACNA1B SLC6A7 SLC36A3 TRPV3 CHD7 ISL1 AHNAK PRNP SLC12A5	1.92e-05	1157	29	9	GO:0006812
GeneOntologyBiologicalProcess	inorganic cation transmembrane transport	CACNA1B SLC6A7 SLC36A3 TRPV3 CHD7 AHNAK PRNP SLC12A5	2.87e-05	922	29	8	GO:0098662
GeneOntologyBiologicalProcess	monoatomic cation transmembrane transport	CACNA1B SLC6A7 SLC36A3 TRPV3 CHD7 AHNAK PRNP SLC12A5	3.35e-05	942	29	8	GO:0098655
GeneOntologyBiologicalProcess	calcium ion import across plasma membrane	CACNA1B TRPV3 PRNP	4.14e-05	48	29	3	GO:0098703
GeneOntologyBiologicalProcess	calcium ion import into cytosol	CACNA1B TRPV3 PRNP	4.14e-05	48	29	3	GO:1902656
GeneOntologyBiologicalProcess	inorganic ion import across plasma membrane	CACNA1B TRPV3 PRNP SLC12A5	4.47e-05	142	29	4	GO:0099587
GeneOntologyBiologicalProcess	inorganic cation import across plasma membrane	CACNA1B TRPV3 PRNP SLC12A5	4.47e-05	142	29	4	GO:0098659
GeneOntologyBiologicalProcess	metal ion transport	CACNA1B SLC6A7 TRPV3 CHD7 ISL1 AHNAK PRNP SLC12A5	5.12e-05	1000	29	8	GO:0030001
GeneOntologyBiologicalProcess	regulation of metal ion transport	CACNA1B TRPV3 CHD7 ISL1 AHNAK PRNP	5.38e-05	493	29	6	GO:0010959
GeneOntologyBiologicalProcess	inorganic ion transmembrane transport	CACNA1B SLC6A7 SLC36A3 TRPV3 CHD7 AHNAK PRNP SLC12A5	5.77e-05	1017	29	8	GO:0098660
GeneOntologyBiologicalProcess	calcium ion transport	CACNA1B TRPV3 CHD7 ISL1 AHNAK PRNP	6.43e-05	509	29	6	GO:0006816
GeneOntologyBiologicalProcess	monoatomic ion transport	CACNA1B SLC6A7 SLC36A3 TRPV3 CHD7 ISL1 AHNAK PRNP SLC12A5	7.44e-05	1374	29	9	GO:0006811
GeneOntologyBiologicalProcess	regulation of calcium ion import	TRPV3 ISL1 PRNP	8.51e-05	61	29	3	GO:0090279
GeneOntologyBiologicalProcess	proline transmembrane transport	SLC6A7 SLC36A3	1.04e-04	11	29	2	GO:0035524
GeneOntologyBiologicalProcess	monoatomic ion transmembrane transport	CACNA1B SLC6A7 SLC36A3 TRPV3 CHD7 AHNAK PRNP SLC12A5	1.10e-04	1115	29	8	GO:0034220
GeneOntologyBiologicalProcess	regulation of monoatomic ion transport	CACNA1B TRPV3 CHD7 ISL1 AHNAK PRNP	1.28e-04	577	29	6	GO:0043269
GeneOntologyBiologicalProcess	calcium ion transmembrane transport	CACNA1B TRPV3 CHD7 AHNAK PRNP	1.97e-04	392	29	5	GO:0070588
GeneOntologyBiologicalProcess	calcium ion transmembrane import into cytosol	CACNA1B TRPV3 CHD7 PRNP	2.30e-04	217	29	4	GO:0097553
GeneOntologyBiologicalProcess	cardiac right ventricle morphogenesis	CHD7 ISL1	3.94e-04	21	29	2	GO:0003215
GeneOntologyBiologicalProcess	positive regulation of cell differentiation	ISL1 MAP3K13 RREB1 ARID1A AP3B1 BRD4 TP73	8.29e-04	1141	29	7	GO:0045597
MousePheno	abnormal diencephalon morphology	CHD7 ISL1 AP3B1 PRNP TP73 SH2D3C	4.99e-06	298	22	6	MP:0000830
MousePheno	abnormal summary potential	CACNA1B SLC12A5	7.09e-06	3	22	2	MP:0003470
MousePheno	increased susceptibility to otitis media	CHD7 ISL1 TP73	1.48e-05	31	22	3	MP:0001850
MousePheno	increased thermal nociceptive threshold	CACNA1B TRPV3 CHD7 SLC12A5	2.21e-05	108	22	4	MP:0001973
MousePheno	ear inflammation	CHD7 ISL1 TP73	3.22e-05	40	22	3	MP:0001849
MousePheno	small Rathke's pouch	CHD7 ISL1	3.53e-05	6	22	2	MP:0013349
MousePheno	periorbital edema	CHD7 TP73	6.58e-05	8	22	2	MP:0001788
MousePheno	olfactory bulb hypoplasia	CHD7 SH2D3C	8.46e-05	9	22	2	MP:0010059
MousePheno	abnormal periorbital region morphology	CHD7 TP73	1.06e-04	10	22	2	MP:0030038
MousePheno	abnormal thermal nociception	CACNA1B TRPV3 CHD7 SLC12A5	1.24e-04	168	22	4	MP:0002733
MousePheno	hypoalgesia	CACNA1B TRPV3 CHD7 SLC12A5	1.30e-04	170	22	4	MP:0003043
MousePheno	abnormal cerebral cortex morphology	FILIP1 CHD7 AP3B1 PRNP TP73	1.31e-04	328	22	5	MP:0000788
MousePheno	abnormal forebrain morphology	FILIP1 CHD7 ISL1 ARID1A AP3B1 PRNP TP73 SH2D3C	1.41e-04	1072	22	8	MP:0000783
MousePheno	abnormal sleep duration	CACNA1B PRNP	1.82e-04	13	22	2	MP:0021198
MousePheno	abnormal brain white matter morphology	FILIP1 CHD7 AP3B1 PRNP	2.72e-04	206	22	4	MP:0008026
MousePheno	abnormal uterine horn morphology	CHD7 AP3B1	3.56e-04	18	22	2	MP:0009085
MousePheno	hemorrhage	CHD7 ARID1A AP3B1 F13A1 TP73 SLC12A5	4.36e-04	664	22	6	MP:0001914
MousePheno	decreased embryonic neuroepithelium thickness	CHD7 ISL1	4.42e-04	20	22	2	MP:0012703
MousePheno	pregnancy-related premature death	AP3B1 F13A1	5.86e-04	23	22	2	MP:0008028
MousePheno	abnormal pain threshold	CACNA1B TRPV3 CHD7 SLC12A5	7.26e-04	267	22	4	MP:0001970
MousePheno	conjunctivitis	CHD7 TP73	7.51e-04	26	22	2	MP:0001852
MousePheno	abnormal hypothalamus physiology	CACNA1B CHD7	7.51e-04	26	22	2	MP:0005645
MousePheno	abnormal neuron differentiation	CHD7 MAP3K13 PRNP SH2D3C	8.10e-04	275	22	4	MP:0009937
MousePheno	abnormal outer ear morphology	CHD7 ISL1 AP3B1	8.23e-04	119	22	3	MP:0002177
MousePheno	increased susceptibility to infection	TRPV3 AP3B1 AHNAK PRNP TP73	9.45e-04	504	22	5	MP:0002406
MousePheno	abnormal olfactory bulb morphology	CHD7 PRNP SH2D3C	1.14e-03	133	22	3	MP:0000819
MousePheno	lethality during fetal growth through weaning, incomplete penetrance	CACNA1B CHD7 AP3B1 GUCY1B1 BRD4 TP73 SH2D3C	1.24e-03	1124	22	7	MP:0011112
MousePheno	abnormal telencephalon morphology	FILIP1 CHD7 AP3B1 PRNP TP73 SH2D3C	1.26e-03	812	22	6	MP:0000787
MousePheno	abnormal malleus morphology	CHD7 ISL1	1.29e-03	34	22	2	MP:0000029
MousePheno	abnormal pituitary diverticulum morphology	CHD7 ISL1	1.44e-03	36	22	2	MP:0003817
MousePheno	abnormal blood circulation	CHD7 ARID1A AP3B1 F13A1 TP73 SLC12A5	1.55e-03	845	22	6	MP:0002128
MousePheno	abnormal olfactory lobe morphology	CHD7 PRNP SH2D3C	1.58e-03	149	22	3	MP:0009944
MousePheno	abnormal adenohypophysis development	CHD7 ISL1	1.61e-03	38	22	2	MP:0013337
Domain	p53-like_TF_DNA-bd	FUT5 TP73	3.27e-03	53	30	2	IPR008967
Pathway	KEGG_MEDICUS_VARIANT_SCRAPIE_CONFORMATION_PRPSC_TO_VGCC_CA2_APOPTOTIC_PATHWAY	CACNA1B PRNP	3.16e-05	6	21	2	M47762
Pubmed	ARID1A loss derepresses a group of human endogenous retrovirus-H loci to modulate BRD4-dependent transcription.	ARID1A BRD4	7.19e-07	2	30	2	35715442
Pubmed	BRD4 Regulates Metastatic Potential of Castration-Resistant Prostate Cancer through AHNAK.	AHNAK BRD4	7.19e-07	2	30	2	31110158
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	RPL21 MKI67 ZNF326 CHD7 RREB1 ARID1A RBM27 AHNAK BRD4	9.38e-07	1294	30	9	30804502
Pubmed	WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage.	CHD7 ARID1A AP3B1 RBM27 AHNAK BRD4	9.60e-07	394	30	6	27248496
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	MKI67 ZNF326 CHD7 RREB1 ARID1A RBM27 AHNAK BRD4	1.07e-06	954	30	8	36373674
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	RPL21 MKI67 ZNF326 CHD7 TOP1MT RREB1 AP3B1 RBM27 AHNAK	1.09e-06	1318	30	9	30463901
Pubmed	A new Prdm1-Cre line is suitable for studying the second heart field development.	MKI67 ISL1	2.16e-06	3	30	2	38880275
Pubmed	Activated Alk triggers prolonged neurogenesis and Ret upregulation providing a therapeutic target in ALK-mutated neuroblastoma.	MKI67 ISL1	2.16e-06	3	30	2	24811913
Pubmed	ARID1A influences HDAC1/BRD4 activity, intrinsic proliferative capacity and breast cancer treatment response.	ARID1A BRD4	2.16e-06	3	30	2	31913353
Pubmed	Emergence of sigh rhythmogenesis in the embryonic mouse.	ISL1 SLC12A5	2.16e-06	3	30	2	24591570
Pubmed	A genome-wide CRISPR screen identifies BRD4 as a regulator of cardiomyocyte differentiation.	ISL1 BRD4	2.16e-06	3	30	2	39196112
Pubmed	SWI/SNF protein component BAF250a regulates cardiac progenitor cell differentiation by modulating chromatin accessibility during second heart field development.	ISL1 ARID1A	4.31e-06	4	30	2	22621927
Pubmed	KSHV episome tethering sites on host chromosomes and regulation of latency-lytic switch by CHD4.	MKI67 RBM27 AHNAK BRD4	4.74e-06	130	30	4	35545047
Pubmed	The cellular prion protein identifies bipotential cardiomyogenic progenitors.	ISL1 PRNP	7.18e-06	5	30	2	19910576
Pubmed	The role of Zhx2 transcription factor in bipolar cell differentiation during mouse retinal development.	MKI67 ISL1	7.18e-06	5	30	2	30146259
Pubmed	Distinct timing of neurogenesis of ipsilateral and contralateral retinal ganglion cells.	MKI67 ISL1	7.18e-06	5	30	2	29761490
Pubmed	Congenital Diaphragmatic Hernia Overview	CHD7 ARID1A HCCS	8.57e-06	46	30	3	20301533
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	ZNF326 CHD7 ARID1A AP3B1 AHNAK BRD4	9.03e-06	582	30	6	20467437
Pubmed	The C terminus of p73 is essential for hippocampal development.	MKI67 TP73	1.08e-05	6	30	2	32571922
Pubmed	Aquaporin-9 is expressed in a mucus-secreting goblet cell subset in the small intestine.	MKI67 ISL1	1.08e-05	6	30	2	12681500
Pubmed	Gonadotropin-releasing hormone-1 (GnRH-1) is involved in tooth maturation and biomineralization.	MKI67 ISL1	1.51e-05	7	30	2	17948256
Pubmed	Programmed Cell Senescence in the Mouse Developing Spinal Cord and Notochord.	MKI67 ISL1	1.51e-05	7	30	2	33575260
Pubmed	The SH2 domain protein Shep1 regulates the in vivo signaling function of the scaffolding protein Cas.	MKI67 SH2D3C	1.51e-05	7	30	2	20603213
Pubmed	CHD7 promotes proliferation of neural stem cells mediated by MIF.	MKI67 CHD7	1.51e-05	7	30	2	27955690
Pubmed	Comparative expression analysis of POU4F1, POU4F2 and ISL1 in developing mouse cochleovestibular ganglion neurons.	MKI67 ISL1	1.51e-05	7	30	2	24709358
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	RPL21 MKI67 ZNF326 CHD7 GNL3L AP3B1 RBM27 AHNAK	1.54e-05	1371	30	8	36244648
Pubmed	Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells.	ZNF326 GNL3L RREB1 AHNAK	1.60e-05	177	30	4	26206133
Pubmed	MicroRNA-9 regulates neurogenesis in mouse telencephalon by targeting multiple transcription factors.	MKI67 ISL1 TP73	1.64e-05	57	30	3	21368052
Pubmed	A common Shox2-Nkx2-5 antagonistic mechanism primes the pacemaker cell fate in the pulmonary vein myocardium and sinoatrial node.	MKI67 ISL1	2.01e-05	8	30	2	26138475
Pubmed	Wnt/β-catenin and sonic hedgehog pathways interact in the regulation of the development of the dorsal mesenchymal protrusion.	MKI67 ISL1	2.01e-05	8	30	2	26297872
Pubmed	Cooperative interaction of Nkx2.5 and Mef2c transcription factors during heart development.	MKI67 ISL1	2.01e-05	8	30	2	19035347
Pubmed	p73 regulates epidermal wound healing and induced keratinocyte programming.	MKI67 TP73	2.01e-05	8	30	2	31216312
Pubmed	Dysregulation of cotranscriptional alternative splicing underlies CHARGE syndrome.	MKI67 CHD7	2.01e-05	8	30	2	29311329
Pubmed	Cholinergic input is required during embryonic development to mediate proper assembly of spinal locomotor circuits.	ISL1 SLC12A5	2.01e-05	8	30	2	15820692
Pubmed	H3K27me3 demethylase UTX regulates the differentiation of a subset of bipolar cells in the mouse retina.	MKI67 ISL1	2.01e-05	8	30	2	32215989
Pubmed	Influence of mesodermal Fgf8 on the differentiation of neural crest-derived postganglionic neurons.	MKI67 ISL1	2.01e-05	8	30	2	22040872
Pubmed	Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study.	MKI67 AP3B1 F13A1	2.12e-05	62	30	3	17975119
Pubmed	Gene variants associated with ischemic stroke: the cardiovascular health study.	MKI67 AP3B1 F13A1	2.22e-05	63	30	3	19023099
Pubmed	TRPV2 enhances axon outgrowth through its activation by membrane stretch in developing sensory and motor neurons.	MKI67 ISL1	2.58e-05	9	30	2	20357111
Pubmed	Blastocyst implantation failure relates to impaired translational machinery gene expression.	RPL21 MKI67	2.58e-05	9	30	2	24700326
Pubmed	Expression analysis of the Islet-1 gene in the developing and adult gastrointestinal tract.	MKI67 ISL1	2.58e-05	9	30	2	21220053
Pubmed	Expression of the basic helix-loop-factor Olig2 in the developing retina: Olig2 as a new marker for retinal progenitors and late-born cells.	MKI67 ISL1	3.22e-05	10	30	2	16815098
Pubmed	OLIG2 is an in vivo bookmarking transcription factor in the developing neural tube in mouse.	MKI67 ISL1	3.22e-05	10	30	2	36547371
Pubmed	SoxC Transcription Factors Promote Contralateral Retinal Ganglion Cell Differentiation and Axon Guidance in the Mouse Visual System.	MKI67 ISL1	3.22e-05	10	30	2	28215559
Pubmed	LIM homeodomain transcription factor-dependent specification of bipotential MGE progenitors into cholinergic and GABAergic striatal interneurons.	MKI67 ISL1	3.22e-05	10	30	2	19855026
Pubmed	SoxC transcription factors shape the epigenetic landscape to establish competence for sensory differentiation in the mammalian organ of Corti.	MKI67 ISL1	3.94e-05	11	30	2	37585469
Pubmed	Transcription factor LIM homeobox 7 (Lhx7) maintains subtype identity of cholinergic interneurons in the mammalian striatum.	MKI67 ISL1	3.94e-05	11	30	2	22315402
Pubmed	Lhx4 deficiency: increased cyclin-dependent kinase inhibitor expression and pituitary hypoplasia.	MKI67 ISL1	3.94e-05	11	30	2	25668206
Pubmed	Dkk1 regulates ventral midbrain dopaminergic differentiation and morphogenesis.	MKI67 ISL1	3.94e-05	11	30	2	21347250
Pubmed	Estrogen Receptor α Regulates β-Cell Formation During Pancreas Development and Following Injury.	MKI67 ISL1	3.94e-05	11	30	2	26015547
Pubmed	SOX21 modulates SOX2-initiated differentiation of epithelial cells in the extrapulmonary airways.	MKI67 TP73	3.94e-05	11	30	2	34286693
Pubmed	Temporally restricted death and the role of p75NTR as a survival receptor in the developing sensory nervous system.	MKI67 ISL1	3.94e-05	11	30	2	29569362
Pubmed	Epigenetic Regulation by Suv4-20h1 in Cardiopulmonary Progenitor Cells Is Required to Prevent Pulmonary Hypertension and Chronic Obstructive Pulmonary Disease.	MKI67 ISL1	3.94e-05	11	30	2	34247492
Pubmed	Arid1a regulates bladder urothelium formation and maintenance.	MKI67 ARID1A	4.72e-05	12	30	2	35283102
Pubmed	The ATP-dependent chromatin remodeling enzyme CHD7 regulates pro-neural gene expression and neurogenesis in the inner ear.	CHD7 ISL1	4.72e-05	12	30	2	20736290
Pubmed	Generation of Cajal-Retzius neurons in mouse forebrain is regulated by transforming growth factor beta-Fox signaling pathways.	MKI67 TP73	4.72e-05	12	30	2	18005957
Pubmed	Insm1 promotes neurogenic proliferation in delaminated otic progenitors.	MKI67 ISL1	4.72e-05	12	30	2	26545349
Pubmed	p53 Activity Dominates That of p73 upon Mdm4 Loss in Development and Tumorigenesis.	MKI67 TP73	4.72e-05	12	30	2	26527653
Pubmed	HIF-1α is required for development of the sympathetic nervous system.	MKI67 ISL1	4.72e-05	12	30	2	31196952
Pubmed	ISL1 regulates lung branching morphogenesis via Shh signaling pathway.	MKI67 ISL1	4.72e-05	12	30	2	37442233
Pubmed	Netrin1/DCC signaling promotes neuronal migration in the dorsal spinal cord.	MKI67 ISL1	4.72e-05	12	30	2	27784329
Pubmed	Critical roles of ARHGAP36 as a signal transduction mediator of Shh pathway in lateral motor columnar specification.	MKI67 ISL1	4.72e-05	12	30	2	31305241
Pubmed	Airway basal cells show regionally distinct potential to undergo metaplastic differentiation.	MKI67 ISL1	4.72e-05	12	30	2	36178196
Pubmed	Cell type-selective expression of the zinc finger-containing gene Nolz-1/Zfp503 in the developing mouse striatum.	MKI67 ISL1	4.72e-05	12	30	2	23684982
Pubmed	A cochlear progenitor pool influences patterning of the mammalian sensory epithelium via MYBL2.	MKI67 ISL1	4.72e-05	12	30	2	39254648
Pubmed	Defective postnatal neurogenesis and disorganization of the rostral migratory stream in absence of the Vax1 homeobox gene.	MKI67 ISL1	5.58e-05	13	30	2	15590934
Pubmed	Prdx4 is a compartment-specific H2O2 sensor that regulates neurogenesis by controlling surface expression of GDE2.	MKI67 ISL1	5.58e-05	13	30	2	25943695
Pubmed	The antioxidant enzyme Prdx1 controls neuronal differentiation by thiol-redox-dependent activation of GDE2.	MKI67 ISL1	5.58e-05	13	30	2	19766572
Pubmed	Reticulons 1 and 3 are essential for axonal growth and synaptic maintenance associated with intellectual development.	MKI67 TP73	5.58e-05	13	30	2	37228035
Pubmed	UTX, a histone H3-lysine 27 demethylase, acts as a critical switch to activate the cardiac developmental program.	MKI67 ISL1	5.58e-05	13	30	2	22192413
Pubmed	Generation of cerebellar neuron precursors from embryonic stem cells.	MKI67 ISL1	5.58e-05	13	30	2	16406324
Pubmed	Early ear neuronal development, but not olfactory or lens development, can proceed without SOX2.	MKI67 ISL1	5.58e-05	13	30	2	31526806
Pubmed	Neurogenin2 identifies a transplantable dopamine neuron precursor in the developing ventral mesencephalon.	MKI67 ISL1	5.58e-05	13	30	2	16438966
Pubmed	Conditional deletion of activating protein 2alpha (AP-2alpha) in the developing retina demonstrates non-cell-autonomous roles for AP-2alpha in optic cup development.	MKI67 ISL1	5.58e-05	13	30	2	17724084
Pubmed	WDR1-regulated actin dynamics is required for outflow tract and right ventricle development.	MKI67 ISL1	5.58e-05	13	30	2	29654745
Pubmed	Homozygous mutation of VPS16 gene is responsible for an autosomal recessive adolescent-onset primary dystonia.	MKI67 CHD7	5.58e-05	13	30	2	27174565
Pubmed	Homeobox Gene Six3 is Required for the Differentiation of D2-Type Medium Spiny Neurons.	MKI67 ISL1	5.58e-05	13	30	2	34014554
Pubmed	Tlx controls proliferation and patterning of lateral telencephalic progenitor domains.	MKI67 ISL1	5.58e-05	13	30	2	14627641
Pubmed	Compromised cell competition exhausts neural stem cells pool.	MKI67 BRD4	5.58e-05	13	30	2	39010274
Pubmed	SARS-CoV-2 N Protein Antagonizes Stress Granule Assembly and IFN Production by Interacting with G3BPs to Facilitate Viral Replication.	ZNF326 GNL3L RBM27 AHNAK	5.70e-05	245	30	4	35652658
Pubmed	Cux2 (Cutl2) integrates neural progenitor development with cell-cycle progression during spinal cord neurogenesis.	MKI67 ISL1	6.50e-05	14	30	2	18223201
Pubmed	Evaluating Effects of Hypomorphic Thoc1 Alleles on Embryonic Development in Rb1 Null Mice.	MKI67 TP73	6.50e-05	14	30	2	27001308
Pubmed	Genetic control of dorsal-ventral identity in the telencephalon: opposing roles for Pax6 and Gsh2.	MKI67 ISL1	6.50e-05	14	30	2	11003836
Pubmed	Shh and Gli3 activities are required for timely generation of motor neuron progenitors.	MKI67 ISL1	6.50e-05	14	30	2	19433083
Pubmed	The mouse homeobox gene Gbx2 is required for the development of cholinergic interneurons in the striatum.	MKI67 ISL1	6.50e-05	14	30	2	21048141
Pubmed	Chd7 is indispensable for mammalian brain development through activation of a neuronal differentiation programme.	MKI67 CHD7	6.50e-05	14	30	2	28317875
Pubmed	Expression of the BMP receptor Alk3 in the second heart field is essential for development of the dorsal mesenchymal protrusion and atrioventricular septation.	MKI67 ISL1	6.50e-05	14	30	2	23584254
Pubmed	Pituitary adenylyl cyclase-activating peptide counteracts hedgehog-dependent motor neuron production in mouse embryonic stem cell cultures.	MKI67 ISL1	6.50e-05	14	30	2	21674568
Pubmed	Emx2 in the developing hippocampal fissure region.	MKI67 TP73	6.50e-05	14	30	2	16819978
Pubmed	A conserved regulatory logic controls temporal identity in mouse neural progenitors.	MKI67 ISL1	7.50e-05	15	30	2	25654255
Pubmed	Combined activities of hedgehog signaling inhibitors regulate pancreas development.	MKI67 ISL1	7.50e-05	15	30	2	12917290
Pubmed	The Wnt receptor Ryk controls specification of GABAergic neurons versus oligodendrocytes during telencephalon development.	MKI67 ISL1	7.50e-05	15	30	2	21205786
Pubmed	AML1/Runx1 is important for the development of hindbrain cholinergic branchiovisceral motor neurons and selected cranial sensory neurons.	MKI67 ISL1	7.50e-05	15	30	2	15240886
Pubmed	CHARGE syndrome-associated CHD7 acts at ISL1-regulated enhancers to modulate second heart field gene expression.	CHD7 ISL1	7.50e-05	15	30	2	37052590
Pubmed	Binary Fate Choice between Closely Related Interneuronal Types Is Determined by a Fezf1-Dependent Postmitotic Transcriptional Switch.	MKI67 ISL1	7.50e-05	15	30	2	31812516
Pubmed	Ebf2 is required for development of dopamine neurons in the midbrain periaqueductal gray matter of mouse.	MKI67 ISL1	7.50e-05	15	30	2	25762221
Pubmed	Integral bHLH factor regulation of cell cycle exit and RGC differentiation.	MKI67 ISL1	7.50e-05	15	30	2	29770538
Pubmed	A role for Gsh1 in the developing striatum and olfactory bulb of Gsh2 mutant mice.	MKI67 ISL1	7.50e-05	15	30	2	11731457
Pubmed	Mash1 and Math3 are required for development of branchiomotor neurons and maintenance of neural progenitors.	MKI67 ISL1	7.50e-05	15	30	2	15976074
Pubmed	Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.	CHD7 ARID1A RBM27 BRD4	8.07e-05	268	30	4	33640491
Interaction	HASPIN interactions	MKI67 AHNAK BRD4 PRNP TP73	6.85e-07	123	28	5	int:HASPIN
Interaction	HDLBP interactions	RPL21 MKI67 ZNF326 CHD7 GNL3L AP3B1 RBM27 AHNAK	1.48e-05	855	28	8	int:HDLBP
Interaction	TBR1 interactions	CHD7 ARID1A BRD4 PRNP	1.73e-05	113	28	4	int:TBR1
Interaction	BRD9 interactions	ARID1A AP3B1 BRD4 PRNP	1.98e-05	117	28	4	int:BRD9
Interaction	ESRRB interactions	ZNF326 GNL3L RREB1 ARID1A AHNAK	2.75e-05	262	28	5	int:ESRRB
Interaction	CHD4 interactions	RPL21 MKI67 ZNF326 GNL3L TOP1MT ARID1A AHNAK BRD4	2.89e-05	938	28	8	int:CHD4
Interaction	BRCA1 interactions	RPL21 MKI67 ZNF326 GNL3L ARID1A EXD2 AHNAK BRD4 TP73	3.09e-05	1249	28	9	int:BRCA1
Interaction	CTCF interactions	RPL21 MKI67 ZNF326 CHD7 ARID1A BRD4	3.41e-05	461	28	6	int:CTCF
Interaction	H2BC21 interactions	MKI67 CHD7 TOP1MT RREB1 ARID1A AHNAK BRD4	3.57e-05	696	28	7	int:H2BC21
Interaction	SMC5 interactions	MKI67 ZNF326 CHD7 RREB1 ARID1A RBM27 AHNAK BRD4	4.57e-05	1000	28	8	int:SMC5
Interaction	HMGB1 interactions	RPL21 ZNF326 AHNAK BRD4 PRNP TP73	4.58e-05	486	28	6	int:HMGB1
Interaction	RCOR1 interactions	MKI67 CHD7 RREB1 AHNAK BRD4 PRNP	5.01e-05	494	28	6	int:RCOR1
Interaction	CHD7 interactions	RPL21 MKI67 CHD7 ARID1A	5.25e-05	150	28	4	int:CHD7
Interaction	IRF2BPL interactions	MKI67 BRD4 PRNP	5.37e-05	53	28	3	int:IRF2BPL
Interaction	SNW1 interactions	MKI67 ZNF326 CHD7 ARID1A AP3B1 AHNAK BRD4	5.60e-05	747	28	7	int:SNW1
Interaction	FUBP1 interactions	MKI67 ZNF326 RBM27 BRD4 PRNP	6.04e-05	309	28	5	int:FUBP1
Interaction	MYCN interactions	RPL21 MKI67 ZNF326 CHD7 ISL1 GNL3L ARID1A PRNP TP73	6.50e-05	1373	28	9	int:MYCN
Interaction	NR2C2 interactions	RPL21 MKI67 ZNF326 CHD7 TOP1MT RREB1 AP3B1 RBM27 AHNAK	7.69e-05	1403	28	9	int:NR2C2
Interaction	COMT interactions	HCCS BRD4 PRNP SH2D3C	8.74e-05	171	28	4	int:COMT
Interaction	POLD1 interactions	MKI67 ZNF326 AP3B1 AHNAK BRD4	9.09e-05	337	28	5	int:POLD1
Interaction	TERF2IP interactions	MKI67 CHD7 RREB1 ARID1A RBM27 BRD4	9.26e-05	552	28	6	int:TERF2IP
Interaction	NUP50 interactions	CHD7 ARID1A RBM27 BRD4 PRNP	9.61e-05	341	28	5	int:NUP50
Interaction	WDR48 interactions	MKI67 ARID1A BRD4 PRNP	9.99e-05	177	28	4	int:WDR48
Interaction	PAFAH1B3 interactions	BRD4 PRNP SH2D3C	1.04e-04	66	28	3	int:PAFAH1B3
Interaction	SMARCD2 interactions	MKI67 ARID1A BRD4 TP73	1.14e-04	183	28	4	int:SMARCD2
Interaction	NAT8L interactions	TRPV3 PRNP	1.22e-04	12	28	2	int:NAT8L
Interaction	DUXA interactions	MKI67 CHD7	1.22e-04	12	28	2	int:DUXA
Interaction	CHD8 interactions	MKI67 CHD7 AP3B1 BRD4	1.39e-04	193	28	4	int:CHD8
Interaction	DIS3 interactions	AHNAK BRD4 PRNP SH2D3C	1.42e-04	194	28	4	int:DIS3
Interaction	NFIC interactions	MKI67 RREB1 ARID1A BRD4	1.93e-04	210	28	4	int:NFIC
Interaction	SOX7 interactions	CHD7 RREB1 ARID1A	1.98e-04	82	28	3	int:SOX7
Interaction	ACTN4 interactions	MKI67 ARID1A AHNAK PRNP SH2D3C	2.03e-04	400	28	5	int:ACTN4
Interaction	PGM3 interactions	BRD4 PRNP SH2D3C	2.05e-04	83	28	3	int:PGM3
Interaction	IK interactions	MKI67 ZNF326 ARID1A BRD4	2.11e-04	215	28	4	int:IK
Interaction	NQO1 interactions	BRD4 TP73 SH2D3C	2.12e-04	84	28	3	int:NQO1
Interaction	PRC1 interactions	RPL21 MKI67 ZNF326 TOP1MT ARID1A AHNAK BRD4	2.90e-04	973	28	7	int:PRC1
Interaction	SOX9 interactions	CHD7 ARID1A BRD4	3.24e-04	97	28	3	int:SOX9
Interaction	AR interactions	ZNF326 CHD7 RREB1 ARID1A RBM27 BRD4 SH2D3C	3.27e-04	992	28	7	int:AR
Interaction	FKBP15 interactions	ZNF326 AP3B1 BRD4	3.45e-04	99	28	3	int:FKBP15
Interaction	ASF1A interactions	CHD7 RREB1 ARID1A TP73	3.69e-04	249	28	4	int:ASF1A
Interaction	LHX1 interactions	CHD7 ISL1 ARID1A	3.87e-04	103	28	3	int:LHX1
Interaction	PES1 interactions	MKI67 GNL3L AP3B1 BRD4	4.22e-04	258	28	4	int:PES1
Interaction	TAF10 interactions	MKI67 BRD4 PRNP	4.33e-04	107	28	3	int:TAF10
Interaction	AFAP1L2 interactions	RPL21 PRNP	4.63e-04	23	28	2	int:AFAP1L2
Interaction	NUDT14 interactions	GNL3L PRNP	4.63e-04	23	28	2	int:NUDT14
Interaction	SIRT7 interactions	RPL21 MKI67 CHD7 ARID1A AHNAK BRD4	4.66e-04	744	28	6	int:SIRT7
Interaction	POLR1G interactions	CHD7 GNL3L RREB1 BRD4 PRNP	5.10e-04	489	28	5	int:POLR1G
Interaction	CHD3 interactions	RPL21 MKI67 ZNF326 ARID1A BRD4 TP73	5.11e-04	757	28	6	int:CHD3
Interaction	HNF4A interactions	CHD7 ISL1 RREB1 ARID1A	5.37e-04	275	28	4	int:HNF4A
Interaction	H3C3 interactions	MKI67 CHD7 GNL3L RREB1 BRD4	5.39e-04	495	28	5	int:H3C3
Interaction	ZNF740 interactions	BRD4 PRNP	5.48e-04	25	28	2	int:ZNF740
Interaction	GRK7 interactions	MKI67 AHNAK	5.48e-04	25	28	2	int:GRK7
Interaction	FAM50A interactions	RPL21 GNL3L BRD4	5.48e-04	116	28	3	int:FAM50A
Interaction	CIT interactions	RPL21 MKI67 ZNF326 TOP1MT RREB1 RBM27 AHNAK PRNP	5.95e-04	1450	28	8	int:CIT
Interaction	MRE11 interactions	MKI67 EXD2 BRD4 PRNP	6.30e-04	287	28	4	int:MRE11
Interaction	RBBP5 interactions	MKI67 CHD7 ARID1A BRD4	6.30e-04	287	28	4	int:RBBP5
Interaction	SUMO1 interactions	MKI67 RBM27 BRD4 TP73	6.30e-04	287	28	4	int:SUMO1
Interaction	PAX7 interactions	CHD7 RREB1 ARID1A	6.66e-04	124	28	3	int:PAX7
Interaction	BTF3 interactions	RPL21 MKI67 CHD7 AHNAK BRD4 PRNP	6.79e-04	799	28	6	int:BTF3
Interaction	CHRNA7 interactions	GUCY1B1 PRNP	6.88e-04	28	28	2	int:CHRNA7
Cytoband	5q32	SLC6A7 RBM27	5.78e-04	54	30	2	5q32
Cytoband	Ensembl 112 genes in cytogenetic band chr5q32	SLC6A7 RBM27	1.26e-03	80	30	2	chr5q32
Disease	peptide measurement	CACNA1B RBM27 SH2D3C	1.85e-04	109	30	3	EFO_0010520
Disease	colorectal cancer (is_implicated_in)	MKI67 TRPV3 TP73	2.52e-04	121	30	3	DOID:9256 (is_implicated_in)
Disease	stomach cancer (is_marker_for)	MKI67 ARID1A TP73	4.03e-04	142	30	3	DOID:10534 (is_marker_for)
Disease	breast cancer (is_implicated_in)	MKI67 ARID1A TP73	4.73e-04	150	30	3	DOID:1612 (is_implicated_in)
Disease	colon cancer (is_implicated_in)	ARID1A BRD4	6.16e-04	36	30	2	DOID:219 (is_implicated_in)
Disease	monocyte percentage of leukocytes	CHD7 ARID1A RBM27 AHNAK SH2D3C	7.85e-04	731	30	5	EFO_0007989
Disease	Neoplasm of uncertain or unknown behavior of breast	MAP3K13 ARID1A	7.99e-04	41	30	2	C0496956
Disease	Breast adenocarcinoma	MAP3K13 ARID1A	7.99e-04	41	30	2	C0858252
Disease	Neuroblastoma	ISL1 ARID1A	1.05e-03	47	30	2	C0027819
Disease	Peripheral Nervous System Diseases	MKI67 CACNA1B	1.38e-03	54	30	2	C4721453
Disease	cutaneous melanoma, hair color	RREB1 AHNAK	1.82e-03	62	30	2	EFO_0000389, EFO_0003924
Disease	transitional cell carcinoma (is_marker_for)	BRD4 TP73	1.88e-03	63	30	2	DOID:2671 (is_marker_for)

Protein segments in the cluster

Peptide	Gene	Start	Entry
MAPKSKKKGHPGREQ	BRD4	721	O60885
LKGPKLKMPDMHVNM	AHNAK	3276	Q09666
SKFKMPKIHMSGPKI	AHNAK	5021	Q09666
PMHEGKMKGCPVNTE	HCCS	26	P53701
EMLKHMSPPLGLGKK	CACNA1B	1751	Q00975
NKRNGKKMGGAMAPP	CHD7	2651	Q9P2D1
EKKLPIGMKMHVFNP	AP3B1	921	O00203
PSTVHGGIQKMMSKP	RBM27	721	Q9P2N5
FLHSGMKMQKAGPPV	ARID1A	1606	O14497
RNKKSKMDGMVPGNH	EXD2	316	Q9NVH0
VHLDGPGVTRPMKKM	F13A1	666	P00488
HRGPVSMKGKKEPMQ	GUCY1B1	586	Q02153
RNLMPSAGKAMHTPK	MKI67	1286	P46013
PNAMEKLMKRKGVPH	MAP3K13	526	O43283
KLMKRKGVPHKSGMQ	MAP3K13	531	O43283
LSPMNKVHGGMNKLP	TP73	411	O15350
NPKGGISSKMLPMKH	KIAA1210	1246	Q9ULL0
MPKVMKDVVHPLGGE	DCST2	1	Q5T1A1
KKKPVQAPRMGTFMG	SLC12A5	111	Q9H2X9
GRSHKPLPKGTMMET	FUT5	236	Q11128
TPTRIPMSKGMKAGK	FILIP1	1156	Q7Z7B0
MMKLRHKNKKPGEGS	GNL3L	1	Q9NVN8
MGDMGDPPKKKRLIS	ISL1	1	P61371
AGSQSPKPLMVHMRK	SLC6A7	596	Q99884
GVGMVLPLKNQMKHP	SLC36A3	266	Q495N2
FMTAPGGKKTPAMRK	RREB1	626	Q92766
GDHPKMGMLKRRITP	TOP1MT	201	Q969P6
KPSKPKTNMKHMAGA	PRNP	101	P04156
DIKGMGTVQKGMPHK	RPL21	41	P46778
MKAHPKEMVPLMGKR	TRPV3	1	Q8NET8
HMGTMPRPSIKKAQN	SH2D3C	76	Q8N5H7
GIKRKMMQPFNKPSG	ZNF326	236	Q5BKZ1