Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
Pubmed

Binding of liganded vitamin D receptor to the vitamin D receptor interacting protein coactivator complex induces interaction with RNA polymerase II holoenzyme.

MED14 POLR2A

5.80e-06527210753860
Pubmed

GPR15-mediated homing controls immune homeostasis in the large intestine mucosa.

ITGA4 IL21R

1.22e-05727223661644
Pubmed

A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation.

MED14 POLR2A

5.25e-051427210024883
Pubmed

The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription.

MED14 POLR2A

7.84e-051727216109376
Pubmed

The Wilms tumor gene, Wt1, maintains testicular cord integrity by regulating the expression of Col4a1 and Col4a2.

ITGA4 DHH

1.21e-042127223325811
Pubmed

Genome-scale RNAi screen for host factors required for HIV replication.

PKLR MED14 TMEM131L HMCN2

1.66e-0436127418976975
Pubmed

MED1/TRAP220 exists predominantly in a TRAP/ Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription.

MED14 POLR2A

3.21e-043427215989967
Pubmed

MEGF10 and MEGF11 mediate homotypic interactions required for mosaic spacing of retinal neurons.

ITGA4 ABCC8

3.40e-043527222407321
Pubmed

A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology.

MED14 POLR2A

6.14e-044727215175163
Pubmed

Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program.

PKLR ABCC8

7.23e-045127220682687
ToppCellfacs-Lung-EPCAM-24m-Myeloid-Ccr7+_Dendritic|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZMYND15 TMEM131L ITGA4 IL21R

3.96e-061792741b979e0203a2ddfe98bf6c2c80c4af1ba437a80f
ToppCellfacs-Lung-EPCAM-24m-Myeloid-dendritic_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZMYND15 TMEM131L ITGA4 IL21R

3.96e-0617927451872338e54c5f3e42ca9f1c4cf1e8b0cb84afcc
ToppCellfacs-Lung-24m-Hematologic-myeloid-myeloid_dendritic_cell-Ccr7+_dendritic|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ZMYND15 TMEM131L ITGA4 IL21R

4.51e-0618527419fa853f6f746ccf232a343b3c9c7a5e55800409
ToppCellParenchymal-10x5prime-Immune_Lymphocytic-NK-ILC-T_NK-NK_CD11d|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

BTBD17 ITGA4 APMAP IL21R

6.14e-06200274eda7a1d822e8663510662bc0ca34eaccc88d71ca
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell_prolif|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ACP7 HMCN2 DHH

7.99e-05139273b07929348ec9ad95d7bce33a7deac0938227b19f
ToppCellLPS-IL1RA+antiTNF-Myeloid-Dendritic_cells-Monocytes-Macrophages|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ITGA4 HMCN2 IL21R

9.25e-05146273b76110b159acd27a2c8d6a9f98336608ace1ec12
ToppCellChildren_(3_yrs)-Mesenchymal-airway_smooth_muscle_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

LDB3 HMCN2 ABCC8

1.10e-04155273cd7d95cbcad248670e531d80bb83c55e36ebc573
ToppCellfacs-Aorta-Heart-3m-Mesenchymal-fibrocyte|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZMYND15 ITGA4 IL21R

1.33e-041652738a52f2dbcbd2bc1662b5e3fac381463fdcc3bf14
ToppCellsystemic_lupus_erythematosus-flare-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-male|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

BTBD17 ITGA4 APMAP

1.40e-04168273b94b1f37c92e019d01ecfa3b7cc6797b6e4a56ff
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Monocytic-Non-classical_Monocyte|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TMEM131L ITGA4 ABCC8

1.43e-04169273c3d410a5e98000ba872141b62e17ef4ed3d1a8eb
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal--glomerular_mesenchymal_cell-Renin-positive_Juxtaglomerular_Granular_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TMEM131L LDB3 ABCC8

1.45e-0417027399dd734c0972a40d5381e8e2d96bdaa31f6d06e6
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal--glomerular_mesenchymal_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TMEM131L LDB3 ABCC8

1.45e-041702733a14eeae221b8bb0bd0dadcb8e7a603431240a1e
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TMEM131L LDB3 ABCC8

1.45e-04170273cdb6fad277f284c3fd5a6f45672a8edc24715882
ToppCellprimary_auditory_cortex_(A1C)|World / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TSNAXIP1 ACP7 HMCN2

1.50e-0417227320ea9db009370aa6235365ce93e153eb5b28db94
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TMEM131L LDB3 ESPNL

1.58e-04175273d52794426f2703a80e91ae0a8ff2d8e0ce4aa4a8
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TMEM131L LDB3 ESPNL

1.58e-04175273454f03e6109d65f5db08dbb41ecc19ffb6bbc4e0
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Lymphocytic_B-B_Cell-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TMEM131L ITGA4 IL21R

1.61e-04176273d0a3e176df1270968efa79c00dc941c5e1c4f7aa
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Lymphocytic_B-B_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TMEM131L ITGA4 IL21R

1.61e-04176273274458d80f9f3f080248cbf64e4784ef351e7254
ToppCell5'-GW_trimst-1.5-SmallIntestine-Epithelial-neuro-epithelial-I_cells_(INS+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

BTBD17 ADAM29 ABCC8

1.72e-041802730c5d9245b8a7cc34ad52522d31559906cda55bdf
ToppCelldroplet-Tongue-nan-24m-Myeloid-Langerhans_cell|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZMYND15 ITGA4 IL21R

1.77e-041822730f06309318c064f0ebdb12a46226b90032290137
ToppCell356C-Lymphocytic-CD8+_Cytotoxic_T-cell|356C / Donor, Lineage, Cell class and subclass (all cells)

BTBD17 ITGA4 APMAP

1.83e-041842735b4f18b26d03e8e5798cac70d124534749fc4cc0
ToppCell3'-GW_trimst-1-SmallIntestine-Neuronal-Glial_immature-Glia_1_(DHH+)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ITGA4 DHH LRRC52

1.86e-04185273dd17025d8c423aa0a451ac7f1f301c93528e0229
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TMEM131L LDB3 ITGA4

1.92e-04187273530e4e6d91b5c0d9aa4543caa2b734a1674c5788
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TMEM131L LDB3 ITGA4

1.92e-04187273ec4b694487cc446999c7b27b119950a4f252c4b3
ToppCellFetal_29-31_weeks-Immune-natural_killer_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ITGA4 APMAP IL21R

1.95e-041882736686dbba990066568aa7573e70a7db8b4758f457
ToppCelldroplet-Kidney-nan-3m-Epithelial-Pecam____Kidney_cortex_artery_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LDB3 DHH ABCC8

1.95e-04188273ec0e241de2c8310b4417b9d4e2420d7a1662f1c0
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TMEM131L LDB3 ABCC8

1.98e-041892737fbe855bfdb47d35e040b04a80fe4b729a3764e8
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Immune-Lymphocytic_T/NK-T_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TMEM131L ITGA4 IL21R

1.98e-04189273b87d586a9570fa54f3e0c6bd4731c5badcaedae6
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Immune-Lymphocytic_T/NK|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TMEM131L ITGA4 IL21R

1.98e-04189273823d6debd09e440ddf36c54af24a5f20e222a21e
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Immune-Lymphocytic_T/NK-T_Cell-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TMEM131L ITGA4 IL21R

1.98e-0418927347c2b419b081d5bf75da5e3d9a0e05a70362dfe7
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TMEM131L LDB3 ABCC8

1.98e-0418927306b35abecd29f902cf251fcc1f6ad33db7ab08a2
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LDB3 HMCN2 ABCC8

2.01e-041902732e88e366d377d74deb53a4ea870973ce5c6532e8
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LDB3 HMCN2 ABCC8

2.01e-041902730028f886c789ba238c031eae5d96acaed4af8c25
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TMEM131L LDB3 ABCC8

2.08e-04192273b54b0d5b88139905521c8d5d58332e89c08d589c
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TMEM131L LDB3 ITGA4

2.08e-0419227324e2f15f5767a97eb3b389922bcfd7b13805e1ce
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TMEM131L LDB3 ABCC8

2.08e-04192273bfab13793e54de2550ee171397f7ece0625cdb4a
ToppCell10x5'-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8|lymph-node_spleen / Manually curated celltypes from each tissue

TMEM131L POLR2A MAP3K2

2.08e-0419227347646d7e4990be85072987f92bf18d52f8da752e
ToppCellnucseq-Immune-Lymphocytic_T/NK-Lymphocytic_T/NK-NK|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ITGA4 APMAP IL21R

2.08e-04192273a06d5d3c2537f8d2b1dc6b6f3e88a80b5c2a1850
ToppCellSmart-seq2-blood_(Smart-seq2)-lymphocytic-T_lymphocytic-CD8-positive,_alpha-beta_T_cell|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

ITGA4 UBE2V1 APMAP

2.11e-04193273a77a6018a88291fb466cb9cd13eff4164b0cc8f1
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_myocytic|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

LDB3 ITGA4 IL21R

2.11e-04193273000b9e6a819b94ea2e6e9173daf97ba9ac2b6cc6
ToppCell10x5'-bone_marrow-Lymphocytic_T_CD4/8-lo|bone_marrow / Manually curated celltypes from each tissue

ITGA4 APMAP IL21R

2.14e-04194273afbf3cecffa2c5e830ebca5db950528cc78fd269
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

HLTF ITGA4 APMAP

2.14e-0419427364535db0420e53e4d777d2333b5051e63e8a3373
ToppCell10x5'-blood-Lymphocytic_T_CD8|blood / Manually curated celltypes from each tissue

ITGA4 APMAP IL21R

2.20e-041962732bf0f36af1d0934c03999dbbff3c51ae9432386d
ToppCellsystemic_lupus_erythematosus-flare-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-female|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

ITGA4 UBE2V1 APMAP

2.24e-041972732e9677b4b9a7c88db16416e5f114a2031ec3bc24
ToppCellsystemic_lupus_erythematosus-flare-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

ITGA4 UBE2V1 APMAP

2.24e-041972734c9919914079e76b1d2220b249e0d0b0d9bf4bc0
ToppCellBronchial-NucSeq-Endothelial-Endothelia_vascular-VE_pulmonary_venous|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

PKLR DHH ABCC8

2.31e-041992733a4deea6e11a0555d27497b7c9983350797aac69
ToppCellBronchial-10x5prime-Immune_Lymphocytic-NK-ILC-T_NK-NK_CD11d|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

ITGA4 APMAP IL21R

2.31e-04199273ed460ff7fb82d3f0eed689d56f50d40514f74b48
ToppCellParenchymal-NucSeq-Immune_Lymphocytic-T-T_CD8-CD8_GZMK+|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ITGA4 APMAP IL21R

2.34e-042002737a9c3f51d4a8fda5f1b7e0be6fcf9c1c92fffe99
ToppCellBronchial-10x5prime-Immune_Lymphocytic-NK-ILC-T_NK|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

ITGA4 APMAP IL21R

2.34e-04200273b4d956067eb292cf2855c674d1eb05a5f2d988f7
ToppCellBronchial-10x5prime-Immune_Lymphocytic-NK-ILC-T_NK-NK|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

ITGA4 APMAP IL21R

2.34e-04200273d1cfc4ef6ae75c486427e393d98b84a2a7ec67fe
ToppCellTracheal-NucSeq-Immune_Lymphocytic-T-T_CD8-CD8_CTL|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ITGA4 APMAP IL21R

2.34e-04200273893bb7c25ad7c6589a4c7c0364c2ace666e9b4be
ToppCellBronchial-10x5prime-Immune_Lymphocytic-NK-ILC|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

ITGA4 APMAP IL21R

2.34e-04200273c09bb5c994f098d86e873bd3f1d911b02563e6e2
Diseasemetastasis measurement, disease progression measurement

UBE2V1 POLR2A

4.44e-0434272EFO_0007675, EFO_0008336
DiseaseInflammatory Bowel Diseases

ITGA4 HPS1

4.71e-0435272C0021390
Diseaseserum non-albumin protein measurement

TMEM131L POLR2A IL21R

4.27e-03361273EFO_0004568
Diseaseeosinophil measurement

TMEM131L APMAP

4.39e-03108272EFO_0803540

Protein segments in the cluster

PeptideGeneStartEntry
GTTRGMTPPGWLSYI

ADAM29

41

Q9UKF5
MGFYWRSSPSGPSNP

BRI3BP

201

Q8WY22
MPRRGYSKPGSWGSF

BTBD17

1

A6NE02
SSSGGYWVGMSTIRP

APMAP

311

Q9HDC9
HLSYPGEPGSMTVTW

ACP7

36

Q6ZNF0
MGTPILRDSWGGTPL

ESPNL

261

Q6ZVH7
MSYSVTLTGPGPWGF

LDB3

1

O75112
GTSYHAWVSLRPGPM

HMCN2

4826

Q8NDA2
GAGYPSLPTMTVSDW

IGBP1

256

P78318
VTGTPYWMSPEVISG

MAP3K2

521

Q9Y2U5
TGWRPGSGYTNIMRV

PKLR

556

P30613
MSLASGPGPGWLLFS

LRRC52

1

Q8N7C0
PYTMVSPSGRAGNWP

MED14

1096

O60244
PGGAVQPTGMHWYSR

DHH

371

O43323
IVMGAPGSSYWTGSL

ITGA4

211

P13612
RAGPMPGSSYQGTWS

IL21R

201

Q9HBE5
WGSGRAGPSYSMPVH

HLTF

186

Q14527
SSGSTIWLEGGTPPM

HPS1

311

Q92902
RGTPTEPMTGVYWIP

PKD1L1

1006

Q8TDX9
SLSPMSGLFGSIWAP

TMEM131L

1526

A2VDJ0
HPLPWSMRQTSSGYG

PPP1R32

101

Q7Z5V6
IMGGYFTWTPDGIPT

ABCC8

681

Q09428
PAYGAWSPSVGSGMT

POLR2A

1526

P24928
TRWTGMIIGPPRTIY

UBE2V1

46

Q13404
PSHLWGQYSGGPSMS

TET3

1431

O43151
MGGHLSPWPTYTSGQ

TSNAXIP1

1

Q2TAA8
RGYWTQLSMLIPGPG

ZMYND15

401

Q9H091
SGIPKVADPWGGSYM

MMUT

416

P22033